accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q981X2
DADA3_RHILO
D-amino acid dehydrogenase 3
Mesorhizobium
MPKIVVIGAGIAGVSTAYALLEQGYDVTVVERRRYAAMETSFANGGQLSASNAEVWNHWSTVLKGIKWMLRRDAPLLMNPTPSWHKYSWLLEFVSNISRYRENTIETTRLAIAARKHLFEIADREGIDFDHVRRGILHVYWDKDGFDHALKVNEMLNEGGLDRRSVTPSEFAGIEPALHGKFYGGFYTPSDSTGDIHKYCAGLEKACTKRGAQFIYDAAVTRIERRDRFNIVCATDGADQTLVADGIVVCAGTNSRDIAAMFGDRINIYPVKGYSITVELDGAAADSSAPWVSILDDRAKIVTSRLGAARLRVAGTAEFNGVNFDIREDRIRPLVDWTRMMFPKVATEHVVPWAGLRPMMPNMMPRVGKSRVPGVFYNTGHGHLGWTLSAATSAMLATVVATDLPIDARLAA
Oxidative deamination of D-amino acids.
Q981X2
Q75D04
YEL1_ASHGO
Guanine-nucleotide exchange factor YEL1
Eremothecium
MRSNHLFFRKVMTRLEVHPLNNSRLFCISDSSSTSLYSEPSKGSTIFAQQALDRFDWDLSIGETAFENMTDDAKMRNDPGMLVGPDGMLITPELLIASPGKIDVFDCASLDDTAGALEGMSLASGEGSNCMQAMRPRSETRSTNTTTSRSVAKQILRNTYGPVRYKDYANYLGSPENREVLREFIALLQPLPVSLLFSLRKLSKSIYFIAEAGAIDAMLEEMSIQWVERHKPLHYQDNYKLVHIVLFSLLILNSDLYNDMAQMKFTSAQFVDNTVYALLRESPTIDKQSFEAELRVYYDLLAMDQLPLHKPPITASHSRDSANPTKKSSVFYSRGHRMERTYSNSSTYSMSTISLQRTTTAIAAKQTAAVASWRFHNFSDLPLIYCKEPFDDEMNNTNDSSWLMDHIIQFQEPLGSVSRAAAASMVSPTAQPRRKLFNWLKKGQPDSIFKSHHEFGSAEGKWYNARVRISEGRLYIFNFKNQPALDPKTADLELCRRRAASYTVQNLFGAMATFVQDNIVYKSNSQTTWNFAITFPKTIDCETERTYQFQTSNMTMAQRFVQAATFWSARITPLPSAQFEMVSNQEYGWGEKLLSRQVAATDVRLTDWMPLIGIDSIYDEIEDSGDLTVDSQLQNLRVFTEHLTQLLDQHNSYKPKMVEIWTQNPSTQQFEMAMENWNRRYLYLNSMYEKHYTYLRALETAFETVTG
Guanine nucleotide exchange factor for ARF3 required for localization of ARF3 to the bud neck and tip and involved in actin patch polarization.
Q75D04
A6VJ39
COFD_METM7
2-phospho-L-lactate transferase
Methanococcus
MKITILSGGTGTPKLIQGFKEILPNEDISVIVNTGEDTYIGDIYLSPDIDTVLYTFSDLINDETWYGLKGDTFFCHEQLKNFGFDEVLKIGDKDRALKMHKASSLKNGVKMSEIVDIERKSLLINSKIYPMSNEKVESKVLIEENNEKILLKFHDFWIFRKGNAKVLDIFYENSNYAKAANGVLKAIHESDFVLIGPSNPITSIGPILSISEIKNALKEKLVFAVSPIVGENPVSGPAGTLMNAKGYPVSAVGVYEYYKDIVDVLVLDNSDINKKKDINCEVLYANTIMKTIDDKINLARNILDYYKSR
Catalyzes the transfer of the 2-phospholactate moiety from (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and GMP.
A6VJ39
A1VD51
COXX_DESVV
Heme O synthase
Desulfovibrio
MGRCTIADVAMLIRWRVSLMVAGATFFGAMLAVPHVTITHLLASLATFLLAGGCSAINQVQEADLDAVIPRTASRPIPCGRIGHMYGSLMGLALVTVGWMVLCLAGGLTSLLVGIGIVAVYNGLYTPLKRRTSFALLVGAAAGAMPPVVGWLAVGGHPASPMLVVVYTLYLLWQIPHFWLHAARDREAYRKARLPLPLLSLPHERYARLLKVWFHAYAVAVLMVPAFPLLEGVGMRIMVTLCGIALLFAAMLAVRKRRVALHIADAVLCAVMVVLLIDRLAIPVSLF
Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
A1VD51
Q1GK18
RL24_RUEST
50S ribosomal protein L24
unclassified Ruegeria
MAAKLRKGDKVVVLAGRDKGKEGTIASVDPKAGKAVVDGVNMAIRHTRQTQTSQGGRLPKALPIDLSNLALLDSNGKATRVGFREEDGKKVRFAKTTGETV
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.
Q1GK18
B0U009
FOLD_FRAP2
Methenyltetrahydrofolate cyclohydrolase
Francisella
MTLIDGKKLSIDLKERLTDQLREYKEQTGIVPKLVAIIVGDDPASKTYVGSKEKACEKVGINSEVITLPEATTEQELLELIDKLNDDSSVHAILVQLPLPTHINKQKVIYAIKPEKDVDGFHPANVGRLQLRDKKCLESCTPKGILTMLKEYGIQTEGAHAVVVGASNVVGKPVSQLLLNAKATVTTCHRFTKDLKSHTTKADILVVAVGKPGFITADMVKDGAVVIDVGINHVDGKIVGDVDFEAVKDKVAAITPVPGGVGPMTITELLYNTFQCAQELNR
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
B0U009
C5J411
XYNC_ASPNG
1,4-beta-D-xylan xylanohydrolase C
Aspergillus subgen. Circumdati
MVQIKVAALAMLFASQVLSEPIDPRQASVSIDTKFKAHGKKYLGNIGDQYTLTKNSKTPAIIKADFGALTPENSMKWDATEPSRGQFSFSGSDYLVNFAQSNNKLIRGHTLVWHSQLPSWVQSITDKNTLIEVMKNHITTVMQHYKGKIYAWDVVNEIFNEDGSLRDSVFYKVIGEDYVRIAFETARAADPNAKLYINDYNLDSASYSKLTGMVSHVKKWIAAGIPIDGIGSQTHLSAGGGAGISGALNALAGAGTKEIAVTELDIAGASSTDYVEVVEACLNQPKCIGITVWGVADPDSWRSSSTPLLFDSNYNPKPAYDAIANAL
Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.
C5J411
Q32ZH6
DFB15_RAT
Defensin, beta 15
Rattus
MKTFLFLFAVFFFLDPAKNAFFDEKCSRINGRCTESCLKNEELIALCQKNLKCCVTVQPCGRDKGDELDEDSGYNRTRG
Has antibacterial activity.
Q32ZH6
Q2T0K3
KDSB_BURTA
CMP-2-keto-3-deoxyoctulosonic acid synthase
pseudomallei group
MTSPLPFVAVVPARLASTRLPNKPLADLGGKPMVVRVAERAREAGAQQVLVASDAQSVLDAVREHGFDAVLTRADHPSGTDRLAEVAAKLGFSDDTIVVNVQGDEPLIDPQLVCDVASHLAAHPSCAIATAAHPIHEAHEVFNPNYVKVVLDANGVALYFSRAPIPWSRDAYLPHWPNIAAMPAPTCPVYRHIGLYAYRARFLRTYPTLAQAPIEAAEQLEQLRAMWHGERIAVLVTEHAPEAGIDTPADLERVQALFRSRAK
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
Q2T0K3
P37326
INTS_ECOLI
Putative prophage CPS-53 integrase
Escherichia
MLTVKQIEAAKPKEKPYRLLDGNGLYLYVPVSGKKVWQLRYKIDGKEKILTVGKYPLMTLQEARDKAWTARKDISVGIDPVKAKKASSNNNSFSAIYKEWYEHKKQVWSVGYATELAKMFDDDILPIIGGLEIQDIEPMQLLEVIRRFEDRGAMERANKARRRCGEVFRYAIVTGRAKYNPAPDLADAMKGYRKKNFPFLPADQIPAFNKALATFSGSIVSLIATKVLRYTALRTKELRSMLWKNVDFENRIITIDASVMKGRKIHVVPMSDQVVELLTTLSSITKPVSEFVFAGRNDKKKPICENAVLLVIKQIGYEGLESGHGFRHEFSTIMNEHEWPADAIEVQLAHANGGSVRGIYNHAQYLDKRREMMQWWADWLDEKVE
Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
P37326
B5FHV3
PAT_SALDC
Putrescine--2-oxoglutaric acid transaminase
Salmonella
MNRLPSSASALACSAHALNLIEKRTLNHEEMKALNREVIDYFKEHVNPGFLEYRKSVTAGGDYGAVEWQAGSLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVQNQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFCNSGTESVEAALKLAKAYQSPRGKFTFIATSGAFHGKSLGALSATAKSTFRRPFMPLLPGFRHVPFGNIDAMSMAFSEGKKTGDEIAAVILEPIQGEGGVILPPQGYLTEVRKLCDEFGALMILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGATIATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLEQNLPAQAEQKGDTLLDGFRQLAREYPNLVHDARGKGMLIAIEFVDNETGYRFASEMFRQRVLVAGTLNNAKTIRIEPPLTLTIELCEQVLKSARNALAAMQVSVEEV
Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal. Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.
B5FHV3
P07677
ATPB_BACP3
F-ATPase subunit beta
Bacillus
MTRGRVIQVMGPVVDVKFENGHLPAIYNALKIQHKARNENEVDIDLTLEVALHLGDDTVRTIAMASTDGLIRGMEVIDTGAPISVPVGQVTLGRVFNVLGEPIDLEGDIPADARRDPIHRPAPKFEELATEVEILETGIKVVDLLAPYIKGGKIGLFGGAGVGKTVLIQELIHNIAQEHGGISVFAGVGERTREGNDLYHEMKDSGVISKTAMVFGQMNEPPGARMRVALTGLTMAEYFRDEQGQDGLLFIDNIFRFTQAGSEVSALLGRMPSAIGYQPTLATEMGQLQERITSTAKGSITSIQAIYVPADDYTDPAPATTFSHLDATTNLERKLAEMGIYPAVDPLVSTSRALAPEIVGEEHYQVARKVQQTLERYKELQDIIAILGMDELSDEDKLVVHRARRIQFFLSQNFHVAEQFTGQPGSYVPVKETVRGFKEILEGKYDHLPEDRFRLVGRIEEVVEKAKAMGVEV
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
P07677
Q9VVF7
MIP_DROME
MIP-5
Sophophora
MAHTKTRRTYGFLMVLLILGSACGNLVASGSAGSPPSNEPGGGGLSEQVVLDQLSESDLYGNNKRAWQSLQSSWGKRSSSGDVSDPDIYMTGHFVPLVITDGTNTIDWDTFERLASGQSAQQQQQQPLQQQSQSGEDFDDLAGEPDVEKRAWKSMNVAWGKRRQAQGWNKFRGAWGKREPTWNNLKGMWGKRDQWQKLHGGWGKRSQLPSN
Ligand for the sex peptide receptor (SPR) . Stabilizes sleep and maintains sleep homeostasis to inhibit the activity of wake-promoting circuits, such as those that involve the pigment dispersing factor (pdf) neurons. Regulated by the circadian clock network and pathways associated with a sleep homeostat . May also have a regulatory role in gut motility .
