accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q37601
ATP6_PYLLI
F-ATPase protein 6
Pylaiella
MFNSPLEQFEILPLLSFGANLFDFSITNAMLTTCVSLSFFLFLFYCLFSYGLNSFPTRWQLVLEGLYTSTAGLVWDSVGPRRPKVFPFLFVIFSFILISNVQGLVPYSFTITSHLIQTMVLALTVFIGVIIIVLAHGFHMLSLFLPGGTSIVLAFLLVPIEIVSYVFKPLSLAVRLFANMMAGHTLLKVIAAVAWAMMGSGGLLLIAHIVPLGVLVILFGLELAVALIQAYVFTILSCIYINDAIVLH
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous ca...
Q37601
Q6LTY5
NQRE_PHOPR
NQR-1 subunit E
Photobacterium
MEHYLSLLVRSIFIENMALSFFLGMCTFLAVSKKVKTSFGLGVAVIVVLTIAIPVNNLVYNLLLKDGAIVDGVDLTFLNFITFIGVIAALVQILEMILDRFFPPLYNALGIFLPLITVNCAIFGGVSFMVQRDYNFVESIVYGFGSGVGWMLAIVALAGIREKMKYSDVPPGLRGLGITFITVGLMALGFMSFSGVQL
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
Q6LTY5
C4LL66
RS12_CORK4
30S ribosomal protein S12
Corynebacterium
MPTIQQLVRKGRKDKKAKVKTAALKGSPQRRGVCTRVYTTTPKKPNSALRKVARVRLTSGIEVSAYIPGEGHNLQEHSMVLVRGGRVKDLPGVRYRIIRGSLDTQGVKDRKQARSRYGAKKEK
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The com...
C4LL66
Q0ABI6
RL11_ALKEH
50S ribosomal protein L11
Alkalilimnicola
MAKKVSAYIKLQVGAGKANPSPPVGPALGQHGVNIMEFCKAFNAQTQEMEAGLPVPVVITVYNDRSFTFITKTPPAAVLLRKAAGIQKGSGEPNTKKVGTVTREQLEEIAKTKEPDLNAADLDAAVRSIAGTARSMGLDVEGL
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
Q0ABI6
P29914
NQO2_PARDE
NDH-1, chain 2
Paracoccus
MLRRLSPIQPDSFEFTPANLEWARAQMTKYPEGRQQSAIIPVLWRAQEQEGWLSRPAIEYCADLLGMPYIRALEVATFYFMFQLQPVGSVAHIQICGTTTCMICGAEDLIRVCKEKIAPEPHALSADGRFSWEEVECLGACTNAPMAQIGKDFYEDLTVEKLAALIDRFAAGEVPVPGPQNGRFSAEALGGPTALADLKGGEAHNASVARALRLGDSIKRIDGTEVPITTPWLATQNGV
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t...
P29914
Q0SSC2
PYRH_CLOPS
Uridine monophosphate kinase
Clostridium
MGTCKYKRVMLKLSGEALAGENGFGIDFNIAMNIAKAVKELVDMGIEVGAVVGGGNIWRGRSGEGMDRTTADYMGMLATSINALALQDSLESLGVDTRVQTAIEMKEIAEPYIRRRAMRHLEKGRVVIFGAGTGNPYFSTDTAAALRAAEIEADVILLAKKVDGVYDKDPHKYDDAKKYDELSYIEVLEQGLQVMDSTATSLCMDNNIPILVFALDNPENIKKVVLGENIGTIVSKK
Catalyzes the reversible phosphorylation of UMP to UDP.
Q0SSC2
Q8RWK8
COIL_ARATH
Atcoilin
Arabidopsis
MEEEKVRVRLVFEDRRILSKYQKKQGLTRSWVVLNRKCHRTISEFSDHIFHTFSLCEACPHGLSLSMEGFVLPPFESSCVLKDKDIVCVKKKKESLLEIVGEDSDENVYNAIEVEERPQIRPGEMLLANEEFQKETGGYESESEEDELEEEAEEFVPEKKASKKRKTSSKNQSTKRKKCKLDTTEESPDERENTAVVSNVVKKKKKKKSLDVQSANNDEQNNDSTKPMTKSKRSSQQEESKEHNDLCQLSAETKKTPSRSARRKKAKRQWLREKTKLEKEELLQTQLVVAPSQKPVITIDHQATKEKHCETLENQQAEEV...
Probable component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs (Probable). Required for CBs formation . Binds snRNAs and non-specific artificial RNA via the N-terminal part of the NOD domain and via the NLS2 region (212-282) of...
Q8RWK8
P56930
RL25_THETH
50S ribosomal protein L25
Thermus
MEYRLKAYYREGEKPSALRRAGKLPGLMYNRHLNRKVYVDLVEFDKVFRQASIHHVIVLELPDGQSLPTLVRQVNLDKRRRRPEHVDFFVLSDEPVEMYVPLRFVGTPAGVRAGGVLQEIHRDILVKVSPRNIPEFIEVDVSGLEIGDSLHASDLKLPPGVELAVSPEETIAAVVPPEDVEKLAEEAAAEVAEPEVIKKGKEEEEE
This is one of 3 proteins that mediate the attachment of the 5S rRNA onto the large ribosomal subunit.
P56930
P46111
KAX32_LEIHE
Agitoxin-2
Leiurus
GVPINVSCTGSPQCIKPCKDAGMRFGKCMNRKCHCTPK
Potent inhibitor of the Shaker potassium channels and its mammalian homologs (Kv1.1/KCNA1, Kv1.3/KCNA3, Kv1.6/KCNA6) (Ki<1 nM for all channels) . Also blocks Kv1.2/KCNA2 (IC(50)=26.8 nM) . It also shows a weak interaction with nicotinic acetylcholine receptors (nAChR), suggesting it may weakly inhibit it .
P46111
Q9V2R0
NADB_PYRAB
Quinolinate synthase B
Pyrococcus
MIDMEVGIVGGGLAGLVAAISLVEKGVDVSIIGPKSKDSNSYLAQAGIAFPLVEGDSIRIHVLDTIRAGKYINDEEVVWNVISKSTEAYSFLVSHGVTFTGNELEGGHSHPRVFTIKSETGKHVIPILEKHARELGVNFVRGFVEEIGIKNGKLAGVFLNGELLKFDAVVVATGGFSGLYRFTAGVKENIGLLIGDLALKGVPLRDMEFVQFHPTGFIGRRTYLITEAVRGAGAKLVTGDGERFVNELETRDVVARAIYLKMLEGKGVFLDARGIEDFKDRFPYVYSVLKKEGIDPGKDLIPVTPVAHYTMGGISVDIFY...
Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).
Q9V2R0
A1VK42
HIS6_POLNA
ImGP synthase subunit HisF
Polaromonas
MLAKRIIPCLDVTGGRVVKGVNFVELRDAGDPVEIAARYNDQGADELTFLDITATSDGRDLILHIIEAVASQVFIPLTVGGGVRTVEDVRRLLNAGADKTSFNSAALANPQVITDASAKYGAQCIVVAIDAKRRSDEDALLRGAGWDVYSHGGRKNTGLDAVAWAVEMAQRGAGEILLTSMNRDGTKSGFDLELTRAVSDAVSVPVIASGGVGNLDHLADGVQLGGADAVLAASIFHYGEYTVAQAKRHMASRGIPVRL
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
A1VK42
Q9LES2
UBA2A_ARATH
UBP1-interacting protein 2a
Arabidopsis
MTKKRKLEGEESNEAEEPSQKLKQTPEEEQQLVIKNQDNQGDVEEVEYEEVEEEQEEEVEDDDDEDDGDENEDQTDGNRIEAAATSGSGNQEDDDDEPIQDLLEPFSKEQVLSLLKEAAEKHVDVANRIREVADEDPVHRKIFVHGLGWDTKTETLIEAFKQYGEIEDCKAVFDKISGKSKGYGFILYKSRSGARNALKQPQKKIGSRMTACQLASKGPVFGGAPIAAAAVSAPAQHSNSEHTQKKIYVSNVGAELDPQKLLMFFSKFGEIEEGPLGLDKYTGRPKGFCLFVYKSSESAKRALEEPHKTFEGHILHCQKA...
Heterogeneous nuclear ribonucleoprotein (hnRNP)-like protein that acts as component of a complex regulating the turnover of mRNAs in the nucleus. Binds with high affinity to RNA molecules that contain U-rich sequences in 3'-UTRs. May function in complex with UBP1 and contribute to the stabilization of mRNAs in the nucl...
Q9LES2
B0SA20
RPOA_LEPBA
Transcriptase subunit alpha
Leptospira
MSPKNLLKGFKRPKKIEFTTDVNTPNYGKFVAEPFERGIGTTIGNSLRRTLMSSIEGAAISAIRIEGVSHEFSYIEGVAEDVTRIILNLKQVRIKYEPEDKEASKVIHLELKGAGYFRAADLAVDSSIEIMNPDLHIATLNEDANLIMDLEIQRGRGYVPAEDKKKDIEVLGTIPIDSIFSPIQKVLFEVSETRVAQRSDYEKLTMEVWTDGSVSPEDAVAQAAKILKDHLTVFINFEEEIEEEEEELDEADEKLKAALSKHVEELELSVRSTNVLRSLEIDFIGELVKRSEDEMTKSKHFSEQSLLELKAKLSSMGLSF...
