accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q49X44
RRF_STAS1
Ribosome-releasing factor
Staphylococcus
MSDIINETKSKMQKSIDNLSRELANISAGRANSNLLNGVNVDYYGAPTPVQQLASISVPEARLLVISPYDKSSVGNIEKAINAANLGVNPSSDGEVIRISVPALTEERRKELVKDVKKIGEDAKVAVRNVRRDSNDELKKQQKNSDITEDDLRTQTDDVQKLTDDSIKEVEKLLEEKEQDIMSV
Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.
Q49X44
Q4ZNQ4
RLME_PSEU2
rRNA (uridine-2'-O-)-methyltransferase
Pseudomonas syringae
MARSKTSHNWLKEHFDDKYVKMAQKDGYRSRASYKLLEIQEKDKLIRPGMTVIDLGAAPGGWSQVTSRLIGGQGRLIASDILEMDSIPDVTFIQGDFTEDAILEQILEAVGNTQVDLVISDMAPNMSGLSAVDMPRAMFLCELALDLAGRVLRPGGDFLIKVFQGEGFDVYHKDIRKLFDKVQMRKPSSSRDRSREQYLLARGFRGIDGAASIERF
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Q4ZNQ4
P59807
CABC1_PROVU
Endochondroitinase ABC
Proteus
MPIFRFTALAMTLGLLSAPYNAMAATSNPAFDPKNLMQSEIYHFAQNNPLADFSSDKNSILTLSDKRSIMGNQSLLWKWKGGSSFTLHKKLIVPTDKEASKAWGRSSTPVFSFWLYNEKPIDGYLTIDFGEKLISTSEAQAGFKVKLDFTGWRAVGVSLNNDLENREMTLNATNTSSDGTQDSIGRSLGAKVDSIRFKAPSNVSQGEIYIDRIMFSVDDARYQWSDYQVKTRLSEPEIQFHNVKPQLPVTPENLAAIDLIRQRLINEFVGGEKETNLALEENISKLKSDFDALNIHTLANGGTQGRHLITDKQIIIYQPE...
Endolytic, broad-specificity glycosaminoglycan lyase, which degrades the polysaccharides chondroitin, chondroitin-4-sulfate, chondroitin-6-sulfate, dermatan sulfate and to a lesser extent hyaluronan, by beta-elimination of 1,4-hexosaminidic bond to unsaturated tetrasaccharides and disaccharides. Is not active against k...
P59807
P48697
RBL_CUCPE
Ribulose bisphosphate carboxylase large chain
Cucurbita
SVGFKAGVKDYKLTYYTPEYETKDTDILAAFRVTPQPGVPPEEAGAAVAAESSTGTWTTVWTDGLTSLDRYKGRCYGIEPVPGEENQYIAYVAYPLDLFEEGSVTNMFTSIVGNVFGFKALRALRLEDLRIPTAYIKTFQGPPHGIQVERDKLNKYGRPLLGCTIKPKLGLSAKNYGRAVYECLRGGLDFTKDDENVNSQPFMRWRDRFLFCAEAIYKSQAETGEIKGHYLNATAGTCEEMMKRAIFARELGAPIVMHDYLTGGFTANTSLAHYCRDNGLLLHIHRAMHAVIDRQKNHGMHFRVLAKALRLSGGDHIHAG...
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate in the photorespiration process. Both reactions occur simultaneously and in competition at the same active site.
P48697
Q5R5Z0
MOB3A_PONAB
Mps one binder kinase activator-like 2A
Pongo
MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKKAQASLNAGLDLRLAVQLPPGEDLNDWVTVHVVDFFNRVNLIYGTISDGCTEQSCPVMSGGPKYEYRWQDEHKFRKPTALSAPRYMDLLMDWIEAQINNEDLFPTNVGTPFPKNFLQAVRKILSRLFRVFVHVYIHHFDRIAQMGSEAHVNTCYKHFYYFVKEFGLIDTKELEPLKEMTARMCH
May regulate the activity of kinases.
Q5R5Z0
P17844
DDX5_HUMAN
RNA helicase p68
Homo
MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQEHPDLARRTAQEVETYRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGDGPICLVLAPTRELAQQVQQVAAEYCRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLECGKTNLRRTTYLVLDEADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYIHINIGALELSANHNILQIVDVC...
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA....
P17844
Q3IYN1
SECA_CERS4
Protein translocase subunit SecA
Cereibacter
MLGLGTLARKIFGTPNDRKVKSVRSLVARINDLEPEFQALSDEGIKQKTAEFQRRVQEGGESLDDLLPEAFANCREGARRALGLRAFDVQLMGGIFLHQGNIAEMKTGEGKTLVATFPAYLNALAGKGVHVVTVNDYLAKRDAEWMGKVYAQLGLATGVVYPFQSDEEKKAAYAADITYATNNELGFDYLRDNMKASKEEMRQRGHFFAIVDEVDSILIDEARTPLIISGPSQDRSDLYTKVDKLIPELLEEHYKLDEKTRNVTFTEEGNEFLEKRLLETGLLPEGQSLYDPESTTIVHHVNQGLRAHKLFNRDQQYIVR...
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor drivin...
Q3IYN1
Q5X0T2
LPXB2_LEGPA
Lipid-A-disaccharide synthase 2
Legionella
MIKEKRLRIAMVAGELSGDLLGAGVIRELKQHLTNVEFMGVGGPQMLKEGFHSLIDISELSVMGISDVLRRYPQLYLIRERLLREWTINPPDVFIGIDYPDFNLSVEARLKKQHIKTIHLVSPKVWAWRQKRVHLIKKAVDLVLTLFPFEEAFYLQHGVSAQFIGHPLADLIEINPSCSALRKKYNYHSDDTILAVLPGSRVGEIKYMGPLFLEVMQRIAMERPHVHFIVPIACQDLYPVFFKQLHAEYDYLKIQVIQGNAREAMAISDVVLTKSGTATLEAMLLKRPMVVAFKWGILTHAIIAPQVKVPYIALPNLLAG...
Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
Q5X0T2
Q9UUF0
PEX10_SCHPO
Peroxisome assembly protein 10
Schizosaccharomyces
MHLSAHIDPLQIILCTEIDEACIQFIKSQIEGIARACGPRMQANFEGVLIPYVDVLGKFLYRACCLRYATMGEEAARIVLAKQDRSKGLVLATTGERMTSLIFSLVIDLVGVHVNKLLKQASYSSSFKLPFGLRNLLPEAVISKEKHLVYILNSFKPILLKLVSIIRFLCLTMKGHCATVSQLLLGLKYISLDEINPEEKKKVLTLLLLLGSRLIASILQHSNSYFDQHTISSITDERDLEDKNKLPFIPEGNRKCSLCMEFIHCPAATECGHIFCWSCINGWTSKKSECPLCRAFSSPSKIILLR
Somewhat implicated in the biogenesis of peroxisomes.
Q9UUF0
C0QQ02
KATG_PERMH
Peroxidase/catalase
Persephonella
MDKKECGFSIDDFLYAVEGGNTISKWWPHRLNLKILQQNNPDLVPFDKNFNYREEFSKLDYFELKEDIRRIMRESQEWWPADYGHYGPLFIRMAWHSAGTYRIIDGKGGANGGNQRFAPVNSWPDNVNLDRARRLLWPVKKKYGNKISWADLMILAGNVALEDMGFKTIGFGGGREDIWEPEIDTYWGPETEWLADMRHSEEGKIKGPLAAVQMGLIYVNPEGPNGEPDVLGAAKDIKESFGKMGMSIEETVALIAGGHTFGKCHGAADPSKYLGPEPEAAPIEQQGLGWKNSYGTGKGKDTITSGLEGAWTPTPIKWDN...
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
C0QQ02
Q9XFI1
TRL12_ARATH
Lilium-type thioredoxin 1-2
Arabidopsis
MDAISSLGTNCVLSGVSPFSQENQSKSKLSPFMSLDLKEHPMASADFTNQTLTAFSSSSASPFQAKTSSIGMSRGMRWWEKSTNHNMLEIQSANHLVDSLLNAGDRLVVLDFYSPGCGGCKSLHPKICQLAETNPNVMFLKVNQEELRTMCHGLNVHVLPFFKFYRGAEGKVCSFSCTIATINKFKKALDKHGSERCSLGDAKGLDEKELAALASVGELKMNSLTMHQASNIGYKTEEQYQTMVL
Probable thiol-disulfide oxidoreductase that may participate in various redox reactions.
