accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q91577
CY561_XENLA
Cytochrome b561
Xenopus
MENALSSQNLGFMPYLVAGSQILGIANLAITGAWLAQLQRRFLWSGPLQFNVHPLCMVLGMVFLCGEALLVYRVFRHETKRSTKILHGVLHIMALVISLVGVIAVFQYHQANGYPDMYSLHSWCGIVTFTLYILQWIIGFSLFFIPGVAFTYRSQFKPLHEFFGRALFLSSIATSLLGLTEKMFSEYSSHPAEGILVNSLGVLLVVFGAVIAYILTREDWRRPPLPEEQALSMDFKTLTEGDSPTDQ
Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce monodehydro-L-ascorbate radical in the lumen of secretory vesicles. It is therefore involved the regeneration and homeostasis within secretory vesicles of ascorbate which in turn provides...
Q91577
P0A213
SBMC_SALTI
DNA gyrase inhibitor
Salmonella
MDYEIRQEQKRKIAGFHMVGPWEHTVKQGFEQLMTWVDRQRIVPVEWIAVYYDNPDVVPAEKLRCDTVVSVAENFILPDNSEGVIVTAIEGGEYATAVARVEDRDFAKPWERFFDVLEQDSAYQIASAPCFETYLNNGMEDGYWDIEMYIPVQRK
Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the ce...
P0A213
B3GZ78
RPOZ_ACTP7
Transcriptase subunit omega
Actinobacillus
MARVTVQEAADKIGNRFDLILTAARRARQLQLHAREPLVPEENDKPTVIALREIEKGLINGQIMDQLENNDAIQQEVAEQEAISFLADVQANA
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
B3GZ78
B7HMX7
METE_BACC7
Methionine synthase, vitamin-B12 independent isozyme
Bacillus cereus group
MAIQTSNLGYPRIGLQREWKKTLEAFWSNKIDEEQFLTTMKEIRLKHVKAQQEKGIELIPIGDFTYYDHVLDTAYMLGFIPSRFSEFTSYLDVYFAMARGSKDHVASEMTKWFNTNYHYIVPEYEEGLQISLKDNRPLRLYEEAKQELGVDGKPVILGPYTFLKLAKGYTQEQFATILKQLVAPYVQLLSELHAAGAQIIQVDEPIFASLTKEEVQQAKEIYEAIRKEVPNANLLLQTYFDSVEENYEEIITFPVSSIGLDFIHGKEGNLHAISKYGFPADKTLAVGCIDGRNIWRADLDEVLTLFTTLQKQVQTKNFIV...
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
B7HMX7
P09413
GVPC_DOLFA
Gas vesicle protein C
Dolichospermum
MISLMAKIRQEHQSIAEKVAELSLETREFLSVTTAKRQEQAEKQAQELQAFYKDLQETSQQFLSETAQARIAQAEKQAQELLAFHKELQETSQQFLSATAQARIAQAEKQAQELLAFYQEVRETSQQFLSATAQARIAQAEKQAQELLAFHKELQETSQQFLSATADARTAQAKEQKESLLKFRQDLFVSIFG
May confer stability to the gas vesicle membranes. Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth.
P09413
P18311
IF2_ENTFC
Translation initiation factor IF-2
Enterococcus
MSNKRIYELAKELNQPSKDVVEKAQQLGINVKNHMGTITTGDEKKLQQAFKKPQTNKKPAQQASQKPATNQPNEQKKQETKTKQQKNNRNYQDRGQGSGQVNQGKNQSTNQNRSNNGGGNNQNRQGATQSGNQNRQGSTQGGNQNRQGSNQGGNQNRNNNNNRGKFNNNNRNRFNKKGKKGKQQTSNKPAVPPRKFRELPEVLEYTEGMNVADIAKKIHREPAEIIKKLFMLGVMVNQNQALDKDTIELLATDYGMEPQEKIQVDIADIDKFFEPEELNPDTLVSRPPVVTIMGHVDHGKTTLLDTLRHSRVTSGEAGGI...
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
P18311
Q8RP17
HOPW1_PSEYM
Type III effector hopPmaA
Pseudomonas
MSPAQIIRTPHSFPPSFTGTSSSAENSHAQSPQQVLTRAFVASGELNAAFGRTSTASEQDFTSLLGTLQRELERKTLSFPDIAELANQLAEAAKGDQGGHWLGRDEQQTLKGMIDRCKSQLAHTHASDASYDPLAQVCENLKTARLHQSISQMTGEAHAKVRGVPDLLALIQLDPDVLAEKPVGMTSYVNFGSFICMAKARTAELSEDLRSDPNEVALLLHPHADTILELERLPDALAALTENCPDTPTRDDLRSLAKETGELLQQLRANDLLPRSEEVSSYQGETSVRSREVVEPKLTLCQAGGNGQGQLEASSARPES...
Induces hypersensitive response (HR).
Q8RP17
P44094
DEND_HAEIN
D-erythronate dehydrogenase
Haemophilus
MKVVITGGQGFLGQRLAKTLLAQNNVHIDDLILIDVVKPIAPNNDPRVRCYEMNLRYPTGLDELITEETDAIFHLAAIVSSHAEQDPDLGYETNFLATRNILEICRKNNPKVRFIFSSSLAIFGGELPETILDSTAFTPQSTYGTQKAMCELLINDYSRKGFVDGIVVRLPTICIRPGKPNKAASSFVSSIMREPLHGEDAVCPVSEELRLWLSSPNTVVANFIHALQLPSLPLRSWHTINLPGFSVTVKQMLSDLTQVKGEAILEHIKFEFDESINNIVASWPSRIDNTQALALGFKVDSNFQNVIQQFIEYDM
Catalyzes oxidation of D-erythronate to 2-oxo-tetronate. Can use either NAD(+) or NADP(+) as cosubstrate, with a preference for NAD(+).
P44094
B3LHC6
GEP7_YEAS1
Genetic interactor of prohibitin 7, mitochondrial
Saccharomyces
MVLSNVKIFRLKSHRAFRIGPMIKAVAGNLLVKRFYQPKLERIPPASLLLKQKIRLAQNGSTTSTENPISFSQTMSEIFSVLQPSAPDLDEDETSGLKRDHLLTERLNNGELGVIMNKFFNPSSTHNNQLIDTNILLQNFPKLSGNDLDLLDFAINEKMRGNWNDLKQDFIQLWYYKSFGFLGPRTQFVLTNSSPSLRSQFLKLPFIEYNWFLLQNNKNANILPADVQNVVKVFHLDDKRFSWKSIDPFSKAIISFVVFVSIYVWLDESAKQKTKELPAQKSTVISE
Involved in respiratory growth and required for cell survival in the absence of prohibitins or GEM1.
B3LHC6
A9WK05
GREA_CHLAA
Transcript cleavage factor GreA
Chloroflexus
MTEKPTYLTREGRARLEAELEYLTTVERKQIAERIAAAKELGDISESGEYEDAKKAQALLEGRIRELKHLLSRAEVIDEDQASNGEVRVGSSVTVRFEDDGTEETWTIVGSAEANPRQGRISNESPLGAALLGKRARNKVTVHTPSGVMKLTILKVR
Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factor...
A9WK05
A1TC97
IOLG2_MYCVP
Myo-inositol 2-dehydrogenase 2
Mycolicibacterium
MSELRVAVLGVGVMGADHVARITSRISGARVSVVNDYVTEKAEQIASEVDGCRAVVDPLDAIADPEVDAVVLATPGSTHEKQLLACLDHRKPVMCEKPLTTDVFTSLEIARREAELECPLIQVGFMRRFDDEYMRLKALLDGGELGQPLVMHCVHRNPGVPSYFDSSLIVKDSLVHEVDVTRYLFGEEIASVQIVRPVSNPAAPEGVIDPQIAILRTVSGRHVDVELFVTTGVAYEVRTEVVGERGSAMIGLDVGLIRKSAPGTWGGLIAPGFRERFGRAYDTEIQRWVDAVRAGTNIDGPTAWDGYAAAAVCAAGVESL...
Involved in the oxidation of myo-inositol (MI) to 2-keto-myo-inositol (2KMI or 2-inosose).
A1TC97
B1HZ48
PEPT_LYSSC
Tripeptide aminopeptidase
Lysinibacillus
MKEQVIERLIRYAKIDTQSDFTSETTPSTPKQFDLLHVLKDELATIGLTDITLDENGYLFATLEANTDKDVPTIGFLAHVDTTTDFTGTNVNPQRLDNYDGGDIQLNENLVMSPADFPELQNYIGQTLITTDGTTLLGADDKAGIAEIITAMEYLIQNPSIKHGKLRVAFTPDEEIGRGPHKFDVAAFGADYAYTMDGGPLGELQYESFNAAGVKVITKGTSVHPGSAKNKMVNAITMAIAFQNEMPTEAVPEKTEGYEGFIHLMGFKGAIEHAELSYIVRDHDRQKFEEKKQLMQAAAAKIQAQFGEDALSITIEDQYY...
Cleaves the N-terminal amino acid of tripeptides.