Q9VVF7
Q9P3A8
CAND1_SCHPO
Cullin-associated and neddylation-dissociated protein 1
Schizosaccharomyces
MEEGILLKKYVESSDKDIRYMALSDLAARLNDANHLKNLKLESFPDTLDVLLQALSDASPEVQQEAVRCVAIISSKIPQDKLKSTVENLLSGVAGKKSKNYLSALSLLLSNSNVQPFVNKFYTSTVFPSFLQILKQYNVAQEEFFAILCVVCDSLEIYHSNLSTLLPNNFELCIDVFQKCTTQCQRELIIKKACYLLSDVSLYGPRFAYKYIIEVLDRGLGPSTQMSEVNISIKLLNEILLSSKKEKDSSTSFISTAVADYTNKILSLLKKEEAPDELTQKLLEVLGLLLEYQQVNILKIWPELHGLLISKISYDPNLISDTNDEDDIADFLEEMSDYSSIYEDEEDVSWIVRRESLKVVLSVILSRLEYLPIVLQALGTSVVSKLNDREESVCLISIEVLKQAFLHVPRWIEVYATSNDRKRRYEGLPSDRSAISDTSIYLVSVIGKHVSKLSDKTPLSIVSELLNLVTVIFSSRDLGVQSEFSNLSSIIYRFPDFSTLDIKIKLNLVRLISAIISCGCEEIENMESKMSTILSLAVQNNYPQLSYEALITELSFCKYIHKKQPTNVSTDFSTMIDSSLQLLESKISDLKVRLALIDLVSQYVILFYEPDFDSIFLRRVLIILCKKLQEEPTRSAAARALCDIFMSVTDITKIENGTKIYEEILQDCCRHIDKSGNEFTTAYLELLEVLLKVGQKYLAESLLEHILGLLIETLKRNTENTVAILKCLLIIPLSILLKSKNLLIDTIISHLQSSTIHLNEESVCLLSRIIAVISKEEDLELIINSFTCAQKPVEEMVTLALIAAQLICIFQSKAIVTSLNKSFMSPKSEVRIKVFTTLIFGQLDYGKLTLPANEYFDTIASNLNSPNADVMKAAAIALGSLTSQSEKFIKELCALYVSDAYDKELLLISFLTFLKKSKIDYETADKIWDILSKDIENIKDFSTSPFRTLLSECLGLLICNESSSLYYKLELLSSSEASNHMLLSLSVFRFSLTLDCPKLKAYEKQFFEKAYKLFQNPDLEVSQETLQVIISVIKNRRSCIADVYNELLQGLISKSSVDSSNVHVVQMGPFQHVVDNSINQRQLVFETLYSLLDIPESLNHLTHFLQVSVMGLEDEHYIKLVSLSILEKLVDCSPSIIDEQVDTILEALRKIIELRKTEKTLKTDSDNILDLVRSALRVLFTMKLKCDNPVISEFESQVQKGPYSLEYEGIKNEIKTTIKT
Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable).
Q9P3A8
Q21IY3
LEUC_SACD2
Isopropylmalate isomerase
Saccharophagus
MGGKTLYDKLWDDHLVQQRDDGSALLYIDRHIVHEVTSPQAFEGLRLAKRKPWRVDSVVATPDHNVPTTQKERASGVEGIEDPTSRIQVQTLDSNCDELGILEFKINDARQGIVHVVGPETGACLPGMTIVCGDSHTSTNGALGALAMGIGTSEVEHVLATQCLVAKKMKSMLVKVDGKLGAGVTPKDVVLAIIGKIGTAGGTGYAIEFGGEVMRSMSMEGRLTVCNMAIEAGARAGMVAVDDITIDYVKGRSFAPKGEHWEQAVAAWRDLKSDDDAVFDAVVELRGEEILPQVSWGTSPEMVLPVDASIPDPELETDAVKQNGMRRALQYMGLKAGQAIKDIYVDRVFIGSCTNSRIEDIRAAAEVVKGRTKAASVKEAIVVPGSGAVKAQAEAEGLDKIFVEAGLEWREPGCSMCLAMNADKLGDGEHCASTSNRNFEGRQGYGGRTHLVSPAMAAAAAIAGHFVDVREF
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
Q21IY3
A4WSP1
EFTS_CERS5
Elongation factor Ts
Cereibacter
MAITAQMVKELRESTGAGMMDAKKALTETDGDMEAAVDWLRTKGLAKAAKKAGRTAAEGLVGVAVSGGTGVAVEVNSETDFVAKNADFQTMVTGFTQAALSVDDVEALKAADMGGKTVETTLQETIAVIGENMTLRRMAKISGDSVAAYVHNAAADGLGKIGVLVAVKGADNGIAKQIAMHIAATSPMALSEADLDPTLVERERAVQTQKALEENAASAKPKPDSVIENNIIPGRMKKFLEENTLLGQKFVINPDVTVAEAAKQAGVEILGFVRMAVGEGIEKEKEDFAAEVAKTLAG
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
A4WSP1
B0BUA7
ERA_ACTPJ
GTPase Era
Actinobacillus
MTEQNQQPKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIHTEDQYQAIYVDTPGLHIEEKRAINRLMNRAASSAIGDVDLIIFVVEGTKWTDDDEMVLNKLRAAKAPVVLAINKVDNIKEKDELLPHITELSQKFDFAEILPISAQRGKNVHILQKIVRKSLREGVHHFPEEYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKLNERGTYEINGLILVEREGQKKMVIGVKGQKIKTIGMEARADMERLFDNKVHLELWVKVKAGWADDERALRSLGYMDE
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
B0BUA7
A4YBY0
RL2_SHEPC
50S ribosomal protein L2
Shewanella
MAVIKCKPTSPGRRHVVKVVNTDLHKGKPFAGLLAKKSKSGGRNNTGRITVRHVGGGHKQHYRLIDFKRDKDGIPAKIERLEYDPNRTANIALVLYADGERRYILAAKGMQAGDKIQSGVEAEIKTGNAMPLRNIPVGSVVHAVEMKPGKGAQIARSAGAYVQVVARDGAYATLRLRSGEMRKVPVDCRATFGEVGNAEHMLRQLGKAGAKRWRGIRPTVRGVAMNPVDHPHGGGEGRTSGGRHPVTPWGVPTKGYKTRSNKRTDKYIVRRRNK
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
A4YBY0
B0TM11
RL4_SHEHH
50S ribosomal protein L4
Shewanella
MELVLKDAQSALEVSEATFGRDFNEALVHQVVVAYAANARQGTRAQKTRAEVTGSGKKPWRQKGTGRARAGTVKGPIWRGGGVTFAAKTQDHSQKVNKKMYRGALKSIFSELVRQDRLIVVESFGVDAPKTKELKAKLDAMQLQDVLIVTPEVDENLFLAARNLYKVDVRDVAGVDPVSLIAFDKVLVTAEAIKQIEEMLG
Forms part of the polypeptide exit tunnel.
B0TM11
A2V7M9
PGAP3_CRIGR
PER1-like domain-containing protein 1
Cricetulus
MAERTARLLLLTVTVGLAWGSQGDREPVYRDCVLRCEERNCSGDALKHFRSLQPIYMSLAGWTCRDDCKYECMWITVGLYLQEGHRVPQFHGKWPFSRFLFIQEPASAVASLLNGLASLVMLCRYRASVPASSPMYHTCMAFAWVSLNAWFWSTVFHTRDTDLTEKMDYFCASAVILHSIYLCCVRTVGLQHPSVARAFGATLLLMLLLHTSYLSLVRFDYSYNMMANVAIGLVNLAWWLAWCLRNHRRLPHTRKCVAVVLLLQGLSLLELLDFPPLFWVLDAHAIWHISTIPVHVLFFRFLEDDSLYLLKESEAKFKLD
Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI.
A2V7M9
Q929A9
ADDA_LISIN
ATP-dependent helicase/nuclease AddA
Listeria
MRLNIPTKPEDALWTDDQWKAIQANGNNILVAAAAGSGKTAVLVTRIIEKLINETENLNVDELLIVTFTNVSAAEMKYRIGKSLEEALVQNPESVHLKKQVALLNYASISTLHSFCLEIIRKHYFEADIDPNFRLIEPIESSMIRDEVLEDLLEKEYSIENNEGFFHLVESFTGDRSDAELHTLISKLYDFSRANPNPDLWLEQMVSFYDTQAITSITELPYFPIIKEDIQLRINQAKSYLLTAIDYANENNGPAPYLSTLENDLAQINTLSSISWDNWQDVKFGFESIDFKRIPALKNKADFDEEYVEEAKKFRDAAKKEVKNVLIDWFSREEENYLSDLEKMKPDIKTLSELVKKFAENFFEEKQQRGVLDFNDLEHLALKILLKNGAPSDVANSYKKQFKEVLIDEYQDTNMVQETILLLVTNSNDTKGNLFMVGDVKQSIYRFRLAEPTLFMAKYQEYQQDGEGSGIRIDLSQNFRSRKEVLDATNFIFHQLMDKHIAEIDYDEAAELTLGASFPEANNMATELLLIDMKSEEKESEDELSPQELQKNQVESRAIATKIREMIDNKFPIYDKKLQQNRPIQYRDIVILARAMTSAPDMEEAMKIKDIPFYANNNSGYFETTEVATMIALMKVIDNPYQDISLAAVLRSPIIGLNEEELGQIRMAKKKGYFFDAMLAYKDITVSDAANKISRFITQLNNWRELSIRENLTALIWQIYQETNFYEFVGGLPGGKQRQANLRALYDRANQYEKTSFRGLFRFVRFVERLEVRGDDLGTAKTLGEKEDVVRMMTIHASKGLEFPVVIVSGLSRKFNMRDIYSKTLLDKDYGFASNYRDIEKMIVYPTIMQQAIKQKKYREMIAEEMRVLYVALTRAEEKLILTATVPDFEKTSKNWLQVSNQQETILPAAIRAKAKCYLDWIGNATIRHSHFKELLCEEKIKTLPTDMKLQVEIKTKEMFLTDDLEKEKSDNWMENVKAHKQVPVKSPYKDEIERFMHYQYKDEEATGIRAKQSVTELKRQFSLQDSWSDTSILKEFQKVSLDRPKFLQQNKLSATEIGTAMHTLMQAVPLDDKPTEKDLVSLLQLMREKDILTEAQIKAINVNQIIAFFESALGKTVLQKKDKVKREVPFSYLLPAAKLYNQTNLDEHVLIQGVVDSMIEEEDSIILIDYKTDKIEGRYDNWEAAEKVMKERYQIQIKLYAEAIQAISRKKVSHAYLYFFDGQHICQINIEEGI
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation; this subunit has the helicase and 3' -> 5' nuclease activities.
