accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q3BQ83
SUCC_XANC5
Succinyl-CoA synthetase subunit beta
Xanthomonas
MNFHEYQSKQLLAEYGIPVPAGKVAATPDEAVEVANSLGNGPWMVKAQIHAGGRGKAGGVKFCKTTDDVKAAAAKMLGTKMSTYQTAGVELPINLVLVTTAGEIVKELYLSILVDRGTKTITYIASSEGGVEIEQVAAETPELIHALNVDFVEGVQGYHGRDFGFKLGLNAKQAGQFASIMVNLYRLFNEKDLALVEINPLAILDDGNLYALDGKFDSDDNAAFRQKQLVAMRDKTQEDETEVTASELDINYVTMDGNIGCMVNGAGLAMATMDVIKLNGGEPANFLDVGGGANKQRVIEAFKLILSSDKVEGIFVNIFG...
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinat...
Q3BQ83
B8EDW0
RSMG_SHEB2
16S rRNA 7-methylguanosine methyltransferase
Shewanella
MLSAQLEAYLAEINLPATAEQKKQLIDFVGMLNKWNKAYNLTSVRDPEAMLIRHIMDSLVVSKHLQGERFIDVGTGPGLPGIPLAIMNPDKQFVLLDSLGKRIRFQKQVSFELGIHNISSVESRVEAYQPEQKFDGVLSRAFASIQDMLTWCHHLPAEHGQFYALKGQLNDEEMQHIPSGFAVKEVIELKVPKLDEQRHLLKIIKE
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
B8EDW0
P57201
HISX_BUCAI
Histidinol dehydrogenase
Buchnera
MKYFKNIIFWNKLHPDEQKKILSRPILKENNFIKKTVKEIIENVRLFGNSALKKYTFLFDKQDINTFQVSKEKISSSSFYLSKVLKDSISVAQKNITCFHKAQIPSKIDVETEVGVRCEQIYLPLNSIGIYIPGGTAPLFSTVLMLAIPAKISGCKKIILCSPPPISNEVLYAAHICGIHDIYQVGGAQAIAALALGTETVPKVDKIFGPGNAYVTEAKLQVSSIFNGTEIDMLAGPSELLIIADNTANPDFIAADLLSQAEHGVSSQVILLTPCFELAEKVVLSINKQLNNLSRLSEILKTLKNSSVIIVKNLSECIEI...
Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.
P57201
Q55C21
MAP2_DICDI
Peptidase M
Dictyostelium
MSEIQPKTEVPPKTVEEEEESDDEEDNTKVTEGGNPTGGEGAAKKKKKKNKKKKKAAPVASAADIIDSKPIPSGLVQTNPPTIPVSKQFSNGVYPMGEIQEYRDSNSYRTTSEEKRLEERIHANIYNDVRRAAEVHRQVRKYVQGIVKPGLGLTELVESLENASRTLIEADGLKAGIAFPTGVSLNHIAAHFTPNTGDKTVLKKDDVLKIDFGTHVNGYIIDCAFTVTFDEKYDKLKDAVREATNTGIYHAGIDARLGEIGAAIQEVMESHEIELNGKTYPIRSIRNLNGHSIRPYVIHGGKTVPIVRGGEMTKMEEGEF...
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).
Q55C21
O76483
GSTT7_ANOGA
Gst1-beta
Anopheles
MTPVLYYLPPSPPCRSVLLLAKMIGVELELKALNVMEGEQLKPDFVELNPQHCIPTLDDHGLVLWESRVILAYLVSAYGKDENLYPKDFRSRAIVDQRLHFDLGTLYQRVVDYYFPTIQLGAHLDQTKKAKLAEALGWFEAMLKQYQWSAANHFTIADIALCVTVSQIEAFQFDLHPYPRVRAWLQKCKDELQGHGYKEINETGAETLAGLFRSKLKQ
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.
O76483
P25389
KCC4_YEAST
Probable serine/threonine-protein kinase KCC4
Saccharomyces
MTVANTETHSAAKPSSTIGPWKLGETLGFGSTGKVQLAQHERTGHRTAVKVISKSIFNNNGNHSNDDSVLPYNIEREIVIMKLLSHPNVLSLYDVWETNNNLYLILEYAEKGELFNLLVDHGPLPEREAINCFRQIIIGISYCHALGIVHRDLKPENLLLDSFYNIKIADFGMAALQTDADLLETSCGSPHYAAPEIVSGLPYEGFASDVWSCGVILFALLTGRLPFDEENGNVRDLLLKVQKGQFEMPNDTEISRDAQDLIGKILVVDPRQRIKIRDILSHPLLKKYQTIKDSKSIKDLPRENTYLYPLADSNNHTSAS...
Involved in regulation of bud growth during cell cycle and in septin organization. Plays a role in cell wall synthesis.
P25389
Q3AZA0
RLMN_SYNS9
tRNA m2A37 methyltransferase
unclassified Synechococcus
MKNVLLGRSAAELEDWAVAQGHKSFRGRQIHDWLYNKGVKSLSEISALPKQWRTELEAQTFRVGRLKLVHQSVAADATTKLLLATDDGETIETVGIPTDQRLTVCISSQVGCPMACRFCATGKSGLQRSLATHEIVDQVLSVREAMDRRPSHVVFMGMGEPLLNSEAVLETIRCLNTDLGIGQRRITVSTVGVPKTLPQLAELAMEKLGRAQFTLAVSLHAPNQQLREELIPTAHAYPYDDLLDDCRHYLDLTGRRVSFEYILLGELNDHPEHAAELADRVGGFQSHVNLIAYNPIEEEEFKRPTSQRIEAFRRVLERRG...
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs.
Q3AZA0
P69631
RR4_BOTIS
30S ribosomal protein S4, chloroplastic
Bothriochloa
MSRYRGPRLKKIRRLGALPGLTRKTPKSGSNQKKKFHSGKKEQYRIRLQEKQKLRFHYGLTERQLLRYVHIAGKAKRSTGQVLLQLLEMRLDNILFRLGMASTIPGARQLVNHRHILVNGRIVDIPSFRCKPRDIITTKDNQRSKRLVQNYIASSDPGKLPKHLTVDTLQYKGLVKKILDRKWVGLKINELLVVEY
With S5 and S12 plays an important role in translational accuracy.
P69631
A9BWI7
EX7L_DELAS
Exodeoxyribonuclease VII large subunit
Delftia
MSGAFGAMNPAAAPLVWEVGALCRAVSDALQARFNPVAVRGEISGFSRAASGHCYFSIKDAGGQIRCAMFRRAAQLMDFSPRDGELVELRGRLGVYEQRGDLQLVVESMQRAGQGALFEQFLRLKARLEAEGLFDAARKRSLPPLPRGIGVVTSPGAAALHDVITALRRRVPHIPVVLVPALVQGVQAPASLIDALQRLYGLAREGAGSVDGSVAGAPPIDTILLVRGGGSIEDLWAFNDERLARTIVQSPVPLISGVGHETDFTIADFCADLRAPTPTAAAELVSQPREVWMGALQLMQGRLEDGVQRLLDRQQQRLDL...
Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.
A9BWI7
A7H3V3
LPXD_CAMJD
UDP-3-O-acylglucosamine N-acyltransferase
Campylobacter
MKLSEIAEFLSLEYKGEDIEISALNSLLKANFAELTYCDGEKNTKDIPHTGAAAILVSKEYENLVPKDTKVLITQSPHLSFAFLSKLFAKPLINTAKEKVQNIAKSARIMPNVYIGDNVNIGENVIIMAGAYIGDNVSIGDESIIHPNVVIYNDTKIGKKCHLLANCVIGSDGFGYAHNKNGEHYKIYHNGNVILEDFVEVGACTTIDRAVFDSTIIKAGTKVDNLVQIGHNCNIGQNCIIVAQTGISGSSELGRNVIMGGQSATSGHLKIGDFSTIAARGGVSKNLEGGRVYGGFPIMLQKDWLKLQAKIAMKFKKD
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
A7H3V3
C9RPK4
BIOW_FIBSS
Pimeloyl-CoA synthase
Fibrobacter
MDYYSLKMRASQHVGEGENSHEQHISGAERIVGRDSVEAVCAAMVRRAMNHSKGDPDFINVKIEKVHESDIQVLKSLPVTRVDVETWQEGLEKAFGLITPLMALRQAQGPCDGAKKFKEKLQDLLRETFPMRGAMLYDIATGNRLEPDKDRGVRATYMDALHSSEVDGCKNHFNEAIVLATKVANAPGMVAEFCVSDDPNYVTGYVASKELGYVRIMKMKEMGDENGGRIFLFDSRKASAEECIEYLQKKKVLVDVVGRT
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
C9RPK4
A6LP48
IF2_THEM4
Translation initiation factor IF-2
Thermosipho
MARLRVYELARQLEMDTRDLMKELKELGIEVKSHMSYIDEETVNLLLEMYSEEDELEDELIYEEYEEEVEKEIKRKSKEFVEKSEVVKKKKGVIKLEEEDLKLDKFAQKIGIPQNRIIQDFFMKGEILKPGQTLNLQLAKKIAKIYDIKISFEVEEREEKKVNPLEEVERYFEEKYSEGEGLSERPPVVTVMGHVDHGKTTLLDYIRNTRVAEREEGGITQSIGAYQVEVNGKKITFIDTPGHEIFTEMRARGAQATDIVVLIVAADDGVMPQTVEAFNHAKSANVPIIVAINKIDKPNANVEKTKQELVNKINLIPEEW...
