accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q566V3
MRM3A_DANRE
rRNA (guanosine-2'-O)-methyltransferase
Danio
MAALMYNVSRGLVMLGERSLFQRERYQILVNSRRFLRGLRRRPVAVLYPDGERETLIKSKRATDITSQGFTQKGKARKDVTERAAYKNCSGFVSERAEESSQINKLKLAGLRFEKAPAGDNRLARVSSVARSRAFRDKEGKVLLEGRRLICDALSAGASPQMIFFSLLERLQELPLDKLQQAKLIKVKYEDIKLWSDLVTPQGLIAIFSKPDASRLTFPKDARLQSVPLFLICDNVRDAGNLGTILRCAAAAGGDRVLLSKGCVDAWEPKVLRSAMGAHFRLPVFPNLDWDDISKHLPKNVIVHVADNYSTSTKQLVSGQ...
S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1485 (Gm1485) in the mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA.
Q566V3
Q2IL16
NUOD2_ANADE
NDH-1 subunit D 2
Anaeromyxobacter
MEKLILRRVDRQNEEMILNFGPQHPSTHGVINFLVETDGEVLKRATPDVGYLHRSIEKIGELVGYPGFMPYTDRVDYVAAMFANEGYAIAVERLLKIEVPQRAQWLRAISCELCRIASHLVSVGTMVMDIGAFTPMLHGIRERETINDLLEALCGARLTYNYHRIGGVAFDLPEGWRDKVLHFLDHFDKFLAEFDRLISFNEIYVKRLANVAVIPGPMAINYGLVGPNLRGSGVDWDVRRDLPYGAYPNFKFDVPVGKGFFGTAGDSFDRYYVRCLEMAESSKIVRQALDSLPEGEITAKVPRNIKPEAGEALGRVESAR...
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t...
Q2IL16
Q7VIL0
PNP_HELHP
Polynucleotide phosphorylase
Helicobacter
MQHIKLEFENLSEQYSFNYVAQAANGGILYQNGGSVLLASVCTQENEKYDDEFLPLSVQYIEKTYANNKFPSGFIKREGKPSEFEILTSRLIDRTLRPLFPKGYTYITSIVVMVLSYDGKSDLQLNALNAAACALYVSDLPLESLQDKAVSGVRIGRKDGHFIINPTMEQLSESELNLFVSGRDDELLMIEMKSIRTAQGANELSEENFLEALECAKNYIKNATQTYHQQFAPYKKSPFAFESANDELDEQLLNIIQTHYHTPITEAIKHMAKSERHTQLKALIKQVVRECEIEDEKKVQEHIMAYKRKLVREMILQSHI...
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
Q7VIL0
A6Q6Q3
LUXS_SULNB
Autoinducer-2 production protein LuxS
unclassified Sulfurovum
MPLLDSFTVDHTRMIAPAVRVAKRMKTPCGDDITVFDLRFCKPNEERMPSKGIHTLEHLFAGFMREHLNSKKVEIIDISPMGCRTGFYMSLLGTPKPKRVAKAWAASMKDVLNVKSQKDIPELNVYQCGSYKMHSLKEAKEIAQNVLDRGIGIMNNKKLKLSKKLLKGL
Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhom...
A6Q6Q3
P38869
SVP26_YEAST
Sed5 compartment vesicle protein of 26 kDa
Saccharomyces
MLLELISYAGTVSGFLFLTLSIASGLYYISELVEEHTEPTRRFLTRAIYGIILILILLLLLDGFPFKLTLFSIACYIVYYQNLKSFPFISLTSPTFLLSCVCVVLNHYFWFKYFNDTEVPPQFKFDPNYIPRRRASFAEVASFFGICVWFIPFALFVSLSAGDYVLPTTSEQHMAKKNDDITTNNQPKFRKRAVGLARVVINSVRKYIYSLARVFGYEIEPDFDRLAV
Plays a role in retention of a subset of membrane proteins in the early Golgi compartments. Facilitates endoplasmic reticulum to Golgi transport of mannosyltransferases MNN2 and MNN5.
P38869
Q9LVT8
RGGC_ARATH
RGG repeats nuclear RNA binding protein C
Arabidopsis
MASLNPFDLLGDDAEDPSQLAVALSQKVEKAAAAVQPPKAAKFPTKPAPPSQAVRESRNAPQGGRGGTGGRGGFSRGRGNGGYNRDNRNNDAPGNENGFSGGYRRPSEDADGASRGGSVGGYRVGGGREGPRRGGVANGESGDVERPPRNYDRHSRTGHGTGMKRNGGGRGNWGTTEDDIPPTSEEPTTEVEKSPVAEKQGGEDETPEAKKELTAEEKAQKEAEEAEAREMTLEEYEKILEEKKKALQATKVEERKVDTKVFESMQQLSNKKNTDEEIFIKLGSDKEKRKDATEKAKKSLSINEFLKPADGKRYNGRGGG...
Binds RNA.
Q9LVT8
Q254F5
SSRP_CHLFF
Small protein B
Chlamydia
MSSKEIVSNRKALRNYEVLDTVDAGVVLTGTEIKSLRDHGGNLGDAYVTISKGEAWLLNASIAPYRFGNIYNHEERRKRKLLLHRYEIQKLESKVSQKGITIIPLGMFLSRGYVKIRLGCCRGKKAHDKRQTIIAREKQREVESAMKRYR
Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemb...
Q254F5
B1I241
MIAB_DESAP
tRNA-i(6)A37 methylthiotransferase
Candidatus Desulforudis
MEMERKFVHTITFGCQMNEFDSELMTGLLEGMGYEPAKSLREADLVLINTCCVRESAENRVWGLLGSLKRYKRDKPELIVAVSGCLPQQEGTAEEIIRRFPVVDLVLGTHNRHELPGLIEEVRAGRRPVLGVRQPDSAVPEGLPVRRKSGLRAWVPVIHGCNNFCTYCVVPYVRGRECSRRPDAVVDEVCGLAAAGYREVTLLGQNVNSYGRDLGEGIDFAALLARLDGVEGLWRIRFTTSHPRDFTDRLIEVVARAAKVCEHIHLPAQAGSNRVLQRMNRGYTREDYLDLVARIRAAVPDVSLTTDLMVGFPGETEEDF...
Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.
B1I241
P73201
SYS_SYNY3
Seryl-tRNA(Ser/Sec) synthetase
unclassified Synechocystis
MLDLKQIRENPTAIQNRLNQRGGGASYDLEPILAIAAEQKAKESERTVLQSRSNEIGKLIGQKIGQGADPKGEEIQTLREEGNSLKIQLADLEPQEKDLKEQLQKLLLELPNLPCETTPIGASEADNIEVKRWGDQYLKAETVGILPHWEIGEKLGIIDSERGVKVAQSRFISLMKAGAALERALINFMLERHIGVGYQEIMPPILVNSDSLLGTGQLPKFAEESFQCRGDDLWLIPTAEVPVTNLYRDEVLDLEQLPIKHCAYTPCFRREAGSYGRDTKGLIRLHQFNKVELVKLVKPEESAAEHQALVADAEAILQAL...
Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
P73201
A6L175
DXS_PHOV8
1-deoxyxylulose-5-phosphate synthase
Phocaeicola
MEQDNLYNLLQSIDTPDDLRHLSADKLPEVCKELRQKIIDELSCNPGHFGSSLGVIELTVALHYVFNTPYDRIVWDVGHQAYGHKILTGRRDAFCTNRKLNGIRPFPSPSESEYDTFTCGHASNSISAALGMAVAAKKHGENNRHVVAVIGDGSMSGGLAFEGLNNASATPNNLLIILNDNNMAIDRSVGGMKQYLLNLQMSEGYNRIRYKISQMFHRWGILNEERRKSLIRFNNSLKSMLVQQQNVFEGMNIRYFGPIDGHDVNNLARVLKEIKDMQGPKLLHIHTTKGKGFGPAEKAATIWHAPGIFDKETGERIVVD...
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
A6L175
Q8X714
BTUB_ECO57
Outer membrane cobalamin translocator
Escherichia
MIKKASLLTACSVTAFSAWAQDTSPDTLVVTANRFEQPRSTVLAPTTVVTRQDIDRWQSTSVNDVLRRLPGVDITQNGGSGQLSSIFIRGTNASHVLVLIDGVRLNLAGGSGSADLSQFPIALVQRVEYIRGPRSAVYGSDAIGGVVNIITTRDEPGTEISAGWGSNSYQNYDVSTQQQLGDKTRVTLLGDYAHTHGYDVVAYGNTGTQAQPDNDGFLSKTLYGALEHNFTDAWSGFVRGYGYDNRTNYDAYYSPGSPLVDTRKLYSQSWDAGLRYNGELIKSQLITSYSHSKDYNYDPHYGRYDSSATLDEMKQYTVQW...