Q929A9
Q11QA3
RL10_CYTH3
50S ribosomal protein L10
Cytophaga
MTKEEKAIIIQEVAQKIAGAATFYITDGSGMTVDQVNKFRKLCFSKGVEYKVVKNSLIKKALQQLNIDHTALNGAALKGASGLMFSDTANVPAKLLKQFHKGGVAKPEFKGASVFADFYVGKDKLDALASIKSKEELIGDIIALLQAPAQRVIGGLTNESRVFAEQA
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Q11QA3
P60152
PSBL_PSINU
Photosystem II reaction center protein L
Psilotum
MTQPNPNKQSVELNRTSLYWGLLLIFVLAVLFSNYFFN
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
P60152
Q9AXI1
OL141_ARAHY
Oleosin 5 variant A
Arachis
MATATDRAPHQVQVHTPTTQRVDVPRRGYDVSGGGIKTLLPERGPSTSQIIAVLVGVPTGGTLLLLSGLSLLGTIIGLAIATPVFTFFSPVIVPAVVTIGLAVTGILTAGACGLTGLMSLSWMINFIRQVHGTTVPDQLDSVKRRMADMADYVGQKTKDAGQQIQTKAQDVKRSSS
May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth.
Q9AXI1
Q9GMC8
CP17A_FELCA
Steroid 17-alpha-monooxygenase
Felis
MWELLVFLLFAVAYFLWPKAKCPGAKYPKSLPSLPLVGSLLFLPRSGHPHKNFFKLQKKYGPIYSFRLGTKTTVMVGDHQLAKEVLVKKGKEFSGRPHVVTLDILSDNQKGIAFADHGASWQMHRKLALATFALFKDGDQRLEKIICREISLLCDNLAMQDGQSIDLYLPLFLAVTNIICLICFNSSFKNGDPALKIIQNYNEGILKTLGKDNLVDIFPVLKIFPNKTLEKMKNYVKNRDELLREILEKHKENFSNDSITNMLDVLIQARMNSDNNGAASDQDSKLLSDKHILTTIGDIFGAGVETTTSVVRWTVAFLLHHPQLYKKLQEEIDQNIGFSRTPTMSDRNQLILLEATIREVLRIRPVAPTLIPHKAIMDSSIGEFAVDKGTNVIINLWALHHNEKEWYRPDQFMPERFLDPTRSQLISPSLSYLPFGAGPRSCLGESLARQEVFLFMAWLLQRFDLEVPDDGQLPHLEGNPTVVFLIAPFKVKVKVRQAWREAQAEGST
A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Q9GMC8
A5F1A0
CHED_VIBC3
Probable chemoreceptor glutamine deamidase CheD
Vibrio
MLVVAVRFSIIWDILFMSDSKLATKRKLKQEEAKGQYYRFNHPSDHRHWVKVMPGGVYATSDQEIIHTGLGSCVSACAWDIEMKVGGMNHFLLPFNNQFESQHWHPQALLSDSSRYGCYAMEVLINRLLSMGAERERLKFKLFGGAHLMGYQSLVGEKNVEFVLEYAKREKLNVVAQDLGGAQPRKLLFDPQAGQAWVKRIGFSSAHAIKQDEELYQHSIDKQIPSDDVELFQ
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
A5F1A0
Q6C0Z6
CCPR_YARLI
Cytochrome c peroxidase, mitochondrial
Yarrowia
MRSFRAVRNFSTTAKRLSQAPKASTPNASSGNGFVLAFVAAAAGAGAYYYYANSPAAKVETFNATKADYQKVYDAIADKLIEDDDYDDGSYGPVLLRLAWHSSGTYNKSDNKFGSSGGTMRFKPEASHAANNGLVNARNFLKPIHEKFPWISTGDLYTLGGVTAVQELGGPIIPWKRGRVDEPESASPPDGSLPDASQGATHVRNVFNRQGFNDQEMVALIGAHALGRCHKQNSGFEGPWTFSPTMFTNDFYKLLLDDKWQWKKWDGNPQYEDVKTKSLMMLPTDMALATDKNFKKWATAYAKDQDLFFKDFSAAFSKMLNNGVDFPQGTEIWEFKPKNA
Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
Q6C0Z6
Q1G9W7
RECO_LACDA
Recombination protein O
Lactobacillus
MAADLLDVHGLLFKRQQYKEADLLAKLWTKELGIVTVIAKGGMRPKSQLAAAVLPFTEGTFGILTRYKGISQLRTYKKLSQHDELFTDLDKNAYLSYLFDLADHAFSEYQKLGGYYDLLLVAFNRIVAGQDPEIIAQIVQLQLLDAFGVAPQLGACVICGKEKGIFDYSIAAGGVVCSDHFRSVSRLHLSPKATALIRTLALLPISRLGEIQIGEDLKKESRRAIAQIYQATVDLHLPSLRFLNEVRGS
Involved in DNA repair and RecF pathway recombination.
Q1G9W7
A5V6A9
DXS_RHIWR
1-deoxyxylulose-5-phosphate synthase
Rhizorhabdus
MNDRPPTPLLDTVSTPEDLRRLKPADLRQLADELRAEMISAVSVTGGHLGAGLGVVELTVALHYVFDTPRDVLIWDVGHQAYPHKILTGRRDRIRTLRQGGGLSGFTKRSESEYDPFGAAHSSTSISAALGFAVANKLANKEGRAIAVIGDGAMSAGMAYEAMNNAKQAGNRLIVILNDNDMSIAPPVGALSAYLAKIVSSRPFLSMRGFAKRVAQKLPRPIHDFAKRSEEYARGMATGGTLFEELGFYYVGPVDGHNLDHLLPILENVRDGDHGPILIHVVTNKGKGYAPAEAAADKYHGVQKFDVVSGVQAKAPPGPPSYTGVFADALVAEAKRDDRICAITAAMPSGTGLDKFGKAFPERSFDVGIAEQHAVTFAAGLAAQGYRPFCAIYSTFLQRAYDQVVHDVAIQNLPVRFAIDRAGLVGADGSTHAGSFDITYLATLPNMVVMAAADEAELVHMVHTAAVHDSGPIALRYPRGNGVGVALPAAPERLAIGKGRIVREGKTVALLSLGTRLGEALRAADQLDALGLSTTVADLRFAKPLDEAMIQTLLTSHEVAVTIEEGAIGGLGAHVLTLASDLGLIDGGLKLRTMRLPDAFQEHDKPEKQYAEAGLDAESIVATVLAALHRNSKGLEESA
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
A5V6A9
G0KYB1
TRI3_TRIAR
Trichothecene biosynthesis cluster protein 3
Trichoderma
MGSKLPELPKLSPEKHRWEKSNVDPRVLQRRGIGSEAIVGMERSNRRGQYDLYLLATLRTAHVSTSTPLSLLYLKEKLELALLVMRFEHPECACTVTWDDQVPPIIQYASPQNDEEALMWAKSSVHIRTTSQTGFDVRYEIEGKRQDLDQDNMEPSRPIVIYLISNVTNGDAQLTSGATVDVLLHMNHLFWDGISARMFTGDLFRELNKLINSNEQELPKLQWGTEASNLSAPVLDALKINIEELREEFEAASNQFVKALYENYGGWGLEFKSGLGLPRTDIHTSTATESKAIINGVKTRLGPQYTISHLAQAAVVIAMLEIIQPPNLTDKDIFVSPMPVNGRRWLKDGLADHHYSICETGAVIRIENIKSLVLNNNNDKGYRPRCDEKKPGEDVKKSFDQWLGNPYQLALGLAVHTLEASFLTANPMPFDKVAAPFFISDGRNEQFIPASITTTTGEILMTIDNFVFFLNQCLPYLAIRLESWKDASTLSVCYNKANYSQEEATKFLKCVAKYMLIFSQ
Trichothecene O-acetyltransferase; part of the gene cluster that mediates the production of the antimicrobial trichothecene harzianum A (HA) that plays a role in Botrytis cinerea antagonistic activity and plant defense priming . The biosynthesis of harzianum A begins with the cyclization of farnesyl diphosphate to trichodiene and is catalyzed by the trichodiene synthase TRI5 . Trichodiene undergoes a series of oxygenations catalyzed by the cytochrome P450 monooxygenase TRI4. TRI4 controls the addition of 3 oxygens at C-2, C-11, and the C-12, C-13-epoxide to form the intermediate isotrichodiol . Isotrichodiol then undergoes a non-enzymatic isomerization and cyclization to form 12,13-epoxytrichothec-9-ene (EPT) which is further converted to trichodermol by the cytochrome P450 monooxygenase TRI11 via C-4 hydroxylation . The last step of HA synthesis is esterification of an octatriendioyl moiety to the C-4 oxygen of trichodermol. The octatriendioyl moiety is probably produced by the polyketide synthase TRI17 and the esterification performed by the trichothecene O-acetyltransferase TRI3 (Probable).
G0KYB1
P32090
MUTT_PROVU
dGTP pyrophosphohydrolase
Proteus
MMDKKKLHIAAGVICDKHNNVFIAQRPLKSHMGGFWEFPGGKLEDNETPEQALLRELQEEIGIDVTQCTLLDTVAHDFPDRHITLSFFLVTEWKNELTEKKGSCRVGHLLCL
Specifically hydrolyzes both 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) to the related monophosphates, thereby cleaning up the nucleotide pools and preventing misincorporation of 8-oxoGua into DNA and RNA. It prevents replicational errors by removing an oxidatively damaged form of guanine (8-oxo-dGTP) from DNA and the nucleotide pool. 8-oxo-dGTP can be inserted opposite dA and dC residues of template DNA with almost equal efficiency thus leading to A.T to G.C transversions.
P32090
Q83SN2
SECA_SHIFL
Protein translocase subunit SecA
Shigella
MLIKLLTKVFGSRNDRTLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVLENLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGLTVGINLPGMPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKRVNKIIPHLIRQEKEDSETFQGEGHFSVDEKSRQVNLTERGLVLIEELLVKEGIMDEGESLYSPANIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDLPDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLNAKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKADWQVRHDAVLEAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYSQRNELLDVSDVSETINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLDLPITEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEELEQQRRMEAERLAQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCPCGSGKKYKQCHGRLQ
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Q83SN2
A0LIJ7
RL16_SYNFM
50S ribosomal protein L16
Syntrophobacter
MLAPKRVKFRKQQKGRMRGTAFRGSTLSFGDFGLKALECGYITSRQIEAARIAITRHVKRGGKVWIRFFPDKPFTKKPAETRMGKGKGSPEGWHAVIKPGRVLYEIKGVPETIAREALNLAAHKLPIPTRFVSRQDVL
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
A0LIJ7
A8ANW0
ISPF_CITK8
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Citrobacter
MRIGHGFDVHAFGGEGPIIIGGVRIPYDKGLLAHSDGDVALHALTDALLGAAALGDIGKLFPDTDPAFKGADSRELLREAWRRIQAKGYTLGNVDVTIIAQAPKMLPHIPQMRVFIAEDLGCHMDDVNVKATTTEKLGFTGRGEGIACEAVALLIKAAK
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
A8ANW0
P45378
TNNT3_HUMAN
Fast skeletal muscle troponin T
Homo
MSDEEVEQVEEQYEEEEEAQEEAAEVHEEVHEPEEVQEDTAEEDAEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMELQALIDSHFEARKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILAERRKPLNIDHLGEDKLRDKAKELWETLHQLEIDKFEFGEKLKRQKYDITTLRSRIDQAQKHSKKAGTPAKGKVGGRWK
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
P45378
P00309
PHEA_MASLA
Phycoerythrocyanin alpha chain
Mastigocladus
MKTPLTEAIAAADLRGSYLSNTELQAVFGRFNRARAGLEAARAFANNGKKWAEAAANHVYQKFPYTTQMQGPQYASTPEGKAKCVRDIDHYLRTISYCCVVGGTGPLDDYVVAGLKEFNSALGLSPSWYIAALEFVRDNHGLTGDVAGEANTYINYAINALS
Light-harvesting photosynthetic bile pigment-protein from the phycobiliprotein complex.
