accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q8DAR1
GLGC1_VIBVU
ADP-glucose synthase 1
Vibrio
MAGVLGMILAGGEGSRLRPLTESRSKPAVPFGGSYRLIDFALNNFVNADLMRIYVLTQFKSQSLFHHMKKGWNINGITDRFIDPIPAQMRTGKRWYEGTADAIYQNLRFMELSEPEQVCIFGSDHIYKMDIKQMLSFHKEKLAALTVSALRMPLAEASQFGVIEVDAEGRMVGFEEKPSAPKSIPGDPDFALVSMGNYIFEADVLFAELIEDADNENSSHDFGKDIIPKMFPRGDVFVYDFSQNRISGEKAEVYWRDVGTIDAYWQAHMDLLKTDAPFSLYNRKWPLHTYQPPLPPATFTDSDNGRVQIIDSLVCNGSYVRGSRIEKSVLGFRSNIASACDISESILLGDVKVGEGCVLRRVIVDKDVDIAPGTQIGVNLQEDKKIFHVSDDGIVVIPKGARVGY
Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.
Q8DAR1
P83243
KA131_TITOB
Toxin To1
Tityus
ACGSCRKKCKGSGKCINGRCKCY
Blocks reversibly Shaker B potassium channels. Also displaces binding of noxiustoxin to mouse brain synaptosome membranes.
P83243
B0Y0Y6
CLP1_ASPFC
mRNA cleavage and polyadenylation factor clp1
Aspergillus subgen. Fumigati
MSLPGLELSQTSSEREFVPAPPTQITLSKGSEWRFEVAFGTAIRVKLLAGTAELFGTELAASQTYTFSGTKAAIYTWHGCTLEVSAGDTISTIDGLGSGGLNGEGARGYGAGGCQSEYTAEETPMVEYANVHFALEAMRQEAKATGKDGPRVLILGPENAGKTSVAKILTAYATKVGRQPIVVNLDPAEGMLSVPGTLTATAFRTMMNVEEGWGSSPMSGPSAVPVKLPLVYFYPLQNPLEAEGAVYRPIVSRLALSVTGRMAEDEDTRETGIIVDTPGILSAGKPGSLEIINHIVTEFASSERLYSTMMKNYDNKPTSSASAAASDERITVVKLSKSGGCVDRDAAFMKSVRESQIRTYFFGNPIPSTASAALSMSASSTTNITLSPHAQQLDFDSLAVYNYTIASSDEDEDEYDPSQFGASDTFLPGGRNDAEGPETKHAEETSFTSSVPGLGGPSGDDAASGSSAVPLKKVLPPAPNTLANSLLAVTHTAPNASPAEIRDASIMGFLYVADVDSEKGKIRVLAPIGGRVPPRAIVWGKKWPGEVVGLVG
Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.
B0Y0Y6
P32568
SNQ2_YEAST
Protein SNQ2
Saccharomyces
MSNIKSTQDSSHNAVARSSSASFAASEESFTGITHDKDEQSDTPADKLTKMLTGPARDTASQISATVSEMAPDVVSKVESFADALSRHTTRSGAFNMDSDSDDGFDAHAIFESFVRDADEQGIHIRKAGVTIEDVSAKGVDASALEGATFGNILCLPLTIFKGIKAKRHQKMRQIISNVNALAEAGEMILVLGRPGAGCSSFLKVTAGEIDQFAGGVSGEVAYDGIPQEEMMKRYKADVIYNGELDVHFPYLTVKQTLDFAIACKTPALRVNNVSKKEYIASRRDLYATIFGLRHTYNTKVGNDFVRGVSGGERKRVSIAEALAAKGSIYCWDNATRGLDASTALEYAKAIRIMTNLLKSTAFVTIYQASENIYETFDKVTVLYSGKQIYFGLIHEAKPYFAKMGYLCPPRQATAEFLTALTDPNGFHLIKPGYENKVPRTAEEFETYWLNSPEFAQMKKDIAAYKEKVNTEKTKEVYDESMAQEKSKYTRKKSYYTVSYWEQVKLCTQRGFQRIYGNKSYTVINVCSAIIQSFITGSLFYNTPSSTSGAFSRGGVLYFALLYYSLMGLANISFEHRPILQKHKGYSLYHPSAEAIGSTLASFPFRMIGLTCFFIILFFLSGLHRTAGSFFTIYLFLTMCSEAINGLFEMVSSVCDTLSQANSISGILMMSISMYSTYMIQLPSMHPWFKWISYVLPIRYAFESMLNAEFHGRHMDCANTLVPSGGDYDNLSDDYKVCAFVGSKPGQSYVLGDDYLKNQFQYVYKHTWRNFGILWCFLLGYVVLKVIFTEYKRPVKGGGDALIFKKGSKRFIAHADEESPDNVNDIDAKEQFSSESSGANDEVFDDLEAKGVFIWKDVCFTIPYEGGKRMLLDNVSGYCIPGTMTALMGESGAGKTTLLNTLAQRNVGIITGDMLVNGRPIDASFERRTGYVQQQDIHIAELTVRESLQFSARMRRPQHLPDSEKMDYVEKIIRVLGMEEYAEALVGEVGCGLNVEQRKKLSIGVELVAKPDLLLFLDEPTSGLDSQSSWAIIQLLRKLSKAGQSILCTIHQPSATLFEEFDRLLLLRKGGQTVYFGDIGKNSATILNYFERNGARKCDSSENPAEYILEAIGAGATASVKEDWHEKWLNSVEFEQTKEKVQDLINDLSKQETKSEVGDKPSKYATSYAYQFRYVLIRTSTSFWRSLNYIMSKMMLMLVGGLYIGFTFFNVGKSYVGLQNAMFAAFISIILSAPAMNQIQGRAIASRELFEVRESQSNMFHWSLVLITQYLSELPYHLFFSTIFFVSSYFPLRIFFEASRSAVYFLNYCIMFQLYYVGLGLMILYMSPNLPSANVILGLCLSFMLSFCGVTQPVSLMPGFWTFMWKASPYTYFVQNLVGIMLHKKPVVCKKKELNYFNPPNGSTCGEYMKPFLEKATGYIENPDATSDCAYCIYEVGDNYLTHISSKYSYLWRNFGIFWIYIFFNIIAMVCVYYLFHVRQSSFLSPVSILNKIKNIRKKKQ
Could be an ATP-dependent permease. Confers hyper-resistance to the mutagens 4-nitroquinoline-N-oxide (4-NQO) and triaziquone, as well as to the chemicals sulphomethuron methyl phenanthroline when present in multiple copies. Exhibits nucleoside triphosphatase activity.
P32568
B2A5T8
SYP_NATTJ
Prolyl-tRNA synthetase
Natranaerobius
MSKNNEEFVKEITPQSEDYSQWYLDVIKKTKLVDYAPVKGCMVIRPYGYAIWEKMKEGLDRRIKETGHENAYFPLFIPESLLQKEADHVEGFAPEVAWITKGGDEELSESLAVRPTSEAMFGEMYSDWIQSWRDLPVLINQWANVVRWEKSTKPFLRTSEFLWQEGHTAHRTEEDAEEEALQMLDVYKDFVENDMAIPVLNGLKSEKEKFAGALRTFCIEALMSDGRALQAGTSHNLGQHFAKVFDITFLDQDDERKYVWQTSWGVSTRLIGALIMVHGDNRGLKIPPKVAPHQLVMVPITPKKQREQVLEESDKLYQELKDKFRVKLDNREEHTPGWKFNEWEMKGVPIRLEIGPKDIEKDQVVLVRRDTDEKMFVKRDELIDKLEELIEDIQNKMLQTAKNFLEENTHTASSLDELGQILEQKRGMIKAYWCGNQACEEKVKDDTKATIRVIPFEAETGGSCIACGYHNDDNKEVFFARAY
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
B2A5T8
A7Z1T2
CFR_BACVZ
23S rRNA m8A2503 methyltransferase
Bacillus amyloliquefaciens group
MQQKNKYIRIQEFLKQNKFPDFRMNQIKNAVFQGRINHFNEITVLPKSLRKLLIEEFGESILNIAPLKVQHSEQVTKVLFEISGDEKIETVNMKYKAGWESFCISSQCGCHFGCKFCATGDIGLKRNLTSDEMTDQILYFHLKGHSIDSISFMGMGEALANVQVFDALHVLTNPELFALSPRRLSISTIGIIPGIKKITQDYPQVNLTFSLHSPFNEQRSKLMPINERYPLLEVMDTLDEHIRVTSRKVYIAYIMLPGVNDSIDHANEVVNLLRSRYKRGNLFHVNIIRYNPTVSSPMRFEEVNEKQVVNFYKKLKSAGINVTVRSQFGIDIDAACGQLYGNYQKNKNQ
Specifically methylates position 8 of adenine 2503 in 23S rRNA. Confers resistance to some classes of antibiotics.
A7Z1T2
A5GLI2
PDXJ_SYNPW
Pyridoxine 5'-phosphate synthase
unclassified Synechococcus
MASLGVNIDHIANVRQARRTVEPDPVPMALLAELGGADGITVHLREDRRHIQDRDVDLLRQTVRSRLNLEMAATEDMVLIALRVQPDMVTLVPERREEVTTEGGLDVSSQRVDLTSKISRLQDAGIPVSLFVDPERGQLEACRDCRARWVELHTGTYAEAKWTDQPSELARLTEATALARAMGLRVNAGHGLTYQNVEPVAAIEGMEELNIGHTIVARAVAVGLQQAVREMKALVQNPRRDPLFGSY
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
A5GLI2
Q82IV0
DEF1_STRAW
Polypeptide deformylase 1
Streptomyces
MAQQDTDQQHTGVLPVDDDGFVIDAEDCEEREAAYRERGTSRPITVVGNPVLHKECKDVTDFGAELEQLVADMFASQRTAEGVGLAANQIGVDLKVFVYDCQDDEGTRHVGVVCNPKLVDLPADRRRLDDSNEGCLSVPTAYAPLARPDYAEVTGQDEKGNPIKVRGTGYFARCLQHETDHLYGYLYIDRLSKRERKDALRQMAENEPRYPVVAND
Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
Q82IV0
B7IDI7
MURA_THEAB
UDP-N-acetylglucosamine enolpyruvyl transferase
Thermosipho
MGYFKVKNSILNGNVRISGAKNSALPILAATILSSEKLEIENVPDLLDVQTMIEILRKIGKKVIFENNKVTLNGTVENHVVPYDLVRKMRASFNVAGPLAVILGESKVSLPGGCAIGVRPVDYHIMGLKKLGFEVEIEHGEVYIKKGKKEKEVIINLPFPSVGATEHLMTTAALMEGTTVIENAAMEPEIVDLQNFLNSLGAKIQGAGSRKIVIEGVNSLNGGSYKVIPDRIEAGTYAIAIAATGGKGYIEEIIPEHLEILWEILKETGTNVIIEKNRVFVDGEGKKRGININIQPYPGFPTDLQPQILVYLSLADGVSMVVENVFKNRFHHIDELVRMGADIRVVDGTAIVNGVKKLSGTKVEGTDLRATAALIIAGLVAEGTTEVHNDFHVLRGYENIVEKIRHLNGEIEHIV
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
B7IDI7
B1XLK6
HEM1_SYNP2
Glutamyl-tRNA reductase
unclassified Synechococcus
MNIVVVGLSHKTAPVEIREKLSIQEAKMDEAIAHLKSYPHVEEVAVISTCNRLEIYAVVQETEQGVREICQFLAETGQLQLNRLRRYLFTLLHQDAIRHLLRVAAGLESLVLGEGQILAQVKAAHKLGQQHKGLGRLLDRMFKRAITAGKRVRSETNIGTGAVSISSAAVELAQMKVKDLSNQKIAIIGAGKMSRLLVQHLVSKGAEDITIVNRSERGARDLAKKFPDVDLQLELLPEMLNVVEQADIVFTSTGATEPILDRAKLENLDLHTLILIDISVPLNVAADVEEIAGVRLYNVDALKEVVAQNQASRRKMAEEAEALLEEEVENYIQWWQSLETVPTISSLRSKVESIREQELEKALSRLGAEFEEKHQEVIETLTRGIVNKILHDPMVQLRAQQDIEARRVCLQSLQMLFNLETEEAI
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
B1XLK6
P0DP67
YAFV_YEREN
Omega-amidase YafV
Yersinia
MSTLKLTLLQQPLVWLDAQANLRHFDMLLESIQQRDVIVLPEMFTTGFAMNAAENALPETEVIDWLRHWSVRTDALIGGSVALNTPDGAVNRFLLVQPDGTILRYDKRHLFRMAGEHHHYLAGKERKVVEWRGWRILPQVCYDLRFPVWSRNQQDYDLALYVANWPAARAKHWQTLLAARAIENQAYVAGCNRVGDDDNGHHYQGNSVILDALGEIQAQAEPGQAAQLDAELSLETLQAYRERFPAFHDTDKFLLL
Hydrolyzes alpha-ketoglutaramate (a-KGM) to alpha-ketoglutarate (alpha-KG) and ammonia (specific activity 21 umol/min/mg), has very weak activity on L-glutamine, and no activity on deaminated glutathione (dGSH) or glutathione. May function as a metabolite repair enzyme.