B1HZ48
B4TWQ6
DAPB_SALSV
4-hydroxy-tetrahydrodipicolinate reductase
Salmonella
MHEAQIRVAIVGAGGRMGRQLIQAAMAMEGVQLGAALEREGSSLLGSDAGELAGVGKTGVIIQSDLASVKDDFDVLVDFTRPEGTLAHLAFCRKHGKGMVIGTTGFDDAGKQAIREASQEIAIVFAANFSVGVNVMLKLLEKAAKVMGDYTDIEIIEAHHRHKVDAPSGTALAMGEAIAGALDKDLKDCAVYSREGYTGERVPGTIGFATVRAGDIVGEHTAMFADIGERVEITHKASSRMTFANGALRSALWLKTKKNGLFDMRDVLGLDVL
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
B4TWQ6
O14633
LCE2B_HUMAN
Small proline-rich-like epidermal differentiation complex protein 1B
Homo
MSCQQNQQQCQPPPKCPPKCTPKCPPKCPPKCLPQCPAPCSPAVSSCCGPISGGCCGPSSGGCCNSGAGGCCLSHHRPRLFHRRRHQSPDCCESEPSGGSGCCHSSGGCC
Precursors of the cornified envelope of the stratum corneum.
O14633
Q9SSB4
PRS7B_ARATH
Regulatory particle triple-A ATPase subunit 1b
Arabidopsis
MIIRDIMEDPENEGPHNMRSDFEPLLSVLRLRDYETGDIIEFDSTEASEEALSDITEFGSTEASEAHFEEPYSARIKKVEKEINELAEKICNLGIKESDTGLAPPNQWDLVSDKQMMQEEQPLLVATCTQIISPNTEDAKYVVDIKKIGKYVVGLGDKASPTDIEAGMRVGVDQKKYQIQIPLPPKIDPSVTMMTVEEKPDATYSDIGGCKEQIEKIREVVELPMLHPEKFVRLGIDPPKGVLCYGPPGSGKTLVARAVANRTGACFIRVVGSELVQKYIGEGARMVRELFQMARSKKACILFFDEIDAIGGARFDDGVG...
The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
Q9SSB4
B5FHG5
CAIC_SALDC
Crotonobetaine/carnitine--CoA ligase
Salmonella
MDIVGGQNLRQMWDDLAGVYGDKTALIFESCEGIVRQFSYASLNEEINRTANLFYSLGIRKGDRVALHLDNCPEFIFCWFGLAKIGAIMVPINARLLGEESAWILQNSQVSLLVTSAQFYPMYREIRQDNSTPLNHICLIGEQLPADDGVSHFSQLQARQSATLCYTPVLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQIALRDDDVYMTVMPAFHIDCQCTAAMPAFSAGSTFVLLEKYSARAFWDQVRKYQATVTECIPMMIRTLMVQPAAPTDRQHHLREVMFYLNLSAQEKDAFTERFGVRLLTSYG...
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.
B5FHG5
C8VG90
ACON_EMENI
Homocitrate dehydratase
Aspergillus subgen. Nidulantes
MITTRLARMGALAPKSRLLFGTRGMATVADLDKKVEMCNLEKGNYINYKKMSENLDVVRRRLTRPLTYAEKILYSHLDDPQNQDIERGKSYLKLRPDRVACQDATAQMAILQFMSAGMPSVATPTTVHCDHLIEAQLGGEKDLARANEINKEVYDFLASSTAKYNIGFWKPGSGIIHQIILENYAFPGGLMIGTDSHTPNAGGLAIAAIGVGGADAVDVMAGLPWELKAPKVIGVRLTGEMSGWTAPKDIILKVAGLLTVKGGTGAIIEYHGPGVNSLSATGMATICNMGAEIGATTSLFPFNDRMYDYLKATKRQQIGD...
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate, a step in the citric acid cycle. Also catalyzes the reversible dehydration of (R)-homocitrate to cis-homoaconitate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.
C8VG90
Q2YXY7
NIKB_STAAB
Nickel import system permease protein NikB
Staphylococcus
MFIIKSMLYRLMQMIVVLFVISTLTFILMKLSPGNPVDKILHLDVAQVSMEQINATKDKLGLNDSLLVQWWHWMNHLLHFNLGKSFESKEPVTQILFNYAPITLLISFSTLVLSLCISIPLGIIAAKRFHKLSDKVIRVISTLSISLPAFFIGIILLFIVTNLMNIDSVILSQFILPVITLSLGMCAYIIRLVRSNLLMLLQSNIVQASRLRGMNERYILIHDLLKPTILPIIPLLGISLGSLIGGTVVIENLFDIPGIGYLLMDSIKSRDYPVIQGCVLFIGFFVVIINTIADLLTLLLDPKQRLQLGNPKSKANTPLI...
Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import. Probably responsible for the translocation of the substrate across the membrane.
Q2YXY7
Q22024
EGL43_CAEEL
Egg-laying defective protein 43
Caenorhabditis
MSIDTDFLTSVEVKEDELHGNVLIAVTQIALGRTIGVIDKATPNDSNALLILNLIKEADDGEDANICMRQEDRKTFLQTSKIINIGERLLLQRLSEEECDEEDQDDLENLILLKDEDRPDSTQSCTKSSSEDSNLNGFEEYIREHGELVPGQTPPDGSHKCGVCPKSFSSASGLKQHSHIHCSLKPFRCHLCPKSYTQFSNLCRHRRVHSDGWTCPTCQSQMPSQAALTKHRPVCEMTALYKPLMAQLAGLSGAGGLGSVPYWPHILQMATQAPHFPLAFLAANPEAYKLMQQTTCASPDAECSSGHASESSPTTTEPVD...
Dispensable for anchor cell (AC) invasion and for preventing AC proliferation.
Q22024
O26129
RL19E_METTH
50S ribosomal protein L19e
Methanothermobacter
MNLTTQKRLAADILKVGVNRIWIDPERIDEVSRAITRDGVKQLIKDGAIKAKPKKGISSYRSKKIAQQKKKGRRRGPGSIKGAKGARRPKKDEWMTTIRALRKDLKEMRDNREINKSTYRKLYKMAKGGAFKSKSYMKTYARDHDMLR
Binds to the 23S rRNA.
O26129
P70612
CXCR1_RAT
High affinity interleukin-8 receptor A
Rattus
MAEAEYFIWIAPEGDFEEEFGNITRMLPTGEYFSPCKRVPMTNRQAVVVFYALVFLLSLLGNSLVMLVILYRRRTRSVTDVYVLNLAIADLLFSLTLPFLAVSKWKGWIFGTPLCKMVSLLKEVNFFSGILLLACISVDRYLAIVHATRTLTRKRYLVKFVCMGTWGLSLVLSLPFAIFRQAYKPYRSGTVCYEVLGEATADLRITLRGLSHIFGFLLPLFIMLVCYGLTLRTLFKAHMRQKRRAMWVIFAVVLVFLLCCLPYNLVLLSDTLLGAHLIQDTCERRNNIDQALYITEILGFSHSCLNPVIYAFVGQSFRHE...
Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
P70612
B6IZM3
NDK_COXB2
Nucleoside-2-P kinase
Coxiella
MAIERTLSIIKPDAVAKNVIGQIYSRFEKAGLKIIAAKMCHLSKPQAEKFYAVHKDRPFYPDLVKFMTQGPVMIQVLEGENAIVKNREIMGATNPKEALPGTIRADFADSIDANAVHGSDGPETAKEEIAFFFKPDESFNSIGV
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
B6IZM3
A0A348AXX6
TR03_CURCL
KK-1 biosynthesis cluster protein TR03
Curvularia
MALQERRAAVTSSDILSAHAISSPALAAAAINFAASFHRDARTCCSAHERSQLQKVYRDKILANDKFTANIAAAFLSVLGPNAGRNDAGAERERWGDFDRLAQRGKNMRDRESQHLQHQSGIIAAWGPRCFEYYGWHVLPLPLLRQVHDLAVLIPSWDDAVELLNSRMLLRHELRVLHGNNKALRIGEHSAASKVQDSRSPVERTDIVAALDWARANATSAAARQAVKEAAQGMNGTPINTFGLKRDCYGMVVPSVGPYDPDGDDDNDEDVVDVSPRPAKHIKLSAAEPLRLMFPGSLSHVQACQRHDTDGEKASTAPIR...
Part of the gene cluster that mediates the biosynthesis of KK-1, a novel cyclic decapeptide compound with potent antifungal activity . The nonribosomal peptide synthetase (NRPS) catalyzes the elongation and cyclization of the decapeptide chain composed of 1 pipecolic acid residue (Pip), 1 alanine residue (Ala), 1 aspar...
A0A348AXX6
Q9UT35
GDA1_SCHPO
Guanosine-diphosphatase
Schizosaccharomyces
MTPTMKSIARRKALLIALSIFAVTFILWNGFPGSSNRPLPSSNDEFHYEDIELPSGYRSEGEVVDLLNPKDELEEPLFSEEPLFPVTTSIPTKTAVSKPKIAPTSAAKDVTFSSSIDSDDCSVAYDNSKPVRQYVLMIDAGSTGSRVHVYQFNNCNPSPKLEEEFFKMIEPGLSSFAGDPEGAAASLDPLLDYAMENVPEEYRRCSPIAVKATAGLRLTGESEAKAILKSVRQHLENDYPFPIVKDGVSILEGSMEGIYAWITINYLLGTLGGKATHSTVAVMDLGGASTQLVFEPRFASDGESLVDGDHKYVLDYNGEQ...
