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2.75k
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5.51k
AlphaFoldDB
stringlengths
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10
Q5X9P6
PRSA2_STRP6
Foldase protein PrsA 2
Streptococcus
MKQMNKLITGVVTLATVVTLSACQSSHNNTKLVSMKGDTITVSDFYNETKNTELAQKAMLSLVISRVFETQYANKVSDKEVEKAYKQTADQYGTSFKTVLAQSGLTPETYKKQIRLTKLVEYAVKEQAKNETISKKDYRQAYDAYTPTMTAEIMQFEKEEDAKAALEAVKAEGADFAAIAKEKTIAADKKTTYTFDSGETTLPAEVVRAASGLKEGNRSEIITALDPAISKRTYHIIKVTKKATKKADWKAYQKRLKDIIVTGKLKDPDFQNKVIAKALDKANVKIKDKAFANILAQFAKPNQKQPAQK
Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins.
Q5X9P6
B8E7R0
DXR_SHEB2
2-C-methyl-D-erythritol 4-phosphate synthase
Shewanella
MQNMVILGATGSIGASTLSVISANPLAYSVYGLVANASVDKMLALCVAHKPKVAHMVDEAAAKQLRAVLPATLNIQVTTGMNDLLGLVTAAEVDTVMAAIVGAAGLVPTLEAVKAGKRVLLANKEALVMSGELFIEATKRSGAVLLPVDSEHNAIFQCLPQEVQANLGRCDLAASGISHILLTGSGGPFLRSDLATLAAMTPAQACKHPNWSMGPKISVDSATMMNKGLEFIEARWLFNTQAEQLKVVIHPQSVIHSMVQYRDGSVIAQMGNPDMRTPIAHCMAYPQRIHSGVEPLDFFKVGQLSFYEPDFERFPCLALAMDACAQGQEATTVLNAANEIAVEAFLQGQIGFTQIAKVNEACLVTVPKRPMGSIEDILALDAQTRVYARETLASIA
Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).
B8E7R0
B9M594
TRMD_GEODF
tRNA [GM37] methyltransferase
Geotalea
MKFDVLTLFPGMFEGPLTESILKRAREKGLIDVALHNIRDFAFDRHSVTDDYPYGGGAGMVMKVEPLAACVEHAQAGSPEARVILTTPHGRPFSHAVAAELAREEALIIICGRYEGVDERVRELFVDDEISLGDFVLTGGEMAAMVIIDAVSRLVPGVLGSEESAINDSFADGLLEYPQYTRPSEFRGLEVPKVLLSGNHQEIEMWRRHKSLEATALLRPDLLQSAKLTNGDRKYLEKSSKDAR
Specifically methylates guanosine-37 in various tRNAs.
B9M594
P24385
CCND1_HUMAN
PRAD1 oncogene
Homo
MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition . Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase . Hypophosphorylates RB1 in early G(1) phase . Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals . Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity . Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex . Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner .
P24385
Q9Z8H0
ISPG_CHLPN
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
Chlamydia
MTLITPAINSSRRKTHTVRIGNLYIGSDHSIKTQSMTTTLTTDIDSTVEQIYALAEHNCDIVRVTVQGIKEAQACEKIKERLIALGLNIPLVADIHFFPQAAMLVADFADKVRINPGNYIDKRNMFKGTKIYTEASYAQSLLRLEEKFAPLVEKCKRLGKAMRIGVNHGSLSERIMQKYGDTIEGMVASAIEYIAVCEKLNYRDVVFSMKSSNPKIMVTAYRQLAKDLDARGWLYPLHLGVTEAGMGVDGIIKSAVGIGTLLAEGLGDTIRCSLTGCPTTEIPVCDSLLRHTKIYLDLPEKKNPFSLQHSENFVSAAEKPAKTTLWGDVYGVFLKLYPHHLTDFTPEELLEHLGVNPVTKEKAFTTPEGVVVPPELKDAPITDVLREHFLVFHHHQVPCLYEHNEEIWDSPAVHQAPFVHFHASDPFIHTSRDFFEKQGHQGKPTKLVFSRDFDNKEEAAISIATEFGALLLDGLGEAVVLDLPNLPLQDVLKIAFGTLQNAGVRLVKTEYISCPMCGRTLFDLEEVTTRIRKRTQHLPGLKIAIMGCIVNGPGEMADADFGFVGSKTGMIDLYVKHTCVKAHIPMEDAEEELIRLLQEHGVWKDPEETKLTV
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Q9Z8H0
C0MBK6
OTC_STRE4
Ornithine carbamoyltransferase
Streptococcus
MTQVFQGRSFLAEKDFTREEFEYLIDFAAHLKDLKKRGIPHHYLEGKNIALLFEKTSTRTRAAFTTAAIDLGAHPEYLGANDIQLGKKESTEDTAKVLGRMFDGIEFRGFSQRMVEELAEFSGVPVWNGLTDEWHPTQMLADYLTVKENFGKLEGLTLVYCGDGRNNVANSLLVAGTLLGVNVHIFSPKELFPAEDIVKLAEGYAKASGAHVLVTDNADEAVKGADVLYTDVWVSMGEEDKFEERVKLLKPYQVNMELVKKAANDNLIFLHCLPAFHDTNTVYGKDVAEKFGVEEMEVTDEVFRSKYARHFDQAENRMHTIKAVMAATLGNLFIPKV
Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.
C0MBK6
P07678
ATPE_BACP3
F-ATPase epsilon subunit
Bacillus
MKTIHVSVVTPDGPVYEDDVEMVSVKAKSGELGILPGHIPLVAPLEISAARLKKGGKTQYIAVSGGFLEVRPDNVTILAQAAERAEDIDVLRAKARKSGRTPLQSQQDDIDFKRAELALKRAMNRLSVAEMK
Produces ATP from ADP in the presence of a proton gradient across the membrane.
