accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
P21744
IBP4_RAT
Insulin-like growth factor-binding protein 4
Rattus
MLPFGLVAALLLAAGPRPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGMRCYPPRGVEKPLRTLMHGQGVCTELSEIEAIQESLQTSDKDESEHPNNSFNPCSAHDHRCLQKHMAKVRDRSKMKVVGTPREEPRPVPQGSCQSELHRALERLAASQSRTHEDLFIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSLQE
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
P21744
Q28851
ATPK_BOVIN
ATP synthase membrane subunit f
Bos
MASVVPLKEKKLLEVKLGELPSWILMRDFTPSGIAGAFQRGYYRYYNKYVNVKKGSIAGLSMVLAAYVFLNYCRSYKELKHERLRKYH
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous ca...
Q28851
Q39033
PLCD2_ARATH
Phosphoinositide phospholipase PLC2
Arabidopsis
MSKQTYKVCFCFRRRFRYTASEAPREIKTIFEKYSENGVMTVDHLHRFLIDVQKQDKATREDAQSIINSASSLLHRNGLHLDAFFKYLFGDNNPPLALHKVHHDMDAPISHYFIFTGHNSYLTGNQLSSDCSEVPIIDALKKGVRVIELDIWPNSNKDDIDVLHGMTLTTPVGLIKCLKAIRAHAFDVSDYPVVVTLEDHLTPDLQSKVAEMVTEIFGEILFTPPVGESLKEFPSPNSLKRRIIISTKPPKEYKEGKDVEVVQKGKDLGDEEVWGREVPSFIQRNKSEAKDDLDGNDDDDDDDDEDKSKINAPPQYKHLI...
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. At physiological calcium concentration, the preferred substrate is phosphatidylinositol 4,5-bisphosphate versus phosphatidylinosito...
Q39033
P54542
YQJE_BACSU
Uncharacterized protein YqjE
Bacillus
MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKEDDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTILGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGYALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRIDEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGGRAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGG...
Could be a peptidase.
P54542
B8IMM9
YIDC_METNO
Membrane protein YidC
Methylobacterium
MGNDKTNMIIAIALSLAVLLGWNYFVAAPQVERQRQQQAQTSASPSPKEGGPSAPVPGTLPGASGGNPQAALTREEALARSPRVRIDTEALKGSVALKGGRIDDVALKGYHETVDPKSPEIVLLSPAGSANPYYAEFGWVGQGAGPLPNGDTVWTADGDLLTAKKPLTLTWDNGAGLVFRRTLSVDDKYMFTVEDSVENKGQSAVTLYPYGLVSRWGKPHTQGYYVLHEGLIGVLGDKGLQEYTYDKMAKENPLGSPGTRGLSWPGVTGGFLGITDKYWAAATIPDQKTPYTGSFTERDEGATKVYQTSSLGEARTLAPG...
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning memb...
B8IMM9
B0BS66
RDGC_ACTPJ
Recombination-associated protein RdgC
Actinobacillus
MFWFKNVMIYRLTSPLSLESSSLEEQLQQAKFTPCSQSDMSKFGWSSPLSGSELLHFSQGKQFLLVSHKEDKLLPANVIKKETEERIAVLEEKEARKLKKTEKQAIKDDVVAMLLPRAFSKHQFTAIWLDLDAQLVYVDAGSSKRAEDTLALLRKTLGSLPVVPISFALLPSEVMTNWIAKGHTPNWLNLLEEAELKSFDTDSVIRCKRQDLESEEIAQHLQAGKFVTKLAIDWENHFSCVLNEDATLSRVKFADEVREKNDDILKEDIAQRFDADFLLMTEELKLFTQKMIEEFGGIKERI
May be involved in recombination.
B0BS66
Q2YSD3
SYE_STAAB
Glutamyl-tRNA synthetase
Staphylococcus
MSDRIRVRYAPSPTGYLHIGNARTALFNYLYAKHYNGDFVIRIEDTDKKRNLEDGETSQFDNLKWLGLDWDESVDKDNGYGPYRQSERQHIYQPLIDQLLAEDKAYKCYMTEEELEVEREAQIARGEMPRYGGQHAHLTEEQRQQFEAEGRQPSIRFRVPQNQTYSFDDMVKGNISFDSNGIGDWVIVKKDGIPTYNFAVAIDDHYMEISDVIRGDDHISNTPKQIMIYEAFGWEPPRFGHMSLIVNEERKKLSKRDGQILQFIEQYRDLGYLPEALFNFIALLGWSPEGEEEIFSKEEFIKIFDEKRLSKSPAFFDKQK...
Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).
Q2YSD3
B9MRJ1
HEM1_CALBD
Glutamyl-tRNA reductase
Caldicellulosiruptor
MLWVIGINHKVEVDIRQKFSLIKTKLQEKLISLKKLANEVIILSTCNRTEIYFFSEEYVDIEKIFTELDWDKRYMHLFYIYKDKDCIKHLFEVVCGFDSLLIGEDQIVAQVKEAKEISKLVGGKNPVLERLFEVALKCSKEFRTKARLNEHPITIASVVGKVLKESNIRKIAIIGLGNIGILFCNYFKNSDVDKVFLIGRKNEKIDQFVKLNPEKFRYYDKKKTILEAQCLICSTSAPHSVVHKDDIPEGKNLLIFDLAVPRDVDVEVYELPNVKVIDIDQVHKIDTINREFRISKMQENYHIIDKYVDEFIDWLEFRQY...
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
B9MRJ1
B2IH14
RNPH_BEII9
tRNA nucleotidyltransferase
Beijerinckia
MRPSKRAAQDLRPVTLERNVARYAEGSCLVKFGGTHVLCTASLEDKPPPWLRGQGRGWVTAEYAMLPRATHTRTRRESMSGKPSGRTQEIQRLIGRSLRAVTNLPALGERQITLDCDVLQADGGTRTAAITGAWVALHDCCKWMHGRSIIKEFPLREHVAAVSCGIYQGEAVLDLDYEEDSVAQTDANFVMTGGGALVEVQASAEGAVFSEDELSVLLALAKGGIAQLVNIQKLAIG
Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably p...
B2IH14
B1YNM7
LIPB_BURA4
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Burkholderia cepacia complex
MSVSPVPIVSTPVAVSESPAGSPVQPAVPVTVRWRGSEAYETSFDAMRAFTDTRTADTGDEIWVVEHPPVYTLGQAGDPAHLLVADSGVPLVKVDRGGQITYHGPGQIVVYLLLDLRRRKLMVRTLVTKIEEAVIETLAAYNLASVRKAGAPGIYVASGVHEGAKIAALGLKIRNGCSYHGLSLNVKMDLRPFLAINPCGYAGLETVDMASLEVAADWNDVAHTLVGRLIANLDGESAAADKPQALEHSND
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
B1YNM7
G3DT18
PA2A_BOTMO
Phosphatidylcholine 2-acylhydrolase
Bothrops
MRTLWIVAVLLLGVEGNLWQFEMLIMKIAKTSGFLFYSSYGCYCGWGGHGRPQDATDRCCFVHDCCYGKVTGCNPKTDSYTYSEENGDVVCGGDDPCKKQICECDRVAATCFRDNKDTYDNKYWFYPAKNCQEESEPC
Snake venom phospholipase A2 (PLA2) that inhibits ADP- and collagen-induced platelet aggregation, has edema-inducing, anti-coagulant activity, antibacterial activity, and cytotoxic activity. In vivo, has a hypotensive effect. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides...
G3DT18
Q184H7
UPPP2_CLOD6
Undecaprenyl pyrophosphate phosphatase 2
Clostridioides
MMSLDVIFILKSVIIAIVEGLTEFIPVSSTGHMILVGNLIDFKGQFAEMFEVVIQLGAILAVVVLYWKKIKDSVIEFFKFIFTGGKEGKIGFRFGMNVIIGCIPFAIIGVLFYDNIKSLFNLQSVIIGFIVGGILLLVVETLFRKKNHSTDNIDKITPIQALKVGTLQVLSAWPGMSRSASTIMGGWIAGLNSPTAAEFSFFLAVPAMVASSGKDLFEFDYSIMTPTLWIALVVGFIVAFIVSIIVMEKFVNFLKKKPMRVFAVYRIIMGVVLAVLAFTNIISV
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Q184H7
B0K0V5
ARGR_THEPX
Arginine repressor
unclassified Thermoanaerobacter
MKIARHAKILEIISEKEIETQEELAAELQKQGIDVTQATVSRDIKELRLIKVLTEDGKRYKYAPMGKVDGHITDRLMTLLSESIVSVDYAGNIIVIKTLSGTAPAAAEAIDTLNWKNIVGTLAGDNTIFVLVRNEEALQELLEKFKKLVK
Regulates arginine biosynthesis genes.
