accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q6FV98
TPO12_CANGA
Drug:H(+) antiporter TPO1_2
Nakaseomyces/Candida clade
MSSTSSDRPYDPLAPENEGVASSDVESTDSGEIRSYGPEEVLKNGSQIKDKGPALSKNSTQTSAVESAVAANRRLSKILTNTVDEPDVLEVDYSKCPPMGGGRPFPPTLPEKTQFEVTFDGPNDPLHPFNWPLRKKVMLCIILCLNCISITMGSSIFATGIRQICEIYHVIPVVAILGITLYVLGFAASPVIYAPLSEIYGRRGVLVISSFGFALFNFAVATAKDLQTIMICRFFAGFIGAAPLAVVPAAFADMFDTNIRGKAICLFSLGVFVGPILAPVIGSYITQHTTWRWLEYVIACFASAIFVAILFFFEESHHPS...
Multidrug resistance transporter involved in resistance to azole antifungal drugs such as the imidazoles miconazole, ketoconazole, and tioconazole; as well as the triazoles itraconazole and fluconazole . Also plays a role in the resistance to other antifungal drug families such as the polyene amphotericin B, the pyrimi...
Q6FV98
B9JCD8
AMPA_AGRRK
Leucyl aminopeptidase
Agrobacterium tumefaciens complex
MSVKFEISFAKTVRLNGGLAILLKDADSESPAGAAGADPANVFAKAARIARFTAKGLSSLDIVAPEGSPVDRIIVIGTGRAKELNAHDWLKLGGAAAARIRNVEKAAIFIDLPGVQAGGKAAADFALGMLLRAYSFDTYKTKKGDDDDKNGAQKPVKVTIVTPDVAAAKKLFAASEAIADGVILARDLVNEPPNVLGPVEFAAKAKALEKLGVEVEILTEREMRRLGMGALLGVAQGSVRPPRLVIMQWKGGKAKEKPVAFIGKGVVFDTGGISIKPAAGMEDMKGDMGGAAAVTGLMHTLAARGAKVNAIGVIGLVENM...
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
B9JCD8
A4IXW8
TRUA_FRATW
tRNA-uridine isomerase I
Francisella
MKNYLLQIEYFGKNYCGWQRQSHSPSVQESLEKALSKIANQNIEVTCAGRTDTGVHATSQIVNFYSNADRPLSAWQRGVNALLPQDIKILAVQQVDNNFNSRFTAINRTYNYIIYNSATSSPIFAEHCLWENRELDIDKMNQACEYLLGEQDFSSFRSSQCQSNTPFRNIQKAEFIKQGSFIVFEVVGNAFLHHMIRNLVGSLLKVGLGFESPEWIKVVLEAKDRTQAAETAKAHGLYFVGVEYPEFSFKRQIIKLFC
Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.
A4IXW8
Q8Z9N1
LSPA_SALTI
Signal peptidase II
Salmonella
MSKPLCSTGLRWLWLVVVVLIIDLGSKYLILQNFALGDTVGLFPSLNLHYARNYGAAFSFLADSGSWQRWFFAGIAIGICVILLVMMYRSKATQKLNNIAYALIIGGALGNLFDRLWHGFVVDMIDFYVGDWHFATFNLADTAICIGAALIVLEGFLPKPTAKEQA
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Q8Z9N1
Q6YXR9
NU2C_PHYPA
NADH-plastoquinone oxidoreductase subunit 2
Physcomitrium
MELELDLSFFYKTTILPECVLIFCLISILILDLILKIKDKNVFFFISLVSLLLSIFILIFQLKEEPVISFLGNFQADNFNKIFRIFIALCSILCIPLSIDFIKCTKLAITEFLIFLLTATIGGMFLCGANDLITIFVSLECLSLCSYLLSGYTKKDVRSNEAVMKYLLIGGTSSSILAYGFSWLYGLSGGEFQLQKIADGLVSTEMYNSFGSLLALVFIIVGIGFKLSLVPFHQWTPDVYEGSPTPVVAFLSVASKIAGLALLVRLFNIVFPFLPNQWHSLLEISAICSMILGNLVAITQTSMKRMLAYSSISQIGYLMI...
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translo...
Q6YXR9
B9DPC0
MUTL_STACT
DNA mismatch repair protein MutL
Staphylococcus
MGNIKELQTSLANKIAAGEVVERPGSVVKELLENALDAKATEINIEIKQSGIESIRVVDNGTGIEEDDLKLVFHRHATSKLHEDSDLFHIRTLGFRGEALASISSVAKVTLRTCTDGQSGHEIYAEDGAILEQKPAKAKKGTDILVESLFYNTPARLKYVKSLYTELGKITDIVNRMAMSHPNVRFTLTSDDKVLIKTNGSGRTNEVMAEIYGMKVAKDLVHITGDTSDYHLEGYVAKPEHSRSNRHYISIFINGRYIKNFVLNKAIVEGYHTLLTIGRYPICYINIEMDPILVDVNVHPTKLEVRLSKEEQLYQLIVQK...
This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part ...
B9DPC0
A1TKT9
METK_ACIAC
Methionine adenosyltransferase
Acidovorax
MANDFLFTSESVSEGHPDKVADQISDAILDAIFREDPRSRVAAETLTNTGLVVLAGEITTNAHVDYIQVARDTIKRIGYDNTDYGIDYKGCAVLVAYDKQSNDIAQGVDHASDDHLNTGAGDQGLMFGYACDETPELMPAPIYYAHRLVERQAQLRKDGRLPFLRPDAKSQVTMRYVDGKPHSIDTVVLSTQHHPDQSETATRMKASFIEAVIEEIIKPVLPKEWLQETKYLINPTGRFVIGGPQGDCGLTGRKIIVDTYGGACPHGGGAFSGKDPTKVDRSAAYAARYVAKNIVAAGLARQCQIQVSYAIGVARPINVT...
Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
A1TKT9
P31291
WNT8B_XENLA
Protein Wnt-8b
Xenopus
MFYTGSFWFIFFILPAIPFCHSWSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDKWNCPERTLQLSSHSGLRSDLNIHSTGASPAGSGLYDTGPTSPVWSINFNRILFSRLESHFNKTFLSRLQIPFPQGHTVQSATSLSTGFLSPANRETAFVHAISYAGVMYTLTRNCSLGDFDNCGCDDSRNGQLGGQGWLWGGCSDNVGFGETISKQFVDPLETGQDARAAMNLHNNEAGRKAVKSTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGNYLKEKYHKALKVDLFHGAGNSAASRGAIAETFRSISKKEIV...
Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in the initiation of dorsal axis development. May activate a Nieuwkoop center-like signaling pathway.
P31291
A2T309
PSBA_ANGEV
Photosystem II Q(B) protein
Angiopteris
MTASLERRESASLWGRFCDWITSTENRLYIGWFGVLMIPTLLTATSVFIIAFIAAPPVDIDGIREPVSGSLLYGNNIISGAIIPTSAAIGLHFYPIWEAASVDEWLYNGGPYELIVLHFLLGVACYMGREWELSFRLGMRPWIAVAYSAPVAAAAAVFLIYPIGQGSFSDGMPLGISGTFNFMIVFQAEHNILMHPFHMLGVAGVFGGSLFSAMHGSLVTSSLIRETTENESANAGYKFGQEEETYNIVAAHGYFGRLIFQYASFNNSRSLHFFLAAWPVVGIWFTALGISTMAFNLNGFNFNQSVVDSQGRVINTWADI...
Photosystem II (PSII) is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photoni...
A2T309
Q9LIA0
GGPPB_ARATH
Geranyltranstransferase 11
Arabidopsis
MATTLSSSSLFIQFRGRRYNSLSSFNNLQKRTVLSLSCALSSQGGDMIPPEGKSNDRNSAFDFKSYMIRKAESVSAALNVSVPLQEPLTIQEAVRYSLLAGGKRVRPLLCIAACELVGGDEATAMSAACAVEMIHTSSLIHDDLPCMDDADLRRGKPTNHKEFGEDMAVLAGDALLALAFEHMTFVSNGLVAPERMIRAVMELAKAIGTKGLVAGQVTDLCSQGLNPDDVGLERLEFIHLHKTAALLEAAAVLGAIMGGGTEEEIEKLRKYARCIGLLFQVVDDILDVTESTKELGKTAGKDVMAGKLTYPRLIGLERSR...
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate.
Q9LIA0
A8YUY2
CITD_LACH4
Citrate lyase gamma chain
Lactobacillus
MEIKTTAVAGTLESSDIQIMISKGSNGIEIDLESEVKKAYGDQIEKVITETLKKYGLENAKVKATDKGALDCVIKARTLAVAQRATETQDKPDLEVL
Covalent carrier of the coenzyme of citrate lyase.
A8YUY2
Q96IY4
CBPB2_HUMAN
Thrombin-activable fibrinolysis inhibitor
Homo
MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTADLIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYYEQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGIHAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRKNRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNINQIKAYISMHSYSQHIVFPY...
Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
Q96IY4
Q46IK7
RIMM_PROMT
Ribosome maturation factor RimM
Prochlorococcus
MFEKDKWMTIGEIVAPQGLRGDLRIKPSSDFPERFTKPGKRWIQKTDELPTEIKLTKGKLIPGKSIYVLSIEGVSTRSSAEEIIGWKLVIPIDSRPMLSKDEYHYHDLIGLEARRGPSKALIGYVTDLIKGGNDLLEIELVEGKKVLVPFVKEIVPEIEIKEKWLLINPPPGLLEL
An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosoma...
Q46IK7
K7QRJ5
PYRE3_STRRG
FAD-dependent [4+2] cyclase
Streptomyces
MSDTVIIAGGGPVGLMLACELGLAGVDTVVLERHDAPREPSRGGAINATVVELFTQRGIMESLRDDGFEFRMAHFAHIPLAPERVPGDRAFSFAVPHAQVERRLEERARSLGVRVRRSTEITSVRQTPDGVQVTTGDGEVVEGAYLVGCDGSASLVREQAGIPFPGVDPDFHGLWGDIKVEPGAPVLERIGARQYELGLCMVAPIGPDTVRVITGEFDVPSPPADQEVGFDELRAAVARIAGVELDGVPGWLSRWTATSRQAERYREGRILLAGDAAHTLFPLGGQALGTGIEDAVNLGWKLAATVQGWAPPSLLDSYHE...
Involved in the biosynthesis of the spirotetramate antibiotics pyrroindomycins. Catalyzes the intramolecular cyclization forming the dialkyldecalin moiety in pyrroindomycins, via an endo-selective [4+2] cycloaddition reaction.
K7QRJ5
Q6DB24
GHRB_PECAS
Glyoxylate/hydroxypyruvate reductase B
Pectobacterium
MKPSVILYKKVADDLRARLDQHFTVTELDAFPALDHPALATAEGIIGSGGKVDKDFLQHAPRLRAASTISVGYDTFNVDALNEKGVILMHTPTVLTETVADTVLALMLASARRVVEVVERVKAGEWKGGVGSDWFGTDVHHKTIGILGMGRIGLAVAQRAHFGFSMPVLYNARRHHAEAEERFNARHCDLDTLLAESDFLCITLPLTAETHHLIGREQLAKMKPSAILINIGRGAVVDEDALTEALVKGTIQAAGLDVFVKEPLPVDSPLLDLPNVVALPHIGSATHETRYDMAACAVDNLIAALSGQVKENCVNPQVLK
Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
Q6DB24
Q92QB5
HIS3_RHIME
Phosphoribosyl-AMP cyclohydrolase
Sinorhizobium
MTLTFASPPQDKAELESGPAFTPRFDEKGLITAVVTDARDGELLMVAHMNAEALSLTLETGFAHYYSRSRDRLWKKGESSGNLQTVREIRTDCDQDAVWLKVSVAGHDATCHTGRRSCFYRTVGVADGEAKVAITDDHRHFDPAQIYAGN
Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
Q92QB5
B9KAB8
GRPE_THENN
HSP-70 cofactor
Thermotoga
MSEKEKKDLSQECEELKEKYRELEEYAKRLKAEYENYREEVAREKRELIKNANEYLISRLIPILDDFERALNQKDHEESFYEGVKLIYKKLLNTLEKEGLSKIQVGETFDPFEYEAVERVETDDVEEYTVLEVLESGYKFHGKVLKPAKVKVAVRPRKKDEESPDKKE
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-b...
B9KAB8
A1A0S8
RS12_BIFAA
30S ribosomal protein S12
Bifidobacterium
MPTIEQLVRKGRQAKPKKSKTLALKGSPLRRGVCTRVYTTTPKKPNSALRKVARVRLSSGVEVTAYIPGEGHNLQEHSIVLVRGGRVKDLPGVRYHIVRGALDTQGVKDRKQGRSLYGAKKAK
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The com...
A1A0S8
A0AJ22
ACCD_LISW6
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Listeria
MLGDLFTKPKKRKYATIPSDGTKADVPEGIMTKCPECKKIMYTKELQKNLMVCNYCGFHHPIGAKVRIDMLVDEGSFEELDANLTTANPLGFENYMDRIEKDKQKSGLNEAIVTGHATIAGNPLVIAVMDSRFRMASMGSVVGEKILRAVEEADKTNKPFVVFTASGGARMQEGMISLMQMAKTSAAFKRFSNHGGLIITVMTHPTTGGVSASFASLGDYNFAEPGALIGFAGRRVIEQTVREELPEDFQTAEFLLKHGQLDDCISRLDLQNKLSFILRIHAKTPETGGESDGE
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
A0AJ22
Q5FFN4
ERA_EHRRG
GTPase Era
Ehrlichia
MNHVGRKCSMSAIVGTTNAGKSTLVNVLVGQKVAAVTPKVQTTRVRMHAVSNHENVQLIFIDTPGIFSPKTKLEKFLVKHAWMSLKGIENVIVLVDVKNYLNQHLKKIIDRIKHSNLNAILVLNKIDIVHQSIVSEVIEYMYSLYKFSKAFTISALYGIGIDKLVDYLCETSPYGPWLYNDDQISDAPLKFFMAEITREKLFITLRHELPYSLSVVTELVEEKEDNSLIIKQVIYVTKDSHKTIILGKKGEMVKKISMESKSDLENILQVKVHLFLFVKVREFWQNHLNECVGYAE
An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
Q5FFN4
Q64237
DOPO_MOUSE
Soluble dopamine beta-hydroxylase
Mus
MQAHLSHQPCWSSLPSPSVREAASMYGTAVAIFLVILVAALRGSEPPESPFPYHIPLDPEGILELSWNVSYVQEIIHFQLQVQGLRAGVLFGMSDRGEMENADLIMLWTDGDRAYFADAWSDRKGQIHLDSQQDYQLLQAQRTRDGLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQRVQLLKSEVPTPSMPEDVQTMDIRAPDILIPDNETTYWCYITELPPRFPRHHIIMYEAIVTEGNEALVHHMEVFQCAAESEDFPQFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPKEAG...
Conversion of dopamine to noradrenaline.
Q64237
A7Z5B4
BIOF2_BACVZ
8-amino-7-ketopelargonate synthase
Bacillus amyloliquefaciens group
MDFDGWLLGRLDAVKRDGLYRTLRTQETALKTKGQKRQTWASNDYLGLSKDERLITAAQTAMSRFGAGSGGSRLTTGNTVWHEKLEHTIADFKQTEAALLFSSGYLANIGVLASLPQKGDVILSDQLNHASIVDGCRLSKAETIVYRHIDMADLEKKLASVQARNRRFIVTDGVFSMDGTIAPLDRIMALAKQYQAFVIADDAHATGVLGENGGGTSDYFGVCPDVVIGTLSKAVGTEGGFAAGSNIFIDFLLNQARTFIFQTALPPSICAASHTAFDIISDMHDTRRELQSSVKMIKTRLADMGFTVRGGDTPIIPVII...
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
A7Z5B4
Q96RD0
OR8B2_HUMAN
Olfactory receptor OR11-309
Homo
MLARNNSLVTEFILAGLTDHPEFRQPLFFLFLVIYIVTMVGNLGLITLFGLNSHLHTPMYYFLFNLSFIDLCYSSVFTPKMLMNFVSKKNIISNVGCMTRLFFFLFFVISECYMLTSMAYDRYVAICNPLLYKVTMSHQVCSMLTFAAYIMGLAGATAHTGCMLRLTFCSANIINHYLCDILPLLQLSCTSTYVNEVVVLIVVGTNITVPSCTILISYVFIVTSILHIKSTQGRSKAFSTCSSHVIALSLFFGSAAFMYIKYSSGSMEQGKVSSVFYTNVVPMLNPLIYSLRNKDVKVALRKALIKIQRRNIF
Odorant receptor.
Q96RD0
P78055
FSAA_ECOLI
Fructose-6-phosphate aldolase A
Escherichia
MELYLDTSDVVAVKALSRIFPLAGVTTNPSIIAAGKKPLDVVLPQLHEAMGGQGRLFAQVMATTAEGMVNDALKLRSIIADIVVKVPVTAEGLAAIKMLKAEGIPTLGTAVYGAAQGLLSALAGAEYVAPYVNRIDAQGGSGIQTVTDLHQLLKMHAPQAKVLAASFKTPRQALDCLLAGCESITLPLDVAQQMISYPAVDAAVAKFEQDWQGAFGRTSI
Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze th...
P78055
Q0K609
RS12_CUPNH
30S ribosomal protein S12
Cupriavidus
MPTINQLVRKPRVSEVVKSKSPALENCPQRRGVCTRVYTTTPKKPNSALRKVAKVRLTNGFEVISYIGGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGSLDLQGVKDRKQARSKYGAKRPKAA
Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The com...
Q0K609
P15122
ALDR_RABIT
Aldose reductase
Oryctolagus
MATHLVLYNGAKMPILGLGTWKSPPGQVTEAVKTAIDLGYRHIDCAHVYQNENEVGVALQEKLKEQVVKREELFIVSKLWCTSHDKSLVKGACQKTLNDLKLDYLDLYLIHWPTGFKHGSEYFPLDAAGNVIPSDTDFLDTWEAMEGLVDEGLVKSIGVSNFNHLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIQYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIADKHKKTTAQVLIRFPMQRNLVVIPKSVTPARIAENFQVFDFELSSEDMTTLLSYNRNWRVCALVSCASHKDYPFHAEF
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathwa...