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
Q8X714
Q1GR67
KATG_SPHAL
Peroxidase/catalase
Sphingopyxis
MNDQTPIGSGCPVHQPGGVRSLLGRTNKDWWPDMLATEILTPNGPSNPMGEDFDYAKAFKSLDYYALKDDLKALMTDSQPWWPADYGHYGPFFIRMAWHAAGTYRTADGRGGANSGQQRFAPLDSWPDNGNLDKARRLLWPIKQKYGNKISWADLFILAGNVAIESMGGPVFGFGGGRVDVYEPERDIYWGSEDKWVNQGVQTRIDPAKGMETIEGPLAAIQMGLIYVNPEGPQGNPHDDEGMARDMKETFKRMAMNDEETVALTAGGHTFGKAHGNGDPSLLGPAPAGSDLAAQGFGWVSSHESGGIGEHAVTSGIEGA...
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.
Q1GR67
Q5SL86
PANB_THET8
Ketopantoate hydroxymethyltransferase
Thermus
MRRTVKDFRNAKGQRLVYLTAYDYPTARLAEAAGVDAILVGDSLGMVVLGYPSTVPVTLEEMLHHTKAARRGAPETFLVADLPYLAYATLDRALLAAERLLKEGGADAVKLEGGEEVAEIVQGLVRAGVPVLGHVGLTPQTASQLGGYKLQGRRPEEAERILKGALALEEAGAYGVVLEMVPARLAKEVTERLSVHTVGIGAGPHTDAQVLVFHDVVGLYGDFKPRFVKRYLEAGRLIQEALSRYAQEVREGVFPGEEHSF
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
Q5SL86
P22673
URIC_DROPS
Urate oxidase
Sophophora
MFATPLRQPTNASGARPAVSMDGQETPFQYEITDHGYGKDAVKVLHVSRKGPVHTIQEFEVGTHLKLYSKKDYYQGNNSDIVATDSQKNTVYLLAKKYGIESPEKFALMLGQHFLNKYSHVEEAHVHVETYPWQRVCQEETKSVNNQGQGSCNNFTSIDNRSLHNHAFIFTPTALHYCDVVIRRTDPKQTVITGIKGLRVLKTTQSSFVNFVNDEFRSLPDQYDRIFSTVVDCSWEYSDTETVNFSRAWQTVKNIILRNFAGDPQVGVSSPSVQHTLYLSEKQVLDVIPQVSVISMTMPNKHYFNFDTKPFQKIVPGDNN...
Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
P22673
Q9ERA6
TFP11_MOUSE
Tuftelin-interacting protein 39
Mus
MSLSHLYRDGEGHLDDDDDDERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDEERPSFGGKRARDYSAPVNFISAGLKKGAAEEADSEDSDAEEKPVKQEDFPKDLGPKKLKTGGNFKPSQKGFSGGTKSFMDFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQSLQDFPVADSEEEAEEEFQKELSQWRKDPSGSKKKPKYSYKTVEELKAKGRVSKKLTAPQKELSQVKVIDMTGREQKVYYSYSQISHKHSVPDEGVPLLAQLPPTAGKEARMPGFALPE...
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 a...
Q9ERA6
Q85PP1
CYB_FOSFO
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Fossa
MTNIRKSHPLIKIINESFIDLPAPSNISAWWNFGSLLGVCLILQILTGLFLAMHYTSDTATAFSSVTHICRDVNYGWIIRYMHANGASMFFICLFMHVGRGMYYGSHTFSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTNLVEWIWGGFSVDKATLTRFFAFHFILPFIISALAAVHLLFLHETGSNNPSGLTSDSDKIPFHPYYTIKDILGLLLLILILMLLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVTALVLSILILAILPLLNTSKQRGMMFRPL...
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is...
Q85PP1
P86110
KKX25_OPICY
OcyKTx6
Opisthacanthus
MESSRKSYVLMLFLAFVIMNVCSVSGEPKDGEIAGFEMEEARYDACVNACLEHHPNVRECEEACKNPVPP
Voltage-independently blocks potassium currents on hKv1.1/KCNA1 (IC(50)=217 uM), and hKv1.4/KCNA4 (IC(50)=71 uM) (expressed in CHO cells).
P86110
Q6D9A1
PNP_PECAS
Polynucleotide phosphorylase
Pectobacterium
MLNPIVRKFQYGQHTVTLETGMMARQATAAVMVSMDDTAVFVTVVGAKNAKPGQSFFPLTVNYQERTYAAGRFPGGFFRREGRPSEGETLTSRLIDRPIRPLFPEGFLNEVQVIATVVSVNPQVSPDIVAMIGASAALSLSGIPFSGPIGVARVGYLNDQYVLNPTTDELKESRLDLVVAGTQGAVLMVESEAELLSEDQMLGAVVFGHEQQQIVIENINSLVAEAGKPKWEWHAPAVNVSLEQRVQALSEARLGDAYRITEKQERYAQVNVIKTDVVAALQAEDETLNAGEIQEILGNIEKNVVRGRVLAGEPRIDGRE...
Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.
Q6D9A1
Q7N078
RL13_PHOLL
50S ribosomal protein L13
Photorhabdus
MKTFTAKPETVKRDWYVVDADGKTLGRLATEVARRLRGKHKAEYTPHVDTGDYIIIVNAEKVAVTGNKRSDKIYYHHTGHIGGIKQATFEEMIARRPERVIEIAVKGMLPKGPLGRAMYRKLKVYAGSEHNHAAQQPQVLDI
This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
Q7N078
A5CVC1
RSMG_CLAM3
16S rRNA 7-methylguanosine methyltransferase
Clavibacter
MPEPIIIEPEPAVAGSLFGDRIDVAREFTAQLGQRGEELGLIGPLEPPRLWSRHVINSVLVAPLLRPGLVGDIGTGAGLPGLVLAIARPDVDFVLIEPMERRVAWLEEQVAHLALGNVSVRRARAEEVAQEFNLDQVTARAVSAFAKLIPLTVPLVKTGGELVLMKGSNAEREVEAASKAIRKYHLEDVEVITLGSGQVDEVTRVVRARVA
Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.
A5CVC1
Q2SV73
SYA_BURTA
Alanyl-tRNA synthetase
pseudomallei group
MKAAEIREKFLKFFESKGHTIVRSSSLVPGNDPTLLFTNSGMVQFKDVFLGAETRPYSRATTAQRSVRAGGKHNDLENVGYTARHHTFFEMLGNFSFGDYFKRDAIHYAWELLTTVYKLPADKLWVTVYHDDDEAYDIWAKEVGVPAERIIRIGDNKGARYASDNFWQMGDTGPCGPCSEIFYDHGPGVWGGPPGSPEEDGDRYIEIWNLVFMQFNRDAQGNMTRLPKPCVDTGMGLERIAAVLQHVHSNYEIDLFQQLIKASARETGVADLANNSLKVIADHIRACSFLIVDGVIPGNEGRGYVLRRIVRRAIRHGYKL...
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Q2SV73
Q2YWQ8
DLTA_STAAB
D-alanine-activating enzyme
Staphylococcus
MTDIINKLQAFADANPQSIAVRHTTDELTYQQLMDESSKLAHRLQGSKKPMILFGHMSPYMIVGMIGAIKAGCGYVPVDTSIPEDRIKMIINKVQPEFVFNTTDESFESLEGEVFTIEDIKTSQDPVIFDSQIKDNDTVYTIFTSGSTGEPKGVQIEYASLVQFTEWMLELNKSGNEQQWLNQAPFSFDLSVMAIYPCLASGGTLNLVDKNMINKPKLLNEMLTSIPINIWVSTPSFMEMCLLLPTLNEEQYGSLNEFFFCGEILPHRAAKALVSRFPSATIYNTYGPTEATVAVTSIQITQEILDQYPTLPVGVERPGA...
Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the ...
Q2YWQ8
Q7WDY6
MURA_BORBR
UDP-N-acetylglucosamine enolpyruvyl transferase
Bordetella
MDKLRITGGSPLRGEVTVSGAKNAALPILCASLLTAEPLVLGNVPQLNDTSTTLRLLGRMGVRAERAGDGTVTLQADQVDNLEAPYELVKTMRASILVLGPLLARFGQARVSLPGGCAIGQRPVDQHIKGLAALGAEIEIEHGFVVARATRLKGASIRTDMVTVTGTENLLMAAVLAEGQTVLENAAREPEVVDLAELLIKMGARIQGHGTDRIVVDGVARLHGARHDVIADRIEAGTFLCAVGAAGGDITLRGAAPDTMGATLDKLVEAGLTIETGPDWIRGAMHGRPRAVGARTHEYPGFATDMQAQLMALDTVADGT...
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
Q7WDY6
Q6P6J9
TXD15_MOUSE
Thioredoxin domain-containing protein 15
Mus
MQLLCWWQVLLWVLGLPAHGLEVAEDSGHPWREERPVPALQVGAVYLHEEEVAQDHRDQARAAEPMEASLGPRGDPMVVLSVVPGAAEDQRSPEAHDGTCSAQGEEDPSCGRENLFGLQGAGGFQDREEEYYAEPGVTEAEPVATEDANSTDSLKSPKVNCEERNVTGLENFTLKILNMSQDLMDFLNPNGSDCTLVLFYTPWCRFSASLAPHFNSLPRAFPTLGFLALDASQHSSLSTRFGTVAVPNILLFQGAKPMARFNHTDRTLETLKIFIFNQTGIEAKKNVVVTQADQMGPLPSTLIKTVDWLLVFSLFFLISF...