B0K0V5
P40420
GLCU_BACSU
Glucose uptake protein GlcU
Bacillus
MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIVIYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLFGVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVSTLGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAGGNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAAAVFLGIAKTNS
Involved in the uptake of glucose.
P40420
Q9YGP1
LECG_TRIST
Galactose-binding lectin
Trimeresurus
MGRFIFVSFGLLVVFLSLSGAKGSCCTNDSLPMNGMCYKIFDEPKTWEDAEMFCRKYKPGCHLASFHRLAESLDIAEYISDYHKRQAEVWIGLLDRKKDFSWEWTDRSCTDYLNWDKNQPDHYKDKEFCVELVSLTGYHRWNDQVCESKNSFLCQCKF
Galactose-binding protein which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids. May be a calcium-dependent lectin.
Q9YGP1
P59060
RS7_CHLTE
30S ribosomal protein S7
Chlorobaculum
MAKKGSGYGPRGGDFRYNDEAVARLINAIMLDGKKVVATKIVYDAFDIIANKVEGGDALEVFRKAMGNVAPLVEVRSKRVGGATYQIPMEVPASRRTALAFRWIKQFAARRGGRSMAEKLAAELLDASNEQGASVKKRDEVHRMAEANKAFAHFRF
One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.
P59060
P57443
PYRD_BUCAI
Dihydroorotate oxidase
Buchnera
MFYYFIRKLLFLLEPEKAHFLTLKYLNIKNIQFFDFFFYKTIILSKKIKCMGLIFDNKLGTAAGIDKNGEYIDALSKLGFGFIEVGTVTPLPQVGNPKPRMFRIVSMEGIINRMGFNNLGIDNLIRNIKKSNFKGIIGVNIGKNKSTSLENSVDDYLICIEKIYCYAGYIAINISSPNTTNLRNLQYGILFKKLLYKIKKKQKELHKKYLKYVPIAIKISPDLSIKELVDISKQLIRYKIDAVIATNTTLDHSSLFGLKNSSEQGGLSGLPLQKKSTNTISILSKSLQKKIPIIGVGGINSINSAKEKIESGATLIQIYS...
Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
P57443
Q9MBD8
BI1_ORYSJ
OsBI-1
Oryza sativa
MDAFYSTSSAYGAAASGWGYDSLKNFRQISPAVQSHLKLVYLTLCVALAASAVGAYLHVALNIGGMLTMLGCVGSIAWLFSVPVFEERKRFGILLAAALLEGASVGPLIKLAVDFDSSILVTAFVGTAIAFGCFTCAAIVAKRREYLYLGGLLSSGLSILLWLQFAASIFGHSTGSFMFEVYFGLLIFLGYMVYDTQEIIERAHHGDMDYIKHALTLFTDFVAVLVRILVIMLKNASDKSEEKKRKKRS
Suppressor of apoptosis.
Q9MBD8
A5GWT8
QUEC_SYNR3
Queuosine biosynthesis protein QueC
unclassified Synechococcus
MSSTTIALLSGGLDSATAAALAREAGHRVIGLSFDYGQRHQRELRAAAEVAQALGLAEHHTINVNLAAWGGSSLTDLDQPVPDQGVQDGVIPSTYVPGRNTVFIALGLSLAEAKGAERLVLGVNAIDYSGYPDCRPDYLDAYQHLADLASRSGREGHGTQLWAPLVEWSKTKIVEEALRLNVPIASTWSCYAGGDHPCGVCDSCRIRDAALREAGRPDLASR
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
A5GWT8
P70047
MYT1_XENLA
Myelin transcription factor 1
Xenopus
MNVDNVNKGTHTRSKASRVIPSDLIEQEVSLESCPLSRKRKLQESEQENPLSKRKSHPLKLALDEGFNVDSNGSEETEMKERDSGTEESEATLEEIEEDSEPTKPKEAPSPQTAEAESSDKVEPEETETKTESSPPAKATYSSYHEIIANSLLNLGQVAKEALVSEGHLKESELNNEKPTSVKSGQAEIEQLMVEEACEKEIIIQTEDAEEVIEVTSEPISESGTEPRDEVNCEDTEKLQKDMIDEEEEEEDDDVDEEDDDDLEEDEEEEEEHSSEMANQDLPHASQDSPKPHCEGHFSPKPEYSVIVEVRSDDDKDDDS...
Transcriptional activator which is essential for neuronal differentiation. Can promote ectotopic neuronal differentiation and confers insensitivity to lateral inhibition, but only in cooperation with bHLH transcription factors.
P70047
P08908
5HT1A_HUMAN
Serotonin receptor 1A
Homo
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPAS...
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such a...
P08908
Q3AHW4
RIMP_SYNSC
Ribosome maturation factor RimP
unclassified Synechococcus
MPHPLLPDLETLATKVAASKGFALCGIQLLTHMSPMTLEVQIRHSSGADVSLDDCAGFSGVLGDALEASTLLTDAYVLEISSPGIGDQLSSDRDFETFRGFPVEVHHRDKDDSEQRLEGLLLERDADTLQINIRGRIKRIARDCVIGVRLTSPGS
Required for maturation of 30S ribosomal subunits.
Q3AHW4
Q4A5P7
RLMH_MYCS5
rRNA (pseudouridine-N3-)-methyltransferase RlmH
Mycoplasmopsis
MTINLIAVGKLEKDFQKLFDEYAKRIFVFSKFNLIEIKENTLKNLEVKKEKETLEILSKIPKNSTVFLLSIKGKNYSSEEFSKLITNDANITFVIGGSNGVIESYFENKISFSKLTFPHQLFRVILIEQIYRAFTIKNNLKYHK
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
Q4A5P7
B2UBB5
RNH2_RALPJ
Ribonuclease HII
Ralstonia
MASRKPNPDQLGLLLSQEPAAKRARRILCGVDEAGRGPLAGPVTAAAVVLNPRKPIKGLADSKILTARKREALYDEIVEKALAWHVAEATVEEIDRINILHATMLAMQRAVQGVAALGTLPDLVQVDGNRCPQVAFAVEAIVKGDALVPAISAASILAKVTRDRQLAALHIEFPLYGFDVHAGYGTPQHLAAIDLHGVTPHHRRSFAPVRRALEGMSAISIETVAAGSAWDD
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
B2UBB5
O32720
SP2AA_PAEPO
Stage II sporulation protein AA
Paenibacillus
MNLQIEMEHHRGVLIVRLSGELDHHTSDMVRMQMDEAIQRRQCEHIVLSLKNLQFMDSSGLGVILGRYKLINQKGGEMAVCDVNPPVHRLLDMSGLFKIMPIYDNEVNALTELEVVS
In the phosphorylated form it could act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma f from inhibition.
O32720
Q1WSB9
ECFA2_LIGS1
Energy-coupling factor transporter ATP-binding protein EcfA2
Ligilactobacillus
MSIQAKKLNYTYQIGTPLEHIALKDVSINIKDGSYTAIVGHTGSGKSTLLQHLNGLLKPTSGEISINGYTIDNTTKNKELGKLRKEVGFVFQFPEAQLFEETVLKDIAFAPKNFGKSEDEAEKIAREKAKLVALPEEVLEKSPFELSGGQMRRVAIAGILAMEPKVLVLDEPTAGLDPEGRHQMMEMFNRLHKDENLTIILVTHQMNDVAEYADHVIVLESGKVIADSTPKELFSDPEWLKNHHLNLPQTTDFAYKLFDKLALSKHSLPLKSEELTDEILKILGGNLNE
ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
Q1WSB9
A1SLJ4
PNP_NOCSJ
Polynucleotide phosphorylase
Nocardioides
MTDPEISAVETVLDNGKFGTRTVKFETGLLARQAAGAVTAYLDEDTMLLSATTAGKHPKDHFDFFPLTIDVEERMYAAGKIPGSFFRSEGRPGEDAILTCRLIDRPLRPTFKKGLRNEVQVVITVMALNPDTPYDVLAINAASLSTQLSGLPFSGPVGGVRVALIEGQWVAFPTHSQLENAVFDMVVAGRVTETGDVAIMMVEAEATEQTWDLVRSGTQAPTEEIVAGGLDAAKPFIKQLCEAQVELANVAAKPVQDFPVFLDYEDDVYDAVEAAVKAELAAAMKIADKQERNDRTDELKDEVLAKLGEQFEGREKEIGA...
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
A1SLJ4
P17622
RIBT_BACSU
Protein RibT
Bacillus
MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQLFLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPNELTQSFFERCQGQQDQDISYNN
Involved in riboflavin biosynthesis.