After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.
Q9UT35
B0KSA9
LPXD_PSEPG
UDP-3-O-acylglucosamine N-acyltransferase
Pseudomonas
MSVTMTLGQLAEALGATLKGPEALQITGLATLQEAGPGQLSFLANPQYRKYLDNCQAGAVLLKAADAESFAGNALIVADPYQAYARISHLFDPKPKAVAGIHPSAVVAEDAQVDASASIGPFAVIESGARIEADVSIGAHCFVGARCVVGEGGWLAPRVTLYHDVTIGKRVVIQSGAVIGGEGFGFANEKGIWRKIAQIGGVTIGDDVEIGVNTAVDRGALSDTRIGDGVKLDNQIQIAHNVQIGDHTAMAACVGISGSTRIGKHCMLAGGVGLVGHIDICDNVFVSGMTMVTRSITEPGSYSSGTAMQPLADWRKSAAR...
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
B0KSA9
B1HQB9
PYRC_LYSSC
Dihydroorotase
Lysinibacillus
MKKVLRNVQMLNEQGELQTVNIAMADGKITAIGQEVTVVNAEVIEGNGLIVAPGFVDVHTHLREPGFEHKETIATGSASAAKGGFTTICAMPNTKPVPDSVENMQLINGLIKESAVIRVLPYGSLTKDISGEVRTNVEELKAYGAVAFSDDGVGIQLASTMYEQMKDAAKHDMVVVAHCEDNSLIYDGVMHEGKRNKELDLPGIPSICESVQIARDVLLAEAAGARYHVCHVSTKESVRAVRDAKAAGIRVTAEVCPHHLLLEEMDIPSDDANWKMNPPLRGADDKDSLHAALLDGTIDCIATDHAPHTVEEKCCGMVGA...
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
B1HQB9
Q73K68
FLIW_TREDE
Flagellar assembly factor FliW
Treponema
MEIKTKAMGLVEIQDEQIIELVDGFYGFEEFHKYALLDSGKEPFFWVQSLDDQNLAFIVIDPFLFRPDYELDIDDELLKPIEAESPKDLLVFALVTIPPAGSPITANLQGPLIINKKNKKAFQAVLNDGKWNTKHDILAELNAAGRN
Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.
Q73K68
Q9VKD6
DGT2_DROME
Dim gamma-tubulin 2
Sophophora
MDDPSATLLPEHSEDLRLARDAELKKVLKLKLVLDELRRLDVGPNPSDEIKRALKLVSIGSYARLGEMEGAGQEQVLGLPSGSSFPPLNYTDRKTVRTKLSAQLRTTLQPIAELCDRIREEFPDAFGQEADLSCDQKEILRLEEEHRSGLEKLVALLTRKCTLLKETAELKLGPQLANELKLQQAQAQLVQTKAELLRGFFVHEAASRTEHSVKAHKEVEAHLDELLAAKK
As part of the augmin complex, plays a role in centrosome-independent generation of spindle microtubules . The complex is required for mitotic spindle assembly through its involvement in localizing gamma-tubulin to spindle microtubules . dgt2 binds to microtubules in vitro .
Q9VKD6
A4W0P5
THII_STRS2
tRNA 4-thiouridine synthase
Streptococcus
MNYSEIMIRYGELSTKGKNKMRFVNKLRNNIKHVLSVYPEVTVYFDRDRGHVYLNGADYQEVSASLKKIFGIQNFAPSYKIEKSVPALKEAVVEIMQTIYKEGMTFKIAARRSDHSFELDSRDLNQVLGDAVFTAIPNVQVQMKSPDITLRVEIRPDAAYISHEEIKGAGGLPVGTSGKGTLMLSGGIDSPVAGYLALKRGVEIEALHFASPPYTSPGALKKAHDLTRKLTAFGGNITFIEVPFTEIQEEIKEKAPEAYLMTLTRRFMMRITDRVREERGAMVIINGESLGQVASQTLESMQAINAVTNTPVIRPVVTMD...
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynt...
A4W0P5
B9MLZ0
CH10_CALBD
Chaperonin-10
Caldicellulosiruptor
MKIRPIGDRILIKFKEREEVTKSGIVLPDTVKEKPQIAEVIEVGPGGIVDGEKVEMVVKKGDKVIVSKYAGTEIKIDGEEYTIIRQDDVLAIIED
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of ...
B9MLZ0
A7EHM8
EIF3B_SCLS1
Translation initiation factor eIF3, p90 subunit homolog
Sclerotinia
MAPSFDHLPDPEEDEYDEEELDISDLRERFEVQLEQGLDTFVVIDGLPEVNEDTKPKLIKFLLRKLDSVGQTKKDSIHMPIGPDGKSFKFAFVEYSSPAEAIAACKALDGVPLDKKHTLRVNKLTDIDRYGREGRIDENYTPPKIEEFTEKEHLRSWLADPAGRGRDQFVMYKDDRVQVFWNNEKDAPESIVDRQHWTESFVQWSPQGTFLTSMHQQGVQLWGGPSWTRQKRFAHPFVNLVDFSPGEKYLTTWSNRPISIGEEGHPALSVDDDGKNYVIWDIETGLPLRSFANLDLPSNSVDAEGNPVKRKIQWPAFKWS...
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and...
A7EHM8
Q7RTV3
ZN367_HUMAN
C2H2 zinc finger protein ZFF29
Homo
MIRGFEAPMAENPPPPPPPVIFCHDSPKRVLVSVIRTTPIKPTCGGGGEPEPPPPLIPTSPGFSDFMVYPWRWGENAHNVTLSPGAAGAAASAALPAAAAAEHSGLRGRGAPPPAASASAAASGGEDEEEASSPDSGHLKDGIRRGRPRADTVRDLINEGEHSSSRIRCNICNRVFPREKSLQAHKRTHTGERPYLCDYPDCGKAFVQSGQLKTHQRLHTGEKPFVCSENGCLSRFTHANRHCPKHPYARLKREEPTDTLSKHQAADNKAAAEWLARYWEMREQRTPTLKGKLVQKADQEQQDPLEYLQSDEEDDEKRGA...
Transcriptional activator. Isoform 1 may be involved in transcriptional activation of erythroid genes.
Q7RTV3
Q7ZUV2
KTNB1_DANRE
p80 katanin
Danio
MALTNTTITSWKLQEIVAHSSNVSSLVLGKSSGRLLATGGEDCRVNIWAVSKPNCIMSLTGHTSAVGCIQFNSSEERVVAGSLSGSLRLWDLEAAKILRTLMGHKASISSLDFHPMGEYLASGSVDSNIKLWDVRRKGCVFRYKGHTQAVRCLAFSPDGKWLASASDDSTVKLWDLIAGKMITEFTSHTSAVNVVQFHPNEYLLASGSADRTVKLWDLEKFNMIGSSEGETGVVRSVLFNPDGSCLYSGSENTLRVYGWEPDRCFDVVHVGWGKVSDLAISNNQMIAVSYSHTNVSWYVVDLNRVKKSGSVIQGLIQDKP...
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome foll...
Q7ZUV2
P22515
UBA1_YEAST
Ubiquitin-activating enzyme E1 1
Saccharomyces
MSSNNSGLSAAGEIDESLYSRQLYVLGKEAMLKMQTSNVLILGLKGLGVEIAKNVVLAGVKSMTVFDPEPVQLADLSTQFFLTEKDIGQKRGDVTRAKLAELNAYVPVNVLDSLDDVTQLSQFQVVVATDTVSLEDKVKINEFCHSSGIRFISSETRGLFGNTFVDLGDEFTVLDPTGEEPRTGMVSDIEPDGTVTMLDDNRHGLEDGNFVRFSEVEGLDKLNDGTLFKVEVLGPFAFRIGSVKEYGEYKKGGIFTEVKVPRKISFKSLKQQLSNPEFVFSDFAKFDRAAQLHLGFQALHQFAVRHNGELPRTMNDEDAN...
Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E...
P22515
Q9UTR6
OCH1_SCHPO
Initiation-specific alpha-1,6-mannosyltransferase
Schizosaccharomyces
MLRLRLRSIVIGAAIAGSILLLFNHGSIEGMEDLTEISMLEDYTPEAANKDYVGQQEEEELLYDQPSYIEEEEDPDLEAYLSDLEREELEHSLEELDEENNYKLHLRYSFSQLQDFDEENEAVHMIVPKDTYEFEVPYHADIPKLIWQTSKDPFDREVMKYTRFWRINHPSYSHAVLDDEQSKALVISSFGDSSVSKISQAYAMMPLPVLKADFFRYLVLLAKGGIYSDIDTAPLKHINNWIPREYRKRNIRLIVGIEADPDRPDWNDYYARRVQFCQWTIAAAPGHPILWELVRRITDETWKLHDSKKLSKNGESVMEW...
Mannosyltransferase involved in outer chain elongation of asparagine-linked oligosaccharides of the type Man(9)GlcNAc(2). May otherwise add the first alpha-1,6-mannose to the Man(8)GlcNAc(2) core oligosaccharide from the ER. Represents the first enzymatic event required for synthesis of outer chain mannose linkages on ...