Acts as a positive regulator of ciliary hedgehog signaling . Required for cilia biogenesis .
Q6P6J9
Q04844
ACHE_HUMAN
Acetylcholine receptor subunit epsilon
Homo
MARAPLGVLLLLGLLGRGVGKNEELRLYHHLFNNYDPGSRPVREPEDTVTISLKVTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSKDDFGGIETLRVPSELVWLPEIVLENNIDGQFGVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTFAVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHHGGATDGPGETDVIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRFLIFVMVVATLIVM...
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Q04844
Q8MI69
WFDC2_PIG
Epididymal secretory protein E4
Sus
MPACRLGLLVASLLLGLLLGLPPVTGTGAEKSGVCPAVEVDMNCTQECLSDADCADNLKCCKAGCVTICQMPNEKEGSCPQVDIAFPQLGLCLDQCQVDSQCPGQLKCCRNGCGKVSCVTPVF
Broad range protease inhibitor.
Q8MI69
Q130Z3
CH602_RHOPS
Chaperonin-60 2
Rhodopseudomonas
MAAKDVKFAGDARDRMLRGVDILANAVKVTLGPKGRNVLIEKSFGAPRITKDGVTVAKEIELEDKFENMGAQMLREVASKTNDLAGDGTTTATVLAQAIVREGAKSVAAGMNPMDLRRGIEIAVAAVIKDIGKRAKPVASSAEIAQVGTISANGDAPIGKMIAQAMQKVGNEGVITVEENKSLDTEVDIVEGMKFDRGYLSPYFVTNAEKMTVELDDVYILLHEKKVSGLQSMLPVLEAVVQSGKPLLIIAEDVEGEALATLVVNRLRGGLKVSAVKAPGFGDRRKAMLEDIAILTGGQLISEELGVKLESVTLKMLGRA...
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
Q130Z3
Q8PV89
DHYS1_METMA
Probable deoxyhypusine synthase 1
Methanosarcina
MDFGASAKNLSTPVKGAKIVPNMTVDELVKEYAGCAFGAGRLAEAVDIYYEMLASGKTTKFFGLAGAMTPAGMRNIIADLIRDGYIDVLVTTGANMVHDTVEALGLHHYKGSDCANDIQLRHECIDRIYDVYLPDQHFTDLEEFLQGVYSGLPQENLSIRQVLTEIGKNLDDDSSILKTAAEMGVPVYCPALQDSVIGLQAWLYKEGNPLHVDAFADMHEFMDICYGAESAGTMLLGGGVPKNYILQSMLVTPRSFDYAIQLTMDRPETGGLSGATLDEAQSWGKVGEDAKSVTVYADSTITLPLIVSAVRTRLSKR
Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
Q8PV89
B3DS05
HIS1_BIFLD
ATP phosphoribosyltransferase
Bifidobacterium
MLRIAVPNKGMLSEPAWNMLAEAGYRLRTNPRQLVVQDPDNGIELFYLRPLDIAVYVGRGAIDVGITGQDLLKNSGTAALEHMPLGFGASTFRFAAPNESPITTLEDVQGKRVATTFDKLVHDYLVEHGIQAETIHLDGAVESSVQLGVADLIADVVSTGTTLRNAGLRVFAEPLMHSEACLIRSPRLNEQDPRLAVLTRRLQGVLTAHQYVLMDYDIPISKVAAAVAVTPGFESPTISPLHDKQWNAVRVMVPKAKVNQLMDDLYEVGARGIIVTALQASRM
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
B3DS05
A5III4
ATPG_LEGPC
F-ATPase gamma subunit
Legionella
MAGAKEIRSKISSINKTRKITRAMEMVAASKMRKTQERMRASKPYANKIYEVIKHIARAASEYRHPFMSEREIKRIGIIVVTTDRGLCGGLNSNLFRETIRTIRNWQEHGKEVDIAVIGRKGQAFFRRVGGNILGSIDHLGDTPSINDFIGVVKIMLDAYYNGTIDSLHIVYNEFINTMTQKPFVKQLLPLPKSEEDKKTLGHHWDYIYEPEAKELLDEILERYIELQVYQAVVENIACEQAAKMIAMKSATDNAGDLIKEFQLAYNKARQAAITQELAEIVGGAAAL
Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.
A5III4
Q6QQT1
S39A1_TAKRU
Zrt- and Irt-like protein 1
Takifugu
MEYLLQVKIAALVGLLFLTLIFGFIPARVKWFRDTDGTETHRTVLSLISCFAGGVFLSACFLDIIPDYLSDINTELHARQLETSFPLPEFIMAAGFFTVLILERIVLNCKEMRATHEERTTLIPERKSGHGHGHGDGPDPESSGHHVHVDFQAHSPFRSFMLFLSLSLHSIFEGLAIGLQTTDPKVVEICIAILVHKSIIVFSLAVKLVQSAIPPLWVAAYIGVFALMSPVGIAIGISVMEAQLAAGPLIQAILEGFAAGTFVYITFLEILPHELNSPGKQLLKVLFLLLGFSIMAALSFLG
Mediates zinc uptake.
Q6QQT1
Q3AMM9
NDHN_SYNSC
NAD(P)H dehydrogenase I subunit N
unclassified Synechococcus
MPLLLTGQAFRRDLEANGCLAVQAPLEGGAETRLLRRLRGAGYSTRMTSARGLGDPEVFLTQKHGIRPPHLGHQSVGRGAAVGEVQEVAPQLGDLFESDAPVALWLLEGQVLSRSELLSLCDLCKREPRLRIIVEMGGARSLKWEPMTTYLKA
NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus co...
Q3AMM9
B2UEK3
RL18_RALPJ
50S ribosomal protein L18
Ralstonia
MNKNDSRLRRARQTRLKIAELSVARLAVHRTNLHIYAQVFSEDGTKVLASASTAEAEVRKELNGNGGNTAAATLVGKRIAEKAKAAGIEAVAFDRSGFRYHGRVKALADAAREAGLKF
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
B2UEK3
Q54WA3
PEX7_DICDI
Peroxin-7
Dictyostelium
MKRFHSHFNGYSVEFSPFEEQRLACVTSQHFGIIGNGRQYILDVLDRDIGAFKTFDTRDGLYDCTWSEENECHVASSSGDGSIKIWDTQAPSGGRPIKSFEEHTKEVYSVDWNLVTKDTFITGSWDQSIKIWNPRMDRSLKTFREHRYCIYSAIWSPRNAHLFASVSGDRTLKIWDSRDNRSLNTIKAHDHEILTCDWNKYNDKEVVTGSVDKTIRIWDIRYPDRPTTILRGHTYAVRRIKCSPHSESMLASCSYDMSVIVWDRAREQDPIIARMDHHTEFVVGLDWNMFIDGQMASCSWDEQVCVWNLGRPGQFR
Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import.
Q54WA3
A9MR43
ISPH_SALAR
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Salmonella
MQILLANPRGFCAGVDRAISIVENALAIYGAPIYVRHEVVHNRYVVDSLRKRGAIFIEQISEVPDGAILIFSAHGVSQAVRNEAKSRDLTVFDATCPLVTKVHMEVARASRRGEESILIGHAGHPEVEGTMGQYSNPEGGMYLVESPEDVWTLNVKNEDKLSFMTQTTLSVDDTSDVIDALRSRFPKIVGPRKDDICYATTNRQEAVRALAEQADVVLVVGSKNSSNSNRLAELAQRMGRRAFLIDDAADIQEAWVKEAVCVGVTAGASAPDILVQNVIARLREFGGGEAVTLEGREENIVFEVPKELRVDVREVE
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
A9MR43
C4LEP6
RNFB_TOLAT
Rnf electron transport complex subunit B
Tolumonas
MNHILLIILIFAALALIFGLLLGFAAIHFKVESDPIVDQLDALLPQTQCGQCGYPGCRPYAEAIANGDSINKCVPGGAQTIQNIADLMGVEPPSDDNELLMAPPKRVAFIHENLCIGCTKCIQACPVDAIIGAPKLMHTILRSECTGCDLCVDPCPTNCIEMIELPATPDRWKWDVETIPVRMVQ
Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
C4LEP6
Q8R7S8
ISPF_CALS4
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Caldanaerobacter
MGKMRVGIGYDVHRFEEGKKLMLGGIEIPFEKGLKGHSDGDVLIHALIDGILGAAGLGDIGEHFPDTDVAYKEVDSKILLKRVLELVSEHYVVNNVDCIVVTERPKLSPYKDRIRTSLAELLGVSKERVNVKAKTEEGLGFTGREEGIKAYAVVLLEERY
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a correspond...
Q8R7S8
Q32J55
HEMH_SHIDS
Protoheme ferro-lyase
Shigella
MRQTKTGILLANLGTPDSPTPEAVKRYLKQFLSDRRVVDTSRLLWWPLLRGVILPLRSPRVAKLYASVWMEGGSPLMVYSRQQQQALAQRLPETPVALGMSYGSPSLESAVDELLAEHVDHIVVLPLYPQFSCSTVGAVWDELARILARKRSIPGISFIRDYADNHDYINALANSVRASFAKHGEPDLLLLSYHGIPQRYADEGDDYPQRCRTTTRELASALGMAPEKVMMTFQSRFGREPWLMPYTDETLKMLGEKGVGHIQVMCPGFAADCLETLEEIAEQNREVFLGAGGKKYEYIPALNATPEHIEMMANLVAAYR
Catalyzes the ferrous insertion into protoporphyrin IX.