P17622
P43858
TRPD_HAEIN
Anthranilate phosphoribosyltransferase
Haemophilus
MQHNQLLEQLYSGHSLSTSESTALFNAVIQGELSNEQIAAMLIALKVRGANTEEISGAVAASLQNAKAFPYPNYPFADIVGTGGNGQNTINISTTSAIVAASMGAKIAKHGNRSVSSKSGASDVLTALSVNVNVTPEQARQALDEIGVCFLFAQQYHSGFRHVAPVRAALKTRTIFNILGPLINPARPTYHLLGVYAPELVKTYAETAVALEHQHSFVVHGSGLDEVALHGETQVAEIKNGKIEYFTLTPEDFGLKTQSLESLRGGEPQENAQYLTALLQGKGKAEHANAVAANTALLLKLFGYDDLKQNVQNVLAHLVS...
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
P43858
Q87AC5
EX7L_XYLFT
Exodeoxyribonuclease VII large subunit
Xylella
MQHRDEILTPSQLNTLARDLLESAFPLVWIEGELGNVSRPSSGHLYVTLKDAQAQVRCAMFKPKSQWLTFQPREGLRVLARGRLTLYEARGDYQIVLDHLEESGEGALRRAFEQLRIRLEAEGLFDPARKQPLPVHPRRIAVITSPSGAVIRDILSVLMRRFPLVEIELLPSLVQGDTAAAQITHLLGGADSSGRYDAILIARGGGSLEDLWAFNNEQLARTIAAAHTPVISAIGHETDFTLADFAADIRAPTPSVAAELLVPDQRALRQHLGQLQQRLLHLQQHRLDQAIQRADQLGLRLQARNPEMHLRLLAQRQAEA...
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
Q87AC5
Q43629
ARC4_PHAVU
Arcelin-4
Phaseolus
MGSSKLLSLALLLVLLTHANSASETSFNFTSFDTNKLILQGDASVSSKGQLLLTKVRGNGDPTVDSMGRAFYYAPIQIRDSTTGKLASFDTNFTFSIRPYSNNENSAFGLAFALVPVDSEPKRKDYFLGLFNKPDDPEAHIVAVVFDTSSNQIEIDMNSISPVARESCHFHKYNGEKVEVRITYDSSKKNLRASLVYLREQSATSSTSSVHMEKVLNDWVSVGFSATSGLYDPTSETHDVLSWSFSSKFSQHTTSERSNFLLNMFL
Seed storage. This carbohydrate-binding lectin has toxic effects on the important bean bruchid pests, Z.subfasciatus and A.obtectus.
Q43629
Q9WTN5
TPC1_RAT
Voltage-dependent calcium channel protein TPC1
Rattus
MSVILDDDVLLILTLDEELSAPLTPSNGLGQEDLPSKNGGGQSGPNSQVPSLVSGADSPPSSPPGHNWEMNYQEAAIYLQEGQNNDKFFTHPKDARALAAYLFVHNHFFYMMELLTALLLLLLSLCESPAVPALKLRTYVHATLELFALMVVVFELCMKLRWLGFHTFVRHKRTMVKTSVLVVQFIEAIVVLVRQTSHVRVTRALRCIFLVDCRYCGGVRRNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLFSTNPSDPYFNTLENSIVNLFVLLTTANFPDVMMPSYSRNPWSCVFFIVYLSIELYFIMNLLLAVV...
Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confe...
Q9WTN5
B2V8P5
IXTPA_SULSY
Nucleoside-triphosphate pyrophosphatase
unclassified Sulfurihydrogenibium
MKILLATTNEGKVRELRQLLKDLDIEILSLKDMDKKLEVEEDKETFLENAIKKATSYAKFYKLPVIAEDSGLEVDALNGLPGIYSARFFDIEFGKEVLKEIPENLSKDEKNNLKLLRLLENQTNRKARYKTALVFYNFDYGIWTEGVCEGQIAYKPEGNQGFGYDPIFIPEGYNKTMAQLTPEEKNKISHRGKAVSKLVEILKKVL
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical p...
B2V8P5
B4SA80
NTPPA_PELPB
Nucleotide pyrophosphatase
Pelodictyon
MGKPALILASQSPRRRDILSLTLIPFETMAIETRETLDPTSSIEENVTKIALEKAECAAALLPKQNGKTIILTADTVVAKGNRIYGKPAGFDEAFEMLKSLQNRSHRVYTGFVLLCCDKIHTECVTTTVELEPMSDNEIKRYILSEKPYDKAGSYGIQDPLMACYIRRIEGCYHNVVGLPLSRVCKALKTFL
Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
B4SA80
Q7NA95
ATPE_PHOLL
F-ATPase epsilon subunit
Photorhabdus
MAAMTYHLNVVSAESRMFEGLVQKIQVTGSEGELGIYPGHAPLLTAIKPGMVRIVKQFGEEEVIYLSGGILEVQPSGVIVLADTAIRGKDLDEAKALESKRKAEEHIRNSHGDVDYAQASAELSKAIAKLRVIELTKKAM
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Q7NA95
A1T7L4
PNP_MYCVP
Polynucleotide phosphorylase
Mycolicibacterium
MSVVEIEDGVFESTATIDNGSFGTRTIRFEAGRLAQQAAGAVVAYLDDETMLLSATTASKSPKEHFDFFPLTIDVEERMYAAGRIPGSFFRREGRPSTDAILTCRLIDRPLRPSFVSGLRNEIQVVVTVLSLDPKDLYDVLAINAASASTQISGLPFSGPVGGVRVALIDGQWVAFPTVEQLERAVFDMVVAGRKVGDDHKDVAIMMVEAEATENVIELVAGGAGAPTETVVAEGLEAAKPFIAVLCDAQAALAGAAGKETAEYPLFPDYGDDVYYSVASVATEALSEALTIAGKNERNDRTDEIKVEVLNRLAEQYAGR...
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
A1T7L4
B4TVU1
PLSY_SALSV
Lysophosphatidic acid synthase
Salmonella
MSAIAPGMILFAYLCGSISSAILVCRIAGLPDPRESGSGNPGATNVLRIGGKGAAVAVLIFDILKGMLPVWGAYALGVTPFWLGLIAIAACLGHIWPVFFGFKGGKGVATAFGAIAPIGWDLTGVMAGTWLLTVLLSGYSSLGAIVSALIAPFYVWWFKPQFTFPVSMLSCLILLRHHDNIQRLWRRQETKIWTKLKKKRQKDSE
Catalyzes the transfer of an acyl group from acyl-ACP to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme can also utilize acyl-CoA as fatty acyl donor, but not acyl-PO(4).
B4TVU1
A5A6I3
EIF3F_PANTR
eIF3 p47
Pan
MATPAVPVSAPPATPAPVPAAAPVSAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAATTAAPGQTPASAQAPAQTPAPALPGPALPGPFPGGRVVRLHPVILASIVDSYERRNEGAARVIGTLLGTVDKHSVEVTNCFSVPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPNPIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMKTCFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQVP...
Deubiquitinates activated NOTCH1, promoting its nuclear import, thereby acting as a positive regulator of Notch signaling.
A5A6I3
B2SC28
UPPP_BRUA1
Undecaprenyl pyrophosphate phosphatase
Brucella
MDFFNLLEAAFLGLIEGLTEFIPVSSTGHLLLIGHFLGFESTGKTFEVLIQLGAILAILSVYSAKLARIATDFPRDARTRRFVLGVLVAFLPAAVIGALAHGFIKGVLFETPMLVCIMLIVGGFILLWVDQLNLRPRYHNVMDYPLPICLAIGFIQCLAMIPGVSRSGSTIVGSLLLGADKRSAAEFSFFLAMPTMAGAFAYDLFKSRNILSFNDGALIVVGFIMAFISGVFVVRHLLDYVSRHGFALFGWWRLIVGSAGMAALIIWG
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
B2SC28
Q1AXT0
GATA_RUBXD
Glutamyl-tRNA(Gln) amidotransferase subunit A
Rubrobacter
MLELSAFELAERVLAREVSASEAAAAANARVEEVEGDLNSFITGTPELALERAARVDERLRRGEEVRPWECVPIAVKDVLSTRGVRTTCGSRILENFEPVYEASALLSFGPDPIMVGKANMDEFAMGSSTENSAYGPTRNPWDLSRVPGGSSGGSAAAVAAGQGWWALGTDTGGSVRQPASFCGLVGLKPTYGRVSRYGLIAFASSLDQIGPMTRDVRDAALLLQAIAGHDPKDSTSAGVEVPDYLSGLERGVEGLRVGIVRELVEAEGVEGEVREISLRTARALEEAGARVGEVSLPHAGYGLPAYYIIAPAEVSSNLA...