Q9UTR6
B8F6M3
RSMJ_GLAP5
rRNA (guanine-N(2)-)-methyltransferase
Glaesserella
MNIQLINESDFTERFYDICEKWKLKHNPSSNLALVQTNERLELRKLNQPKLGAVAVNFVDGKMSYRRKFGGGRNEAIVKAVGVKGSYTPTIIDATAGLGQDAFVLASIGCYVKLIERNPIVGALLEDGLQRAYKDLEIGHFMRERMVLLPHSSITGLNPDLDSVDVVYLDPMYPSKTKSALVKKEMQLFQQLVGCDLDSDDLLFPAQQLARKRVVVKRPNYALFLANKKPDFCKETKKHRFDIYLSH
Specifically methylates the guanosine in position 1516 of 16S rRNA.
B8F6M3
P50183
T2N4_NEILA
Type-2 restriction enzyme NlaIV
Neisseria
MIKLTAQQIFDKLLDEEKILSANGQIRFFLGDVDIIVKQKDVVGNIIQEWLGGWLRKREIEFDVSTNTQMPPDFFLNKKDRSRELLEVKAFNRNASPGFDIADFKMYSDEIIHKPYMLDVDYLIFGYDMDDNGNVTIKDLWLKKVWQITRSMDGWAINLQVKKGVVHKIRPGVWYSINKKNMPMFECLEDFVSAIEETVYQNPATRHNASLWKRKFEEAYKKHYNRSISIPRWHEIAHKYKKK
A P subtype restriction enzyme that recognizes the double-stranded sequence 5'-GGNNCC-3' and cleaves after N-3.
P50183
P06603
TBA1_DROME
Tubulin alpha-1 chain
Sophophora
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTVGGGDDSFNTFFSETGAGKHVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCMLYR...
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-...
P06603
Q9AT72
FAD2_CALOF
Delta(12) fatty acid desaturase FAD2
Calendula
MGAGGRMQDPTNGGNKTEPEPIQRVPHEKPPFTVGDIKKAIPPHCFNRSVIRSFSYVFYDLTIASILYYIANNYISTLPSPLAYVAWPVYWAVQGCVLTGVWVIAHECGHHAFSDHQWLDDTVGLVLHSFLLVPYFSWKYSHRRHHSNTGSIEHDEVFVPKLKSGVRSTARYLNNPPGRILTLLVTLTLGWPLYLTFNVSGRYYDRFACHFDPNSPIYSKRERAQIFISDAGILAVVFVLFRLAMTKGLTWVLTMYGGPLLVVNGFLVLITFLQHTHPSLPHYDSTEWDWLRGALTTIDRDYGILNKVFHNITDTHVAHH...
Catalyzes the desaturation of oleic acid to linoleic acid. Introduces a double bond at position 12 of 16:1(9Z) and 18:1(9Z).
Q9AT72
Q9MB58
F26_ARATH
Fructose-2,6-bisphosphatase
Arabidopsis
MGSGASKNTEEDDDGSNGGGGQLYVSLKMENSKVEGELTPHVYGSLPLIGSWDPSKALPMQRESALMSELSFVVPPDHETLDFKFLLKPKNRNTPCIVEEGENRLLTGGSLQGDARLALFRLEGDVIVEFRVFINADRVSPIDLATSWRAYRENLQPSTVRGIPDVSINPDPKSAECPLESLELDLAHYEVPAPAPSANSYLVYAADNAENPRSLSASGSFRNDSTPKAAQRNSEDSGVTVDGSPSAKEMTIVVPDSSNIYSAFGEAESKSVETLSPFQQKDGQKGLFVDRGVGSPRLVKSLSASSFLIDTKQIKNSMPA...
Synthesis and degradation of fructose 2,6-bisphosphate. Regulates carbon partitioning between sucrose versus starch during the diurnal cycle.
Q9MB58
Q1LM81
YCIB_CUPMC
Inner membrane-spanning protein YciB
Cupriavidus
MKFLFDLFPVILFFVAFKLFGIYPATAVAIGATVVQIAWVHFRHGKAEPMQWVSLAIIAVFGGATILLHNETFIKWKPTVLYWLFAVTLIGSVIGWRKNLIRAMMEKQVTLPEPMWGRLNVAWAGFFAVMGVLNLYVAYQFSTDTWVNFKLFGSMGLMLVFIVAQSIWLSRHIQETPSE
Plays a role in cell envelope biogenesis, maintenance of cell envelope integrity and membrane homeostasis.
Q1LM81
Q6M1B0
DHQS_METMP
3-dehydroquinate synthase II
Methanococcus
MKFGWIKTTGNDLEERMESVKDALESSIPGIIAEKEEISSVRELGNIKIVSDNLDADVVLINKGEDLEILKSAKLSGKETGVYVVINTKEDEVYATDVSKLDFVDYVVLEGSDWTIIPLENIIADLFSEEIKIVSVVTNVKDAEAAYEILEKGVDGVVLIPKDINEVKDFSKLIERMNSESVKLDYATVTKIEPVGSGDRVCIDTCSMMEMGEGMLIGSYSRGMFLVHSETVENPYVATRPFRVNAGPVHAYILCPENKTKYLSDLKAGDKVLVVNKNGETREAIIGRVKIEKRPLFLVEAEYNGENLRTILQNAETIRL...
Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3-dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis.
Q6M1B0
Q3TXU5
DHYS_MOUSE
Deoxyhypusine synthase
Mus
MEGTPPGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLDAYRTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHADLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRESGINRIGNLLVPNDNYCKFEDWLMPILDQMVLEQNTEGVKWTPSKMISRLGKEINNPDSVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKRSGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGAR...
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modific...
Q3TXU5
Q8EAE2
Y3964_SHEON
Nucleotide-binding protein SO_3964
Shewanella
MKLVIVSGRSGSGKSVALRVLEDLGYYCVDNLPLPLIGSLLEQLKGSNDLVAISVDVRNLPEQDKVLVKQLASLPEGTELTSFFLNSSDKVLLKRYSETRRLHPLSKSRVSLQEAIKLEGKLLEPLSQQMDHYIDTSNLNIYELSDQVRQILLGSVDKELVINFESFGFKHGMPTEADFMFDVRFLPNPHWEPELRPLTGLDEPVAEFLNRQPLVNKFIWQIENLLETWLPHLERNNRSYLTIAIGCTGGQHRSVYVAEQLAKRFSNGKHKVNARHRELSHAKA
Displays ATPase and GTPase activities.
Q8EAE2
Q9RTK2
DCDA_DEIRA
Diaminopimelate decarboxylase
Deinococcus
MSLSRHALQDAAQRFGTPLYLYDAEELDAALWRVQRAFGDARIFYAMKANPNLNLLRRYAAAGVGFECVSLGELLRAEAAGAGGERMILNGPAKSDAEYAAAARLGATIVVDREEEVVLLPPGSRVLVRVNPAMTVSTHEHLATGTARSKFGLTPEQVPGTLAELRDAGHEVLGLHMHIGSAIEQAEDFTAAFARVTELRAHIGGLSVLNVGGGWSLNADLEGIAYEAHEAARVFGAELWVEPGRYLVASAGWLLTRVVGTKRTGRNFCLVDAGMTEFLRPMLYGASHPLYPMWDALATEVWDVAGPACESGDLIARGVP...
Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine.
Q9RTK2
Q9QZT4
PA2GF_MOUSE
Phosphatidylcholine 2-acylhydrolase 2F
Mus
MKKFFAIAVLAGSVVTTAHSSLLNLKSMVEAITHRNSILSFVGYGCYCGLGGRGHPMDEVDWCCHAHDCCYEKLFEQGCRPYVDHYDHRIENGTMIVCTELNETECDKQTCECDKSLTLCLKDHPYRNKYRGYFNVYCQGPTPNCSIYDPYPEEVTCGHGLPATPVST
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids . Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidyl...
Q9QZT4
Q5QUC3
ISPD_IDILO
MEP cytidylyltransferase
Idiomarina
MKSESESHAQSQIDSLMAVIPAAGSGSRMQANIPKQFLMVANRTLLEYSIEAVLKDARVEQVFVAVSDSNAEYLIELKKSLPTKVHFVTGGNSRAESVLAGVKVAVSQGATHVLVHDAARPCLPKKALTAVINTGLKDPQGAILAIPVRDSLKRAVISVNDETGVTHIESSVDREALWQAQTPQVFNAERLQQAIEHMGALNPQLTDEASAMQWCGFQPALIPGSIRNLKVTHPEDFECVRDWLLADNNDHKN
Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
Q5QUC3
Q8EBR5
SURE_SHEON
Nucleoside 5'-monophosphate phosphohydrolase
Shewanella
MMRILVSNDDGVNAPGIKALTEALAEIATVMTVAPDRNCSGASNSLTLTNPLRINRLDNGYISVHGTPTDCVHLAIRELCDGEPDMVVSGINAGANMGDDTLYSGTVAAAMEGRFLGFPAVAISLNGKAFKHYHTAAVYARRIVQGLLAHPIASDQILNINVPDLPLDEIKGISVTRLGARHKAEGIVRTQDPAGREIFWLGPPGLEQDASEGTDFHAIAHGYVSITPLTVDLTAYRQLSILQNWVDKI
Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.