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
B0SA20
Q9TKZ5
EFTU_NEPOL
Elongation factor Tu, chloroplastic
Nephroselmis
MAREKFERTKPHVNIGTIGHVDHGKTTLTAAITMVMACNTAGSKGKKYEDIDSAPEEKARGITINTAHVEYETATRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSGADGPMPQTKEHILLAKQVGVPNIVVFLNKQDQVDDEELLELVELEVRETLSNYEFPGDEVPVVPGSALLALEAMTENPSLKRGENEWVDKIFALMDAVDQYIPTPKRDTDKSFLMAVEDVFSITGRGTVATGRVERGSVKLGDTIEIVGLKPTRETTVTGLEMFQKTLDQSVAGDNVGILLRGIQKEDIQRGMVLAAPRTITPHTKFESQV...
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Q9TKZ5
Q8K9H6
DEAD_BUCAP
Cold-shock DEAD box protein A
Buchnera
MTHTESTFSFLGLNPFIIKSLSKMGYVKPSPIQAACIPLLLEGRDVLGMAQTGSGKTAAFSLPLLHNLNINLKAPQILVLAPTRELAVQVAEAFSDFSKYIMGIHVLPLYGGQRYEVQLRALRQGPQIVVGTPGRLLDHLKRGTLNLSNLYALVLDEADEMLRMGFIEDVETIMSQIPKEHQTALFSATMPEAIRRISKRFMKNPQEIKIQSNITTRPDIKQSYWMVYGRKTDALIRFLEVEDFSATIIFVKTKNATLEVSEALERNGYNSAALNGDMNQALREQTLERLKSGRLDILIATDVAARGLDVDRISFVINYD...
DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation.
Q8K9H6
Q3ED65
MENG_ARATH
Menaquinone biosynthesis methyltransferase ubiE-like protein
Arabidopsis
MAALLGIVSPVTFTGKHPVNSRSRRRTVVKCSNERRILFNRIAPVYDNLNDLLSLGQHRIWKNMAVSWSGAKKGDYVLDLCCGSGDLAFLLSEKVGSTGKVMGLDFSSEQLAVAATRQSLKARSCYKCIEWIEGDAIDLPFDDCEFDAVTMGYGLRNVVDRLRAMKEMYRVLKPGSRVSILDFNKSNQSVTTFMQGWMIDNVVVPVATVYDLAKEYEYLKYSINGYLTGEELETLALEAGFSSACHYEISGGFMGNLVAMR
Involved in the biosynthesis of phylloquinone (vitamin K1). Methyltransferase required for the conversion of 2-phytyl-1,4-beta-naphthoquinol to phylloquinol.
Q3ED65
A8AKS9
THIC_CITK8
Thiamine biosynthesis protein ThiC
Citrobacter
MSATKLTRREQRAQAQHFIDTLEGTAFPNSKRIYITGSQPDIRIPMREIQLSPTLIGGGKDNPQYEENEAIPVYDTSGPYGDPDVAINVQQGLAKLRQPWIEARADSEELTDRSSAYTKERLADDGLDELRFTGLLTPKRAKAGKCVTQLHYARQGIVTPEMEFIAIRENMGRERIRGDVLRQQHPGVGFGARLPENITPEFVRDEVAAGRAIIPANINHPESEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWSTRWGADTVMDLSTGRYIHETREWILRNSPVPIGTVPIYQALEKVNGIAEDLTWEAFRDTLL...
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
A8AKS9
Q4A7Q7
TRMB_MESH7
tRNA(m7G46)-methyltransferase
Mesomycoplasma
MRLRNIPDALERIQNQNLLVKTPWNIDDSWIIEIGMGKGKMISQLAFDNPNKNFLGVEKYPSAAVKSIKYVKKYNLSNFFILISDAKDLLDQIKGKANTIWLTFPDPWPKNRHYKRRLTYKDFLKIYANLLVKDGILKLKTDNLKFFEFSIESLKENGWKITYQTNDLHNSLVNSSNIKTTYEEKWVNLNYKIHYLEAIFI
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
Q4A7Q7
Q168P4
GCH4_ROSDO
GTP cyclohydrolase FolE2
Roseobacter
MNIHTPGLELTPDRDEAQAALDVLRQWAKQATPAEISELDPSVARLVPGMDGVEYPALSREYPSDFSLDDGYKETLPDLQNGPSSLIRGTKQQIQHVGISNFRLPIRFHTRSGGDITLETSVTGSVSLEADKKGINMSRIMRSFYKHAEETFSFEVIEAALDAYINDLESFDARIQMRFSFPMKVDSLRSGLSGYQYYDIALELVDQGGVRKKIMHLDYVYSSTCPCSLELSEHARATRGQLATPHSQRSVARISVEVENDGQCLWFEDLIEACRRAVPTETQVMVKREDEQAFAELNAANPIFVEDAARLFCEQLHSDT...
Converts GTP to 7,8-dihydroneopterin triphosphate.
Q168P4
B5F744
DAPB_SALA4
4-hydroxy-tetrahydrodipicolinate reductase
Salmonella
MHEAQIRVAIAGAGGRMGRQLIQAAMAMEGVQLGAALEREGSSLLGSDAGELAGAGKSGVIVQSSLEAVKDDFDVFIDFTRPEGTLTHLAFCRQHGKGMVIGTTGFDDAGKQAIREASQEIAIVFAANFSVGVNVMLKLLEKAAKVMGDYSDIEIIEAHHRHKVDAPSGTALAMGEAIAGALDKNLKDCAVYSREGYTGERVPGTIGFATVRAGDIVGEHTAMFADIGERVEITHKASSRMTFANGALRSALWLKTKKNGLFDMRDVLGLDVL
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
B5F744
P48040
MTR1A_SHEEP
Melatonin receptor type 1A
Ovis
MAGRLWGSPGGTPKGNGSSALLNVSQAAPGAGDGVRPRPSWLAATLASILIFTIVVDIVGNLLVVLSVYRNKKLRNAGNVFVVSLAVADLLVAVYPYPLALASIVNNGWSLSSLHCQLSGFLMGLSVIGSVFSITGIAINRYCCICHSLRYGKLYSGTNSLCYVFLIWTLTLVAIVPNLCVGTLQYDPRIYSCTFTQSVSSAYTIAVVVFHFIVPMLVVVFCYLRIWALVLQVRWKVKPDNKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLVVASDPASMAPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRQ...
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
P48040
B4TUT5
SUFS_SALSV
Selenocysteine reductase
Salmonella
MTFPVEKVRADFPILQREVNGLPLAYLDSAASAQKPNQVIDAESAFYRHGYAAVHRGIHTLSAQATESMENVRKQASRFINARSAEELVFVRGTTEGINLVANSWGTENIRAGDNIIISEMEHHANIVPWQMLCERKGAELRVIPLHPDGTLRLETLAALFDDRTRLLAITHVSNVLGTENPLPDMIALARQHGAKVLVDGAQAVMHHAVDVQALDCDFYVFSGHKLYGPTGIGILYVKEVLLQEMPPWEGGGSMISTVSLTQGTTWAKAPWRFEAGTPNTGGIIGLGAAIDYVTSLGLDKIGDYEQMLMRYALEQLAQV...
Cysteine desulfurases mobilize the sulfur from L-cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts ...
B4TUT5
Q1GK16
RS14_RUEST
30S ribosomal protein S14
unclassified Ruegeria
MAKKAMIEREKKRERLVAKYAAKRAELKEIANDESRPMEERFKARLKLAKLPRNSSATRLHNRCQLTGRPHAYYRKLKVSRIALRELGSNGQIPGMVKSSW
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
Q1GK16
O62136
INX14_CAEEL
Protein opu-14
Caenorhabditis
MIWEIPIIGDFITKPFKAAKLYEFYDRLHLFTVYLLGFFVLLTGAKQHFGNPIDCMLPKQHDDLKSWRDYIHNFCLFYGTFRYDVSNGTSEFGSYTEDASVNYYQWVPFFFAFQVCCFLLPFWCWAYMQKLIYIDMAFIVDYSGKINSEKTFEKTKEKVDRIVNYMHDHFKFRRAHKMGYLSWITFNSAFPSVLYSLTKLFFITNVIIQVNLVCKFLDVDSWTWGFDLLGKFIHPTPRAPEFSSFSDKQRFAAILTDGSYNRFQYFPILVGCEYQLQESVSNFVNHKAQCIIPMNVINEKIFIGLYFWLLVLTALSVIGT...
Structural component of the gap junctions.