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
A6LP48
B8GGX9
FAEHP_METPE
D-arabino-3-hexulose-6-phosphate formaldehyde lyase
Methanosphaerula
MYQIGEALVGDGAELAHIDLIIGEKSGPVGIAFANGLSQLSAGHTPLLAVIRPNLLTKPATLIIPKVTLKNQTQVTEMFGPVQAAIAKGIADCIEEGTFKEYDIEDLVILASVYLAPEAKDYNKIYRYNYGAIKLALNRALEGFPPEKTILYEKDRGAHAVMGFKVQRLWDAPYLQVAMDLVDMGKVAKVLKEVPDNDHVIIEAGTPLIKRFGLSVISEIRKLRPNAFIIADMKILDTGNLESRMAADASADAVVISGLAPASTIEKAIEETKKTGIYSIIDMLNVPNPVELIASLKIKPDIVELHRAIDCETSCHAWGD...
Catalyzes the reversible formation of ribulose-5-phosphate and formaldehyde from 3-hexulose-6-phosphate.
B8GGX9
P18312
SRX1D_SARPE
Sarcotoxin ID
Boettcherisca
GWIRDFGKRIERVGQHTRDATIQTIAVAQQAANVAATLKG
Sarcotoxins, which are potent bactericidal proteins, are produced in response to injury. They are cytotoxic to both Gram-positive and Gram-negative bacteria.
P18312
Q8Z232
GLGA_SALTI
Starch [bacterial glycogen] synthase
Salmonella
MQVLHVCSEMFPLLKTGGLADVIGALPAAQIADGVDVRVLLPGFPDIRRGIPDAHVVSRRDTFAGKISLLFGHYNGVGIYLIDAPHLYERPGSPYHDTNLYAYIDNVLRFALLGWVGCEMACGLDPFWRPDVVHAHDWHAGLAPAYLAARGRPAKSVFTVHNLAYQGMFYAKHMDDIELPWSFFNMHGLEFNGQLSFLKAGLYYADHITAVSPTYAREITEPQFAYGMEGLLRQRHLEGRLSGILNGVDEKIWNPESDLLLASRYTRDTLEEKAENKRQLQIAMGLKVNDKVPLFAVVSRLTNQKGLDLVLEALPGLLEQ...
Synthesizes alpha-1,4-glucan chains using ADP-glucose.
Q8Z232
Q8CP98
PSTS_STAES
Phosphate-binding protein PstS
Staphylococcus
MKKWQLVGTTVLGASVLLGACGGNDGGSGDGKDLKGSAKGEGSSTVAPIVEKLNEKWAKDHKDAKISSGQAGTGAGFQKFIAGETDFSDASRPIKDEEKKKLEDKGIKYHEFKIAQDGVTIAVNKDNDFVKELTKSQLKDIYSGKAKTWKDVNSSWPDKKINAVSPNSSHGTYDFFEEEVMDKQDIKAEKNADTNAIVSSVTKNKEGIGYFGYNFYEQNKDKLKEVKIKDDNGKVTEPTKKTIQNGSYALSRPLFIYAKDKSLKDNKVMSEFMKFVLEDEGKAAEDAGYVASPKKTYKSQLDDLKDFLDKHQKSDKKDDK...
Part of the ABC transporter complex PstSACB involved in phosphate import.
Q8CP98
Q9SSE8
GLYT1_ARATH
Probable glycosyltransferase At3g07620
Arabidopsis
MRDYIPKYLNAFLLAFATFAVGFAIFIAKDSNSSSHLYFSTSSSLWTSSFSPAFITVSIFLTVHRFREKRKRNGSNPGSGYWKRDGKVEAELATARVLIREAQLNYSSTTSSPLGDEDYVPHGDIYRNPYAFHRSYLLMEKMFKIYVYEEGDPPIFHYGLCKDIYSMEGLFLNFMENDVLKYRTRDPDKAHVYFLPFSVVMILHHLFDPVVRDKAVLERVIADYVQIISKKYPYWNTSDGFDHFMLSCHDWGHRATWYVKKLFFNSIRVLCNANISEYFNPEKDAPFPEINLLTGDINNLTGGLDPISRTTLAFFAGKSH...
May be involved in cell wall biosynthesis.
Q9SSE8
Q3J2X6
MIAA_CERS4
Isopentenyl-diphosphate:tRNA isopentenyltransferase
Cereibacter
MAEEPQRSPAPTSPFAFTVPSNSLSELPDIPPDRPVLIAGPTASGKSALAARLVEDGGGAVVNADALQVYDCWRLLSARPSAAEEAALPHRLYGHVGARQTYSAGHWLKEVAGVLAEGLRPVIVGGTGLYFSALTGGLAEIPHTPPEVRAAADARLAEAGLARMVAELDAETAARIDLQNPARVQRAWEVLRATGRGLARWQAETAPPLLPLSDATALVIRPDPAWLAQRIDSRFDLMMADGALDEVRAALPDWDPTLPSARAIGAPELVAHLRGEIPLDEAVAAAKLASRQYAKRQRTWFRNRMRLWHEIRLP
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
Q3J2X6
Q54C25
GPN1_DICDI
XPA-binding protein 1 homolog
Dictyostelium
MSETTATSTTTTKTTDKDNVNNNNNNENKEEKQPINIIVLGMAGSGKTTLLQRIRAHLYENKIPGYIINLDPAVSKLPYTPNIDIRDTVNYKEVMKQFNLGPNGGIVTSLNLFSTKFDKVLEIVEKRSSSLDYIILDTPGQIEVFTWSASGTIITELMASSFPTVLVYVVDTPRTVDPTTFMSNMLYACSIMYKSKLPMVVAFNKIDITNHRFAEEWMSDFDSFQDALTNDPTYMGNLTRSLSLVLEEFYSTLQSVGVSAVDGSGIDEFFEKIGLAAQDYHKYYKADLEKIKKQKSDKEQAEANKNWEKLKRDLEESKGA...
Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.
Q54C25
Q2IBF8
CTTB2_EULMM
Cortactin-binding protein 2
Eulemur
MATDGASCEPDASRAPEEAAGATAEAARKEFDVDTLSKSELRMLLSVMEGELEARDLVIEALRARRKEVFIQERYGRFNLNDPFLALQRDYEAGAGDKEKKPVCTNPLSILEAVMAHCRKMQERMSTQLAAAESRQKKLEMEKLQLQALEQEHKKLAARLEEERGKNKQVVLMLVKECKQLSGKVIEEAQKLEEVMAKLEEEKKKTNELEEELSAEKRRSTEMEAQMEKQLSEFDTEREQLRAKLNREEAHTTDLKEEIDKMKKMIEQLKRGSDSKPSLSLPRKTKDRRSVSISVGTEGPLTRSVACQTDLAVESTEHVK...
Regulates the dendritic spine distribution of CTTN/cortactin in hippocampal neurons, thus controls dendritic spinogenesis and dendritic spine maintenance.
Q2IBF8
Q01804
OTUD4_HUMAN
HIV-1-induced protein HIN-1
Homo
MEAAVGVPDGGDQGGAGPREDATPMDAYLRKLGLYRKLVAKDGSCLFRAVAEQVLHSQSRHVEVRMACIHYLRENREKFEAFIEGSFEEYLKRLENPQEWVGQVEISALSLMYRKDFIIYREPNVSPSQVTENNFPEKVLLCFSNGNHYDIVYPIKYKESSAMCQSLLYELLYEKVFKTDVSKIVMELDTLEVADEDNSEISDSEDDSCKSKTAAAAADVNGFKPLSGNEQLKNNGNSTSLPLSRKVLKSLNPAVYRNVEYEIWLKSKQAQQKRDYSIAAGLQYEVGDKCQVRLDHNGKFLNADVQGIHSENGPVLVEEL...
Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein . May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and T...