P00309
Q15661
TRYB1_HUMAN
Tryptase alpha-1
Homo
MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates .
Q15661
Q3BUQ7
SYA_XANC5
Alanyl-tRNA synthetase
Xanthomonas
MNAPAKFSTSQIRSDFLAFFEGKGHTIVPSAPLVPGNDPTLLFTNSGMVQFKDVFLGAEKRSYVRAADVQRCLRAGGKHNDLDSVGYTARHHTFFEMLGNWSFGDYFKKDAIAWAWELLTQVWKLPADRLLVTVYHTDEEAFALWRDMIGIPESRIVRIGDNKGAPYASDNFWQMADTGPCGPCTEIFFDHGDHIAGGPPGSPDEDGDRFIEIWNLVFMQFDRQPDGTLVPLPAPCVDTGMGLERLAAILQHVHTNYEIDLFQALIGKASALTGITDLENKSLRVIADHIRACSFLIVDGVLPSNEGRGYVLRRIIRRALRHGWMLGVRQPFFSKMVPTLVELMGEAYPELVVAQDTVARALLAEEERFAETLDAGMKIFDEVASRSQDIIPGADAFRLYDTYGFPVDLTADIARERGMRVDMEGFEFAMERQRETARAAGKFGGGVALPADLVASMSPTVFLGYEAYDADALKVVALLKQGRPVERAEAGDEVIVFTDRTPFYAESGGQVGDSGQLSGPGVSINVTDTQKFAGQFHGHVGRISEGALALGDVLAGGIDTQRRGKTILNHSATHLLHAALREVLGTHVQQKGSLVAPDRLRFDFSHFQPFTADELAVIERKVNAEVRANHGVEVHNMAMQEALDFGAMALFGEKYGENVRVLKMGGYSTELCGGTHVTRTGDIGLFKITSEGGVSSGVRRIEAVTGQGALDYVADEERRLLEAANLLGGNTSEVVDKVRALTERQKRLERELESLKAKLASGATADLGASAIDVVGVKVVAVRLEGFDAKALRDAMDRLKQQLGDSVIVLAGASGGKVALVAGVNGSPTGKVKAGELLGHIASQIGGKGGGRPDLAQGGGEDGPALATALDGVPLWVKQHLG
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Q3BUQ7
C5CIV6
ATPA_KOSOT
F-ATPase subunit alpha
Kosmotoga
MKISPSEITKIIEEQLKRSDREIDYFEAGRIIQVGDGIARAYGLKGVMSNELVQFENGEYGLALNLEEDNVGIVVLGDYREIKEGDLVKRTGRIIEVPAGEALLGRVVNPLGIPLDGKGPIEASEHRPVEIKAPGVVMRKPVDTPLQTGIKAIDAMIPIGRGQRELIIGDRQTGKTAIAIDTIINQKDQGVYCIYVAIGQKTAVLARIIDKLEETGAMEYTTIVAATANDPATLAYLAPYAGAAMGEYFMYSGKDALVIYDDLSKHAAAYRELSLLLRRPPGREAYPGDVFYLHSRLLERAARLNEEHGGGSLTALPIIETLANDVSAYIPTNVISITDGQIYLDPNLFYAGNRPAINVGLSVSRVGGSAQIKAMKKIAGSLRLDLAQYRELLAFAQFSTELDKATQAQLIRGEKLTELLKQEQYSPMPVEEQIAVLYAGTRGYLDDLPTDKIRQFEKQLLQTMRQKYADVLKAIREKKDMTEEIEAGLKKAVEDVRQAFVS
Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.
C5CIV6
Q9C6B9
PEAM3_ARATH
Phosphoethanolamine N-methyltransferase 3
Arabidopsis
MASYGEEREIQKNYWKEHSVGLSVEAMMLDSKASDLDKEERPEILAFLPPIEGTTVLEFGAGIGRFTTELAQKAGQVIAVDFIESVIKKNENINGHYKNVKFLCADVTSPNMNFPNESMDLIFSNWLLMYLSDQEVEDLAKKMLQWTKVGGYIFFRESCFHQSGDNKRKYNPTHYREPKFYTKLFKECHMNDEDGNSYELSLVSCKCIGAYVRNKKNQNQICWLWQKVSSDNDRGFQRFLDNVQYKSSGILRYERVFGEGFVSTGGLETTKEFVDMLDLKPGQKVLDVGCGIGGGDFYMAENFDVDVVGIDLSVNMISFALEHAIGLKCSVEFEVADCTKKEYPDNTFDVIYSRDTILHIQDKPALFRRFYKWLKPGGKVLITDYCRSPKTPSPDFAIYIKKRGYDLHDVQAYGQMLRDAGFEEVIAEDRTDQFMKVLKRELDAVEKEKEEFISDFSKEDYEDIIGGWKSKLLRSSSGEQKWGLFIAKRN
Catalyzes N-methylation of phosphoethanolamine, phosphomonomethylethanolamine and phosphodimethylethanolamine, the three methylation steps required to convert phosphoethanolamine to phosphocholine.
Q9C6B9
Q9NZP0
OR6C3_HUMAN
HSA8
Homo
MNHTMVTEFVLLGLSDDPDLQIVIFLFLFITYILSVTGNLTIITLTFVDSHLQTPMYFFLRNFSFLEISFTTVCIPRFLGAIITRNKTISYNNCAAQLFFFIFMGVTEFYILTAMSYDRYVAICKPLHYTSIMNRKLCTLLVLCAWLSGFLTIFPPLMLLLQLDYCASNVIDHFACDYFPLLQLSCSDTWLLEVIGFYFALVTLLFTLALVILSYMYIIRTILRIPSASQRKKAFSTCSSHMIVISISYGSCIFMYANPSAKEKASLTKGIAILNTSVAPMLNPFIYTLRNQQVKQAFKNVVHKVVFYANQ
Odorant receptor.
Q9NZP0
P0AES2
GUDD_ECOLI
D-glucarate dehydratase
Escherichia
MSSQFTTPVVTEMQVIPVAGHDSMLMNLSGAHAPFFTRNIVIIKDNSGHTGVGEIPGGEKIRKTLEDAIPLVVGKTLGEYKNVLTLVRNTFADRDAGGRGLQTFDLRTTIHVVTGIEAAMLDLLGQHLGVNVASLLGDGQQRSEVEMLGYLFFVGNRKATPLPYQSQPDDSCDWYRLRHEEAMTPDAVVRLAEAAYEKYGFNDFKLKGGVLAGEEEAESIVALAQRFPQARITLDPNGAWSLNEAIKIGKYLKGSLAYAEDPCGAEQGFSGREVMAEFRRATGLPTATNMIATDWRQMGHTLSLQSVDIPLADPHFWTMQGSVRVAQMCHEFGLTWGSHSNNHFDISLAMFTHVAAAAPGKITAIDTHWIWQEGNQRLTKEPFEIKGGLVQVPEKPGLGVEIDMDQVMKAHELYQKHGLGARDDAMGMQYLIPGWTFDNKRPCMVR
Catalyzes the dehydration of glucarate or L-idarate to 5-keto-4-deoxy-D-glucarate (5-kdGluc) . Also catalyzes the epimerization of D-glucarate and L-idarate .
P0AES2
F6M8H7
SMST_SANMU
Probable sesquiterpene synthase
Santalum
MENQKMPISSVPNLKDLNMISRPIANFPPSIWGDRFINYTCEDENDQTQKERQVEELKEQVRRELAATVDKPLQQLNIIDATQRLGIAYLFENEIEESLKHIYLHTYVENNCFEGSDDLYSVALWFRLLRQNGYKVSCDVFNKFRDNEGNFKNNLMEDAKGLLELYEATHVSIHGEEMLDDALEFTKTRLESVVSHLNYPLAEQVRHALYQPLHRGLPRLEAVYFFRIYEAHASHNKALLKLAKLDFNLLQSFHKKELSDIARWWKSLDFAAKFPFARDRLVEGYFWVLGVYFEPQYSLARKIIIKVFTMISTIDDIYDAYGTLDELKLFTKAMQRWDVGSLDQLPEYMKPCYKSILDVYNEIEEEMANQGSLFRMHYAKEVMKTIVEGYMDEAKWCHEKYVPTFQEYMSVALVTSGYTFLTTISYLGMGEIASKEAFDWLFSHPPVIEASESVGRLMDDMRSHKFEQERGHVASGIECYMKQYGVTEEEAHDEFRKRLVKAWKDINEECLRPYRVPKPLLTRILNLTRVIDVIYKNEDGYTHVKKAMKDNIASLLIDPVIV
Sesquiterpene synthase.
F6M8H7
Q9LYC8
GRXS6_ARATH
Protein ROXY 17
Arabidopsis
MESVRSLVEDKPVVIFSKSSCCMSHSIQTLISGFGAKMTVYELDQFSNGQEIEKALVQMGCKPSVPAVFIGQQFIGGANQVMTLQVKNQLAAMLRRAGAIWV
May only reduce GSH-thiol disulfides, but not protein disulfides.
Q9LYC8
Q51834
RNZ_PORGI
tRNase Z
Porphyromonas
MAAFSVHILGCGSALPTTHHHPSSQVIDLRDKLYMIDCGEGVQRQFRHEKLHFGRLIHIFISHLHGDHCFGLPGFISTLGLLGRTGTLHVHGPEGIERFLSPILEQFCHRMPYQVEIHTIDASRHALVHEDKSVKVYSIPLSHRIPAVGYLFEEKCRARHLNKAAAEFYNIPLAEYPLIIEGSDYTTPDGRIIPNRHLTTPGTPPRRYAYCSDTEFCPSIVPIIQGVDLLYHEATFMEEDRARAKETFHSTAKEAAEIARQAGAKRLLIGHYSGRYKDVQGLLEEAQSVFKPTIAANERMRIDL
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
Q51834
A8YTF6
Y401_LACH4
Nucleoid-associated protein lhv_0401
Lactobacillus
MSRRPNFGGMGMGGMNMQQMMKQAKKLQAQMAQEQENITAQEFTGKSADDLVVATFTGDRKLKDIKIDKEAIDPDDPDMLQDLVIDAVNKGLSQIDEATQASLGKYTKGLM
Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.