Q9XFI1
A9WH61
RS7_CHLAA
30S ribosomal protein S7
Chloroflexus
MPRRGNIERRPIPPDARYNSVLVQKFINKVMERGKKSLAERIVYQALDLAAERLKKPQMEIFEQALRNASPSIEVRPKRVGGATYQVPVEVKSDRRYSLAMRWLLMSARARTGKPMVERLAAELIDAYNNTGTTIKRKEDVHRMAEANRAFAHYGRL
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
A9WH61
A7NIA2
RSMH_ROSCS
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Roseiflexus
MLSSRFLVLGAQFSVLSALDYHHTPVLLTETLAGLQPHPGGWYIDGTVGGGGHAAAILEATAPDGRLLGIDCDPAALAAAAARLAPYGERVTLVRGSFREIGRLAHKAGFVQVQGVLLDLGVSSYQLDTPERGFSFQASAPLDMRLDPDAPMTAANLVNDLPERDLADLIFRYSEERGSRRIARAIVEARQRRPITTTDELAEIVSRALGGRRGRIHPATRTFQALRIAVNDELTSLDAALPQIVELLVVGGRMAIITFHSLEDRIVKQFMRAEAQAGHLRLITRKPVEASSEEQRINPRSRSAKLRVAERA
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
A7NIA2
B4EES6
RUVA_BURCJ
Holliday junction ATP-dependent DNA helicase RuvA
Burkholderia cepacia complex
MIGRIAGILLEKNPPHLLVDCNGVGYEIDVPMSTFYNLPQTGERVVLLTQQIVREDAHLLYGFLTQQERTTFRELLKITGIGARMALAVLSGMSVQELAQAVTMQDAARLTRLPGIGKKTAERLLLELKGKLGADLGALAGAASPSDHATDILNALLALGYSEKEGLAAIKNVPAGTGVSEGIKLALKALSKA
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA...
B4EES6
Q9Y6G5
COMDA_HUMAN
COMM domain-containing protein 10
Homo
MAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKSLEKVLVEFSHKELFDFYNKLETIQAQLDSLT
May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes . May down-regulate activation of NF-kappa-B .
Q9Y6G5
B0K9X7
ACP_THEP3
Acyl carrier protein
Thermoanaerobacter
MIFEKVRDIIAEQLGIDPEEITMESSFIDDLGADSLDIVELIMALEEEFDIEIPDEDAEKIKTVGDVVEYLSNLE
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
B0K9X7
Q0IH72
EXOG_XENLA
Endonuclease G-like 1
Xenopus
MVASFSWRLLSPRFLGGFVLGAAASSASCVAALQLYDKREPELAPVAPEEKDPLEEYGFPLTGTEARQYINHALAYDPAKRTPKWVIEHLSRTKTVGSADRKHCKFKPDPNIPKMFSATNEDYLGSGWTRGHMAPAGDNKFSTEAMAETFYLSNIVPQNYENNAGFWNRMEMYCRDLTKRFEDVWVVSGPLELPTSHEDGKKRVTYEVIGADEVAVPSHLYKVILVREKGSEQPLAIGAFVVPNSPIGFDHQLPEYKVQLEDLEKMSGLLFFPQLDRDKGLKPLCDVDSCRLIQLHEFKLYIAARRVGGARNLQKLERIL...
Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single-stranded DNA and 5'-3' exonuclease activity.
Q0IH72
A5VLK3
RL23_LIMRD
50S ribosomal protein L23
Limosilactobacillus
MEARDIILRPVVTEASMAGMDNKRYTFDVDLRATKTQVKNAVEEIFGVKVVKVNIMNVKGKLKRQGRYEGYTKRRRKAIVTLSADSNEIKLFNDNNEN
One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.
A5VLK3
A2C585
MIAA_PROM1
Isopentenyl-diphosphate:tRNA isopentenyltransferase
Prochlorococcus
MQPNKPLVIALMGPTASGKTELAIDIAKKINSNIHNIDSRQIYIDMDIGTAKPTAVQQSQVNHFLIDVCLPSKPINLHDFQSIAQTSIERDLEKKGLTLLVGGSGLYLQALIGGLNPPAVPPQKFLRDQLKKIDKTELHKLLKLCDPFSAQRIHPEDSIRIIRALEVFYATGKMFSKEKNMTPIPWRVLELGVNPENLISRIQRRTEEMYKKGLIEETEDLINKYGKNLQLLKTIGYGEARSMINGKINYEEALEITIKRTCQLAKRQKTWFRNKHHSKWLNNENALPEALTSIYEFLG
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
A2C585
A4J9S0
MNMG_DESRM
Glucose-inhibited division protein A
Desulforamulus
MRYHAGDYDVIIVGAGHAGCEAGLAAARMGCKTLVLTLNLDNIALMPCNPAVGGPAKSHLVKEIDALGGQMGLTTDLAAIQMRMLNTGKGPAVYALRAQADKVKYQQLMKKNLETQENLDVKQLLVEEILVKNGRVTGVATQIGAEFSARAVVVTTGTYLKGRIIIGNVHFPGGPNSQFPSVNLSENLRSLGLELGRFKTGTPARVDRRTIDFTKMTIQPGDEEVHNFSYISPVTQREQVPCWLTYTTEKTHEIIRENLHRSPLYSGIIEGVGPRYCPSIEDKIVRFADKPQHQIFVEPEGLHTYEMYVQGMSTSLPPDV...
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
A4J9S0
D3ZJ96
UBP28_RAT
Ubiquitin-specific-processing protease 28
Rattus
MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEALKASNGDITQAVSLLTDQRVKEPSHDTAATEPSEVEESATSKDLLAKVIDLTHDNKDDLQAAIALSLLESPNIQTDSRDLNRIHEANSAETKRSKRKRCEVWGENHNPNNWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNILENCRSHTEKRNIMFMQELQYLFALLLGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVNVNSNPRTKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQ...
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by ...
D3ZJ96
E7F5F0
AKL2A_DANRE
Augmentor alpha-1
Danio
MRALRAPVLVMGLVLLICTAAQSDASANKVEKTLRRIMEIMRQVENSADDESAQKTESAPEPKDTHHLKTASGETILEIFPRDLSRKEKFITILTGRRLSNPLRHQSCVFETSDLVVFHPSGPLYFGPKCKKDVYRLYHNTRDCTIPAHYKRCARLLTRLAGTRKCQEG
Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK . Required for neural crest cell differentiation and iridophore development during embryonic iridophore development and adult stripe development by acting as a receptor for LTK .
E7F5F0
P39714
BDH1_YEAST
(R,R)-butanediol dehydrogenase
Saccharomyces
MRALAYFKKGDIHFTNDIPRPEIQTDDEVIIDVSWCGICGSDLHEYLDGPIFMPKDGECHKLSNAALPLAMGHEMSGIVSKVGPKVTKVKVGDHVVVDAASSCADLHCWPHSKFYNSKPCDACQRGSENLCTHAGFVGLGVISGGFAEQVVVSQHHIIPVPKEIPLDVAALVEPLSVTWHAVKISGFKKGSSALVLGAGPIGLCTILVLKGMGASKIVVSEIAERRIEMAKKLGVEVFNPSKHGHKSIEILRGLTKSHDGFDYSYDCSGIQVTFETSLKALTFKGTATNIAVWGPKPVPFQPMDVTLQEKVMTGSIGYVV...
NAD-dependent (R,R)-butanediol dehydrogenase which catalyzes oxidation of (R,R)-butane-2,3-diol to (3R)-acetoin, of meso-butanediol to (3S)-acetoin, and reduction of acetoin. Allows the use of 2,3-butanediol as an aerobic carbon source.
P39714
Q8GXV5
UGHY_ARATH
(S)-ureidoglycine aminohydrolase
Arabidopsis
MRSLYLIVFIVISLVKASKSDDGFCSAPSIVESDEKTNPIYWKATNPTLSPSHLQDLPGFTRSVYKRDHALITPESHVYSPLPDWTNTLGAYLITPATGSHFVMYLAKMKEMSSSGLPPQDIERLIFVVEGAVTLTNTSSSSKKLTVDSYAYLPPNFHHSLDCVESATLVVFERRYEYLGSHTTELIVGSTDKQPLLETPGEVFELRKLLPMSVAYDFNIHTMDFQPGEFLNVKEVHYNQHGLLLLEGQGIYRLGDNWYPVQAGDVIWMAPFVPQWYAALGKTRSRYLLYKDVNRNPL
Involved in the catabolism of purine nucleotides. Can use (S)-2-ureidoglycine as substrate, but not allantoate. The sequential activity of AAH, UGLYAH and UAH allows a complete purine breakdown without the intermediate generation of urea.
Q8GXV5
Q2HNT2
TSH1A_XENLA
Teashirt 1A
Xenopus
MPRRKQQAPRRSAAYVPEEELKAADIEEDNLEDDGLSLDVQDSEYLYNDEHEIKETPSYQNSPISSATNQDAGYGSPFSETSDHLADFKSTSSKEGQDKEDGQNTENVSYPTDSLAQIKAVYTNLLSECCWSNLALDLKKSNENSSPTTNTNKSSMSEATGSTSDPDTPTTIPSSSCTNTSTSISVTTSNSTNSNSASGYDWHQAALAKTLQQTSYGLLPEPSLFSTVQLYRQSNKIYGSVFTGASRFKCKDCSAAYDTLVELTVHMNETGHYRDDNKDRDAERTKRWSKPRKRSLMEMEGKEDAQKVLKCMYCGHSFES...
Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Involved in two major neuronal regionalization processes: primary anteroposterior (AP) axis patterning of the CNS and segmentation of the cranial neuronal crest (CNS) development.
Q2HNT2
A0NXQ9
T3HPD_ROSAI
Trans-L-3-hydroxyproline dehydratase
Roseibium
MRSTKTIHVISCHAEGEVGDVIVGGVAPPPGETLWEQRSFIARDQTLRNFVLNEPRGGVFRHVNLLVPPRHPEADAAFIIMEPEDTPPMSGSNSICVSTVLLDGGIVPMIEPITEMVLEAPGGLVRVKAECRNGKAERIFVQNVTSFADKLSVPLDVEGIGTLTVDTAYGGDSFVVVDAEALGFAIVEDEAKDIARLGVRITNAANEQLGFSHPENPDWNHISFCAFCGPLSQTPTGLTGRSAVAIQPGKVDRSPTGTAVSARMALMAARGQMTIGDTFEAVSIIGSSFTGRIVSQQMAGDRPGIVPEISGRGWITGIHQ...