O62136
A7I8L5
DHQS_METB6
3-dehydroquinate synthase II
Methanoregula
MKQFWVDARPWNKDVVTTAIESGADAVVAEKAADVKRLGRITTVAPDGDLVPGKDVIECTITDKASENEAAANGKNRIVIVTTSDWTVIPLENLVAQSDKIIAEVKNVHEAELAIHVLEKGVYGILLKTSDPAVVKAVAALVKSTSGSVQLVPFTVTKIHPVGMGDRVCVDTCSMLADGDGMLMGNTSSAMLLVHAETLENPYVAPRPFRVNAGAVHAYILLPDGKTAYLADLSIGGQVLVSDHKGAGRSAIVGRTKIERRPLLLVEATAEGGAKASLILQNAETIRLVAPDGSAISVVNLAPGNKILGCALEGGRHFGM...
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
A7I8L5
P0DTZ9
C637_CONCL
O1_cal6.37
Californiconus
MKLTCVMIVAVLLLTVCKVVTSDQLKKLRRECYLEPGDSCFHHDGRGACCEGTCFFGVACVPW
Probable neurotoxin.
P0DTZ9
A8FBM5
DCUP_BACP2
Uroporphyrinogen decarboxylase
Bacillus
MGKTKAFNDTFLKACKGEKTDHVPAWYMRQAGRSQPEYRALKEKYGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPAIGVDVEIKNGIGPVIDSPIRTKADIERLGELHPEEDLPYVLDTIQLLTKEQLNVPLIGFAGAPFTMASYMIEGGPSKNYHKTKALMYSEPETWMLLMNKLADMTITYIRAQVKAGVSAFQIFDSWVGALNAADYRTFIKPVMQRIFTELKSENVPMIMYGVGASHLVKDWHDLPLDVVGLDWRMSVDEARKEGLTKTLQGNLDPTILLSPWEVIEERAKDILDQGMKSDHFIFNL...
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
A8FBM5
Q96NR3
PTHD1_HUMAN
Patched domain-containing protein 1
Homo
MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSFQKANMLDQHHTDLILKLHAAVTKIQVPRPGFNYTFAHICILNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHLKDGRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVRLFQKSNSKVKMYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINL...
Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention.
Q96NR3
Q8G5R1
CLPX_BIFLO
ATP-dependent Clp protease ATP-binding subunit ClpX
Bifidobacterium
MGRVVSYNEDVPRCTFCGKTEHQVRKLVAGPNASICDECIALCVDIISEERVKDAEVNSLSLPKPAQIFDYLNRYVIGQENAKRALSVAVYNHYKRVNMELQESAEQLDGNNGHSGQTSKQAKQSVPTQTRATRRSNDPLADVEVAKSNILLLGPTGVGKTYLAQALARVMNVPFVITDATTLTEAGYVGDDVETVLQRLLQAADGDVSRAQHGIIYIDEIDKIARKSGENTSITRDVSGEGVQQALLKILEGTIASVPLEGTRKHKEQDVAQMDTRGILFICGGAFVGLTDIVRKRLGRRETGFGANWHDADMKDEELL...
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
Q8G5R1
F4KFS5
GMI1_ARATH
Protein GAMMA-IRRADIATION AND MITOMYCIN C INDUCED 1
Arabidopsis
MSSRRSVKRSLVLDDDDDEDIFYNFKVLLPNGTSVKLTLKNPEPEISMQSFVNLVKKEYDNARKDCLLMSKRMKVDWNSGGKFHLESNGGKMKGIVRFAAFKPDLCHIIRLDDGSGIASTMYENLWDLTPDTDLLKELPENYSFETALADLIDNSLQAVWPYREGARKLISVDISGDHITVFDTGRGMDSSEGNSIDKWGKIGASLHRSQKTGAIGGNPPYLKPYFGMFGYGGPYASMFLGRCDFSFCLPILICIVLLRLTLFSVRRTLVSSKTKESKKVFTLQFKKEALIDNRSIVGKNWKTDGGMRDPSEEEMKLSPH...
Contributes to DNA double-strand break (DSB) repair via somatic homologous recombination. Functions downstream of ATM.
F4KFS5
O13012
ESR2_ANGJA
Nuclear receptor subfamily 3 group A member 2
Anguilla
MAGSPGNELPLLQLQEVDSSKVGESGGSSGLLPTMYNGALPALSMESHAVCIPSPYTDSSHDYAALTFYSPPILSHGGPAVPESPAARQSLSPSLFWPAHGHHGHVSPLALHFQQPLVYREPAHSPWAEPKPLEHGQAQTSKLAGKRMAESEEGTSSVGGCFAGKGDMHFCAVCHDYASGYHYGVWSCEGCKAFFKRSIQGHNGYICPATNQCTIDKNRRKSCQACRLRKCYEVGMMKCGVRRERCTYRGARHRRMPHIRELAGTGGGARTQRRGEGVVPQTQEAQSSALTPEQLINRIIEAEPPEIYLMKELKKPFTED...
Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.
O13012
Q02CB5
PDXT_SOLUE
Pyridoxal 5'-phosphate synthase glutaminase subunit
Candidatus Solibacter
MKKVGVLSLQGDFAAHGAALERAGAQPVFVREREQLNQIEGLILPGGESTTMLKLLRYEDLFDDVAEFGRTKPVFGTCAGAILMAKGVTNPAQESFGLVDIEVERNAYGRQTDSRIAQVRPFPDFENRTAPGELKAVFIRAPIIRRIEDGVRVLASYQGDPVLIEQGRFLVATFHPELTDDARVHSLFLSKL
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
Q02CB5
C1D0D5
NRDR_DEIDV
Transcriptional repressor NrdR
Deinococcus
MKCPYCSAPDSKVVNSRPSDDGASIRRRRECLNCARRFTTYERAQLEPLMVVKRSGPREAFNPDKLLRGLTLATEKRPVDADALRAFAYGFEDDVQASEIHSEEIGKRAMTFLRPLDDVAYIRFASVYRDFDSLERFIEEIRGLKDQS
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
C1D0D5
B8D719
RNFB_BUCAT
Rnf electron transport complex subunit B
Buchnera
MITLIIFSFLSFLLGIILSFTAYKFRSQEDPIVEIVNELLPQSQCAQCGYSGCYPYAKAIVENSEKINKCIPGGTDLISAISSVLSIEVPEKNLIITHKKQKNNTVLINESNCVGCSKCASFCPVDAIVGAPNFIHTVLQEFCTGCNICLLHCPTNCIEIKKETYEE
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
B8D719
Q8K932
DNAB_BUCAP
Replicative DNA helicase
Buchnera
MVYPIYMAKNKSYLHQINRLKIPPHSLEAEQSVLGGLMLDNEQWDSVSEHVVADDFFSKPHRLIFQEMQQLLDLGHPIDLITLSESLEQKGKLESVGRFSYLAELSKNTPSTANIIAYADIIRERAIVREMILVANKIANAGYDTQGRKSEELLDYAESSVFKIAEKRFKKDSGPKNIEQILDETVTSIEKLFLSPNDGVTGINTGYQDLNKKTSGLQPSELIIIAARPSMGKTTFAMNLCENAAMLYDKPVLIFSLEMPGEQIMMRMLASLSRVNQARIRTGQLNDEDWSRMSGTINVLLKKKNIYIDDSSALTPSEVR...
Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins.
Q8K932
Q9Z176
P2R3D_MOUSE
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha
Mus
MPERPPIRALRRDPDDPAVAQALASLARGSDLVFPSRFQKWLRDFRQVHAHRKEEPPPQSPPPGHTVPAFYFPCGRPPPRPQDTEDAIALVECAFEGLPRGRAGLGDMAVVAKACGCPLYWKAPLFYAAGGERTGSVSVHMFVAMWRKVLLTCHDDAARFVRLLGHPGCSGLIQEDFVPFLQDVVNSHPGLAFLRAAKDFHSRYITTVIQRIFYTVNRSWSGMISREELRRSSFLQAVSQLEVEPDINRMTSFFSYEHFYVIYCKFWELDLDRDLTIDRSDLARHGDGAISSRMIDRIFSGAVTRARLPRKVGKLSYADF...
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Interacts with retinoblastoma-related protein p107 (in vivo). May target PP2A core dimer to p107 resulting in dephosphorylation of...
Q9Z176
B8F3Q0
MUKB_GLAP5
Structural maintenance of chromosome-related protein
Glaesserella
MTEKNDLFEQNVTSQNIMVATHVQSSIPSVSRSKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAGFVTALIPDLTLLNFRNTTEAGSTSSSRDKGLYGKLKAGVCYAVLESENSRGQRVISGVRLQQIAGRDKKVDIRSFSLQNINENQSVISILTEQVGEKNARVLALNDLKEKFDGSEVQFKQYHSITDYHSFLFDLGVIPKRLRTSGDRSKFYKLIEASLYGGISSVITKSLRDYLLPENTGVRQAFQDMESALRENRMTLEAIKVTQSDRDMFKKLITESTNYVSADYMRHANERRGNVQQAIEKRQ...
Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensat...
B8F3Q0
Q91619
NODAL_XENLA
Xnr-1
Xenopus
MAFLTAVLYLGFACISQGLPTWPDRVESRNPLFGSRVALNLPSLLDGNRHHRDMRYPLYMMQLYQNLVTGNDTGLANRPNTATKEYDTVLSLFAKKCTESENRWTLSFDMSAVSRSNELKLAELRILLPHTEPSHNITMDMYHSRDGEDNLYLGSFNANPPSTKGSPWKVFNVTKILQPYFKERRDIDSEHLKAKERAERGSGMSNAEFIDAPGPSQQYNPHQTSVPTYLNTKGVMLVLFTKVKSSANHIGFPSLIKTAESSKYVDIEKASRVPGIRRHRRNRNENHHLSIGSIPSRHVENGKPLCRRVDMIVDFEDIGW...