A8YTF6
B8NM79
USTS_ASPFN
Ustiloxin B biosynthesis protein S
Aspergillus subgen. Circumdati
MTKTEESPLHFFDIFSTLPGTSKSWSSNVLKIRMVLNYKGIPYTQSFHSYPDIAPLLQSLSVPPHKQGRFKYTLPAICHPSSVKSSPSGAMMDSLPIACHLDETYPDPPLFPSGEASYALALAIGKLMVPAALKTCDLLLPKAEEVLDDRGKEYFVRTRTEIFGKPLSELRPKTEEGVRAIVDGMKADMEVFISMLRGRGEGKKSGPFLEGEKPGYADFILVTFLSWSHRFDMELWREIMDMGNGEFRALWHASVQWLEGQGEEKEWAVPQLSTVD
Glutathione S-transferase-like protein; part of the gene cluster that mediates the biosynthesis of the secondary metabolite ustiloxin B, an antimitotic tetrapeptide . First, ustA is processed by the subtilisin-like endoprotease Kex2 that is outside the ustiloxin B gene cluster, at the C-terminal side of Arg-Lys, after transfer to Golgi apparatus through the endoplasmic reticulum (ER) . Cleavage by KEX2 generates 16 peptides YAIG-I to YAIG-XVI . To process the precursor peptide further, at least two peptidases are necessary to cleave the N-terminal and C-terminal sides of the Tyr-Ala-Ile-Gly core peptide which serves as backbone for the synthesis of ustiloxin B, through cyclization and modification of the tyrosine with a non-protein coding amino acid, norvaline . One of the two peptidases must be the serine peptidase ustP; and the other pepdidase is probably ustH . Macrocyclization of the core peptide derived from ustA requires the tyrosinase ustQ, as well as the homologous oxidases ustYa and ustYb, and leads to the production of the first cyclization product N-desmethylustiloxin F . For the formation of N-desmethylustiloxin F, three oxidation steps are required, hydroxylation at the benzylic position, hydroxylation at either the aromatic ring of Tyr or beta-position of Ile, and oxidative cyclization . UstQ may catalyze the oxidation of a phenol moiety, whereas the ustYa and ustYb are most likely responsible for the remaining two-step oxidations . N-desmethylustiloxin F is then methylated by ustM to yield ustiloxin F which in turn substrate of the cytochrome P450 monooxygenase ustC which catalyzes the formation of S-deoxyustiloxin H . The flavoprotein monooxygenases ustF1 and ustF2 then participate in the modification of the side chain of S-deoxyustiloxin H, leading to the synthesis of an oxime intermediate, via ustiloxin H . Finally, carboxylative dehydration performed by the cysteine desulfurase-like protein ustD yields ustiloxin B .
B8NM79
P07306
ASGR1_HUMAN
Hepatic lectin H1
Homo
MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL
Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.
P07306
O31678
QUEF_BACSU
PreQ(0) reductase
Bacillus
MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYFVKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMNIIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPETIDNR
Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1), a late step in the queuosine pathway.
O31678
O60512
B4GT3_HUMAN
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
Homo
MLRRLLERPCTLALLVGSQLAVMMYLSLGGFRSLSALFGRDQGPTFDYSHPRDVYSNLSHLPGAPGGPPAPQGLPYCPERSPLLVGPVSVSFSPVPSLAEIVERNPRVEPGGRYRPAGCEPRSRTAIIVPHRAREHHLRLLLYHLHPFLQRQQLAYGIYVIHQAGNGTFNRAKLLNVGVREALRDEEWDCLFLHDVDLLPENDHNLYVCDPRGPRHVAVAMNKFGYSLPYPQYFGGVSALTPDQYLKMNGFPNEYWGWGGEDDDIATRVRLAGMKISRPPTSVGHYKMVKHRGDKGNEENPHRFDLLVRTQNSWTQDGMNSLTYQLLARELGPLYTNITADIGTDPRGPRAPSGPRYPPGSSQAFRQEMLQRRPPARPGPLSTANHTALRGSH
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids.
O60512
Q1C2C4
FADB_YERPA
3-hydroxyacyl-CoA dehydrogenase
Yersinia
MLYQSETLQLHWLENGIAELVFDAPGSVNKLDTKTVANLGEALNVLEKQSELKGLLLRSAKTALIVGADITEFLSLFNAPPEKLHQWLVFANTIFNRLEDLPVPTISAINGYALGGGCECILATDFRIASPEARIGLPETKLGIMPGFGGSVRLPRLLGADSALEIIATGKDVTANDALKIGLVDAVVDPEKLVGSALTMLKQAIDGKLDWQAARRPKLEPLKLNPTEAAMCFTIAKGRVMQVAGKHYPAPLTAVKTIEAAAKFGRTEALNLETNSFVPLAGSNEARALVGIFLNDQYVKAQAKKLSKGVAAPKLAAVLGAGIMGGGIAYQSALKSVPVIMKDINENSLDLGMNEAAKLLNKQLERGKVDGLKMASILATIRPTLDYAGIERAQVIVEAVVENPKVKAAVLAEVEALIGEDTVLASNTSTIPIDQLAKSLKRPENFCGMHFFNPVHRMPLVEIIRGAKTSDKTLAAVVAYATQMGKTPIVVNDCPGFFVNRVLFPYLAGFGMLVRDGGDFHQIDKVMEKQFGWPMGPAYLLDVVGIDTAHHAQAVMAAGFPERMNKDYRDAVDVMFDNQRFGQKNGQGFYRYTQDAKGKPRKENDEQVDKLLAEISQPLQEFSDEDIIARTMIPMINEVVRCLEEGIIASAAEGDMALVYGLGFPPFHGGVFRYLDTLGSANYVEMAQRYAHLGALYHVPAGLRAKAEHNESYYPVAAALLDVSTNQPA
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
Q1C2C4
Q08460
KCMA1_MOUSE
Slowpoke homolog
Mus
MANGGGGGGGSSGGGGGGGGGSGLRMSSNIHANNLSLDASSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEVVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDVTDPKRIKKCGCRRLEDEQPPTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELAKPGKLPLVSVNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQNRKEMVYR
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
Q08460
A0B9M2
UPPP_METTP
Undecaprenyl pyrophosphate phosphatase
Methanothrix
MDALQALVLGALQGITEWLPVSSEGQTMLAMISWLGMRPTDALSCSIFLHTGTMLAVLVRFRSRLLGMLNTESKLMRTVIVATLFTGITGVPLYMLFRDRFTGGEQATLLIGSLLIATGLMLRLRSSSTKDMEEISTKDMVLLGLAQGFSILPGVSRSGTTLTVLLMRGVKQDDALMVSFIISVPAVLGAIALDCLAGSPLSIRSLPGAVMLASSFITGYATMDVLMRFSRNVSFSWFCITMGMITLALTALPEVQ
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP).
A0B9M2
F4JSV3
EDA40_ARATH
RING-type E3 ubiquitin transferase EDA40
Arabidopsis
MMNGLRRTFWSSIHKKKDNNRVDDSLDRQKPTTTSRFGFFSNPSTPRSETRPDSVTCSPTIPCQSWSATAISTPSPSLPASPKLQCDTSGDVTPTRNRSPLSFLSVSSSSSTPSSPKSPASFSLLKSKLCFTKVRILNRNNQVNIFKNNSKLTFLRLCYEQSSISSSKCGICLQSAKAGRGTAIFTAECSHTFHFPCVASRAGDRNLLSDCPVCGASWRETSLLPLSLSSSLHESGSESDSKIRESKNNNKSLRVYNDDEPLISSPISRTGFNTIPESNEDEEEEDNDDGEFKGFYVNTPSPLTTKKMLTDSVTGHVDVKLSSEAAIVAVGRGNETYSVLMKIKSPSLPTARRSPVDLVTVIDVSGGNIEMVKRAMRQVISSLRETDRLSMVSFSSSSKRLTPLRRMTANGRRLARRIVDDISGDGDGMSVNDAVKKAAKVIEDRRQKNLFTTIFVLTDRNRNSAHQAQLAQPDFVTSTRFSHLEIPTHTIWLGACNHALPEDVFAKRIKSLLSLSVQDLTLNLGLVSGSGQGKVTSVYSLSGRPVWLGSGLIRLGDMYGDEEREVLVELKSPSSSRSQRIMTVRSRHVDPTTQEIKNYEDRALMIPRPTTVRSSDPSIARLRNLHVSTRAVAESRRLVEVNDYSGAERMLTSARALLVQYGLSSSDSCLRGLEAELADLNRLRGRHVAVKSPEPVVQKSEPLTPTSAWRAAERLAKVAIMRKHMNRVSDLHGFENARF
Probable E3 ubiquitin-protein ligase involved in female gametophyte development. Required for fusion of polar nuclei in the embryo sac.
F4JSV3
B8E8D7
SELO_SHEB2
Protein adenylyltransferase SelO
Shewanella
MKFKQDFFTQLPEFYSQVYPQGITKPEWLAWSDDAAQLIGLSQPTDELLLGLSGNAAVDGATYYAQVYSGHQFGGYTPRLGDGRSIILGEAIGPNGAWDVALKGGGPTPYSRRGDGRAVMRSAVREFLVSEALHHLHVPTTRALAVIGSDLPVWRESQETAAITVRLARSHIRFGHFEFFCHSERGRADKLIQLLNFTITQHYPHLSCDAAGYKAWFLQVVQDTAKMIAHWQAVGFAHGVMNTDNMSILGDSFDFGPFAFLDTFQEDFICNHSDPEGRYAFGQQPGVGLWNLQRLAQALTPVIPSDDLIAILNQYQEALVQPYLRLMRAKLGLSAVDVPSVEQDKQDLDLIGRFTVLMEKNQLDYTQTWRQLGKLDPTSKHSALRDDFIDVSQFDTWYQAYQQRLGAVADIPAWQTERNSVNPKYILRNYLAQEAIIAVEEGNLAPLHLLQKILTQPFAEHAEHEDLAKRPPDWGQGLIMSCSS
Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation).
B8E8D7
Q2NHD1
RADB_METST
DNA repair and recombination protein RadB
Methanosphaera
MKTLSDISESVLIPTNSSLDKLLGGGIEKGCITQFYGPPGSGKTNIALKILYEATKNGSKAIYMDTEGGLSLERIQQIAGTDFGSISKNIYILEPKSFDEQILDIQNIEDILKKDKSIDMLIIDSIVALYRVEDGDPSEINKRLGRLMAKLLRLSREYNVAIVITNQIYSPFDSDDLIIEPIGGTVLKYWSKIIIEIEKSVDSLKRTATLQRHKTKAPGQSIKFEIIDRGII
Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.
Q2NHD1
O67502
TRPA_AQUAE
Tryptophan synthase alpha chain
Aquifex
MGRISDKFTELKEKREKALVSYLMVGYPDYETSLKAFKEVLKNGTDILEIGFPFSDPVADGPTIQVAHEVALKNGIRFEDVLELSETLRKEFPDIPFLLMTYYNPIFRIGLEKFCRLSREKGIDGFIVPDLPPEEAEELKAVMKKYVLSFVPLGAPTSTRKRIKLICEAADEMTYFVSVTGTTGAREKLPYERIKKKVEEYRELCDKPVVVGFGVSKKEHAREIGSFADGVVVGSALVKLAGQKKIEDLGNLVKELKEGLRE
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
O67502
Q2NCP2
NHAA2_ERYLH
Sodium/proton antiporter NhaA 2
Erythrobacter
MFYTAATALRDFLKQESAGGIVLMFAAVLALIFANTALADTYFSVLATEIAVTVGGGGIEKPALLWINDGLMAVFFFLVGLEVKREVLTGQLSSWKQASLPLIAAFGGIVLPALVFYGINSGTPENLSGWAIPAATDIAFALGILALLGKRVPVALKALLLAIAVIDDIAAIAIIAIFYTPGVELAMLGAAAITLLILSAFGRAKAGSSIPYIVLGIVLWYFVLKSGVHATLAGVALAMTVPLIDRKGNHMLEHMEHALHSWVAFLVVPIFALANAGVSFEGVELSALFAPLPLGIALGLIVGKQVGIFGFAWLAVKTGFAQLPSSVGWLQVWGLSLVAGIGFTMSLFIGNLAFADPAQINAVKIGVLSGSLIAALVGIAILVLGAKAPAAKSADERVQAPA
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.