Catalyzes the dehydration of trans-3-hydroxy-L-proline (t3LHyp) to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be involved in a degradation pathway of t3LHyp, which would allow L.aggregata to grow on t3LHyp as a sole carbon source. Displays neither proline racemase activity nor 4-hydroxyproline 2-epimerase activity.
A0NXQ9
Q3JZ09
DTD_STRA1
Gly-tRNA(Ala) deacylase
Streptococcus
MKIIIQRVNQASVSIEDDVVGSIEKGLVLLVGIAPEDTTEDIAYAVRKITSMRIFSDDEGRMNLSIQDIKGSVLSISQFTLFADTKKGNRPAFTGAADPVKANQFYDIFNQELANHVSVETGQFGADMQVSLINDGPVTIVLDTKNK
An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By rec...
Q3JZ09
L8BU87
CA1A_CONLI
Alpha-conotoxin LvIA
Lividoconus
FRGRDAAAKASGLVGLTDRRGCCSHPACNVDHPEICG
Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks alpha-3-beta-2/CHRNA3-CHRNB2 nAChR with high selectivity (IC(50)=8.67 nM (on rat) and 17.5 (on human)) . Has also weaker activity on alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/C...
L8BU87
Q6G2E2
METN_BARHE
Methionine import ATP-binding protein MetN
Bartonella
MENPSLISLKKISRCFNTTTDICALDNLSLNIHAGEILGIIGRSGAGKSTLIRCLNGLERIDAGSIFFEGVNVSNLSETEWAPYRQRIGMIFQHFNLLSSQNILNNIALPLKLTGINKKQRHKRALELIELVGLCGKEYCYPAELSGGQKQRVGIARSLAANPKILLSDEATSALDPETTQSILELLADINKRLNLTIVLITHEMEVVRAIAHRVVVLNQGRIVEEGRVKDIFTSPQDDTTIAMLKLVTPQLPEKFAKNLKPRGQEAIIEINIAGEITQQPFLNLLEDEIGLRARILHGGIDTVQGETIGRLFLGLPAQN...
Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
Q6G2E2
P0CD48
NU2C1_SOLTU
NADH-plastoquinone oxidoreductase subunit 2 A
Solanum
MIWHVQNENFILDSTRIFMKAFHLLLFDGSLIFPECILIFGLILLLMIDSTSDQKDIPWLYFISSTSLVLSITALLFRWREEPMISFSGNFQTNNFNEIFQFLILLCSTLCIPLSVEYIECTEMAITEFLLFVLTATLGGMFLCGANDLITIFVAPECFSLCSYLLSGYTKKDVRSNEATMKYLLMGGASSSILVHGFSWLYGSSGGEIELQEIVNGLINTQMYNSPGISIALIFITVGIGFKLSPAPSHQWTPDVYEGSPTPVVAFLSVTSKVAASASATRIFDIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSM...
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translo...
P0CD48
B2FUP5
CCA_STRMK
Phosphatase
Stenotrophomonas maltophilia group
MKIYLVGGAVRDRLLQRPAGDHDWVVVGATPAQMEAQGYTAVGRDFPVFLHPKTGEEYALARTERKSGRGYRGFVVDADPGVTLEEDLQRRDFTINAIACDEETGTLVDPYGGVRDIEQRVLRHVGPAFVEDPLRVLRAARFMARFAPLGFTVAEETMALMREIAASGELDALVPERVWQELRKALVSERPSAFLRTLHDAHALGPILPELEALYGVPQRAEFHPEVDTGIHQEMVSDMAAKLAPGDDLVGFAALTHDLGKGLTPPEEWPRHIMHEQRGIKPLKALCARLKIPAEHQQLAEAVCREHLNVHRIDELRDAT...
Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase a...
B2FUP5
O22683
CYNS_ARATH
Cyanate lyase
Arabidopsis
MEAAKKQSVTNQLLAVKSASGKTFSQLAAETGLTNVYVAQLLRRQAQLKPDTVPKLKEALPALTDELIGDMMSPPWRSYDPNLIQEPTIYRLNEAVMHFGESIKEIINEDFGDGIMSAIDFYCSVDKIKGVDGNNRVVVTLDGKYLSHSEQRTENMVSRLNLKGGTSE
Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.
O22683
B1VFK0
RL25_CORU7
General stress protein CTC
Corynebacterium
MAELTRIEGVLRTEFGKGASRRLRRDGRIPLVVYGNELDPVHVHVDTLDLHALVRNEGVNAVFELNIDGEDNLVMVKAIDQNVLTLDIDHADLLNVKRGERVEVEVPVIHEGLPAPGAMVVQDVDVLLLEVDVLDIPEEIVLDINGLEIGEQILAKDVKMPSNAVLVSDAEELVINIVEPEEEELPEDDEAAAEGEDAAAGEEAEAPAESED
This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.
B1VFK0
Q1IFV0
RL18_PSEE4
50S ribosomal protein L18
Pseudomonas
MTDKKVTRLRRARKARLKMHELEAVRLCVFRSSQHIYAQVISADGSKVLASASTLDKELRDGATGNIDAATKVGKLVAERAKAAGVSQVAFDRSGFKYHGRVKALADAAREGGLEF
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Q1IFV0
Q9K3L9
RLMG_STRCO
rRNA (guanine-N(2)-)-methyltransferase RlmG
Streptomyces albidoflavus group
MTTPWGERVLSRFPEDPRDRLRAWDASDEYLLGHLAEREVPLSGTVVVVGDRWGALVTALAPHRPVQITDSHLAREATRVNLERSGVEPGSVRLLTTQDPPPDRVDVLLVRVPKSLALLEDQLLRLAPALHEGTVVVGTGMVKEIHTSTLRLFERIVGPTRTSLAVKKARLIFAEPDPALKRPANPWPLGYRLPDDVGRLSGRPVVNHAGVFCADRLDIGTRFFLRHLPAPGRFRRVVDLGCGNGVVGTAVSLADPDAELLFTDESFQAVASARATYRANEVAGQAEFRVGDGLAGVPDGSVDLVLNNPPFHSHQATTGA...
Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA.
Q9K3L9
Q9TSN6
LALBA_BUBBU
Lactose synthase B protein
Bubalus
MMSFVSLLLVGILFHATQAEQLTKCEVFRELKDLKDYGGVSLPEWVCTAFHTSGYDTQAIVQNNDSTEYGLFQINNKIWCKDDQNPHSSNICNISCDKFLDDDLTDDIMCVKKILDKVGINYWLAHKALCSEKLDQWLCEKL
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose o...
Q9TSN6
Q9HRC7
TFE_HALSA
Transcription initiation factor TFIIE
Halobacterium
MAFEDLLDDPVVQKYLHELVGPKGMPVAAAPPDGEVTDEELAERLGLELNDVRRALFILYENDLATYRRVRDEDSGWLTYLWTFQYENVPGNLREEMDRLLEALVDRREYELENEFYLCEVCSIRFEFGEAMDLGFECPECGSAVEAMENTDLVDAMDDRIERLRSELAVEA
Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription i...
Q9HRC7
Q9HUA6
OPGH_PSEAE
Glucans biosynthesis glucosyltransferase H
Pseudomonas
MNNPSTTKAPLADYLAHLPLAEEERERLGESASFSELHARLAGAEGAAADAGGDPALASVRARLQLGTPELDDAEMFGVDAQGRTFLKISPPIRRTKVIPEPWRTNILVRGWRRLTGRSNPPKPKRALPRARWQRVGSLRRFILLLLMLAQTSVATYYMKGILPYQGWAFVDLEELAQQSLLDTVQQVLPYVIQFGILALFAILFCWVSAGFWTALMGFWELLTGRDRYRISGSSAGSEPIAADARTAIVMPICNEDVPRVFAGLRATVESMAATGEMERFDFFVLSDTNDPDIAVAEQQAWLELCRETKGFGKIFYRRR...
Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs).
Q9HUA6
A2C7N3
PURA_PROM3
IMP--aspartate ligase
Prochlorococcus
MSLANVVVIGAQWGDEGKGKITDLLSRSADVVVRYQGGVNAGHTIVVDDKVLKLHLIPSGILYPETICLIGSGTVIDPKVMLKELDMLLENSIDISGLQLASTAHVTMPYHRLLDEAMEQQRGDQRIGTTGRGIGPTYADKSQRNGIRVLDLLDSQRLRERLRGPLQEKNRLLEQIYGVAPLDSEQVIEEYLGYGQRLAPHVVDCIQTIHQAARSRKNILFEGAQGTLLDLDHGTYPYVTSSNPISGGACIGAGVGPTLIDRVIGVAKAYTTRVGEGPFPTELEGSINEQLCDRGGEFGTTTGRRRRCGWFDGVIGRYAV...