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Q1AXT0
B6YW69
IF2G_THEON
eIF-2-gamma
Thermococcus
MAKKKEFRQAEVNIGMVGHVDHGKTTLTKALTGIWTDTHSEELRRGITIKIGFADAEIRKCPSCGRYSTSPICPYCGHETEFERRVSFIDAPGHEALMTTMLAGASLMDGAVLVIAANEGVMPQTREHLMALQIVGNKNIVIALNKIELVDREKVIERYQEIKEFVKGTVAENAPIIPISALHGANVDVLLAAIEEFIPTPEHDPNKPPKMLVLRSFDVNKPGTKPEKLVGGVIGGSIVQGKLKVGDEIEIRPGVPYEEHGRIKYEPITTEIVSLQAGGRFVEEAYPGGLVGVGTKLDPYLTKGDLMAGNVVGKPGQLPP...
eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.
B6YW69
Q9D6Y9
GLGB_MOUSE
Glycogen-branching enzyme
Mus
MAAPAAPAAGETGPDARLEAALADVPELARLLEIDPYLKPFAADFQRRYKKFSQVLHDIGENEGGIDKFSRGYESFGIHRCSDGGIYCKEWAPGAEGVFLTGEFSGWNPFSHPYKKLEYGKWELYIPPKQNKSPLIPHGSKLKVVITSKSGEILYRISPWAKYVVRENNNVNYDWIHWAPEDPYKFKHSRPKKPRSLRIYESHVGISSHEGKIASYKHFTSNVLPRIKDLGYNCIQLMAIMEHAYYASFGYQITSFFAASSRYGTPEELKELVDTAHSMGIVVLLDVVHSHASKNSEDGLNMFDGTDSCYFHSGPRGTHD...
Required for normal glycogen accumulation. The alpha 1-6 branches of glycogen play an important role in increasing the solubility of the molecule.
Q9D6Y9
Q6PD99
MRPA_DANRE
MARCKS-like protein 1-B
Danio
MGAQLTKGEATVEGKAVADKANGQENGHVKTNGDVSTKPDGEAVAADGNGTAEVAKDEAPKTEEGDGIEAAPATEAEASKSDGEAAKETKKKKKFSLKNSFKFKGISLKKNKKASEEAAEAVATPTTAEDKPEENGQAATETKEEEPAAETNETPAPEAEAEPKVEEAEPKAEEPAQQTETAPTEETTKSEESPAPVEETTPTESSDPEPAAE
Involved in the control of cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation.
Q6PD99
C0ZIJ0
RL14_BREBN
50S ribosomal protein L14
Brevibacillus
MIQTQTRLAVADNSGAKELMCIKVLGGSGRKTANIGDVIVCSVKSATPGGVVKKGQVVKAVVVRTVSGVRRNDGSYIRFDENAAVVIKDDQSPRGTRIFGPVARELRDKDFMKIISLAPEVI
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
C0ZIJ0
Q7N8Q9
XNI_PHOLL
Flap endonuclease Xni
Photorhabdus
MIHLLIVDALNLIRRIHAVQGSPCIPACEHALRQLIQHSHPTHAVAVFDEENRNHSWRHQILPDYKAGRSPMPDNLQQEMPQIRASFEQQGVTCWHAKGHEADDLAATLAVKVTAAGHNVTIVSTDKGYCQLLSPNIRIRDYFQKRWLDMPFVQQEFGVLPEQLPDYWGLAGISSSKIPGIQGIGPKTAATLLQQAGTLDNLFQHLDQQPEKWRNKLESNQEIAFISREVASLRTDLALKGNLQQLRLTIAT
Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
Q7N8Q9
Q5CAZ6
B3GA2_CANLF
UDP-glucuronosyltransferase S
Canis
MKSALFSRFFILLPWILIVIIMLDVDTRRPAPPLTPRPYFSPYAVGRGGARLPPRRGGPDSGPGRGWEKRNESRPHARPRPEPPLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDAAARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQRNAGLAWLRQRHQHQRAQPGVLFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVENGKVVGWYTGWRADRPFAIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLKQITTVEELEPKANNCTKVLVWHTRTEKVNLANEPKY...
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on both glycolipids and glycoproteins.
Q5CAZ6
Q68WA0
RS13_RICTY
30S ribosomal protein S13
typhus group
MARIASVNIPDNKRLVVSLTYIYGLGSTMAAEICNKAKISRDKKVKVLTDQELIRLRNIIENEYKVEGDLRREVTLNIKKKKDIRCYQGLRHIRKLPVRGQNTHSNARTRKGKAIAIAGKKKTVK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
Q68WA0
Q3Z6Q4
MIAB_DEHM1
tRNA-i(6)A37 methylthiotransferase
Dehalococcoides
MPGYYLWTIGCQMNQAESERLGRLFELWGYSLADKAEDAELVLVNSCVVREHAENKVINRLHILRKLKDKNPRLKIALTGCLVGQDIASVRKKFPFVDYIFQPGALPDWGEIPEGFILPLKPPVSASITIMQGCDNFCTYCIVPYRRGREKSRSISELCCEAAELVRRGSREVVLLGQNVDSYGHDLPEKPCLADLLYALSDIPGLLRIRFLTSHPKDISQKLIDAMASLHKVCHSLSLPVQAGADTILAAMRRGYTSEQYRELVGRLKTAMPDISLQTDLIVGFPSETAEQFDQSYKLMSDIGYDAIHVAAYSPRPQTA...
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
Q3Z6Q4
Q9G4Q1
CYB_MYORT
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Myodes
MTIIRKKHPLIKIINHAFIDLPAPSNISSWWNFGSLLGLCLIIQILTGLFLAMHYTSDTSTAFSSVTHICRDVNYGWLIRYMHANGASMFFICLFLHVGRGMYYGSYNMIETWNMGIILLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVFVHLLFLHETGSNNPTGLNSDADKIPFHPYYTIKDFLGVLILLTGLMILVLFFPDVLGDPDNYTPANPLNTPAHIKPEWYFLFAYAILRSIPNKLGGVLTLILSILILALLPLLHTSKQRGLTFRPI...
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is...
Q9G4Q1
Q6CM87
ENOPH_KLULA
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
Kluyveromyces
MSQLKYILDIEGTVCPISFVKDTLYPFFLKQVESLVKTNDPTLQNLLAQFPVPQDASSLHEHIESLVNNDIKDSVLKQLQGYIWEQGYKSGEIKAPVYPDAIDFIQRHAPNVYIYSSGSVKAQILLFQHVEGDIDLTKSIAGYFDINTSGKKTEPQSYTNILKSIGVPPSSASDVVFISDNDKELDAALDVGISTILALRPGNNPVSNAEKYKALNNFSSI
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
Q6CM87
O80482
BH149_ARATH
bHLH transcription factor bHLH149
Arabidopsis
MVESLFPSIENTGESSRRKKPRISETAEAEIEARRVNEESLKRWKTNRVQQIYACKLVEALRRVRQRSSTTSNNETDKLVSGAAREIRDTADRVLAASARGTTRWSRAILASRVRAKLKKHRKAKKSTGNCKSRKGLTETNRIKLPAVERKLKILGRLVPGCRKVSVPNLLDEATDYIAALEMQVRAMEALAELLTAAAPRTTLTGT
Atypical bHLH transcription factor probably unable to bind DNA. Negatively regulates brassinosteroid signaling.
O80482
A7HVU4
MRAY_PARL1
UDP-MurNAc-pentapeptide phosphotransferase
Parvibaculum
MLYDLLGGMAGDIQALNVFRYITFRTGGATVTALLISFLFGPRIIALLKAKQRRGQPIREDGPQTHIIQKQGTPTMGGFLILVGLVPSVLLWADWSNRYVWIVLFVTLGFGAVGFADDYLKVSKISPKGVPGRVKLFFEFVIALIAMWALVLVSSEPLQTALTVPFFKTLLIELGGFFFLFGALVIVGSSNAVNLTDGLDGLAIVPVMIAAASLGLIVYLVGNAVFADYLQIHFVPGTGELAVFCGALIGAGLGFLWYNAPPAMVFMGDTGSLALGGALGAIAVAAKHELVLAIIGGLFVLEAVSVIVQVASFKLTGKRV...
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I...
A7HVU4
Q58606
MTM6_METJA
N-4 cytosine-specific methyltransferase MjaVI
Methanocaldococcus
MKVIIVKIWNKINGITLINDDFLNVDLPNESIDLIVTSPPYNVGIDYNQHDDTIPYEEYLDWTKQWLKKALTLLKKDGRLCLNIPLDKNKGGIKPVYADIVKIALDVGFKYQTTIIWNEQNISRRTAWGSFMSASAPYVIAPVETIVVLYKESWKKLSKGESDITKEEFIEWTNGLWTFPGESKKELDIQHHFR
A beta subtype methylase that recognizes the double-stranded sequence 5'-CCGG-3', methylates C-1 on both strands, and protects the DNA from cleavage by the MjaVI endonuclease.