P15122
Q9N2N6
TBB_EUPFO
Beta-tubulin
Euplotes
MREIVHIQAGQCGNQIGAKFWEVISDEHGVDPTGTYHGDSDLQLERINVYFNEATGRKICPRAMLMDLEPGTMDSVRAGPFGQLFRPDNFVFGQSGAGNNWAKGHYTEGAELIDSVLDVVRKEAEGCDCLQGFQITHSLGGGTGSGMGTLLISKIREKYPDRIMETFSVFPSPKVSDTVVEPYNATLSVHQLVENADEVMCIDNEALYDICFRTLKPTTPTYGDLNHLVSAVISGVTSCLRFPGQLNSDLRKLAVNLIPFPRLHFFMIGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMCASDPRHGRYLTASAMFRGR...
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-...
Q9N2N6
B8I5W0
CH60_RUMCH
Chaperonin-60
Ruminiclostridium
MAKEIKFGEEARRSLEKGVNQLADTVKVTLGPKGRNVVLDKKFGSPLITNDGVTIAKEVELEDKFENMGAQLVKEVATKTNDVAGDGTTTATLLAQAIIREGMKNVAAGANPMILKKGLQKAVDTAVAGIKENSRKVKGKEDIARVATISANEELIGTLIADAMEKVTNDGVITVEESKTMGTNLEVVEGMQFDRGYLSAYMVTDTDKMEAVLDDPYILITDKKLTNIQDLLPILEEIVKQGKKLLIIAEDIEGEALTTLILNKLRGTFVCVAVKAPGFGDRRKAMLQDIAILTGGEVITEELGLDLKETQITQLGKARQ...
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
B8I5W0
Q9M2E0
RH12_ARATH
DEAD-box ATP-dependent RNA helicase 12
Arabidopsis
MNTNRGRYPPGVGTGRGAPPNPDYHQSYRQQQPPQDQQYVQRGYSQNPQQMQLQQQHQQQQQQQQWSRRPQLPGNASNANEVVQQTTQPEASSDANGQDWKATLRLPPPDTRYQTADVTATKGNEFEDYFLKRDLLKGIYEKGFEKPSPIQEESIPIALTGSDILARAKNGTGKTGAFCIPVLEKIDPNNNVIQAMILVPTRELALQTSQVCKELSKYLNIQVMVTTGGTSLRDDIMRLHQPVHLLVGTPGRILDLTKKGVCVLKDCAMLVMDEADKLLSAEFQPSLEELIQFLPQNRQFLMFSATFPVTVKAFKDRHLR...
ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping.
Q9M2E0
A5FJI6
LFTR_FLAJ1
Phenyalanyltransferase
Flavobacterium
MYYLFKDLFFPPVSEADEEGVLAIGGDLDPERLKLAYKSGIFPWFNEGEPILWWAPDPRMVLFFDELVISKSMRKILNKKIFKVTYNKNFKEVISNCQQIKREGQNGTWISNEMIEAYCELHKQGIAKSVEVWQDEVLVGGLYGIDLGHVFCGESMFSKVSNASKTAFIALALYLKKENYKLLDCQVYNSHLESLGCREIDREEFMSILKSK
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
A5FJI6
A5G0G6
LEUC_ACICJ
Isopropylmalate isomerase
Acidiphilium
MASTLFDKIWAAHVVDRMPDGTAVLYIDRHLVHEVTSPQAFEGLRMAGRKVRRVDATIAVADHNVPTEDRAAGIAEPESALQVATLEQNVAAFGVPYIPVTDARQGIVHVIGPEQGISLPGMTIVCGDSHTSTHGAMGALAFGIGTSEVEHVLATQTLLQKPAKNMLVRVDGTLPPGCSAKDIVLAIIGEIGTAGGTGHVIEYAGEAIRALDMAGRMTVCNMSIEAGARAGLIAPDETTFEYVRGRPYAPKGEALERAIDYWKTLASDEGAQYDRVVTIDASALVPQVTWGTSPETVVPITGHVPDPAAEPDAGRRAQME...
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
A5G0G6
Q9FKB5
KRP3_ARATH
KIP-related protein 3
Arabidopsis
MGKYMKKSKITGDISVMEVSKATAPSPGVRTRAAKTLALKRLNSSAADSALPNDSSCYLQLRSRRLEKPSSLIEPKQPPRVHRSGIKESGSRSRVDSVNSVPVAQSSNEDECFDNFVSVQVSCGENSLGFESRHSTRESTPCNFVEDMEIMVTPGSSTRSMCRATKEYTREQDNVIPTTSEMEEFFAYAEQQQQRLFMEKYNFDIVNDIPLSGRYEWVQVKP
Binds and inhibits CYCD2-1/CDKA-1 complex kinase activity. May target specifically CDKA-1.
Q9FKB5
Q21V18
RISB_ALBFT
6,7-dimethyl-8-ribityllumazine synthase
Rhodoferax
MLDANQGTLAASDSRLNGKKLRIGIVQARFNEPITNTLAQACKAELLALGVAEKHIDLVQVPGALEVPVALLALAEKLEYDALVAVGCIIRGETYHFELVANESGAGVSRVALDYQIPIANAILTTENLAQAIARQTEKGRDAARVAVEMANLLSDI
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
Q21V18
Q39V40
GPMA_GEOMG
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Geobacter
MKKLVLLRHGESVWNRENRFTGWTDVGLSEKGIEEAISAGRTLKEEGFVFDVAYTSVLKRAIKTLWLVLEEMDLMWIPEYRHWRLNERHYGALQGLNKAETAERHGMEQVMIWRRSYDIPPPPLTPDDQRFPGSDPRYASLLPEELPLTESLKDTVARFLPYWHETIAPAVKEGKRVLVTAHGNSLRALVKYLDLVSDSEIVNLNIPTGIPLVYELTDNMTPIRSYYLGDPDDVARASRMVADQIKK
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.
Q39V40
Q9PJW4
MENG_CHLMU
Demethylmenaquinone methyltransferase
Chlamydia
MTNFQDKPNIRIMFDSLAPTYDKINKILSLGLHLTWNHSFVSLLGRSDHLLDLCAGTGHVALSYIQKYPQASATLVDFSTKMLENVQECHPLAPFSYVISDVTSMPLPNDTFHLASMAYGLRNLSSPLEALKEVHRVLKPKGRLGILELTRPATYNPVHLLHKLYLNLVVPSVGRFYSGNSYAYSYLKESIRNLPCDTSLERVFHKSGLHIIRKRKLLFGTATIWILEK
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2).
Q9PJW4
Q6FWW0
CHZ1_CANGA
Histone H2A.Z-specific chaperone CHZ1
Nakaseomyces/Candida clade
MSEEKEVKPVVAENAEVPAKVEKKKRRRRNYDDYDAEVTESEKKKSKPSEASGKAGAAAAGDSDSESDIDDAKLDRLESNEDEEEDDLAEIDTSNIITTGRRTRGKIIDYKKTAKELDASEQKTDSAATEAAPGAADDEEDDDADFKE
Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.
Q6FWW0
A9I8F2
RUVA_BORPD
Holliday junction ATP-dependent DNA helicase RuvA
Bordetella
MIGRITGTLIEKLPPTICVDVNGLGYDIEVPMSTLYALPELGARVTLHTHLTVREDAHILYGFATAAERGAFRELIKVSGIGARTALSVLSGLSVSDLAQAITLQESGRLTRVPGIGKKTAERLLLEMRGKLGADIGATAHAVPDSQTDILNALLALGYSDKESQAALKKLPEGTGVSEGIRLALKALVR
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA...
A9I8F2
P50844
KDGR_BACSU
Kdg operon repressor
Bacillus
MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNIKKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMVCNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLKLDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNGLVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQDIGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGD...
Transcriptional repressor of the kdgRKAT and kduID operons for pectin utilization.
P50844
Q9AB94
SUCC_CAUVC
Succinyl-CoA synthetase subunit beta
Caulobacter
MNIHEHQAKAVLAEFGAPVPRGFAAFTPDEAAAAAEKLGGPVFVVKSQIHAGGRGKGKFEGLGPDAKGGVRVVKSVEEVRSNAEEMLGRVLVTHQTGPKGKQVNRLYIEEGAAIAKEFYLSLLVDRASSKVSVVASTEGGMDIEDVAHSTPEKIHTFTIDPATGVWPTHHRALAKALGLTGGLAKEAASLLNQLYTAFMAKDMAMLEINPLIVTADDHLRVLDAKLSFDGNSLFRHPDIKALRDESEEDPKEIEASKYDLAYIALDGEIGCMVNGAGLAMATMDIIKLYGAEPANFLDVGGGASKEKVTAAFKIITADPA...
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinat...