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
A2C7N3
O58655
IF2A_PYRHO
eIF-2-alpha
Pyrococcus
MPRKAREYPEEGEFVVATVKRIHNYGAFLELDEYPGKEAFMHISEVASTWVRNIRDYLKEGQKVVAKVIRVDPRKGHIDLSLRRVTQQQRKAKLQEFKRAQKAENLLRLAAEKLGKDFEAAWREVWVPLEEEWGEVYAAFEDAAKDGIEVLKGHVPDEWLPVLKEIVENYVEVPTVTIDAEFEITVPKPNGVEIIKEALIRARDRANKEKDIEVKFTYQGAPRYRIDITAPDYYKAEEVLEDIAEEILRVIKQAGGEATLLRKEKRIRKVKKRKK
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
O58655
Q5A8N2
CARP4_CANAL
Secreted aspartic protease 4
Candida
MFLQNILSVLAFALLIDAAPVKRSTGFVTLDFNVKRSLVDPKDPTVEVKRSPLFLDIEPTEIPVDDTGRNDVGKRGPVAVKLDNEIITYSADITIGSNNQKLSVIVDTGSSDLWVPDSNAVCIPKWPGDRGDFCKNNGSYSPAASSTSKNLNTPFEIKYADGSVAQGNLYQDTVGIGGVSVRDQLFANVRSTSAHKGILGIGFQSNEATRTPYDNLPITLKKQGIISKNAYSLFLNSPEASSGQIIFGGIDKAKYSGSLVDLPITSDRTLSVGLRSVNVMGQNVNVNAGVLLDSGTTISYFTPNIARSIIYALGGQVHYD...
Secreted aspartic peptidases (SAPs) are a group of ten acidic hydrolases considered as key virulence factors. These enzymes supply the fungus with nutrient amino acids as well as are able to degrade the selected host's proteins involved in the immune defense. Activates host systemic immunity. During infection, plays an...
Q5A8N2
Q1RGV0
AAPAT_RICBR
Transaminase A
belli group
MSIISTQLNAIKPSPTLAVVRKTLELKRAGIDIIALGAGEPDFDTPDNIKEAAIKAIKDGFTKYTNVEGIPALKEAIQAKFKRENNIDYDLEEIIVSTGGKQVIYNLFMASLNKGDEVIIPAPYWVSYPDMVLLAEGTPVFANCGIESNFKLSGEALEQLITPKTKWLIINSPSNPTGASYSHSELKNIAEVLRKHPYVNVMSDDIYEHITFDGFKFYTLAEIAPDLKDRIFTVNGVSKAYSMTGWRIGYGAGSKALIKAMTIIQSQSTSNPCSISQVAAVEALNGVQGYIAQNALNFEKKRDLALSILQRVKYFECYKP...
Catalyzes the reversible conversion of aspartate and 2-oxoglutarate to glutamate and oxaloacetate. Can also transaminate prephenate in the presence of glutamate.
Q1RGV0
Q57IC9
GPMI_SALCH
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Salmonella
MSVSKKPMVLVILDGYGYREEQQDNAILNAKTPVMDALWAKRPHTLIDASGLEVGLPDRQMGNSEVGHVNLGAGRIVYQDLTRLDVEIKERTFFANPVLTNAVDQAKNAGKAVHIMGLLSAGGVHSHEDHIMAMVELAAERGAEKIYLHAFLDGRDTPPRSAEASLKKFEDKFAAQGKGRVASIVGRYYAMDRDNRWDRVEKAYDLMTLAQGEFQADTAVAGLQAAYARDENDEFVKATVIRAEGQADAAMEDGDTLIFMNFRADRAREITRAFVNADFDGFARKKVVNLNFVMLTEYAADIKTTVAYPPASLANTFGEW...
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
Q57IC9
Q5SPD7
P5CR3_DANRE
Pyrroline-5-carboxylate reductase-like protein
Danio
MSLSGASDKTSDSPDVFQIKIGFIGAGNMAFGVAQGIIASGKVPPSNIIISAPSMNNLPRFKEKGVSVTHSNHEVVGGSRLIFLAVKPHIIPQVLKEISQEVTKEHIIVSMAAGITIATLEELLPAGTHVIRIMPNLPCMLLEGALLLSCGSHAGEQEETLLKTLLGPCGLVEFGPESWIDAHVGLSGSGVAFVYVFAEALADGAVKMGMPSTLARRIAAQTILGAGVLLRDSGKLPAELKAEVCTPGGTTIHGIHALEKGGFRAAAIGAVEAASERARELGNKQKKN
Enzyme that catalyzes the last step in proline biosynthesis. Proline is synthesized from either glutamate or ornithine; both are converted to pyrroline-5-carboxylate (P5C), and then to proline via pyrroline-5-carboxylate reductases (PYCRs). PYCRL is exclusively linked to the conversion of ornithine to proline.
Q5SPD7
A6VKT7
GLPB_ACTSZ
Anaerobic glycerol-3-phosphate dehydrogenase subunit B
Actinobacillus
MNFDVVIIGGGLAGLTCGIALQEQGKRCAIVNNGQAAMDFSTGSIDLLGRLPNGENVQKVDRALAGLSEQLPAHPYAKLGAERVLAKAKQFEGMAAKLNLGLAGSVEQNHARVTPLGGLRRTWLSPDSVPTVRPNEAFPYNNIVILGIEGYHDFQPQLLADNLKLQPQFAHCEIKPGFLTIPELDFLRRQSREFRSVHIAQTLEQKVNPASLINEIRQAASGADVVFLPACFGQNSQAFFNELQAATDFMLFELPTLPPSLLGGRQHNILRQYFERLGGVMMNGDRALRAEFEGNRVVKLFTRIHEDEPLAADNYVLASG...
Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor.
A6VKT7
Q6GMG6
S5A3B_DANRE
Riboflavin transporter 2-B
Danio
MSLFTHVLACLFGIGSWVAINGMWVELPLIVTAIPEGWLLPSYLTIIIQMANIGPLFITLMHRFRPGVLDERPVIYTIVAVGVVATFLLAFLWKHTLTFGDGEHSAALLSLSFLLSVVDCTSSVTFLPFMMRLQPQYLTTYFIGEGLSGLVPALVALVQGVGVVHCKNASANANFSLGNISQSLLETHYQPANFSTQGFFLFLSAMMMVCLGAFLLLNLHPAVAREHKSMKGYIDDSRRVEKIDLSQSPNDETPEQRPMLDFPEGSAIKQRSSFGKGTYSRTELVFIFVVLAWVNALTNAVLPSVQSYSCLPYGNQAYHL...
Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism.
Q6GMG6
Q886Z3
RLMN_PSESM
tRNA m2A37 methyltransferase
Pseudomonas
MIASTGKTNLLGLTQQEMEKFFDSIGEKRFRAGQVMKWIHHFGVDDFDAMTNVSKALREKLKACAEVRGPEVVSEDISSDGTRKWVVRVESGSCVETVYIPQGKRGTLCVSSQAGCALDCSFCSTGKQGFNSNLTAAEVIGQVWIANKSFGSVPATVDRAITNVVMMGMGEPLLNFDNVIAAMHLMMDDLGYGISKRRVTLSTSGVVPMIDELSKHIDVSLALSLHAPNDALRNQLVPLNKKYPLKVLLESCRRYMSSLGEKRVLTIEYTMLKDINDKVEHAVEMIELLKDTPCKINLIPFNPFPHSGYERPSNNAIRRF...
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
Q886Z3
Q1QYS2
PXPA_CHRSD
5-oxoprolinase (ATP-hydrolyzing) subunit A
Chromohalobacter
MPLPLLNCDMGESFGNWKMGLDDEVMPYVDCANIACGFHASDPGIMRRTVALAVQHGVRVGAHPAYPDLQGFGRRSLACSPREVEDMMLYQIGALEGMCRAEGTRVAYVKPHGALYNDMARDPELLRGAMRAVLAYDPELPLLAMATADPAPMRALAEEMGVTLWFETFADRAYDPQGRLVSRREPGAVHHDREAIVAQAVTLARGEPLTANDGSLLHLPADTLCVHGDNAESVAAVRAIRDAFDGLARE
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
Q1QYS2
Q54WD6
TRM5_DICDI
tRNA methyltransferase 5 homolog
Dictyostelium
MNVLNKEVFNQTKKVLGLIVSNKLVNGFSKQFKSYMFQSPKFKPIVSTDNDDKKMIYLCDTLKKETDIPDQLKTFIKENDIKVIEKDISLNYNNFSYEQVLKTLLPKDVGIPFSFERIGHIIHVNLKDEQLPFKYIIGQAILDKNIQVKTVLNKVGEIDTVFRTFKIEILAGEPDLVAEIKENECIFRFNFEEVYWNSRLQYEHMELVNTFKKEDIICDMFAGVGPFALPAAKIKKCKVYANDLNPSSVKYMKENAKTNRLESKVEISNLDARDFVKSLVEKSIPFTHVVMNLPSTSIEFLDVFRDIFLNSTIPPPIPPP...
Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required...
Q54WD6
B2JKH4
BIOB_PARP8
Biotin synthase
Paraburkholderia
MSQIQTAPLPVMPSQAAAAADAAASRWKVADVAALYELPFNDLLFRAQQVHREHFDANTVQLSTLLSIKTGGCEEDCAYCPQSVHHETGLKAEKLMEVEEVLAAARVAKENGATRFCMGAAWRNPKDRHLEPIKDMIRGVKSMGLETCVTLGMLEAHQAQALREAGLDYYNHNLDTSPEFYGQIISTRTYQDRLDTLEHVRDAGINVCCGGIVGLGESRRERAGLIAQLANMEPYPESVPINNLVQVEGTPLTGTEALDPFEFVRTIAVARITMPRAMVRLSAGREQMDEALQAMCFLAGANSIFYGDQLLTTSNPQAEA...