Q01804
Q8XB78
HCHA_ECO57
Maillard deglycase
Escherichia
MTVQTSKNPQVDIAEDNAFFPSEYSLSQYTSPVSDLDGVDYPKPYRGKHKILVIAADERYLPTDNGKLFSTGNHPIETLLPLYHLHAAGFEFEVATISGLMTKFEYWAMPQKDEKVMPFFEQHKSLFRNPKKLADVVASLNADSEYAAIFVPGGHGALIGLPESQDVAAALQWAIKNDRFVISLCHGPAAFLALRHGDNPLNGYSICAFPDAADKQTPEIGYMPGHLTWYFGEELKKMGMNIINDDITGRVHKDRKLLTGDSPFAANALGKLAAQEMLAAYAG
Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and la...
Q8XB78
Q32RP5
PSBM_ZYGCR
Photosystem II reaction center protein M
Zygnema
MEVNILAFIATALFVLIPTAFLIILYVKTESSSS
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, a...
Q32RP5
Q499S9
RHDF1_RAT
Rhomboid family member 1
Rattus
MSEARRDSTSSLQRKKPPWLKLDIPAVVPPAAEEPSFLQPLRRQAFLRSVSMPAETARVPSPHHEPRRLALQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVIRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRMADDTADGLSAPHTPVTPGAASLCSFSSSRSGFNRLPRRRKRESVAKMSFRAAAALVKGRSIRDGTLRRGQRRSFTPASFLEEDMVDFPDELDTSFFAREGVLHEELSTYPDEVFESPSEAALKDWEKAPDQADLTGGALDRSELERSHLMLPL...
Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own.
Q499S9
Q8TYX9
ASD_METKA
Archaetidylserine decarboxylase beta chain
Methanopyrus
MMAPGWWKFVTPPAALGAALFPWSRPLSFLCLGTAAFLAFFFRNPPREPPSDPSLAVSPADGRLLGYVMEAGEASDDELSSYLDDPITVSVFMSPLDVHVNRAPLDGRVVEAEILKGRFRPAFRKDSATENNRAVLLFDGDPPFVVRLVSGAVARRIDLYVQEGDEVNKGEPIGMIRFGSRVDLAVPRSSVEELLVRKGDSVKAGETPVIRVKR
Catalyzes the formation of archaetidylethanolamine (PtdEtn) from archaetidylserine (PtdSer).
Q8TYX9
A1QZA2
RSMH_BORT9
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Borrelia
MGNIFHIPVLLEEIINLLEASNISDGFVFVDCTLGEGGHSSAVLKKYQNINVIGIDRDDVVLNRAKESLIEFKGRVSYFNTWFDDFFSEYPLSSKINFILADLGISMFHYKMSGRGFSFFEDERLDMRLYPGAGGLSAYDIINTFDKKRLENLIYELSGERYSRRIVKSILEYRKIKKIETPRELQDIVSKAYPRIKLKINPATKTFQALRIYVNDELFRLKRSLPLWVESLSNNGVLAIVTFHSLEDKIVKEFFKGLSKDQYCILTKKPIMPRCEEKRFNSASRSAKLRVIKKLYE
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
A1QZA2
Q6MDM3
RL10_PARUW
50S ribosomal protein L10
Candidatus Protochlamydia
MREEKQLLKQEIIDKIQRYPAFVIMQYAGLTANQANDFRRQLGKIGGDVEVVRKRVLLKAAKDAGLELDVSSLNGHIGLVFLGEDPIEATKTVFKFSQEREKIIQVLGGRFDGQIYSGDDVEKLSKLPSKDEMRAQFLSTLEAPMAQTLAVVEALLASVAYCLDNKSKQGSEEPENSASEA
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Q6MDM3
Q5WYE9
HIS51_LEGPL
ImGP synthase subunit HisH 1
Legionella
MSSVSILDYGVGNLLSVARAFQYFDASVNLVSTPEEIMSADRLVLPGVGAFEDGMKGLTTLNFIEPIKQFARSGKPFLGICLGMQMMLSKSTEFGQHEGLGLIAGEVVSVPSHGVDGQLHKIPHIGWNELVSTSEGEDWCHTILKNIPLNSSVYFVHSFMAMPSNPKKRLADTLYDGQAISAVIKDENMYGCQFHPEKSGEVGLSIIQQFLQI
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR.
Q5WYE9
Q34891
CYB_LAMGL
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Lama
MTNIRKSHPLLKIVNNAFIDLPAPSNISSWWNFGSLLGICLIMQIMTGLFLAMHYTSDTTTAFSSVAHICRDVNYGWIIRYLHANGASMFFICLYIHVGRGLYYGSYAFLETWNIGIILLFTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYVGTTLVEWIWGGFSVDKATLTRFFAFHFILPFVIAALAGVHLLFLHETGSNNPTGISSDMDKIPFHPYYTIKDILGALLLILTLLLLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSILILALIPLLHTSKQRSMMFRPI...
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is...
Q34891
A7ZQ54
GRPE_ECO24
HSP-70 cofactor
Escherichia
MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKIANLEAQLAEAQTRERDGILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMVEGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTLNGRTIRAAMVTVAKAK
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-b...
A7ZQ54
Q2PMU0
PSBZ_SOYBN
Photosystem II reaction center protein Z
Glycine subgen. Soja
MTIAFQLAVFALIAISFILLISVPVVFASPEGWSNNKNVVFSGTSLWIGLVFLVGILNSLIS
Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna.
Q2PMU0
Q50028
PUR1_MYCLE
Glutamine phosphoribosylpyrophosphate amidotransferase
Mycobacterium
MCLAVGVGVRAPKHVPQIRRLGRAGRRLRCVTNCALGSCPIVTVQQPGRDFSSPREECGVFGVWAPGELVAKLTYFGLYALQHRGQEAAGIAVADGSQVLVFKDLGLVSQVFDEQTLAAMEGHVAIGHCRYSTTGDTTWENAQPVFRNIAAGSGVALGHNGNLVNTAELAARARDAGLIAKRCPAPATTDSDILGALLAHGAADSTLEQAALELLPTVRGAFCLTFMDENTLYACRDPYGVRPLSLGRLDRGWVVASETAGLDIVGASFVRDIEPGELLAIDADGVRSTRFANPTPKGCVFEYVYLARPDSTLAGRSVHG...
Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
Q50028
A0B8V8
PFDB_METTP
GimC subunit beta
Methanothrix
MSGELPPQVQNQLAQLQQLQQQAQALVAQKSQIELLKKEAEAAIKELDKSPDDVVVYKNVGELMLRSDKATLMTELKERVDLLDLRLKTVAKQEERIQSRFNQLQDQLRQSLGQMPPRGG
Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding.
A0B8V8
Q8SQ81
COX7C_PONPY
Cytochrome c oxidase polypeptide VIIc
Pongo
MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLIVRHQLLKT
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CII...
Q8SQ81
Q834E0
PYRC_ENTFA
Dihydroorotase
Enterococcus
MKTLIKNGKIIKKENQLIEAALWLENGVIHAIGESFDEADFEQVFDANGQLITPGLVDVHVHFREPGFTYKETIKTGSKAAARGGFTTVCAMPNLNPVPDTAEKLSEVYDLIQKDAVVKVLQYAPITEELRSEVLTNQKALKEAGAFAFTNDGVGVQTAGTMYLAMKEAAALNMALVAHTEDESLLFGGVMHEGEVSKKLGLPGILSATEASQIARDITLAKETGVHYHVCHVSTEESVRVIRDAKKAGIHVTAEVSPHHLILVDEDIPGDEGFWKMNPPLRGLADRQALIDGLLDGTIDCIATDHAPHGLEEKQQSFLN...
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Q834E0
Q3IS55
DPHB_NATPD
Diphthamide biosynthesis methyltransferase
Natronomonas
MLTFVGLGLYDERSITVAGREALRSADRVFAEFYTSKLAGATVEELQNHHDIDIEVRDRAGVEQEPGPILDAAEAGGAVFLTAGDTMISTTHVDLRLRADNRGIETQIIHGTTAGAAAASLSGLQNYRFGKATTLPFPYAHGGEGVPGSVLDTIADNRKRGLHTLVYLDIKVGTGPRGPDPDHEEYMTADYAAELLAEDLDTVGVAIARAGSPDPVLAADRLSALADRSFGDPLHLLIVPGDLHVVEHDALVALAGAPESALPDPV
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosy...