Q9AB94
B4SRZ0
ISPG_STRM5
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Stenotrophomonas maltophilia group
MHDAVTRPTPPSDATSWPRRQTHAVQIGGVTVGGGKPVVVQSMTNTDTSDVASSVKQVAELWRAGSEMVRLTVNTVEAAAAIPRIVDKLAMMGIDVPLIGDFHYNGHQLLTAEPACAEALAKYRINPGNVGFGKKKDLQFAQLIEFAIRYNKPVRIGANWGSLDQALAAKLMDENNHREQPWDAGRVLREALIRSALDSAEQAVEIGLPRDRIVLSAKVSGVQELIAVYRDLAQRSDFALHLGLTEAGIGSKGIVASSAALSVLLQEGIGDTIRISLTPEPGQSRTQEVIVAQELLQTTGQRAFTPLVTACPGCGRTTSE...
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
B4SRZ0
Q6GBQ6
UNG_STAAS
Uracil-DNA glycosylase
Staphylococcus
MEWSQIFHDITTKHDFKAMHDFLEKEYSTAIVYPDRENIYQAFDLTPFENIKVVILGQDPYHGPNQAHGLAFSVQPNAKFPPSLRNMYKELADDIGCVRQTPHLQDWAREGVLLLNTVLTVRQGEANSHRDIGWETFTDEIIKAVSDYKEHVVFILWGKPAQQKIKLIDTSKHCIIKSVHPSPLSAYRGFFGSKPYSKANAYLESVGKLPINWCESEA
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
Q6GBQ6
P49763
PLGF_HUMAN
Placenta growth factor
Homo
MPVMRLFPCFLQLLAGLALPAVPPQQWALSAGNGSSEVEVVPFQEVWGRSYCRALERLVDVVSEYPSEVEHMFSPSCVSLLRCTGCCGDENLHCVPVETANVTMQLLKIRSGDRPSYVELTFSQHVRCECRHSPGRQSPDMPGDFRADAPSFLPPRRSLPMLFRMEWGCALTGSQSAVWPSSPVPEEIPRMHPGRNGKKQQRKPLREKMKPERCGDAVPRR
Growth factor active in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. It binds to the receptor FLT1/VEGFR-1. Isoform PlGF-2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.
P49763
A5UAH6
RUVC_HAEIE
Holliday junction resolvase RuvC
Haemophilus
MSIILGIDPGSRVTGYGVIRQTGRHLEYLGSGAIRTQVEDLPTRLKRIYAGVTEIITQFQPDMFAIEQVFMAKNADSALKLGQARGTAIVAAVNHDLPVFEYAARLVKQTVVGIGSADKVQVQEMVTRILKLSDKPQTDAADALAIAITHAHSIQHSLHIANSVKMTETQEKMTALLKTRYSRGRFRLKI
Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.
A5UAH6
B6IZ52
NUOH_COXB2
NDH-1 subunit H
Coxiella
MTDQLITLIWIIIKIVLILVPLLVAVAFITLAERKVIGYMQSRVGPNRVGFRGLAQPIADIFKLLLKEVIIPTASSRYLYLIAPILSLVPALAAWAVIPFAQGWMLANVNAGLLFLFAMTSLGVYGILVAGWASNSKYAFFGALRSAAQVVSYEIPMGFALVGVLLAAGTMNLQGIVLRQSGGLWHWFWLPLLPLFVTYWITAVAETNRAPFDVAEGESEIVAGFHVEYAGVTFALFFLAEYANMVLVSAIATVIFLGGWLSPFQGIPGLESLFAWVPGIVWFVLKLSLFIFTYFWMRATFPRYRYDQIMRLCWKVLIPV...
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t...
B6IZ52
O35930
GP1BA_MOUSE
Glycocalicin
Mus
MALLILLFLLPSPLHSQHTCSISKVTSLLEVNCENKKLTALPADLPADTGILHLGENQLGTFSTASLVHFTHLTYLYLDRCELTSLQTNGKLIKLENLDLSHNNLKSLPSLGWALPALTTLDVSFNKLGSLSPGVLDGLSQLQELYLQNNDLKSLPPGLLLPTTKLKKLNLANNKLRELPSGLLDGLEDLDTLYLQRNWLRTIPKGFFGTLLLPFVFLHANSWYCDCEILYFRHWLQENANNVYLWKQGVDVKDTTPNVASVRCANLDNAPVYSYPGKGCPTSSGDTDYDDYDDIPDVPATRTEVKFSTNTKVHTTHWSL...
GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
O35930
Q1MAZ2
ATPB_RHIL3
F-ATPase subunit beta
Rhizobium
MAEAATPKIGSVGRVTQVIGAVVDVAFEGELPKILNALETSNNGNRLVLEVAQHLGENVVRTIAMDSSEGLVRGQEVADTGAPIMVPVGNETLGRIMNVIGEPVDEAGPLVTAHKRAIHQDAPSYVEQSTESQILVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESNVNKHGGGEGSKAALVYGQMNEPPGARARVALTGLTVAEHFRDQGQDVLFFVDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGQMQERITTTTTGSITSVQAIYVPADDLT...
Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.
Q1MAZ2
Q8R2Z0
ADIPL_MOUSE
Adipolin gCTRP12
Mus
MWAWGWAAAALLWLQTAGAGARQELKKSRQLFARVDSPNITTSNREGFPGSVKPPEASGPELSDAHMTWLNFVRRPDDGSSRKRCRGRDKKSRGLSGLPGPPGPPGPPGPPGSPGVGVTPEALLQEFQEILKEATELRFSGLPDTLLPQEPSQRLVVEAFYCRLKGPVLVDKKTLVELQGFQAPTTQGAFLRGSGLSLSLGRFTAPVSAIFQFSASLHVDHSELQGRGRLRTRDMVRVLICIESLCHRHTSLEAVSGLESNSRVFTVQVQGLLHLQSGQYVSVFVDNSSGAVLTIQNTSSFSGMLLGT
Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes .
Q8R2Z0
P13743
LDHB_ANAPL
Epsilon-crystallin
Anas
MATLKEKLMTPVAAASAVPSSKITVVGVGQVGMACAVSILGKGLCDELALVDVLEDKLKGEMMDLQHGSLFLQTHKIVADKDYAVTANSKIVVVTAGVRQQEGESRLNLVQRNVGVFKGIIPQIVKYSPNCTILVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDTARFRYLMAERLGIHPTSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPAMGTDKDSENWKEVHKQVVESAYEVIRLKGYTNWAIGLSVAELCETMLKNLCRVHSVSTLVKGTYGIENDVFLSLPCVLSASGLTSVINQKLKDDEVAQLKKSA...
Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).
P13743
A9WVP1
RSMG_RENSM
16S rRNA 7-methylguanosine methyltransferase
Renibacterium
MLEMTEAVASAAHSVFGDRLPLAQRYVEHLATSGIERGLIGPREVPRLWDRHVLNCAVVVELIEIDATVADVGSGAGLPGLCLALARPDLSITLIEPLERRVTWLSEVVADLGLSDQVTLFRMRAEQAVDEVNCSVVTARAVSALDKLAGLTIPLLHGNGQFLAVKGRSAAEEITKAAKAVRKLGGTRTDVLVAGSSVLEEPTTVVRILVGSAHR
Specifically methylates the N7 position of guanine in position 518 of 16S rRNA.
A9WVP1
B7L1N2
KDPC_METC4
Potassium-translocating ATPase C chain
Methylorubrum
MLNQLRPALVLLVALTAITGLAYPLAVTGVAGALFPAKAAGSLIERDGRIVGSSLIGQSFTGECYFHGRPSATTAADPADASKTVAAPYNAANSAGSNLGPTSAALAERVKGDLAALKAENPGRPVPVDLVTTSGSGLDPDVSPEAALFQVPRIARARNLPEDRLRDLVAGQLQGRTLGLLGEPRVNVLALNLVLVDLAKR
Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation...
B7L1N2
Q87MQ5
AQPZ_VIBPA
Aquaporin Z
Vibrio
MNKYLAEAFGTFWLVLGGCGSAVLAAGFPDVGIGLLGVALAFGLTVLTMAFAIGHISGCHLNPAVTVGLWAGGRFDTKDVAPYIIAQVIGGLIAGGILYVIATGQAGFDVVGSGFAANGYGEHSPGQYSMLAALVSEIVMTMMFLIVIMGATDKRAPQGFAPIAIGLCLTLIHLISIPVTNTSVNPARSTAVAMYVGDWAVSQLWLFWVAPIVGGVLGAVIYKNLLGKESND
Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity.
Q87MQ5
Q49ZG1
RL16_STAS1
50S ribosomal protein L16
Staphylococcus
MLLPKRVKYRRQHRPKTTGRSKGGNYVTFGEYGLQATTTSWITSRQIESARIAMTRFMKRGGKVWIKIFPHTPYTQKPLEVRMGAGKGAVEGWIAVAKPGRILFEIAGVNEEVAREALRLASHKLPVKTKFVKREELGGETNES
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
Q49ZG1
Q12P58
PDXB_SHEDO
Erythronate-4-phosphate dehydrogenase
Shewanella
MKIVADENMPFVEALFGGLGDVVRVNGRSLSAKDLKDADVLLVRSVTKVNQTLLQDCQSLKFVGSATIGTDHIDQAYLKHRGIPFANAPGCNATGVGEYAFIAALELAQREQVNLKDKVIGIVGAGNTGMAAAKCFAAFGNKVLVCDPFKTQDMLYFPLVGLDELIQQADIISLHVPLSDNGPYKTWYLFDEARLESLTPNTWLFNCCRGEVIDNRALIEFKRRRDDIKLVLDVWQGEPHPMAELVPLTEFATPHIAGYSLEGKARGTFMLYQALATSLNLPVKASLQSLLPSHFVNQLGLASQTELTQGQLLSLARLVY...