Q2NCP2
Q9D1I2
CAR19_MOUSE
Bcl10-interacting CARD protein
Mus
MTDQTYCDRLVQDTPFLTGQGRLSEQQVDRIILQLNRYYPQILTNKEAEKFRNPKASLRVRLCDLLSHLQQRGERHCQEFYRALYIHAQPLHSHLPSRYSPQNSDCRELDWGIESRELSDRGPMSFLAGLGLAAGLALLLYCCPPDPKVLPGTRRVLAFSPVIIDRHVSRYLLAFLADDLGGL
Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B.
Q9D1I2
Q9QZY7
CD1C2_CAVPO
T-cell surface glycoprotein CD1c2
Cavia
MLFLQFLFVDVVLGGSITENVVQENISLYLMQISSYANQSWTQNLGSAWLDQLQTHSWDSESGTIIFLHAWSRGNFSNEEVTDMQLLLRVHFAELTLDVHQQASQLQFKYPFDIQVRLGCELHSRETTKSFLHVAFNGLNFLSFQHKSCVPSPEGETRAQKACDILNTYEATKEIAYYVMNDICPRLLLSLLEAGKMDLQRQVRPEVWLSSSPNLEPGRLLLACHVSGFYPKPIWVMWMRGAQEQLETKQGDILPHADGTWYLRVTLNVVAEEAAGLSCRVRHSSLRDQDIILYWGHGLSVILIALAVIVPLVLLIVLVLLCKKRCTYQGIP
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Q9QZY7
A7MKE8
NUDL_CROS8
Uncharacterized Nudix hydrolase NudL
Cronobacter
MENSPLTLDRFLSRFQLLRPQMSRSSLNQRQAAVLVPVVRRPEPGLLLTKRAATLRKHAGQVAFPGGAVDDTDASLIAAALREAQEEVAIPPEAVDVIGVLPPVDSVTGFQVTPVVGIIPPDLPYHASEDEVAAVFEMPLAEALRLGRYHPLDIHRRGNHHRVWLSWYQHYFVWGMTAGIIRELALQIGEKP
Probably mediates the hydrolysis of some nucleoside diphosphate derivatives.
A7MKE8
Q886V0
TRMD_PSESM
tRNA [GM37] methyltransferase
Pseudomonas
MASLRIEVISLFPEMFSAISEYGITSRAVKQGLLQLTCWNPRDYTTDRHHTVDDRPFGGGPGMVMKIKPLEDALVQARQAAGDAAKVIYLSPQGRQLNQAAVRELAQEEAIILIAGRYEGIDERFIEAHVDEEWSIGDYVLSGGELPAMVLIDAVTRLLPGALGHVDSAEEDSFTDGLLDCPHYTRPEVYADQRVPDVLLSGNHAHIRRWRLQQSLGRTYERRADLLESRSLSGEEKKLLAEYIRERDDS
Specifically methylates guanosine-37 in various tRNAs.
Q886V0
Q6YQX2
PNP_ONYPE
Polynucleotide phosphorylase
Candidatus Phytoplasma asteris
MLKKVFETTNLKDSFQVEIGTYARNVDASILVRYQDTVVLTTTVFSRKPNNLDFLPLTVIYQEKLYAAGKIPGSFLRREGRSNDHEILTSRLIDRSLRPLFPDYFQQEVQVINTVLSLDPDFKSELASMLGSSLSLLISEIPFFEAISGVYVGKINDKFIINPTLQQLANSTLHLMVAGTKHNVTMIEAHANEVSEQDFLEAINFAHQYIKKLCLFQENIKQQFAPAKITNTLHQTEQTQQQAFFAKHQSQVKQAILSCNSKNDLQQLKEQILDQAKQTPFFKTIDTATVFDYEAHKKHLQTTETLFQKLSKQETRSLILQEKIRPDKRGLEEIRTLESQIDLLPRAHGSALFTRGQTQSLAAVTLGCLSESKIIDGLSDEQNKRFMLHYNFPPFSVGAVGRYTAPSRREIGHGTLAEKAISQVLPEEKDFPYTIRVVSEILESNGSSSQATVCASSLALMASGVPLKKAVAGMSVGLVFDQATNKYVILSDIQGLEDHVGDMDLKIAGTNKGITALQMDLKIQGIHFKILQEAFLQAKKGRLHILEHMSQTISQPRLEVSKYAPKVCMMQIKPEKIRDIIGSGGKIINQIIESHDGVKIDIEQDGRVFVMHSNLETVKKTVAFIESLIQEIQIGTCYQASILRFLSDKQGKMIGAVAQVCPGIEGLIHVNQKKFQKITDVLKIGETVSVKCTKINDRGRIDFLLLPKNTQEKNS
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
Q6YQX2
Q601U7
TRUB_MESH2
tRNA-uridine isomerase
Mesomycoplasma
MADTLDLGSSAFGCKGSSPFLRTTMIGQPCVDFFFFFFFFFKKKKKKMITFLYKPKKISSAKFLRQWSKTNLIKKAGHAGTLDPLASGLLLVATEDDTKLLQYLDQKTKTYLAKIQFGFWSTTYDAEGQIYGVEQPIKVTKDNLEQALNRLSESQKQVPPVFSSKKVSGKSAYHYARQGKQIELKPISIKISKTILINFDEKLQNCVIMWQVSRGCYIRSLADDLGKMLKTRAYLSDLERTKIGNFDKKFLNQSLKPQDLFDLQQVKLDLENLELLLQGKKINYFAKNSELNTLIFKDEVVGFGKIINNVLITKKLFGNRIKKIINT
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
Q601U7
Q6AF47
WHIA_LEIXX
Probable cell division protein WhiA
Leifsonia
MALTADVKDELTKVEVSKTTVRAAELATILRFSGGLHLIGGRIAVESELDTPELARRVRKDLAELYGVRGVVSVISTSGVRRASQYLVRVLDGGETLARQTGLLDAHRRPIRGLPNRLTTGSREELAAVWRGAFLASGSLTDPGRSAALEVTCPGNEAAMALVGAAGRIGVAAKAREVRGVHRVVIRDGEAISAMLVQMGAAQTVSNWEELRQRREVRATANRLVNFDDANLRRSAQAAVAACARVERALEILGDDIPEHLQYAGRLRLAHRDASLDELGHYADPPMTKDAVAGRIRRLLAMADKRASDLGVPSTEASLPADFDEV
Involved in cell division and chromosome segregation.
Q6AF47
A7I9I6
IF6_METB6
Translation initiation factor 6
Methanoregula
MERTTTFAGDPNIGVFARVAGNIAVIPPEAPEEFRNAIREGLGVELLVTTIQGSAIIGSLVAGNSRGLVVSGLATDEELAVLKKHRKVMLLCETMNAAGNVIMANDTFAAVHPDLPAEVAEEIGAFLGVEVIHLTLGGVRTTGMAGVATNKGVIVHPRATAQEIARLETVSGIPVGTGTINMGSGLVGTGLLVNDTGYLAGNATSGFELGRVEDVFGFLE
Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex.
A7I9I6
P70981
YBAC_BACSU
Probable aminopeptidase YbaC
Bacillus
MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGTPQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLAHFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISESKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNEYGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQYYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL
Probable aminopeptidase.
P70981
B5F138
LFTR_SALA4
Phenyalanyltransferase
Salmonella
MRLVQLSRHSIAFPSPEGALREPNGLLALGGDLSPARLLMAYQHGIFPWFSPGDPILWWSPDPRAVLWPEKFHLSRSMKRFHNASPYRVTLNYAFDRVIDGCANHRDEGTWITRGIEEAYRRLHELGHAHSIEVWRDRELVGGMYGVSQGALFCGESMFSRQENASKTALLVFCAEFTRHGGKLIDCQVLNSHTASLGAIEIPRRDYLDHLAALRQQPLASRFWVPRTLFLPRK
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
B5F138
Q8FFK3
NUON_ECOL6
NDH-1 subunit N
Escherichia
MTITPQNLIALLPLLIVGLTVVVVMLSIAWRRNHFLNATLSVIGLNAALVSLWFVGQAGAMDVTPLMRVDGFAMLYTGLVLLASLATCTFAYPWLEGYNDNKDEFYLLVLIAALGGILLANANHLASLFLGIELISLPLFGLVGYAFRQKRSLEASIKYTILSAAASSFLLFGMALVYAQSGDLSFVALGKNLGDGMLNEPLLLAGFGLMIVGLGFKLSLVPFHLWTPDVYQGAPAPVSTFLATASKIAIFGVVMRLFLYAPVGDSEAIRVVLAIIAFASIIFGNLMALSQTNIKRLLGYSSISHLGYLLVALIALQTGEMSMEAVGVYLVGYLFSSLGAFGVVSLMSSPYRGPDADSLFSYRGLFWHRPILAAVMTVMMLSLAGIPMTLGFIGKFYVLAVGVQAHLWWLVGAVVVGSAIGLYYYLRVAVSLYLHAPEQPGRDAPSNWQYSAGGIVVLISALLVLVLGVWPQPLISIVRLAMPLM
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
Q8FFK3
B3E2K5
KTHY_TRIL1
dTMP kinase
Trichlorobacter
MFITFEGIEGCGKSTQIALLAASLQQAGQRVLLTREPGGCPIADQIRSVLLDAANTALVPMAELMLYAASRAQHLAEVVSPALAEGVIVLCDRFSDATRAYQSFGRGIDRQVIETLNSLACDGISPDLTVLLDCPVETGLGRARQRIDSTSGPREERFELESLAFHQRVRDGYLQLAAEEPGRFVIVDATVQPAQVASAISDAVLSRLAVPV
Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.
B3E2K5
A1TND9
ORN_ACIAC
Oligoribonuclease
Acidovorax
MSDTAPVSVPPVLPKSDLNFVWLDCEMTGLDPEKDRLLEIAVVVTGPELEPRVEGPVFAIHQSDALLDGMDAWNKGTHGRSGLIEKVRASTVTEAEAEQAILEFLARYVRKGVAPMCGNSIGQDRRFLVRYMPKLEAFFHYRNVDVSTLKELSRRWKPEVYASFKKAQKHTALADVHESIEELAHYRKHLLVP
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
A1TND9
P13564
GLNA2_HORVU
Glutamate--ammonia ligase
Hordeum
MQVRRDDDGAGGCAGDAVPGGGEGQDGVPARQPAGRVWGVSRAARATSGFKVLALGPETTGVIQRMQQLLDMDTTPFTDKIIAEYIWVGGSGIDLRSKSRTISKPVEDPSELPKWNYDGSSTGQAPGEDSEVILYPQAIFKDPFRGGNNILVICDTYTPQGEPIPTNKRHMAAQIFSDPKVTSQVPWFGIEQEYTLMQRDVNWPLGWPVGGYPGPQGPYYCAVGSDKSFGRDISDAHYKACLYAGIEISGTNGEVMPGQWEYQVGPSVGIDAGDHIWASRYILERITEQAGVVLTLDPKPIQGDWNGAGCHTNYSTLSMREDGGFDVIKKAILNLSLRHDLHIAAYGEGNERRLTGLHETASISDFSWGVANRGCSIRVGRDTEAKGKGYLEDRRPASNMDPYTVTALLAETTILWEPTLEAEALAAKKLALKV
The light-modulated chloroplast enzyme, encoded by a nuclear gene and expressed primarily in leaves, is responsible for the reassimilation of the ammonia generated by photorespiration.