Cooperation and regulatory loops of multiple nodals are essential for mesendoderm patterning in early embryos. Essential for mesoderm formation and axial patterning during embryonic development. Activates the activin-like signaling pathway to induce dorsal and ventral mesoderm in animal cap ectoderm. In addition, also ...
Q91619
Q2NYE3
RL13_XANOM
50S ribosomal protein L13
Xanthomonas
MTTFTAKSETVQRDWYLVDAAGKTLGRLSTELARRLRGKHKPVYTPHVDTGDYLVVINAEKIVVTGNKLKDKKYHRFTGYIGNLKTESLEQALQRHPERVIEIAVKGMLPKGPMGRTMYRKLKVYSGAEHPHAAQQPQVLDI
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Q2NYE3
Q8KBK8
RECX_CHLTE
Regulatory protein RecX
Chlorobaculum
MDEGKKSSALDHALRLLAGRAHGRAELESKLKKKGFDSESIAKALARLDELNLTDDRAFAQSCTASMARRKPEGRLKTRARLKQKGLPDNIIDEALNGCDQTELCRSAAEKKLRTLPASPDQKKKKLITFLKNRGFDWETIRETVKLVLGEESARSDQLD
Modulates RecA activity.
Q8KBK8
B4T3B0
NORR_SALNS
Anaerobic nitric oxide reductase transcription regulator NorR
Salmonella
MSFSVEVLAGIAIELQRGIGHQDRFQRLITTLRQVLACDASALLRYESRQFIPLAIDGLAQDVLGRRFTLEGHPRLEAIARAGDVVRFPADSDLPDPYDGLIPGQESLKVHACVGLPLFAGQNLIGALTLDAMTPEQFEVFSDEELRLVAALAAGALSNALLIEQLESQNILPGSSGVFEPIKETHMIGLSPAMTQLKKEIEIVAGSDLNVLIGGETGTGKELVAKAIHQGSPRAVNPLVYLNCAALPESVAESELFGHVKGAFTGAISNRSGKFEMADNGTLFLDEIGELSLALQAKLLRVLQYGDIQRVGDDRSLRVD...
Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.
B4T3B0
Q8FJN1
DING_ECOL6
ATP-dependent DNA helicase DinG
Escherichia
MALTAALKAQIAAWYKALQEQIPDFIPRAPQRQMIADVAKTLAGEEGRHLAIEAPTGVGKTLSYLIPGIAIAREEQKTLVVSTANVALQDQIYSKDLPLLKKIIPDLKFTAAFGRGRYVCPRNLTALASTEPTQQDLLAFLDDELTPNNQEEQKRCAKLKGDLDTYKWDGLRDHTDIAIDDDLWRRLSTDKASCLNRNCYYYRECPFFVARREIQEAEVVVANHALVMAAMESEAVLPDPKNLLLVLDEGHHLPDVARDALEMSAEITAPWYRLQLDLFTKLVATCMEQFRPKTIPPLAIPERLNAHCEELYELIASLNN...
DNA-dependent ATPase and 5'-3' DNA helicase.
Q8FJN1
Q5REG6
ZC11A_PONAB
Zinc finger CCCH domain-containing protein 11A
Pongo
MPNQGEDCYFFFFYSTCTKGDSCPFRHCEAALGNETVCTLWQEGRCFRQVCRFRHMEIDKKRSEIPCYWENQPTGCQKLNCAFHHNRGRYVDGLFLPPSKTVLPTVPESPEEEVKASQLSVQQNKLSVQSNPSPQLRSVMKVESSENVPSPTHPPVVINAADDDEDDDDQFSEEGDETKTPTLQPTPEVHNGLRVTSVRKPAVNIKQGECLNFGIKTLEEIKSKKMKEKSKKQGEGSSGVSSLLLHPEPVPGPEKENVRTVVRTVTLSTKQGEEPLVRLSLTERLGKRKFSAGGDSDPPLKRSLAQRLGKKVEAPEANID...
Involved in nuclear mRNA export; probably mediated by association with the TREX complex.
Q5REG6
B3A0Q6
CAH2_LOTGI
Putative carbonic anhydrase 2
Lottia
AYRQTENLLYGRSFHAEAHIVHHHSDFADVAEASKHLGGIAVVSIFLTNDKQRYNPTTNRALDTILNHLKDLIEFTEEEHVCRAENRRIKRTGIYSKLGVERACRENNPNYDADSPDGDPSNKCQLHKKARGCGDPIENVTFNPNDLLSSIPTYLTFEGGLTTPPCSESVIWIVAEHPAYISNKNIEYMNKLKSRIVNQTISDFGNLRPLHDPAERDVFRIIYGRYPPRREEDDERGDGRHDLRDDDDNYDDDDYYNDDYSNDDYYDDDYYYDDYDDDTDDDHKDDGRRDRGGGDDKGGRGKGDDRGGRDNGDNRTGRGN...
Reversible hydration of carbon dioxide.
B3A0Q6
A6T2E3
ZAPD_JANMA
Z ring-associated protein D
Janthinobacterium
MIVYEYPFNERIRTLLRLEDLYEKFAFFIGQDHPQHHHVALATMFEMLEVAGRADLKSDLLQELERQKQTLLGFKSNPNVEAEMLDAILFDLDRISAALIASQGKTGQHIRENEWLMSIRGRTIIPGGACEFDLPSYYAWQHDSAEQRLADIHKWFTPLAPLFDAIGMVLRLLRESGRPVKMIAQTGSYQQMLQGKAYQMLRLNIDEALGAIPEISANKYMLWIRFTSQDGDMKPKAFEGDVPFELSLCSF
Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity.
A6T2E3
Q7NYT5
AROC_CHRVO
5-enolpyruvylshikimate-3-phosphate phospholyase
Chromobacterium
MSGSSMGRLFTVTSFGESHGPGIGCVVDGCPPGLALSEADIQLELDRRKPGTSRHVTQRREPDTVEILSGVYEGKTTGTPIALLIRNTDQRSKDYGNIADTFRPGHADYCYWHKYGTRDPRGGGRSSARETAVRVAAGAIAKKWLNEKYGIVIRGHMTQIGEVAIPFKSWEHVGGNPFFSADPDIVPRLEEYMDSIRKSLDSIGARLRVVADNVPVGWGEPVFDRLDADIAYAMMSINAVKGVEIGAGFGCVTQKGSEHGDELTPRGFASNHAGGVLGGISTGQQIDVSIAIKPTSSIAQPRRSINKQGEAVTMETHGRH...
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a s...
Q7NYT5
Q8KAJ8
RPOA_CHLTE
Transcriptase subunit alpha
Chlorobaculum
MIYQMQMPTKIDVDEATHTGSFGRFIAQPLERGYGVTLGNAMRRVLLASLPGTAITGIKIDGVFHEFSTIDGVREDVPEIVLNLKKVRFKSNCKRSCKTTLTLAGPKDFLAGDIVAQEGEFEVLNKDLHIATINSEATVTIDIYIGRGRGYVPAEENRSDGMPIGFIAIDSIYTPIKNVKLTVENTRVGQKTDYEKMILDVETDGSITPDDAISLAGKIINDHITFFANFSPTEEEFSEEEYKQLDDEFESMRKLLQTKIEDLDLSVRSHNCLRLAEIDSLGDLVSRREEELLNYKNFGKKSLTELKEQLEKFNLKFGMD...
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q8KAJ8
B6YTZ4
PFDB_THEON
GimC subunit beta
Thermococcus
MQNIPPQVQAMLGQLEGYQQQLQLVIQQKQKVQLELTEAKKALEEIEKVEEGTVIYKTVGTLIVKTDKAKALEELKEKVETLEVRLNALERQEKKLNEKLKELTQKIQTALRPTAG
Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
B6YTZ4
Q8WWL7
CCNB3_HUMAN
G2/mitotic-specific cyclin-B3
Homo
MLLPLPPQSSKPVPKKSQSSKIVPSHHDPSEKTGENCQTKISPSSLQESPSSLQGALKKRSAFEDLTNASQCQPVQPKKEANKEFVKVVSKKINRNTHALGLAKKNKRNLKWHKLEVTPVVASTTVVPNIMEKPLILDISTTSKTPNTEEASLFRKPLVLKEEPTIEDETLINKSLSLKKCSNHEEVSLLEKLQPLQEESDSDDAFVIEPMTFKKTHKTEEAAITKKTLSLKKKMCASQRKQSCQEESLAVQDVNMEEDSFFMESMSFKKKPKTEESIPTHKLSSLKKKCTIYGKICHFRKPPVLQTTICGAMSSIKKPT...
Cyclins are positive regulatory subunits of the cyclin-dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Its tissue specificity suggest that it may be required during early meiotic prophase I.