Q8EBR5
Q6A651
PDRP_CUTAK
Putative pyruvate, phosphate dikinase regulatory protein
Cutibacterium
MAESPLEIHVIADSTGETAVRLARAARSQFEGVHWHIVRHPMIGTVPEMVSALEAVSEAHEAGQWVCVVHTLVLPDMRRMVSDACEEMGIRELDLMGPMLEAMEEASGLDADAVPRRPVGVEADYFTRISAMEFAVRNDDGAIPDRLTEADICLVGVSRSGKTPLSIYLGYLGYKTVNVPLVPGIAPPTELAAVDRWRIVGLTIDAQRLLEIRGRRVRGLGGFGNEDGYADLAAIYEELDEVGKIQRRLGCPIIDTTGLALEESATKVIDVVDQRAKTAGTRLRKPAGSYRMRP
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.
Q6A651
A6W1C6
ISPE_MARMS
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Marinomonas
MDYSVNKMQLPSPAKLNLFLHITGRREDGYHELQTLFQFIDLCDTLDFSLTRNNQITISPIIEQLPTEDNLIYKAAKLLTPFKKDSTFGIDIILTKQLPMGGGIGGGSSNAATALLALNVLWGCQLSLEKLAELGVQLGADIPVFVMGFAAFAEGVGEKLQKVELDTPYFLLIKPNCHVSTGQIFTDKYLTRDTPPIRISHALKLGGHNDCLDVVKKHNPEVNEAYLWLKNYGDAKLTGTGACLFLAFDNLRDAERVRSSTPTKWQSWVCRGCNTSPTHAALNQWIEQNRGVPHIKHHLSQSFLG
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
A6W1C6
A3CLL8
TRPD_STRSV
Anthranilate phosphoribosyltransferase
Streptococcus
MKEIIAKLADFKDLSSAEMTDVIERIVTGRVTESQIVAFLLGLKMKGETIEERTALAQVMRGHAKQIPTTIRTAMDNCGTGGDKSFSFNISTTAAFVLAGGGIKMAKHGNRSISSKSGSADVLEALGINLDLDAASLGKVFEQTGIVFLFAKNMHPAMKYIMPARLSLGIPTIMNLTGPLIHPMSLETQLLGTSRPDMLESTAEVLKNMGRKRAVVVSGPDGLDEAGLHGRTQYALLADGQISLHSFLPSDIGMEEISLEVIRGGNAKENAEILLSVLQNQASPYLETTVLNAGLGFYANGKSDSIEEGIALARQVIASG...
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
A3CLL8
P32300
OPRD_MOUSE
MSL-2
Mus
MELVPSARAELQSSPLVNLSDAFPSAFPSAGANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAF...
G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Sig...
P32300
Q0SQB6
DISA_CLOPS
Diadenylate cyclase
Clostridium
MRTVHDDELKKILKIMSPGTSLREGLDNILRAKTGGLIVLGDNEEILDLVDGGFNINSEYSPAYIYELAKMDGALVLTSDRKRILYANAQLMPNQSISTFETGTRHRTAQRVAKQTNKIAIAISQRRNIITVYKGDIKYVLRDSAVILSKANQAIQTLEKYVAVLERVTNNLNILEFQDLATLFDVTTAIQRTEMVMRIVEEIEGYIIELGNEGRLISMQLNELVRSIEQDGVLLIRDYCYDKMEYNDVYKEIQELSAEDLLDLDIIAKELGYVGKSLIDTLVSPRGYRISSKIPRIPSNVIENLVGHFGKLKYILEAGN...
Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal...
Q0SQB6
Q6HLF4
ILVC1_BACHK
Ketol-acid reductoisomerase type I
Bacillus cereus group
MAKVYYEKDVTVNVLKEKKVAIIGYGSQGHAHAQNLRDNGFDVVVGLRKGKSWDKAKEDGFSVYTVAEAAKKADVVMILLPDELQPEVYEAEIAPNLQAGNSLVFAHGFNVHFDQVKPPVNVDVFLVAPKGPGHLVRRTFVEGGAVPALFAVYQDATGVATEKALSYADGIGATRAGVLETTFKEETETDLFGEQAVLCGGVTALVKAGFETLVDAGYQPELAYFECLHELKLIVDLMYEGGLENMRYSVSDTAQWGDFVSGPRVVTEDTKKAMDTVLAEIQDGTFARGWIAEHKAGRPNFHATNEKENEHEIEVVGRKL...
Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobu...
Q6HLF4
P08331
CPDB_ECOLI
2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase
Escherichia
MIKFSATLLATLIAASVNAATVDLRIMETTDLHSNMMDFDYYKDTATEKFGLVRTASLINDARNEVKNSVLVDNGDLIQGSPLADYMSAKGLKAGDIHPVYKALNTLDYTVGTLGNHEFNYGLDYLKNALAGAKFPYVNANVIDARTKQPMFTPYLIKDTEVVDKDGKKQTLKIGYIGVVPPQIMGWDKANLSGKVTVNDITETVRKYVPEMREKGADVVVVLAHSGLSADPYKVMAENSVYYLSEIPGVNAIMFGHAHAVFPGKDFADIEGADIAKGTLNGVPAVMPGMWGDHLGVVDLQLSNDSGKWQVTQAKAEARP...
This bifunctional enzyme catalyzes two consecutive reactions during ribonucleic acid degradation. Converts a 2',3'-cyclic nucleotide to a 3'-nucleotide and then the 3'-nucleotide to the corresponding nucleoside and phosphate.
P08331
P07237
PDIA1_HUMAN
p55
Homo
MLRRALLCLAVAALVRADAPEEEDHVLVLRKSNFAEALAAHKYLLVEFYAPWCGHCKALAPEYAKAAGKLKAEGSEIRLAKVDATEESDLAQQYGVRGYPTIKFFRNGDTASPKEYTAGREADDIVNWLKKRTGPAATTLPDGAAAESLVESSEVAVIGFFKDVESDSAKQFLQAAEAIDDIPFGITSNSDVFSKYQLDKDGVVLFKKFDEGRNNFEGEVTKENLLDFIKHNQLPLVIEFTEQTAPKIFGGEIKTHILLFLPKSVSDYDGKLSNFKTAAESFKGKILFIFIDSDHTDNQRILEFFGLKKEECPAVRLITL...
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrang...
P07237
Q9I3H5
BVMO_PSEAE
Baeyer-Villiger monooxygenase
Pseudomonas
MYTPANNHNRSLAMSTQPTPAAARHCKVAIIGTGFSGLGMAIRLRQEGEDDFLIFEKDAGVGGTWRVNNYPGCACDVQSHVYSFSFEANPEWTRMFARQPEIRAYLEKCWEKYRLQEKTLLNTEIGKLAWDERQSLWHLHDAQGNHYTANAVVSGMGGLSTPAYPRLDGLENFQGKVFHSQQWDHDYDLKGKRVAVIGTGASAIQFVPEIQPLVAALDLYQRTPPWILPKPDRAISETERRRFRRFPLVQKLWRGGLYSLLEGRVLGFTFAPQVMKLVQRLAIRHIHKQIKDPELRRKVTPDYTIGCKRILMSHNYYPAL...
Catalyzes a Baeyer-Villiger oxidation reaction, i.e. the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters or lactones using NADPH and/or NADH as an electron donor. Thus, can convert bicyclo[3.2.0]hept-2-en-6-one into the oxidative lactone products 2-oxabicyc...
Q9I3H5
Q8PPL8
LIPA_XANAC
Sulfur insertion protein LipA
Xanthomonas
MTQPIARSIPLQVVSGDTAAPAPLQTGVKQIGGDKINRSPVQFVDAPVLRKPSWIRVRIPSGNAVQNLKAKLRENRLVTVCEEASCPNIHECFSHGTATFMILGEVCTRRCSFCDVAHGRPKPPDASEPASLAATVADMGLKYVVVTSVDRDDLRDGGAQHFVDCISAIRTSSPNTRIEILTPDFRGKGRMDRALEILALSPPDVFNHNIETVPDLYPNVRPGADYQWSLTLLQRFKAQHPSIATKSGIMLGLGETMEQVQATLRDLRAHDVDMITIGQYLQPTPHHHPVMRYWTPEEYKALEDYGNALGFSHVASGPMV...
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
Q8PPL8
A7Z7A7
HEM1_BACVZ
Glutamyl-tRNA reductase
Bacillus amyloliquefaciens group
MHILVVGVDYKSAPIEIREKISFQPDELAEAMLRLKGEKSVLENIIVSTCNRTEIYAVVDQLHTGRYYIKTFLSEWFSLPKEELSPFLKFYESDAAIEHLFRVACGLDSMVIGETQILGQVRSSFKTAQAEKTIGTIFNELFKQAVTVGKRTHAETDIGANAVSVSYAAVELAKKIFGSLSNKHILILGAGKMGELAAENLHGQGIGKVTVINRTFLKAKALADRFSGEARSLNQLEHALAEADILISSTGASDFVVSKEMMERAGRQRKGRPLFMVDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANLQERRETAEK...