P07678
Q9U6Y7
GFPL_DISST
GFP-like fluorescent chromoprotein dsFP483
Discosoma
MSCSKSVIKEEMLIDLHLEGTFNGHYFEIKGKGKGQPNEGTNTVTLEVTKGGPLPFGWHILCPQFQYGNKAFVHHPDNIHDYLKLSFPEGYTWERSMHFEDGGLCCITNDISLTGNCFYYDIKFTGLNFPPNGPVVQKKTTGWEPSTERLYPRDGVLIGDIHHALTVEGGGHYACDIKTVYRAKKAALKMPGYHYVDTKLVIWNNDKEFMKVEEHEIAVARHHPFYEPKKDK
Pigment protein that is green in color.
Q9U6Y7
A0A0H3KB22
QUEE_BURM1
Queuosine biosynthesis protein QueE
Burkholderia cepacia complex
MTYAVKEIFYTLQGEGANAGRPAVFCRFAGCNLWSGREEDRAQAVCRFCDTDFVGTDGENGGKFKDADALVATIAGLWPAGEAHRFVVCTGGEPMLQLDQPLVDALHAAGFGIAIETNGSLPVLESIDWICVSPKADAPLVVTKGNELKVVIPQDNQRLADYAKLDFEYFLVQPMDGPSRDLNTKLAIDWCKRHPQWRLSMQTHKYLNIP
Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
A0A0H3KB22
A8LC67
RL1_FRASN
50S ribosomal protein L1
unclassified Frankia
MKRSKAYRAAAEKIDATALYSPLDAARLARETSSTKYDATVEVAIRLGVDPRKADQMVRGTVNLPHGTGKSPRVAVFAAGEKAAEATAAGADVVGSDDLVARIQEGFLDFDATVATPDQMAKVGRIARILGPRGLMPNPKTGTVTLDVAKVVGDIKGGKINFRVDKQGNLHIVIGKVSFSEAQLIENYTVALDEIVRVKPSAAKGRYLKKVTFATTMGPGIPVDPNRTRNLLEDAPA
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
A8LC67
H6LGM8
CARE_ACEWD
Electron transfer flavoprotein subunit alpha
Acetobacterium
MAIKVIEEKCIGCSKCQKSCPFDAITIENKIAVIGDACTNCGTCIDVCPTEAILQEGTEKIVRDLSMYKGVWVFAEQREGKIMPVVFELLGEGKKLANEIGTELCAILCGSNVAELTDELFAYGADKVYLADAPELEKYTTDGYSKIINEAIGLYKPEIVLYGATHIGRDLAPCLAVKVNTGLTADCTKLEIDPDDKKIRQTRPAFGGNLMATIVCPGSRPQMSTVRPGVMDKAAYDPSQKGEVIKLDATFNEGDIRTKVLEIVKTTTDNISISDADFIVSGGMGLGKPEGFELLKQLADKLGGTVATSRACVDAGWADHAQQVGQTGTTVKPQIYFACGISGAIQHIAGMQDSDIIIAINKNENAPIFEVADYGIVGDLYKVIPAIIEELDKIGK
Caffeyl-CoA reductase-Etf complex catalyzes the reduction of caffeyl-CoA to yield hydrocaffeyl-CoA. It couples the endergonic ferredoxin reduction with NADH as reductant to the exergonic reduction of caffeoyl-CoA with the same reductant. It uses the mechanism of electron bifurcation to overcome the steep energy barrier in ferredoxin reduction. The electron transfer flavoprotein (Etf) mediates the electron transfer between the different donors and acceptors. The iron-sulfur cluster may be involved in electron transport, possibly in the intramolecular electron transfer from the Etf protein subunit to the caffeyl-CoA reductase subunit inside the complex. The complex can also reduce 4-coumaroyl-CoA and feruloyl-CoA.
H6LGM8
A4QK75
NU1C_ARAHI
NADH-plastoquinone oxidoreductase subunit 1
Arabis
MIIYATEVETINSFVRLESLKELYSLVWIFVPIFSLVLGIITGVLVIAWIERELSAGIQQRIGPEYAGPLGILQALADGTKLLFKEDLRPSRGNTPLFSIGPSIAVISILLSYSVIPFSNHLVLADLNIGIFLWIAISSIAPIGLLMSGYGSNNKYSFLGGLRAAAQSISYEIPLTLCVLSISLLSNSLSTVDIVEAQSKYGFWGWNLWRQPIGFIIFLISSLAECERLPFDLPEAEEELIAGYQTEYSGIKFGLFYVASYINLLISSLFVTILYLGGWNISIPYISIPYISILELFERDPIFGTTIGIFITLAKTYLFLFISIATRWTLPRLRMDQLLNLGWKFLLPISLGNLLLTTSFQLFSL
NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.
A4QK75
P14319
QACC_STAAU
Quaternary ammonium determinant C
Staphylococcus
MPYIYLIIAISTEVIGSAFLKSSEGFSKFIPSLGTIISFGICFYFLSKTMQHLPLNITYATWAGLGLVLTTVVSIIIFKEQINLITIVSIVLIIVGVVSLNIFGTSH
Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds and ethidium bromide.