Q8WWL7
B0B875
RUVA_CHLT2
Holliday junction ATP-dependent DNA helicase RuvA
Chlamydia
MYEYIKGTLTHIDGSYVVIESFGIGYAIMLSERFLVDLRAFMHQEVLIYVHSVIRETEHVLYGFSSRAERECFRLLISFSGIGPKTGLSILNMFPLQELCSIARLENVKAIASVPGIGKKTAEKLMVDLKQKLPTLMPLYLEEPVVPSSTANSSFKEGIGALMNLGFSRLAADRMMTEAVKELSEEASVAELLPIALRKS
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA...
B0B875
F4KFT7
TENAC_ARATH
Aminopyrimidine aminohydrolase
Arabidopsis
MRFLFPTRLINNSSLGLLRSPHTTAPIRSLWFRTKSPVFRSATTPIMTAVAFSSSLSIPPTSEEALPGKLWIKFNRECLFSIYSPFAVCLAAGNLKIDTFRQYIAQDVHFLKAFAHAYELAADCADDDDDKLAISDLRKSVMEELKMHDSFVQDWDLDINKEVSVNSATLRYTEFLLATASGKVEGCKAPGMLDTPFEKTKVAAYTLGAVTPCMRLYAFLGKEFGSLLDLSDVNHPYKKWIDNYSSDAFQASAKQTEDLLEKLSVSMTGEELDIIEKLYQQAMKLEVEFFHAQPLAQPTIVPLLKNHSKDDLVIFSDFDL...
May be involved in the salvage of thiamine breakdown products . This protein has a haloacid dehalogenase family domain fused to its TenA domain . Phosphatase with the highest activity against thiamine monophosphate (ThMP) and, with a lower activity, against thiamine diphosphate (ThDP), flavin mononucleotide, inorganic ...
F4KFT7
Q921J2
RHEB_MOUSE
Ras homolog enriched in brain
Mus
MPQSKSRKIAILGYRSVGKSSLTIQFVEGQFVDSYDPTIENTFTKLITVNGQEYHLQLVDTAGQDEYSIFPQTYSIDINGYILVYSVTSIKSFEVIKVIHGKLLDMVGKVQIPIMLVGNKKDLHMERVISYEEGKALAESWNAAFLESSAKENQTAVDVFKRIILEAEKIDGAASQGKSSCSVM
Activates the protein kinase activity of mTORC1, and thereby plays a role in the regulation of apoptosis. Stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling. Has low intrinsic GTPase activity.
Q921J2
Q9BSK2
S2533_HUMAN
Protein PNC1
Homo
MATGGQQKENTLLHLFAGGCGGTVGAIFTCPLEVIKTRLQSSRLALRTVYYPQVHLGTISGAGMVRPTSVTPGLFQVLKSILEKEGPKSLFRGLGPNLVGVAPSRAVYFACYSKAKEQFNGIFVPNSNIVHIFSAGSAAFITNSLMNPIWMVKTRMQLEQKVRGSKQMNTLQCARYVYQTEGIRGFYRGLTASYAGISETIICFAIYESLKKYLKEAPLASSANGTEKNSTSFFGLMAAAALSKGCASCIAYPHEVIRTRLREEGTKYKSFVQTARLVFREEGYLAFYRGLFAQLIRQIPNTAIVLSTYELIVYLLEDRT...
Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria . Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism . Also transports guanine but not adenine (deoxy)nucleotides . Is inhibited strongly by pyridoxal 5'...
Q9BSK2
C0ZIY1
PSUG_BREBN
Pseudouridine-5'-phosphate glycosidase
Brevibacillus
MKQYLTFTEEVRHALENNLPVVALETTIISHGMPYPQNIEMAKEVEQIIRDNGAVPATIGIMDGKIKIGLTDSELEEFATNKNVAKVSRRDFAYILASGKIGATTVAATMIAAEMAGIHMFATGGIGGVHREGEITWDVSADLTELAQTDVAVVCAGAKSILDIGRTLEYLETQGVPVVGYRTDEFPSFFARKSGFGVDMRIDTPEEVGKMMNTKWDLGLKGGMIIANPVPESDALNHEEIEAVIQKALAEAKENNIAGKQVTPFMLDKVKKLTEGKSLATNIALVKHNAEVAAKIAVAYQKEANQGK
Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.
C0ZIY1
A9BG28
APT_PETMO
Adenine phosphoribosyltransferase
Petrotoga
MEIVDLKKWIRDIPDFPEKGVIFRDITPLLKNPEVFKYSVEKIAELIKEWDFDCIVSPESRGFIFATPLAYLMNKEFVPIRKPGKLPYKTYSISYELEYGQTSLEMHVDAIDKGEKVIVVDDVLATGGTTKAIKELVDRAGGKTVGVVCLAELTYLNPRENLKDLEIASLIRY
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
A9BG28
Q46L08
UVRC_PROMT
Excinuclease ABC subunit C
Prochlorococcus
MELTPLIRDKSRLSDFLKDIPNDPGCYLMKDGEDRLLYVGKSKKLRNRVRSYFRSGNELSPRISLMVRQVADIELIVTDNESEALTLESNLIKSHQPYFNVLLKDDKKYPYVCITWGDKYPRIFLTRKRRQRQLKDKYYGPYVDVYLLRQTLFSIKKLFPLRQRRIPLYKDRTCLNYSIGRCPGVCQEEISSEDYKNTLKRVEMIFQGRTDELRILLEKQMISFSESLKFEEAGSVRDQLKGIDRLYESQKMIIPDSSVCRDIIAMASEENISSVQIFQMRSGKLIGRLGYFSDNSNFNSSQILQQVIENHYSNVDPVEI...
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q46L08
P14748
DCE1_FELCA
Glutamate decarboxylase 67 kDa isoform
Felis
MASSTPSSSATSSNAGADPNTTNLRPTTYDTWCGVAHGCTRKLGLKICGFLQRTNSLEEKSRLVSAFKERQSSKNLLSCENSDRDGRFRRTETDFSNLFARDLLPAKNGEEQTVQFLLEVVDILLNYVRKTFDRSTKVLDFHHPHQLLEGMEGFNLELSDHPESLEQILVDCRDTLKYGVRTGHPRFFNQLSTGLDIIGLAGEWLTSTANTNMFTYEIAPVFVLMEQITLKKMREIVGWSSKDGDGIFSPGGAISNMYSIMAARYKFFPEVKTKGMAAVPKLVLFTSEHSHYSIKKAGAALGFGTDNVILIKCNERGKII...
Catalyzes the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) with pyridoxal 5'-phosphate as cofactor.
P14748
P10488
ALBR_KLEOX
Albicidin resistance protein
Klebsiella
MYDRWFSQQELQVLPFADEDEQRNQTWLELVGEAQQLMANAARQMSRGRLRWQPAGWSSWSRIHRHAEFLTRLNEMHAAEPQMREQTGVTPEMIDFITRAFAESKLAIWARYLNAEELAFTRQHYFDRLMEWPALVADLHRACREKRDRPPRKVSSWRSAAWRCSSLTRVKMRRRSRISLCHAQVPALMKGTWMTSEVLSWLQQAIGVMMRQAQGPRE
Albicidin resistance protein binds to form a complex without antibiotic activity but without catalyzing any further chemical modifications to albicidin.
P10488
A2BSS2
RNZ_PROMS
tRNase Z
Prochlorococcus
MNITFLGTSSGVPSLTRNVSSLALKLSQSAEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGLSGNSEGIEIYGPSELRSFINSALKSSFCKLSFPLHFVEVENFALKNKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPGVFDIKKAESLKIAPGPIYSELQQGKKVVLPDGRTFDGKEFCGPPREGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQTDERMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNSITPGDLLKEAQKVFPNTHLAKDFLTAEIK
Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
A2BSS2
A7FRB3
TRMB_CLOB1
tRNA(m7G46)-methyltransferase
Clostridium
MRLRKKWWARPEIEASDKFAEEPKELRGKWNKEFNNNNDIHLELGCGRGGFISQLVEKNKDINYVGIDLKDEVIVYAIRKVKEKEEEVKREFKNIKFVTMNIMGIAEVFDKNEISKIYINFCNPWPKERHNKRRLTHTKLLTEYKKFLKPNTEIWFKTDDKELFEDSQEYFKESGFNIEYITYDLHNSDFKENIKTEYETKFETMGMKIMFLKARLL
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
A7FRB3
A5VUS6
GATA_BRUO2
Glutamyl-tRNA(Gln) amidotransferase subunit A
Brucella
MSELTALTIAEARDKLKAKAITATELTDAYLSAIDAANDAINAYVAVTHDQARSMAKASDERIAKGEAGALEGIPLGVKDLFATKGVHTQACSHILDGFKPEYESTVTANLWADGAVMLGKLNMDEFAMGSSNETSYYGPVKNPWRAKGSNADLVPGGSSGGSAAAVAAHLCAGATATDTGGSIRQPAAFTGTVGIKPTYGRVSRWGTVAFASSLDQAGPIARDVRDAAILMKSMASLDLKDTTSVDLPVPDYEAALGRSVKGMKIGIPREYRVDGMPGEIEELWQKGIQYLKDAGAEIVDISLPHTKYALPAYYIVAPA...