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
A7Z7A7
C3K3K0
YQGF_PSEFS
Putative pre-16S rRNA nuclease
Pseudomonas
MALRLILGFDYGTKQIGVAVGQVITGQARELCTLKAQNGIPDWNQVEALIKEWKPDAVVVGLPLNMDGTPSDMCLRAEKFARRLNGRYNIPFYTHDERLTTFEAKGERRDRGGQKGSYRDNPVDAIAAALLLQGWLDENTALFES
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
C3K3K0
Q7TQP3
GP119_MOUSE
G-protein coupled receptor 119
Mus
MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISGLVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGLVAGACIAGLWLVSYLIGFLPLGVSIFQQTTYHGPCSFFAVFHPRFVLTLSCAGFFPAVLLFVFFYCDMLKIASVHSQQIRKMEHAGAMAGAYRPPRSVNDFKAVRTIAVLIGSFTLSWSPFLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLYHMALGVKKFFTSILLLLPARNRGPERTRE...
Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.
Q7TQP3
P80458
MDH_RHOPA
Malate dehydrogenase
Rhodopseudomonas
MARDKIALIGSGQIGGTLAHLVGLKELGDVVLFDIAEGVPQGKALDIAESSPVDGFDSKLTGANSYEAIEGARVVIVTAGVPRKPGMSRDDLLSINLKVMEQVGAGIKKYAPDAFVICITNPLDAMVWALQKASGLPAKKVVGMAGVLDSARFRYFLADEFNVSVEDVTAFVLGGHGDTMVPLVKYSTVAGIPLPDLVKMGWTSQARLDEIVDRTRNGGAEIVNLLKTGSAFYAPASSAIAMAESYLKDKKRVVPVAAHLNGEYGVKDMYVGVPVVIGDKGVERIVEIELAGKDKEAFDRSVAAVQGLVEACKKIAPDLL...
Catalyzes the reversible oxidation of malate to oxaloacetate.
P80458
A4WVK5
RL2_CERS5
50S ribosomal protein L2
Cereibacter
MALKSYKPTTPGQRGLVLIDRSELWKGRPVKTLVEGLIKTGGRNNTGRVTMWHKGGGAKRLYRIVDFKRRKFDVPAVVERIEYDPNRTAFIALVRYEDGELAYILAPQRLAVGDSVIAGAKTDVKPGNAMPFSGMPIGTIVHNVELKPGKGGQLARAAGTYAQFVGRDGGYAQIRLSSGELRMVRQECMATVGAVSNPDNSNQNFGKAGRMRHKGVRPTVRGVAMNPIDHPHGGGEGRTSGGRHPVTPWGKGTKGNRTRKSKASDKLIVRSRHAKKKGR
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
A4WVK5
P57603
RPE_BUCAI
Ribulose-phosphate 3-epimerase
Buchnera
MNKFFLAPSILSADFARLGEDIKKVIDAGSDLIHFDVMDNHYVPNLSMGPMILESLRNYNITAPIDVHLMVKPVDNLIPQFAKAGATFITFHPEATLHIERTLNLIKENGCKAGLAFNPATPLNFLDYILEKLDLILLMSVNPGFGNQSFLPSTFNKLREVRKIIDANFSDILLEVDGGVKLDNIADIACAGANVFVMGSGLFKYSNYKLVIEKIRKKLEYAHSRSIH
Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.
P57603
Q0HQB2
KATG1_SHESR
Peroxidase/catalase 1
Shewanella
MDKTQSSQGKCPVMHGANSAVASNNMDWWPKALNLDILHQHDKKTDPMDPKFNYREAFNSLDLAAVKRDLNALMTDSQDWWPADWGHYGGLMIRMAWHSAGTYRVADGRGGAGTGNQRFAPLNSWPDNANLDKARRLLWPIKKKYGNKLSWADLMILAGNVAYESMGLKTYGFAGGREDIWHPEKDIYWGSEKQWLAPTENPNSRYSGERDLENPLAAVMMGLIYVNPEGVDGKPDPLRTAQDVRVTFARMAMNDEETVALTAGGHTVGKCHGNGKAQDLGPEPEGEELEAQGLGWLNKKGPGTGANAVTSGLEGAWTTH...
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
Q0HQB2
A3Q537
NUON_MYCSJ
NDH-1 subunit N
unclassified Mycobacterium
MNPEEAMRPLLMASEMMMFGAGLVALIAGSFLRRQRQWWVGVMAAAAQVGVIGVAVVQMVGPDQMAFEGAFSVDTATGVARIACAAGLLLIWAVAGAEMRASPREAETYALLMFSATGVLVLAGAEDLLLLVAGYFLASIPLYGLVGLARSAAAAEAAMKAYLMGALFGILLMLGVTILYGLTGATRYPQLAMTLSGAPAVAVAAGVVGVLAGLMFEAGGVPAHFWVPDAAQGANATAATFLTTVPKIGALVALYRLTTVLPDTLAWPVLIAVFAVISMTLGNLAAYWQQDPRRLLGWSTVSQVGYLLVPITVAGASELA...
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions ar...
A3Q537
Q57L24
NADK_SALCH
ATP-dependent NAD kinase
Salmonella
MNNHFKCIGIVGHPRHPTALTTHEMLYRWLCDQGYEVIVEQQIAHELQLKNVPTGTLAKIGQQADLAVVVGGDGNMLGAARTLARYDINVIGINRGNLGFLTDLDPDNALQQLSDVLEGRYISEKRFLLEAQVCQQERQKRISTAINEVVLHPGKVAHMIEFEVYIDETFAFSQRSDGLIISTPTGSTAYSLSAGGPILTPSLDAITLVPMFPHTLSARPLVINSSSTIRLRFSHRRSDLEISCDSQIALPIQEGEDVLIRRCDYHLNLIHPKDYSYFNTLSTKLGWSKKLF
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Q57L24
P0C1W9
CA4A_CONPR
Alpha-conotoxin PeIVA
Embrikena
CCGVPNAACHPCVCTGKC
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin has higher affinity for the fetal (alpha-1/beta-1/gamma/delta subunits) subtype (IC(50)=<5 nM) of the receptor than for the adult (alpha-1/beta-1/epsilon/delta) subtype (IC(50)=40...
P0C1W9
Q9T9X3
NU6M_PONPY
NADH dehydrogenase subunit 6
Pongo
MTYALFLLSVILVMGFVGFSSKPSPIYGGLVLIISGAVGCAVILNCGGGYMGLVVFLVYLGGMMVVFGYTTAMAIEEYPEAWGSGAEVLVSVLVGLVMEVGLVLWVKECDGVVVAVNFNSVGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTLFVGVYVVIEIARGN
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Q9T9X3
Q0K967
HFQ_CUPNH
RNA-binding protein Hfq
Cupriavidus
MSNKGQLLQGPFLNALRKEHVPVSIYLVNGIKLQGNIESFDQYVVLLRNTVTQMVYKHAISTVVPARAVNFRVDDAAEA
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.
Q0K967
P0DA88
EFTS_STRP3
Elongation factor Ts
Streptococcus
MAEITAKLVKELREKSGAGVMDAKKALVETDGDMDKAVELLREKGMAKAAKKADRVAAEGLTGVYVHGNVAAVVEVNAETDFVAKNAQFVELVNATAKVIAEGKPANNDEALALVMPSGETLAEAYVNATATIGEKISFRRFALIEKTDEQHFGAYQHNGGRIGVISVVEGGDDALAKQVSMHIAAMKPTVLSYTELDAQFIKDELAQLNHAIELDNESRAMVDKPALPFLKYGSKAQLSDDVITAAEADIKAELAAEGKPEKIWDKIIPGKMDRFMLDNTKVDQAYTLLAQVYIMDDSKTVEAYLDSVNAKAIAFARFE...
Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.
P0DA88
Q0VNK6
PYRC_ALCBS
Dihydroorotase
Alcanivorax
MTDSLTIARPDDWHLHFRDGDLLAETVPATANVFGRAIVMPNLTPPVNTVAEAAEYRERILAQVPAGVNFEPLMVLYLTDSTPVQEVERAANSDFVHALKLYPAGATTNSDSGVTDPGKITHLYEAMEKHDVPLLVHGEVTDAEVDIFDRERVFIDRYLADIRDQFPALRIVFEHVTTAEGVNFVREANALTAATVTPQHLLMNRNDLLVGGVRPHNYCLPILKRRQHQEAIQKAVIEGNSRFFLGTDSAPHARTKKEAACGCAGCYSARAALPLYATFLEQHNALDKLEGFASHFGADFYRLPRHTDTVTLVRKPWAVP...
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Q0VNK6
P40884
IMA5_YEAST
Isomaltase 5
Saccharomyces
MTIIHNPKWWKEATVYQIYPASFKDSNNDGWGDLAGITSKLDYVKELGVDAIWVCPFYDSPQEDMGYDIANYEKVWPRYGTNEDCFQMIEEAHKRGIKVIVDLVINHCSEEHEWFKESRSSKANPKRDWFFWRPPKGYDEKGNPIPPNNWRSFFGGSAWRYDEKTGEFFLHVFALGQPDFNWENEECRKAIYDSSVGYWLRHNVDGFRIDVGSMYSKVEGLPDAPITDPTVPYQKGTEFFINGPRIHEYHKEMHNYMLSQVPEGKEIMTVGEVGIGNEDDFRVYTSAKEGELNMMFNFKHTSVGENPKCKYELIPFTLKD...