Q58606
P0CN19
DPH1_CRYNB
S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1
Cryptococcus neoformans species complex
MPVPVDDSTAVLEPTEGIERPTKPAVKSRKRFVGSSKAATSRPVVRRVANQVPDDILHDKELNAAIAALPGNYNFEIHKTIYHIRRDNVQSVALQMPEGLMMYGCAIADIIERFTGALPMMLADVTYGACCIDDYTAKEMGAEMIVHYGHSCLIPVSQTTLKTLYVFVEIGIDTPHLSLSVRRNFPSSRSAFQRLILGAGEAAPGGKVPIALESTDESAQATPDLSTNDLPTRLALVSTIQFVAATQALRADLETAMPPLEKGEIEQEEEGMVAKVKRGDIGVWRGKYEVTVPQAKPLSPGEVLGCTAPKLNDVDALIYV...
Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3...
P0CN19
Q0MQ85
NDUAC_PONPY
NADH-ubiquinone oxidoreductase subunit B17.2
Pongo
MELVQVLKRGLQRITGHGGLRGYLRVFFRTNDAKVGTLVGEDKYGNKYYEDNKQFFGRHRWVVYTTEMNGKNTFWDVDGSMVPPEWHHWLHSITDDPPTTKPLTARKFIWTNHKFNVTGTPEQYVPYSTTRKKIQEWIPPSTPYK
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Q0MQ85
C1CT50
TRPA_STRZT
Tryptophan synthase alpha chain
Streptococcus
MPKTLTKKLNAIKAAGKGIFVPYIMAGDHEKGLDGLAETIHFLEDLGVSAIEVGIPFSDPVADGPVIEEAGLRSLAHGTSTQALVETLKTIETEIPLVIMTYFNPLFQYGVENFVKDLADTAVKGLIIPDLPHEHANFVEPFLADTDIALIPLVSLTTGIERQKELIEGAEGFVYAVAINGVTGKSGNYRADLDKHLAQLHQVADIPVLTGFGVSSQADLERFNAVSDGVIVGSKIVKALHQGEPIQDFIKQAVAYQK
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
C1CT50
P29773
ETS2_LYTVA
Protein C-ets-2
Lytechinus
SGPIQLWQFLLELLTDKTCQHIISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYSPEELHEMVGVPPRDDD
Probable transcription factor.
P29773
Q5L0U2
PYRK_GEOKA
Dihydroorotate oxidase B, electron transfer subunit
Geobacillus thermoleovorans group
MIGRERMTVASQRLIAERTYELTLSGRLVQEMRQPGQFVHVKVAASADPLLRRPLSLCHIDHKQGQCTIIYRQEGKGTALLAQKQPGDTVDVLGPLGNGFPLEAAPADSRALLVGGGIGVPPLYELAKQLTKRGVKVVSVLGFQTKAAVFYEEEFAAFGETHVATDDGSHGTAGRVTDVIEARSLEFDVLYACGPKPMLRALAERFPNRPVYLSLEERMGCGVGACFACVCHVPGSETAYKKVCSDGPVFRAGEVVL
Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
Q5L0U2
Q1WT16
MUTL_LIGS1
DNA mismatch repair protein MutL
Ligilactobacillus
MAKIHELSEILANQIAAGEVVERPASVVKELVENSIDAGAKQIDIIIEDAGLKSIQIIDDGNGIEAEDVETAFKRHATSKIIDRKDLFKVHTLGFRGEALPSIASVSDVVMETAVSGRAGTKIHIKGGEVLEKTLSASREGTTITVSDLFYNTPARLKYLKSVQTELSYISDIVNRLALSHTDVALSLTNNGRQLLQSAGNGNLQQTIGAIYGVQNARQMIKFEDANLDFKISGYTSLPKLTRASRNYISLLVNGRYVKNFQLTKAVIEGYGSKLMTGRYPITVLSIELDPTLVDVNVHPTKQEIKISKEDELVTFIQKT...
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part ...
Q1WT16
Q88BY5
NPD_PSEPK
Regulatory protein SIR2 homolog
Pseudomonas
MSNLRRAAEALRRSKTVVFFTGAGISADSGIPTFRDKLTGLWAKHDPQRLETADAFRANPTLVWSWYLWRRHQVSQAKPNSAHLSIPQLADAGWDVSVVTQNIDDLHERAGSSPVVHLHGSLMDVKCFGCHRPAELSPDQLAVPLEGQLIEPPRCTRCNGRLRPGVVWFRENLPDNAWRSAVRLVRACDLLVSVGTSGVVMPAAGIPDMALAVGATVIHVNLEDVGMDGADEIMLEGPAGVVLPALLQATGVAALSPPGVPT
NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form.
Q88BY5
B9DSA4
PFKA_STRU0
Phosphohexokinase
Streptococcus
MKRIAVLTSGGDAPGMNAAIRAVVRKAISEGMEVYGVNHGYAGLVAGDIFPISSKGVGDKISRGGTFLYSARYPEFANLEGQLAGIEQLKKHGIEGVVVIGGDGSYHGAMRLTEHGFPAVGIPGTIDNDIAGTDYTIGFDTAVNTAVEAIDKLRDTSSSHGRTFVVEVMGRNAGDIALWAGIASGADQIIVPEEEFNIQQVVKTIDDDFKKQGKNHHIIVLAEGVMSGDQFAQELKAAGNTSDLRVTNLGHILRGGSPTARDRVIASWMGSHAVELLKQGKGGFAVGIHNEELVESPILGSAEEGALFSLGEDGKIIVNN...
Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
B9DSA4
Q71VT6
SERC_LISMF
Phosphohydroxythreonine aminotransferase
Listeria
MERVYNFSAGPAVLPVPVLEKVQRELLSYNGSGMSVMELSHRSELFQNILDDAESLIRELMEIPENYKVLFLQGGASLQFDMVPMNLANGKKAAYVNTGSWAKKAISEAKKIQGVEVEVIASSEDRNFSYIPEIPTVSSDAAYLHVTTNNTIEGTAMFDVPDSAVPVVADMSSNILSSVYDVKKFGLIYAGAQKNIGPAGLTLVIVREDLIGQVEGLPSMLDFKVQAENDSMYNTPPTFAIYVAKLVFEWIKEQGGVAGIEALNRKKAALLYNYIDQSDFFSSPVEPSARSLTNVPFVTNSAEFDKAFVQEAEANGFKNL...
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
Q71VT6
O96008
TOM40_HUMAN
p38.5
Homo
MGNVLAASSPPAGPPPPPAPALVGLPPPPPSPPGFTLPPLGGSLGAGTSTSRSSERTPGAATASASGAAEDGACGCLPNPGTFEECHRKCKELFPIQMEGVKLTVNKGLSNHFQVNHTVALSTIGESNYHFGVTYVGTKQLSPTEAFPVLVGDMDNSGSLNAQVIHQLGPGLRSKMAIQTQQSKFVNWQVDGEYRGSDFTAAVTLGNPDVLVGSGILVAHYLQSITPCLALGGELVYHRRPGEEGTVMSLAGKYTLNNWLATVTLGQAGMHATYYHKASDQLQVGVEFEASTRMQDTSVSFGYQLDLPKANLLFKGSVDS...
Channel-forming protein essential for import of protein precursors into mitochondria . Plays a role in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) by forming a complex with BCAP31 and mediating the translocation of Complex I components from the cytosol to the mitochondria...
O96008
A0ZZ46
YCF4_GOSBA
Photosystem I assembly protein Ycf4
Gossypium
MSWRSESIWIEFIVGSRKTSNFCWAFILFFGSLGFLLVGTSSYLGRNLISLFPSQQIVFFPQGIVMSFYGIAGLFISSYLWCTIFWNVGSGYDRFDRKEGIVCIFRWGFPGKNRRIFLRFLMKDIQSIRIEVKEGIYARRVLYMEIRGQGAVPLTRTDENLTPREIEQKAAELAYFLRVPIEVF
Seems to be required for the assembly of the photosystem I complex.
A0ZZ46
Q4JB69
CEDA_SULAC
Crenarchaeal system for exchange of DNA protein A
Sulfolobus
MLNPFQLLFYSQLLASLTYFIGAAIYALPVPVYGVKKWAPRLITDSIYVVVWNSIYLGVLLFLGELLSLLGVTWDGYFSWLNNILYIEQSLYLMVKTILTASNAVPEVSALIQVVPFGALLTVITSALTFTSTLIAVSKIVYQYVAVFIATGVLFLSIPFRIGRSVGGAFIGSGIVFYVGLPYLPQFLAAFQMLPTQELNTPPQNASAIIDYYVHVVPSIITSLVIGPVIYIFILVGFSMGVASLVSGYGSRLPLIIDVF
Part of the Ced system, which is involved in DNA import.