P13564
P48210
CH60_BORPE
Chaperonin-60
Bordetella
MAAKQVLFADEARVRIVRGVNVLANAVKTTLGPKGRNVVLERSFGAPTVTKDGVSVAKEIELKDKFENIGAQLVKDVASKTSDNAGDGTTTATVLAQAVVQEGLKYVAAGFNPIDLKRGIDKAVAAAVEELKKLSKPVTTSKEIAQVGSISANSDASIGQIIADAMDKVGKEGVITVEDGKSLENELDVVEGMQFDRGYLSPYFINSPEKQVAALDDPYVLIYDKKVSNIRDLLPVLEQVAKSSRPLLIIAEDVEGEALATLVVNNIRGILKTTAVKAPGFGDRRKAMLEDIAILTGGTVISEETGMSLEKATLQDLGQAKRIEVAKENTTIIDGAGDGKSIEARVKQIRAQIEEATSDYDREKLQERVAKLAGGVAVIRVGAATEVEMKEKKARVEDALHATRAAVEEGVVPGGGVALLRAKQAITGLKGDTADQNAGIKLILRAVEEPLRTIVTNAGDEASVVVNTVLNGKGNYGYNAATGEYGDLVEQGVLDPTKVTRTALQNAASVASLLLTAEAAVVELMENKPAAAPAMPGGMGGMGGMDF
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
P48210
Q5L3R4
RS13_GEOKA
30S ribosomal protein S13
Geobacillus thermoleovorans group
MARIAGVDIPRDKRVVISLTYIYGIGKPTAQKILKEAGVSEDTRVRDLTEEELGRIREIVGRLKVEGDLRREVSLNIKRLMEIGCYRGLRHRRGLPVRGQNTKNNARTRKGPRRTVANKKK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
Q5L3R4
Q136C2
LEXA_RHOPS
LexA repressor
Rhodopseudomonas
MLTRKQFELLKFINERLKEAGVPPSFDEMKDALDLRSKSGIHRLITALEERGFIRRLPNRARAIEVIKLPDLGGNTGGGRRGFTPSVIEGTLGKVRPPSHSHAEDESDRNVAVPVMGRIAAGTPIEALQTRSHTISVPPDMLGSGEHYALEVRGDSMVEAGILDGDMALIQRNESAETGDIVVALIDEEEATLKRFRRRGASIALEPANAAYEVRILPPNRVRIQGKLIGLYRKY
Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.
Q136C2
P57834
LOLB_PASMU
Outer-membrane lipoprotein LolB
Pasteurella
MVMKKQHFLLPIIASFFLFACTLDTERPTDVKYISHTDPTWQQHLSQLKKIRDYTNQGQLGYISQKERFSTRFDWQYQNPTNYRLTLSSTLSPTTLSIEVRHNVMHLSDNKGPLRSAQDAKRLLKEIVGMDLPLDQFALWLKGQPDESREYRVAENHLLAHFSYPIDNQQWTADYLSYHQLPLPLPKDILLKTEGQTLKIRIDNWTY
Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
P57834
A9IMW7
MIAB_BART1
tRNA-i(6)A37 methylthiotransferase
Bartonella
MNKVNPKNTSPVAPKKVFIKTYGCQMNVYDSQRMTDSLSSQGYVTTQTPNDADLILVNTCHIREKAAEKLYSDLGRLRVMRQERTPDKPLTVGVTGCVAQAEGSEILRRAPIVDLVIGPQMYHRLPELLEKAKQGKKIIETDYAVEDKFAHLPPHNKRAVRKRGVSAFLTVQEGCDKFCTFCVVPYTRGAEISRSVEQITEEARQLIEAGVKEITLLGQNVNGWHGQSADGKTWRLGDLLYHLAKLDGLKRLRYTTSHPRDMDDSLIAAHRDLDMLMPYLHLPVQSGSDRILKAMNRQHKSSYYLHLIEKIRAARPDIAFSGDFIVGFPGETDEDFEETIKLIQQVQYSSAYSFKYSPRPGTVGATMKNHVDESVKDARLQHLQVLLLEQQNTFLRSKIGQKTDVLIEKPGRHSGQMVGRSPWLLPVVVDTESSTGSVVEIHIKNASSNSFVGEMTNR
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
A9IMW7
B5RE15
GCSH_SALG2
Glycine cleavage system H protein
Salmonella
MSNVPAELKYSKEHEWLRKEADGTYTVGITEHAQELLGDMVFVDLPEVGATVSAGDDCSVAESVKAASDIYAPVSGEIVAVNDALSDSPELVNSEPYAGGWIFKIKASDESELESLLDATAYEALLEDE
The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
B5RE15
Q3Z3K7
MSBA_SHISS
Lipid A export ATP-binding/permease protein MsbA
Shigella
MHNDKDLSTWQTFRRLWPTIAPFKAGLIVAGVALILNAASDTFMLSLLKPLLDDGFGKTDRSVLVWMPLVVIGLMILRGITSYVSSYCISWVSGKVVMTMRRRLFGHMMGMPVSFFDKQSTGTLLSRITYDSEQVASSSSGALITVVREGASIIGLFIMMFYYSWQLSIILIVLAPIVSIAIRVVSKRFRNISKNMQNTMGQVTTSAEQMLKGHKEVLIFGGQEVETKRFDKVSNRMRLQGMKMVSASSISDPIIQLIASLALAFVLYAASFPSVMDNLTAGTITVVFSSMIALMRPLKSLTNVNAQFQRGMAACQTLFTILDSEQEKDEGKRVIERATGDVEFRNVTFTYPGRDVPALRNINLKIPAGKTVALVGRSGSGKSTIASLITRFYDIDEGEILMDGHDLREYTLASLRNQVALVSQNVHLFNDTVANNIAYARTEQYSREQIEEAARMAYAIDFINKMDNGLDTVIGENGVLLSGGQRQRIAIARALLRDSPILILDEATSALDTESERAIQAALDELQKNRTSLVIAHRLSTIEKADEIVVVEDGVIVERGTHNDLLEHRGVYAQLHKMQFGQ
Involved in lipopolysaccharide (LPS) biosynthesis. Translocates lipid A-core from the inner to the outer leaflet of the inner membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.
Q3Z3K7
Q146K5
BIOB_PARXL
Biotin synthase
Paraburkholderia
MTQLNIAPASTDTAAASNNNAAAGTKQLARWRVADIVSLYELPFNDLMFQAQQTHREHFDANTVQLSTLLSIKTGGCEEDCAYCPQSVHHDTGLQADKLMPVDEVLAAAKVAKENGATRFCMGAAWRNPKDRHLEPIKDMIRGVKAMGLETCVTLGMLETHQAQGLREAGLDYYNHNLDTSPEFYGQIISTRTYQDRLDTLERVRDAGINVCCGGIVGLGESRRERAGLIAQLANMDPYPESVPINNLVQVEGTPLTGTEAIDPFEFVRTIAIARITMPRAMVRLSAGREQMNEALQAMCFLAGANSIFYGDQLLTTSNPQAEADRKLLERLGIRAEAAQQMPLDQSGCEHGCDKHAAPN
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Q146K5
Q6A7F0
CLPP1_CUTAK
Endopeptidase Clp 1
Cutibacterium
MNAEQAEQAAPGGLAPAGPRNDYYIPQWEERTSYGVRRVDPYTKLFEDRIIFLGTPVTDDIANAVMAQLLCLQSMDADRQISMYINSPGGSFTAMTAIYDTMNYVRPDIQTICLGMAASAAAVLLAAGAKGQRLSLPNSTVLIHQPAMGQATYGQATDIEILDDEIQRIRKLMENMLATATGQSVEQISKDIDRDKYLTAQGAKEYGLIDDILTSL
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
Q6A7F0
Q8DF67
DNAJ_VIBVU
Chaperone protein DnaJ
Vibrio
MSKRDFYEVLGVSRDASERDIKKAYKRLAMKFHPDRNQGDESAADKFKEVKEAYEILTDPQKKAAYDQYGHAAFEQGGGGFGGGFGGGGADFGDIFGDVFGDIFGGGRRGGGHARPQRGADLRYNMELSLEEAVRGVSKEIEVPTLVHCDTCEGTGAKKGTSAETCGTCHGHGQVQMRQGFFAVQQTCPTCHGKGKIIKDPCNVCHGQGRKQKTKTLNVKIPAGVDTGDRIRLSGEGEAGERGAPAGDLYVQVHVREHHIFEREGNNLYCEVPVSFAMAALGGEVEVPTLDGRVNLKVPSETQTGRMFRMRGKGVKGVRGGAIGDLIVKLVVETPVNLSSRQKELLKEFEESCCGEAATKHKPKSEGFFNGVKKFFDDLTS
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.
Q8DF67
Q21WQ0
NADD_ALBFT
Nicotinate mononucleotide adenylyltransferase
Rhodoferax
MKRIGVFGGAFDPPHVAHAALVKAALAELQLDELRVVPTGEAWHKTRTLSPAPHRLAMAQLAFAELPHVVVDPRELERVGPSYTVDTLREFKALWPTAEFFLILGEDQAQALPSWHDWQEILQLAIICVATRACSTGAGAKFDLETTHKSRFRRLLMPALNVSATDIRARFAAHLSVADMVFEPVARYIAHHHLYQTA
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
Q21WQ0
F4IE66
PRP22_ARATH
Protein ROOT INITIATION DEFECTIVE 1
Arabidopsis
MPSMAQGELKSFVQNSRPNPKSPTVSPFSMRQKIAEHRRSLPIASVEKRLVEEVQKNDILIIVGETGSGKTTQLPQFLYNAGFCREGKMIGITQPRRIAAVTVAKRVAEECEVQLGQKVGYSIRFDDTTSGSTRLKYMTDGLLLREALLDPHLSRYSVIIVDEAHDRSVHTDVLLALLKKIQRTRSQPVSEKTEFGNVASQVQTTTRDANGPQQNGVLKGYQGRKLSPLKLIIMSASLDARVFSEYFGGAKAVHVQGRQFPVDILYTVHPESDYVDATLVTIFQIHFEEKPGDILVFLTGQDEIESVERLVQERLQNIPEDKRKLLPLAIFSALPSEQQMKVFAPAPTGFRKVILATNIAETSITIPGIRYVIDPGFVKARSYDPSKGMESLDVVPASKAQTLQRSGRAGREGPGKSFRLYPEREFEKLEDSTKPEIKRCNLSNIILQLKALGIDDIVGFDFIDKPSRGAIIKALAELHSLGALADDGKLENPVGYQMSRLPLEPVYSKALILANQFNCLEEMLITVAVLSVESIFYDPREKREEARTSKNHFASVEGDHLTYLSVYRESDEFLEKRKAAGSGNNIDKIMKKWCKENYVNSRSLKHARDIYRQIREHVEQIGFNVSSCGNDMLAFRRCLAASFFLKAAQRQLDGTYRALESGEVVHIHPTSVLFRAKPECVIFNELMQTSKKYIKNLTIIDSLWLSELAPHHFQTAE
Involved in pre-mRNA splicing. Plays a role during development in processes such as meristem maintenance, leaf morphogenesis and root morphogenesis.