P14319
B0BWA7
RL10_RICRO
50S ribosomal protein L10
spotted fever group
MLRSEKPVAVEDIVNIYKESPSIIITHYHGLTVSQVSVLREALKSKEAGFKVVKNTLAKIAANQTGLNSIANLFAGPTAIVYSKEPVEMAKLVVNFAKANDNLKIIGGIVDNHVLDEHSIKELSKLLTLNELRGKIIGLLQAPATQVVGVLQAPSSSMARVIQAYASKN
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
B0BWA7
Q6DE23
KISHB_XENLA
Transmembrane protein 167B
Xenopus
MTNVYSLDGLLVFALLFVCTCAYFRKVPRLRSWLLSEKKGVWGVFYKAAVIGSRLHLAVSISCIAMAFYVLFIK
Involved in the early part of the secretory pathway.
Q6DE23
Q8KP10
ACT_BACMT
MDH activator
Bacillus
MGKLFEEKTIKTEQIFSGRVVKLQVDDVELPNGQTSKREIVRHPGAVAVIAITNENKIVMVEQYRKPLEKSIVEIPAGKLEKGEDPRVTALRELEEETGYECEQMEWLISFATSPGFADEIIHLYVAKGLSKKENAAGLDEDEFVDLIELTLDEALQYIKEKRIYDSKTVIAVQYLQLQEALKHK
Involved in the activation of the NAD-dependent methanol dehydrogenase (MDH). MDH activation by Act involves hydrolytic removal of the nicotinamide mononucleotide (NMN) moiety of the NAD cofactor, changing its ping-pong type of reaction mechanism into a ternary complex reaction mechanism. It requires the presence of magnesium ions and is also able to use ADP-ribose.
Q8KP10
Q8TIR7
NIKR3_METAC
Putative nickel-responsive regulator 3
Methanosarcina
METELMRIGVSLPDTLLSKFDEIIEKRGYSSRSEGIRDAIRSYISYYEWMGDIKGHRVGTVAVIYDHTKRGLSNALADIQHHYSHLIKSSVHIHLDHDNCFEVIVLDGDGEEIKELAEAIMALKGVKFSKLTTVASNEKI
Transcriptional regulator.
Q8TIR7
A0RVX8
RL22_CENSY
50S ribosomal protein L22
Cenarchaeum
MGDFGYSFEGYDPTRHVRASLREKQISHKHAREISLHIRGMTVEKARDFLQAVIEKKRAVPFRRFKRQVGHRSDPGVMAGRYPEKSAAEFIKLLDNLESNAEYKGMDLDRLTIVGAVAHKGILIKRFIPRAMGRSTPKNNVLTHVELVAREA
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
A0RVX8
P0DUJ1
APOE_PTEGI
Apolipoprotein E
Pteropus
MKFLWAALVVTLLAGCQADVEEEVKLGQEPDRWQAKQPWEQALGRFWEYLRWVQTLSNKVKEELLNSQVTEELKLLIEETMKEVKAYKEELEKQVGPIAQETQARLSKELQAAQARLESDMEDVRTRLAQYRSEAQAALGQNTDDLQGRLASHLRKLRKRLLRDAEDLQKRLAVYQAGTREAAERGVSAVHERLGPLMMEGPLQAIPPSQQLRERAEAWGQKVRGRLESVGSQARDRLDDMRDQMEELKAKVEEQASQVRLQAEAFQTRLKSWFEPLVQDMQRQWASLVEKVQSSLGISPSTKPSKTK
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
P0DUJ1
Q5FM85
RL22_LACAC
50S ribosomal protein L22
Lactobacillus
MAEQISSAKAEARTVRIAPRKARLVIDLIRGKSVAEALAILEFTPRAASPIVEKVLRSAIANAEHNYDLESANLYVSEAYVNEGATLKRFRPRAKGMASPINKRTSHVVVVVSEKND
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Q5FM85
A1L224
CR3L2_DANRE
Processed cyclic AMP-responsive element-binding protein 3-like protein 2
Danio
MEIMDSGEPFLQWDKNLSELSEAGENDILYSTHFTDLLDDLSQEALLGQLLSDPFLSGRGDAMDTEEELTRASPVPPHIQAEHSYSLCGDSRPQSPLSHLPGEPGSDAADSESDEWPMEQEDKGIKMEPLLCVPLPALTLTVTPAGSAPEPVIDSCDSAQSLSLPQVKEDSNSPQIKLEPHEVDQFLNLSPKGLECLQMPPTPPSSVGSDSEGSQSPVHPCAPASPTQTPAVLKVAPRAPSSLSSSPLLTAPHKLQGSGPLLLTEEEKRTLIAEGYPVPTKLPLSKAEEKALKKIRRKIKNKISAQESRRKKKEYVDALEKKVETCSNENHELRRKVENLECTNKSLLQQLHSLQAVVAGKVPRSCRVTGTQTSTCLMVVVLCFSLFLGSFYPGLSPCSSITKADLSREISIHDSYTTTVKSRSLLSIQEPGGLDEPHPIGLGGEYPEWDRQADVMAAWRFEQQHKEEEAELHKAEHRPLLLSTNETHAQKAILIDLHTHRSNETAKVIQLDRTVNETS
Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/mbtps1 and S2P/mbtps2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis. May protect neuroblastoma cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site.