Q32J55
Q9BKU8
MOAG4_CAEEL
Small EDRK-rich factor
Caenorhabditis
MTRGNQRDLAREKNQKKLADQKKRQGASGQDGNAGLSMDARMNRDADVMRIKQEKAAAKKEAEAAAAAANAKKVAKVDPLKM
Positive regulator of protein aggregation and age-related proteotoxicity . Induces conformational changes in aggregation-prone proteins, driving them into compact formations preceding the formation of aggregates .
Q9BKU8
Q05619
BUK_CLOB8
Butyrate kinase
Clostridium
MSYKLLIINPGSTSTKIGVYEGEKELFEETLRHTNEEIKRYDTIYDQFEFRKEVILNVLKEKNFDIKTLSAIVGRGGMLRPVEGGTYAVNDAMVEDLKVGVQGPHASNLGGIIAKSIGDELNIPSFIVDPVVTDELADVARLSGVPELPRKSKFHALNQKAVAKRYGKESGQGYENLNLVVVHMGGGVSVGAHNHGKVVDVNNALDGDGPFSPERAGSVPIGDLVKMCFSGKYSEAEVYGKAVGKGGFVGYLNTNDVKGVIDKMEEGDKECESIYKAFVYQISKAIGEMSVVLEGKVDQIIFTGGIAYSPTLVPDLKAKV...
Catalyzes the conversion of butyryl-CoA through butyryl phosphate to butyrate.
Q05619
Q09629
KADY_CAEEL
Adenylate monophosphate kinase
Caenorhabditis
MYRVLLSGAAGSGKGTIARMLVREFEPLGFNYFAAGDFIRDHIARGTEFGVRAQSFLNKGEHVPDSILNGAILAEMLKAGPRVVLDGYPRNMSQLKMVEEQAPLNLIVELKVPRKVLIDRLSKQLVHPASGRAYNLEVNPPKEEGKDDITGEPLFKRSTDQLEVARRRLEVYDKTENKVLDYYKKQNKCITMSGESSKAVFESVAEVMRRDLLTTTPRTAYA
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Q09629
Q8Z3X0
GCSP_SALTI
Glycine dehydrogenase (aminomethyl-transferring)
Salmonella
MTQTLSQLENRGAFIERHIGPDAAQQQEMLNAVGAESLNALTGQIVPKDIQLATPPQVGEAATEYAALAELKAIAGRNKRFTSYIGMGYTAVQLPPVILRNMLENPGWYTAYTPYQPEVSQGRLEALLNFQQVTLDLTGLDMASASLLDEATAAAEAMAMAKRVSKLKNANRFFVAADVHPQTLDVVRTRAKTFGFDVIVDDADKVLDHQDVFGVLLQQVGTTGEIHDYGTLISELKARKVIVSVAADFMALVLLTAPGKQGADIVFGSAQRFGVPMGYGGPHAAFFAAKDEFKRSMPGRIIGVSKDAAGNTALRMAMQT...
The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.
Q8Z3X0
A3MKJ8
CLPP_BURM7
Endopeptidase Clp
pseudomallei group
MINRAQLLDTLASQAPRDFEAQALGLVPIVVETSGRGERSYDIYSRLLKERIVFMVGEVNDQTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGMAIYDTMQFVKPDVSTLCMGLAASMGAFLLASGAKGKRYALPNARVMIHQPLGGARGQASDIEIQAREILYLRDRLNHLLAHHTGQDVERIARDTDRDNFMSSEDAKAYGLIDHVSTKRP
Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.
A3MKJ8
A1T4P6
RL16_MYCVP
50S ribosomal protein L16
Mycolicibacterium
MLIPRKVKHRKQHHPKQRGIASGGTSVSFGDYGIQALGHAYVTNRQIESARIAINRHIKRGGKVWINIFPDRPLTKKPAETRMGSGKGSPEWWVANVKPGRVLFELSYPDEKIAREALTRAIHKLPIKARIVTREEQF
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
A1T4P6
Q5KUD5
CHDC_GEOKA
Hydrogen peroxide-dependent heme synthase
Geobacillus thermoleovorans group
MSEAAQTLDGWYCLHDFRTIDWSAWKTLPNEEREAAISEFLALVDQWETTESEKQGSHAVYTIVGQKADILFMILRPTLDELHEIETALNKTKLADYLLPAYSYVSVVELSNYLASGSEDPYQIPEVRRRLYPILPKTNYICFYPMDKRRQGNDNWYMLSMEQRRELMRAHGMTGRKYAGKVTQIITGSVGLDDFEWGVTLFSDDALQFKKLVYEMRFDEVSARFGEFGSFFVGTRLSVEKVPSFFHV
Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the decarboxylation of Fe-coproporphyrin III (coproheme) to heme b (protoheme IX), the last step of the pathway. The reaction occurs in a stepwise manner with a three-propionate intermediate.
Q5KUD5
A0A0B5ADT3
INS2B_CONGE
Con-Ins G2b A chain
Gastridium
MTTSSYFLLVALGLLLYVRQSFSTHEHTCQLDDPAHPQGKCGSDLVNYHEEKCEEEEARRGGTNDGGKKRRRASPLRKRRRFISMLKARAKRRGYQGIACECCQHYCTDQEFINYCPPVTESSSSSSSAV
This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock. Intraperitoneal injection of this peptide into zebrafish lowers blood glucose with the same potency than human insulin. In vivo, when applied to water, this peptide reduces overall locomotor activity of ...
A0A0B5ADT3
B7MXU7
EUTC_ECO81
Ethanolamine ammonia-lyase small subunit
Escherichia
MDQKQIEEIVRSVMASMGQTAPAPSEAKCTTTNCAAPVTSESCALDLGSAEAKAWIGVENPHRADVLTELRRSTVARVCTGRAGPRPRTQALLRFLADHSRSKDTVLKEVPEEWVKAQGLLEVRSEISDKNLYLTRPDMGRRLCAEAVEALKAQCVANPDVQVVISDGLSTDAITVNYEEILPPLMAGLKQAGLKVGTPFFVRYGRVKIEDQIGEILGAKVVILLVGERPGLGQSESLSCYAVYSPRMATTVEADRTCISNIHQGGTPPVEAAAVIVDLAKRMLEQKASGINMTR
Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.
B7MXU7
Q57XV5
SLX1_TRYB2
Structure-specific endonuclease subunit SLX1 homolog
Trypanosoma
MDTRFHCVYLLTSLDPQCEGAHYIGYTVNPIRRLRQHNGELVNGARRTKRNGRPWLLLMCVSGFGEDRIALKFEWCWQNPSKSTRLKSHVSQLRCVHKLTHAVGVLLLLLRTELFSRLQLTLHIFDREHFDKVISQLLSALPTMEPLVETSLLRVESTTIEQFQTQYMNDGQWGAAVDYGAYFMRAPPGANVDVSKPIVGGQDNTLRCGVMHNNLCEEEVIRQHVKERTLLESGHYPCSLCSLPLRAPYFLRCSRTPFCRLRAHIVCLAMWFIYDSSQRGGDPLVKDAGPAEVAENSNDAACQVNENCYSLSGCGPVVGG...
Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
Q57XV5
Q8I8U2
AP1G_DICDI
Gamma1-adaptin
Dictyostelium
MSSKLRDLIKTVRSCKTAAEERSQIAKESALIRTAMKEEDLESRQRNVAKLLYIHMLGYPTQFGQMECLKLIVSPSYADKRIGYLGLMLLLDEKQEVLLLATNCIRGDIMNSNQFIVGVSLCAFGNICSTAMARDISPEIEKVISHSNPYIRKKAALCAIRVLRKVPDLTENYIPKIKALLSERNHAVILTALTLIIEICEMDSTQIIHFKKMVPQLVRILKSLTSSGYLPEHDIGGVTDPFLQVKILRLLRILGQNDPEASDAMNDILAQVSTNTDSTKNVGNAILYECVQTIMTIESENGLKVMAINILGRFLLNRDN...
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involve...
Q8I8U2
Q97EQ4
GMHA_CLOAB
Sedoheptulose 7-phosphate isomerase
Clostridium
MKNFIEAQIKSSIEAKEKILKDGQYIEQIQSIVEIVIQAYKLGKKVLLCGNGGSAADSQHIAAEFVSKFRLDRKALPAIALTVNTSVLTSIGNDYSYKNIFERQVEAFGKEGDVLIGISTSGNSENITLAFKKAKEIGITTIGFLGKDGGENKNYCDFPLIVPSEDTPRVQEAHIMIGHIVCDIVEKELFGEKVDE
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Q97EQ4
Q2F5R8
EIF3E_BOMMO
Eukaryotic translation initiation factor 3 subunit 6
Bombyx
MSYSKFDLTFKIGQYLDRHLVFPLLEFLAAKETYDQSELLQAKLEILSKTNMIDYVTDIRRMLYPEEDTPEEIIQRRGVVLSELQELQDAVEPVLRLMQRDDVMKTIETMRDPKTLINHLSTNKEYEFKIEMIDSMYRLAKYRYECGNYVESASYLYFCQLVMSPTDKNYLSVLWGKLASEILVQNWDGALDDLTKLREFIDNGGAGSTASNMQALQQRTWLVHWSLFVFFNHVKGRDLIIEMFLYKPLYLNAIQTMCPHILRYLATAVIINRSRRNALKDLVKVIQQEAYTYRDPITEFIEHLYVNFDFEAARRKLNQC...