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
B2JKH4
Q8U1Z9
KHSE_PYRFU
Homoserine kinase
Pyrococcus
MKVYAPATIANFGPGFDVFGLAIETPRDTVIAKESDDFRIEVEGYKVPENDENVALVAAKALFKLVGEEGGIYLKLKKGIRPKSGLGSSGASSIAGAVAAARILGVEDDEIIIRAALEGERKASGSPHGDNVVPSYYGNFTIVESLNPLRVHNIEVDFKVVVILPSVEVPTSEARKVLPKKVPLKDAVKNIALASSLVLALKEGNLEEVGRLLEDHLALPYRLSLVPWFPKVKEAAKEAGAYGVMISGSGPAVFALGENLKEIGKAMKEAFESFGIEAEYWVTKVGRGAKWC
Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.
Q8U1Z9
B2FHI7
SYE_STRMK
Glutamyl-tRNA synthetase
Stenotrophomonas maltophilia group
MTCRTRFAPSPTGYLHIGGARTALYCWLEARHRGGEFVLRIEDTDRERSTQGAIDAILEAMEWLGLDYDEGPIYQTDRVARYLEVAEQLVADGKAYYAYETREELDAMREAAMARQEKPRYNGAARDLGLPRRDDPNRVIRFKNPLEGTVVFDDLIKGRIEIANSELDDMVIFRPDGYPTYNFAVVVDDWDMGITEVIRGDDHINNTPRQINLYEGIGAPVPKFGHMPMILDEQGAKLSKRTGAADVMQYKDAGYLPDALLSYLARLGWSHGDQELFSRQELIELFDVKDCNSKASRLDMAKLGWVNQHFLKTEDVAAIV...
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
B2FHI7
O08776
NDUF3_RAT
Nuclear protein E3-3
Rattus
MATALGFRCLYRTRPATLGRYVDRLWRSPSRGHRLSPADDELYQRTRISLLQNEFPQAVYIDSYNSRGFTINGNRVFGPCALLPQTVVQWNVGSHQDITEESFSIFWMLEPRIEIVVVGTGNKTERLHSQVLQAMRQRGIAVEIQDTPNACATFNFLCHEGRVTGAALIPPPGETALASSGQTTE
Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).
O08776
O43980
M1PAS_EIMTE
Mannitol-1-phosphatase
Eimeria
MAETEWTPEALSGRYEEIKSCIPQQLEAYARFLREAAPEDLRRWQQIAQDLKLELNLENGRIKYKKEFKPLELPVDICYIRHGKTQGNTEPRVFQGQVDYANNQLTQQGQQQAAAAATKLEAMAAAKEFIPDLLLSSPLLRAVHTAQPFVDANPKPLFRVLPELAEMAFGEWDNRKVAELEKDDPAHLFYLQQNAVIKAKGPHRICCQLWQSPEWLEGKKELPAENFLECLDRQRKALIKVGEIAKELCGPSCGERKPRVAVYGHSMAGAAVSVLLGFGKEDQLGFLGFDGNYIMPNATPTILIPNAKP
Key enzyme for mannitol biosynthesis.
O43980
A5FS85
ISPG_DEHMB
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Dehalococcoides
MITRRQSTEIRLGNLTIGGSAPISVQSMTKTDTRNIPATIAQIKELEECGCEIIRLAIPDMEAASALKSIRPKVKIPIVADIHFDYRLALASLSAGVDGLRLNPGNIGDPERVKAVVKSAKEREIPIRIGVNAGSLPKDLPPELTIAQKMVKAAMGHIKILEGLDFGLIKVSLKAFDVPTTIEAYTQIASLIPYPLHVGITETGTPKTGLVRSAVGIGNLLYMGIGDTIRVSLTAPPHEEVFAAYEILKSLNLRQRGPILVSCPTCSRTEVDIVGIASQVQEALNKIDKPIRVAVMGCAVNGPGEAKEADLGIACGKGQG...
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
A5FS85
B2UZI5
RF1_CLOBA
Peptide chain release factor 1
Clostridium
MLLDKLAFIENKYDELSVKISDPSIMQNQNEWRKLCKEQADLEIIVNAYKEYKQVIEDLQVNKEMLSDESDREMKEMLNEEISSLAEREIELEKEIQILLLPKDPNDDKNVFVEIRGGAGGDEAALFAYNLFRMYTRYAERQRWSTEIMSLNETDIGGFKEVVFMIKGNGAYSKLKYESGVHRVQRVPDTESSGRIHTSTVTVAVLPEVDDVEIEIADKDVRIDVFRASGHGGQCVNTTDSAVRITHLPSGLVVSCQDEKSQLKNKEKAMKVLRSRLFEKAEQERADGIAADRKSQVGTGDRSERIRTYNYPQGRITDHR...
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
B2UZI5
P23551
XYNA_BUTFI
1,4-beta-D-xylan xylanohydrolase A
Butyrivibrio
MKKFKIRKLMARVLALALVFSTFFMVSKVDANAASYNLMETYGAKYGYSGNCVHTHMLRDSRIVNAIKKDSNIVTLGNEMKPDYLLGSRQATLISVDEAKRLGYYIPSNYKERYVPKIDFRTVDEAVKICYENGLKMRGHTLVWHSQTPTWLFRENYSGNGRFVNTATMDARLEFYVKSVMGHFYSGKYGSTLVYWDVCNETLHAQNSGWEAVYGSNKTNAVYVKKAFNYAYQVLEQYKLTNSVKLFYNDYNTYMEVNDVIKLVNYINQGKKVCAGVGMQSHLGTGFPSVDYYTNALNSFLRAGFEVQITELDITNKGDY...
B.fibrisolvens is located in the rumen of ruminant animals, where it contributes to the animal's digestion of plant material by hydrolyzing hemicellulose with its xylanases.
P23551
A4JF27
MSCL_BURVG
Large-conductance mechanosensitive channel
Burkholderia cepacia complex
MSIIKEFKEFAVKGNVMDLAVGVIIGGAFSKIVDSVVKDLIMPVIGVLTGGLDFSNKFILLGTIPPSFKGNPDSFKDLQAAGVAAFGYGSFITVAINFVILAFIIFLMVKFINKLRKPAEAAPAATPEDVLLLREIRDSLKQR
Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
A4JF27
Q66FR8
FADB_YERPS
3-hydroxyacyl-CoA dehydrogenase
Yersinia
MLYQSETLQLHWLENGIAELVFDAPGSVNKLDTKTVANLGEALNVLEKQSELKGLLLRSAKTALIVGADITEFLSLFNAPPEKLHQWLVFANTIFNRLEDLPVPTISAINGYALGGGCECILATDFRIASPEARIGLPETKLGIMPGFGGSVRLPRLLGADSALEIIATGKDVTANDALKIGLVDAVVDPEKLVGSALTMLKQAIDGKLDWQAARRPKLEPLKLNPTEAAMCFTIAKGRVMQVAGKHYPAPLTAVKTIEAAAKFGRTEALNLETNSFVPLAGSNEARALVGIFLNDQYVKAQAKKLSKGVAAPKLAAVLG...
Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.
Q66FR8
A4IMC5
PYRH_GEOTN
Uridine monophosphate kinase
Geobacillus
MEQPKYKRVVLKLSGEALAGKQGFGIQPAVIQSIAKQVKEVAELDVEIAIVVGGGNIWRGKTGSEMGMDRATADYMGMLATVMNALALQDSLEQLGVETRVQTSIEMRQVAEPYIRRRAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILMAKNNVDGVYSADPNIDASAVKYDELSYLDVIQQGLGVMDSTASSLCMDNNIPLIVFSITEEGNIKRAVLGENIGTIVRGK
Catalyzes the reversible phosphorylation of UMP to UDP.
A4IMC5
B4ETC6
PLSX_PROMH
Phosphate-acyl-ACP acyltransferase
Proteus
MTNLTIALDAMGGDFGPRITVPACLRALASNPHLKILLVGQPDSISPLLANQNAELISRLHVIPAEHIVANDAKPSHAIRASKGTSMRVALDLVKTGEAQACVSAGNTGVLMGLAKLRLKAIDGIERPALVSVLPNQKKSKTVVLDLGANVNCDSQMLVQFAVMGAVMAEEIAGIHSPKVALLNIGEEESKGLDNIREAATVLKATPNINYIGYVEGNELLTGKTDVLVCDGFAGNVSLKTMEGVIRVFLSLIKSSTGDNKKTSWWMKLLKKWLQKRLNKRFGHMNPDQYNGASLLGLRGIVIKSHGGANENAFTAAIEQ...
Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.
B4ETC6
A0A0B5A8Q2
INS1B_CONGE
Con-Ins G1b A chain
Gastridium
MTTSFYFLLMALGLLLYVCQSSFGNQHTRTFDTPKHRCGSEITNSYMDLCYRKRNDAGEKRGRASPLWQRRGFLSKLKARAKRNGAFHLPRDGRGVVEHCCHRPCSNAEFRKYCG
This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock. It is one of the smallest known insulin found in nature and lacks the C-terminal segment of the B chain that, in human insulin, mediates engagement of the insulin receptor and assembly of the hormone's h...