P0DP67
Q99547
MPH6_HUMAN
M-phase phosphoprotein 6
Homo
MAAERKTRLSKNLLRMKFMQRGLDSETKKQLEEEEKKIISEEHWYLDLPELKEKESFIIEEQSFLLCEDLLYGRMSFRGFNPEVEKLMLQMNAKHKAEEVEDETVELDVSDEEMARRYETLVGTIGKKFARKRDHANYEEDENGDITPIKAKKMFLKPQD
RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.
Q99547
C1DST4
LPXA_AZOVD
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase
Azotobacter
MSLIDPRAIIDPSATLAPDVRVGPWTLIGPHVHIGEGTEIGPHVIVRGPTWIGRHNRIFQFSTIGEDTPDLKYKGEPTRLVIGDHNVIREGVTIHRGTVQDRSETTIGDHNLIMAYVHIGHDSVMGSHCILVNNASLAGHVHVGDWAILSGYTLIHQHCQIGAHSFVGMGSGVSKDVPAFVTVLGSPAQARSMNFEGMRRRGFSPEAMNALRRAYKVVYRQGLTVEQALVELEESAKQFPEVAIFRDSVRASTRGITR
Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
C1DST4
B2JP67
GCH4_PARP8
GTP cyclohydrolase FolE2
Paraburkholderia
MNQMNPAFVMPDVQSTVDTRQIPIQRVGVKAVRHPLTVRTPDGSAQPTVGTWNLDVHLPAEVKGTHMSRFVALLEENKAPLDSSAFRALLTSMLEKLEAPAGRIEVSFPYFVNKTAPVSGVQSLLDYEVSLMGDSRDGATRLFLKVLVPVTSLCPCSKKISQYGAHNQRSHVTINAELIDDVPVEDLIRIAEEEASCELWGLLKRPDEKFVTERAYENPKFVEDLVRDVAQRLNDDHRIVAYVLEAENFESIHNHSAYAVIESDKRLR
Converts GTP to 7,8-dihydroneopterin triphosphate.
B2JP67
Q1BFX4
Y088_MYCSS
Putative S-adenosyl-L-methionine-dependent methyltransferase Mmcs_0088
unclassified Mycobacterium
MSSLRTADDTWDIATSVGSTAVMVAASRAAETERDEALIRDPYARLLVTGAGTGIWESVLDAKFVETVAAADAEAAAIFEHMISYQAVRTHFFDAFFTAAAEAGIRQIVILASGLDSRAYRLDWPSGTTVYEIDQPKVLEYKSATLAEHGVEPAATRREVGIDLRHDWPAALRGAGFDPSRPTAWLAEGLLMYLPADAQDRLFEQITELSAPGSRVAAETAGVQAEDRRQQMRERFERIAEKFDMTASLDIQQLIYEDPDRADVADWLDAHGWTATAVSSQQEMRRLDRWALPADLTDDDAFSNFVTAEKQS
Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity.
Q1BFX4
C5BZB0
CH60_BEUC1
Chaperonin-60
Beutenbergia
MAKIIAFEEEARRGMERGLNHLADAVKVTLGPKGRNVVLEKKWGAPTITNDGVSIAKEIELEEPFEKIGAELVKEVAKKTDDVAGDGTTTATVLAQALVREGLRNVAAGANPIALKKGIDKAVEAVTAALLEQAKEVETKEEIAATAGISAGDPAIGELIAEALDKVGKEGVITVEESNALGLELELTEGMRFDKGYLSAYFVTDQERQEAVLEDAYILLVESKISSVKDLLPLLEKVIQGGKSLVIIAEDIEGEALATLVVNKLKGTFKSVAVKAPGFGDRRKAMLQDMAILTGGQVISETVGLSLENADLDALGQARKIVVTKDETTIVEGAGDPDQLAGRVAQIRAEIENSDSDYDREKLQERLAKLAGGVAVIKAGAATEVELKERKHRIEDAVRNAKAAVEEGIVAGGGVALIQAGKVAFETLELVGDESTGGNIVKVAIDAPLKQIAINAGLEGGVVAEKVRSLPAGHGLNAATGDYEDLLAAGINDPVKVTRSALQNAASIAGLFLTTEAIVADKPEKASAPAGGGDGDMGGMGF
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
C5BZB0
B6JCP2
TRPB_AFIC5
Tryptophan synthase beta chain
Afipia
MSLPKPNSFRAGPDERGHFGTFGGRFVAETLMPLILDLEKAYAAAKADPSFQKEMNGYLKDYVGRPSPLYFAERLTEHLGGAKIYLKREELNHTGSHKVNNVLGQIMVARRMGKKRIIAETGAGQHGVATATLCARFGLECIVYMGAVDVARQEPNVIRMEMLGAKVVPVQSGTRTLKDAMNDALRDWVTNVATTFYCIGTVAGPHPYPAMVRDFQSVIGHETREQMMAAEGRLPDSLVACIGGGSNAMGLFHPFLDEPAVEIFGVEAAGHGLTNLHAASLAGGRPGVLHGNRTYLLMNEDGQIQDAHSISAGLDYPGIGPEHAWLHETGRVTYLSATDEEALAAFQLLSRLEGIIPALESAHAIAKLSQLAPKRPRDHLMVVNLSGRGDKDVPQVGDILRGRKS
The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.
B6JCP2
A8MDY8
LEUC_CALMQ
Isopropylmalate isomerase
Caldivirga
MGLTLTEKILSKAAGRQVSPGDVTEITVDLAAFHDLTGHHVVEVMENIGAVKVWDLDRFVIAFDHLAPPPNDRAAEIQVKLRKFAKSINVRNFHDVGDGILHQLLLEKYALPGQVVMAADSHTTTVGAVGAFAQGMGASDMAAILMTGKTWLMIPEPFLIRLINEPAPGVYGKDVALHILSVFKAEGLNGKSVELQVEKPKAFPMDYRATVSNMGVEFGADAAIFIPDEETVSYLSRSRGINVKPITPDPDAKYVDEYTIELNKLEPLVAAPHSVDNVKPVSEVEGIEVDYVFIGSCTNGRLSDLEAAARILKNGKVKARCIVIPASRDLFTKALDAGYVETLTKAGCVVTYGTCGPCLGGHFGVIGPGETAVSTGSRNFKGRMGSPEGKVYLANAATAAATALEGRLTDPRKYL
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
A8MDY8
Q5HNR9
DTD_STAEQ
Gly-tRNA(Ala) deacylase
Staphylococcus
MKIIVQRVKNARVTNDTIDNQINKGYCLLVGVGQNSTEEDVKVIARKIAHARLFEDENDKLNLNIQQVEGEILSVSQFTIYADVKKGNRPGFSNSKAPEQAKDLYQKFNKELEGYGLIVKTGEFGTHMNVEINNDGPVTLIYESQDGKII
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.
Q5HNR9
Q5XDY5
NANE_STRP6
ManNAc-6-P epimerase
Streptococcus
MPDKPTKEKLMEQLKGGIIVSCQALPGEPLYSETGGIMPLMAKAAQEAGAVGIRANSVRDIKEIQAITDLPIIGIIKKDYPPQEPFITATMTEVDQLAALNIAVIAMDCTKRDRHDGLDIASFIRQVKEKYPNQLLMADISTFDEGLVAHQAGIDFVGTTLSGYTPYSRQEAGPDVALIEALCKAGIAVIAEGKIHSPEEAKKINDLGVAGIVVGGAITRPKEIAGRFIEALKS
Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P).
Q5XDY5
Q2RNK3
COQ7_RHORT
2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase
Rhodospirillum
MTSPSSRTPRGSTPPFEPSADELVLHASGRKTAEDRLPGDPSPAALIDRFLRVDQAGEHGAVRIYQGQLAVLGRRSANVGVLRHMLAQEEVHLATFDKLVADRRARPTLLGPLWHVAGFALGAGTALLGEKAAMACTTAIEEAIDGHYKDQYDRLGDDELPLKATIDTFRREELEHRDIGYANGARQAPAFPVLSGAIKAGAKLAIWVSERV
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
Q2RNK3
Q49434
T1SX_MYCGE
Putative type-1 restriction enzyme specificity subunit MG438
Mycoplasma
MTPKLKLNNNINWTKRTIDSLFDLKKGEMLEKELITPEGKYEYFNGGVKNSGRTDKFNTFKNTISVIVGGSCGYVRLADKNFFCGQSNCTLNLLDPLELDLKFAYYALKSQQERIEALAFGTTIQNIRISDLKELEIPFTSNKNEQHAIANTLSVFDERLENLASLIEINRKLRDEYAHKLFSLDEAFLSHWKLEALQSQMHEITLGEIFNFKSGKYLKSEERLEEGKFPYYGAGIDNTGFVAEPNTEKDTISIISNGYSLGNIRYHEIPWFNGTGSIALEPMNNEIYVPFFYCALKYLQKDIKERMKSDDSPFLSLKLAGEIKVPYVKSFQLQRKAGKIVFLLDQKLDQYKKELSSLTVIRDTLLKKLFPDMTERTKSIKDY
The specificity (S) subunit of a type I restriction enzyme; this subunit dictates DNA sequence specificity. This bacterium does not encode the associated endonuclease or methylase subunits.
Q49434
Q9W415
WUHO_DROME
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho
Sophophora
MCTTISFAEPEIVLGHGRRVLFVNPDDLQIFKEIELPPDLGLKGHTSQSQESCTAAAAASTATAASGQAPGGKEQQLANQPEEGGTSASASGLGCATSTSVQNVAYSPDGQLLAVTTSGKQKALLLYRSRPENARLLSARPLARASSALRFCSDSSSILVTDKTGDCYQYDCVEVEAPPRLLLGHLSVVYDILWSEDQQHIITCDRDDKIRVTNYPATFDIHSYCLGHREFVSGLALLTEQHIASASGDKTLRVWNYIQGKELLQHELPAPAVRLLVRQLEPEKVFQAAVLFYEHVDALGLYRLERSSDDTWSVTATQLVCAEAGSWSISNFTLTSDRIYITGAENERLSLRVYDIATGQPASSGVPEGWLKMVLDGLGANEEGAPPFIPEDLSVWFKKRFDNVSDYLERKKRRIEEQQQQKCG
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. Required during gametogenesis.
Q9W415
C0ZG86
SYI_BREBN
Isoleucyl-tRNA synthetase
Brevibacillus
MDYSKTLALPKTEFPMRGNLPSREPQMQAVWEEQNIYQQVLDRTKDRPSFVLHDGPPYANGDIHIGHALNKILKDFIVRYKSMAGFYAPYIPGWDTHGLPIEQAIINAQGLDRRSIEVNDFRQRCEEYAWSYIDKQRDQFKRLGVRGDWENPYVTLLPEYEANQIRVFGEMAKKGYIYKGLRCVYWSPSSETALADAEIEYKDKRSPSIYVSFQVADGKGKLDIETGVVIWTTTPWTLPANLAISLHPELEYNVVKVDGRKFLVANGLIEAASKEIGWEGVEILATFKGQELEGVETQHPFYDRKSPLILGEHVTLDAGTGCVHTAPGHGEDDFNVGQKYNLGVLCPVDHEGKMTNEAPGFEGLFYEDANKVITEKLKENGALLKLSFFTHSYPHDWRTKKPVIYRATEQWFASIDGFRTQMLEAIKNVKWIPHWGETRLANMIADRGDWCISRQRVWGVPIPIFYCKACNEPIINDTTINHVADLFRKEGSKVWFSREANELVPEGLSCTKCDCNDFRKETDIMDVWFDSGSSHQAVLRERGIAWPADMYLEGSDQYRGWFNSSLSTGVAVYGTAPYKSVLSHGFALDGEGRKMSKSLGNVIVPQQVIDKMGADILRLWVASVDYQADVRISDAILNQIAEVYRKIRNTFRFLLGNLDGFNPATDRVAYEELGELDRYVLAKAAKVAKRTRKAYDEYQFHTVFHAVHNFCVIDLSAFYLDICKDRLYVEAPDSLKRRAAQTVMYDCLLSLVKLVAPLLPHTADEVWAFIPGVEEKSVQLTDMPEGDEQHLSFAAEAESKWDAFLAIRDEVLKAMEEARRNKVFGNSVDAKLALYPQTEEVAKTLAAMDDLADLFIVAHVDVHSGSAPAEAVQLEGIAAVVSAADGGKCERCRVVKPDVGTRESHASLCVRCADVVEQHYAHVTE
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
C0ZG86
P40841
BR2EE_PELLE
Brevinin-2Ee
Pelophylax
GIFDKLKNFAKGVAQSLLNKASCKLSGQC
Shows antibacterial activity against representative Gram-negative and Gram-positive bacterial species, and hemolytic activity.