A1L224
Q2LZ59
MOB2_DROPS
Mps one binder kinase activator-like 2
Sophophora
MKETLSSKVPTTRTVGVTFDSVSESKSKLKSGSVQGTTATATATGPPSPPSSYVIKCLLKTARFMWQVTTIPAKIGDTLGTLYRYAQDSVDTFLCVAGKARRKERDGDQNSTDTKLYLEESVLERKLPEADLKALVDLPAGLDYNEWLASHTLALFEHVNLVYGTISEFCTQSGCADMTGPGNRTYLWFDEKGKKTRVAAPQYIDYVMTFTQKTVSDESIFPTKYANEFPGSFESIARKILRLQFHVIAHLYAAHFREIALLGLHTHLNLTFAHLTALHRRFNLIDEKETDVLRDLEVALRLTDDTSGQDSSSSVHEHSSSSSSPPVQHQQHQHQQQHNNSSSTSNSTSPAEALHVNSQSNSNSHSNSSNSHTTTASASASLIDGDSAAPPICTQPEAGAGCKPAGSSGLLGGILGDLTSGEFGDTTRYCTSAVPQAAASSSASAAGPGADGAASAALNNGAGALHLNFSNNNNNNHNLNHLNHHHHHHHHQHHHQHHPHGHHGHQGHQGHQGHHQAPASTTVPHSGLIQCNAAGAVGASAGGGGNAVSAATGGATSASSTA
Required for the normal morphogenesis of a variety of polarized outgrowths including epidermal hairs, bristles, arista laterals, and dendrites.
Q2LZ59
P14614
GLUB4_ORYSJ
Glutelin type-B 4 basic chain
Oryza sativa
MATIAFSRLSIYFCVLLLCHGSMAQLFGPNVNPWHNPRQGGFRECRFDRLQAFEPLRRVRSEAGVTEYFDEKNEQFQCTGTFVIRRVIEPQGLLVPRYSNTPGMVYIIQGRGSMGLTFPGCPATYQQQFQQFLPEGQSQSQKFRDEHQKIHQFRQGDIVALPAGVAHWFYNEGDAPVVALYVFDLNNNANQLEPRQKEFLLAGNNNREQQMYGRSIEQHSGQNIFSGFNNELLSEALGVNALVAKRLQGQNDQRGEIIRVKNGLKLLRPAFAQQQEQAQQQEQAQAQYQVQYSEEQQPSTRCNGLDENFCTIKARLNIENPSHADTYNPRAGRITRLNSQKFPILNLVQLSATRVNLYQNAILSPFWNVNAHSLVYIVQGHARVQVVSNLGKTVFNGVLRPGQLLIIPQHYVVLKKAEHEGCQYISFKTNANSMVSHLAGKNSIFRAMPVDVIANAYRISREQARSLKNNRGEELGAFTPRYQQQTYPGFSNESENEALE
Seed storage protein.
P14614
O74844
CENPQ_SCHPO
Sim4-mal2-associated protein 7
Schizosaccharomyces
MEMKRRVRAVRRDQIQKRWRPLEDKQRQEIIIIFRTCSRLVLNTIKSETRKSLAEEWFMNILLKIEAPLRNLPVPRKRKESILFSQLLSSNMQLEQQLYSDLDHINVLQQELKVETARLENEQKSYEEMKQNMAINNSRLADLKSKLHPYLKKGLKISHDNFSDSNDFSFQKKLNTEDSNTSKTSTLDMYKEKLKPFTKTMQIHANKTVQLSQTIQKATLLLQRLNNTKNIGLNKSSKLKIKNI
Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore COMA complex, which connects centromere-associated proteins and the outer kinetochore. COMA interacts with other inner kinetochore proteins to form the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.
O74844
A1SYY2
UREE_PSYIN
Urease accessory protein UreE
Psychromonas
MLQVFERLDHTHDEISDSITLDQDTRKKSRIKSVTDKGANIGIFVERGHPLLVGEILKTECGLLIEVKGKAEDVSTAVANDWLNFSKVCYHLGNRHTTLQIGELWVRFKPDHVLEQLAENYGLSVNSIPAVFEPENGAYGVRSHGHSHAHDS
Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly.
A1SYY2
Q2NRH3
TYSY_SODGM
Thymidylate synthase
Sodalis
MKQYLDLMRRVRAQGTPKADRTGTGTLSIFGHQMRFDLRQGFLLVTTKRCHLRSIIHELLWFLNGDTNIAYLQQNNVSIWDEWADDNGDLGPVYGRQWRAWGTSDGRQIDQLAEVVRQLKQDPDSRRIIVSAWNVGELDKMALAPCHALFQFYVANGTLSCQLYQRSCDIFLGLPFNIASYALLVHMLAQQCDLQVGDFVWTGGDTHLYSNHLQQADLQLTRDPLPLPQLLIKRRPATLFDYRFEDFELTGYDPHPAIKAPVAV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Q2NRH3
Q3A9Q4
RL10_CARHZ
50S ribosomal protein L10
Carboxydothermus
MKPIIEQKAKVVAEIEEMIKSSQAAILVDYRGLTVAEMTELRRKLKEKGAEIKVVKNTLAKRAAHNLGITGLDPYLEGPTALAVAKEDPASAAKVLFDFAKDHPNLEIKVGILENIVLEKDQVKAIADLPPRNVLLAKLLGGMQAPLYGFAGALAGMLRKFVYALEAIRKQKAGEE
Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.