Q4JB69
Q96DT0
LEG12_HUMAN
Galectin-related inhibitor of proliferation
Homo
MSQPSGGRAPGTRIYSWSCPTVMSPGEKLDPIPDSFILQPPVFHPVVPYVTTIFGGLHAGKMVMLQGVVPLDAHRFQVDFQCGCSLCPRPDIAFHFNPRFHTTKPHVICNTLHGGRWQREARWPHLALRRGSSFLILFLFGNEEVKVSVNGQHFLHFRYRLPLSHVDTLGIFGDILVEAVGFLNINPFVEGSREYPAGHPFLLMSPRLEVPCSHALPQGLSPGQVIIVRGLVLQEPKHFTVSLRDQAAHAPVTLRASFADRTLAWISRWGQKKLISAPFLFYPQRFFEVLLLFQEGGLKLALNGQGLGATSMNQQALEQL...
Binds lactose. May participate in the apoptosis of adipocytes.
Q96DT0
Q8ZYN0
PIMT_PYRAE
Protein-beta-aspartate methyltransferase
Pyrobaculum
MAKRLVEELERDGIVKSERVKRALLTVPREEFVLPEYRMMAYEDRPLPLFAGATISAPHMVAMMCELIEPRPGMKILEVGTGSGYHAAVCAEAIEKKGRIYTIEIVKELAVFAAQNLERLGYWGVVEVYHGDGKKGLEKHAPFDAIIVTAAADVIPPALIRQLKDGGVMVIPVEERLGQVLYKVVKRGDKIEKKAITYVMFVPLR
Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
Q8ZYN0
O42667
SSM4_SCHPO
Microtubule-associated protein ssm4
Schizosaccharomyces
MSYLSVGDEVLIRGELGIVRFAGSTDFESGIWLGVELLNGKGKNDGSVKGKRYFSCEKGKGIFVRACSSNVMKRPSVVKSRKKGSENISNFMEKTKAIKQKSRREPSKFERSLARPLCITPIDSSTPTKTATFYTSSTTENLDELNFSTEELSSFDTTLLNSDTSKLSGLDDSSFMEEEFVWQVDNVLQECEKKFTPHSKGSYLKENLKSELRKGRLDELMCENTALKEKIDKLNKELEKVEPQLTFLRSKNSIEKPRNFRREKFLKKFLAMQKEIKYLRKRKLQIRKIPNYKYSDRSLNSKTPKSQDNWTTQVTPSSLL...
Binds to nuclear microtubules with the effect of either modifying their structure or function. This then promotes meiotic nuclear division.
O42667
A0QEV5
PANB_MYCA1
Ketopantoate hydroxymethyltransferase
Mycobacterium avium complex (MAC)
MSEHNVYGAAQPAQPAQPAQPRTRIRTHHLQKMKAEGHKWAMLTAYDYSTARIFDEAGIPVLLVGDSAANVVYGYDTTVPVSIDELIPLVRGVVRGAPHALVVADLPFGSYEAGPAAALAAATRFMKEGGAHAVKLEGGERVAEQIAHLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGDAAEQTIADAIAVAEAGAFSVVMEMVPAGLATQITGKLTIPTIGIGAGPNCDGQVLVWQDMAGMSSGKSARFVKRFADIGGELRRAATQYAHEVAAGVFPADEHCF
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
A0QEV5
P0C1G2
TNR7_ECOLX
Transposons Tn1721 resolvase
Escherichia
MQGHRIGYVRVSSFDQNPERQLEQTQVSKVFTDKASGKDTQRPQLEALLSFVREGDTVVVHSMDRLARNLDDLRRLVQKLTQRGVRIEFLKEGLVFTGEDSPMANLMLSVMGAFAEFERALIRERQREGIALAKQRGAYRGRKKALSDEQAATLRQRATAGEPKAQLAREFNISRETLYQYLRTDD
Resolvase catalyzes the resolution (a site-specific recombination) of the cointegrated replicon to yield the final transposition products.
P0C1G2
A4X5Y3
SYDND_SALTO
Non-discriminating aspartyl-tRNA synthetase
Salinispora
MIRTHDAGSLRATDAGSTVTLAGWVARRRDHGGVIFVDLRDGSGVAQVVLREEDAHVLRNEYCVRVTGEVTRRPEGNENPELATGEVEVTAEELEVLSEAAPLPLPVDDQIEAGDDVRLRYRYLDLRRSGPASALRLRSAANQIARTVLHERDFLEIETPTLTRSTPEGARDFLVPVRLQPGTWYALPQSPQLFKQLLMVGGMERYYQIARCYRDEDFRADRQPEFTQLDIEMSFVTEDDVIDLGEAIVSRLWRELAGHQITRPIPRITWHEAMARYGSDKPDLRYGVELTELTDYLRGTRFRVFAGAIEAGGYVGAVVM...
Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).
A4X5Y3
O53076
CITC_LEUMC
Citrate lyase synthetase
Leuconostoc
MRRDWQNFLMACGIKNFDDSELNPLDITIAVYENEEIIGTGSIAGDVIKYVAVQETTMSGHSTLFNQLMTKLENFMAVEGRFHQFVLRNQFTKKVLNTLASKRWLSVNKEFCWKKDYQILRNTCQQFPSQTPIDKVASVVINANPFTNGHRFLIEEASRNNELVYVFVLNQEASLFHTDERIALVKAGVQDLSNVIVVNGGAYIISYLTFPAYFLKHNDSAIDYQTTIDVRLFKYKIASALGITSRYVGSEPLSHTTNLYNQKLISELNPQIEVHVIQRKLAAGDLGVISARTVREAIDKGDEAVWQKMVTETTQHFISN...
Acetylation of prosthetic group (2-(5''-phosphoribosyl)-3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase.
O53076
P55472
NOEE_SINFN
Nodulation protein NoeE
Sinorhizobium
MSRDVSPLPLICFLLGIPRSGTTLLAHLLQQHPDITAPPEPWLMLALEAFGRVDHRHPAGASLIQVAACEFLGRIDRISVSRVFADAAYSQYLAAAGKRTLIDKTPRYWMVLDYLHSLYPEAPHILLLRNPYAIAASLKSTWGVPFVSERCPPTSVSCLAELVTGTPTAAVALALADLVLGLPALAMQRGRRHTQVVRYERLVERPDEEIQRVIAGLGYDPAGIVFAGVEQTEYLRLSSFGDRRLLKKKAVDNRSVETWRTELTIEEMQTVTDLVGADLLVELGYEQSLQHARDAGIVDRGKAVTERYRRVFQTWWDLRR...
Required for the formation of sulfated nod factor. Proposed to transfer activated sulfate (PAPS) to the fucose of the nod factor.
P55472
B9MDJ5
RS6_ACIET
30S ribosomal protein S6
Diaphorobacter
MRHYEIILLIHPDQSEQVPAMLERYKGMIVAGGGQVHRVEDWGRRQLAYLINKLAKAHYLCLNIEADQAVMAELEHAFKFNDAVLRHLTVQKKKAETGASSMMKTVEREEARKASQAEFAASNER
Binds together with S18 to 16S ribosomal RNA.
B9MDJ5
D3JWK4
CUMC_CONCL
Conotoxin Cal22c
Californiconus
GRPSARYDAPYCSQEEVRECDDDCSGNPVRDACQCAYDPAGSPACDCFCVEPWRR
Probable neurotoxin with unknown target. Possibly targets ion channels.
D3JWK4
O48707
MTND1_ARATH
Acireductone dioxygenase (Ni(2+)-requiring) 1
Arabidopsis
MGEAAKDQTEEVIQAWYLDNKEEDQKLPHHKDPKEFVSLDKLAELGVLCWRLDADNYETDEELKRIRESRGYSYMDLCEVCPEKLPNYEEKVKMFFEEHLHIDEEIRYCLAGSGYFDVRDLNDIWIRVWVKKGGLIVFPAGIYHRFTVDSDNYMKAMRLFVGGPVWTAYNRPHDHLPARKAYMKKFLKVIGDRNIDASA
Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine...
O48707
A0A2I1BSV1
NVFK_ASPN1
Novofumigatonin biosynthesis cluster protein K
Aspergillus
MEKAKFKVVIVGGSITGLTLAHCLHQANIDHIVLERRHEIAPQEGASIGLWPNGGQILDQLGLYGELEKLTEPLNVMHVVYPDGFSYSNTLFRQIRERFGYPVFFMDRQKLLDVLYKTYPNKSKILVNKLVTELRQSDGAACVMTDDGSTYEGNLIVGADGVHSRLRSEIWRLADINQPGLVTAEEKQSMTVEYSCIFGISSPLPGLASGEHVNAYMNGLTVLTFHGKGGRVYWFVIQKLDRKFTYPNVPRFSLDDAERSCTALAKIRIWRDICIGHLWQAREVASMTALEENIFTTWHYQRAILLGDSIHKMTPNIGQG...