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
A5VUS6
Q6VGS5
DAPLE_MOUSE
Dvl-associating protein with a high frequency of leucine residues
Mus
MDVTVSQLVELFLQSPLVTWVKTFGSFGSGHQDNLTLYMDLVDGIFLNQIMLQIDPRPSNQRINKHVNNDVNLRIQNLSILVRNIKTYYQEVLQQLIVMNLPNVLMIGKDPLSGKSMEEIKKVLLLVLGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLDLPDVAPEELEALSRNMVFHLRRLIDERDECTELIVDLTQERDYLQTQQPPSPGKFSSPDSTPSPTSSLSSEDKQHLAVELADTKARLRRVRQELEEKTEQLADTRHEVDQLVLELQKAKQDNIQLAADARSARAYRDELDSLRE...
Required for activation of guanine nucleotide-binding proteins (G-proteins) during non-canonical Wnt signaling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signaling. Acts as a non-receptor guanine nucleotide exchange factor by also bind...
Q6VGS5
O04161
AMT12_SOLLC
LeAMT1;2
Solanum subgen. Lycopersicon
MASAMTCSAAELFPHLGSSANATAAAEFICSRFSAVSEYLTNTTYAVDTTYLLFSAYLVFAMQLGFAMLCAGSVRAKNTMNIMLTNVLDAAAGGFSYYLFGFAFAFGAPSNGFIGKHFFGLKEFPSQAFDYSYFLYQWAFAIAAAGITSGSIAERTQFVAYLIYSSFLTGFVYPIVSHWFWSGDGWASASKTDGNLLLRFGVIDFAGSGVVHMVGGIAGLWGAFIEGPRIGRFDRSGRSVALRGHSASLVVLGTFLLWFGWYGFNPGSFLTILKSYDHTIRGTYYGQWSAIGRTAVTTTLAGCTAALTTLFCKRLLVAHW...
Ammonium transporter probably involved in ammonium uptake from the soil.
O04161
Q480C4
CLPS_COLP3
ATP-dependent Clp protease adapter protein ClpS
Colwellia
MSNWKELFDTEGIVEESVKEQIEEPAKYYVFLLNDDYTPMDFVVDVLCNFFNKSEEQATDIMLTIHYKGKALCGTYTAEIAETKVEQVVQYAFENQHPLKCVMTKA
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
Q480C4
Q3SVQ1
GLO2_NITWN
Glyoxalase II
Nitrobacter
MTADIRLFTCLTDNFGVLIHDPATGATAAIDAPEAEPVIQALDREGWVLTDILITHHHSDHVGGVAELKRKYACRVVAPHDRSAEIANVDLRVGQGDIIKVGTLLGRVLETPGHTLDHVSYVFDDEKVVFAADTLFSIGCGRVFEGTYPMMWDSLLKLRALPDSFRLYCGHEYTDSNIKFALTIEPNNPVLKARAEEVTRLRAEGRPTVPTLMGEEKKANVFLRADDPAVAAGVHMKGASGVEVFAELRERKNKS
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid.
Q3SVQ1
Q9Z2H2
RGS6_MOUSE
Regulator of G-protein signaling 6
Mus
MAQGSGDQRAVGIADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTDETQSQSPVHIPSQPIRKTTKDDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPFITPAEPSNPWISDDITLWDIE...
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity.
Q9Z2H2
O84863
FUMC_CHLTR
Iron-independent fumarase
Chlamydia
MRQENDSLGIVLVPEDKLFGAQTGRSQEFFSYGKESMPLEIIHALVKIKKCAAKANGDLGCLDAKRRDMIVAATDEILSGEFDEHFPLKVWQTGSGTQSNMNVNEVIANLAIQRHGGELGSKHPVHPNDHVNKSQSSNDVFPTAMHIAAVQSIKGSLIPALEHLKKVIDAKALEFARDIKIGRTHLMDAVPMTLGQEFSGYSCQLHNCLERIGFSLTHLYELAIGGTAIGTGLNVPEGFVEKVIQYLRRETGEPFVPASNYFAALSNHDALVQAHGSLTVLACALVKIATDLSFLGSGPRCGLGEIFFPENEPGSSIMPG...
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
O84863
A5CD12
SYT_ORITB
Threonyl-tRNA synthetase
Orientia
MIDIILPDGSVKQYKIGVTGQEIIQSLSISLFKKTIAVEINNELIDLYIPIINTATVKAITIDSVQGIEILRHDTAHILAQAVKKLFPDTQVVIGPVIKDGFYYDFARDKPFTNKDLEVIEQEMQDIIAKNDLIQREVWLRAKAIEFFKQQKEFYKVKLIEEIPESEEISIYRQGNFVDLCRGPHSPSTGYCTKYFKLTKVSGAYWRGNSKNEVLQRIYGTAWEKKSDLDSYLHRLSEAQKRDHRKLGRELELFHFQDEAQGMPFWHDKGWTIFKIIKNYISCQIQRAGYIEVNTPMVLSQKLWEKSGHWEKFRENMFTL...
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
A5CD12
Q5YPG2
RS7_NOCFA
30S ribosomal protein S7
Nocardia
MPRKGPAPKRPLINDPVYGSPLVTQLVNKILLDGKKSTAERIVYGALEQAREKTGTDPVVTLKRALDNVKPSLEVKPRRVGGATYQVPVEVRPGRANTLALRWLVNFARARREKTMVERLANELLDASNGLGASVKRREDTHKMAESNRAFAHYRW
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
Q5YPG2
Q6CW75
THG1_KLULA
tRNA-histidine guanylyltransferase
Kluyveromyces
MAKSRFEYVRQFEVHDALLPDTYIVVRVDGKKFHEFSKYYNFAKPNDERALKLMNAAAKNVFMQYKQEMICAYGESDEYSFILKRDTKLFNRRRDKISTLFVSLFTANYVSLWNLFFPDVVLHHKHLPYFDSRCVCYPNLTVVKDYLSWRFVDTHINNLYNTVFWYLIIKCGLTPQESEQKLCGTLSSDKQEILFSECGINYNNEPEMYKKGSLVNSKGEIVHIDVVKQIDEIFNGF
Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.
Q6CW75
O26778
RRP42_METTH
Exosome complex component Rrp42
Methanothermobacter
MVNKMDIIPEITRKSITDLINNKERIDGRSLHEFRDISIETGVISKAEGSSRVKLGNTQIIVGVKPQIGEPFPDTPEMGVILTNSELLPMASPTFEPGPPDERSVELSRVVDRCIRESRMIDLEKLCIIEGSKVWMLFLDLHIIDYDGNLFDAAVLATVAALLDTRIPAAEVEDGEVVINREKMQPLPVNRKALMCTFAKIGNEIVLDPSLEEEDILTARISIGVTEEGSICAMQKGGEGPLTRDDVLKAVSIAVEKVPQLIEYLDKSMTP
Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site.
O26778
Q14JC0
RL3_FRAT1
50S ribosomal protein L3
Francisella
MSLGLVGRKCGMTRIFTEDGVSIPVTVVQVEPNKVTQVKTVEKDGYNAIQVTTGFKKRSNVNKPMAGHYAKASVEPGRGLWEFTVDAAAEYQVGSSFDATMFEAGQKVDVRGVSKGKGFQGGVKRHNFATQDATHGNSLSHRVHGSTGQNQTPGRVFKNKKMAGHLGNENVTIQSLEVVRVDAENGLLLLKGGIPGSVGGDIIVTPAVKSW
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Q14JC0
Q8CXK0
UPPP_OCEIH
Undecaprenyl pyrophosphate phosphatase
Oceanobacillus
MNVFENFWTIVHYFVLGLVQGITEPIPISSSGHIIIFRELFGIEARGLSFEIFVNLASLLAVLIIYRKDIVRLAVNSWNFIFKQEKESKSDFMFVVYLVLATIPVGIVGVLFGDEIGAFIGEDGTTVVGITLLITAAAIWMIRNLRGRKIEGDLSTKDAVIVGLAQAVAVTPGISRSGATLVASMLMGMKQDTALRFSFLLYIPVSLGSSILEIPNIVRDPNVQELWIPYLVAFITAFIASYFALKWFMNIMRHGNLKYFAYYCVIVGVLVLIFL
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Q8CXK0
B7NFW8
G6PI_ECOLU
Phosphohexose isomerase
Escherichia
MKNINPTQTAAWQALQKHFDEMKDVTIADLFAKDGDRFSKFSATFDDQMLVDYSKNRITEETLAKLQDLAKECDLAGAIKSMFSGEKINRTENRAVLHVALRNRSNTPILVDGKDVMPEVNAVLEKMKTFSEAIISGEWKGYTGKAITDVVNIGIGGSDLGPYMVTEALRPYKNHLNMHFVSNVDGTHIAEVLKKVNSETTLFLVASKTFTTQETMTNAHSARDWFLKAAGDEKHVAKHFAALSTNAKAVGEFGIDTANMFEFWDWVGGRYSLWSAIGLSIVLSIGFDNFVELLSGAHAMDKHFSTTPAEKNLPVLLALI...