P40841
A6VI43
COFH_METM7
FO synthase subunit 2
Methanococcus
MDFISFKEKEISKKECLELFENTENFFDVIKLADSLRKDIVGDAVTYVVNANINFTNICTGTCGFCAYKAEHGDPHAFFLNPDEVAKKALEARKIGATEVCIQGGLLKEIDTYFQAEILKKVKEITAPYGKIDVHAFSPMEVKSAAENAGLNVKEALKILKESGLNSMPGTAAEILNDEIRSEICPTKLKTSEWIDVVSNAHKTGIKTTCTMMYGHVEENDHLAEHLSILRNIQKETGGFTEFVPLTFLHENAPLYHTERVKSGASGMLDLKVYAISRIFFKDSIKNIQTSWVKLGTKLSQVSLNCGANDIGGTLMEENISKSAGGSYGTYMSEEQLKDMVLAVGRIPKQRNTAYEIIE
Catalyzes the radical-mediated synthesis of 5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D-ribitylamino)uracil and L-tyrosine.
A6VI43
A9VRF1
PURL_BACMK
Phosphoribosylformylglycinamidine synthase subunit II
Bacillus cereus group
MSLMLEPNPTQIKEERIYAEMGLTDEEFAMVEKILGRLPNYTETGLFSVMWSEHCSYKNSKPVLRKFPTTGERVLQGPGEGAGIVDIGDNQAVVFKMESHNHPSAIEPYQGAATGVGGIIRDVFSMGARPVALLNSLRFGELQSPRVKYLFEEVVAGIAGYGNCIGIPTVGGEVQFDPCYEGNPLVNAMCVGLINHEDIKKGQAHGAGNTVMYVGASTGRDGIHGATFASEELSESSEAKRPAVQVGDPFMEKLLIEACLELIQSDALVGIQDMGAAGLTSSSAEMASKAGMGIEMYLDDVPQRETGMTPYEMMLSESQERMLIVVKKGREQEIVDLFEKYGLAAVTMGKVTEDKMLRLFHKDEMVAEVPADALAEEAPIYHKPSKEAAYFAEFQQMKMETPKVEDYKETLLALLQQPTIASKEWVYDQYDYQVRTSTIVTPGSDAAVIRVRGTEKGLAMTTDCNSRYIYLDPEVGGKIAVAEAARNIVCSGGEPLAITDCLNFGNPEKPEIFWQIEKSVDGMSEACRKLQTPVIGGNVSMYNERSGEAVYPTPTVGMVGLVHDLKHVTTQEFKQAGDLVYVIGETKAEFGGSELQKMIYGKIFGQSPSIDLDVELKRQKQVLAAIQAGLVQSAHDVAEGGLAVAITESAIGAKGLGATVKLDGEATAVLFAESQSRFVITVKRENKEAFEKAVEAIQVGEVTNTNEVTIHNEENEVLLTANVDEMRKAWKGAIPCLLK
Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.
A9VRF1
Q9ZRW8
GSTUJ_ARATH
Glutathione S-transferase 8
Arabidopsis
MANEVILLDFWPSMFGMRTRIALREKGVEFEYREEDLRNKSPLLLQMNPIHKKIPVLIHNGKPVNESIIQVQYIDEVWSHKNPILPSDPYLRAQARFWADFIDKKLYDAQRKVWATKGEEQEAGKKDFIEILKTLESELGDKPYFSGDDFGYVDIALIGFYTWFPAYEKFANFSIESEVPKLIAWVKKCLQRESVAKSLPDPEKVTEFVSELRKKFVPE
Catalyzes the glutathionylation of 12-oxophytodienoate (OPDA). In vitro, possesses glutathione S-transferase activity toward 1-chloro-2,4-dinitrobenzene (CDNB) and benzyl isothiocyanate (BITC), and glutathione peroxidase activity toward cumene hydroperoxide.
Q9ZRW8
B2K5J4
SUFS_YERPB
Selenocysteine reductase
Yersinia
MNFPIERVRADFPLLSRQVNGQPLVYLDSAASAQKPQAVIDKELHFYRDGYAAVHRGIHSLSAEATQQMEAVRTQVADFIHAASAEEIIFVRGTTEAINLVANSYGRHFLAAGDSIIITEMEHHANIVPWQMLAQDLGVEIRVWPLTATGELKITALAALIDDTTRLLAVTQVSNVLGTVNPIKDIVAQAKAAGLVVLVDGAQAVMHQPVDVQALGCDFYVFSGHKLYGPSGIGILYGKSALLQQMPPWEGGGAMIKTVSLTQGTTFADAPWRFEAGSPNTAGIMGLGAAIDYVTELGLLPIQQYEQSLMHYALAQLSQIKSLTLYGPTERAGVIAFNLGQHHAYDVGSFLDQYGIAIRTGHHCAMPLMAFYQVPSMCRASLALYNTREDVDRLVAGLQRIEKLLG
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo.
B2K5J4
B8IH88
NDK_METNO
Nucleoside-2-P kinase
Methylobacterium
MAIERTFSILKPDATARNLTGAINAVIEEAGLRIVAQRRIRMSEAQAKTFYEVHAERPFYGELVSFMTSGPVVVQVLEGENAVAKYREVMGATNPAQAAEGTIRKKFALSVGENSVHGSDSAENAKVEIAQFFDEKDIVG
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
B8IH88
C5B9W5
DADA_EDWI9
D-amino acid dehydrogenase
Edwardsiella
MRVVILGSGVIGVTSAWYLAQAGHQVTVVDRQEGPGLETSAANAGQISPGYAAPWAAPGIPLKALKWLFQRHAPLAMSLDGSLFQLRWLWQMLRNCDSTHYAQNKARMVRLAEYSRDCLAQLRRTTTIDYEGRQLGTLQLFRTPQQYENAARDIAVLREAGVPYRLLPTAQLSTVEPALAVAGVRLSGGLHLPHDETGDCQLFTRHLAQQAAQSGVHFIFSTQVLRLLRSGARIQGVQCGHDTLVADAYVVALGAYSTGLLQDIVAIPVYPLKGYSLTLPIDDPDAAPRSTVLDESYKVAITRFDRRIRVGGMAEVVGFDMSLPLARRRTLERVVRDLYPRGGLLPQASFWSGLRPATPDGTPLVGATPLENLYLNTGHGTLGWTMACGSGQLLADIISGVTPTIRVDDLSVSRYTA
Oxidative deamination of D-amino acids.
C5B9W5
Q54C16
SGMB_DICDI
Acid sphingomyelinase B
Dictyostelium
MKVKAPILLLFVFLINFCFSIKQTQQQNFDITIDNNNYNNNNNNNKNEIINNNNKNNNNLNDEYFEKLGYDTNGTKCDICKFGINQVQKMIASKQGIEDISKYAIDLCTYLHIEKAEVCNGLIPLFANMTYNVLSYPTVTGEYVCGFVGFCPYVPRNSSNIINFPKPKPPHVPPVAPSPNSPTMKILHISDIHVDPVYESGMNADCGEPLCCRAPNGPGVGEKAAGEWGHYLCDINMKMVESMFEFIDQEFGEDIDIVFWTGDNPPHDIWEQTYDSQINASQLVTNLVKKYFGSTAKVFPAIGNHESLPVNSFPLPPGSSWIFNALSYDWSDWVNVDEQVANLQYGGYYTLPVQSGLRVISLNMNWCNNGNLYLAENSTDPANMLQWIVDTLQASEDIGEKVYLVGHIPPGIPDCIDSWSEQLLQIVNRYEDTILASFYGHTHRDEFSVYYTQSDENDPSSPMRASNVIYTTPSVTTYQHQNPSFRIFTVDSNTGYLMESSTYHTDLSQANLNGKPTWLLEYNTTNTYNIPNLTPISMDLAIQNINSSNSMLEDYHVHYYSASPYPESKPCTSISCKLDYICKMKSAAYLKYYECIHHEVNNYLLNESDDDSIKSHKKLNILLDLNNYLNNEVLKSC
Converts sphingomyelin to ceramide.
Q54C16
Q64NW2
CLPP_BACFR
Endopeptidase Clp
Bacteroides
MDDFRKYATKHLGMNAMVLDDVIKSQAGYLNPYILEERQLNVTQLDVFSRLMMDRIIFLGTQIDDYTANTLQAQLLYLDSVDPGKDISIYINSPGGSVYAGLGIYDTMQFISSDVATICTGMAASMASVLLVAGAKGKRSALPHSRVMIHQPMGGAQGQASDIEITAREIQKLKKELYTIIADHSGTSFDKVWADSDRDYWMTAQEAKEYGMIDEVLIKK
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Q64NW2
Q67P86
IF2_SYMTH
Translation initiation factor IF-2
Symbiobacterium
MEPRLRVFELARELGVDSKRVLEVLQSLNVDVKNHMSTIDQKTAEKVTDAVRRTEAQEGQGAGKSAAKSAKPAAQPKPTREANPAKTSLLEDFFGSGTRPQRPLSEKRERRPLTERRPLAERRPLAERPLVDRPVTERPLAERPAAELRPGAAKAAAPARPAAEAQPVAERRAPAEAAQAAQAERRPAEKAQPAAAAKAAPPEKAGAAPVPGAVAEQKQAATPAAAEQKPAGKAEQTAGAAQAKPARAEAGTGASSRPASAAPAAQGEKRPAAAAERREEPQAEAPQTSGPSRPVPAGPGQPARPAGSGIGVPVKPAAGGKSGLGLPTRPGEKAADGARGGGSGIGLPVKPAAGQGTAARAGGLGLPQKPKAGAPRPGGGLGAPQRPGRRGAPLAIPKLDPKVAEQAKAGEGKPRYGQSGDKRRADLYDRREHPSSQPSEEKLFGQRPKRKASAQERRVLKPITVTGPMSVKDLAHEMGVTAAEVIKTLLTGFGIMATINQELDVDTCVLVASEFGVEATVEQKEDIIEVYDRVEDPDEPAELKKPRHPVVTIMGHVDHGKTSLLDAIRQAKVAAGEAGGITQHIGAYEVELNGRKITFLDTPGHEAFTAMRARGANVTDIAVLVVAADDSVMPQTVESINHAKAANVPILVAINKIDKPEANPQRVMQDLTQYGLVPEEWGGDTIMVPVSAKQKTNLDLLLENILVLAEVSDLKANPDKPAAGTILEAALDKARGPVATVLVQAGTLNTGDVFVAGTSWGRVRAMFDHRGRKLKSAGPSTPVRVLGFDSVPQAGDVFRVTPDEKTARAIAEKRIAKAQAERLAQKAISLDDFMNQVAQGEIKDLNVIVKADVQGSVEAIRGQLEKLRNEEVKVKVIHAGVGAISESDVMLAVASKAIIIGFNVRPDDRASRAADEHGIDVRTYSVIYDIVDDIEAAMKGMLKPKIEEVILGKAEVRETFKVPKVGMAAGCMVIQGKVTRNARYRLIRDGVVVWDGEINALRRFKDEVREVSEGYECGITLQNFHDFKRGDILEAYELQEIKAG
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Q67P86
Q11UP4
MNMA_CYTH3
tRNA-specific 2-thiouridylase MnmA
Cytophaga
MSKKGRVLVAMSGGIDSSVAAVMLHEQGYEVIGMTMKTWDYANLGGSKKETGCCSLDSINDARNIAVSLGFPHYIVDIREEFGDYVINHFNKEYLDGRTPNPCVLCNTHIKWDSLLRRADKMDCDFIATGHYAQVRSENNRFVISKGLDENKDQSYALWGISQQSLSRTMFPLGHLHKTDIRAMAAERGFMDLVNKSESYEICFVPDNDYRGFLKRRNPGLEEEVRGGEFVMEDGTVVGKHEGYPFYTIGQRKGLGITLGYPVFVTEIQKENNRVVLGREEGLNRNGMWVDQLIMSKYENLKGIQKQSITKVRYNDDGTSSTIEQVGDEMRVLFHEHVKAIAPGQAAVFYEGNDVIGGGWIKSSFKQD
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Q11UP4
Q3E7X8
YE077_YEAST
Y' element ATP-dependent helicase YEL077C
Saccharomyces
MTLGNSYDAFNHDPWMDVVGFEDPNQVTNRDISRIVLYSYMFLNTAKGCLVEYATFRQYMRELPKNAPQKLNFREMRQGLIALGRHCVGSRFETDLYESATSELMANHSVQTGRNIYGVDSFSLTSVSGTTATLLQERASERWIQWLGLESDYHCSFSSTRNAEDVVAGEAASSDHHQKISRVTRKRPREPKSTNDILVAGQKLFGSSFEFRDLHQLRLCYEIYMADTPSVAVQAPPGYGKTELFHLPLIALASKGDVKYVSFLFVPYTVLLANCMIRLGRCGCLNVAPVRNFIEEGYDGVTDLYVGIYDDLASTNFTDRIAAWENIVECTFRTNNVKLGYLIVDEFHNFETEVYRQSQFGGITNLDFDAFEKAIFLSGTAPEAVADAALQRIGLTGLAKKSMDINELKRSEDLSRGLSSYPTRMFNLIKEKSEVPLGHVHKIRKKVESQPEEALKLLLALFESEPESKAIVVASTTNEVEELACSWRKYFRVVWIHGKLDAAEKVSRTKEFVTDGNMRVLIGTKLVTEGIDIKQLMMVIMLDNRLNIIELIQGVGRLRDGGLCYLLSRKNSWAARNRKGELPPIKEGCITEQVREFYGLESKKGKKGQHVGCCGSRTDLSADTVELIERMDRLAEKQATASMSIVALPSNFQESNSSDRYRKYCSSDEDSNTCIHGSANASTNASTNAITTASTNVRTNATTNASTNATTNASTNATTNSSTNATTTASTNVRTSATTTASINVRTSATTTESTNSSTNATTTASINVRTSATTTKSINSSTNATITESTNSNTNATTTESTNSKTSATTTASTNSNTSATTTESTNSKTSATTTASTNSNTSATTTESTNSNTSATTTASTNSSTNATTTESTNASAKEDANKDGNAEDNRFHPVTDINKESYKRKGSQMVLLERKKLKAQFPNTSENMNVLQFLGFRSDEIKHLFLYGIDIYFCPEGVFTQYGLCKGCQKMFELCVCWAGQKVSYRRMAWEALAVERMLRNDEEYKEYLEDIEPYHGDPVGYLKYFSVKRREIYSQIQRNYAWYLAITRRRETISVLDSTRGKQGSQVFRMSGRQIKELYYKVWSNLRESKTEVLQYFLNWDEKKCQEEWEAKDDTVFVEALEKVGVFQRLRSMTSAGLQGPQYVKLQFSRHHRQLRSRYELSLGMHLRDQIALGVTPSKVPHWTAFLSMLIGLFYNKTFRQKLEYLLEQISEVWLLPHWLDLANVEVLAADNTKVPLYMLMVAVHKELDSDDVPDGRFDIILLCRDSSREVGE
Catalyzes DNA unwinding and is involved in telomerase-independent telomere maintenance.