FAD-dependent monooxygenase; part of the gene cluster that mediates the biosynthesis of novofumigatonin, a heavily oxygenated meroterpenoid containing a unique orthoester moiety . The first step of the pathway is the synthesis of 3,5-dimethylorsellinic acid (DMOA) by the polyketide synthase nvfA via condensation of one...
A0A2I1BSV1
Q71VR4
RHAA_LISMF
L-rhamnose isomerase
Listeria
MGHETEISKRYQVAKERYQAIGVDTENALKTLKDIKISMHCWQGDDVKGFLNPDGELTGGIMATGNYPGAAHTPKQLRQDLEKAYSLIPGKHKLNLHAIYVDTDEKVDLNEIEPKHFTPWVEWAKEQGLGLDFNPTFFSHPMFKDNYTLASPDKEVRDFWIEHGKRSRKISEYFGKELGQTSINNFWVPDGIKDCPIDRYTPRKRLMEALDEVFAEKLDEKYTQEAVESKLFGLGAEAYTVGSHEFYMGYGITRDKLICLDAGHFHPTEVISNKLSSLALFSKGVMLHVSRPVRWDSDHVVIMDDELIEIGRELVRNDLL...
Catalyzes the interconversion of L-rhamnose and L-rhamnulose.
Q71VR4
A6LPQ4
RPOB_CLOB8
Transcriptase subunit beta
Clostridium
MVHPVQVGKRTRMSFGKVNDVTEMPNLIEVQLDSYEWFLREGLHEVFDDINPITNFTGNLVLEFVDYKLDMENIKYSVEECKERDATYAAPLKVSIRLQNNETGEIKEQEVFMGDFPLMTEQGTFVINGAERVIVSQLVRSPGVYYNYSIDKSGKKLYSSTVIPNRGAWLEYETDSNDVIYVRIDKTRKLSISILARAMGLGSDQELLDFFGEEERFRASIEKDNTKTKEEALLEIYKRLRPGEPPTVDSAISLIDTLFFDAKRYDLSRVGRYKFNKKLALNLRIANQVAATDIVNPQTGEIMVEKGQKISRLVAEEIQN...
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A6LPQ4
Q09330
MLO3_SCHPO
RNA-annealing protein mlo3
Schizosaccharomyces
MSMELDQSLDAIIASKPKGGIRKRRARSNKPKPTKNAKPAVNTASALKSVISEESKIIVSNLPTDVTEAQVKELFVKSIGPCKRVSLAYGPNGRSKGIATIIFSRPGDATRAYEQYEGRLVDGTRKMKVEIILDPSRQLNSLAARVSPASNASATASKNGAKSSKRKTTRRRRTPNRPKKSAEELDKEMDDYFGSNEKE
Has a role in the mRNA export process. Interferes with mitotic chromosome segregation when overexpressed.
Q09330
Q9D226
KRA53_MOUSE
Keratin-associated protein 5-3
Mus
MSCCGCCGGCGSSCCKPVCCCVPVCSCSSCGGCKGGCSSCGGCGSCGGCKGGCGSCGGCGSCGGCKGGCGSCGGCGSCGGCKGGCGSCGGCGSCGGCKGGCGSCGGCGSCGGCKGGCSSCGGCGSCGAASPSCVSPAAASPAVQALLLPVQLLQALLLPAQLLLVQLLLSLLLLHDCGSSCCPMSCSLPIYCQREI
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hai...
Q9D226
B1AJI2
RL11_UREP2
50S ribosomal protein L11
Ureaplasma
MAPKKKEVTRIAKLNLIGGQAKPGPALASVGINMAEFTKSFNDKTKDQNGKVIPVIITAYKDKSFDYVIKTTPVTFLLKDIAKIKSGAKDPKKQTVATISKEQALEIARYKLIDMTAYDEEAALRMIAGSAKQMGIVIEGVSAYKEKKGN
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
B1AJI2
Q2MFU6
KANK_STRKN
Kanamycin biosynthesis protein K
Streptomyces
MSSQLALRGPELSANLCKPEEDTLRVLVTGGSGNVGVGVVRALNAARHHVVVASRGYSPALLPEGVRAVRLERTEPDAYTRLVAAEKPDAVIDLTCHDAADAAVTLRACAGVDRVVVVSSVTAAGPATTTPVTEATAAPPLSEYGIDKLAVEETVRAAWADGTSQALLVRLGAVYRLGADLDGQLAEDGCWLAHAAAGAPAVLADDGAARWNLLHADDAGAALAELLANDRARGVLVHLASRHPLPWRELYERVHHALGRPFNPVSVPAEWAAEQLEDAEFLAETSRWDQVFDLGLLDRLAPSYQERGGPSRVTEVALWL...
Mediates the conversion of 2'-dehydrokanamycin A into kanamycin A.
Q2MFU6
C5BEV5
RNH_EDWI9
Ribonuclease H
Edwardsiella
MLKQVEIFTDGSCLGNPGPGGYGAILRYRQHEKALSAGYRLTTNNRMELMAAIVALETLTSACQVALFSDSQYVRQGITQWIHGWKRRDWKTADKKPVKNVDLWQRLDQAIGPHQVEWIWIKGHAGHPENERCDELARRAAGTPTQDDSGYTPG
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
C5BEV5
Q5RFK0
ETFB_PONAB
Electron transfer flavoprotein subunit beta
Pongo
MAELRALVAVKRVIDYAVKIRVKPDRTGVVTDGVKHSMNPFCEIAVEEAVRLKEKKLVKEVIAVSCGPAQCQETIRTALAMGADRGIHVEVPPAEAERLGPLQVARVLAKLAEKEKVDLVLLGKQAIDDDCNQTGQMTAGFLDWPQGTFASQVTLEGDKLKVEREIDGGLETLRLKLPAVVTADLRLNEPRYATLPNIMKAKKKKIEVIKPGDLGVDLTSKLSVISVEDPPQRTAGVKVETTEDLVAKLKEIGRI
Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase. Required for normal mitoch...
Q5RFK0
Q2PG83
PA2A_PROEL
Phosphatidylcholine 2-acylhydrolase
Protobothrops
MRTLWIMAVLLLGVEGGLWQFENMIMKVAKKSGILSYSAYGCYCGWGGRGTPKDATDRCCFVHDCCYGKVTGCNPKLGKYTYISENGDIICGGDGPCKEVCECDRAAAICFRDNLDTYDRKTYWKYPASNCQEDSEPC
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Q2PG83
Q6LIW6
RLMF_PHOPR
rRNA adenine N-6-methyltransferase
Photobacterium
MTQKKNKPTQKKKGLHPRNPHSQRYDFNALILSCPDLTPFVAENQFGDLSVDFSDPAAVKMLNKALLHHFYNVENWDIPPGYLCPPIPGRADYIHHIADLLAKSNEGVIPQGKHINGLDIGMGANCVYPIIGHRAYGWRFVGSDVDALSIKSAKFIVESNRSLAGGIKCRLQKKSDNIFTGIINANDIFDFTMCNPPFHASLEEATAGSERKVRNLSANAHKKGSNKKAELFAKSNTNKPVLNFGGQKAELWCPGGEDAFIQRMITESSDKPENCFWYSTLVSKKENLPALYKALKQVNAVDVRTIDMAQGQKVTRIVAW...
Specifically methylates the adenine in position 1618 of 23S rRNA.
Q6LIW6
Q9UBP9
GULP1_HUMAN
Protein GULP
Homo
MNRAFSRKKDKTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVRKLKFARHIKKSEGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTDKRIFTFICKDSESNKHLCYVFDSEKCAEEITLTIGQAFDLAYRKFLESGGKDVETRKQIAGLQKRIQDLETENMELKNKVQDLENQLRITQVSAPPAGSMTPKSPSTDIFDMIPFSPISHQSSMPTRNGTQPPPVPSRSTEIKRDLFGAEPFDPFNCGAADFPPDIQSKLDEMQEGFKMGLTLEGTVFCLDPLDSRC
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.
Q9UBP9
Q6P9B6
MEAK7_HUMAN
TLD domain-containing protein 1
Homo
MGNSRSRVGRSFCSQFLPEEQAEIDQLFDALSSDKNSPNVSSKSFSLKALQNHVGEALPPEMVTRLYDGMRRVDLTGKAKGPSENVSQEQFTASMSHLLKGNSEEKSLMIMKMISATEGPVKAREVQKFTEDLVGSVVHVLSHRQELRGWTGKEAPGPNPRVQVLAAQLLSDMKLQDGKRLLGPQWLDYDCDRAVIEDWVFRVPHVAIFLSVVICKGFLILCSSLDLTTLVPERQVDQGRGFESILDVLSVMYINAQLPREQRHRWCLLFSSELHGHSFSQLCGHITHRGPCVAVLEDHDKHVFGGFASCSWEVKPQFQG...