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates t...
Q2F5R8
P00402
COX1_EMEND
Cytochrome c oxidase polypeptide I
Aspergillus subgen. Nidulantes
MIIDLNTNNVLGKKFSTSTKKENIKQIESSSFLTFKQPTEWQERWYLSSNAKDIGTLYLMFALFSGLLGTAFSVLIRLELSGPGVQYIADNQLYNSIITAHAIMMIFFMVMPALIGGFGNFLLPLLVGGPDMAFPRLNNISFWLLVPSLLLFVFSATIENGAGTGWTLYPPLSGIQSHSGPSVDLAIFGLHLSGISSMLGAMNFITTILNMRSPGIRLHKLALFGWAVIITAVLLLLSLPVLAGGITMVLTDRNFNTSFFEVAGGGDPILFQHLFWFFGHPEVYILIIPGFGIISTVIAAGSGKNVFGYLGMVYAMMSIG...
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CII...
P00402
Q086I8
DAPB_SHEFN
4-hydroxy-tetrahydrodipicolinate reductase
Shewanella
MTAKVRIAVVGASGRMGRTLIESAKQQQVIILGAAIERTGSSLIGIDAGVLAGVGAMNVAITDSLDKVVNDFDVLIDFTSPESSIIHLDWCAKNHKAIVIGTTGFNHAQKEQINAYSEQVPVVLAPNMSVGVNVMWKLLALATEVMGDYTDIEIIEAHHRHKKDAPSGTALKMGEIIAQTLGRDLEQCAVFGREGITGERDPNTIGFATVRAGDIVGEHTAMFADIGERLEITHKASSRMTFANGAMRAAFWLSDQNAGLYDMQQVLGLN
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
Q086I8
B6SHG7
TRMB_MAIZE
tRNA(m7G46)-methyltransferase
Zea
MTRTNDASGGGKLPRKRFYRARAHSNPLSDSHFPVPISPEEVDLSQHYPRYFPADKGSDGEEAAAPQQIRFADVGCGFGGLLVGLSPLFPDTLMIGMELRDKVTEYVKERILALRGANPGQYDNISVVRTNSMKYIPNYFRKAQLTKMFFLFPDPHFKEKNHRRRVISMQLLDEYAYVMEVGGIIYTITDVEELGEWMRSCLEKHPLFETVPEEEIKADPVFKLLSTATEESQKVARNGGQTFYAIFRRISLQEE
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
B6SHG7
Q9TM28
ATPF_CYACA
ATPase subunit I
Cyanidium
MRSQSLNFVASNTTSDFISNLLESNVINIIILISLLIYLGKRTIVTNLNDRKLNIQCSILEAEKKLSQAQLRLAEAEKKITESEEIISILKHEAKIAANKIKELIVNNAKRKIDKIILDGKTIIANTEIEIMNQIKNRIISTAIDKTKIKLTKNLQAETIERITDNKITFLNNNL
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
Q9TM28
Q56064
ENTD_SALTY
Enterochelin synthase D
Salmonella
MLTSHFPLPFAGHRLHIVDFDASSFREHDLLWLPHHDRLRSAGRKRKAEHLAGRIAAVHALREVGVRTVPGMGDKRQPLWPDGLFGSISHCATTALAVISRQRIGIDIEKIMSQHTATELAPSIIDSDERQILQASLLPFPLALTLAFSAKESVYKAFSDRVTLPGFNSAKVTSLTATHISLHLLPAFAATMAERTVRTEWFQRDNSVITLVSAITRVPHDRSAPASILSAIPR
Involved in the biosynthesis of the siderophore enterobactin (enterochelin), which is a macrocyclic trimeric lactone of N-(2,3-dihydroxybenzoyl)-serine. The serine trilactone serves as a scaffolding for the three catechol functionalities that provide hexadentate coordination for the tightly ligated iron(2+) atoms. Play...
Q56064
A9MJE5
BIOF_SALAR
8-amino-7-ketopelargonate synthase
Salmonella
MSWQQRVDDALTARRATDTLRRRYVVSQGAGRWLVANGRQYLNFSSNDYLGLSQHPQIIRAWQQAATRFGVGSGGSGHISGYSVAHQALEEELAQWLGYPRALLFISGFAANQAVITALMKKNDRIVADRLSHASLLEAANLSPAQLRRFIHNDTQHLSRLLQSPCPGQQLVVAEGIYSMDGDSAPLAEIQQITHKHHAWLLVDDAHGIGVTGVEGRGTCWLQGMKPELLVVTFGKGFGVSGAAVLCSESVANYLLQFARHLVYSTSMPPAQAQALSASLAVIRSDEGCERREKLADLVKRFRAGVNASRFTLLNAHSAI...
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
A9MJE5
Q0TA96
STHA_ECOL5
NAD(P)(+) transhydrogenase [B-specific]
Escherichia
MPHSYDYDAIVIGSGPGGEGAAMGLVKQGARVAVIERYQNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYSDHSRLLRSSFADILNHADNVINQQTRMRQGFYERNHCEILQGNARFVDEHTLALDCPDGSVETLTAEKFVIACGSRPYHPTDVDFTHPRIYDSDSILSMHHEPRHVLIYGAGVIGCEYASIFRGMDVKVDLINTRDRLLAFLDQEMSDSLSYHFWNSGVVIRHNEEYEKIEGCDDGVIMHLKSGKKLKADCLLYANGRTGNTDSLALQNIGLETDSRGQLKVNSMYQTAQPHVYAVGDVIGYPSLAS...
Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation.
Q0TA96
Q12ZS7
KAD_METBU
Adenylate monophosphate kinase
Methanococcoides
MNVVLFGPPGAGKGTQAKELDKHYQIPHISTGDILRANVRDGTKLGKEAKGYMDKGELVPDEVLIGVIKNRLAESDCKPGYLLDGYPRTTPQADALSSILVEIGMPLEVVLNIDVADEELVTRLCGRYVCTCGESYHMKFNPPKKENVCDACGADLYQRDDDKEDVIRQRLDSYKEKTQPLISYYGEKGLLVDIDGTGAIDRIFSDICKTLDQYK
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Q12ZS7
A7HDY3
RISB_ANADF
6,7-dimethyl-8-ribityllumazine synthase
unclassified Anaeromyxobacter
MNVYEGSLVATGLKVGLVVARFNSLVTEQLLVGAADALRRHGVKDGDIDVFRCPGTFELPALLRRVARSARYDAVVALGAVIRGGTPHFEYVAGEATKGVAQIALESDCAVSMGILTCDTLEQALERAGVKAGNKGAEAAVAAVEQANVLREAAKVPSPRRAE
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
A7HDY3
Q93Y16
DEAH4_ARATH
DEAH RNA helicase homolog PRP22
Arabidopsis
MANLPILQFEEKIVETVEKNSVVVIIGETGSGKSTQLSQILHRHGYTKSGVIAITQPRRVAAVSVARRVAQELDVPLGEDVGYAIRFEDRTTSKTRIKYLTDGVLLRESLSNPMLDDYSVIILDEAHERSLNTDILLGLVKRLVRIRASNFKVLITSATLDGEKVSEFFSGCPVLNVPGKLYPVEILYSKERPVSYIESSLKVAIDIHVREPEGDILIFMTGQDDIEKLVSRLEEKVRSLAEGSCMDAIIYPLHGSLPPEMQVRVFSPPPPNCRRFIVSTNIAETSLTVDGVVYVIDSGYVKQRQYNPSSGMFSLDVIQI...
May be involved in pre-mRNA splicing.
Q93Y16
P43305
PRVU_CHICK
Parvalbumin-3
Gallus
MSLTDILSPSDIAAALRDCQAPDSFSPKKFFQISGMSKKSSSQLKEIFRILDNDQSGFIEEDELKYFLQRFECGARVLTASETKTFLAAADHDGDGKIGAEEFQEMVQS
Binds two calcium ions.