Q3E7X8
O05073
VPI_HAEIN
Mu-like prophage FluMu I protein
Haemophilus
MKAEKTSLAVLTAQLTSPDGWQQLLPKGEFRSRDGSPTDVAHWFIDGTIAQNLIHKARQLNQDLLVDYDHETILKAKKGIDAGNVVAAGWFNADEIQWFDDETRQGLYIKPRWTPKAYQQIKDGEFAFLSAVFPYDENGTPLELRMAALTNDPGITGMQRLAVLSATLNPQENVKMPESLRKLLAKLGVEIAEGVELTEEQANTALNALETLQTDKTKADEQVATLSAKNTEVDLSQYVPKATYDAVMSQVAVLSAKTDDVEIDNHISKARNEGRAVEAEVEYLKQFGKQQGVAALSAMLEKRPQIAVLSAQQTQTTKVEKPVEKGTAVLSAADKEAAKLLGISEQDYAKELEAK
Potential protease involved in virion morphogenesis.
O05073
Q6KIL4
KTHY_MYCMO
dTMP kinase
Mesomycoplasma
MFISFEGIDGAGKSTIIKKLKRKLPKLYPDKKFVFTREPGGKKLKEAEKIRKILLDKKTNIDPMTETLLYAASRRVHLDSLIWPALKKGHIVISDRYVDSSYVYQGIARGLGVKVVKEINDIATSNFMPDYTFFLSISEEESIIRRHKRGKPDRLEMSSKDFFSRAYEGYFKIINSPTMADRFILVNAEENVGTILKNILNEFDKILKK
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
Q6KIL4
B4F0S0
SELA_PROMH
Selenocysteinyl-tRNA(Sec) synthase
Proteus
MTHDTRSLYSQLSSIDSLLHQADIQTLVDGYGQTFIVEHLRKLQEEARIIIRQNNQLPQWHDNWAEELKNRIALQRKAAIKPVFNLTGTVLHTNLGRALMAESAIEAVSQVMRSPATLEYSLDGASRGHRDRAIADLLCELTGAEDACIVNNNAAAVLLMLATVAPDKEVVVSRGELVEIGGAFRIPDVMCQAGCRLKEVGTTNRTHLKDYRNAINENTGLLMKVHTSNYSIQGFTAEVEGTQLAALGKEMNLPTAIDLGSGSMTNLAALGLPSEPMPQDYLQQGIDLVTFSGDKLLGGPQAGIILGKKAWIEAIQHHPLKRALRVDKMTLAALDATLRLYQQPEKMIKDIPTLRLLTRTQTEIHDMAQRLLPHFQAYYGDNYHITISSCASQIGSGSLPIESLPSAALTFAAKDGKGSQLDALAAHWRNLEKPIIGRITDGRLWLDLRCLEDENALIQALSL
Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.
B4F0S0
P68573
DBH2_BACSU
SPbeta prophage-derived DNA-binding protein HU 2
Bacillus
MNKTELIAKVAEKQGVSKKEGAPSVEKVFDTISEALKSGEKVSIPGFGTFEVRERAARKGRNPQTGEEIDIPATKAPAFKPAKALKDAVKAK
Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
P68573
Q54EV7
XPO1_DICDI
Exportin-1
Dictyostelium
MENILNFNEPLDINLLDQIVSVLYNPLSNKNDIKAAQMVLGKFQEHPDAWSKVDTILETSKIVQTKFIALVIMDSLIKYRWKSLPREQCEGIKNYIVSLIIRLSSDPQTSSREKLLVNKLNLVFVQILKQEWTTNWSTFIPEIISSSKTNESLCENNMVILRLLSEEIFNFSEEQMTQTKIQTLKITFEKEFSLINDLCFYILENATRASLIKATLETLQRFLNWVPLHYIIEVNGGIAEPSKLVKLLLHKYFPEPLFRNSTLKCLTEIGNLNLGNQQYDAVFIAIIDKFMNQIKFIKPDPSKIPQDYEDGDQGERSFIHTVSLFLTGFFKSHLKIMENSLNIPYLTLAHEILVNISNIDELELFKICLEYWNFLSSNLYSDIATFTTTLLSTPPRLQLYKSVLSKVRVVLIDHMAKPEEVIVVEDENGNIVRETTKDTDSLTLYESMRETLIFLTHLDSENTQHIMLEKLQTLISGREFTFQRLNTLCWAIGSISGAQNKEQEKRFLVTVIKDLLELCQNKKGKDNKAVIASDIMYIVGQYPRFLKDHWKFLKTVVNKLFEFMHESHPGVQDMACDTFLKISKQCKRKFVVLQVEESQPFINELLNQLSTTIAHLEQSQIHTFYEAVGYMIASSSDAAFREKLVNKFMELPNHSWLQIMGAASVKVESLLTVEVARDILNLIKTNNRAAMSLENCYITQISKIYLDLLNVYRTYSDHISRNPNIYRETLGQAMRSVKKETLKLLETFIEKSSDKQVIYSNFLQPLLEAVLGDYRTNIPETRDPEVLSLMTAIITSLKQLVHPEVPKILEAVFETTLSMITKNFEDYPYHRINFFNLIRAINSNAFTVFHNLHPQQFKLLIDCVVWAFKHTERNISETGLHILKELIENVSKNSDVANVFFKTYLVSLLNDILYILTDSFHKSGFALECDILRMMFQVVENGVVKIPLFDPQQANFPSNSEYVKEIVVTFLSASPNVSRPQIQAFVTRLFNLANINNNDFKSATRDFLITLKEWKSHENADLYSDEKNIEKALALKKQSMIPGMVRPNDVNLEMNDL
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES).
Q54EV7
A3QFJ6
ZIPA_SHELP
Cell division protein ZipA
Shewanella
MENLQLVLFVLGAVAIIAVLVHGFWSIRRQQPKSLKESPMTGLYTDKTRDSDGFDADGVGPVRVVKNNAEQGIPKATSTSRATPFGARAQESEPADVSPSFSLSDEPKQKAPRSRQEPVMSATPNEEVSDAHLEQMELGLGQAPAQPSLFEDPVTERKQEAVRPAPRVEAPQSVAPASVEPVSVEPEPAPKVAEETPLGDPQDVLVLHVVAKEGEALNGAELLPSLLTLNFKFGDMDIFHRHEDNAGTGKVLFSLANMVKPGVFNPDEMEQFTTQGIVLFMTLPCYGDPLMNFSIMLNSAHQLADDLGGEVLDGGRGAWSEQTKQSYLQRIRAQM
Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
A3QFJ6
Q88UX0
RS4_LACPL
30S ribosomal protein S4
Lactiplantibacillus
MSRYTGPSWKISRRLGMSLSGTGKELARRPYAPGDHGQGRRGKLSEYGTQLREKQKLRMMYGLTERQFANLFIKAGKIREGKHGVNFMILLERRLDNMVYRLGLATTRRQARQLVNHGHITVDGKRVDIPSYEVSVGQVVSVREKSKKLAVITGAVEAVVARPNFVQFDADKLEGSLTRLPEREELEADIDESLIVEYYNKL
With S5 and S12 plays an important role in translational accuracy.
Q88UX0
A7IFX6
RS12_XANP2
30S ribosomal protein S12
Xanthobacter
MPTINQLIRKPREAQKARDKAPALQASPQKRGVCTRVYTTTPKKPNSALRKVAKVRLTNSYEVIGYIPGEGHNLQEHSVVMIRGGRVKDLPGVRYHILRGVLDTQGVKNRKQRRSKYGAKRPK
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.
A7IFX6
Q753F5
ENOPH_ASHGO
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
Eremothecium
MEEDYGVFILDVEGTVCPIAFVREQLFPYFLDKVEELINNADETERDLLADMQSRHGGAAAASLLRQLVAEDVKDPALKALQGRVWERGYASGEITAPVYADAVRFIQRNAGRVYIYSSGSVQAQRLLFGHVSNPSGDGVLDLTGHLAGFFDIPAAGRKTEAKSYERILAAIGLERQPGAAIFVSDSVAELDAASASGLSVRLAVRPGNERVSGARYTTLTDFEGL
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Q753F5
Q6PCG6
VEZA_XENLA
Vezatin
Xenopus
MTAEFDEEVVFENSPLFQYLQDLGHTDFEICPLSKEEERLAENGQGKQDVHTTEKKSIISRTVEFLKSWSPFLSKKKKDEKIHLLEIGFRLESLRTILQQEVLIQEDVELIELLDPGILSAGQTQNQQNDHLPTLWSIATPNIWETSILFVFLSAVAAFQSWSISSSLIWGPSLILFAAFTVLKTLHTWRSARLRIILRKYCTQVEGTVSNSRAFTNLVRKALRLIQETEVISRGFTLVSAACPYGKAGQHASQHLLGLRKAVYRTVRTNFRISRLATLYMLKHYPLNSEIDNVTNYICVVPLKDLGLGLCEEHVSEEDAHNLTDAFSLPALKVLFQLWIGQSSEFFRRLALLLSPENASQGPSTSPEQLPHFIWSDVVQDLPHTQAACMAELKRSYEFYRYFETQHQSGLERTAKRKEVGELNNLHGAVRSLQLHLKALLNEVIVLEDELDKLSSCKEMQAVTPEASLMLEEKLRIIQPHVQASNTCWEEALCQVERMVRKPTTKKDTGKYSCENLNYPVVSNVPPAMRIEDRDPVPEEQILEAYVEEAVTDQEFNSEEIYLFSPEERERQKREREESRRVLQELKAVLGLKASEAERQKWKQLLFSEHAVITPLLPEEPVGHFEPLLSIYPEEPHKNLGFYGEIPSEINGTEHVKDAPIQVDHGNMNHEDEAKICPVSEEVEPASCKEEEDETPCPAPRTVLPPAIKERLARIHQSSDLNFTSGLATQVAARSLTFTFLQEQTFGDEWDDDDDNEDHDHDKERNNDSSQLEG
Plays a pivotal role in the establishment of adherens junctions and their maintenance in adult life.
Q6PCG6
Q87WQ5
IF2_PSESM
Translation initiation factor IF-2
Pseudomonas
MTQVTVKELAKVVDTPVERLLQQMREAGLPHTAAEQVVTDNEKQALLTHLKSGHKAKVEEPRKITLQRKTTSTLRVAGSKSISVEVRKKKVFVQRSPEEIEAERKREMDERRAVENAARQKAEEEAKRRAEEDARNQPAAGQPASAPAQPVAAAEPVREAPAAAAPAPASAAPSADARKRDEQRRPDKPRADDRNARGGDGDRKNAPHRASVKEKAPAPRVAPRTTDEESDSFRRGGRGKGKLKKRNAHGFQSPTGPVIRDVAIGETITVGELSAQMSVKAAEVIKFMFKMGTPVTINQVLDQETAQLIAEELGHKVTLVSDNALEDSLAESLKFEGESFSRAPVVTVMGHVDHGKTSLLDYIRRAKVAAGEAGGITQHIGAYHVETERGMVTFLDTPGHAAFTAMRARGAKATDIVILVVAADDGVMPQTIEAVQHAVAAGVPLVVAVNKIDKPGADLDRIRSELSVHGVTSEEWGGDTPFVSVSAKMGTGVDELLEAVLLQAEVLELKATPSAPGRGVVVESRLDKGRGPVATVLVQDGTLRQGDMVLVGSNFGRIRAMLDENGKPVKEAGPSIPVEILGLDGTPDAGDEMSVLSDEKKAREVALFRQGKFREVKLARAHAGKLENIFENMGQAEKKTLNIVLKSDVRGSLEALNGALNGLGNDEVQVRVVGGGVGGITESDANLALASNAVLFGFNVRADAGARKIVEQEGLDMRYYNVIYDIIEDVKKALTGMLGSDVRENILGIAEVRDVFRSPKFGAIAGCMVLEGTVYRNRPIRVLREDIVIFEGELESLRRFKDDAADVRAGMECGIGVKSYNDVKVGDKIEVFEKVQVARSL
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Q87WQ5
Q5SJ65
UDGB_THET8
Uracil/hypoxanthine/xanthine DNA glycosylase
Thermus
MDREAFVQTLTACRLCPRLVAWREEVVGRKRAFRGEPYWARPVPGFGDPEARILLFGLAPGAHGSNRTGRPFTGDASGAFLYPLLHEAGLSSKPESLPGDDLRLYGVYLTAAVRCAPPKNKPTPEELRACARWTEVELGLLPEVRVYVALGRIALEALLAHFGLRKSAHPFRHGAHYPLPGGRHLLASYHVSRQNTQTGRLTREMFLEVLMEAKRLAGL
DNA glycosylase with broad substrate specificity. Can remove uracil from double-stranded DNA containing either a U/G, U/A, U/C or U/T base pair . Can also excise hypoxanthine from double-stranded DNA containing G/I, T/I, and A/I base pairs, xanthine from both double-stranded and single stranded DNA, thymine from G/T mismatched DNA, 5'-hydroxymethyluracil and 5'-fluorouracil .