Alpha-glucosidase with specificity for isomaltose, maltose, and palatinose.
P40884
P46024
BAMA1_HAEIF
Protective surface antigen D15
Haemophilus
MKKLLIASLLFGTTTTVFAAPFVAKDIRVDGVQGDLEQQIRASLPVRAGQRVTDNDVANIVRSLFVSGRFDDVKAHQEGDVLVVSVVAKSIISDVKIKGNSVIPTEALKQNLDANGFKVGDVLIREKLNEFAKSVKEHYASVGRYNATVEPIVNTLPNNRAEILIQINEDDKAKLASLTFKGNESVSSSTLQEQMELQPDSWWKLWGNKFEGAQFEKDLQSIRDYYLNNGYAKAQITKTDVQLNDEKTKVNVTIDVNEGLQYDLRSARIIGNLGGMSAELEPLLSALHLNDTFRRSDIADVENAIKAKLGERGYGSATVN...
Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
P46024
Q3II81
RS18_PSET1
30S ribosomal protein S18
Pseudoalteromonas
MARYFRRRKFCRFKAEGVQQIDYKDLATLRNYVTESGKIVPSRITGTSAKYQRQLATAIKRARYLALLPYTDLHK
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Q3II81
Q8NMU4
LARC_CORGL
Nickel-pincer cofactor biosynthesis protein LarC
Corynebacterium
MGLWIDATAGVAGDMLLGALIDAGAELEKIQQVVEAVIPGDVLLRTEEVVRQGQRGIKLHVDAQHEHHHHRHLSTIKELLVNADIPEQTKQDALGVFELIAIAEGKVHGIEPEKIHFHEVGAWDSIADIVGVCEAIRQLNPGLIAASPIALGFGRIKAAHGDIPVPVPAVAELVKGWPTQTGALMESTEPVGELATPTGVALIRHFATQDGPFPGGIINEVGIGAGTKDTEGRPNIVRAILFNTSRSNPDTRTLVQLEANVDDQDPRLWPGVIEILFAAGAVDAWLTPILMKKGRPAHRVSALVDSSEVEAVKTALFAAT...
Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes.
Q8NMU4
A8AX28
TRUB_STRGC
tRNA-uridine isomerase
Streptococcus
MNGIINLKKEAGMTSHDAVFKLRKILGTKKIGHGGTLDPDVVGVLPIAVGKATRMVEFMQDEGKVYEGEITLGYSTTTEDASGEVVAETPVLSPLDEKLVDEAIASLTGPITQIPPMYSAVKVNGRKLYEYARAGQEVKRPERQVTIYQFERTSPISYEGQLARFTFRVKCSKGTYIRTLSVDLGEKLGYAAHMSHLTRTSAAGMRLGDALTLEQIAERVAEEDYSFLQPLELGIGDLLKVELSDEQVEDVRNGRFISLVSDEAELAGFYGEKLVTILEKRKDQFKPRKVFL
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
A8AX28
Q1GU76
ATPF_SPHAL
F-type ATPase subunit b
Sphingopyxis
MADFTLILAEGVVEPTAFGLDATVWVSIAMLVFLGILVWKGVPGAIAAMLDKRIAEISKQLGEAEQLRLDAESLKAEYEAKLADAAKEADEMRARADAEAQALVAKAKADATALIARRKQMAEDRIAAAEANALAEVRAAAVKAATEAAAKLIADRHDVAADKALVDQAIASIAKG
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
Q1GU76
B5E853
NUSB_CITBB
Antitermination factor NusB
Citrifermentans
MTTRREGRELALQALYSKDLVLQDANTTLKRITESFSEGEEPTLSVNSKAYAFASELVNGVVSNLQAIDSRIAEKSKHWSMARMARVDLNILRLAVFELLYRPDIPKNVTMNEAIEVAKKFGADDSASFVNGILDEIASTVTDKE
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
B5E853
A8MGE4
HEM3_ALKOO
Pre-uroporphyrinogen synthase
Alkaliphilus
MKIRVGSRESKLAVKQSEIVIEAIRKYDPNIEIELVTMKTTGDIKLDQTLDKIGGKGLFIKELDQALYDDRVDITVHSFKDMPMAIDEYLPIVAVSKREDPRDVLVLPKTVKEPDFSKPIGCSSFRRKIQLQEIYPHCSVEPIRGNVLTRLEKLDRGEFSAITLALAGLKRLGLEERISRIFEVTEILPAACQGVIVVQARKGFDVSFLSDFHDKEAWDISMAERSFVRTLNGGCSSPVAAYGEIKDNYLTLTGLYVDSSNSVHKKTITGARKQGEEMGFNLALQMKGEDEVHGKD
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
A8MGE4
A7HBM2
RS19_ANADF
30S ribosomal protein S19
unclassified Anaeromyxobacter
MARSIKKGPFADKHLTKKVEDANKGNKKSVIKTWSRRSTILPDFVGHTFAVHNGRKFVPVFVTENMVGHKLGEFAPTRTFHGHSAEKKAAAAPARK
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
A7HBM2
B6YQF1
FMT_AZOPC
Methionyl-tRNA formyltransferase
Candidatus Azobacteroides
MTASKARIVFMGTPDFAVASLDALIGEGYNVVGVVTIPDKSIGKHQSIPQFSPIKQYALSHEIPLLQPKKLKDPDFLKSLKAWNTDLQVVVSFRLLPEVVWNMPSLGTFNLHASLLPQYRGAAPINWAIINGEKETGVTTFFLDYEIDTGKIIAQECIPIKETDNAGTIHDELMYLGAKLVVKTTNDILSGTVKLISQDETNLGKQKLKIAPKIFREVCKIDWNKTTREIHNFIRGLSPYPGAWTELTCVKGMTFPFKIFETEKADCHDYSLPVGTIVSDKKVYIDVRTKDGFIRLRNVQLAGKKRMPVTDFLKGNAYLL...
Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.
B6YQF1
G5EGB2
LIN29_CAEEL
abnormal cell lineage 29
Caenorhabditis
MDQTVLDSAFNSPVDSGIAGTTTGSGSTTHFGVGTNFKVSVRSSSRSTDGTDSTDGANSDNVTGSTGSTPAHHSITNLNMALSQHSIDSATAASSTNPFPHFNQADLLNFHQNSLLPHHMFSQFGRYPQFEQKPDVGVLQQQMQMREAKPYKCTQCVKAFANSSYLSQHMRIHLGIKPFGPCNYCGKKFTQLSHLQQHIRTHTGEKPYKCKFTGCDKAFSQLSNLQSHSRCHQTDKPFKCNSCYKCFTDEQSLLDHIPKHKESKHLKIHICPFCGKSYTQQTYLQKHMTKHADRSKASNFGNDVVPADPFDPSLLSWNPM...
Required for seam cell fusion.
G5EGB2
Q9PL68
MAP1_CHLMU
Peptidase M
Chlamydia
MKRNDPCWCGSQKKWKHCHYPTKPERPSDNLRQLYASRYDIIIKTPDQIEKIRKACQVTARILDALCKAAKEGVTTNELDQLSCNLHKQYNAIPAPLNYGQPPFPKTICTSLNEVICHGIPNDTPLQNGDIMNIDVSCIVDGFYGDCSRMVMIGEVPEIKKKVCEASLEALNAAIAILEPNLPLYEIGEVIENCAARYGFSVVDQFVGHGVGVRFHENPYVAHHRNSCKIPLAPGMTFTIEPMINVGKKEGFIDPTNHWEARTCDHQPSAQWEHTVLITDSGYEILTLLDN
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.
Q9PL68
Q7W668
TSAD_BORPA
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Bordetella
MIILGFESSCDETGVAAVCTERGLLAHALHTQIAMHQEYGGVVPELASRDHIRRVVPLTRQVLAEAGLTLADVGAVAYTAGPGLAGALLVGASVAQALAWSRALPAIGIHHLEGHLLSPLLAEPRPEFPFVALLVSGGHTQLMRVDGVGRYELLGETLDDAAGEAFDKSAKLMGLGYPGGSALARLAEQGDASRYDLPRPMLHSGDLDFSFSGLKTAVLTRVKAATRDGGELGEQDRADLAAATQAAIVEVLAAKAIRALKQTGLRRLVVAGGVGANALLRAHLARALKPLRAEAYFPPLSLCTDNGAMIAFAAAERVKA...
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct ca...
Q7W668
Q493F6
FETP_BLOPB
Probable Fe(2+)-trafficking protein
Candidatus Blochmannia
MSKIIYCVFLKKYAEGLDAPCYPGALGKYIYEHISNIAWMQWQDKQTILINENKLNMMNIADRTILEKEMKIFLFGKNFSIKNN
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
Q493F6
Q7VM84
FDHE_HAEDU
Protein FdhE homolog
Haemophilus
MSIRILPENEIKPSASAFEIPPLLFANPKNLYTRRAKRLRELAKNNPLRDYLEFAAHLVDIQLTLLETAPIGNYAEKLTAYLTENQGQKPLNKQQFARDEKWLELLLALIKQCKPYATGAILTTLEFLEKASYAELNNLADHLLNERYEQVSPDQSVFIWLALSLYWTQLAQQLPRHTQAEIGERHTCPVCGSAPITSVIHLDKTQGLRYLHCALCESEWNMTRAQCSNCDESGDLNYWSFDTVEAPIKAESCGDCHSYLKVLYQEKDPYVEPLADDLASLMLDIEMEQKGFVRSGLNPFLFSIE
Necessary for formate dehydrogenase activity.