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
B7NFW8
Q3IIQ6
PURA2_PSET1
IMP--aspartate ligase 2
Pseudoalteromonas
MPSIVVVGANWGDEGKGRIVDFLAENASASIRFQGGNNAGHTVVNDFGTFKLHQLPSGIFNPDCIAVLGPGMVISPSALSEEIAEVKAAGVNVKLCISDRATLCLPLHALEDTLEELRLGDAAYGSTRQGISPAYGDRVMKKGILVGWLNQPDVLLERIQFMLDWKMPQLKALYPSCDFSQTAEEMTQWLLDVTAPWRAFICNVTEPLKALQKQNANLLFEAQLGAGRDLVYGEYPYTTSSNVTAAYAGIGSGLPALRPERVVAVAKSFSSSVGTGTLVTAMEEQDNFRESANEYGAVTGRPRDMGYFDAVATRNGVELQ...
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Q3IIQ6
Q12EL5
MURG_POLSJ
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
unclassified Polaromonas
MSEHVRSAGPPQASTAPSGGSAVHEVTSVGARVALVMAGGTGGHIFPGLAVAEALRERGWRVHWLGGRGNAGHPSMESQLVPPRGFAFESIDFSGVRGKGPLTLVFLPLRLLKAFWQSIQVVRRVKPDVVVGLGGYIAFPAGMMSVLLGKPLVLHEQNSVAGMVNKVLAGVADRVFTAFPGVFRKAEWIGNPLRPAFIRQPDPATRFAGRAGPLKLLVVGGSLGAKALNELVPRALALMPPAQRPDVTHQSGIRQIDELRANYAAAGVQAELTPFIEDTAQAFADADLIICRAGASTVTEIAAVGAAALFVPFPSAVDDH...
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Q12EL5
A0RQ36
NAPA_CAMFF
Periplasmic nitrate reductase
Campylobacter
MDRREFIKSSAAAAACSAAGIAVPSSLSAAENQDGWRWDKSACRFCGTGCGIMVATKNGKIVAVKGDPLAPVNRGLNCIKGYFNAKIMYGEDRITKPLLRVNANGEFDKKGKFQEVSWKRAFDEMEKQFRKTYAELGPTGIGVFGSGQYTIQEGYAISKLIKGGFRSHNIDPNARHCMASAVVGFMQTFGIDEPAGCYDDIELTDTIVTWGANMAEMHPILWSRVSDRKLQNSDKVKVVNLSTYSTRTSNIADIEIIFTPHTDLAIWNYIAREIVYNHPEAIDEEFVKANCVFTTGPVDIGYGMRANIKHPKYLPSELDT...
Catalytic subunit of the periplasmic nitrate reductase complex NapAB. Receives electrons from NapB and catalyzes the reduction of nitrate to nitrite.
A0RQ36
Q65JJ1
SYP_BACLD
Prolyl-tRNA synthetase
Bacillus
MRQSRTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMPLANKVIHKIQSIVREEMEKINAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGREFALGATHEEVITSIVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDAYSFHSSAESLDETYNDMYQAYTNVFTRCGLNFRPVIADSGAMGGKDTHEFMALSDVGEDTIAYSDQSSYAANIEMAEVKETDAGEQAEMKELQEVHTPSVKTIEEVAAFLGISPSDCIKSMLMKADGRFVLVLTRGDHEVNDVKVKNLLQAEIIEFASAE...
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two addit...
Q65JJ1
A3NR15
TRML_BURP0
tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL
pseudomallei group
MFNVVLVEPEIPPNTGNVIRLCANTGARLHLIEPLGFPLDDAKMRRAGLDYHEYAQMRVHRDWDAFVAAEAPDPARMFAFTTRGSGRFHDRAFEPGDWFVFGAETRGLAPALVDRFAPEQRVRLPMRPGNRSLNLSNTVAVVVFEAWRQAGFEGGA
Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.
A3NR15
O55222
ILK_MOUSE
p59ILK
Mus
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLAKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHAL...
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be impli...
O55222
B8N0Q7
MDM34_ASPFN
Mitochondrial distribution and morphology protein 34
Aspergillus subgen. Circumdati
MAFNFNWSPLMADASFYTRAQDLLTAALNKSPKPPIIVDDIIVTELNLGSIPPDLEILEIGDLAEDRFRGIFKMSYTGDAFLTLKTRVQANPLNTYLLTRPSFASPLPLAAATPLTIPLQITLSDFKLSGFVILVFSKQKGITVVFRNDPLESLKVSSTFDSIPFVRDFLQREIEAQLRILFMDELPAIIHRLSLRLWVPEYRAGEDIQTQPEQTAGEGPGQDPLASPPQDPVDSLGNALDESEIASLSLDSSVEAHSLFSQKNLLRLGALTDSQRTLSLFTPSIQEVVYRAWTSPSEQGDANGISTAPLSPMLSRTHSQ...
Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. Mdm34 i...
B8N0Q7
Q06GZ1
ATPE_DRIGR
F-ATPase epsilon subunit
Drimys
MTLNLCVLTPNRIIWDSEVKEIILSTNSGQIGVLPNHAPIATAVDIGILRIRLNDQWLTMALMGGFARIGNNEITILVNDAERGSDIDPQEAQRTLEIAEASLSRAEGKRQEIEANLALRRARTRVEAINVISY
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Q06GZ1
Q1CYI2
QUEC_MYXXD
Queuosine biosynthesis protein QueC
Myxococcus
MVKRAVVLISGGLDSTTCLAMAKAKGFEPVCLAVAYGQRHAVELEQARKVAAAMGVTDFRVVSIDLRQVGGSALTADIEVPKDRPSDEMSHGIPVTYVPARNALFLSLALGLAEVVGSTDIYIGVNAVDYSGYPDCRPEFIRSFESMANLATKAGVEGAHFTVHAPLSGLTKADIIREGVKLGVDYGLTHSCYDPDAQGRACGRCDSCVLRKKGFEEAGVPDPTRYTESA
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
Q1CYI2
Q0I604
MRAY_SYNS3
UDP-MurNAc-pentapeptide phosphotransferase
unclassified Synechococcus
MKERDVNDAQETPPPLEGKVSAGVLAVVVYAAAFASDRWIPNSLLSLPLLIATLIAAIVTWWGVPKLRGLKLGQVIREEGPQAHLTKSGTPTMGGLLVVPVGVIVGGLISWSGQAAEQLLAVAFITLAYMVVGGIDDWRSLTKHTNTGLTPRGKLLLQALAAVIFLIWAGMRGWISGDVALPFDINLPLNWLIWPLAVFVFLAESNATNLTDGLDGLAAGCGALVFTGMALQLTLRGNSGDPSLAGFCMAMAGCWIGFLVHNRNPAKVFMGDTGSLAMGGALTAVALLTNSLWPLLIMGGIFLAESLSVIIQVWVFKATK...
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I...
Q0I604
O79226
CYB_PUFOP
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Puffinus
MAPNLRKSHPLLKMVNNSLIDLPAPSNISAWWNFGSLLGICLLTQILTGLLLAMHYTADTTLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLYKETWNTGVILLLTLMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFMIAGLTLIHLTFLHESGSNNPLGIVSNCDKIPFHPYFTLKDILGFMLLLLPLTTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLVLFLAPFLHKAKQRAMTFRP...
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is...
O79226
Q985G2
CCME_RHILO
Heme chaperone CcmE
Mesorhizobium
MTRKQKRLSVIVGGLAFLGAATGLTFYALGQKASYFYMPADLTTASVQPGQRIRLGGLVEKGTIQRGQGATVAFSVTDTHKSVKVTYTGILPDLFREEQGVITEGSFGPDGVFVADSVLAKHDERYMPKEVADGLKAKGVWQESKSE
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
Q985G2
B8DZH3
CAS2_DICTD
CRISPR-associated endoribonuclease Cas2
Dictyoglomus
MYVIMVYDVNQRRINKVLNTARKYLEWIQNSVLEGEITEAKFEMLKREIEIIINEEEDSVIFYIMRTTKYSERQILGIEKNKREQIL
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic ac...
B8DZH3
Q6GQL0
CBLBA_XENLA
Signal transduction protein CBL-B-A
Xenopus
MASGSGSSSSTSSSALSGRLPGSRSANPRKARILGLFDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLIKKSKRAMRLFKEGKERMYEEQSQERRNLTKLSLIFSHMLAEIKAIFPSGQFQGDNFRITKADAAEFWRKFFGERTIVPWKIFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSLKPGSYIFRLSCTRLGQWAIGYVTADGNILQT...
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
Q6GQL0
Q5KV31
SECA2_GEOKA
Protein translocase subunit SecA 2
Geobacillus thermoleovorans group
MFAKVKQLFDESAREVQRLAKLAAQINEWEPTISSLSDEQLRQKTVVFKERLERGETLDDIKIEAFAVVREAARRVLGLRHYDVQLMGGLAMHEGNIAEMQTGEGKTLAATLPSYLHALLGKGVHIITANEYLARRDCEQMGRVFRFLGLTVGLNVSQMTASEKKEAYAADITYGTGTEFGFDYLRDNMVYRLEDKVQRPLYYAIIDEIDSILIDEARTPLIIANKSGIGAELFPIMARIVRTFEEGKEYERSLETKQIFLTEEGAQKIERAFGIDNLYDWEHHVLLHHAMQSLRAWFIMRRDVDYIVKNGKVMIVDPFT...