Activates an alternative mTOR signaling through RPS6KB2 activation and EIF4EBP1 repression to regulate cell proliferation and migration . Recruits MTOR at the lysosome, essential for MTOR signaling at the lysosome .
Q6P9B6
Q9Y9W5
RL11_AERPE
50S ribosomal protein L11
Aeropyrum
MVKGSQVKPSTTELLLKAVSAKAPSGDPIHQKIGDLPFEKIVEIAIEKKPDLLAKTLKAAVKTILGSARSIGVTVDGKDPKEVTRQVDEGVYDAVLAKYEEKWEEAEG
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
Q9Y9W5
F4KI56
SERCL_ARATH
Phosphoglycerate mutase-like protein 3
Arabidopsis
MGHEWIDAEREFKWSEDVKVESEVTEIVLVRHGETTWNAAGRIQGQIESDLNEVGLKQAVAIAERLGKEERPVAVYSSDLKRAKDTALMIAKTCFCPEVIEVPDLKERHVGSLQGLYWKEGAEKEPEAYSAFFSSQNDLEIPGGGESFDQLADRSMDALEQIAKKHKGERVIVVTHGGVLRAIYLRITQASSAGKLLNASVNVVHLRDQKWIIDSWSDVSHLSSVGFLQRGFDGDAKP
Phosphoglycerate mutase-like protein lacking PGM activity, but having a low metal-independent phosphoserine phosphatase activity in vitro. May be involved in serine biosynthesis.
F4KI56
A1SR17
DUT_PSYIN
dUTP pyrophosphatase
Psychromonas
MKQIELKILDPRIGKEFPLPEHATAGSAGMDLRACIDQALIIKPGETQLIPTGIAIHISDPGLAATILPRSGLGHKHGIVLGNLVGLIDSDYQGPLMVSCWNRSTESFRLEPGERLAQLVFLPVVQATFEIVDEFKSSERGEGGFGHSGKH
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
A1SR17
Q8DUF7
POTA_STRMU
Spermidine/putrescine import ATP-binding protein PotA
Streptococcus
MTKPIIAFKNVSKVFEDNGTVVLKNINFELEEGKFYTLLGASGSGKSTILNLIAGLLEASSGGIFLDGKRINDIPINKRDVHTVFQSYALFPHMTVFENVAFPLKLRKVAKKEIEKRVTEALNMVRLAGFEKRSIGKLSGGQRQRVAIARAIINQPKVVLLDEPLSALDLKLRTEMQYELRDLQQRLGITFVFVTHDQEEALAMSDWIFVMNDGEIVQSGTPVDIYDEPINHFVATFIGESNILPAVMIEDYLVEFNGKRFEAVDGGMRPNEAVEVVIRPEDLQITLPEEGKLQVKVETQLFRGVHYEIIAHDELGNEWM...
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
Q8DUF7
Q5FVM6
MTMRC_RAT
Phosphatidylinositol 3-phosphatase-associated protein
Rattus
MLGKGGVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEEVTLHLLPGEQLLCEASTVLKYVQEDSCQLGICGRLVCTDFRISFLGDEGSAVDNGAETHFKNKIIGVNDIPLHCVDQIYGVFDEKKKPLFGQLKKYPEKLVIHCKDLRVLHFCLRYTKEEEVKRIVSGIIHHTQSPKLLKRLFLFSYAAAVHGTAADPRNCTVMFDTPKDWCWELERTKGSVKYKTVSVNEGYRVCDRLPAYFVVPTPLLEDDVKRFQGRGIPIWCWSCHNGSALLKMSALPKEQDDSALQIQKSFLDGIYKTIHRPPYEMVKTEDLSS...
Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis.
Q5FVM6
Q7VNS2
AROE_HAEDU
Shikimate dehydrogenase (NADP(+))
Haemophilus
MARQYAVWGNPIAHSKSPYIHQLFAQQSNRRIEYAAKLGDKIAFEKQLVQFFTDGANGVNITSPFKARAFRLADVCSESCLLAGAANTLKRLDDGRLFADNTDGKGFCADLARLEWLIPEQRVLILGAGGVTKGVLLPLLLAKQKVTLSNRTHIKAVELAQQFAKYGDIQAVSLSEIVQHPPFDLIINATSLGLQGGYIALPNHLFEKSAVYDMEYASNMCTPFLNYVRTQGVTRYQDGLGMLVNQAAFSFQLWEGELPKVENVLKQLRAEMGYVK
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Q7VNS2
P30971
GTHB1_FUNHE
Gonadotropin beta-I chain
Fundulus
MQLVLMAAVLALAEVGCFGCHLKNVSIPMERCGQRVCIHTTICEGLCFSEDAVFESPDEAPEHRVCNGDWSYEVKHIQGCPESITYPVATNCYCSACNTKDTYCTRLYAHIPSC
Involved in gametogenesis and steroidogenesis.
P30971
Q9YEK9
AROA_AERPE
5-enolpyruvylshikimate-3-phosphate synthase
Aeropyrum
MVWLRAPDRVVVHPSTVEGRVEAPPSKSYTHRMLFLALLARGRSVVRRPLVSNDTLATLNAVALLGGKPRLGRGVAEVEGGEVRGGAVVYAAGSGTTIRIAMGVAAHSAEATLLYGDESLNRRPVHPLSEALRSMGARVCDTGGNPPVKVSGPLRRASVEVDAAISSQFATSLLIAGSRLGEFELSAARLSSRGYVDITLESLSMFGVRVEREGYRLFRLRGTPKPVDAAVPGDYSSASFMLAAGAIAGRVEVEGLRPVDPQPDRRIVELLRSMGARVRVEGGVVAVESTGPLEPVDVDLDGSPDLAPVAAVLAAYARGV...
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Q9YEK9
A7MIC1
RAPA_CROS8
ATP-dependent helicase HepA
Cronobacter
MPFTLGQRWISDTESELGLGTVVAIDARMVTLLFPATGENRLYARNDSPVTRVMFNPGDTVTSHEGWQLKVDEVKEENGLLIYIGTRLDTLEENVALREVFLDSKLVFSKPQDRLFAGQIDRMDRFALRYRARKYQSEQYRMPWSGLRGQRTNLIPHQLNIANDVGRRHAPRVLLADEVGLGKTIEAGMIIHQQLLAGAAERVLIVVPETLQHQWLVEMLRRFNLRFSLFDDERYAEAQHESDNPFDTEQLVICSLDFVRRNKQRLEHLCDAEWDLLVVDEAHHLVWSEDAPSREYQAIEQLAERVPGVLLLTATPEQLG...
Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on line...
A7MIC1
Q1PDH6
LAC16_ARATH
Urishiol oxidase 16
Arabidopsis
MEIPRRFCICVLTFFVFVLLSPTTVHSIIRHYKFNVMTNTTKLCSSKPIVTVNGQFPGPTIVAREGDTILIKVVNHVKYNVSIHWHGIRQLRTGWADGPAYITQCPIQPGQNYLHNFTLTGQRGTLWWHAHILWLRATVHGAIVILPKLGVPYPFPKPYKEKTIVLSEWWKSDVEELINEASRIGTAPSASDAHTINGHSGSISNCPSQSSYGLPVRAGKTYMLRIINAALNEELFFKIAGHVLTVVEVDAVYTKPYKTDTVFIAPGQTTNVLLTANANAGSNYMVAATTFTDAHIPYDNVTATATLHYIGHTSTVSTSK...
Lignin degradation and detoxification of lignin-derived products.
Q1PDH6
Q89DB4
HIS1_BRADU
ATP phosphoribosyltransferase
Bradyrhizobium
MSAPFVLAVPSKGRLQENTEAFFARAGLKLSKAGGARDYRGTIAGLDNVEVAYLSASEIAAQLSRGLAHLGVTGEDLVRENIADADKRVSLIEGLGFGYADVVVAVPQAWIDVRTMADLDDVTTGFREQHHMRMRVATKFVNLTRAFFQNHGITDYRIVESAGATEGAPAAGSAELIVDITTTGATLAANGLRVLDDGMILRSQANLVASRDADWSPQARETARVILDHIAARARANKYREVRTRFRQCDAALLGEAHSRFGVEAPFGGPTSSGMLTLHCPPGQLYALASFLREHGAETVSVVSLDYVFDRENPLFAKLE...
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Q89DB4