A0A0B5A8Q2
B1XSP4
RPOC_POLNS
Transcriptase subunit beta'
Polynucleobacter
MKALLDLFKQTQGDEQFDVIKIGLASPEKIRSWSFGEVRKPEAINYRTFKPERDGLFCAKIFGPTKDYECLCGKYKRLKFRGIICEKCGVEVTLAKVRRERMGHIELAAPVAHIWFLKSLPSRLGMVLDMTLRDIERVLYFEAYVVVDPGMTPEGAMKRGQIMSEDEYIAKTEEYGDGVFTAIMGAEGIRDLLRSIDIDREVETIRADLKATGSDAKIKKYAKRLKVLEAFQTSGIKPDWMIMEVLPVLPPELRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLELRAPEIIVRNEKRMLQEAVDSLLDNGRRGKAM...
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
B1XSP4
C4LY96
PECK1_ENTHI
PEP carboxyphosphotransferase 1
Entamoeba
MFNQEKGTDYPILNIQELEALADLKLSAMGKEYPKHDKSDAIDVVAPLVDIIAEGDQESTAPIDARLQTFLNSYFAECGEEVPKIPDNTFILDREGLGRVLSFPPHKQEFFCETMKSYKIKQGVLHNPAKDKRTTVGVFHICQSDVPVPADKIECPKIAFLRMLKAAFYGAPDDHLIIPYTAECKEPTRSWVSLYMRPVVVPGVKGVKGFEHEKATEMHFFVPGNMVSCLDFVESVFGNAGNPRLSKNDAALDPLGWTGHSGMAILAPHLTRMTKKECGLPHISQATERQKRERMCWEKEDELYNDGKTFKMYCRDASGV...
Inorganic pyrophosphate (PPi)-dependent phosphoenolpyruvate carboxykinase, which regulates the carbon flow of the central metabolism by fixing CO(2) to phosphoenolpyruvate to produce oxaloacetate. Can also produce pyruvate and diphosphate from phosphoenolpyruvate and phosphate.
C4LY96
Q9CWS4
INT11_MOUSE
Cleavage and polyadenylation-specific factor 3-like protein
Mus
MPEIRVTPLGAGQDVGRSCILVSISGKNVMLDCGMHMGYNDDRRFPDFSYITQSGRLTDFLDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANFFTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYNMTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVFALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFITWTNQKIRKTFVQRNMFEFKHIKAFDRTFADNPGPMV...
Catalytic component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRN...
Q9CWS4
Q1RHH0
DNAK_RICBR
Heat shock protein 70
belli group
MGKVIGIDLGTTNSCVAVMEGKEPKVIENSEGERTTPSIIAFANGEKLVGQSAKRQAVTNPRNTVYAVKRLIGRNFTDPMVKKDQEIVPYNIVKADNGDAWVEVEGKKHSPSQISAFILQKMKETAENYLGEKVTQAVITVPAYFNDAQRQATKDAGKIAGLEVLRIINEPTAAALAYGFDKSASKTIAVYDLGGGTFDVSILEIGDGVFEVKSTNGDTFLGGEDFDTRILEHLINTFKKESGIDLRNDPLALQRLKEAAEKAKKELSSALTTDINLPYITADNSGPKHLNIKFTRAELEKLVDDLIEKTIEPCRKALKD...
Acts as a chaperone.
Q1RHH0
Q1CRL4
MIAA_HELPH
Isopentenyl-diphosphate:tRNA isopentenyltransferase
Helicobacter
MDAEIFSLDSLSIYKDINIASAKPSLKERKNIKHYALDHLNIDEKNNAQLFKTLLEDAMRVSSKEILLIVGGSSFYLKSILEGLSRMPKISGEEVVKIEREISTLADPYAFLKSIDPTIAFKIHPNDTYRIHKALEIFYATHTPPSEYFKANPKKPFEHAISLFALSIEKSTLHSNIKQRTKNMLHSGLVEEIKALYTQYPKDSQPFKAIGVKESILFLEKQLTLKELEEAIISNTMKLAKCQNTFNKTQFNNLYVGSVKEVRHAILNHSKSAIKG
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
Q1CRL4
P43184
BEV1K_BETPN
Allergen Bet v I-K
Betula
MGVFNYESETTSVIPAARLFKAFILEGDTLIPKVAPQAISSVENIEGNGGPGTIKKITFPEGSPFKYVKERVDEVDHANFKYSYSMIEGGALGDTLEKICNEIKIVATPDGGSILKISNKYHTKGDHEMKAEHMKAIKEKGEALLRAVESYLLAHSDAYN
May be a general steroid carrier protein.
P43184
Q96RU2
UBP28_HUMAN
Ubiquitin-specific-processing protease 28
Homo
MTAELQQDDAAGAADGHGSSCQMLLNQLREITGIQDPSFLHEALKASNGDITQAVSLLTDERVKEPSQDTVATEPSEVEGSAANKEVLAKVIDLTHDNKDDLQAAIALSLLESPKIQADGRDLNRMHEATSAETKRSKRKRCEVWGENPNPNDWRRVDGWPVGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSYSLPQNVLENCRSHTEKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRSSEEQQQDVSEFTHKLLDWLEDAFQLAVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFCNNETFGQYPLQV...
Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by ...
Q96RU2
Q9A0I6
ATPE_STRP1
F-ATPase epsilon subunit
Streptococcus
MTQMTVQVVTPDGIKYDHHAKFISVTTPDGEMGILPNHINLIAPLQVHEMKIRRGGEDEKVDWIAINGGIIEIKDNVVTIVADSAERDRDIDVSRAERAKLRAEREIAQAETTHNIDEVRRAKVALRRALNRINVSKK
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Q9A0I6
P45872
RF1_BACSU
Peptide chain release factor 1
Bacillus
MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQETVDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPKDPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKEIIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEKDIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARIYDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRI...
Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
P45872
P85420
VM11_BOTAT
Atroxlysin-I
Bothrops
TPEQQRYVDLFIVVDHGMFMKYNGNSDKIRRRIHQMVNIMKEAYSTMYIDILLTGVEIWSNKDLINVQPAAPQTLDSFGEWRKTDLLNRKSHDNAQLLTSTDFNGPTIGLAYVGSMCDPKRSTGVIQDHSEQDLMVAITMAHELGHNLGISHDTGSCSCGGYSCIMSPVLSHEPSKYFSDCSYIQCWDFIMKENPQCILNKR
Snake venom zinc metalloproteinase that acts on fibrinogen, fibrin, fibronectin (FN1), type I collagen, type IV collagen, integrin alpha-7/beta-1 (ITGA7/ITGB1) and integrin alpha-1/beta-1 (ITGA1/ITGB1). Binds to fibronectin (FN1), fibrinogen and, weakly, to type I collagen and laminin. Cleaves Xaa-Leu bonds. Inhibits A...
P85420
P14788
CYSA_SYNE7
Sulfate-transporting ATPase
Synechococcus
MPKDKAVGIQVSQVSKQFGSFQAVKDVDLTVETGSLVALLGPSGSGKSTLLRLIAGLEQPDSGRIFLTGRDATNESVRDRQIGFVFQHYALFKHLTVRKNIAFGLELRKHTKEKVRARVEELLELVQLTGLGDRYPSQLSGGQRQRVALARALAVQPQVLLLDEPFGALDAKVRKDLRSWLRKLHDEVHVTTVFVTHDQEEAMEVADQIVVMNHGKVEQIGSPAEIYDNPATPFVMSFIGPVNVLPNSSHIFQAGGLDTPHPEVFLRPHDIEIAIDPIPETVPARIDRIVHLGWEVQAEVRLEDGQVLVAHLPRDRYRDL...
Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system.
P14788
A0RPW8
GRPE_CAMFF
HSP-70 cofactor
Campylobacter
MSEDTNKNENVDNIPDNFDDNVSFTKLNEDVKDELALAKESLMRATADFENIKKRLEREKGEAVKFANESFARDLLPVIDALEIASNLQSGDDEIANKIKDGINLTIEQFKKCFEKYGIKEIRTDAEFNPEFHNAINYIESDEVESGKIAAVYQKGYLYNDRVLRPSMVVIAK
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-b...
A0RPW8
Q8BRJ4
PPR3E_MOUSE
Protein phosphatase 1 regulatory subunit 3E
Mus
MSPERPPRTDIPRNLSFIAALTERAYYRSQRPSLEEESEEEPGEGGTRPGARSRAHVPGRGRRARSAPAGGGGARTARSRSPDTRKRVRFADALGLELAVVRRFRPGEPPRVPRHVQVQLQRDALRHFAPCPPRARGLQEARVALEPALEPGFAARLQAQRICLERADAGPLGVAGSARVLDLAYEKRVSVRWSADGWRSLRESPASYAGPAPSPPRADRFAFRLPAPPVGGTLLFALRYRVTGREFWDNNGGRDYALLGPEHPAGAGAAEPQGWIHFI
Acts as a glycogen-targeting subunit for PP1. PP1 is involved in glycogen metabolism and contributes to the activation of glycogen synthase leading to an increase in glycogen synthesis.