Q3IS55
Q72I04
RL3_THET2
50S ribosomal protein L3
Thermus
MKGILGVKVGMTRIFRDDRAVPVTVILAGPCPVVQRRTPEKDGYTAVQLGFLPQNPKRVNRPLKGHFAKAGVEPVRILREIRDFNPEGDTVTVEIFKPGERVDVTGTSKGRGFAGVMKRWNFAGGPDSHGAHKIHRHPGSIGNRKTPGRVYKGKKMAGHYGAERVTVMNLEVVDVIPEENLLLVKGAVPGPNGGLVIVRETKKAAK
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Q72I04
Q7MI80
GAL1_VIBVY
Galactose kinase
Vibrio
MSELIQNVKTSFEQVLGYAPSHIIQAPGRVNLIGEHTDYNDGFVLPCAINYQTVVAAAKREDNLVRVVSVDYGNAVDEFDITQAITFQQDKMWANYIRGVVKCLLARGYAFTGADISVSGNVPQGAGLSSSAALEVVIGQTFKVLFNLEISQAEIALNGQQAENEFVGCNCGIMDQMISAEGRENHAMLLDCRSLETESVSMPEEMAVVIINSNKKRGLVDSEYNTRRQQCEEAARIFGVKALRDVTIEQFNEKVAELDEMVAKRARHVITENDRTVEAAQALRAHDMKRMGELMAESHASMRDDFEITVKEIDTLVEIV...
Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).
Q7MI80
O44836
MMPB_CAEEL
Zinc metalloprotease 2
Caenorhabditis
MTKWSPNGNPLSTIYLILSLFTLAHTAPTTQHSRTTTQLRLEDEDGGGGVDEDSIHFVKGQMEKYGYLKGIDHSSPQEFRQALMFFQEVLEVEQTGNVDEMTVEAASKPRCTQTDVRQEQTKRTKRFTLSKRAKWAHASGQSVTLKWYISDYTSDIDRLETRKVVEKAFKLWSSQSYIKNEKKVTLTFQEASSKDEADINILWAEGNHGDEHDFDGANGKIEGNKKENVLAHTFFPGYARPLNGDIHFDDAEDWEIDVDQVGHGSNKRFFPYVLAHEIGHALGLDHSQKADALMHPYYKNVPINEIQLDIDDKCGVIWNY...
Metalloprotease involved in molting, a process during larval stages in which a new cuticle is formed and the old cuticle is shed . Plays a role in thermotolerance probably by preventing the accumulation of oxidized lipoproteins and cholesterol .
O44836
A5WCJ9
RS17_PSYWF
30S ribosomal protein S17
Psychrobacter
MSDDIQQTEVSGTGVGIVTGKVVSNKMDKSITVLIERKVRHPLYGKQIRRSTKIKAHDENNVCKEGDVVRIIETRPISKTKSWKLVDVVETAEKI
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
A5WCJ9
O17204
OSTA1_CAEEL
Solute carrier family 51 subunit alpha homolog C
Caenorhabditis
MEIVKTIIPHNRSYIEPPIPSATEWLANMSVMHVSCLTIACVFVAITFLSSFFHLFFVLKYVSNERIRNDMYALIFMFPITTFASLVGMFIPRAAIFLYAVSLVYFMFTLFIMVTLLFNIFGGRQEMSAYLLQRNIRVNFTVPPLCFFKFLPTVESTDQNLRRIEWLVFQTPIIRTLLELVSVVVSMEQEGRRESVWFVFSQLMALLSMCIAFYGCYVMVPLGREKHAPYRFDFLFRTCDIAQCIYTIQKFVFEFAAAVGLITSDRYLPAAAKALWWASFMCTWEMMLLSALCSYCLRPAKCKFFDLYPGNDMPALSARD...
Probable transporter.
O17204
Q9SGN6
NSL1_ARATH
Protein NECROTIC SPOTTED LESIONS 1
Arabidopsis
MAFNNFTRLDAHSAAEKAVSVIGLGYDLCSDVRFSACKTTPDGSRLVEIDPTRNRDLIFPGGIVVNNVSSSIKCDKGERTRLRSDILSFNQMSEKFNQDMCLSGKIPSGMFNNMFAFSKCWPKDASSVKTLAYDGWFISLYSVEIVRKQLTLRDEVKREVPSSWDSAALAGFIEKYGTHVVVGVTMGGKDVIHVKQMRKSNHEPEEIQKMLKHWGDERFCVDPVESKSPASVYSGKPKEENLLQWGLQPFGTSVSSAVVMHTKNEEIMRVCIRRGGVDLGQSHERWLSTVSQAPNVISMCFVPITSLLSGLPGTGFLSHA...
Negatively controls the salicylic acid (SA)-mediated pathway of programmed cell death in plant immunity.
Q9SGN6
Q0ID04
NDHN_SYNS3
NAD(P)H dehydrogenase I subunit N
unclassified Synechococcus
MPLLLSGRGFRRELESAGCMAVFAPLEGGAETRLLRRLRGAGYRTQLSSARGLGDPEVFLFQKHGIRPPHLGHQSVGRGAAVGEVQEVMPLLGESMLGTKPVVLWLLEGQVLSRSELSALCDLCRREPRLKVVVEMGGARSLRWQPLKELLSN
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus co...
Q0ID04
Q3K103
NADK_STRA1
ATP-dependent NAD kinase
Streptococcus
MNFTDRATRVAIIANGKYQSKRVASKLFAAFKHDPDFYLSKKDPDIVISIGGDGMLLSAFHMYEKQLDKVRFVGVHTGHLGFYTDYRDFEVDTLINNLKNDEGEQISYPILKVTITLEDGRVIRARALNESTIKRIEKTMVADVVINQVVFERFRGDGILVSTPTGSTAYNKSLGGAVLHPTIEALQLTEISSLNNRVYRTLGSSVIIPKKDAIEIVPKRVGVYTISIDNKTVHYKNVTKIEYSIDEKSINFVSTPSHTSFWERVNDAFIGEPEH
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Q3K103
A5FMY2
RS10_FLAJ1
30S ribosomal protein S10
Flavobacterium
MSQKIRIKLKSYDHMLVDKSAEKIVKTVKTTGAVVTGPIPLPTHKKLFTVLRSPHVNKKAREQFEVMSYKRLIDIYSSSSKTIDALMKLELPSGVEVEIKV
Involved in the binding of tRNA to the ribosomes.
A5FMY2
P0DPI0
BXA1_CLOBO
Botulinum neurotoxin A heavy chain
Clostridium
MPFVNKQFNYKDPVNGVDIAYIKIPNVGQMQPVKAFKIHNKIWVIPERDTFTNPEEGDLNPPPEAKQVPVSYYDSTYLSTDNEKDNYLKGVTKLFERIYSTDLGRMLLTSIVRGIPFWGGSTIDTELKVIDTNCINVIQPDGSYRSEELNLVIIGPSADIIQFECKSFGHEVLNLTRNGYGSTQYIRFSPDFTFGFEESLEVDTNPLLGAGKFATDPAVTLAHELIHAGHRLYGIAINPNRVFKVNTNAYYEMSGLEVSFEELRTFGGHDAKFIDSLQENEFRLYYYNKFKDIASTLNKAKSIVGTTASLQYMKNVFKEK...
Responsible for host epithelial cell transcytosis, host nerve cell targeting and translocation of botulinum neurotoxin A light chain (LC) into host cytosol. Composed of 3 subdomains; the translocation domain (TD), and N-terminus and C-terminus of the receptor-binding domain (RBD) . The RBD is responsible for binding to...
P0DPI0
Q3BS36
QUEA_XANC5
Queuosine biosynthesis protein QueA
Xanthomonas
MKKSDFHYELPEELIAQAPLAERAASRLLVVPPAPAAFGDRQVRDLPELLQPGDLLIFNDTRVIPARLFGQKASGGRVEILIERLLGEREARVQIGASKSPKAGSVIALDAGGQAEVLGRDGEFYLLRFQIPTPLEHWLLEAGRLPLPPYIRREPGVEDRERYQTVFAREVGAVAAPTAGLHFDEPLLARLRERGVEFGHVTLHVGAGTFQPVRVDKLDQHVMHKEWLNVGATLVEQVRRTRARGGRVIAVGTTVVRSLESAWRKTEAAPEGELQPFAGETQIFILPGYRIRSVDAMVTNFHLPESTLMMMVCAFAGRER...
Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
Q3BS36
B4TGS4
KDUI_SALHS
DKI isomerase
Salmonella
MDVRQSIHSEHAKTLDTQTLRREFLIENIFVADEYTMVYSHIDRIIVGGIMPVSHSVEIGGEVGKQLGVSRLLDRRELGVINIGGAGAIIVDGQRHDIGHRDALYIGKGAKELVFVSNEASRPAKFYYNCAPAHTAYPTKKVSPADVAPVTLGDNLTSNRRTINKYFVPDVLETCQLSMGLTELAPGNLWNTMPCHTHERRMEVYLYFNMEEDSCVFHMMGQPQETRHIVMRNEQAVISPSWSIHSGVGTKAYTFIWGMVGENQVFDDMDHVAVQDLR
Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate.