Q3A9Q4
Q3AC01
PYRC_CARHZ
Dihydroorotase
Carboxydothermus
MGMLIKNGNVVMVEDGKIRKMDVLIDKGIIVEISPEINRSDVEVIDIEGKFLIPGLIDMHVHFRDPGYTHKEDIHSGSNAALAGGFTGVLMMPNTDPPPDNATVIYYWKEKSKSIPLNILFSGCITKNRAGKELSKFYELKEAGAVAITDDGNWVADGAVFRHAMEYAAALDLLVITHPEEPTIANRGVINEGYWSTVLGLRGIPKAAENIAIYRDIEIAKMTGAKLHVAHLSTAEGVRLVAAAKKLGLKVTAEVTPHHLVLTDEALAGYDTNLKVNPPLREAEEQKALLKGLLEGVIDVIATDHAPHASYEKNVEFNDAPFGIEGLETAFPVLYTELVLKKKITLEKLLLKMTVNPAKILQLPKQGDIKKGNYANLTVIDPKLTLKVSEELLVGKSKNNPFLGRTLTGWPVMTVYQGIVAYQRLLKGVQ
Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
Q3AC01
B4SU91
SPEE_SALNS
Spermidine synthase
Salmonella
MAENTMWHETLHDQFGQYFAVDNVLYHEKTDHQDLIIFENAAFGRVMALDGVVQTTERDEFIYHEMMTHVPLLAHGHAKHVLIIGGGDGAMLREVTRHKNVETITMVEIDAGVVSFCRQYLPNHNAGSYDDPRFTLVIDDGVNFVNQTHQTFDVIISDCTDPIGPGESLFTSAFYEGCKRCLNPGGIFVAQNGVCFLQQDEALDSHRKLSHYFSDVGFYQAAIPTYYGGIMTFAWATDNGALRHLSSEIIQARFHAAGLKCRYYNPAIHAAAFALPQYLHDALSAQ
Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
B4SU91
Q12T12
PCKA_SHEDO
Phosphoenolpyruvate carboxykinase (ATP)
Shewanella
MTDGAPRTFLNPTSAELVEIALQRGEGRLTANGALVALTGARTGRSPADRFIVKEPSSEADIEWGPVNKPFDAGAFDALWGRVEAYLSEKELFVSELEVGADDEHYLPVRVTTEYAWHQLFARNLFITPEHFNRGDKGVWQIINAPGFVCDPSRDGTHSDAVVILNFAERKVLLAGLKYAGEMKKSMFSVQNFLLPAKGVLPMHCSANVGQDGDTTLFFGLSGTGKTTLSADPKRFLIGDDEHGWAKGGVFNIEGGCYAKCIDLSQKNEPVIWDAIRFGTVLENVMLDENRVPNYKDSSLTENSRAAYPLEHIAQRKVENRGNEPHAVVFLTCDVSGVLPPVSILTKEQAAYHFLSGYTAKVGSTEMGSTSAIQSTFSTCFGAPFFPRPAGVYAELLIERIESFNSQVYLVNTGWTGGPHGVGKRFDIPTTRAIVDAIVSGSLKDAPTEHLATLNLAVPLAIEGVDSTLLNPINTWADKDMYAKYAKQLAQEFNSNFAKYQVSEAIKQAGPKA
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
Q12T12
Q03RR0
NUSB_LEVBA
Antitermination factor NusB
Levilactobacillus
MTLTRHQIRERAFQMLFALNANPEADHDALYQRVLTDDPNQLVPVPDYLATLVNGVLAHQSELDAQIDQYLSTGWQLKRIAKTDLVILRMAFYEIEHVDDVPNRVAVNEALELAKNFSDDRSRRFINGVLAHTLDDETDTQA
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
Q03RR0
Q9NPI6
DCP1A_HUMAN
Transcription factor SMIF
Homo
MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISSPGLQPSTQLSNLGSTETLEEMPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPAVVGLDSEEMERLPGDASQKEPNSFLPFPFEQLGGAPQSETLGVPSAAHHSVQPEITTPVLITPASITQSNEKHAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPRNSTMMQAVKTTPRQRSPLLNQPVPELSHASLIANQSPFRAPLNVTNTAGTSLPSVDLLQKLRLTPQHDQIQTQPLGKGAMVASFSPAAGQLATPESFIEPPSKTAAARVAASASLSNMVLAPLQSMQQNQDPEVFVQPKVLSSAIPVAGAPLVTATTTAVSSVLLAPSVFQQTVTRSSDLERKASSPSPLTIGTPESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay . Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP . Contributes to the transactivation of target genes after stimulation by TGFB1 . Essential for embryonic development .
Q9NPI6
A6VN13
ORN_ACTSZ
Oligoribonuclease
Actinobacillus
MAQDKENLIWIDLEMTGLDPEQERIIEIATIVTDKNLNILAEGPVLAVHQPNQLLDKMSDWCIKTHTANGLVERVKASKLTERAAELQTIDFLKLWVPKGASPICGNSVAQDKRFLFKYMPDLADYFHYRHLDVSTLKELARRWKPEISDGFQKANTHLALDDIRESIKELAYYREHFIKLD
3'-to-5' exoribonuclease specific for small oligoribonucleotides.