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains acro...
Q5KV31
Q93WN0
SEBP2_ARATH
Protein EMBRYO SAC DEVELOPMENT ARREST 38
Arabidopsis
MATETVLATAVSNGKSKGCCKSGPGYATPLAAMAGPREKLIYVTALYSGTGRDKPDYLATVDVDPSSPTFSSVIHRLKMPYIGDELHHTGWNSCSSCHGDASADRRYLVLPGLISGRIYAIDTKTDPKAPSLYKVVEPKEIAEKTGLAFPHTSHCLASGDMLVSCLGDKEGNAKGNGFLLLDSDFNVKSRWDKPGHGPLFGYDFWYQPRFKTMISTSWGAPKAFSKGFNLQHVADGLYGSHLHIYQWPEGEMKQIIDLGNTGLLPLEIRFLHDPSKDTGYVGSALSSNMIRFFKNSDDTWSHEVVISVKPLKVENWILPE...
Required for the fusion of female gametophyte polar nuclei.
Q93WN0
P29400
CO4A5_HUMAN
Collagen alpha-5(IV) chain
Homo
MKLRGVSLAAGLFLLALSLWGQPAEAAACYGCSPGSKCDCSGIKGEKGERGFPGLEGHPGLPGFPGPEGPPGPRGQKGDDGIPGPPGPKGIRGPPGLPGFPGTPGLPGMPGHDGAPGPQGIPGCNGTKGERGFPGSPGFPGLQGPPGPPGIPGMKGEPGSIIMSSLPGPKGNPGYPGPPGIQGLPGPTGIPGPIGPPGPPGLMGPPGPPGLPGPKGNMGLNFQGPKGEKGEQGLQGPPGPPGQISEQKRPIDVEFQKGDQGLPGDRGPPGPPGIRGPPGPPGGEKGEKGEQGEPGKRGKPGKDGENGQPGIPGLPGDPGY...
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
P29400
Q9ZK62
SRP54_HELPJ
Fifty-four homolog
Helicobacter
MFQALSDGFKNALNKIRFQDDEKALDRALDELKKTLLKNDVHHKVARELLKKVESQTKAGGIGKQQFLDALEKSLLEILSAKGSSGFTFAQTPPTVVLMAGLQGSGKTTTTAKLAHYLKTKNKKVLLCACDLQRLAAVEQLKVLGEQVGVEVFHEENKSVKEIANNALKRAKEAQFDVLIVDSAGRLAIDKELMQELKEVKEVLNPHEVLYVADALSGQDGVKSANTFNEEIGVSGVVLSKFDSDSKGGIALGITYQLGLPLRFIGSGEKIPDLDVFMPERIVGRLMGAGDIISLAEKTASVLNPNEAKDLSKKLKKGQF...
Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. I...
Q9ZK62
Q5WX94
HIS52_LEGPL
ImGP synthase subunit HisH 2
Legionella
MIAVIDVSGNNLTSLTNALIRLGGHFALTHDAQEIQKASHVILPGVGTARSGMTALQQNGLIDVLRTLTQPLLGICLGMQLLLEYSEEDDIPCLGLIPGVAELLKAERNHPVPHMGWNNLHWQKTSSLQQGLNNSDYVYFVHSYALKADDYALARCRYHEEFTAVVKKGNFYGMQFHPEKSADVGMVLLNNFLSLESKC
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.
Q5WX94
A1JJF2
APAH_YERE8
Diadenosine tetraphosphatase
Yersinia
MSTYLIGDVHGCLDELLALLAQVDFDPQHDTLWLTGDLVARGPASLDVLRYVRSLGPAVRMVLGNHDLHLLAVYAGISRNKPKDRITPLLEAPDADELINWLRRQPVLQVDDELKLIMAHAGITPQWDIETAQMCAREVESVLSSDSYPLFLDAMYGDMPNNWSPELTGLARLRFSTNALTRMRFCFPNGQLDMICKDTPENAPAPLKPWFELPRLVSPEYSIIFGHWASLEGKGVPEGIYGLDTGCCWGGNLTLLRWEDKRYFTQPAFKVEAEITNADEIAAAAKDPFSYL
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
A1JJF2
F4JP36
HAP2_ARATH
GENERATIVE CELL SPECIFIC 1
Arabidopsis
MVNAILMACILAGIFVGMFNEVDGIQILSKSKLEKCEKTSDSGNLNCSTKIVLNLAVPSGSSGGEASIVAEIVEVEDNSSSNMQTVRIPPVITVNKSAAYALYDLTYIRDVPYKPQEYHVTTRKCEHDAGPDIVQICERLRDEKGNVLEQTQPICCPCGPQRRMPSSCGDIFDKMIKGKANTAHCLRFPGDWFHVFGIGQRSLGFSVRVELKTGTRVSEVIIGPENRTATANDNFLKVNLIGDFGGYTSIPSFEDFYLVIPREAAEAGQPGSLGANYSMWMLLERVRFTLDGLECNKIGVGYEAFNTQPNFCSSPYWSCL...
Required for male fertility . Plays a role in pollen tube guidance and successful gamete attachment . Essential for the fusion of gametes during double fertilization, where one male gamete fuses with the egg to produce a zygote, and another male gamete fuses with the central cell to produce the endosperm . Mediates the...
F4JP36
Q64448
CXA3_MOUSE
Connexin-46
Mus
MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEVWGDEQSDFTCNTQQPGCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEELLRRDNPQHGRGREPMRTGSPRDPPLRDDRGKVRIAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFQLQPLYRCDRWPCPNTVDCFISRPTEKTIFVIFMLAVACASLVLNMLEIYHLGWKKLKQGVTNHFNPDASEARHKPLDPLPTATSSGPPSVSIGFPPYYTHPACPTVQAKAIGFPGAPLSPADFTVVTLNDAQGRNHPVKH...
Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore.
Q64448
Q6AF89
PYRR_LEIXX
Uracil phosphoribosyltransferase
Leifsonia
MVTRVVLQQADISRALTRISHEILESNRGIDGLAILGIPTRGVVLARRIAESIQRIEQEAVGASADIVGALDVTMYRDDLARNPTRAPQPTSLPGPIDGKTVVLVDDVLFSGRTIRAALDALSDLGRPRAVRLAVLVDRGHRELPIRADFVGKNLPSAASERIFVRFAEVDGQDAVTIEEGGA
Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
Q6AF89
B1MIT2
FGD_MYCA9
F420-dependent glucose-6-phosphate dehydrogenase
Mycobacteroides abscessus
MARELKLGYKASAEQFAPRELVELAVATESHGFDSATVSDHFQPWRYNGGHAPFSLAWMTAVGERTQRLQLGTSVLTPTFRYNPAVTAQAFATMGCLYPGRIFLGVGTGEALNEIATGYIGEWPEFKERFARLRESVRLMRELWTGERVDFEGEYYRTQGAAIYDVPEGGIPVYIAAGGAVVAKYAGRAGDGFICTSGKGEELYSGKLIPAVREGAALAERSFDDIDRMIEIKISYDPDPDKALENTRFWAPLSLTPEQKHSIHDPIEMERAADELPIEQVAKRWIVASDPDEAVEKVADYVGWGLNHLVFHAPGHDQKR...
Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria.
B1MIT2
O03169
ATP6_LATCH
F-ATPase protein 6
Latimeria
MSLNFFDQFMSPTLLGVPLIAVAMMFPWTLLPTPTNRWLNNRTLTLQNWFIGRFTNQLLQPLNTGGHKWAMILMSLNLLGLLPYTFTPTTQLSLNMGLAIPFWLATVLLGLRNQPTAALGHLLPEGTPTLLIPILIIIETISLLIRPFALGVRLTANLTAGHLLMQLIATAAFVLLPMMPTVALLTTLVLFLLTLLEIAVAMIQAYVFVLLLSLYLQENV
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous ca...
O03169
Q51782
PHNHY_PSEFL
Phosphonoacetate hydrolase
Pseudomonas
MTQLISVNSRSYRLSSAPTIVICVDGCEQEYINQAIQAGQAPFLAELTGFGTVLTGDCVVPSFTNPNNLSIVTGAPPSVHGICGNFFFDQETQEEVLMNDAKYLRAPTILAEMAKAGQLVAVVTAKDKLRNLLGHQLKGICFSAEKADQVNLEEHGVENILARVGMPVPSVYSADLSEFVFAAGLSLLTNERPDFMYLSTTDYVQHKHAPGTPEANAFYAMMDSYFKRYHEQGAIVAITADHGMNAKTDAIGRPNILFLQDLLDAQYGAQRTRVLLPITDPYVVHHGALGSYATVYLRDAVPQRDAIDFLAGIAGVEAVL...
Specifically hydrolyzes phosphonoacetate. Does not have activity on other organophosphonates or acetates.
Q51782