B4TGS4
Q97KS6
POTA_CLOAB
Spermidine/putrescine import ATP-binding protein PotA
Clostridium
MEKDILIELKNVSKKYGENYVIKNLNLFVRRNEFLTFLGPSGCGKTTTLNMIAGFETPDEGNIIFEDSSINIVPPHKRQINTVFQKYALFSHMNVYENVAFGLRIKKLPEKQIREEVEKMLSLVDLKGFEKRSTDSLSGGQQQRVAIARALVNKPKLLLLDEPLGALDLKLRKEMQLELKNIQQKLGITFIFVTHDQEEALTMSDTIVVLNKGTVQQIGTPEDIYNEPKNKFVANFIGVSNILNGVMLHDYKVKFDDETFDCVDTGFNENEDVDVVVRPEDIKIVSKENGKLFGKVISAVFRGVHYEIKVEVKNTTWIIH...
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
Q97KS6
P06525
ADH1_ARATH
Alcohol dehydrogenase class-P
Arabidopsis
MSTTGQIIRCKAAVAWEAGKPLVIEEVEVAPPQKHEVRIKILFTSLCHTDVYFWEAKGQTPLFPRIFGHEAGGIVESVGEGVTDLQPGDHVLPIFTGECGECRHCHSEESNMCDLLRINTERGGMIHDGESRFSINGKPIYHFLGTSTFSEYTVVHSGQVAKINPDAPLDKVCIVSCGLSTGLGATLNVAKPKKGQSVAIFGLGAVGLGAAEGARIAGASRIIGVDFNSKRFDQAKEFGVTECVNPKDHDKPIQQVIAEMTDGGVDRSVECTGSVQAMIQAFECVHDGWGVAVLVGVPSKDDAFKTHPMNFLNERTLKGT...
Alcohol dehydrogenase mostly active on ethanol (EtOH), but exhibits broad substrates selectivity for primary and secondary alcohols (e.g. butanol, propyl alcohol, pentanol, isopentanol, ethylene glycol, isopropanol, methanol and tertiary butyl alcohol) . Converts allyl alcohol to highly toxic acryl-aldehyde . Required ...
P06525
A7MM80
RL9_CROS8
50S ribosomal protein L9
Cronobacter
MQVILLDKVANLGSLGDQVNVKAGYARNFLVPQGKAVPATKKNVEFFEARRAELEAKLADVLAAAEARAEKINALGSVTIASKAGDEGKLFGSIGTRDIADAVTAAGVDVAKSEVRLPNGVLRTTGEHEVDFQVHSEVFAKLTVNVVAE
Binds to the 23S rRNA.
A7MM80
A3PDP9
PHND2_PROM0
Probable ABC transporter phosphonate/phosphite binding protein PhnD2
Prochlorococcus
MKLKSLLSVFTISIVALTSACSTKNAGPSADPDKLIVALIPDENAATVIQDNQGLKDYLTEAFDKEIELVVTTDYSSMIEAARNDRLDLAYFGPLSYVLAKAVSDIEPFAARIKGGTKTYNSCIIGNTKKGVTSFDDIKGTTFALGDPASTSSRLFPELTLAENGLTKGKDFQGVFLGSHDAVALAVQNGNAQAGGMACPILKSLKKKGVIDPSKVTTIAQSSPIPQYPWTMRSTLSPELKEKIRFTFLDLDSDKVLKPFNADGFASITDSDYDGIRKAGKLLGLDLSKFVK
Probably part of the ABC transporter complex PhnC2D2E2. Binds strongly to methylphosphonate (MPn), ethylphosphonate (EPn) and inorganic phosphite.
A3PDP9
B1MZV1
RUVA_LEUCK
Holliday junction ATP-dependent DNA helicase RuvA
Leuconostoc
MYEYINGLITNIYPAYLVIADRSGVGYKLFVANPYRFEQNVESHVYVEQIVRENEMTLYGFIDENEKYLFNKLLNVSGIGPKSALAILASDDAAGLVTAVANDDASYLTQFPGVGKKTAQQIVLDLKGKLDDLALSAGMTVETVPTTDNQALADALAALESLGYSAKDVAKLQTVLANQKDTTDGYIRSALKFLVK
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA...
B1MZV1
Q7VGD2
RL5_HELHP
50S ribosomal protein L5
Helicobacter
MFALREKYKNEIISQLKSELNMSNPMLLPKLEKIVISVGAGDYAKDSKIMQNIADTISLIAGQKAVITLAKKSVAGFKMREGMPMGVKVTLRGKMMYNFLEKLIVIALPRVKDFRGLKRNGFDGRGNYSFGLNEQLMFPEVVYDDIMVTHGMNITIVTSTHSDKEAFKLLELLGMPFAKGR
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement...
Q7VGD2
Q9Y2T5
GPR52_HUMAN
G-protein coupled receptor 52
Homo
MNESRWTEWRILNMSSGIVNVSERHSCPLGFGHYSVVDVCIFETVVIVLLTFLIIAGNLTVIFVFHCAPLLHHYTTSYFIQTMAYADLFVGVSCLVPTLSLLHYSTGVHESLTCQVFGYIISVLKSVSMACLACISVDRYLAITKPLSYNQLVTPCRLRICIILIWIYSCLIFLPSFFGWGKPGYHGDIFEWCATSWLTSAYFTGFIVCLLYAPAAFVVCFTYFHIFKICRQHTKEINDRRARFPSHEVDSSRETGHSPDRRYAMVLFRITSVFYMLWLPYIIYFLLESSRVLDNPTLSFLTTWLAISNSFCNCVIYSLS...
Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization . May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine recep...
Q9Y2T5
Q8XVL3
RPPH_RALSO
(Di)nucleoside polyphosphate hydrolase
Ralstonia
MLDREGFRPNVGIILINARNEVFWGKRIGEHSWQFPQGGIKYGETPEQAMYRELHEEVGLLPEHVRIVGRTRDWLRYEVPDKFIRREIRGHYRGQKQIWFLLRMVGRDCDIQLRATEHPEFDAWRWSQYWVPLDAVIEFKREVYQMALSELSRFVQRSHRAPLSPYGRGGPHRERDGRDNRAGGQAGRNDQNTRGQRQPPTLMVTTSTVIVETVITSRPAAQPIDSSNPDDTPSKDSL
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
Q8XVL3
Q8RAM9
TGT_CALS4
tRNA-guanine transglycosylase
Caldanaerobacter
MAAIKYQVIKKDARTKARLGILETPHGVIETPVFMPVGTQATVKAMTPDELKEMGATIILGNTYHLYLRPGHKIIEKAGGLHKFMNWDRAILTDSGGFQVFSLSSLRKITEDGVEFRSHIDGSKHFFTPEKVIEIQNSLGSDIIMSFDECAPYPADYDYVKRSMELTIKWAKRGKKAHKNTDRQALFGIVQGGTYKDLRRECAERLVDMDFPGYAIGGLSVGEPKDLMYEIIDFTTDYLPHDKPRYLMGVGTPEDLIEGVIRGVDMFDCVLPTRIARNGTVFTSRGKLIVRDAPYAEDFSPLDEECDCYTCKNYSRAYLR...
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks th...
Q8RAM9
O34335
MELE_BACSU
Melibiose/raffinose/stachyose-binding protein MelE
Bacillus
MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSERDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGEYTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPETMDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLINGTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDVAQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKE...
Part of the ABC transporter complex MelEDC-MsmX involved in melibiose, raffinose and stachyose import. Binds melibiose, raffinose and stachyose.
O34335
P54269
CAUP_DROME
Homeobox protein caupolican
Sophophora
MAAYAQFGYAGYPTANQLTTANTDSQSGHGGGSPLSGTNEASLSPSGGSTATGLTAGPLSPGAVSQSSHHAGHKGLSTSPAEDVVGGDVPVGLSSAAQDLPSRGSCCENGRPIITDPVSGQTVCSCQYDPARLAIGGYSRMALPSGGVGVGVYGGPYPSNEQNPYPSIGVDNSAFYAPLSNPYGIKDTSPSTEMSAWTSASLQSTTGYYSYDPTLAAYGYGPNYDLAARRKNATRESTATLKAWLSEHKKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWEPKNKTEDDDDGMMSDDEKEKDAGDGGK...
Controls proneural and vein forming genes. Positive transcriptional controler of ac-sc (achaete-scute). May act as an activator that interacts with the transcriptional complex assembled on the ac and sc promoters and participates in transcription initiation.