Q8BRJ4
Q5B0D0
APTA_EMENI
Asperthecin synthesis protein A
Aspergillus subgen. Nidulantes
MKDNTHSTTLIFFGNEFPNDDLKGLFRCLLRLSKDRRFRQLAAFLEESTLVLKKEVAALPQPLRDLVPHFHTVLPLAELGDFRQGPLGAAMESALLTVLELGMFIGHYEAEGRDWNLLEHNTTLAGLSIGLLAAAGVALSTNLAEVAQNGAECVRVSFRLGVYVSEISRKLEAPQADGTLLSWAHVVTGETKSAIQDELSKYNSESGTPELLKVFISAADKTSVSVSGPPSRMKACFSSSHLLRYSKSFALPVYDGLCHASHLYNEDSINTVINSAESVIPVSRPVQLSLHSSNTGQPFPAATAHELFQAIGKELLTGTI...
Non-reducing polyketide synthase (NRPKS); part of the gene cluster that mediates the biosynthesis of asperthecin, an anthraquinone pigment . Catalyzes the formation of the aromatic polyketide from acetyl coenzyme A and seven malonyl coenzyme A molecules . Through its product template (PT) domain, catalyzes the cyclizat...
Q5B0D0
Q9Y6I4
UBP3_HUMAN
Ubiquitin-specific-processing protease 3
Homo
MECPHLSSSVCIAPDSAKFPNGSPSSWCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLTNHKKSEKQDKVQHTVCMDCSSYSTYCYRCDDFVVNDTKLGLVQKVREHLQNLENSAFTADRHKKRKLLENSTLNSKLLKVNGSTTAICATGLRNLGNTCFMNAILQSLSNIEQFCCYFKELPAVELRNGKTAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGILQN...
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Q9Y6I4
B6JCN2
AROA_AFIC5
5-enolpyruvylshikimate-3-phosphate synthase
Afipia
MSHASRPTPLEARGSTPLTGRVRVPGDKSISHRALILGALAVGETKITGLLEGEDVLNTAKAMAALGAKVERVGEGAWRVHGVGVGGFRAPDAPLDFGNSGTGCRLAMGAVAGSPIAATFDGDASLRSRPMRRILDPLELMGAKVSGGDGARLPLTLEGARDPIPMVYRTPVASAQIKSAVLLAGLSAPGETTVIEAEASRDHTERMLAQFGADIVTEPEGTHGRRITLTGQPELHGADVVVPADPSSAAFPIVAALIVPGSDLTLTDVMTNPLRTGLFTTLREMGASIEESDVRDAGEPMANLRVRASKLRGVTVPPER...
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
B6JCN2
Q3AQ22
DER_CHLCH
GTP-binding protein EngA
Chlorobium
MKPLLALVGRPNVGKSTLFNRILRQRSAIVDPTPGVTRDRHIAEGEWQGKQFKLMDTGGYNTDGDVLSKAMLEQTLHALADADSILFITDARAGLSYEDLELARILQRSFQHKQLFFVVNKVESPQLVIEAESFIKTGFTTPYFVSAKDGSGVADLLDDVLEALPEAPEGEVKGDTAVHLAIVGRPNVGKSSFVNALLGTNRHIVSNIPGTTRDAIDSRLMRNQQEYLLIDTAGLRKRTKIDAGIEYYSSLRSERAIERCEVAIVMLDAEQGIEKQDLKIINMAIERKKGVLLLVNKWDLIEKDSKTSIRYEEQLRMAMG...
GTPase that plays an essential role in the late steps of ribosome biogenesis.
Q3AQ22
C5CS25
AROC_VARPS
5-enolpyruvylshikimate-3-phosphate phospholyase
Variovorax
MSGNTFGTLFAVTNFGESHGPAIGCVIDGCPPGMELSEADIQGDLDRRRPGTSRHVTQRNEPDAVQILSGVYEGKTTGTPIALLIQNTDQRSKDYGQIAQQFRPGHADFTYWKKYGIRDPRGGGRSSARLTAPMVAAGAVAKKWLAEKYGMVFRGCMTQIGEIAIPFESWDHVPANPFFAPMADVSELEAYMDRLRKAGDSCGARIRVTAGNVPIGLGEPLFDKLDAEIAYAMMGINAVKAVEIGAGFESITQRGTTHGDSITPTGFVTNNAGGILGGISSGQDLEVSIAIKPTSSIISPRQSIDIHNNPVEVVTKGRHD...
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a s...
C5CS25
Q1M8E0
METN_RHIL3
Methionine import ATP-binding protein MetN
Rhizobium
MNSLVSTTAIEAQSQAAASEEVVRLTDVKRRFGTTAALDGISLTVKRGEILGIIGRSGAGKSTLIRCLNGLERADSGEILIEGRDITGLSEQELQPLRRRIGMIFQHFNLLSAKTVEENVALPLKIEGLAKSERLKRAHELLELVGLADKAKAYPASLSGGQKQRVGIARALAARPALLLSDEATSALDPETTRSILALLKDINRKLGLTILLITHEMEVVRGIADRVAVIDAGRIVEEGQVWSVFANPQAEITGSLLCGIRPQLPEHIAGRLSAAAGSEAILSVDLAGPQAQGALFAELSAALPHSFRLVHGGIDHIQN...
Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
Q1M8E0
A1KBP4
HBOH_AZOSB
D-(-)-3-hydroxybutyrate oligomer hydrolase
Azoarcus
MNPSLCIAVAFACPLSALAASGAPGVGFNEKPSFLGEIVQRSVDGVSDDLLTAGLGRDGIQSATPPLVSASPTATELRRLAIYNNYRALVDTTSGGGFGSLFGPLIAVDAGGRVSAPGDGKIAGTEYLAYAIDRGDDSKVTLMVQVPAHFNPKAPCIVTGTSSGSRGIYGAIGTSGEWGLQKGCAVAYADKGTGNGMHDLDTNTVGLIDGTRADAVAAGVASHFTADLTEAERTQFLASWPHRVAVKHAHSRANPEAHWGQDTLDAVRFAFFVLNETYGRRTPRGIVRTILPPNTVVIASSVSNGGGAALAAAEQDDERL...
Participates in the degradation of poly-3-hydroxybutyrate (PHB). It works downstream of poly(3-hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers.
A1KBP4
O47893
CYB_HYLME
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Hylobates
MTPLRKTNPLMKLINHSLIDLPAPSNISMWWNFGSLLGACLILQIVTGLFLAMHYTPDASTAFSSVAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYLETWNVGIILLLATMATALMGYVLPWGQMSFWGATVITNLLSAVPYIGTDLVQWVWGGYSVDNATLTRFFTFHFILPFIITALAALHLLFLHETGSNNPLGISSQPDKIAFHPYYTVKDILGLFLLLLMLMSLVLFSPDLLGDPDNYTQANPLNTPPHIKPEWYFLFAYAILRSVPNKLGGVLALLLSILILAMIPALHTAKQQSMMFRPL...
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is...
O47893
Q17WL9
SPEE_HELAH
Spermidine synthase
Helicobacter
MWITQEITPYLRKEYTIEAKLLDVRSDHNILEIFKSNDFGEIAMLNSQLLFKNFLHIESELLAHMGGCTKKELKEVLIVDGFDLELAHQLFKYDTHVDFVQADEKILDSFISFFPHFHGVKNNKNFTHAKQFLDLDIKKYDLIVCLQEPDKHKIDGLKRTLKEDGVFISVAKHPLLEHVSMQNALKNMGEFFSIVMPFVAPLRILSNKGYIYASLKTHPLKDLIAQKIEALKNVGYYNEDIHRAAFALPKNLQEILKENIKS
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
Q17WL9
Q98874
ERH_DANRE
Enhancer of rudimentary homolog
Danio
MSHTILLVQPTKRPEGRTYADYESVNECMEGVCKMYEEHLKRMNPNSPSITYDISQLFDFVDDLADLSCLVYRADTQTYQPYNKDWIKEKIYVLLRRQAQQAGK
May have a role in the cell cycle.
Q98874
Q0C9M9
EFG1P_ASPTN
rRNA-processing protein efg1
Aspergillus subgen. Circumdati
MPRDYSRSQSPVSNPTGDRNYRDRSDRPKRKDRDVSEDAPHHAYRKKIKIPKKEHPYPSVNELKKRIRDVKRLLNRVDLPADARIVQERALAGYENDLEEEMQRRHRSAMIKKYHFVRFLDRKTATKDVKRLERREQEVSKSDLDAVAKEKKLAALSQKLDIARVNLNYTIYYPLTEKYIALYAAVKKNKDGTTDGAADDSDVDAGYKLVHATREEKPAMWHVVEKCMKDGTLELLREGKLDTPDVDSTGKGSQKSKIDKHAQSKTDQTKSKSKKSEYKDTKHATKGKGRSVTSAASDENGDESDGGFFEM
Involved in rRNA processing.
Q0C9M9
Q5W915
USP_PEA
UDP-sugar pyrophospharylase
Pisum
MASSLGDNFNLLSPQQRELVKMLLDNGQDHLFRDWPNPGVDDDEKKAFFDQLVLLDSSYPGGLVAYINNAKRLLADSKAGNNPFDGFTPSVPTGETLKFGDENFNKYEEAGVREARRAAFVLVAGGLGERLGYNGIKVALPAETTTGTCFLQHYIESILALQEASSEGEGQTHIPFVIMTSDDTHGRTLDLLESNSYFGMQPTQVTLLKQEKVACLEDNDARLALDPQNRYRVQTKPHGHGDVHSLLHSSGILKVWYNAGLKWVLFFQDTNGLLFKAIPSALGVSSTKQYHVNSLAVPRKAKEAIGGITRLTHSDGRSMV...