P43305
A8GYW6
RL1_SHEPA
50S ribosomal protein L1
Shewanella
MAKLTKRARLIREKVEATKSYDINEAVALLKELATAKFLESVDVAVNLGVDPRKSDQNVRGATVLPHGTGRDVRVAVFTQGANAEAAKEAGAELVGMDELAAQIKAGEMNFDVVIASPDAMRVVGMLGQILGPRGLMPNPKTGTVTPNVAEAVKNAKAGQVRYRNDKNGIIHTTIGKVDFEPAQLKENLEALLGALKKAKPAAAKGVFIKKVSISTTMGAGVAVDQGTLDDAK
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
A8GYW6
Q5M7K3
G6PT3_XENTR
Solute carrier family 37 member 2
Silurana
MRSSLAPAIRLMQSVSRDSCYRGFIIVMTFLFYTCYHMSRKPISIVKGQLHRNCSALPSPPNISANDTTWCSWAPFENSNYKELLGSLDTAFLVSYAIGMFFSGIFGERLPLRYYLSGGMIICGIFTSFMGLGYYWNIHALWYYILFQILNGLAQTTGWPSVVTCMGNWFGKGKRGFIMGIWNSHTAVGNILGSLIAGAFVSTAWGLSFIVPGIIIAAFGIFCFFFLVEYPEDVGCTPPQQPEDTKENLEDMPVSYNSTDTICKSTESNEDDSGNAHTETEHPQAISFFGALRIPGVVEFSLCLLFAKLVSYTFLYWLPL...
Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction.
Q5M7K3
A1SSY7
NQRE_PSYIN
NQR-1 subunit E
Psychromonas
MEHYISIFVRSIFMENMALAFFLGMCTFLAVSKKVKTSMGLGVAVIVVLGISVPVNQIIYFNLLAPGALAWAGFPAADLSFLGFITFIGVIAALVQILEMVLDKYFPALYQALGIYLPLITVNCAILGGVLFMVQREYNLMESLVYGVGSGVGWMLAIVLLAGIREKMKYSDVPAGLRGLGITFTTAGLMAIAFMSFSGIQL
NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na(+) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.
A1SSY7
Q580X6
PIF5_TRYB2
DNA repair and recombination helicase PIF5
Trypanosoma
MLSRLSAVWRPSRVALRIQRVDFTTCGNRLNRSTQPNEPPLVSGIAARSRTAKAEPVEKRGRAAIKIDSPPPPLEPPRISEEHMTRRRKVGGGKTKAAAVTKSKQRRSGRTVGASAFNTARRANGIEGSAPGKGGASDVAIDDDDDEKLVDEESKQLMQLLKEEALRREEEKKKRLRAKAAAEPTEVTDDKEYLSKLGVAERTQPVGTEAKISAQGKAEGASEGQTHFSDADADSQLPILTSLSPEQQRALRLALKGRNLFITGGAGSGKSLLIREIVYQLRHNKRRCVYVTATTGVAALNVRGSTVNSFAGVKFGDGDA...
DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of mitochondrial (kinetoplast) genome stability. Involved in processing of minicircle Okazaki fragments.
Q580X6
Q5WCM4
RPIA_ALKCK
Phosphoriboisomerase A
Alkalihalobacillus
MDQLKRMAAEAAAEYVKDGMKIGLGSGSTVFEFVRVLGEKAKEGLNIQAVAASRKTEALAKACGIHIIDFPTMEKLEVAFDGADEIAPGLMLLKGGGGSLLREKLVAAAAKRLVVLADESKLVEELGAFKLPVEIIPFGWETTAMRIEALGGVASLRQTGKSPFVSDNHNWILDCDFGNIRDPYSLHEKVKKLVGVVETGLFLDMACEAIVASKNGIHHITKGDEFNV
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Q5WCM4
Q4QNP9
METJ_HAEI8
Met regulon regulatory protein MetJ
Haemophilus
MADWDGKYISPYAEHGKKSEQVKKITVSIPIKVLEILTNERTRRQLKSLRHATNSELLCEAFLHAFTGQPLPTDADLMKERNDEIPEDAKVLMRELGVDPESWEY
This regulatory protein, when combined with SAM (S-adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis.
Q4QNP9
A6LD84
BIOB_PARD8
Biotin synthase
Parabacteroides
MTIEEAKQHILEGGKITEEQALSLANHPDKEALYEAAHQITRHFMGNKFDTCSIINAKSGNCSEDCKWCAQSGHYKTLVNLYPLLPAKECVYHAVYNRKQGIRRFALVTSGKRVSDKELEQITDTIRQIKRQSDIKCCASMGLLTRSQLQSLYDSGVENYHCNIETAPSYFRQLCSTHTIEQKMETIHTAREIGFRICCGGIIGMGETMKERIEMACFLQKEGVLSIPLNLLQPIPGTPMENTQILEEEEWLTTIALFRLINPNAFLRFSGGRAQLSEVTQRKSLHIGINSAIIGDLLTTIGSKVEEDKVLFTSEGYSLT...
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
A6LD84
P46527
CDN1B_HUMAN
p27Kip1
Homo
MSNVRVSNGSPSLERMDARQAEHPKPSACRNLFGPVDHEELTRDLEKHCRDMEEASQRKWNFDFQNHKPLEGKYEWQEVEKGSLPEFYYRPPRPPKGACKVPAQESQDVSGSRPAAPLIGAPANSEDTHLVDPKTDPSDSQTGLAEQCAGIRKRPATDDSSTQNKRANRTEENVSDGSPNAGSVEQTPKKPGLRRRQT
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA . Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the as...
P46527
Q86BW2
VBP2_ASCSS
Vanadium-binding protein 2
Ascidia
MSKVIFALVLVVVLVACINATYVEFEEAYAPVDCKGQCTTPCEPLTACKEKCAESCETSADKKTCRRNCKKADCEPQDKVCDACRMKCHKACRAANCASECPKHEHKSDTCRACMKTNCK
Acts as a vanadium reductase which may form an electron transfer cascade in conjunction with NADPH and glutathione through thiol disulfide exchange reactions. Partial cleavage of its disulfide bonds results in the reduction of V(5+) to V(4+). Binds up to 24 V(4+) ions per protein at pH 7.5. Also binds Fe(3+) and Cu(2+)...
Q86BW2
Q9SCK6
NAC62_ARATH
Protein NTM1-like 6
Arabidopsis
MNQNLHVLSMDSLPVGLRFRPTDEELIRYYLRRKINGHDDDVKAIREIDICKWEPWDLPDFSVIKTKDSEWLYFCPLDRKYPSGSRQNRATVAGYWKATGKDRKIKSGKTNIIGVKRTLVFHAGRAPRGTRTNWIIHEYRATEDDLSGTNPGQSPFVICKLFKKEELVLGEEDSKSDEVEEPAVSSPTVEVTKSEVSEVIKTEDVKRHDIAESSLVISGDSHSDACDEATTAELVDFKWYPELESLDFTLFSPLHSQVQSELGSSYNTFQPGSSNFSGNNNNSFQIQTQYGTNEVDTYISDFLDSILKSPDEDPEKHKYV...
Transcriptional activator activated by proteolytic cleavage through regulated intramembrane proteolysis (RIP) . Transcriptional activator involved in response to cold stress. Mediates induction of pathogenesis-related (PR) genes independently of salicylic signaling in response to cold. Binds directly to the PR gene pro...
Q9SCK6
P44087
SLAM1_HAEIN
Surface lipoprotein assembly modifier 1
Haemophilus
MSIQTKFILFLSSSLFLTPYSVATEKSPQPHDGRLDEQLHLAKPNLPQKTPALLTNNNPSKLSITKEELAKHPDLIIRGLIPAVLQNNGEAVQLLLPLYQPLPKKDPFLLEWAEAIDLREKGYFSDSVKAYRHLFSQKTDLLPLRYQLAQALFLNNDNEAAKDQFQKLRAEQVSSDSVKIIEQYLSALNQRDQWKIQGGFSFLNESNINNAPKAGTKIGNWTAWEKESARGFSYFGNAEKKWSLPHNHFTKLSLEGSGKYYWDNKKYNEFNARAGVGLGYQTARFELSLMPFTEKRWYAGGSSGGNAMKQYSKNSGARLD...
Required for correct export to the cell surface of some cell outer membrane lipoproteins.
P44087
A0A384
CCSA_COFAR
Cytochrome c biogenesis protein CcsA
Coffea
MIFSTVEHILTHISFSIVSIIITMRLISFFLVDGIVQLYDSSEKGMIVTFLCLTGLLVTRWTYSGHFPLSNLYESLIFLSWSFSLIHIVPYFKKNKKYLSTITGSSVVFTQGFTTSGLLTEIDQSSILVPALQSEWLIMHVTMMILGYASLLCGSLLSIALLVITFRKNKKILYRNNLLLNESFFFVEIEYMNERSNLLQNTSFFSAKNYYRSQLIQQLDYWSSRGISLGFIFLTIGILSGAVWANEAWGSYWNWDPKETWAFITWIIFAIYLHTRTTRNPKCANSAIVASIGFLIIWICYFGVNLLGIGLHSYGSFTLL...
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
A0A384
Q8X825
BIOB_ECO57
Biotin synthase
Escherichia
MAHRPRWTLSQVTELFEKPLLDLLFEAQQVHRQHFDPRQVQVSTLLSIKTGACPEDCKYCPQSSRYKTGLEAERLMEVEQVLESARKAKAAGSTRFCMGAAWKNPHERDMSYLEQMVQGVKAMGLEACMTLGTLSESQAQRLANAGLDYYNHNLDTSPEFYGNIITTRTYQERLDTLEKVRDAGIKVCSGGIVGLGETVKDRAGLLLQLANLPTPPESVPINMLVKVKGTPLADNDDVDAFDFIRTIAVARIMMPTSYVRLSAGREQMNEQTQAMCFMAGANSIFYGCKLLTTPNPEEDKDLQLFRKLGLNPQQTAVLAG...