Catalyzes the oxidation of erythronate-4-phosphate to 3-hydroxy-2-oxo-4-phosphonooxybutanoate.
Q12P58
P0DQQ0
PA2B3_BOTBZ
Phosphatidylcholine 2-acylhydrolase
Bothrops
SLWEWGQMILKETGKNPFPYYGAYGCYCGWGGRRKPKDATDRCCFVHDCCRYKKLTGCPKTNDRYSYSRLDYTIVCGEDDPCKEICECDKAAAVCFRENLRTYNKKYMAHLRVLCKKDKPC
Snake venom phospholipase A2 (PLA2) that exhibits myotoxin and anticoagulant activity . Displays edema-inducing activities in mouse paw . Also displays cytotoxic activity against some cell lines and myotubes, and antimicrobial activities against E.coli, C.albicans and Leishmania . PLA2 catalyzes the calcium-dependent h...
P0DQQ0
Q8GSJ6
LQY1_ARATH
Protein LOW QUANTUM YIELD OF PHOTOSYSTEM II 1
Arabidopsis
MPVSAPSPPRLHSPFIHCPINFTPSSFSARNLRSPSTSYPRIKAELDPNTVVAISVGVASVALGIGIPVFYETQIDNAAKRENTQPCFPCNGTGAQKCRLCVGSGNVTVELGGGEKEVSNCINCDGAGSLTCTTCQGSGVQPRYLDRREFKDDD
Protein disulfide-isomerase probably involved upon formation of a complex with HHL1 in maintaining photosystem II (PSII) activity under high light by regulating repair and reassembly of PSII complexes.
Q8GSJ6
Q8PHQ3
SSUB2_XANAC
Aliphatic sulfonates import ATP-binding protein SsuB 2
Xanthomonas
MAGLASGATTACRATPMSAATTGLPLRVRGIAKRYGDSDVLRGIDLEIAPSACVAIVGRSGCGKSTLLRVIAGLETADVGTVDSGRAPLAAQRDAVRLMFQDARLLPWKRVIDNVALGLGRAGRAQAQQALDAVGLGTRGNAWPSALSGGQRQRVALARALVHRPRLLLLDEPLGALDALTRIEMQQLIVQLWRQHGFTLVLVTHDVAEASALADRIVVLEHGKVGLDVAVPVPHPRAPGLPALASIQAQVLSRLLGTTQVPEPAAPKAQTRHGPPRGATAQDTSPLQRIL
Part of the ABC transporter complex SsuABC involved in aliphatic sulfonates import. Responsible for energy coupling to the transport system.
Q8PHQ3
P0CE09
RPOB_CHLTR
Transcriptase subunit beta
Chlamydia
MFKCPERVSIKKKEDILDLPNLVEVQIKSYKQFLQIGKLAEERENIGLEEVFREIFPIKSYNEATILEYLSYNLGVPKYSPEECIRRGITYSVTLKVRFRLTDETGIKEEEVYMGTIPIMTDKGTFIINGAERVVVSQVHRSPGINFEQEKHSKGNVLFSFRIIPYRGSWLEAVFDINDLIYIHIDRKKRRRKILAMTFIRALGYSTDADIIEEFFSVEERSLRLEKDFVALVGKVLADNVVDADSSLVYGKAGEKLSTAMLKRILDAGVQSLKIAVGADENHPIIKMLAKDPTDSYEAALKDFYRRLRPGEPATLVNAR...
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
P0CE09
C0MA63
MURB_STRE4
UDP-N-acetylmuramate dehydrogenase
Streptococcus
MIAELEGIDIRENEALKHYTYTQVGGPADFLAFPRNHYELSRIVDYANHNHIPWMVLGNASNLIVRDGGIRGFVIMFDKLNAVRLNGYTLEAEAGANLIETTKVAKFHSLTGFEFACGIPGSIGGAVFMNAGAYGGEIAHIFLSAKVLTPEGKIKKISAREMAFGYRHSVIQETGDIVISAKFALKPGNHDSICQEMNRLNHLRKLKQPLEFPSCGSVFKRPPGHFAGQLIMDANLKGHRVGGVEVSKKHAGFMINVADGSAKDYEDLIAHVIRTVEQASGVRLEPEVRIIGESL
Cell wall formation.
C0MA63
Q9JJK5
HERP1_MOUSE
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
Mus
MEPEPQPEPVTLLVKSPNQRHRDLELSGDRSWSVSRLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLQDLLPKQEKRHVLHLVCNVKNPSKMPETSTKGAESTEQPDNSNQTQHPGDSSSDGLRQREVLRNLSPSGWENISRPEAVQQTFQGLGPGFSGYTTYGWLQLSWFQQIYARQYYMQYLAATAASGTFVPTPSAQEIPVVSTPAPAPIHNQFPAENQPANQNAAAQAVVNPGANQNLRMNAQGGPLVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRQRPVQNFPD...
Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway.
Q9JJK5
B0BSQ0
ARGB_ACTPJ
NAG kinase
Actinobacillus
MLQNEVENFTNLLEQATVYLAPYQEKIIVVKYGGNAMINEDLKKLVMQDILLLNQLGVKVVLVHGGGPEISQGVKLLGKEPQFINGLRVTDQDTINVVLQMLAGKVNKSLVALLKGKGVGLCGIDANMLQCEKLQAEVDYGFVGEIVKVNTQLLELALSANLIPVISTVGVDDQGVAYNINADTVASEIAMALGAAKLVSMTDIAGLLRDRFDESTLIPEVEVSEVQGLIDQGIIAGGMIPKIACCTDFINAGGIEANIIDGRVPHAILVSLFGGKNGTLFYKK
Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.
B0BSQ0
Q0BT53
RUVB_GRABC
Holliday junction ATP-dependent DNA helicase RuvB
Granulibacter
MPEHDPHQENRTVSSVRLEDDAAEASLRPQSLAEFIGQRASRENLSIFIQAAKARGEAMDHVLLHGPPGLGKTTLAQIVSRELGVGFRATSGPVIQRAGDLAAILTNLQPRDVLFIDEIHRLQPAIEEVLYPAMEDFQLDLIIGEGPAARSVRIDLAPFTLVAATTRAGLLATPLRDRFGIPLRLIFYTASELELIVSRGAEKLGFDLSREGAAEIARRSRGTPRIAGRLLRRVRDFAMVQGVSPVDRSTADAALQRLEVDSLGLDAMDRRYLHRIAVHHAGGPVGVETLAAALAEARDTLEDVIEPYLIQEGLILRTSR...
The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
Q0BT53
Q2S9Z0
MURD_HAHCH
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Hahella
MSILARDRNIAVIGLGKTGLSCADYLTRRGYGFCVMDTRENPSGLAELNAINPDVPVVTGKLDQDMLARAAEIWLSPGVPLSHPDLQAVKGQVKICGDVDVFSREANAPILAITGSNGKSTVTTLVGEMAKACGVNVAVGGNLGTPVLDLLADEVELYVVELSSFQLETTDRLGALAATVLNLSEDHMDRYADMMAYHLAKLRVFYGCRRQVLNRDDALAQPPLSREAEITWFTLKTPEPGQYGVLEEKDGAWLAYGAEKLLPVEQMRIRGKHNWSNALAALALADAAGLEREPCLQALREFTGLTHRCEWVADKDGVAY...
Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).
Q2S9Z0
A6ZRL6
SQS1_YEAS7
Squelch of splicing suppression protein 1
Saccharomyces
MAKRHSHYQGSRRRHARGSNSKKAGRGNAKGIQGRKIKKKPTPTNSWHNSSIPLGEGDLDDVGADFNPGRAFISPKTIEDYYFGRDAKSRSMKMGGLRPGNRYDSSTDLQAGRAAFRKRPMQFVKAKEVYDPSHNMIQKLRAKNETKNSEEIVEREADVFEEPGKMTSDVEYINNEDSENEDDDSQNSPSTDHSLSSNESKVEDGDLFFVDEEAQQSPDLTKIKRVCIEEIARPREVAIEFDPILTIGKVELSVSEGNESKEISVDVPNKGNKTYHPFAGYISNVLHGMHTSDSDNDELDYEIETENNSEPLYESSASSE...
May be involved in splicing since overexpression antagonizes the suppression of splicing defects by SPP382 mutants.
A6ZRL6
Q5P1A8
BPT_AROAE
Aspartate/glutamate leucyltransferase
Aromatoleum
MQKDYPYALIQFYATAPYTCSYLSDRVARSQVATPGHLIDTPVYSELVRNGFRRSGMFTYRPYCDHCRACVPVRIPVKRFEPDRSQRRAWKMHHELRANEQPLAYSEEHYALYQRYQGSRHAGGGMDQDNREQYAHFLLQSHVDTRLVEFREGDVLRMVSVIDRLSDGLSSVYTFYDPDQTHASYGTYGILWQIEVCRRLKLPYLYLGYWIKESRKMTYKVRFHPLEGRLRGEWRDIDPLRDRASE
Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate.