A6VN13
A2S6L0
MNMG_BURM9
Glucose-inhibited division protein A
pseudomallei group
MLYPTEFDVIVVGGGHAGTEAALASARMGAKTLLLTHNIETLGQMSCNPSIGGIGKGHLVKEVDALGGAMAAATDEGGIQFRILNSSKGPAVRATRAQADRVLYKQAIRRRLENQPNLWLFQQAVDDLMVEGDRVVGAVTQVGVRFRARAVVLTAGTFLDGKIHVGLNHYTGGRAGDPAAVSLSSRLKELNLPQGRLKTGTPPRIDGRTIDFSKLDEQPGDLDPIPVFSFLGRAEQHPQQLPCWVTHTNERTHDIIRSGLDRSPMYTGVIEGVGPRYCPSIEDKIHRFASKDSHQIFLEPEGLTTNEFYPNGISTSLPFDVQLALVHSMRGLEQAHILRPGYAIEYDYFDPRALKSSLETKAIGGLFFAGQINGTTGYEEAAAQGLLAGINAGRYAQEKDAWCPRRDQAYLGVLVDDLVTRGVSEPYRMFTSRAEYRLSLREDNADMRLTEIGRELGVVDDVRWDAFNRKRDAVSRETERLRTTWVTPKTLPADEATALLGKPIDHEYSLAELLRRPGVSYDGVCGLRGGECGPSEPLAEDELLLAQIKEQIEIGIKYQGYIERQAGEIERNGANENTRLPDGIDYTEVRGLSFEVSQKLNQFRPETIGQASRISGMTPAAISLLMVHLKKRGLGRRKGADSVPGADVQADNTAAQQ
NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
A2S6L0
A0LUE6
POTA_ACIC1
Spermidine/putrescine import ATP-binding protein PotA
Acidothermus
MTDYTPDETPGIALRDISKVYSSRTGDVVAVHALTLAVRSGEFFSLLGPSGCGKTTTLRMIAGFEEPTTGRILLEGRDVTDVPPHRRDVNMVFQNYALFPHLTVWENVAFGPKRKKLPREEIRRRVGEALELVDLVGREKRRPDELSGGQQQRVALARALVNRPRALLLDEPLGALDLKLRQAMQLELKRIQREAGVTFVYVTHDQGEALTMSDRIAVMNAGRVEQLGTPREIYETPSTPFVAGFIGTSNVISAPLARIEGAIALLATSADERVLVPLRVPVPPGASISATVRPEKIRLSLHPPDGDRCRLLGVVREVVYLGTATQYVVATSVAEQLVVYAQNDGTADLVPAPGDRIWLWWRPEHGYQLIHADATDVPEEAAP
Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.
A0LUE6
P35634
FLA2_BARBA
Flagellin
Bartonella
GAAILTNDNAMDALQDL
Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. Flagella are an important component in the invasiveness of B.bacilliformis.
P35634
B8DJT5
DAPB_DESVM
4-hydroxy-tetrahydrodipicolinate reductase
Desulfovibrio
MSTSIIVTGAGGRMGSTICRMAQEDPVLTLAAVVERPERLASLDVWKCPSGSDPDAVFATVPGGVVVDFTSPEASMANARAAARAGVSHVIGTTGLTAEQKAELADLARTARIFWAPNMSIGVNVLLKILPQLVQQLGEQYDLEMVELHHNRKKDSPSGTALRLAECLAEARGWNLPDVANYHREGIIGERPKDEIGIQTIRGGDVVGVHTIYAMGPGERIEITHQAHSRENFAQGALRAAKWLPQQQPGTLYSMLDML
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
B8DJT5
P27214
ANX11_BOVIN
Calcyclin-associated annexin-50
Bos
MSYPGYPPPAGGYPPGAPGGGAWGGAGYPPPTMPPIGLDNVANYAGQFNQDYLSGVAANMSGTFGGANVPNLYPGAPGGGYPPVPPGGFGQPPPAQQPVPSYGMYPPPGGNPTSGMPSYPPYPGAPVPGQPMLPPGQQPPGVYPGQPPMTYPGQSPVPPPGQQPVPSYPGYSGSGTVTPAVSPAQFGNRGTITDASGFDPLRDAEVLRKAMKGFGTDEQAIIDCLGSRSNKQRQQILLSFKTAYGKDLIKDLKSELSGNFEKTILALMKTPVLFDAYEIKEAIKGAGTDEACLIEILASRSNEHIRELNRVYKTEFKKTLEEAIRSDTSGHFQRLLISLSQGNRDESTNVDMTLVQRDVQELYAAGENRLGTDESKFNAILCSRSRAHLVAVFNEYQRMTGRDIEKSICREMSGDLEQGMLAVVKCLKNTPAFFAERLNKAMRGAGTKDRTLIRIMVSRSEIDLLDIRAEYKRLYGKSLYHDITGDTSGDYRKILLKICGGND
Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis.
P27214
A1WBI7
PANB_ACISJ
Ketopantoate hydroxymethyltransferase
unclassified Acidovorax
MTDSPTAGTPYGTLPPASPLPQRRPVSLPRLAQMREAGEKITMLTAYDATFAAVADAAGVECILVGDSLGMVCQGLPSTVGVTLEHMAYHTASVARGLHRVQGTAWLIADLPYGSYAESREQALRSACQLMQAGAHMVKLEGGGWTAPTVQFLVERGVPVCAHLGLTPQTVHALGGYRVQGKGDQAAQQLRRQALELQDAGAAMLVLEMVPTPLARDLTQALPRCHTIGIGAGSGTAGQVLVMHDMLGINLGKNPKFVHDFMRDAGSVRGAIEAYVQAVKQGRFPDDALHAWN
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
A1WBI7
Q6P8Y0
CF161_MOUSE
Cilia- and flagella-associated protein 161
Mus
MAQNVYGPGVRMGNWNEDVYLEEERMRHFLEKREKGELLIQRNRRVKKNILRPMQLSVSEDGYVHYGDKVIIVNPDQVLGEEAGKFMRGDLSLCMSPDEVKAQLSDDLEIPCGVSAVQTIAPMGRNTFTILSDGANSCEMGQVVVYGQNFCLGIAAGLEGKMLYLTSDHRTLLKSSLKSGLQEVTLTDEVTHLNCWQAAFLDPQLRLEYEGFPVRANEKIVIYHRHTNRALAVHRNLFLRTYFGKEMEVVAHTYLDSHKVEKPKNQWMLVTGNPRNKSNTMLDISKPITEDTRALEQAMGINT
Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating.