Q7VM84
Q8ECL5
SSTT_SHEON
Na(+)/serine-threonine symporter
Shewanella
MKQESSFLAKLANGSLVLQILVGIIAGVALASFSHEWAKQVAFLGSLFVGALKAIAPILVFILVASSIANQKKNTQTNMRPIVVLYLLGTFAAALTAVILSMMFPTTLVLAAGVEGTSPPQGISEVISTLLFKLVDNPVNALMTGNYIGILAWGVGLGLALHHSSDSTKQVFADVSHGISQMVHFIIRLAPIGIFGLVAATFAETGFAAIAGYAQLLAVLLGAMAFIALIINPLIVYVKIKRNPYPLVIRCLRESGMTAFFTRSSAANIPVNMALCEKLKLHEDTYAVSIPLGATINMGGAAITITVLTLAAAHTLGIQV...
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
Q8ECL5
Q12WM8
HEM3_METBU
Pre-uroporphyrinogen synthase
Methanococcoides
MILGTRGSALAIAQADLVTKMLEEKGHELTRNVIKTSGDVFTDRPLHEVAGVGVFVRELDDRMIEGEVDIAVHSMKDLPTVRPPELAIAAVLKRDSPYDVLLTADGSTLDELPDGAIIGTTSMRRRAQLLRYRPDLNVEDLRGNINTRIQKLKAGQYDGILLAEAGLQRMGWDMDVQRLPAEAFCPSANQGTIVVVTRADDEAERACSVLNHERSRMETEVERLLITDVEGGCIVPIGSFAQMNEDGDEIHVLVEVLAVDGTREIRIEDDIPVKNYREHALSIGRMLVEMGGKELVQEAVCEMSGCDDE
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Q12WM8
Q2NQX9
ZAPB_SODGM
Cell division protein ZapB
Sodalis
MAFEVFEKLEAKVQQAIDTITLLQMEIEELKEKNNSLSQEVQQAQNNRESLVNENEQLRQEQNVWQERLRGLLSKMDEV
Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA.
Q2NQX9
Q8FMF8
IPYR_COREF
Pyrophosphate phospho-hydrolase
Corynebacterium
MSVEVTVEIPKGSRNKYEIDHETGKVYLDRYLFTPMAYPLDYGFIDHTLGEDGDPMDALVILPESVFPNVIVKSRVIGVFKMTDEAGGDDKLLAVLDDPRYDHIQDISDVSDFLKDEIEHFFVHYKDLEKGKHVDGSGWGDKAEAEQILADSIERYKA
Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
Q8FMF8
P53914
NAT10_YEAST
Ribosomal RNA cytidine acetyltransferase 1
Saccharomyces
MAKKAIDSRIPSLIRNGVQTKQRSIFVIVGDRARNQLPNLHYLMMSADLKMNKSVLWAYKKKLLGFTSHRKKRENKIKKEIKRGTREVNEMDPFESFISNQNIRYVYYKESEKILGNTYGMCILQDFEALTPNLLARTIETVEGGGIVVILLKSMSSLKQLYTMTMDVHARYRTEAHGDVVARFNERFILSLGSNPNCLVVDDELNVLPLSGAKNVKPLPPKEDDELPPKQLELQELKESLEDVQPAGSLVSLSKTVNQAHAILSFIDAISEKTLNFTVALTAGRGRGKSAALGISIAAAVSHGYSNIFVTSPSPENLKT...
RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) at positions 1280 and 1773 in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis . Catalyzes the formation of ac4C at pos...
P53914
S0DQN6
FSR3_GIBF5
Fusarubin biosynthesis cluster protein 3
Fusarium fujikuroi species complex
MKNTQTNGTHPIIDKKPNGTLNGDHQEYPTFSQEKLDDSIKRGIDLQVFRYPSTGINVLIAGAGLGGITCALECWRKGHNVRIIDRSPSPVWTGDNVQIQPSAILLLRHWPDMGYEIEENQYDVDMSYYRQTGERIWGPAPPMFNDPEHLPGRRGFPSVNAHSRIKLYRAFLKQAERVGIYVEWGCKVVEYWEDVEGHAGGVVLENGEKRTADIVVAADGLRTKSMTIVPGMPDQLTTSGKAIYRAGYPVEHALKDPTVREMWNFKPEDKPIWQFWLGNGSHNMMCLTHDLAFWSFIHSHAESASESWIPDIDPAEVITE...
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of fusarubins, highly pigmented naphthoquinones responsible for the coloration of the fruiting bodies . The non-reducing polyketide synthase FSR1 is responsible for the condensation of seven acetyl-CoA units to yield a haptaketide . Af...
S0DQN6
Q1C0X4
DSBD_YERPA
Protein-disulfide reductase
Yersinia
MAQRFITLILLLCSVLLAPHSAQSSLFGENASFGTKNSQSRFIPVDQAFAFDFHQQGDQLNLSWQIHPGYYLYRQQIKIVPQQAALGAFTLPEGITHHDEFYGEVEIFKQQLTLKIPITQAAEQASVSVTYQGCAEAGFCYPPETRVIPLDVVVAASTASGTAAVNSSATVNPPATTQPEGDATPVPSTLPFSPLWALLIGIGIAFTPCVLPMYPLISAVILGREKPHSQRRILILAVVYVQGMALTYTLLGLVVAAAGLQFQAALQHPYVLIGLSVLFVLLALSMFGLYSLQLPSSLQTRLTQWSNSQRGGSLAGVFAM...
Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps.
Q1C0X4
Q4L7J1
PTPA_STAHJ
Phosphotyrosine phosphatase A
Staphylococcus
MVDVAFVCLGNICRSPMAEAIMRQRLIDRNISGVNVYSKGTGKWNLGEPPHEGTQDILNRHNIPFDGMISELFESSDDFDYIIAMDQSNVDNIQNINPNIKGKLFKLLEFSNMEESDVPDPYYTNNFEGVYEMVQSSCDNLIDFIVKDANLKEG
Dephosphorylates the phosphotyrosine-containing proteins.
Q4L7J1
Q399J3
AZOR2_BURL3
FMN-dependent NADH-azoreductase 2
Burkholderia cepacia complex
MRLLNIVSSPRGARSASIAVARAFVDAYRQTGATIDVDTLNVWEEDLPDFDSGAIGAKYKGVANAPMDEAEQSIWRRIQSLVKRFQDADRIVVGVPMWNFGYPYKLKQLIDLVSQRNMLFTFDGNAYAPLLEIPRALVIHVRGQSREPGAGADNPGFRHQADYIEFWLRFIGVSEVRSLTVEHTWGARASDSIERAQARAVEMAAEF
Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
Q399J3
O07631
BIPA_BACSU
GTP-binding protein BipA
Bacillus
MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERAMDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVDAYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQLEFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYNDYVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLVAVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPF...
A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal prote...
O07631
P48858
RT12_CHOCR
Ribosomal protein S12, mitochondrial
Chondrus
MPTFKQLLKKPRKIVLTKSKSIALIQCPQKKGICMKVYTTSPKKPNSAERKVAKVNLTNGKSIIGYISGEGHTLQEHSLVLVRGGRVKDLPGVQYHFVRGVYDLHAVGTRKKSRSKYGKKLFKAPIV
Protein S12 is involved in the translation initiation step.
P48858
B8HMF0
TRMD_CYAP4
tRNA [GM37] methyltransferase
unclassified Cyanothece
MRFDVVTLFPDFFTSPLASGLLGKALAKQIAEVYLLNPRDFTTDKHHRVDDESYGGGVGMVLKPEPIFAAVESLPVLPRREVILMSPQGERLDQALLQSLADNFDQLVVICGHYEGVDERVVDHLVTREISLGDFVLTCGEIPALTLLNGVIRLLPGTVGKAESLQNESFIDGLLDFPHYTRPADFRGWPVPQVLRSGHHAEVDRWRRTQQIQRTRDRRPDLYQRWLNSLPPDSLQDFTV
Specifically methylates guanosine-37 in various tRNAs.
B8HMF0
O43189
PHF1_HUMAN
Polycomb-like protein 1
Homo
MAQPPRLSRSGASSLWDPASPAPTSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAREVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVPRAPAPGEGEGTSWVCRQCVFAIATKRGGALKKGPYARAMLGMKLSLPYGLKGLDWDAGHLSNRQQSYCYCGGPGEWNLKMLQCRSCLQWFHEACTQCLSKPLLYGDRFYEFECCVCRGGPEKVRRLQLRWVDVAHLVLYHLSVCCKKKYFDFDREILPFTSENWDSLLLGELSDTPKGERSSRLLSALNSHKDRFISGR...
Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however ...
O43189