Q5SJ65
Q1CV79
GLMM_HELPH
Phosphoglucosamine mutase
Helicobacter
MKIFGTDGVRGKAGVKLTPMFVMRLGIAAGLYFKKHSQTNKILIGKDTRKSGYMVENALVSALTSIGYNVIQIGPMPTPAIAFLTEDMRCDAGIMISASHNPFEDNGIKFFNSYGYKLKEEEEKAIEEIFHDEGLLHSSYKVGESVGSAKRIDDVIGRYIVHLKHSFPKHLNLQSLRIVLDTANGAAYKVAPVVFSELGADVLVINDEPNGCNINEQCGALHPNQLSQEVKKYRADLGFAFDGDADRLVVVDNLGNIVHGDKLLGVLGVYQKSKNALSSQAIVATNMSNLALKEYLKSQDLELKHCAIGDKFVSECMRLNKANFGGEQSGHIIFSDYAKTGDGLVCALQVSALVLESKQVSSVALNPFELYPQNLVNLNVQKKPPLESLKGYSALLKELDQLEIRHLIRYSGTENKLRILLEAKDEKLLESKMQELKEFFEGHLC
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
Q1CV79
A9WNI9
NB_RENSM
Ferric nitrobindin
Renibacterium
MPVEIPRDLTPELVPLSWLLGQWEGQGRLGTGEAESEHFFQRVTFSSNGLPYLEYVAESWLTDEEGMKLRPLSVEMGFWALDRKLGEADGGPGLIPADIVPALTTADDVEKLRNDTSGFDITATIVHPGGISELYYGTIKGPQIELSTDAVMRGAGAKDYSAATRIFGLVNGDLFWRWDVAAEGNSLEAHASAILKKTAAPESAEQRPSE
Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.
A9WNI9
B9JTR0
LDH_AGRVS
L-lactate dehydrogenase
Agrobacterium
MKVGIVGAGMVGSASAYALTMLGIASEIVLVDYNTDLAQAQAEDISHAVPFVSATLVRAGDYGDFAGAGVVIISAGVSQKRGETRLELLGRNAEVFRQVVDQVLAAAPNAILLIASNPVDIMTDIATRLSGLAPQRVIGSGTILDTARFRSLLGRYLEISPQSVHAYVLGEHGDSEVLAWSNAMVGAVPLMSFAKQAGKPVTDTVRSEIDAGVRHAADKIIKGKGATYYGIGAGLARIVKAIASDQRDVLSVSSVTAELAGVTNVAASVPRVIGSSGILMDLVPDLDETERIALAKSARMLKDLALSVPC
Catalyzes the conversion of lactate to pyruvate.
B9JTR0
Q703W7
GLCDH_THETK
Glucose 1-dehydrogenase
Thermoproteus
MRAVTVTPGVPESLRLREVPEPKPGPGQVLLKPLLVGVCGTDKEIIEGRYGKAPEGSDYLILGHEALAEVAALGKGVDNVSEGDLVVPTVRRPLDCQLPVDYCPPGKYLEHGIWGLHGHAAELSITDAAYLVKVPKELRDIAVLTEPLSVVEKGVELGVESYKARLGSPPKTALVLGAGPVGLLASMVLRLMGVSITAVATRPHDSLKARLVEELGGRYIDAVHERLEGEFDLVIEATGAPSLAVQGLERLAPGGVEVLLGVYPPTGELKGLGSLLTDAVLKNKLVVGSVNAGLRHFERALAHLKEANDSLNGFPKRLITKVVPLERYQEAYVWTHDDIKVVLQVQT
Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. To a lesser extent, is also active with xylose as substrate, but mannose, arabinose, galactose, fructose 6-phosphate, glucose 6-phosphate, glycerinaldehyde 3-phosphate, ribose, sorbitol, ethanol, erythritol, or lactose are not oxidized by the enzyme. Can utilize both NAD(+) and NADP(+) as electron acceptor, with a marked preference for NADP(+). Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway.
Q703W7
Q3SWX9
RAD21_BOVIN
64-kDa carboxy-terminal product
Bos
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLASTGASNLLLEPEQSTSNLNEKINHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNVSMGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFSLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREDQQQQHQQRDVIDEPILEEPSRLQESMETSRTNLDESAMPPPPPQGVKRKAGQIDPEPMIPPQQAEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEDDEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII
May promote apoptosis.
Q3SWX9
Q39I40
PDXY_BURL3
Pyridoxal kinase PdxY
Burkholderia cepacia complex
MKNVLSIQSHVIYGHAGNSAAVFPMQRLGINVWPLNTVQLSNHMQYGHWAGSAIDAAKMEQLVDGIAAIGALKRCDAVLSGFLGSPPQARAAVEIVRSVKAMNPNAWYFCDPAMGQTGGIRPEPGVEEFMVQEMPALADGMSPNHTELQKLAGRRIETVAEAVEACRALIRRGPQIILVKHLHDRNSPADRFNMLAVTETEAWIGQRPLYAFPRHPVGVGDLTSAIFVACRLRGDSVRAAFEHTLAAVHAVVKATYDARRYELELVAAQDEIARPSEWFGAWVTDA
Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP.
Q39I40
A0AFA6
RLMH_LISW6
rRNA (pseudouridine-N3-)-methyltransferase RlmH
Listeria
MNIQIITVGKLKEKYLVQGIAEYLKRLTAYAKVTIVEVPDEKAPEVLSDAEMKQVKDKEGVRILAKIPDDTHVIALAIDGKMKSSEEFAADLDKLATYGKSKVAFVIGGSLGLSESVLKRSDEQISFGRLTLPHQLMRLVLVEQVYRAFRIVRGEPYHK
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
A0AFA6
B1XYE7
GLYA_LEPCP
Serine hydroxymethyltransferase
Leptothrix
MFDRATQTLAAIDPEITAAIDAEVRRQEEHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEHVDVVEQLAIDRAKQLFGAQNANVQPNSGSQANQAVFFGLLQPGDTIMGLSLAEGGHLTHGMPLNMSGKWFKVVSYGLDAQEDIDYDAMERLAHEHKPKLIIAGASAFALRIDFERFAKVAKAVGAYFMVDMAHYAGLIAAGVYPNPVPFADVVTTTTHKTLRGPRGGLILMTDAVAKQINSAIFPGIQGGPLMHVIAGKAVAFQEALQPEFKAYQEQVVKNATAMAETLTARGLRIVSGRTESHVMLVDLRPKGITGKEAEALLGRAHITCNKNGIPNDPQKPMVTSGIRLGSPAMTTRGFKEEQAVLTANLIADVLEAPNDEAVLERVRAQVAQLTRDFPVYR
Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
B1XYE7
Q6CUQ5
CWC25_KLULA
Pre-mRNA-splicing factor CWC25
Kluyveromyces
MSDLNLLKSWNPKLVKNRKKVWEAQQQLVEENKKIKERQKEIEKERELDRYSSLIRDEDQKNVKRKTGLEWMYDNTSTALTENVDYLLGKKEITDTLLDLSGNNNKSEKSENQKQTIRKHYQGIEDVICSKTNHKNVDLSSDDPMAKFKAAKQAHLKTLKQNIQPTSHEYPVHKPLRGANSKRYDSGNGSRSNYKNSRYNNKYYRS
Involved in pre-mRNA splicing.
Q6CUQ5
Q6F9J2
PQQB_ACIAD
Pyrroloquinoline quinone biosynthesis protein B
Acinetobacter
MLIKILGSAAGGGFPQWNCNCENCLGLKQGTIQAKARTQSSIAISDNGKDWILCNASPDIAQQIAHNPELQAPSSIRRGTSIGSIILTDSQIDHTTGLLNLREGCPHQVWATPEVHEDLSTGFPIFNMLKHWNGGLVHHPIDIQTSFQVAVCEAIRFTPVPILSNAPPYSPYRHRPLPGHNIALWIEDTRTGHSLFYAPGLGQMDDSILSYMQRADCLLVDGTLWKDQELALLGVGKNTGQDMGHLALQEERGLIHLLSQFPKQRKVLIHINNTNPILNEDSVERATLKQLEIEVSYDGMLIEV
May be involved in the transport of PQQ or its precursor to the periplasm, in association with PQQ biosynthesis, but is not absolutely required for this synthesis.
Q6F9J2
A7FMW4
PRIB_YERP3
Primosomal replication protein N
Yersinia
MTTNRLVLSGTVCKTPVRKVSPSGIPHCQFVLEHRSTQQEAGFSRQTWCRMPIVVSGQQSQALTHSITVGSQLTVEGFISCHQGRNGLNKLVLHAEQIEFIDSGD
Binds single-stranded DNA at the primosome assembly site (PAS).
A7FMW4
Q04LD5
RLMN_STRP2
tRNA m2A37 methyltransferase
Streptococcus
MKPSIHSLAHQTMQEWVLEQGEKKFRADQIWEWLYRKRVQSFEEMTNLSKDLIAKLNDQFVVNPLKQRIVQESADGTVKYLFELPDGMLIETVLMRQHYGLSVCVTTQVDCNIGCTFCASDLIKKQRDLNNGEIVAQIMLVQKYFAERGQDERVSHIVVMGIGEPFDNYNNVLNFVCTINDDKGMAIGARHITVSTSGLAHKIRNFADEGVQVNLAVSLHAPNNELRSSIMKINRAFPIEKLFAAIEYYIETTNRRVTFEYIMLNEVNDSVEQALELAELLKNIKKLSYVNLIPYNPVSEHDQYSRSPKERVLAFYDTLKKKGGNCVVRQEYGTDIDAACGQLRSNTMKRDRQKAVAEVNP
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
Q04LD5
P07124
PYS1_NOSS1
Rod-capping linker protein
Nostoc
MFGQTTLGAGSVSSSASRVFRYEVVGLRQSSETDKNKYNIRNSGSVFITVPYSRMNEEYQRITRLGGKIVKIEQLVSAEA
Rod linker protein, associated with phycocyanin. Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer.
P07124
Q5M583
FOLD_STRT2
Methenyltetrahydrofolate cyclohydrolase
Streptococcus
MAIIMDGKALAVNMQEQLQEKVARLKEKEWIVPGLVVIMVGENPASQVYVRNKERAAKKAGFHSKTVNLSESISEEELIEVIEKYNQDPLFHGILVQLPLPNHISEMRILLAIDPKKDVDGFHPMNTGNLWNGRPQMVPCTPAGIMEILREYNVELEGKTAVIIGRSNIVGKPMAQLLLEKNATVTLTHSRTPHLAKVCNKADVLIVAIGRAKFVTEEFVKEGAVVIDVGINRDEEGKLCGDVDFDQVKEKVSMITPVPGGVGPMTITMLMEQTYQAALRSLKG
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Q5M583
P0DUL7
HKM9_ASPHA
Hancockiamides biosynthesis cluster protein 9
Aspergillus
MPATTRLITIYGATGNQGGGVARSLLKNPCFQVRALTRNPNSPASQELAGLGAEIRRADGFDSNSLLAAFEGSWGVFVNINSDDKAFRPAGPTEYDLGMKIVDMAAQAGVQHFVFSSGPSSTELTNGKIRMKAMEMKNKIERYARNNTQFQTVSFICAAWYLENFLVKEIAPLFGGFPFVADAEAFLTFRCPRWGGKEDVPFISISDDYGDIVQGLFLDPHRWNGHVVHGCSDILTFDELVTHFQNVTGQKARFQPLESWETFDTFGVPELEDTKLMFGLTQTTGGLYFGPEPSEKNTAAALKRATAAALGLPRDQQTLITVKGWFQKHFPVTPN
NmrA-like family domain-containing oxidoreductase; part of the gene cluster that mediates the biosynthesis of hancockiamides, an unusual new family of N-cinnamoylated piperazines . The NRPS hkm10 and the NmrA-like reductase hkm9 are proposed to convert two molecules of L-Phe to the intermediary piperazine called xenocockiamide A (Probable). Xenocockiamide A is then converted to hancockiamide D via a series of hydroxylations and O-methylations (Probable). The tyrosinase hkm6 may catalyze an aromatic hydroxylation, then the 2-oxoglutarate-dependent Fe(II) dioxygenase hkm4 and the FAD-dependent phenol hydroxylase hkm7 may catalyze consecutive hydroxylations to install 2 more hydroxy groups, and the methyltransferase hkm8 probably catalyzes two methylations using 2 molecules of S-adenosyl-L-methionine (SAM) (Probable). The NRPS hkm11 activates and transfers trans-cinnamate supplied by the PAL hkm12 to hancockiamide D and produces hancockiamide A . NRPS Hkm11 has the flexibility to tolerate the bulky hancockiamide G as a substrate and the absence of the acetyl-transferase hkm3 opens up the opportunity for hkm11 to introduce a second N-cinnamoyl moiety . The cytochrome P450 monooxygenase hkm5 catalyzes the methylenedioxy bridge formation, converting hancockiamide A into hancockiamide G . Hkm5 can also convert hancockiamide B into hancockiamide C, and hancockiamide D into hancockiamide H . The N-acetyltransferase hkm3 finally transfers an acetyl group to 1-N of piperazine, converting hancockiamide A into hancockiamide B and hancockiamide G into hancockiamide C .