Q6P8Y0
Q9M0G7
MIK1_ARATH
Protein PHLOEM INTERCALATED WITH XYLEM-LIKE 2
Arabidopsis
MKMKIIVLFLYYCYIGSTSSVLASIDNVNELSVLLSVKSTLVDPLNFLKDWKLSDTSDHCNWTGVRCNSNGNVEKLDLAGMNLTGKISDSISQLSSLVSFNISCNGFESLLPKSIPPLKSIDISQNSFSGSLFLFSNESLGLVHLNASGNNLSGNLTEDLGNLVSLEVLDLRGNFFQGSLPSSFKNLQKLRFLGLSGNNLTGELPSVLGQLPSLETAILGYNEFKGPIPPEFGNINSLKYLDLAIGKLSGEIPSELGKLKSLETLLLYENNFTGTIPREIGSITTLKVLDFSDNALTGEIPMEITKLKNLQLLNLMRNKLSGSIPPAISSLAQLQVLELWNNTLSGELPSDLGKNSPLQWLDVSSNSFSGEIPSTLCNKGNLTKLILFNNTFTGQIPATLSTCQSLVRVRMQNNLLNGSIPIGFGKLEKLQRLELAGNRLSGGIPGDISDSVSLSFIDFSRNQIRSSLPSTILSIHNLQAFLVADNFISGEVPDQFQDCPSLSNLDLSSNTLTGTIPSSIASCEKLVSLNLRNNNLTGEIPRQITTMSALAVLDLSNNSLTGVLPESIGTSPALELLNVSYNKLTGPVPINGFLKTINPDDLRGNSGLCGGVLPPCSKFQRATSSHSSLHGKRIVAGWLIGIASVLALGILTIVTRTLYKKWYSNGFCGDETASKGEWPWRLMAFHRLGFTASDILACIKESNMIGMGATGIVYKAEMSRSSTVLAVKKLWRSAADIEDGTTGDFVGEVNLLGKLRHRNIVRLLGFLYNDKNMMIVYEFMLNGNLGDAIHGKNAAGRLLVDWVSRYNIALGVAHGLAYLHHDCHPPVIHRDIKSNNILLDANLDARIADFGLARMMARKKETVSMVAGSYGYIAPEYGYTLKVDEKIDIYSYGVVLLELLTGRRPLEPEFGESVDIVEWVRRKIRDNISLEEALDPNVGNCRYVQEEMLLVLQIALLCTTKLPKDRPSMRDVISMLGEAKPRRKSNSNEENTSRSLAEKHSSVFSTSPVNGLL
Involved in the regulation of procambium maintenance and polarity during vascular-tissue development . Involved in the pollen tube perception of the female signal . Phosphorylates MDSI1 .
Q9M0G7
Q7MAE2
CH10_WOLSU
Chaperonin-10
Wolinella
MNFKPLGQRVLVERLEEDTKTASGIIIPDNAKEKPLMGTVKALSEEVAKEGLLKAGSQVVFAKYSGTDVKLEGKEYLILKVEDLLGTIE
Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.
Q7MAE2
Q634Q3
END4_BACCZ
Endonuclease IV
Bacillus cereus group
MLKIGSHVSMSGKKMLLAASEEAVSYGATTFMIYTGAPQNTRRKPIEELNIEAGRKHMEQNGIEEIIVHAPYIINVGNTTKPETFQLGVDFLRMEIERTSALGVAKQIVLHPGAHVGAGADAGIQQIIKGLNEVLTPDQTVNIALETMAGKGTECGRSFEEIAKIIDGVKYNEKLSVCFDTCHTHDAGYDIVNDFDGVLNEFDKIVGIDRLQVLHINDSKNVRGAGKDRHENIGFGHIGYKALHHIVHHPQLTHVPKILETPYVGEDKKDKKPPYKLEIEMLKNGTFDEGLLEKIKAQ
Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
Q634Q3
B8ZPZ6
FUCI_STRPJ
FucIase
Streptococcus
MIQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLKYPDGEPVECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDIPHAIWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEANDTDIPEDVKEKLLRYARAALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGMRNESVDMTEFTRRMDRGIYDPEEFERAMVWVKEHIKEGVDRNREDLILSKEEKEKQWEFVIKMFMIGRDLMVGNPRLAELGFEEEAVGHHALVAGFQGQRQWTDHFPNGDFMETFLNTQFDWNGIRKPFVFATENDSLNGVSMLFNYLLTNTPQIFADVRTYWSPEAVERVTGYTLEGRAAAGFLHLINSGSCTLDGTGQATRDGKPVMKPFWELDESEVQAMLENTDFPPANREYFRGGGFSTRFLTKGDMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPTTWFAPRLTGKGAFKSVYDVMNNWGANHGAITYGHIGADLITLASMLRIPVNMHNVPEEDIFRPKNWSLFGTEDLESADYRACQLLGPLHK
Converts the aldose L-fucose into the corresponding ketose L-fuculose.