P54269
B1ZZ93
FABV_OPITP
Enoyl-[acyl-carrier-protein] reductase [NADH]
Opitutus
MIIQPRVRGFVCVTSHPVGCAAHVQEWIDYVKSKGVIAHGPKKVLVIGASTGYGLASRVTAAFGSGAATIGVFYERPSEEGRLATPGWYNSIGFTRAARAAGLYARNFNGDAFSDDIKKQVLDAIKADLGQVDLVIYSLASPRRTHPRTGTVHKSVLKPVGAPYTNKTVDTDTGIVSEITIEPATETEIADTIAVMGGEDWELWMHALRDANLLAPNAQTVAYSYIGPEVTWPVYKNGTIGLAKNDLERAAQALDALLKPTGGRAFIAVNKALVTQASSAIPVVPLYISILYKIMKARGTHERCIEQMQRLFATHMYNGQ...
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
B1ZZ93
A4XBI0
ALR_SALTO
Alanine racemase
Salinispora
MWQAEVRVDLDAIRENVSWLRSGSAAELMAVVKGDGYGHGMVPAAHAALDGGADWLGVCTLDEALTLRRAGITVPVLAWLLAPGLPLHEGVTAGIDLGVASVAQLEEMVEAGRVAGRPARLHLKIDTGLSRGGATISEWPELLDAAAKAQADGAVEVVGVWSHFVYADAPGHPTTDRQLAVFHEGLGMVEKAGLRPRYRHLANSAATLTRPDAHFDLVRPGLAVYGLSPVAGERFGLRPAMTARARVMLTKQVPAGAGVSYGHTYTTDRASNLAVIPLGYADGVPRDASNSGPVQLGGVRRTISGRVCMDQFVLDCGDDP...
Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.
A4XBI0
A8G3L1
HEM3_PROM2
Pre-uroporphyrinogen synthase
Prochlorococcus
MTNFKLKIASRRSKLAMVQTLWVKDQLERNIPNLDVSIEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGHADIAVHSLKDLPTNLPNGLKLGCITKREDPADALVVSKKNDYYKLETLPEGSIVGTSSLRRLAQLRNKYPHLVFKDIRGNVITRIEKLDAGEFDCIILAAAGLKRLGFESRIHQIIPSEISLHAVGQGALGIECKSDDKKVLEIINVLEDKPTSQRCLAERAFLRELEGGCQVPIGVNSNIDNGQLYLTGMVASLDGKKLIKDQVIGNINNPELVGIELAKRLKLQGADKILSEIFEEFRENKN
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
A8G3L1
P68659
VHTJ_ECOL6
Lambda prophage-derived head-to-tail joining protein W
Escherichia
MTRQEELAAARAALHDLMTGKRVATVQKDGRRVEFTATSVSDLKKYIAELEVQTGMTQRRRGPAGFYV
Required for the stabilization of DNA within the phage head and for attachment of tails onto the head during morphogenesis.
P68659
Q5HN85
FUMC_STAEQ
Iron-independent fumarase
Staphylococcus
MSVRIEHDTFGEIEVPEDKYWGAQTERSKRNFPVGKEHMPIQVIYGFAQLKRGAALANHELGKLSDEKKNAIVYACDRILNGELDNHFPLVIWQTGSGTQSNMNVNEVVSYVANEYLKKHGSKETIHPNDDVNKSQSSNDTFPTAMHVALFHEVETKLEPALNHLRQTFKEKEDQYQSIIKIGRTHLQDATPIKLGQEISGWRYMLEKCEQLLSESKKHILNLAIGGTAVGTGINAHPEFGHKVAKYISQNTGYAFVSSENKFHALTSHDEIVQLHGTLKALATDLMKIANDIRWLASGPRAGLAEISIPENEPGSSIMP...
Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.
Q5HN85
Q8PP25
RSMA_XANAC
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Xanthomonas
MNSSFSAPAKKSLGQHFLADRYYIDRIVQAVDPRAGQHLVEIGPGQGAITFPLLRKHGALTVIEFDRDLIAPLTEAAAPIGALRIIHRDVLSVDFTALADGTPIRLVGNLPYNISSPILFHALDHAAAVADMHFMLQKEVVDRMAAGPGSKVYGRLSVMLQAYCEVTALFVVPPGAFRPPPKVDSAVVRLVPRDPATVLINDRRRFADVVRAGFGQRRKTLRNALSAICEPAHFDAAQVRPDARAEQLEVADFIRLANVELA
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Q8PP25
Q2NGS8
AROD_METST
Type I dehydroquinase
Methanosphaera
MIFFLLEGEREIITEICGSIIESNEKDIFKTLDKAVDLDVNYIELRLDVIENITSKKATSIIEKIRNVTDIPIILTNRTKYEGGYFPSTEEDRIKILMDNASLVEYTDIELSTNENLRQEVIDNANRTIISYHNFEKTPSSEYLENVVNSALNVGDIAKIAVKPLNIEDTYVLLRLLMEYDDLIGISMDKLGSYTRILGPILGSPVTYTAITDESAPGQFDVKTTRDILKKLKNY
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
Q2NGS8
P52479
UBP10_MOUSE
Ubiquitin-specific-processing protease 10
Mus
MALHNPQYIFGDFSPDEFNQFFVTPRSSVELPPYSGTLCSIQAEDELPDGQEHQRIEFGVDEVIEPSEGLPPTPSYSISSTLNPQAPEFILGCTTSKKIPEAVEKDETYSSIDQYPASALALESNSNAEAETLENDSGAGGLGQRERKKKKKRPPGYYSYLKDGGEDSASPATLVNGHATSVGTSGEAVEDAEFMDVLPPVMPRTCDSPQNPVDFISGPVPDSPFPRTLGGDARTAGLCEGCHEADFEQPCLPADSLLRTAGTQPYVGTDTTENFAVANGKILESPGEDTAANGAELHTDEGADLDPAKPESQSPPAESA...
Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, t...
P52479
B7NLM9
RL14_ECO7I
50S ribosomal protein L14
Escherichia
MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRGKVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIFGPVTRELRSEKFMKIISLAPEVL
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
B7NLM9
Q9FHR8
DCI1_ARATH
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, peroxisomal
Arabidopsis
MTMESYKTLEIIRKNTDSSVFHLIINRPSHLNALSLDFFIEFPKALSSLDQNPDVSVIILSGAGKHFCSGIDLNSLSSISTQSSSGNDRGRSSEQLRRKIKSMQAAITAIEQCRKPVIAAIHGACIGGGVDLITACDIRYCSEDAFFSIKEVDLAIVADLGTLQRLPSIVGYANAMELALTARRFSGSEAKDLGLVSKVFGSKSELDNGVTTIAEGIGGKSPLAVTGTKAVLLRSREVSVEQGLDYVATWNSAMLISDDLNEAVSAQMMKRKPRFAKL
Converts 3,5-dienoyl-CoAs to the corresponding 2,4-dienoyl-CoAs. Involved in degradation of unsaturated fatty acids.
Q9FHR8
P46922
OPUAC_BACSU
Glycine betaine-binding protein OpuAC
Bacillus
MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDPGSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRYKLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGEKPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGYEVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGLVVPQYMKNVNSIEDLKK
Involved in a multicomponent binding-protein-dependent transport system for glycine betaine.
P46922
P0C8L2
KA134_TITST
Toxin Tst-17
Tityus
GCRQCGGGCNKHGKCINGKCKCY
Blocks the potassium channel Shaker B.
P0C8L2
Q135I3
PLSY_RHOPS
Lysophosphatidic acid synthase
Rhodopseudomonas
MIGIYIAALVLGYLFGSIPFGLILTRIAGTEDLRSIGSGNIGATNVLRTGRKGLAAATLLLDALKGTAAVLIAAGFGGAEAAMLAALGAFLGHLFPVWLKFKGGKGVAVYIGVLLGLFWPAALVFCVLWLATAYTTRYSSLSALVAAFITPIFLWWFGHPTMASLFAVLTLLLFWMHRDNIKRLQSGTESRIGEKK
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Q135I3
Q3IMX2
RL6_NATPD
50S ribosomal protein L6
Natronomonas
MRTEIEIPDEVTATMDHLEVTVEGPNGSVTRRLWYPDITVDVEDGAVVIETDDDNAKTRSTVGTFESHVTNMFHGVTEGWEYSMEVFYSHFPMQVSVEGGDIVIENFLGEKAPRKTPVRGDTSVEVDGEELTVSGPSIEDVGQTAADIEQLTRVSDKDTRVFQDGVYITETPDRGDV
This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.
Q3IMX2
B1KMX3
RL14_SHEWM
50S ribosomal protein L14
Shewanella
MIQMQSTLDVACNSGARRVQCIKVLGGSHRRYAGIGDIIKVSVKEAIPRGKAKKGDVYSAVVVRTKKGVRRPDGSVIRFDRNAAVLLNANNAPIGTRIFGPVTRELRTEQFMKIVSLAPEVL
Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.