P0DUL7
G5EBD7
6PGDH_GLUOX
6-phosphogluconate dehydrogenase, NAD(+)-dependent, decarboxylating
Gluconobacter
MRIGIIGLGRMGGNIAVRLTRHGHDVVVHDRTSEVTTSVVGRCEAGRATPADTLADMAKLLEGDEHRVVWVMLPAGAITEDCVQQLGGLLGRGDIIIDGGNTYYKDDVRRSAELAEKGISYVDVGTSGGVWGLERGYCMMFGGTKETAEYIDPILSALAPGIGDVPRTPGRDEAGHDPRAEQGYLHCGPAGSGHFVKMVHNGIEYGMMQAFAEGFDIMKSKNSPILAEKDRFELNMGDIAEVWRRGSVVSSWLLDLTAEALTRSETLNEFSGEVADSGEGRWTIEAAIEEDVPAPVMTAALFTRFRSRSGNNFAEKILSAQRFGFGGHVEKK
Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NAD to NADH.
G5EBD7
Q9CBY4
CLPP2_MYCLE
Endopeptidase Clp 2
Mycobacterium
MKLQNSQLQPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDRDITMYINSPGGGFTSLMAIYDTMQYVRADIQTVCLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPSLAGVIQGQFSDLEIQAAEIERMRTLMETTLSRHTGKDAAVIRKDTDRDKILTAEEAKDYGIIDTVLEYRKLSAQTV
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Q9CBY4
P37702
BGL38_ARATH
Thioglucosidase 1
Arabidopsis
MKLLMLAFVFLLALATCKGDEFVCEENEPFTCNQTKLFNSGNFEKGFIFGVASSAYQVEGGRGRGLNVWDSFTHRFPEKGGADLGNGDTTCDSYTLWQKDIDVMDELNSTGYRFSIAWSRLLPKGKRSRGVNPGAIKYYNGLIDGLVAKNMTPFVTLFHWDLPQTLQDEYNGFLNKTIVDDFKDYADLCFELFGDRVKNWITINQLYTVPTRGYALGTDAPGRCSPKIDVRCPGGNSSTEPYIVAHNQLLAHAAAVDVYRTKYKDDQKGMIGPVMITRWFLPFDHSQESKDATERAKIFFHGWFMGPLTEGKYPDIMREYVGDRLPEFSETEAALVKGSYDFLGLNYYVTQYAQNNQTIVPSDVHTALMDSRTTLTSKNATGHAPGPPFNAASYYYPKGIYYVMDYFKTTYGDPLIYVTENGFSTPGDEDFEKATADYKRIDYLCSHLCFLSKVIKEKNVNVKGYFAWSLGDNYEFCNGFTVRFGLSYVDFANITGDRDLKASGKWFQKFINVTDEDSTNQDLLRSSVSSKNRDRKSLADA
Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones. These toxic degradation products can deter insect herbivores. Seems to function in abscisic acid (ABA) and methyl jasmonate (MeJA) signaling in guard cells. Functionally redundant with TGG2. Hydrolyzes sinigrin and, with lower efficiency, p-nitrophenyl beta-D-glucoside.
P37702
Q2NQZ3
STHA_SODGM
NAD(P)(+) transhydrogenase [B-specific]
Sodalis
MQPKYDYDAIIIGSGPGGEGAAMGLTKRGARVAIIERYDNVGGGCTHWGTIPSKALRQAVSRIIEINQSPLHGNTRLPHTGFSDILCHADQVINQQTHMRQGFYERNHCQIFTGEASFVDEHQVQIHYGDNTTETLSAENIVIACGSRPYQPQDVDFDHPRIYDSDSILDLKHDPHHVIIYGAGVIGCEYASIFRGMNVKVDLINTRDRLLAFLDQEMSDALSYHFWENGVVIRHNEEYEEIKGLDDGVEVRFRSGKRMKADCLLYANGRTGNTDTLKLDKVELEADSRGLIKVNSMYQTAARHIYAVGDVIGYPSLASAAYDQGRIAAQVIIKGQANVQLIENIPTGIYTIPEISSVGKTEQELTAMKVPYEVGRAQFKHLARAQIVGMNVGSLKLLFHRETKQILGIHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
Q2NQZ3
O74547
BIT61_SCHPO
Target of rapamycin complex 2 subunit bit61
Schizosaccharomyces
MVGRGSFSSTSSASSINWIPKNTKTSIESVSNTISLSENGQNQDLETVTTKESNVGDSDTTENIKSPFNGQWPFSRRSSQSSSHPVFEETHWSKHSKRPGKLNVLTPTSPSNVNAEVQSISTKTQLSLLNLSPHKHKKPKDGLDLSALQKTLNGSRNFLRGRRDAGGIFGASIPQSLVTNQIINGFGAASLAFAKLGKVRSPLEGRFNLVPISADETWLIVESEVCSLYSGEALHYSLEDLNGILILHLQALIRDTKMNEFVGHLETLFRKATKCLSDSLSPVPEELFLNRIIETWLFFFSSVLPYVQGVFLPIKTKLFDEQEKTQLPYEVNEFCSTNREKLNVHRLALMTFRDYMVLPIANRIQICIGRAESAENALDNAGEVFARLFQILSLLASVRTNDSKEQEITNLATKVRCLLIAS
Component of TORC2, which regulates multiple cellular processes to control cell growth in response to environmental signals. TORC2 is required for cell survival under various stress conditions. TORC2 positively controls G1 cell-cycle arrest, sexual development and amino acid uptake. Positively regulates amino acid uptake through the control of expression of amino acid permeases.
O74547
P11638
QA1F_NEUCR
Quinic acid utilization activator
Neurospora
MPPKRKTLNAAAEANAHADGHADGNADGHVANTAASSNNARFADLTNIDTPGLGPTTTTLLVEPARSKRQRVSRACDQCRAAREKCDGIQPACFPCVSQGRSCTYQASPKKRGVQTGYIRTLELALAWMFENVARSEDALHNLLVRDAGQGSALLVGKDSPAAERLHARWATSRVNKSITRLLSGQAAQDPSEDGQSPSEDINVQDAGAKTSDFPHAPHLTFSAPKSSTAETRTLPGPVRPPISANTLENNLQPDGTGIGKLPPNHWRLLDIYFSYTHSWLPILEKKDMYQALYQYSEQGSLLPSANVESGVHAELWSALALASFQAAATAASSATGPASAAHGHDNAINPSPADISDTARKLIPLESGPFQVQHCRALLLLCLVSLGRDDWESAWLLVGFAVRVLLVVRTQLPPDDDRPRPRMRALLVACFIVDTIVSMRHNVPAHLKPDDIADLPLPEDGQDQWEPWTPCEGLGGEHTMLQMLRNPAYPLSTFNHLYGVTKLVALELLPRIRTSSQNAPLEFRSRLQQVIGHNSPFSVFVLSQDTASAFVPTAYLTRTVYLWAAAFSEPLNEHYSHLLIETLDQYQKRFGTYAIPPLIPSLLDSLLALKKQSHSSERHRRHLEELFPAYSSIWPRGGRHSNTGLQPIRQLELPPTATATASIMPHVMEQPLSTSINPVNDRFNGIPNPTPYNSDAALDAITQTNDYGSVNTHGILSTYPPPATHLNEASVALAPGGAPPRPPPPYVDSTTNHPPYHSNLVPMANFGYSTVDYDAMVDDLASIEYTDAVDVDPQFMTNLGFVPGCNFSDISTYEQ
Transcription activation of genes for enzymes and proteins of quinate metabolism by binding to a 16 base-pair sequence (consensus 5'-GGRTAARYRYTTAYCC-3') in front of each Qa genes.
P11638
P0CR07
DBP10_CRYNB
ATP-dependent RNA helicase DBP10
Cryptococcus neoformans species complex
MAAITPSWALETTADGEVKEKTSGPGGQWRALNVGPDLIRSLLIRKFKTPTPIQRAAIPPALSTPPRDILGMARTGSGKTLAYLIPLLQRTGSTHHGQGPRALILCPSRELAVQIYTVGKDLARGMNKGKGKGKNKNEDEEDEEGKGKEGLRWALIIGGEGMDAQFEKMSSNPDIVIATPGRFLHLIVEMHMDLRHLQTVIYDEADRLFEMGFDVQLQEILHRLPSTRQNLLFSATLPSSVAEFAKAGLVNPLLVRLDAEQKISPDLALKFFSVKPGEKEASLLVLLREVIGKPNQPEPADPSSAPQAIVFVATKHHVDYVAELLRTTGYRTSLIYSSLDQVARQQQLAGFRSHQSDVLVVTDVAARGLDIPIMDHVINYDFPAGPRIFVHRVGRTARAGRKGTAYSLIVKEDFPYLCDLHTFLGTERMGEPADVLRSLPIEQLSENVEYVFHNLDETAPHITALRNVMRKGQGMFERSRTKANPTSYRQAKSLASALSNNPPRIDDMFEDAMEVEVNEEKARLLAKVAAFTPSETVFEVGKRESESAIIMKKRRKTVDERQKRVSKAEAEKSTASGMEKAPVKELPAPQLPSKNFKDPSFYLDHTQRGAEAEKGYSLKSGVESLSGAITDMTADEGTGPKAQKASQLSWDRKKHKFIKKNGSADGEKMIKSESGALLPASYSSGKYQEWKSKRRHMPDGPVEALALGGGRRGRHGPPGQKRKAEDGDGGEDAGGKGRKDQGKSKGTGKGKDDFKQKSPGKPGKKGIKQSSGLKSAMDIRKQREIAQKRKEKNARKPQKFRK
ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.
P0CR07
B8ZUB2
PXPA_MYCLB
5-oxoprolinase (ATP-hydrolyzing) subunit A
Mycobacterium
MACIDLNADLGEGFGVWRLGDDEAMLRIVTSANVACGFHAGDPAGLLRVCRLAAERGVRIGAQVSYRDLVGFGRRFIDVTADDLLADVVYQIGALQAIAQTAGSAVSYVKPHGALYNTIVTNREQGAAVAAAIQLVDSTLPVLGLAGSTFFDEAARIGLRTVAEAFADRTYRPDGQLISRREPGAVLHDPAVIAQRVVTMVTTGKATAVDGTQLAVTVESICLHGDSPNAIQMATAVRDQLNAAGIDIRAFC
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
B8ZUB2
Q8BX43
TR19L_MOUSE
Tumor necrosis factor receptor superfamily member 19L
Mus
MSLQGLMMKRTLLCWPLSCLFVLLPWPLATPTPITPWLCPPGKEPDPDPGQGTLCRTCPPGTFSASWNSYPCQPHYRCSLQKRLEAQAGTATHDTMCGDCQHGWFGPQGVPHVPCQPCSKAPPSTGGCDESGRRGRRGVEVAAGTSSNGEPRQPGNGTRAGGPEETAAQYAVIAIVPVFCLMGLLGILVCNLLKRKGYHCTAQKEVGPSPGGGGSGINPAYRTEDANEDTIGVLVRLITEKKENAAALEELLKEYHSKQLVQTSHRPVPRLLPASPSIPHICPHHHHLHTVQGLASLSGPCCSRCSQKWPEVLLSPEAAAATTPAPTLLPTASRAPKASAKPGRQGEITILSVGRFRVARIPEQRTSSLLSEVKTITEAGPSEGDLPDSPQPGLPPEQRALLGSGGSHTKWLKPPAENKAEENRYVVRLSESNLVI
May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation .
Q8BX43
Q89AE7
OBG_BUCBP
GTP-binding protein Obg
Buchnera
MKFLDKAIIHVIAGNGGHGRTSFRREKYIPKGGPDGGDGGNGGNVWLQTVTNLNTLIDFKFTKIFKAQDGQQGFNKKKTGKKGSDIVIQIPIGTKIIDHNTNEIIEDMIQDKQLVLVAKGGWHGLGNTRFKSSTNRIPIKHTKGTQGEFRILRLELILIAHVGTLGLPNSGKSTLVRNISNAKTKIANYPFTTLKPVLGTVKINHKEFFVIADIPGLIQGASHGIGLGYQFLKHLERCHLLLHIIDISQINFKNTITNIHVILDELKTYNKILHNKPIWFVFNKIDLIDDIDINTKLKSILEKLGSIQQYFLISAIKKTGLKKIVKKIYDFLKNKNLL
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
Q89AE7
Q1WSN8
KUP_LIGS1
Probable potassium transport system protein kup
Ligilactobacillus
MKVKRKIFWGALITLGIVYGDIGTSPLYVMKALIMDAGGLNGLTEDYIIGCLSLVFWTLMLMTTIKYVLIALRADNHGEGGIFALYALVRNKKKWLILPALLGGAALLADGTLTPAVTVTSAIEGLKGISIGSQPWINTQLEVNLVTFVILLVLFLIQRFGTSFIGKAFGPLMLLWFSFLAIFGIVNLIHEPLVLRALSPHYGLMLLFSPANKVGIFILGSVFLATTGAEALYSDMGHVGKRSIYLTWPFVCGALVLNYFGQGAYLIKNLGNFKTTGDIFNPFYEMLPSSVYLFGVLISTIAAIIASQALITGSFTLVEEAVGLKLLPKMKVEHPSLSRGQIYIRTINWSLCICTLLVLVYFRTSERMEAAYGLAITITMLMTTILLSQYLKDKVNVVFNGIFLAVFLSVELIFLISSLTKFTHGGYVTLLITLLILLIMVIWYFGNKLRDYLSDEEEWVSLRDYKDVLQELSNDDRIPLYISNLVMLTKVDKRTYKVKRETLYSILDKSPKKAKVYWFVTVNTTSDPYTNYYTVDMMGTRNIVNLQLYLGFKMDHRVNLYLRQVVEDLIENDIIDEQPQKYTTMPGRKIGDFRFIIIQELLSPNTRVRGWQHLLISARIFIQNHSTNPIQWFGLEFSEVKVEKVPLLLKKRRIPAMEQRMILNPKDVKRSTKE
Transport of potassium into the cell.
Q1WSN8
Q9KSE5
BSR_VIBCH
Broad spectrum racemase
Vibrio
MHFKATLLSLSIAATLPSFSLSAAPLHIDTALPDAAQIQQSNSWLEISLGQFQSNIEQFKSHMNANTKICAIMKADAYGNGIRGLMPTIIAQGIPCVGVASNAEARAVRESGFKGELIRVRSASLSEMSSALDLNIEELIGTHQQALDLAELAKQSGKTLKVHIALNDGGMGRNGIDMTTEAGKKEAVSIATQPSLSVVGIMTHFPNYNADEVRAKLAQFKESSTWLMQQANLKREEITLHVANSYTALNVPEAQLDMVRPGGVLFGDLPTNPEYPSIVSFKTRVSSLHHLPKDSTVGYDSTFTTSRDSVLANLPVGYSDGYPRKMGNKAEVLINGQRAKVVGVTSMNTTVVDVTEIKGVLPGQEVVLFGQQQKQSIAVSEMENNAELIFPELYTLWGTSNPRFYVK
Amino-acid racemase able to utilize a broad range of substrates. Reversibly racemizes ten of the 19 natural chiral amino acids known, including both non-beta-branched aliphatic amino acids (Ala, Leu, Met, Ser, Cys, Gln and Asn) and positively charged amino acids (His, Lys and Arg). Among these substrates, is the most efficient with lysine and arginine. Is also able to catalyze the racemization of several amino acids that are not typically incorporated into proteins such as ornithine and norleucine. Is not active on negatively charged (Glu and Asp) or aromatic (Tyr, Trp and Phe) amino acids and displays minimal activity towards beta-branched aliphatic (Ile, Val and Thr) substrates . Enables bacteria to produce and release extracellular non-canonical D-amino acids (NCDAAs) that regulate diverse cellular processes which may function as part of a cooperative strategy in vibrio communities to protect non-producing members from competing bacteria . D-amino acid production by BsrV provides a cue for V.cholerae to decrease peptidoglycan synthesis and to alter its cell wall via incorporation of NCDAAs into the muropeptides, in adaption to stationary phase conditions .
Q9KSE5
Q43209
PIMT_WHEAT
Protein-beta-aspartate methyltransferase
Triticum
MAQFWAEGSLEKNNALVEYLKQYGVVRTDKVAEVMETIDRALFVPEGFTPYTDSPMPIGYNATISAPHMHATCLELLKDYLQPGMHALDVGSGSGYLTACFAMMVGPEGRAVGIEHIPELVVASTENVERSAAAALMKDGSLSFHVSDGRLGWPDAAPYDAIHVGAAAPEIPRPLLEQLKPGGRMVIPVGTYSQDLQVIDKSADGSTSVRNDASVRYVPLTSRSAQLQDS
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins. This enzyme does not act on D-aspartyl residues.
Q43209
Q96BM0
I27L1_HUMAN
Interferon-stimulated gene 12c protein
Homo
MGKESGWDSGRAAVAAVVGGVVAVGTVLVALSAMGFTSVGIAASSIAAKMMSTAAIANGGGVAAGSLVAILQSVGAAGLSVTSKVIGGFAGTALGAWLGSPPSS
Plays a role in the apoptotic process and has a pro-apoptotic activity.
Q96BM0
B5F287
TRMD_SALA4
tRNA [GM37] methyltransferase
Salmonella
MFIGIVSLFPEMFRAITDYGVTGRAVKKGLLNIQSWSPRDFAHDRHRTVDDRPYGGGPGMLMMVQPLRDAIHAAKAAAGEGAKVIYLSPQGRKLDQAGVSELATNQKLILVCGRYEGVDERVIQTEIDEEWSIGDYVLSGGELPAMTLIDSVARFIPGVLGHEASAIEDSFADGLLDCPHYTRPEVLEGMEVPPVLLSGNHAEIRRWRLKQSLGRTWLRRPELLENLALTEEQARLLAEFKTEHAQQQHKHDGMA
Specifically methylates guanosine-37 in various tRNAs.
B5F287
P05507
NU4LM_RAT
NADH dehydrogenase subunit 4L
Rattus
MTSAFLNLTMAFTLSLLGTFMFRSHLMSTLLCLEGMMLSLFVMTSTSTLNSNSMISMTIPITILVFAACEAAVGLALLVKISNTYGTDYVQNLNLLQC
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.
P05507
Q0TFH3
RBN_ECOL5
Ribonuclease Z homolog
Escherichia
MELIFLGTSAGVPTRTRNVTAILLNLQHPTQSGLWLFDCGEGTQHQLLHTAFNPGKLDKIFISHLHGDHLFGLPGLLCSRSMSGIVQPLTIYGPQGIREFVETALRISGSWTDYPLEIVEIGAGEIFDDGLRKVTAYPLEHPLECYGYRIEEHDKPGALNAQALKAAGVPPGPLFQELKAGKTIMLDDGRQINGADYLAAPVPGKALAIFGDTGPCDAALELAKGVDVMVHEATLDMAMEAKANSRGHSSTRQAAALAREAGVGKLIITHVSSRYDDKGCQHLLRECRSIFPATELANDFAVFNV
Zinc phosphodiesterase, which has both exoribonuclease and endoribonuclease activities.
Q0TFH3
A8W3E9
PSBN_CUSEX
Protein PsbN
Cuscuta subgen. Monogynella
METATLITIFLSGLLVSFTGYALYTAFGQPSQQLRDPFEEHGD
May play a role in photosystem I and II biogenesis.
A8W3E9
A1RAW1
DCDB_PAEAT
DCD-DUT
Paenarthrobacter
MLISDRDIRAEIDSQRIVLEPYDPAMVQPSSVDVRIDRFFRLFDNHKYAHIDPAEEQPELTRLVEVEGDEPFILHPGEFVLGSTYETVSLADDIAARLEGKSSLGRLGLLTHSTAGFIDPGFSGHVTLELSNVATLPIKLWPGMKIGQLCFFRLTSSAEHPYGSGEYGNRYQGQRGPTASRSHQNFHRTSI
Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
A1RAW1
A8ESZ6
URED_ALIB4
Urease accessory protein UreD
Aliarcobacter
MSIKFSFKDEVFSLDKLQLPSRHYHFNDNENYIKLLNIGEGIFPKDKIRTSLSLDNSNLIFTTESATKIYPSKKEYGIQKIDIVLKNNSNLEFINDELILYKDSRYIQFFNLKSDENSTFFYTDILSRGRSFENFDFSNMLIKNSFFCEKSMEYMEKFDVKGAELKDYINRKSSSNFIFAKIYIKTNNNEEFLNRIYLEKFESFTYTKNKKIILGVISSNNMFELKNQIFKIWELYRKELNKSKFNLGKQ
Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.
A8ESZ6
A8EV23
HTPG_ALIB4
High temperature protein G
Aliarcobacter
MAKHQFQTEVGQLLHLMTHSLYSNKEIFIRELVSNASDAIDKLNYLRLTDENLKDKYAQWKGEINISFDEKDKSLSIIDNGIGMNEADLIASIGTIAKSGTKSFVEALTGDAKKDSNLIGQFGVGFYSVFMVADKVDVISKKAGEEQAYKWSSTGTGEFDLTPCTKESNGTVIYIKLKDEEAGEFASKYRIKNIVEKYSNHIAYPIFLNYDEEVSEALSEEDEKAGKKPEKKIERKHEQINAATALWMQPKAKLKEQDYNDFYKSISHDSSDPMLTIHTKTEGVNEYTTLFYIPKIAPMDMYRADFQSGVKLYVKRVFITDDEKELLPTYLRFVRGIIDSEDLPLNVSREILQENRILANIKQGSVKKILAEIKKLSKDEEKYAEFVAQYIRPLKEGVYQDYTNKEAILELLRYKSSKTEAGKMTSLEAYKERANSEQKAIYYIVGENEKVLRNSPLLESYKKNDIEVLILDDKEIDEIITPAIGAFKEWEFKDITAIEPPKVEQSEEEKKEVEEKFQDILSKIKDKLGDAVKDVKVTSRLSESPSCVVKDAADAQMAAMAHMFRAMGQAMPESAPILEINPEHEIVKKLNGCADEATIEDVSWILLDQAKLSEGMEITDTVAFAQRLSRITAKAL
Molecular chaperone. Has ATPase activity.
A8EV23
B2AC45
MEP1_PODAN
Extracellular metalloprotease PODANS_2_14170
Podospora anserina
MRFSLALAAAGLAQTAFAAPQPSRGFGCGAPEPSEELLQVSQQFAVEEAQALAESYRSGNLTARDVTAQAISVKVYIHVVAASTALSGGYLTDTMINNQFSVLQSAFAPYGISFTLAGTDKTVNANWADDSKGYEMTMKRALRKGTYKDLNLYFLQKMGGNLGYCYFPTTASPGSTAYIRDGCTILYSTTPGGSSTNYNLGHTATHEVGHWFGLYHTFQGGCTGAGDSVSDTPAQASASSGCPVGRDSCPSQAGVDPIHNYMDYSIDSCYEEFTPGQQTRINSFWTSYRQNAS
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.
B2AC45
Q8CXB4
UVRC_OCEIH
Excinuclease ABC subunit C
Oceanobacillus
MNENIEKKLSILPQQPGCYLMKDKNGTVIYVGKSKKLRNRVRSYFRGANDRKTQRLVQEIRDFEYMVTSSEIEALILEMNLIKKYDPRYNVMLKDDKSYPYLKITSERHPRLIVTRRLKKDKGKYFGPYPNVIAARETKKLLDRMYPLRKCNNPSGRPCLYYHMGQCKACAENPPSVKEYQEIVQEISSFLQGGFKDIRKNLAGEMQKASEALNFERAKEIRDTIQHIDATMEQQKMTLTDQMDRDIFGYSYDKGWMCVQVFFIRQGKLIERDTSVFPFFDSPEETIVSFIGRFYLHENHLKPKQVLVPVGIDNELLAKVLEIQVHIPLRGRKKELVQLAVKNAEISLNEKFQLIEKDEERTIQAIEDLGEQLNIETPHRIEAFDNSNIQGTDPVSAMIVFEDGKPNKKEYRKYKIRDVKGPDDYDTMREVVRRRYSRVLKENLPLPDLIIVDGGKGQMSAALEVLEDELGLDIPLAGLAKDDRHKTSELLYGMPPIVVPLERQSQAFYLVQRIQDEVHRFAITFHRQLRGKSLFQSELDKIPGVGEKRRKLLLSHFKSINQIKKASIEDMRKLGIPSNIAELVLNHLNSPNDDET
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q8CXB4
Q7M8Z2
ISPG_WOLSU
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Wolinella
MQERVKTKKIFVGDVAIGGDAPISVQSMTFSKTADIGATKAQIDRLALAGCDIVRVAVSDHEDANALKELKRLSPLPLVADIHFRYKLALIAAQSVDCIRINPGNIGSKEKIKAVADACAERGIPIRIGVNGGSLEEMFEQKYGATPRGMVESALYNIKLLEDFGFANIKVSLKASDVERTVLAYRELRPLVEYPFHLGVTEAGTLFHSMIKSSMALGGLLLEGIGDTMRVSITGELEQEVEVARAILKYSGRQKEGVYLISCPTCGRIEADLVSAVKRVEERVKHIRAPLQISVMGCAVNALGEAKHADIAIAFGRGDGLIIKKGEILCKLPEEELVDRLVEEAEKLEREYLEDSFKN
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Q7M8Z2
Q9VKW2
PIE_DROME
Pineapple eye protein
Sophophora
MEDNKELQCLICKYSDTDDLVFGEWMIVRNLQVHYFCLLLSTHLPQRGGDSSGILGFLLRDIREEAAAAEKRKCWYCNKIGASLQCDRCRSLFHLKCGLENRAVFEFCGQYKSYCYKCRPMDDYKRQLQSNPPRNATCPICFSSIYKVELHCVVYGDCCRLGFAHKKCMRQYALTSGYYLRCIWCRSERFRDSIRLQSVFVPDRDATWEKQRNAYRELHERNLKCDQPNCLCPSGRTYNRLSWVILCCSSCAATSAHLKCLVGALRLPKKRERTDFKCSMCLDVERRIAEGPARTTEETNADGDNQVDGSFYVQKLGPDAATRSLTQTPVFSEEDESERSSNITVIFSQPKSNATSERLSLSPPQEEMIVEIPDSPEASPKTSIDENHSPQPIARRDTSDSPQPIAASEIPDSPQPTAASEIPDLPQTTAINVNPELTQQTALNTIPHSPQPEASFSTQLVSQTFDCPQPQEQAVAKAPNSPSLPKEDPNTLLVLKSGFQCPGEPFFYLVIYEFEHGTCMGECIGTCVLRFKEDDPRIQDTSQAALERVNITPDDVWCRSEDRGIFEHIEKFHEWYRSEGFS
Required for survival of imaginal disk cells possibly by regulation of cell apoptosis . Required for germline stem cell self-renewal through mediation of BMP signaling .