Q5P1A8
B5EBP8
MRAY_CITBB
UDP-MurNAc-pentapeptide phosphotransferase
Citrifermentans
MLYHLLYPLASDYKLFNVFKYLTFRSIYAMITALLLAFIVGPWVVRKLEALQARQVIRTDGPESHLKKQGTPTMGGVLILVCIVLPTLLWADLKNVFIWLTLLIIVGYGVLGFVDDYKKVVEKNPKGLSPRQKMFWQMLLAAGVGIFLFYLPGFSTELYLPFFKRVHPELGILFIPFVMLVIVGASNAVNLTDGLDGLAIGPVAINAATYLLFCYIAGNAKLSGYLQIPYVPGAGELAVLCGAMVGAGLGFLWYNSYPAEVFMGDVGSLSLGGALGTLAVLTKQEILLVIVGGVFVVEALSVIFQVGSYKYRGKRIFRMA...
Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I...
B5EBP8
Q7VQH5
ERPA_BLOFL
Iron-sulfur cluster insertion protein ErpA
Candidatus Blochmannia
MSNDKKNAFPIKLTHSAADQVKKLISSQDYAEKLDLKLRVYILGGGCGGFQYKFILDDQVSNDDCVIESNGAIVVVDPMSLQYLFGGIIDYYEGLEGSKFLVVNPNAKGVCSCGSSFNI
Required for insertion of 4Fe-4S clusters for at least IspG.
Q7VQH5
O32041
YRVJ_BACSU
Putative N-acetylmuramoyl-L-alanine amidase YrvJ
Bacillus
MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSGPGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSSDTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYVTSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNEKNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDASTSASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTS...
Probably involved in cell-wall metabolism.
O32041
B6EL06
RSMC_ALISL
rRNA (guanine-N(2)-)-methyltransferase RsmC
Aliivibrio
MSYSAPSQITQRQLAYFEGKHVLIAGELNDNFPLELDKHCASTSIFTTNYGYYKQFSENPKINCYFGTELIEESHADMILLYWPKAKAEAEYLLTMLLAKLGKDTEIIVVGENRSGVKSVEKMFANFGPMNKLDSARRCSFYWGQCTETAPSFNLQDWFKEYQVQFKEHTIEVRSLPGVFSHGEFDKGSELLLQTLPSLRGHVLDFGCGAGVLGSVMKTINPKIHLDMVDISAFAIASSIETLKANGLEGNVFASDVYSDTKQNYQFIVSNPPFHAGLKTHYSSTEELLQKAPQNLTHSGQMIFVANSFLQYPPIVEKVF...
Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle.
B6EL06
Q3IGS9
BIOD_PSET1
Dethiobiotin synthase
Pseudoalteromonas
MKEFFITGTDTDAGKTHVTSLLLKLLAQHKKQAIGFKPLASGCEMAFDQLVNADALILMESATVSAKYDIINPFAFAPAIAPHIAAEQAGVTITADKLSSAYKNVKQQGADYILTEGAGGWALPISNTDYLYNWVKAEQLPVILVVGMKLGCLNHALLTAAHMQSMGINCIGWIANQVDPNMDEYQANLDSLKLRLPFPILAISPYSEQTPKLQIYKTLLENFALNT
Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.
Q3IGS9
Q9GJX5
CP4AL_PIG
Cytochrome P450 4A21
Sus
MTVPALASVSGLLQVASLLGLLLLLLKAAQLYLRRQWLLKALQQFPSPPSHWLYGHSREFQEESELQPLLKRVEKYPSACARWLWGTRAMVLVYDPDYMKVVLARSEPKAPVLYRLLIPWIGCGLLLLNGQMWFQRRRMLTPAFHYDILKPYVGLMAKSVQVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSAQTDGDSQSYIQAIWDLKNLIFSRLRSAFLQNDIIYRLSPEGRQCQRACQKVHQHTDRVIQLRKTHLQKEGEMENVKKKRHLDFLDILLFARMENGNSLSDTDVRAEVDTFMAAGHDST...
Catalyzes the 6 alpha hydroxylation oxidation of taurodeoxycholate to produce the pig specific bile acid taurohyocholic acid.
Q9GJX5
A4VHM7
EFG_PSEU5
Elongation factor G
Pseudomonas
MARTTPINRYRNIGICAHVDAGKTTTTERILFYTGLSHKMGEVHDGAATTDWMVQEQERGITITSAAVTTFWQGSRGQYDNYRVNVIDTPGHVDFTIEVERSLRVLDGAVVVFCGTSGVEPQSETVWRQANKYGVPRIVYVNKMDRQGANFLRVVGQIKQRLGHTPVPVQLAIGSEENFAGQIDLIKMKAIYWNDDDKGTTYREEEIPAELMDLAEEYRSNMIEAAAEANEELMNKYLEGGELTIEEIKAGLRQRTIACEIVPAVCGSSFKNKGVPLVLDAVIDYLPAPTEIPPIQGVNPDNEEQVDERHASDDEPFSAL...
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respective...
A4VHM7
O97231
RL44_PLAF7
60S ribosomal protein L44
Plasmodium (Laverania)
MVNVPKTRKTYCSNKCKKHTMHKVSQYKKGKERLSSLGRRRYDMKQKGFGGQTKPVFKKKAKTTKKIVLKLECTKCKKKRFQTMKRCKTFEMGADKKKKGGAVY
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell . The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains...
O97231
Q5RFC1
CKLF6_PONAB
Chemokine-like factor superfamily member 6
Pongo
MENGAVYSPTTEEDPGPARGPRSGLAAYCFLGRLPLLRRVLKGLQLSLSLLAFICEEVVSQCTLCGGLYFFEFVSCSAFLLSLLILIVYCTPFYERVDTTKVKSSDFYITLGTGCVFLLASIIFVSTHDRTSAEIAAIVFGFIASFMFLLDFVTMLYEKRQESQLRKSENTTRAEALTEPLNA
Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal de...
Q5RFC1
Q5QD12
TAA7A_MOUSE
Trace amine-associated receptor 7a
Mus
MDKLVDHFLSDQSRTMNEDLFSATSTELCYENLNRSCVRSPYSPGPRLILYAVFGFGAALAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSTVRSVEGCWYFGESYCKFHSCFEGSFCYSSIFHLCFISVDRYIAVSDPLTYPTRFTASVSGKCITFSWLLSIIYSFSLLYTGANEAGLEDLVSVLTCVGGCQIAVNQSWVFINFLLFLIPTLVMMTVYSKIFLIAKQQAQNIEKMSKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFITPTYVYEILVWIAYYNSA...
Orphan olfactory receptor specific for trace amines.
Q5QD12
C5BPP8
COAX_TERTT
Pantothenic acid kinase
Teredinibacter
MKLLVDAGNSRIKWWVPECQAHGVVDRLALDDLAGEIAAVIDISKLSSVRVSCVAGKSIETQLRGELGFARDLDVKFARVSSPLPILTVAYREIHRLGVDRWLAMLAVREKFPDRFCAVLDAGSAVTVDFVTEAGVHEGGMIVPGVQTMARALWSNTSDVAVERLELVPRWCPGVDTYDCVRQGVSALYTGLVNEVHSYIDGSAERHLSPAIVVTGGDRHWFTQAFSSPVVVDPHLVLKGLLVLDELEK
Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.
C5BPP8
Q24MD8
RLMH_DESHY
rRNA (pseudouridine-N3-)-methyltransferase RlmH
Desulfitobacterium
MLQIKIVAVGKIRERFLMEGIKEYAKRLSAYIRLEMTEIADEPCPERLSAADEERVKDREGERLLKGIGPQEHVILLDLQGKEFTSPDFSEYMDDLALMGKSSVTFIIGGSLGVSGEVRKRADYRWSFSRLTFPHPLMRLMLLEQIYRAMRISKGEPYHK
Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.
Q24MD8
G2TRP6
COA6_SCHPO
Cytochrome c oxidase subunit 6B-like protein new16
Schizosaccharomyces
MAGNGALRRSAREKCWEARDAYFGCLDRHSILDGLKDDTKAAQACSAEKTAFETDCVKSWVNYFLKFRVQQHQQQEAIKKLEAQGAKKLN
Involved in cytochrome c oxidase complex assembly and is required for efficient formation of respiratory supercomplexes comprised of complexes III and IV.
G2TRP6
P65884
PURA_STAAM
IMP--aspartate ligase
Staphylococcus
MSSIVVVGTQWGDEGKGKITDFLAEQSDVIARFSGGNNAGHTIQFGGETYKLHLVPSGIFYKDKLAVIGNGVVVDPVALLKELDGLNERGIPTSNLRISNRAQVILPYHLAQDEYEERLRGDNKIGTTKKGIGPAYVDKVQRIGIRMADLLEKETFERLLKSNIEYKQAYFKGMFNETCPSFDDIFEEYYAAGQRLKEFVTDTSKILDDAFVADEKVLFEGAQGVMLDIDHGTYPFVTSSNPIAGNVTVGTGVGPTFVSKVIGVCKAYTSRVGDGPFPTELFDEDGHHIREVGREYGTTTGRPRRVGWFDSVVLRHSRRV...
Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
P65884
A6V9B1
FLGI_PSEA7
Basal body P-ring protein
Pseudomonas
MTKFKHLLALAALLLAAGAAQAERLKDIASIQGVRTNQLIGYGLVVGLSGSGDQTTQTPFTLQTFNNMLAQFGIKVPANVGNVQLKNVAAVSVHADLPPFAKPGQPIDVTVSSIGNAKSLRGGSLLMTPLKGIDGQVYAVAQGNLVVGGFDAEGRDGSKITVNVPSAGRIPAGATVERAVPSGFDQGNSLTLNLNRPDFTTAKRIVDRINELLGPGVAHAVDGGSVRVSAPLDPNQRVDYLSILENLDVQPGEAVAKVIINSRTGTIVIGQNVKVSPAAVTHGSLTVSITEDPIVSQPGAFSNGQTAVVPRSRVNAEEET...
Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.
A6V9B1
A2WYF4
STAD2_ORYSI
SSI2 homolog
Oryza sativa
MALRPNDVTLRLTPPLAAAARRNRRAAAGGVRVYAVASGAVSTKVENKKPFAPPREVHVQVTHSMPPQKIEIFKSLDDWARDNILSHLKPVEKCWQPQDFLPDPASDGFHDEVKELRERAKEIPDDYFVCLVGDMITEEALPTYQTMLNTLDGVRDETGASPTAWAVWTRAWTAEENRHGDLLNKYLYLTGRVDMRQIEKTIQYLIGSGMDPRTENNPYLGFIYTSFQERATFISHGNTARHAKDFGDLKLAQICGIIASDEKRHETAYTKIVEKLFEIDPDGTVLAFADMMKKKISMPAHLMFDGEDDKLFEHFSMVAQ...
Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons 9 and 10 of the acyl chain. Required for the repression of the salicylic acid (SA) signaling pathway.
A2WYF4
B6Q702
UTP25_TALMQ
U three protein 25
Talaromyces sect. Talaromyces
MPPPRKRGRGSFRGSSRGAHRGRGHARGGRNSFQTSRVDEKREIESSDDEEQFNGFEDEVSGGEEPMQDVEIASEPSSEDEEPATERSYNSLLQLLNAKSEPSHARKRRKLDHLESKQDKPNREVEIQETTKEPEEQDVLENQEASEEEDNVEVDRAGESDDEDEEDASDPFETHISSPDETEISKRVKEITAGKWRSIKSSLLETFRLIYNIPDEEGGSWSIPSAVKNTRSLKLKKRLIPTAAERIPSFSGISQNIASLVFNYSDVLFGDRKASNAAQLRDLLSLHALNHVLKTRDRVIKNNARLSRDINPDIELRDQG...
DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.
B6Q702
Q6ZC03
ORR33_ORYSJ
OsRRA19
Oryza sativa
MDQARISFFPDGLRVMIIDDDAKAVRRATATLSQLQYAVVATHSTASAGLRALSGDNVVEIQAILCDVHKVVSSGFDFRRVVESELRIPVIYLLSKMEEEDMVAGEDAEFLNHLLLTATYIVRKPLNPTVMARLWRVVAWRMYCLEERIQANVAANAGAGGEDDDDDDDVVIVEEPQVHFKVVRRTSGGSRKRQLTINVVDDGNRGSGSGGGGGGGADANPTRILQHITSNLQEFRTKHQKKDMAIERPLISSDSMFLKAILPTLKISPCNPLTLTGGIGSSSVAAEAFAGGSSSAAPLQIPVFQQQSTGNGNTVISFSN...
Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. May directly activate some type-A response regulators in response to cytokinins.
Q6ZC03
Q21QP7
RS11_ALBFT
30S ribosomal protein S11
Rhodoferax
MAKAPASNAAQRVRKKVRKNVADGIAHVHASFNNTIITITDRQGNALSWASSGGQGFKGSRKSTPFAAQVASEVAGRAAIEQGVKNLDVEIKGPGPGRESSVRALAALGIRINMIADVTPVPHNGCRPQKRRRI
Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.
Q21QP7
Q9ZLN3
BIOF_HELPJ
Alpha-oxoamine synthase
Helicobacter
MFSKSLEALHHVKRYRKRELFDPLLKDYASNDYLGLSVKKDLLQNAFDKLQSFDCHSPKASMLVNGYHPLHAELEERLADLLEFESALLVGSGFLGNLALIDTLLVKNALLFMDAHYHASGIFSTKIKPNQVIFFSHNDIKDLKQKLFNAPKNKLKFIAIEGVYSMDASIAPYDFYEIIQETPNAFLIVDEAHSFGTIGENLLGFLEYHRIKEKDKIIKLSTFSKALASYGACVLAPLQVIEFLTNRAKSVIYTTALSLLDTALTLAHLEYFIAQKQELKNELSKHQQIIFETLGVRTPTGFFTLEFENNPALLNAQYFL...
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
Q9ZLN3
Q2YA24
NUOD_NITMU
NDH-1 subunit D
Nitrosospira
MAEIRNYTMNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEYKTYIQSVPYMDRLDYVSMMANEHAYVMAIEKLLQLEVPIRAQYIRVMFDEITRILNHLLWLGAHALDVGAMTVFLYAFRDREDLMDAYESVSGARMHAAYYRPGGVYRDLPDSMPQYKASKIHDEKTTKARNENRQGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVGIGTVSPERAMALGFTGPMLRGSGVEWDLRKKQPYEVYDQLDFDIPVGVNGDCYDRYLVRIEEFRQSNRIIRQCVDWLRKNPGPVITDNHKVAPP...
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t...
Q2YA24
A4IP64
ADH1_GEOTN
Glycerol dehydrogenase
Geobacillus
MSVARIVFPPLSHVGWGALDQLVPEVKRLGAKHILVITDPMLVKIGLVDQVTSPLRQEGYSVHVYTDVVPEPPLETGEKAVAFARDGKFDLVIGVGGGSALDLAKLAAVLAVHDGSVADYLNLTGTRTLEKKGLPKILIPTTSGTGSEVTNISVLSLETTKDVVTHDYLLADVAIVDPQLTVSVPPRVTAATGIDALTHAVEAYVSVNASPTSDGLAVAAIRLISRSLRKAVANGSDKQARIDMANGSYLAGLAFFNAGVAGVHALAYPLGGQFHIAHGESNAVLLPYVMGYIRQSCTKRMADIFNALGGNSSFLSEVEA...
Long-chain alkyl alcohol dehydrogenase that can oxidize a broad range of alkyl alcohols from ethanol to 1-triacontanol (C2 to C30) as well as 1,3-propanediol and acetaldehyde. The best substrate is ethanol. Also oxidizes glycerol.
A4IP64
Q9RT23
FABH1_DEIRA
3-oxoacyl-[acyl-carrier-protein] synthase III 1
Deinococcus
MKSIGITAIGMYVPERVVHNHEFESRMGIEDGWIESRSGIRERRFSAPGEFASHIGAKAVQDMLARDPDALKDVDLVIYATCTPDAMFPSTAALVAGQVGLTGVGAYDLSTACSGFVYALSMARGMILGGSAKNVLVLGGEVLSKALDQDDRDTAILFGDGCGCAVVGEVPAGYGFQDFVLGADSAGGPALYISNLADQFPDGQIMRGVPTMNGREVFKFAVRVLGDSGTQALQKSGLSNADVDWLIPHQANIRIIEAATQRFGIPMEKTVINLDRYGNTSAGTVPLALYEAVNDGRIQGGQQLLMVVFGGGLSWAACTM...
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-A...
Q9RT23
A5CXN7
EFG_VESOH
Elongation factor G
Candidatus Vesicomyosocius
MARTTPLDRYRNVGIMAHIDAGKTTTTERILLYTGRTHRIGEVHDGSATMDWMEQEQERGITITSAATTCFWKGMDGQFEDHRVNIIDTPGHVDFTIEVERSLKVLDSACAVFCAVGGVEPQSETVWRQANKYNVPRIGFVNKMDRSGADFLRVCKQIKTRLGGNPVPMQIAIGAEESFEGVIDLISMKAIFWNEVDQGATYETRDIPIELQGLAKEQYEFMVESAAEANDELMEKYLEESKLSNHDIKKGIRLRAIKSEIIPMFCGSAFKNKGVQAVLDAMIMYMPSPLDVDAITGISDDKDETVVPRKADDNEPFAAL...
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respective...
A5CXN7
Q8JH64
BTK_CHICK
Bruton tyrosine kinase
Gallus
MASIILESIFLKRSQQKKKTSPLNFKKRLFLLTESKLSYYEYDFERGRRGSKKGSVDIEKITCVETVVPENNPPPERQVPKKGEDYNMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKSVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCKILESRNGSLKAGRSHRKTKKPLPPTPEEDTMVMKPLPPEPAPSAAGEMKKVVALYNYVPMNVQDLQLQKGEDYLILEESHLPWWKARDKNGREGYIPSNYVTATSNSLEIYEWYSKNITRSQAEQLLKQEGKEGGFIVRDSTSKTGKYTVSVYAK...