B1KMX3
Q47J84
RL15_DECAR
50S ribosomal protein L15
Dechloromonas
MRLNTIKPGEGSKKTAKRVGRGIGSGLGKTCGRGHKGQKSRSGGFHKVGFEGGQMPLQRRLPKRGFNSLTRARNYEVRLTDLDRLPVDEIDLLALQVAGIVPGDALSAKVILSGAISRKVVLKGVGATKGAKAAIEAVGGSIAE
Binds to the 23S rRNA.
Q47J84
Q07L90
GATC_RHOP5
Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C
Rhodopseudomonas
MSVDATTVRRIAHLARIAVTDDEVPHLQGELNAMLAFVEQLSEVDVEGVEPMTSVTPMQMKKRADLVDDGEITDKVVANAPASEDHFFLVPKVVE
Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated ...
Q07L90
Q4UUJ7
MNMA_XANC8
tRNA-specific 2-thiouridylase MnmA
Xanthomonas
MSTPRTIVGVSGGVDSSVAAWKLAQDGEPIAGLFMQNWADDGSGDCRAEDDRRDAVAVCGVLGIPFHFRDFSGEYWSGVFEHFLAEYAAGRTPNPDVLCNREVKFKHFLEAAQALGAERIATGHYARVAHLGGRWRLLRGADRNKDQSYFLHQLGQSQLAATLFPIGELEKSALRRIAQDAGLPTHAKKDSTGICFIGERDFREFLGRYLPARTGEIRDPQGQRIAEHPGVFYFTLGQREGLNIGGVRGRAAAPWYVVGKDVGSNVLYVDQDRDSPLLQSRWLQSEQAHWVTGAPPARSFSCTAQTRYRQPDEPCTVTVQ...
Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
Q4UUJ7
Q03235
ATPB_PECFR
F-ATPase subunit beta
Pectinatus
MAKGKIVQVIGPVVDIEFPAEELPSILNAITIKGKSGDIDINLTVEVMQHLGDGITRCIAMSSTDGLTRGMEAVDTGSPIKVPVGEETLGRVFNVLGQTVDHNPAPVGNKEFWPIHRPAPKFDEQETSTQILETGIKVVDLIAPYSRGGKIGLFGGAGVGKTVLIMELIHNIATQHGGYSVFSGVGERTREGNDLWSEMTESGVINKTALVYGQMNEPPGARMRVALTGLTMAEYFRDVQHQDVLLFIDNIFRFIQAGSEVSALLGRMPSAVGYQPTLTTDVGALQERITSTKKGSITSVQAVYVPADDLTDPGPAATFT...
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
Q03235
Q10XB0
CPXS3_TRIEI
Chromophore lyase CpcS/CpeS 3
Trichodesmium
MDIEEFVERSIGCWRSQRSGHSLALSHFEEVRSTIDIVDLPKTDHEVKNLCDSSGVDIENAVSPFKMSWEGESDWDENEIIKGSCVLVPIPEDDNLKKGKLLRSQGYAETVSAVGEYYITEDDTFVLYTEYESAAAEEKIWFHTSNLRFRVSLIKTSDGNGVLTASFSSEIRS
Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins.
Q10XB0
O13168
TLE3B_DANRE
Protein groucho-1
Danio
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSHAAHGPPVQLPPHPSGLQPPGIPPVTGSGSGLLALGALGSQAHLPVKDEKNHHDLEHRERESSTNNSVSPSDSLRASEKHRGSSEYSLDPKKRRVEEKDNMSRYDSDGDKSDDLVVDVSNEDPATPRVSPSHSPPENGLDKARALKKDAPNSPASVASSGSTPSSKAKDHPHNDKS...
Transcriptional corepressor that binds to a number of transcription factors.
O13168
O17502
ACTM_BRALA
Actin, muscle
Branchiostoma
MCDDEEEEEATPLVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDAYVGDEAQSKRGILTLKYPVEHGIVTNWDDMEKIWHHTFYNELRIAPEENPCLLTEAPLNPKANREKMTQIMFETFNSPAMYVCIQAVLCLYASGRTTGIVLDSGDGVSHTVPIYEGYALPHAILRLDLAGRELTNYLMKIMTDRGYSFVTTAEREIVRDIKEKLGYVALDFEQEMLTAATSTSLEKSYELPDGQVITIGNERFRCAEALFQPSFLGMESAGVHETVYNSIMKCDIDVRKDLYANNVLSGGTTMFPGIGDRMQK...
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
O17502
B1KQN1
RSMF_SHEWM
rRNA (cytosine-C(5)-)-methyltransferase RsmF
Shewanella
MVQLNQDFINSIAKDMPAHLTMDDFISYSSKPLRPSIRINTLKISSDEFVTLMAAKGWTLDPIPWCSDGFWVALDNEIQLGNTIEHIQGLFYIQEASSMLPPTALFDGLDNSSEYTILDMASAPGSKTTQMASLMDNKGLLVANEYSSSRVKVLHANVQRMGVYNTALTHFDARVFGEYLYHQFDAILLDAPCSGEGTIRKDPLALRNWSLEENASIIETQKALIESAFLALKTGGSLVYSTCALSRSENQEVCEHLMSCFPQAVEFQSLSELFPDADKSCTSEGFLHVWPQIYDSEGFFIAKVRKVADVERQKPLPKAQ...
Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA.
B1KQN1
O30124
NPD2_ARCFU
SIR2-Af2
Archaeoglobus
MEDEIRKAAEILAKSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDKLFAEPNPAHYAIAELERMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMVVGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRLRSEK
NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription.
O30124
B7GKU4
DEOD_ANOFW
Purine nucleoside phosphorylase DeoD-type
Anoxybacillus
MSVHIGAKEHEIADKILLPGDPLRAKYIAETFLEGATCYNQVRGMLGFTGTYKGHRISVQGTGMGVPSISIYVTELMQSYNVQTLIRVGTCGAIQKDVKVRDVILAMTSSTDSQMNRMTFGGIDYAPTANFDLLKTAYEIGKEKGLQLKVGSVFTADMFYNENAQFEKLARYGVLAVEMETTALYTLAAKFGRKALSVLTVSDHILTGEETTAEERQTTFNEMIEVALETAIRQ
Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
B7GKU4
Q56797
COPC_XANCJ
Copper resistance protein C
Xanthomonas
MFAFRSIATTVVMVAASLASASAFAHPKLVVSSPVDNATVSAPATINLSFTEKLLPSLSGAELTMTKMPGMEMPPMKVAAKAAPSADGKSLIVTPDKPLSTGTYRLHWRVVSNDTHPVKGSISFSVK
Mediates copper resistance by sequestration of copper in the periplasm.
Q56797
P80293
SODM_PROFR
Superoxide dismutase [Mn/Fe]
Propionibacterium
AVYTLPELPYDYSALEPYISGEIMELHHDKHHKAYVDGANTALDKLAEARDKADFGAINKLEKDLAFNLAGHVNHSVFWKNMAPKGSAPERPTDELGAAIDEFFGSFDNMKAQFTAAATGIQGSGWASLVWDPLGKRINTLQFYDHQNNLPAGSIPLLQLDMWEHAFYLQYKNVKGDYVKSWWNVVNWDDVALRFSEARVA
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Catalyzes the dismutation of superoxide anion radicals into O2 and H2O2 by successive reduction and oxidation of the transition metal ion at the active site.
P80293
P60094
PRMA_VIBVY
Ribosomal protein L11 methyltransferase
Vibrio
MPWIQIKLNATNENAELIGDMLMEETGALSVTFLDAHDTPVFEPLPGETRLWGDTDVLALYDAEADTQLIMSQIKASNMLAEGFAYKIEQLEDKDWEREWMDNFHPMKFGQRLWICPSWRDIPDPTAVNVMLDPGLAFGTGTHPTTALCLEWLEGLDLSGKTVIDFGCGSGILAIAAIKLGAEKVIGIDIDPQALLASKDNAQRNGVADQLDVYLPQDQPEGLLADVVVANILAAPLRELSSIIKGLVKPNGQLAMSGVLDTQAEDVANYYRDELHIDPIVEQSEWCRISGRKQG
Methylates ribosomal protein L11.
P60094
A8YVT3
RIMM_LACH4
Ribosome maturation factor RimM
Lactobacillus
MEYFDVARILTTHGLNGEVKVNVITDFPEERFAEGMHLSLRSDTNRTLTVEKSRPFKQFWLIQFKEITDIDQAEKLRGQILVVSEEDRGELPDGVYYYKDIFDCDVIDEETGKRIGKIVDIQSPGANDIWLVREDDGKEYWIPNIADVVKKVDVAAKKVYVELMEGLRDED
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosoma...