Q9VKW2
C4L690
GATA_EXISA
Glutamyl-tRNA(Gln) amidotransferase subunit A
unclassified Exiguobacterium
MSLFDHGVAKLHTLLKEGEVTVTDLVKESFDRIEATDDQIGAFLTLNEDAFEQAKRMDELAKMSDNPLFGMPIGVKDNIVTKGMRTTCASTFLENFVPAHDATVVERLHDAGALTIGKLNMDEFAMGSSNENSAFKPVRNPWDPTRVPGGSSGGSAASVAAGQVLFSLGSDTGGSIRQPAAYCGVVGMKPTYGLVSRFGLVAFASSLDQIGPLTRTVEDNAYLLNTIAGHCDMDSTSAEVEVPDYTAALNQDLTGMKFALPEEFMAEGVAPGVREQIEKAIETLKSLGATIETVSIPSVKYALSAYYLLASSEASSNLARFDGIRYGRRAEADTLDEVFTYSREQGFGDEVKRRIMLGTYALSSGYYDAFYKKAQQVRTLMKQDFAKVFEEYDAIVGPTAPTTAFKLGEQLDDPLTMYANDIMTIPVNLVGIPAISVPAGLSEGLPVGLQIIGNYFDESTLYRVAHAFEQANGGFKMPQL
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
C4L690
Q06GS9
MATK_PIPCE
Intron maturase
Piper
MEKFKRYLETFRSEQKYFLYPLLFQEYIYALGHDHGLNGPIPYESIENLGYGDKSSSLIVKRLIIRMHKQNHFLISCNENDFQQNRLLGRKNNLDSKIISEAFSIIVEIPFSFQLVSCLEKKREIAKSHNLRSIHSIFPFFEDNIFYLYHISDVLIPYPIHPEILVQTLRYWIQDVPSLHLLRIFLYEYCHSGSFISKKKFFSFSKKENERLSLFIYNSYVYEWESIFLFIRKQSSHLRSISWEALLERVHFYGKIEHLVVVLCNDFQKALWVFKDCFMHYVRYQGKSLLISKGTDLLMKKWKYHFIYLWQCNFHLWSQPHRIHINQLDNRSFHFLGYASSVRINLSVVKSQILENSFLMETSVKKFETTVPIISLIGSLSKEKFCNLSGHPTSKAIWADSSDSDIMERFGRVCRNLSHYYSGCSKKQILYRIKYILRLSCARTLARKHKSTVRVFLKRLGSGFLKEFLAEEEQVLSFFFPRSYPTSYRSNKDKERIWYLDITHTNDLANHE
Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Q06GS9
B0VYX4
COX5A_PONPY
Cytochrome c oxidase polypeptide Va
Pongo
MLGAALRRCAVAAATRAGPRGLLHSTRTPGPAAAIQSVRCYSHGSQETDEEFDARWVTYFNKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNDFASTVRILEAVKDKAGPHKEIYPYVIQELRPTLNELGISTPEELGLDKL
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
B0VYX4
B0BTV5
SUCC_ACTPJ
Succinyl-CoA synthetase subunit beta
Actinobacillus
MNLHEYQAKQIFAQYRLPVSKGIVCHSLDDAVSAIHTLAGDTWAAKCQVHAGGRGKAGGVKLVRSEAEIREFCHQWLGQRLVTFQTDKNGQLVNTIYLEETCLIERELYLGAVIDRSSQKIVFMASNAGGMNIEDVAAQTPELIHKATIDPLTGAQAFQGRELAFKLGLSGDQIKQFAHLFVQLAKLFIEKDLALLEVNPLVLTKQGQLLCLDAKMVIDSNALYRHPELKALQDPSQEDAREADAAKWDLNYVALDGNIGCMVNGAGLAMGTMDIVKLHGGRPANFLDVGGGATKERVSEAFKLILSDQNVKAVLVNIFGGIVRCDLIAEGIIAAVNEVGINIPVIVRLEGTNAELGREILANSGLRLIAANTLTQAAQLAVKAAEGK
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
B0BTV5
Q76K27
SIAT2_MOUSE
Sialyltransferase 2
Mus
MKPHLKQWRQRMLFGIFVWGLLFLAIFIYFTNSNPAAPMPSSFSFLERRGLLPLQGKQRVIMGALQEPSLPRSLDASKVLLDSHPENPFHPWPGDPQKWDQAPNGFDNGDEFFTSQVGRKSQSAFYPEEDSYFFVADQPELYHHRQGALELPSPGETSWRSGPVQPKQKLLHPRRGSLPEEAYDSDMLSASMSRAFLYRLWKGAVSSKMLNPRLQKAMRYYMSFNKHGVRFRRRGRREATRTGPELLCEMRRRVRVRTLDGREAPFSGLGWRPLVPGVPLSQLHPRGLSSCAVVMSAGAILNSSLGEEIDSHDAVLRFNSAPTRGYEKDVGNKTTVRIINSQILANPSHHFIDSALYKDVILVAWDPAPYSANLNLWYKKPDYNLFTPYIQHRRKYPTQPFYILHPKFIWQLWDIIQENTREKIQPNPPSSGFIGILIMMSMCKEVHVYEYIPSVRQTELCHYHELYYDAACTLGAYHPLLYEKLLVQRLNTGTQADLHHKGKVVLPGFQTLRCPVTSPNNTHS
Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
Q76K27
B2SYV2
OBG_PARPJ
GTP-binding protein Obg
Paraburkholderia
MKFIDEARIEVIAGDGGDGSASMRREKFVPFGGPDGGDGGRGGSVIAVADRNINTLIDYRYAKKHLARNGENGRGADCYGKGGDDITLRMPVGTTITDMETGELIADLTEHNQSVQIAQGGAGGLGNLHFKSSTNRAPRQKTDGKPGERRMVRLELKVLADVGLLGMPNAGKSTFIASVSNAKPKIADYPFTTLAPNLGVVRVGPSRSFVIADIPGLIEGAAEGAGLGHQFLRHLQRTGLLLHIVDLAPFDDAVDPVAEAKAIVNELRKYDELLYEKPRWLVLNKLDMVPEDEREARVSAFLEGFGWDGPVFEISALTGQGCENLCYAVFDHISAHSDAQRAAEAEDLAADVRFREKPQAPAAADDAGTDPQV
An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.
B2SYV2
O35586
IDI1_MESAU
Isopentenyl pyrophosphate isomerase 1
Mesocricetus
MPEINTSHLDEQQVQLLAEMCILIDENDNKIGADTKKNCHLNENIDKGLLHRAFSVFLFNTENKLLLQQRSDAKITFPGCFTNSCCSHPLSNPGELEENDAIGVKRAAQRRLKAELGIPLEEVDPNEMHYLTRIYYKAQSDGIWGEHEIDYILFLKKNVTLNPDPNEIKSYCYVSKEELKELVKKAASGEVKLTPWFKIIVDTFLFKWWDNLNHLSQFVDHEKIHRM
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
O35586
Q0ZJ40
PSBA_VITVI
Photosystem II Q(B) protein
Vitis
MTVILERRESESLWGRFCNWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAAAAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANAGYRFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADIINRANLGMEVMHERNAHNFPLDLAAVEAPSING
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. The D1/D2 (PsbA/PsbA) reaction center heterodimer binds P680, the primary electron donor of PSII as well as several subsequent electron acceptors.
Q0ZJ40
B1WUG7
AROE_CROS5
Shikimate dehydrogenase (NADP(+))
Crocosphaera subtropica
MSIITGKTKLLGIIGHPVEHSLSPVMQNAEIKRLGVDYIYIPFPVKPENLETALDGFATIGVMGFNATIPHKQAIIPLLSEVTTTAKLVGAVNTVWRTEIGWKGTNTDVIGFVTPLKALNRDWNTIKPIILGNGGAARAVVVGLAELGCRDICVVGRDKDKLGQFKQSWDTSELQASITVHSWDELSGMVSESQLIVNTTPIGMFPHTQNSPVDSNLWEKLPNNAIAYDLIYNPSPTQFLKDAKQQGLTVIDGLDMLVYQGAAALEIWLQQPVSATVMSEALKQSLFS
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
B1WUG7
Q0BPL3
GLGA_GRABC
Starch [bacterial glycogen] synthase
Granulibacter
MRVLNVASEAYPWIKTGGLADVAGALPAALAEHDVDMRTLLPAYAGLRQRPETRPVHHYADLFGGAASILEARLTGGLTLYLLDAPHLYDRPGGPYTDANGRDWADNAERFAAFCRAAADIALGILPDWTPDIVHAHDWQAGLVPAYLALSEASPRPPVLFTIHNLAFQGVVPRDRLAALLLPPDSFSVDGVEYYGQIGLLKAGLHYADALTTVSPSYAREIQTDTGGMGLGGLLRDRAAVLNGLLNGIDMTEWNPAHDPHVKAHFDRHSLEHRTINREALRTRFGLDSSAGPLFGIVSRLTGQKGIDLVLNALPFLISQQAQLVVLGSGDKGLEQGLLQAAQTHPRQIAVFSGYDEALSRQIFSGADAMLIPSRFEPCGLTQLYAMRYGAVPIVSRVGGLADTIIDANTAACEAGVATGLMFQPDGEDSLIEPLSRAIRLFHQAEIWERLQHRGMETDSSWTLRSTAYVALYTRLLSLR
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
Q0BPL3
Q58670
DPHB_METJA
Diphthamide biosynthesis methyltransferase
Methanocaldococcus
MLILAGLGLYDENDMTLKTLKFAKKAEKIYAEFYTAVLTGTTTEKIEEVLGKKIHVLSRKDVEYNGYKLIEEAKDKDIMFLTAGDPMVATTHVDLAIEAKKKGIEVLIINAPSIYSAVGITGLQLYKFGKTTSIVFPEENYFPETPYNVIKENLERGLHTLCLLDIRIDENEKRFMTANEGLKVLLELENRKKEGIINEDTKAVVVARAGSLKPKLVYGKIKDLINYDFGEPLHCIIIPGKLHFMEEDALKYLCENI
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.
Q58670
O82381
U71C1_ARATH
UDP-glycosyltransferase 71C1
Arabidopsis
MGKQEDAELVIIPFPFSGHILATIELAKRLISQDNPRIHTITILYWGLPFIPQADTIAFLRSLVKNEPRIRLVTLPEVQDPPPMELFVEFAESYILEYVKKMVPIIREALSTLLSSRDESGSVRVAGLVLDFFCVPMIDVGNEFNLPSYIFLTCSAGFLGMMKYLPERHREIKSEFNRSFNEELNLIPGYVNSVPTKVLPSGLFMKETYEPWVELAERFPEAKGILVNSYTALEPNGFKYFDRCPDNYPTIYPIGPILCSNDRPNLDSSERDRIITWLDDQPESSVVFLCFGSLKNLSATQINEIAQALEIVDCKFIWSFRTNPKEYASPYEALPHGFMDRVMDQGIVCGWAPQVEILAHKAVGGFVSHCGWNSILESLGFGVPIATWPMYAEQQLNAFTMVKELGLALEMRLDYVSEDGDIVKADEIAGTVRSLMDGVDVPKSKVKEIAEAGKEAVDGGSSFLAVKRFIGDLIDGVSISK
Possesses quercetin 7-O-glucosyltransferase and 3'-O-glucosyltransferase activities in vitro. Also active in vitro on benzoates and benzoate derivatives. Glucosylates other secondary metabolites in vitro like trans-resveratrol, curcumin, vanillin and etoposide.
O82381