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Q8X825
Q6P4I2
WDR73_HUMAN
WD repeat-containing protein 73
Homo
MDPGDDWLVESLRLYQDFYAFDLSGATRVLEWIDDKGVFVAGYESLKKNEILHLKLPLRLSVKENKGLFPERDFKVRHGGFSDRSIFDLKHVPHTRLLVTSGLPGCYLQVWQVAEDSDVIKAVSTIAVHEKEESLWPRVAVFSTLAPGVLHGARLRSLQVVDLESRKTTYTSDVSDSEELSSLQVLDADTFAFCCASGRLGLVDTRQKWAPLENRSPGPGSGGERWCAEVGSWGQGPGPSIASLGSDGRLCLLDPRDLCHPVSSVQCPVSVPSPDPELLRVTWAPGLKNCLAISGFDGTVQVYDATSWDGTRSQDGTRSQ...
May play a role in the regulation of microtubule organization and dynamics .
Q6P4I2
Q3ZBK2
PXL2A_BOVIN
Redox-regulatory protein FAM213A
Bos
MGMWSIGAGAIGVAALALLLANTDMFLAKPEKAALEYLEDIDLKTLEKDAVTFKAKALWEKNGAVIMAVRRPGCFLCREEATDLSSLKPKLDELGVPLYAVVKEHIKNEVKDFQPYFKGEIFLDENKKFYGPQRRKMMFMGFVRLGVWQNFFRAWNGGFSGNLDGEGFILGGVFVMGPGKQGILLEHREKEFGDKVNLTSVLEAARKIRPQTSASEKQ
Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammat...
Q3ZBK2
A0M0D9
RL9_GRAFK
50S ribosomal protein L9
Gramella
MEVILKKDVDNLGFKDDLVAVKNGYGRNYLIPHGFAELATPSARKVLSETLKQRAYKEQKHIDEAKKQAEKLNNLEIKITAKAGAGDKLFGSITNGDLADALAKEGVEIEKKYISIAGGNIKRLGQYDATLRFHREVISNFSFDVVGDA
Binds to the 23S rRNA.
A0M0D9
J9MJK9
TAL1_FUSO4
Transaldolase
Fusarium oxysporum species complex
MSSSLEQLKATGTTVVSDSGDFASIGKYKPQDATTNPSLILAASKKAEYAKLIDVAIDYAKQKGGPIDQQVDDALDRLLVEFGKEILKIIPGKVSTEVDARYSFDTEASVNKALHLIELYGEQGISKDRILIKIAATWEGIKAAEILQRDHGINTNLTLMFSLVQAIGAAEAGAYLISPFVGRILDWFKASTKKEYSKEEDPGVQSVKTIFNYYKKYGYNTIVMGASFRNTGEITELAGCDYLTISPNLLEELLNSNEPVPKKLDASQASSLDIEKKSYINDEALFRFDFNEDQMAVEKLREGISKFAADAVTLKSILKE...
Transaldolase important for the balance of metabolites in the pentose-phosphate pathway. Involved in xylose fermentation to ethanol.
J9MJK9
Q58771
RLME_METJA
rRNA (uridine-2'-O-)-methyltransferase
Methanocaldococcus
MGRKDKRWVLQRKRDFYYKLAKKLKYRSRASFKLMQLNEKFNVIKPGKIVLDLGCAPGGWMQVAREIVGDKGFVIGIDLQPVKPFEYDNVVAIKGDFTLEENLNKIRELIPNDEKKVDVVISDASPNISGYWDIDHARSIDLVTTALQIATEMLKERGNFVAKVFYGDMIDDYVNLVKKYFEKVYITKPQASRKESAEVYVIAKRYTGKKWEEEDKIKRVKKVENEDNELLAKKIKEIRKLKSKK
Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Q58771
Q2N7E1
ARGB_ERYLH
NAG kinase
Erythrobacter
MTATEKTELAKAEVLIEALPYFQRYAGRTFVVKYGGHAMGDPKAAREFAEDIVLLKAVGINPVVVHGGGPQIGAMLKRLGVESTFVDGLRVTDKATAEVAEMVLSGAINKELVGWIAQAGGKAMGVSGKDGSLVTATKLERTTRDPESQIEQILDLGFVGEPTHVDTTILDTAVSAGMIPVVAPIGAGEDGHTYNINADTMAGAIAAALGAARLFLLTAVKGVLDKQGGLLTDLTPAQIAKLKDDGTISGGMIPKLDTCVHAVEAGCEAAVVLDGRVPHAMLLEFFTARGAGTLIRADD
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
Q2N7E1
Q28943
DPYD_PIG
Dihydrouracil dehydrogenase
Sus
MAPVLSKDVADIESILALNPRTQSHAALHSTLAKKLDKKHWKRNPDKNCFHCEKLENNFGDIKHTTLGERGALREAMRCLKCADAPCQKSCPTHLDIKSFITSISNKNYYGAAKMIFSDNPLGLTCGMVCPTSDLCVGGCNLYATEEGSINIGGLQQFASEVFKAMNIPQIRNPCLPSQEKMPEAYSAKIALLGAGPASISCASFLARLGYSDITIFEKQEYVGGLSTSEIPQFRLPYDVVNFEIELMKDLGVKIICGKSLSENEITLNTLKEEGYKAAFIGIGLPEPKTDDIFQGLTQDQGFYTSKDFLPLVAKSSKAG...
Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.
Q28943
Q1RMR4
RAB15_BOVIN
Ras-related protein Rab-15
Bos
MAKQYDVLFRLLLIGDSGVGKTCLLCRFTDNEFHSSHISTIGVDFKMKTIEVDGIKVRIQIWDTAGQERYQTITKQYYRRAQGIFLVYDISSERSYQHIMKWVSDVDEYAPEGVQKILIGNKADEEQKRQVGREQGQQLAREYGMDFYETSACTNLNIKESFTRLTELVLQAHRKELEGLRTRANHELALAELEEDEGKPEGPANSSKTCWC
May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal. EHBP1L1.
Q1RMR4
C9Z2Z3
MSHC_STRSW
Mycothiol ligase
Streptomyces
MHAWPASEVPVLPGKGRDLRIHDTATDGLITLDPGPVARIYVCGITPYDATHMGHAATYNAFDLVQRVWLDTKRQVHYVQNVTDVDDPLLERAARDDIDWVALAEKETALFREDMTALRMLPPRHYIGAVEAIPGIVPLVERLLASGAAYELEGDVYFSVEADPDFGKVSRLDAATMRLLSAERGGDPDRAGKKNPLDPMLWMAAREGEPSWDGGSLGRGRPGWHIECVAIALDHLGMGFDVQGGGSDLAFPHHEMGASHAQALTGEFPMAKAYVHAGMVALHGEKMSKSKGNLVFVSALRRDGVDPAAIRLALLAHHYR...
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
C9Z2Z3
P36119
RQT4_YEAST
RQC trigger complex subunit RQT4
Saccharomyces
MTRKQAIDYAIKQVPQILPLEESDVKALCEQVLSTSSDDPEQIASKFLEFLGHEDLSFEFVMKFNELLNQNDKKEEKKTKNVHLEHTAPTSWKNESKQPTNNYINKKGDEKPKKLKDEKKSSTTRPTVQPSNQSTQSNPIKEKKEHRSKGKLQSLQEIDEAIKMLELRDSGSSKNCNCQGTRHPVFDIAPNCLHCGKVVCVIEGLNKGKCGHCHEQLISDNERTQMVEILNQEKNELNGSSSSLSNASNGANVPKKKTKTYKITSGMGKNLFAEQDKLFDFIERKRERERKRNEVLKLQEEKEESEAKERQASEHDHKAE...
Functions as part of the RQC trigger (RQT) complex that activates the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation.
P36119
B8AME2
CATA3_ORYSI
Catalase isozyme C
Oryza sativa
MDPYKHRPSSSFNGPLWSTNSGAPVWNNNNSLTVGSRGPILLEDYHLVEKLANFDRERIPERVVHARGASAKGFFEVTHDITHLTCADFLRAPGVQTPVIVRFSTVIHERGSPETLRDPRGFAIKFYTREGNWDLVGNNFPVFFIRDGMKFPDMVHSLKPNPKSHVQENWRILDFFSHHPESLHMFTFLFDDIGIPADYRHMDGSGVNTYTLVNRAGKSHYVKFHWKPTCGVKSLLDDEAVTVGGTNHSHATQDLYDSIAAGNFPEWKLFIQTIDPDHEDRFDFDPLDVTKTWPEDIVPLQPVGRMVLNRNIDNFFSENE...
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Responsible for the redox homeostasis in leaves. Prevents nitric oxide (NO) accumulation and subsequent NO-mediated leaf cell death as well as the S-nitrosylation of specific proteins (e.g. glyc...