A8YVT3
Q3K1Y2
RNC_STRA1
Ribonuclease III
Streptococcus
MKELRSKLEKDYGIVFANQELLDTAFTHTSYANEHRLLNISHNERLEFLGDAVLQLLISQYLFTKYPQKAEGDLSKLRSMIVREESLAGFSRLCGFDHYIKLGKGEEKSGGRNRDTILGDLFEAFLGALLLDKGVEVVHAFVNKVMIPHVEKGTYERVKDYKTSLQELLQSHGDVKIDYQVTNESGPAHAKEFEVTVSVNQENLSQGIGRSKKAAEQDAAKNALATLQ
Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
Q3K1Y2
A5FRE5
CLPP_DEHMB
Endopeptidase Clp
Dehalococcoides
MISPENVVPMVIESSARGERAFDIYSLLLKERIIFLGSQINDQVANLVIAQLLFLDREDPDKDISLYIHSPGGVISAGLAMYDTMQLIRPKVSTICVGVAASMATVLLCAGAKGKRYALPNATIHMHQAMGGAQGQASDIEIAAREIMRQQDILRNILVKHTGQTMEKIVHDSDRDYYLSAQQAVEYGLIDEILQKPENK
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
A5FRE5
P0DME9
NDB4W_HETPE
Peptide Hp1412
Heterometrus
MKTHFAIFLITLFLFQMFSQSDAIFKAIWSGIKRLCGKRGLSDLYDLDEMFDGEISQADIDFLKELMR
Amphipathic peptide with antimicrobial activity.
P0DME9
Q99150
SRP54_YARLI
Signal recognition particle 54 kDa protein homolog
Yarrowia
MVLEDLGKRINGAFANLSKGGDIDEALDAMLKEVCSALLESDVNIKLVSQLRQKVKNSVKATPNGASKKKVIQKALFDELVNLVGVDESAASAAKFKPQKGKSNVVMFVGLQGSGKTTSCTKLAVYYQRRGFKVGLVCADTFRAGAFDQLKQNATKAKIPFFGSYTETDPVAVAAEGVAKFKKEKFEIIIVDTSGRHRQESELFTEMVDIGAAVKPDSTIMVLDASIGQAAEPQSRAFKDASDFGSIILTKMDGHAKGGGAISAVAATNTPIIFIGTGEHIHDLEAFSPKQFISKLLGIGDLQGLMETMQSLNLDQKKTM...
Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).
Q99150
O50634
RPOA_HALH5
Transcriptase subunit alpha
Halalkalibacterium (ex Joshi et al. 2022)
MIEIEKPVIETIEISEDAKYGKFVVEPLERGYGTTLGNSLRRILLSSLPGAAVTSVQIDGVLHEFSTIEGVVEDVTTIVLNLKQLALKIYSDEDKTLEIDTQGEGVVTAGDLTHDSDVDVLNPDLHIATLTTGAHLRMRITAKRGRGYVPAEGNKSDELAIGVIPIDSIYTPVSRVNYQVENTRVGQVTNYDKLTLDVWTDGSIRPEEAVSLGAKILTEHLNIFVGLTDQAQNAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQELTQKTEEDMMKVRNLGRKSLEEVQEKLGELGLGLRKEE
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
O50634
Q6NVP7
PABP2_XENTR
Polyadenylate-binding nuclear protein 1
Silurana
MAAVSSAASLRGADYENGLRGGAGPSGGGQDPGEDDPMGRGTLDLDLELLGQGRRSRRVGGRTAPGRRSGGRGGSGGGGAGGLEELEDEELEEEEPGELTGDQTIEDPELEAIKARVREMEEEAEKLKELQNEVEKQMNMSPPPGNAGPVIMSIEEKMEADARSIYVGNVDYGATAEELEAHFHGCGSVNRVTILCDKYTGHPKGFAYIEFSDKESVRTSLALDESLFRGRQIKVVPKRTNRPGISTTDRGFPRARYRARASSYSSRSRFYSGYTPRPRGRVYRGRARVTSWYTPY
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of pol...
Q6NVP7
Q00718
MDMB_STRMY
Acyltransferase MdmB
Streptomyces
MPPRVVRLPSLTGLRWFAALAVFACHIAQQQFFADQQVGTALLHITTLGSIAVSVFFLLSGFVLAWSARDKDSVTTFWRRRFAKIYPLHLVTFLIAGVIIFSLAEPTLPGGSVWDGLVPDLLLVQSWLPEPTIIAGFNTPSWSLSCEFAFYLTFPLWYRLVRKIPVRRLWWCAAGIAAAVICVPFVTSQFPASAETAPGMPLNELWFACWLPPVRMLEFVLGIVMALILRTGVWRGPGVVSSALLLAAAYGVTQVVPPMFTIAACSIVPAALLITALANADVQGLRTGLRSAVLVRLGEWSFAFYLVHFMVIRYGHRLMG...
Catalyzes the acylation of the mycaminose sugar during midecamycin biosynthesis.
Q00718
B3QCX5
LEU1_RHOPT
Alpha-isopropylmalate synthase
Rhodopseudomonas
MTTTTQSEQDRVIIFDTTLRDGEQCPGATMTFEEKLNVARMLDDMGVDVIEAGYPFASDGDFEAVHEIAKRSKNSVICGLSRAAHKDIDRCAEAIKPAERGRIHTFLSTSPVHMKYKLQMEAAQVYEMVISSVTRARNHTDDVEWSAEDATRTEFDFLCRCIEAAIKAGATTINLPDTVGYAVPEEYRELFRKVRETVPNSDKARFSVHCHNDLGMAVANSMAGVAGGARQIECTINGIGERAGNAALEEVVMAMRVRQDKLPYWNRIETTMLTHASKTVSAATSFPVQYNKAIVGRNAFAHESGIHQDGMIKNAQTYEI...
Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).
B3QCX5
Q8UFT1
YQGF_AGRFC
Putative pre-16S rRNA nuclease
Agrobacterium tumefaciens complex
MATLTIEELAQTLQPAQAIAGLDLGTKTIGLAMSDLSRRFATPRPVIKRVKFTQDAQVLLAFAEKEKVAAFVIGLPINMDGSAGPRAQATRAFVRTMGEKTALPFIYWDERLSTVAAERALLEMDVSRAKRAERIDSAAASFILQGALDRLSALTRAAD
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Q8UFT1
Q319M2
NADK2_PROM9
ATP-dependent NAD kinase 2
Prochlorococcus
MVLKAGLIVNDGKELAVQTASSVQEKLEKSNYEVIRVSSSGGMVGFANPDQHVRPLGYTNCVPEGFDSSMEFAIVLGGDGTVLSAARQTAPAKIPILTINTGHLGFLAEAYLSNLNEAIDKIITGNWDIEERTCFIVSVMRNDQRRWESLCLNEMALHREPLTSMCHFEISIGRHAPVDISADGVILSTPTGSTAYSLSAGGPVITPDCPVVQLTPIAPHSLASRALVFNDSEPVTVFPATPERLVMVVDGNAGCYVWPEDRVLIRKSKHSVKFIRLEDHEFFQVLRNKLGWGLPHVAKPNK
Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
Q319M2
Q9CV28
MINY3_MOUSE
Protein CARP
Mus
MSEVTKELLELVWGTKSSPGLSDTIFCRWTQGFVFSESEGSALEQFEGGPCAVIAPVQAFLLKKLLFSSEKSSWRDCSEEEQKELLCHTLCDIVESAYDSSGSYCLVSWLRGRTPEEAARISGSPAQSSCQVEHSSALAVEELGFERFHALIQKRSFRTVSELKDAVLDQYSMWGNKFGVLLFLYSVLLTKGIENIKNSIEDANEPLIDPVYGHGSQSLINLLLTGHAVSNVWDGDRECSGMQLLGIHEQAAVGFLTLMEALRYCKVGSYLKSPKFPIWIVGSETHLTVFFAKDMALVAPEAPSEQARRVFQTYDPEDNG...
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.
Q9CV28
Q01566
GSPE_DICD3
Type II traffic warden ATPase
Dickeya
MSDQPVNTPELRPVLPFSFARAQQILLLQDESVTVAEVVCVPDTPALALLEARRVAGVPLAVSQVSPEEFERQLVMRYQRDSEEARRLMEDIGNDIDFYTLAEELPDSDDLLDGEDDAPIIRLINAMLTEAIKHKASDIHIETFERHLLIRFRIDGVLREILRPQRQLASLLVSRIKVMAKLDIAEKRVPQDGRMALRIGGRAIDVRVSTLPSNYGERVVLRLLDKNSVRLDLEALGMAEHNRRQLDTLIHRPHGIILVTGPTGSGKSTTLYAALSRLNSAERNIMTVEDPIEYELEGIGQTQVNPKVDMTFARGLRAIL...
ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytopla...
Q01566