May function as the terminal enzyme of the myo-inositol oxidation (MIO) pathway. May also play a role in the salvage pathway for synthesis of nucleotide sugars.
Q5W915
B3PWS2
RL4_RHIE6
50S ribosomal protein L4
Rhizobium
MELNVKTLEGKDAGKVSLSDAIFGLEPREDILARVIRWQLAKKQQGTHKAKGRAEVSRTGAKMYKQKGTGRARHHSARAPQFRGGGKAHGPVVRSHEHDLPKKVRALGLRHALSAKIKADDVIVIDNLVATEAKTKALASAFETLGLTNALFIGGAELDGNFKLAAQNIPNIDVLPIQGINVYDIVRRGKLVLSKAAVEALEERFK
Forms part of the polypeptide exit tunnel.
B3PWS2
Q6L8G1
IRT2_ORYSJ
Iron-regulated transporter 2
Oryza sativa
MMMSSSQTPVRIAFVFLVILAATDAHSDHRTPPPACGGAAVGGECHSVARALRLKLIAIPAILAASVAGVCLPLFARSVPALRPDGGLFAVVKAFASGVILGTGYMHVLPDSFNDLTSPCLPRKPWSEFPFAAFVAMLAAVFTLMVDSLMLTFHTRGSKGRASSAVAHHGDHGHCHAHALGQADVAALSTTEAADQGSGDVEAGNTTKAQLLRNRVIVQVLEMGIVVHSVVIGLGMGASQNVCTIRPLVAALCFHQMFEGMGLGGCILQAGYGGRTRSALVFFFSTTTPFGIALGLALTRVYSDSSPTALVVVGLLNAAS...
Iron transporter that may play a role in the uptake of iron from the rhizosphere across the plasma membrane in the root epidermal layer.
Q6L8G1
Q9WVR6
LAT2_RAT
Solute carrier family 7 member 8
Rattus
MEKGTRQRNNTAKNHPDRGSDTSPEAEASSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGVITAVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGVVQICKGEFFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANIAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMP...
Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affi...
Q9WVR6
C0HLA3
VSP4_LACMR
Snake venom serine protease LmrSP-4
Lachesis
VFGGDECNINEHRSLVVLFDSDGFLCAGTLINKEWVLTAAHCDSENFQMQLGV
Snake venom serine protease that has fibrinogenolytic activity. Hydrolyzes the alpha-chain of fibrinogen (FGA), without affecting the beta- and the gamma-chains. Also displays hydrolytic activity towards S-2302 (plasma kallikrein substrate) and S-2251 (substrate for plasmin), but has no hydrolytic activity with S-2238 ...
C0HLA3
A1K782
CLPX_AZOSB
ATP-dependent Clp protease ATP-binding subunit ClpX
Azoarcus
MTEKKTGGEKLLYCSFCGKSQHEVRKLIAGPSVFICDECIELCNDIIRDEIAGSVETEGVKGKLPTPHEICQILDQYVIGQAQAKRNLSVAVYNHYKRLRHLSGRQDEVELSKSNILLIGPTGSGKTLLAQTLARLLNVPFVMADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQQGIVYIDEIDKISRKSDNPSITRDVSGEGVQQALLKLIEGTIASIPPQGGRKHPNQDFIQVDTTNVLFICGGAFDGLDKVIRNRTEKMGIGFGAEVKSRQGKNLTETFRQVEPEDLVKFGLIPEFVGRLPVVATLQELDEDA...
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
A1K782
Q9RW02
FOLD_DEIRA
Methenyltetrahydrofolate cyclohydrolase
Deinococcus
MQTSSEPAASETAALLGKPLADRVMRGVRADLKAWAQLDPPFEPQLVSVLASDDEASQVYVQSKAKRAKKLGVAFRVVDLGAAATQEALEQTLRELSADPAVHGIVLELPLAAGLDADAALLHIAARKDIEGLSPANLALIAAGREPEALLPPTPRSVRFLLRHALGDDLRGLRVAVIGPGRTVGRPLLFMLNNKGATVTLCNEHTRDLAAVLAAQDAVVVAVGKAGLLRPEQVQPEHVVIDAGINVQESGDMVGDALPELPVRAQTPVPGGVGPLTSALMYQNLVRGVKLQRGEPVDD
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Q9RW02
Q04V79
COAX_LEPBJ
Pantothenic acid kinase
Leptospira
MLLVVDVGNTNTVFGIFENGKNVPLFHKRTVTRKDRTSDELGLFFRGFLREFKIENEAITGGIYSSVVPTLNPILERMFQDWFKIEAIRVHYQMKLPFSISYPRPYEIGADRLVNAAACVIDSPGKFIIIDLGTATTFCVVSEKPEYLGGVIAPGLKVSMDALTRNTSQLPPIVFQSPEKILGDSTIESIQAGFFFGWIGLLEGIIREIKKDKGQDYRVIGTGGLVTVIDAAHPGIFDKIDPLLTLRGLQILHQMNS
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
Q04V79
P86080
E13B_CAPAA
Beta-1,3-endoglucanase, basic
Capsicum
GSNIEVMLGLPNSDVK
Implicated in the defense of plants against pathogens.
P86080
Q0SNB5
RL1_BORAP
50S ribosomal protein L1
Borreliella
MSKKGKKYIEAFSKVDKSKFYSIEDAISLLKEIKFVKFDETIDISVNLNLKKNHTVRDTIVLPNQFMKPKRILVFAKGDRADEARAFGATYVGDDDLINKIKSGWDEFDIVVATPDMMKDVGRLGPILGKRGLMPNPKTQTVTNNLKDAINSLKKGRTEFRANKNGVISFSFGKSSMDNEKIKENYEEFIKEVVKKRPSDLKGTFIDSIYISSTMGPSIRVEFVWR
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
Q0SNB5
Q9N491
SQV2_CAEEL
Squashed vulva protein 2
Caenorhabditis
MRFYRTYLLVAGAFCSLCTLAVIFNCGWDDSPPATPSAINGGGSNAPLISSPTNLPETFLYISILTSPNETERRQNVRDTWFRLSTKGPSVFIAKFAVGTMGLAAEDRRLLAEENEKFGDLALLDRHEESYERLAKKTLACFVHAFANFKFKFFLKTDIDSFVRITPLIINLKQIQDPMLYWGFLDGRAKPFRKGKWKEPEWNLCDRYLPYQLGGGYVLSYELIRFLAINAQLFRHYRNEDVSVGAWIGGLDVKYVHDPRFDTEWRSRGCNNEYLITHKHTEQEMQEMFENLKKTGKLCAKEFQKHPSYVYDFSKAPSEC...
Beta-1,3-galactosyltransferase that transfers galactose from UDP-galactose to substrates with a terminal beta-linked galactose residue. Required for vulval morphogenesis and zygotic cytokinesis, suggesting that glycosaminoglycans play a central role in vulval morphogenesis.
Q9N491
P0CF61
INSD9_ECOLI
Transposase InsD for insertion element IS2-9
Escherichia
MWTGKKVDSARALIARGWGVSLVSRCLRVSRAQLHVILRRTDDWMDGRRSRHTDDTDVLLRIHHVIGELPTYGYRRVWALLRRQAELDGMPAINAKRVYRIMRQNALLLERKPAVPPSKRAHTGRVAVKESNQRWCSDGFEFCCDNGERLRVTFALDCCDREALHWAVTTGGFNSETVQDVMLGAVERRFGNDLPSSPVEWLTDNGSCYRANETRQFARMLGLEPKNTAVRSPESNGIAESFVKTIKRDYISIMPKPDGLTAAKNLAEAFEHYNEWHPHSALGYRSPREYLRQRACNGLSDNRCLEI
Involved in the transposition of the insertion sequence IS2.
P0CF61
B0TE72
RS6_HELMI
30S ribosomal protein S6
Heliomicrobium
MREYEAVVLVRPNLEEEALQGVIDKFVNLVPQQGGEVVKVDKWGKRRLQYEVKKFKEAFYFLLNFKGEPAVAQELERVMKISDDIIRFLVVRKDEQ
Binds together with S18 to 16S ribosomal RNA.
B0TE72
Q1IFE4
ADE_PSEE4
Adenine aminohydrolase
Pseudomonas
MYEWLNALPKAELHMHLEGSLEPELLFALAERNKIALPWADVETLRGAYAFNNLQEFLDLYYQGADVLRTEQDFYDLTWAYLQRCKAQNVIHTEPFFDPQTHTDRGIPFEVVLGGITQALKDGREQLGIGSGLILSFLRHLSEDEAQKTLDQALPFRDAFVAVGLDSSEKGHPPSKFQRVFDRARSEGFLTVAHAGEEGPPEYIWEAIDLLKIQRIDHGVRAIEDERLMQRIIDEQIPLTVCPLSNTKLCVFEHMSQHNILDMLERGVKVTVNSDDPAYFGGYVTENFHALYEHLGMTQDQARRLAQNSLDARLVR
Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.
Q1IFE4