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites...
Q8JH64
Q9JJS0
SCUB2_MOUSE
Scube/You
Mus
MGVAGCGRPREARALLLLLLLLPPLLAAAVPPDRGLTNGPSEDVDECAQGLDDCHADALCQNTPTSYKCSCKPGYQGEGRQCEDMDECDNTLNGGCVHDCLNIPGNYRCTCFDGFMLAHDGHNCLDMDECLENNGGCQHICTNVIGSYECRCKEGFFLSDNQHTCIHRSEEGLSCMNKDHGCGHICKEAPRGSVACECRPGFELAKNQKDCILTCNHGNGGCQHSCEDTAEGPECSCHPRYRLHADGRSCLEQEGTVLEGTESNATSVADGDKRVKRRLLMETCAVNNGGCDRTCKDTSTGVHCSCPTGFTLQVDGKTCK...
Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane . Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell s...
Q9JJS0
B6IQS5
ATPF1_RHOCS
F-type ATPase subunit b 1
Rhodospirillum
MAIDGWTVALQAVNFLILVLLLRHFLYRPVLAMIDRRKAEATRLLDDAALRVEAAKAERQKAETLRADLEAQADALLADSRARAGKELEELRTRARREADGILAEGRKALAEERRAAEADLRGKAAGLAVEIAGRLLAAATPGARVEPFLDRVCTRLTALPEPERQVLAGQAADGGIRIVTAVPLDEAGRAHCRDRAHTLLGPDIALTFADDPELLAGVELHFAHTVIRDSWRDLLGRIGLELDGHDDAHRIA
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
B6IQS5
O69556
MURF_MYCLE
UDP-MurNAc-pentapeptide synthetase
Mycobacterium
MIDLTVARVTEIVGGALVDISPEEAAERRVTGSVEFDSRAVGPGGLFLALPGARSDGHDHAASAIAAGAVAVLAARPVGVPAIVVAPDPRTGDGGLTGVLEHDADGSGAAVLAALAKLAKAVAAELVAGGLTIIGITGSSGKTSTKDLVAVVLELLGEVVAPPESFNNELGHPWTVLRATRSTDYLILEMSARRPGNIAALAAIAPPKIGVVLNVGTAHLGEFGSREAIARTKTELPQAIMQSGVVILNVDDPAVAAMADATVARVIRVSRGSYSHPGSPNSPDVWTGPVSLDELARPRFTLHTRDPRAGATEIQLGVYG...
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
O69556
B9FJ61
SIP2_ORYSJ
Intramembrane protease 2
Oryza sativa
MKTHERAANLALAGLSLAPLVVKVNPNANVILTACLAVYVGCYRSVKPTPPAETMSKEHAMRFPLVGSAMLLSLFLLFKFLSKDLVNTVLTAYFFILGIAALCATLLPSIKRFLPKEWNDNAIVWRAPLFHSLSVEFTRSQVVASIPGFFFCIWYAAKKHWLANNVLGISFCIQGIEMLSLGSFKTGAILLSGLFFYDIFWVFFTPVMVSVAKSFDAPIKLLFPTGDAARPFSMLGLGDIVIPGIFVALALRFDVSRGIKNRYFNSAFLGYTVGLTVTIIVMNWFQAAQPALLYIVPGVIGFVAVHCLWNGEVKPLLEYN...
Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cyt...
B9FJ61
P46063
RECQ1_HUMAN
RecQ protein-like 1
Homo
MASVSALTEELDSITSELHAVEIQIQELTERQQELIQKKKVLTKKIKQCLEDSDAGASNEYDSSPAAWNKEDFPWSGKVKDILQNVFKLEKFRPLQLETINVTMAGKEVFLVMPTGGGKSLCYQLPALCSDGFTLVICPLISLMEDQLMVLKQLGISATMLNASSSKEHVKWVHAEMVNKNSELKLIYVTPEKIAKSKMFMSRLEKAYEARRFTRIAVDEVHCCSQWGHDFRPDYKALGILKRQFPNASLIGLTATATNHVLTDAQKILCIEKCFTFTASFNRPNLYYEVRQKPSNTEDFIEDIVKLINGRYKGQSGIIY...
DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction.
P46063
Q26264
SM41_HEMPU
HSM41
Hemicentrotus
MKGVLFIVASLVAFATGQDCPAYYVRSQSGQSCYRYFNMRVPYRMASEFCEMVTPCGNGPAKMGALASVSSPQENMEIYQLVAGFSQDNQMENEVWLGWNSMSPFFWEDGTPAYPNGFAAFSSSGMAPPRPGAPPSRAWPVNPQNPMSGPPGRAPVMKRQNPPVRPGQGGRQIPQGVGPQWEAVEVTAMRAFVCEVPAGRNVPIGQQPGMGQGFGNQQPGFGNQPGMGGRQPGFGNQPGMGGRQPGFGNQPGMGGRQPGFGNQPGVGGRQPGFGNQPGMGGRQPGFGNQPGVGGRQPGFGNQPGMGGQQPGVGGRQPGFG...
Major matrix protein of the sea urchin embryo spicule which directs crystal growth in certain orientations and inhibit growth in others.
Q26264
Q0P8H8
C1436_CAMJE
PLP-dependent decarboxylase Cj1436
Campylobacter
MLIKLNDYEKNITQKIKDLKNASGSHSPSIFTMAEQIPELNIKIDSCFLSNPYATALFLRYLKEELIDGQKLRSVLEFYPSQNSIIAKTVADFIGIDPKNVFIGNGAIEIIQAVMHNFVGKKIIVNIPTFSSYYEFAKSETNVVYYQLSKEDNYNLNIEHYLNFVKNENPDSVVLINPNNPDGGYINYEKLRYILSELKYVKNIIIDESFIHFAYENKDYNGINIEYLFKEFHNTIIIKSMSKDFGVAGIRIGYAIMSEDKIRGLLKNGYLWNSSGLSEYFLRLYVRKNFFDEYDKVRREYIQETQTFFRKLSGIKQFKV...
Pyridoxal phosphate (PLP)-dependent decarboxylase involved in the biosynthesis of amidated D-glucuronic acid structures found on the capsular polysaccharide (CPS) of C.jejuni. Catalyzes the decarboxylation of L-serine phosphate to ethanolamine phosphate. Less active with L-threonine phosphate. No activity with L-serine...
Q0P8H8
Q0BTM1
SYV_GRABC
Valyl-tRNA synthetase
Granulibacter
MYERAMLSKNFDHAANEQRIYAGWEHGGAFAANPASSATPFTIMIPPPNVTGSLHMGHALTFTLQDSLVRWRRMQGRDVLWQPGTDHAGIATQMVVERLLASEGSPGRREIGRDAFLDRVWRWKAESGGNITHQLRRLGASLDWGRERFTMDEGLSAAVRDVFVTLYRQGLIYRDRRLVNWDPQLQTAISDLEVESREVRGNLWHIRYPLEDGEGSIIVATTRPETMLGDSAVAVHPEDERYTALIGKCVILPLTGRRIPIVADTYSDPEKGTGAVKITPAHDFNDFAVGRRHDLPMPSIMDREGRITLAEITCTEATDI...
Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.
Q0BTM1
Q9H0R5
GBP3_HUMAN
Guanine nucleotide-binding protein 3
Homo
MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAVLLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTLRDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPIHRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYINAISRGDLPCMENAVLALAQI...
Exhibits antiviral activity against influenza virus.
Q9H0R5
Q9TI97
MATK_SPOIN
Intron maturase
Sporobolus
MEKLERYSEKRKSRQQYFVYPLLFQEYIYAFAHDYALKGFEPVEIVGYNNKKFSSLLVKRLIIRMYQQNFWINSVNHPNQDRLLDHSNHFYSKFYSQILSEGFAIVLEIPFSLGELSCPGEKEIPKFQNLQSIHSIFPFLEEKFLHLHYLSHIEIPYPIHFEILVQLLEYRIQDVPSLHLLRFFLNYYSNWNSLITSMKSIFLLKKENKRLFRFLYNSYVSEYEFFLLFLRKQSSSLRLISSGTFLERIHFSMKMEHFGVMYPRFFQKTLWFFMDPLMHYVRYQGKAILASKGTLLLKKKWKSYLVNFSQYFLSFWTQPQ...
Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Q9TI97
P0C928
RTEL1_DANRE
Regulator of telomere elongation helicase 1
Danio
MPVIKLKGINVDFPFTPYPCQEDYMSKVIECLQKKVNGVLESPTGTGKTLCLLCSTLAWRDHFKDTISARKITERMGGAELFADRPMSSWGTAATDGDTPTYYTDIPKIIYASRTHSQLTQVVNELKNTSYRPKICVLGSREQLCINQEVMRHESNHIKVHMCRAKVSSRSCIFYNNVDEKSTDKEIVNSILDVEDLVKTGKKQRVCPYYLSRSLKQHADVIFMPYNYLLDPKSRRAHNIELKGAVVIFDEAHNVEKMCEESTSFDLTPHDLISAIEAVDRLLREQASDISKADSAEDFNVESLNSGLKMDITTIAKVKQ...
ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion...
P0C928