B8AME2
A0B6K7
AROD_METTP
Type I dehydroquinase
Methanothrix
MCLRELDLNGLRIKTPAIVASLGADAERVASRAESEGADIIEVRLDLLADPDVIRDIRSTVSLPLIATNRIASEGGSFRGSEERRISILRDASRFSDIIDIELMAPGRDMLLKNISCPALISYHDFSGVPDNLKSIIEDAMRAGADLVKIAVTPHSMQEALAILRILLDVDCPLCIIGMGAVGRHLRAVAPLYGSLLTYGYVTGPTAPGQMSVRELDTALRCLGAR
Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.
A0B6K7
Q8C0X7
SO6C1_MOUSE
Solute carrier organic anion transporter family member 6C1
Mus
MAHVRNKKSDDKKAMVVAKEDTNKSESEGVTKLQTYLKTIPIAKKKFAKLPKRKKSPTSAELLLIDPRYSASKEGPLGLGPIVLPFVQRFNNIDGFMTLYVAAVLIHGALFAVVDMTLNIYQVQFSLTRTEWYLMDFSDYIASFVVAIIIAHFGSKGNRTRWIAASCILMGLESMLFAFPFFTYEIIIPGRQSIELCMEENEKRNIICGNSVPNRSKCIYFHIAGQCIHGIAGMPIYILGITFIFDHIPTSSCGFYLAIGHSAYLIGYLLGMVGGLQNFQPPPKEKTVEIEPAKVYQLLQSGWWKTFLIIAAISFCVSFM...
Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation.
Q8C0X7
P0DTY1
C619_CONCL
O1_cal6.19
Californiconus
MKVTCVLVLTLMALTVCQVATAYCINVGMCIYDGYCCSNRCWGGMCSPWR
Probable neurotoxin.
P0DTY1
A6UUW0
PCNA_META3
Proliferating cell nuclear antigen homolog
Methanococcus
MFKAVMNAKNFKKIIDSISNLVDEICFEVDELGIKANAMDPSHVALISVNIPKESFDEYVSDTHDIGVDLEALKKIMNRAKPNEKLMLELDMEKNKLDIILKNEGTRKFSISLYDVSSSNVKVPEIGYPNEVMIKAGTIVESLKDAELVNDHVSLKITEDGKFIIYSKGDINTNETVLDRDNESIIELKISESSKSTYNLAYLKDITKATSSEDILHIHLGTDMPVKIEYIIGDTKLIYLLAPRIES
Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
A6UUW0
Q8K352
SASH3_MOUSE
SH3 protein expressed in lymphocytes
Mus
MLRRKPSNASDKEPTQKKKLSLQRSSSFKDFAKSKPSSPVVSEKEFNLDDNIPEDDSGVLTPEDSGKSGKKLGKKWRAVISRTMNRKMGKMMVKALSEEMGDTLEEGSASPTSPDCSLDSPGPEKMALAFTEQEEREPPSLSRQTSTGSELCSPGPGSGSFLEESPAPQYTGPFCGRARVHTDFTPSPYDHDSLKLQKGDVIQIVEKPPVGTWLGLLNGKLGSFKFIYVDVLPEEAVGPVRPSRRQSKGKRPKPKTLHELLERIGLEEHTSTLLLNGYQTLEDFKELRETHLNELNIMDPQHRAKLLTAAELLLDYDTGS...
May function as a signaling adapter protein in lymphocytes.
Q8K352
Q7MVU8
ISPE_PORGI
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Porphyromonas
MIVFPNAKINLGLQVVAKRADGYHNIETVFYPIPLTDALEIEVREDTCDRLSVHGVPIDAATEDNLVMKAVMALRRKFDFPPLTIELIKHIPSGAGLGGGSSNASFMLKLVRDYFSLPIDDEELAAIALTIGADCPFFVGNRPVLATDLGQVFTPLPNFSLSGLHIAIVKPPIHINTAAAYKGLKHVGKRETMPDEIVYMPVEEWRGKLVNDFEESLFPEHPRLAELKEMLYRSGALYAAMSGSGSALFGLFREKPQLDKAAITDCFRWQSIIP
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Q7MVU8
O81270
PXG1_ARATH
Embryo-specific protein 1 (ATS1)
Arabidopsis
MGSKTEMMERDAMATVAPYAPVTYHRRARVDLDDRLPKPYMPRALQAPDREHPYGTPGHKNYGLSVLQQHVSFFDIDDNGIIYPWETYSGLRMLGFNIIGSLIIAAVINLTLSYATLPGWLPSPFFPIYIHNIHKSKHGSDSKTYDNEGRFMPVNLELIFSKYAKTLPDKLSLGELWEMTEGNRDAWDIFGWIAGKIEWGLLYLLARDEEGFLSKEAIRRCFDGSLFEYCAKIYAGISEDKTAYY
Calcium-binding peroxygenase involved in the degradation of storage lipid in oil bodies. May be involved in the interaction between oil bodies and vacuoles during seed germination and in the oxylipin signaling pathways and plant defense responses. Can catalyze sulfoxidation of thiobenzamide, hydroxylation of aniline, e...
O81270
Q5SJ85
SEPBH_THET8
Protein SpeB homolog
Thermus
MRLVFGEKDTPYEEARVVVLPVPYDLSLSFLPGARRGPEAILLASRELEPFLLELGAAPEEVGIHAAEPVPWVAGMAEESHRLIREEALRHLRAGKWVVALGGDHSVTHPLVQAHREALGDFSLLHVDAHADLYPEWQGSVYSHASPFYRLLTEGFPLVQVGIRAMDRDSLRLARKKGVALFPAHRIHREGLPLDEILRALGKRVYISLDFDALDPSLMPSVGTPLPGGLSYRQVVDLLEAVFREKEVVGMDFVELSPNGQFHAEMTAAQLVYHAIGLKGLQAGWLSREVDHI
Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the decarboxylation of N1-(3-aminopropyl)agmatine to y...
Q5SJ85
A8AIH6
SERC_CITK8
Phosphohydroxythreonine aminotransferase
Citrobacter
MAQVFNFSSGPAMLPAEVLKLAQQDLRDWHGLGTSVMEISHRGKEFIQVAEEAEQDFRDLLSIPSNYKVLFCHGGGRGQFAAIPLNILGDKTSADYVDAGYWAASAIKEAKKYCSPNVIDAKVTVDGLRAVKPMSEWQLSDNAAYVHYCPNETIDGIAIDETPNFGSDVVVAADFSSTILSAPLDVSRYGVIYAGAQKNIGPAGLTIVIVREDLLGKANIACPSILDYTVLNDNDSMFNTPPTFAWYLSGLVFKWLKAQGGVAAMNKINQQKAELLYGVIDNSDFYRNDVAKSNRSRMNVPFQLADSALDKVFLEESFAA...
Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.
A8AIH6
A4TBX3
NUSB_MYCGI
Antitermination factor NusB
Mycolicibacterium
MPDRKGDRGRHQARKRAVDLLFEAEARGITAAEVAEARNALADNGADDIAPLNPYTVTVARGVTDHAAHIDDLISAHLQGWTLDRLPAVDRAVLRVAVWELLHAVDVPEPVAVDEAVELAKQLSTDDSPGFVNGVLGQVMLVTPQIRAAAAAVQASPDSGSATP
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
A4TBX3
Q91WM6
EVA1A_MOUSE
Transmembrane protein 166
Mus
MKLPLSPSTEPVATEPLGMALLSSILAAWSYISENPERAALYFVSGVCIGLFLTLAALVMRISCHTDCRRGPRRRCLQDRECSDSSDSEDGSEDTASDLSVRRHRRFERTLNKNVFTSAEELERAQRLEERERIIREIWMNGQPEVPGTRSLNRYY
Acts as a regulator of programmed cell death, mediating both autophagy and apoptosis.
Q91WM6
P24956
CYB_EQUGR
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Equus
MTNIRKSHPLIKIINHSFIDLPAPSNISSWWNFGSLLGICLILQILTGLFLAMHYTSDTTTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLFIHVGRGLYYGSYTFLETWNIGIILLLTVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTTLVEWIWGGFSVDKATLTRFFAFHFILPFIITALVIVHLLFLHETGSNNPSGIPSDMDKIPFHPYYTIKDILGLLLLILLLLTLVLFSPDLLGDPDNYTPANPLSTPPHIKPEWYFLFAYAILRSIPNKLGGVLALILSILILALIPTLHTSKQRSMMFRPL...
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is...
P24956
A7UVN1
WUHO_ANOGA
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit wuho
Anopheles
MYDLKIYSSYIVAAIKDKIVFFSTDGAVLHTITVEQKAPVKDTDAGNEPNGNQTQPTPANVVTFEYCPTAKVLAVSLSDKTWRRYQLREEDGGKLCSAPLGEDITTARTIVSMKFVPKHGVLFGTDKSDCFEFGALDKTSEPQPKWILGHMSQILALAVSDDERFIVTSDRDEKIKVSSYPDCHNIECFCLGHTEYVGGIEIIPSEKLISVSGDRTLRLWDVTEGKELSKLSLKEPALDFTVQKVAEGCGMLCAVRSYVQNMVEVALVSYDKPDASELYDPLTIDESLIILNAGLSASLRLMLLTMEKESKRVRMLVYEF...
Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.
A7UVN1
Q92575
UBXN4_HUMAN
UBX domain-containing protein 2
Homo
MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETSVANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVA...
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD .
Q92575