F4IE66
Q894H0
DXS_CLOTE
1-deoxyxylulose-5-phosphate synthase
Clostridium
MINTLDRYKDVYDIKNMSLDELNLLSRELRNFIIESVSQNGGHLASNLGVVELTLSLYNVFDFSYDKLIWDVGHQCYVHKILTGRRSGFQNLRKINGLSGFPKRCESKFDHFETGHSSTSISSALGMARARDLKGENYNVVAVIGDGALTGGMALEALNDVGDNKTKLTIILNDNQMSIGKNVGGLSTYLSSLRIDPNYNKFKRDVEGIIKKIPNIGKGVAKNLERVKDGVKQVLVPGMLFENMGIKYFGPIDGHNIKQLSKVMDKAKNMKEPVIIHVVTTKGKGYKFAEQNPDKFHGIGSFDYMTGCSKKSKGVTYSKAFGKAMVSIASKDKRVVAITAAMKDGTGLNEFSNKFKNRIFDVGIAEQHAVTMAAGMATAGLRPVFSVYSTFLQRAYDQVLHDVCIQNLPVVFAIDRAGLVGEDGETHQGVFDMSYLSHMPNMTIMAPKCVEELEFMLNWALSQESPIAIRYPKGESRLNLKPIKNFQKGKWEVLEDKGKISIIATGRMVEKAFNVKETLKERNIDIGLINATFVKPIDKEMLNKIIDEEKTIITLEDNVILGGFGNSVLNYVRDTNSNIKVVNLGFKDEFIPHGKVDDLFKMYGLDEEAILKEVMKLM
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Q894H0
P48039
MTR1A_HUMAN
Melatonin receptor type 1A
Homo
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
P48039
A5UA08
ATPD_HAEIE
F-type ATPase subunit delta
Haemophilus
MSELTTIARPYAKAAFDFAIEQSAVEKWTEMLGFAAAVAEDETVKAYLSSSLSAQKLADTVISICGEQLDQYGQNLIRLMAENKRLSAIPAVFEEFKHHVEEHQAIAEVEVTSAQPLNATQIEKIAAAMEKRLARKVKLNCNVDNALIAGVIIRTEDFVIDGSSRGQLTRLANELQL
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
A5UA08
B0XM00
LIS1_ASPFC
Lissencephaly-1 homolog
Aspergillus subgen. Fumigati
MSQLLTARQAEELHKSIIAYLASVNLTESSAALRAELGDSVSIDDATLKKYEGLLEKKWTSVVRLQKKIMDLESRCAALQSELDSATPTSLLRKNQDPTSWLPRSPARHILEGHRNPVTCVAFHPVFSSLASGSDDTTIKIWDWELGELERTVKGHTKAVLDVDYGGPRGGTLLASCSSDLTIKLWDPSDNYKNIRTLPGHDHSVSSVRFIPSGAAGSPMSGNLLVSASRDKTLRIWDVTTGYCVKTLSGHVDWVRAVAPSIDGRFLLAAGDDRIPRLWDLSSAETKSTFLGHEHVIECVAIAPAASYPHLAVLSGLKKPPPASSSAEFFATGSRDKTIRLWDSRGNLIKTLVGHDNWVRALAFHPGGKHLLSVADDKTIRCWDLTQECKCVRVISDAHGHFVTCLRWAPPLIKDGGANGEAETNGTPAATSTTNGVRPDPNVATKISIRCVIATGSVDQKVRIFAT
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
B0XM00
Q2I2Q5
CM31_CONLT
Lt3a
Elisaconus
MLKMGVLLFTFLVLFPLTTLELDTDRPVERHAAIKQDLKPQERRGIRLHAPRDECCEPQWCDGACDCCS
Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin enhances tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons.
Q2I2Q5
Q8FMB0
PURA_COREF
IMP--aspartate ligase
Corynebacterium
MAAIVIVGAQWGDEGKGKATDILGGLVDYVVKPNGGNNAGHTVVVGGEKYELKLLPAGVLSETATPILGNGVVINLEALFEEIDGLEARGADASRLRISANAHLVAPYHQIMDRVQERFLGKRAIGTTGRGIGPTYQDKVGRVGIRVQDIFDESILRQKIESALDVKNQVLVKMYNRKAIVAEETVQYFLSYADRLRPMVIDATLELNKALDEGKHVLMEGGQATMLDVDHGTYPFVTSSNPTAGGACVGSGVGPTRITSTLGIIKAYTTRVGAGPFPTELFDKWGEYLQTVGGEVGVNTGRKRRCGWYDSVIARYASRVNGFTDYFLTKLDVLTGIGEIPICVAYEVDGVRHDEMPMTQSDFHHAKPIFETMPAWDEDITGCRTFEELPQKAQDYVRRLEELSGARFSYIGVGPGRDQTIVLHDVMES
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Q8FMB0
B7LLI6
CRCB_ESCF3
Putative fluoride ion transporter CrcB
Escherichia
MLQLLLAVFIGGGTGSVARWMLSMRFNPLHQAIPLGTLAANLLGAFIIGMGFAWFSRMTNIDPVWKVLITTGFCGGLTTFSTFSAEVVFLLQEGRFGWAMLNVLVNLLGSFAMTALAFWIFSASTAN
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
B7LLI6
Q9M1U4
TCP16_ARATH
Transcription factor TCP16
Arabidopsis
MDSKNGINNSQKARRTPKDRHLKIGGRDRRIRIPPSVAPQLFRLTKELGFKTDGETVSWLLQNAEPAIFAATGHGVTTTSNEDIQPNRNFPSYTFNGDNISNNVFPCTVVNTGHRQMVFPVSTMTDHAPSTNYSTISDNYNSTFNGNATASDTTSAATTTATTTV
Required during early processes in pollen development.
Q9M1U4
B5YHP1
KAD_THEYD
Adenylate monophosphate kinase
Thermodesulfovibrio
MRLVFLGAPGAGKGTQAKRLVEKYGIPQISTGDLLRAAVAAGTPLGKEAKAYMDRGELVPDKVVLGMVKERLSQNDCKKGFILDGFPRNVAQAEALDKMLSEMNMPLDLALNLDVPFDDLMKRLTGRRTCKSCGQMYNVYYSPSKVEGKCDKCGGELFQRDDDKEETIRKRLEVYRAQTEPLIDYYSKKGILKSVSGTGSIDEIFNSICAILEKK
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
B5YHP1
Q9B5Q7
CYB_CEPSP
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Cephalophus
MTNIQKTHPLMKIVNNAFIDLPTPSNISSWWNFGSLLGICLILQILTGLFLAMHYTADTTTAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGLYYGSYAYTETWNIGVILLFATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFIFPFIIAALAMVHLLFLHETGSNNPTGISSDADKIPFHPYYTIKDILGALLLILALMILVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILVLMPLLHTSKQRSMMFRPISQCLFWILVADLLTLTWIGGQPVEHPYIIIGQLASIMYFLLILVLMPMASTIENNLLKW
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q9B5Q7
O27231
MTRE_METTH
N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit E
Methanothermobacter
MDPMITGLGVVALMGAAATIAGAAEDLESDVGSQSNPNSQVQLAPQMGHLHRIINKAVSGEPVAYGTWCGIAGSVAYVLMQSMQLPVIMAIAVGAVIAAMVHTTYAVTSHMGRIVSQSQFNQPLFMDMLVQHLGPIAGHGFIVTFCIVGLSYLMTLPIPGFAHPFPLPLLAVLWGITIGAIGSSTGDVHYGAEREYQQYPFGGGIPVAIHGDITTKAELGARNSMDVVHFCAKYGGPLTGFAFGAIVFLSFWNTIVFGITGGIISGLIIVLLLIILNNRLEVFARNRYGPYKEDE
Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step.
O27231
Q11QB9
RL16_CYTH3
50S ribosomal protein L16
Cytophaga
MLQPKRTKYRKQQKGRVTGVATRGHRIAFGSFAIKSLEGGWITARQIEAARIAMTRAMKREGQVWIRVFPDKPITQKPAEVRMGKGKGAPEYWVACIKPGTILFESGGVSIETAQESLRLAAQKLPFKTKFIVRPDYVAS
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
Q11QB9
P0DMZ9
TX9A2_ANEVI
Peptide toxin AV-2
Anemonia
MKSIFLVFFAVCLVKAEAGKGRKREPNIINPPCRECYVQDSSGNCVYDKWGCGGARKREPNIINPPCRECYVQDSSGNCVYDKWGCGGARKREPNIINPPCRECYVQDSSGNCVYDKWGCGGARKREPNIINPPCRECYVQDSSGNCVYDKWGCGGARK
Inhibits ion channels.
P0DMZ9
P13738
NHAA_ECOLI
Sodium/proton antiporter NhaA
Escherichia
MKHLHRFFSSDASGGIILIIAAILAMIMANSGATSGWYHDFLETPVQLRVGSLEINKNMLLWINDALMAVFFLLVGLEVKRELMQGSLASLRQAAFPVIAAIGGMIVPALLYLAFNYADPITREGWAIPAATDIAFALGVLALLGSRVPLALKIFLMALAIIDDLGAIIIIALFYTNDLSMASLGVAAVAIAVLAVLNLCGARRTGVYILVGVVLWTAVLKSGVHATLAGVIVGFFIPLKEKHGRSPAKRLEHVLHPWVAYLILPLFAFANAGVSLQGVTLDGLTSILPLGIIAGLLIGKPLGISLFCWLALRLKLAHLPEGTTYQQIMVVGILCGIGFTMSIFIASLAFGSVDPELINWAKLGILVGSISSAVIGYSWLRVRLRPSV
Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons . Plays an important role in the regulation of intracellular pH, cellular Na(+) content and cell volume . Catalyzes the exchange of 2 H(+) per Na(+) . This stoichiometry applies at both neutral and alkaline pH values . In addition, can also transport lithium and is involved in lithium detoxification . Binding of the Li(+) and H(+) ligands to NhaA is coupled and antagonistic .
P13738
Q7ZU13
SPNS1_DANRE
Spinster-like protein
Danio
MSQADADITPFFADDNEGEGPVENGVGSPLPEDEEEESPSGVTDRRAIMTVIVLCYINLLNYMDRFTVAGVLPDIEHFFGIGDGTSGLLQTVFICSYMFLAPLFGYLGDRYNRKLIMCVGIFFWSVVTLASSFIGKDHFWALLLTRGLVGVGEASYSTIAPTIIADLFVKEKRTNMLSIFYFAIPVGSGMGYIVGSKVDTVAKDWHWALRVTPGLGLLAVFLLMLVVQEPKRGAIEAHPEHTLHRTSWLADMKALCRNPSFILSTFGFTAVAFVTGSLALWAPAFLFRAGVFTGVKQPCFKAPCDDSDSLIFGAITVVTGILGVASGVQASKLLRTRTPRADPLVCAAGLLLAAPFLYLSIMFAQASTVATYVFIFLGETFLSMNWAIVADILLYVVIPTRRSTAEAFQIVLSHLLGDAISPYLIGVVSDSIKESNSYMWEFRSLQMSLLLCSFVAVAGGAFFLATAVFIEKDRDLAENYVPSDDAPIVVPRSGRSTKVSVSSVLI
Sphingolipid transporter.
Q7ZU13
C3PMH4
RL1_RICAE
50S ribosomal protein L1
spotted fever group
MSNKKDVAVKISGGKKIREAREKVKSDTLYNLTNAVERLKSASYVKFDPTLEIVMKLGIDSRHSDQMVRGVVNLPAGTGKTVRVAVICKEEREEEAKSAGADLVGSTNIIDEIKAGKINFDVCIATPDMMVAIGSVARILGPKGLMPNPKLGTVTLDIKNAIKNAKSGQVEYRAEKAGIIHAGLGKLSFSDQDLLKNLNAFIEAVIKAKPAGLKGSYLKAMYLSSTMGASVQIDLTSIA
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
C3PMH4