B8ZPZ6
Q1LSE1
GATA_CUPMC
Glutamyl-tRNA(Gln) amidotransferase subunit A
Cupriavidus
MPFSADSVTSLRQIADALAARSVSAEELAREYLARIEAGRALNAFVAVDPELTLAQARAADERRAQGQATPLTGVPIAHKDVFVTRGWKSTAGSKMLANYESPFDATVVERLAAAGMVTLGKTNMDEFAMGSSNENSFFGPVSNPWDTSRVPGGSSGGSAAAVAAGLAPAATGTDTGGSIRQPASFSGITGIKPTYGRVSRYGMIAFASSLDQGGPMAHSAEDCALLLNGMAGFDPKDSTSLTPELGGVTEDFTRLLGQPRAGATASQPLAGLRIGLPREYFGKGLSADVEQALRAALAEYEKLGATLVDVTLPKTELSIPVYYIIAPAEASSNLSRFDGVRYGHRAAQYGDLLDMYKKSRAEGFGPEVKRRIMVGTYVLSHGYYDAYYLQAQKIRRIIADDFQRAFTQCDVIMGPVAPTVAWKLGEKTADPVQMYLADIFTLSTSLAGLPGMSVPCGFGEGNMPVGLQLIGNYFDEAQLLQTAHAFQQATDWHLRRPA
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Q1LSE1
Q7N8L0
CYSN_PHOLL
Sulfate adenylate transferase
Photorhabdus
MSALAQNETIAHQIKQQGGVEAYLHAQQEKGLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSTLQNDSKRIGTQGEKLDLALLVDGLAAEREQGITIDVAYRYFSTEKRKFIIADTPGHEQYTRNMATGASTCDLSILLIDARKGVQEQTRRHSFISTLLGIRHLVVAVNKMDLMEYRQEVFNQIKQDYMNFAGQLPTNLDVHFVPISALDGDNIVTISRNMDWYEGPTLLDILETVDVKKEASKQLLRFPVQYVSRPDLDFRGYSGTLSSGILRKGQKVKVMPSGICSQVERIVTFDGDLDFAVPGEAITVVLKDEIDISRGDLLISADDEMMVTRHALVDVVWMSEQPLVQGQNLDIKVAGKKSRGKVENIQYQVDITHLTQRVAVDLPLNAIGSVEFSFEEPLMLDSYQQNSDTGGIILVDRLTNVTVGAGLVREIQTDVYEGPKEFSEFELELNRLIRRHFPHWGARDLLGGK
With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.
Q7N8L0
P0DMS5
APOA1_OCTDE
null
Octodon
MKAVVLAVAVLFLTGSQARHFWQRDDPQTSWDRVRDFATVYVDAVKESGRDYVAQLEASLGKHLNLKLLDNWDTLSTTFSKLRSELGPVTQEFWDNLEKDTEWLRQEMNKDLVEVKEKVQPYLKNFQEKVQLELEHYRKKVEPLGTDLRDGARQKLQELQEKLTPLGEDLRDRARQHVDELRAQLGPYSDQMRQRLTQRLEALKDSASLAEYQAKAQEHLKTFSEKAKPALEDLRLGLLPVLESLKASFLSSIDEVSKKLSAQ
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
P0DMS5
B9JA09
LPXK_AGRRK
Lipid A 4'-kinase
Agrobacterium tumefaciens complex
MVSEAPPFWWRKPDWRAWGLSPFSFLYGRVAGHRMVHGRRASVPVPVICVGNFTVGGAGKTPTALALARAAKTKGLKPGFLSRGYGGSLDVTTVVDPHDHHATAVGDEPLLLAREALTVIARRRADGAERLVREGADLIIMDDGFQSAQLAIDYALVVIDATRGIGNGHLVPGGPVRAPLRTQLGYTSGLLKVGDGNAADRIVRLAARAGKPFFSASIKTLGQEDLQGRKVLAFAGIADPTKFFRTVETLGAGIAVRRSFGDHEHLEEDEIADILDVADRDGLEIVTTSKDYVRLIGHHGRADELLARCRVIEIAMVFDDPHAPELIIDRAIAAARERRLREGWTGKTLLPSGEK
Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).
B9JA09
P49279
NRAM1_HUMAN
Solute carrier family 11 member 1
Homo
MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG
Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
P49279
B7UNT3
ARGE_ECO27
N-acetylornithinase
Escherichia
MKNKLPPFIEIYRALIATPSISATEEALDQSNADLITLLADWFKDLGFNVEVQPVPGTRNKFNMLASCGQGAGGLLLAGHTDTVPFDDGRWTRDPFTLTEHDGKLYGLGTADMKGFFAFILDALRDVDVTKLAKPLYILATADEETSMAGARYFAETTALRPDCAIIGEPTSLQPVRAHKGHISNAIRIQGQSGHSSDPARGVNAIELMHDAIGHILQLRDNLKERYHYDAFTVPYPTLNLGHIHGGDASNRICACCELHMDIRPLPGMTLNELNGLLNDALAPVSERWPGRLTVDELHPPIPGYECPPNHKLVEVVEKLLGAKTEVVNYCTEAPFIQTLCPTLVLGPGSINQAHQPDEYLETRFIKPTRELITQVIHHFCWH
Catalyzes the hydrolysis of the amide bond of N(2)-acetylated L-amino acids. Cleaves the acetyl group from N-acetyl-L-ornithine to form L-ornithine, an intermediate in L-arginine biosynthesis pathway, and a branchpoint in the synthesis of polyamines.
B7UNT3
Q52331
KORC2_ECOLX
Transcriptional repressor protein KorC
Escherichia
MSDVNIRLECLRPAERWVQPTGAEIREVLHLAGLTGGQAARILGLGAKGDRTVRRWVGEDSPIPYAAWAILCDLAGIGAIWKGQG
Acts with KorA as corepressor in the control of the kilC and kilE operons.
Q52331
A5UE39
TPIS_HAEIE
Triose-phosphate isomerase
Haemophilus
MARRPLVMGNWKLNGSKAFTKELIEGLKAELHDVTGCDVAIAPPVMYLGTAEAALSGCGCNCGGKSVIQLGAQNVDINVKGAFTGDISTEMLKDFGAKYIIIGHSERRTYHKESDEFVAKKFGALKEAGLVPVLCIGESEAENEAGKTEEVCARQIDAVINALGVEAFNGAVIAYEPIWAIGTGKSATPAQAQAVHAFIRGHIAAKSQAVAEQVIIQYGGSVNDANAAELFTQPDIDGALVGGASLKAPAFAVIVKAAAAAKN
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
A5UE39
C4L1C9
TYSY_EXISA
Thymidylate synthase
unclassified Exiguobacterium
MKQYHDLCRHILDQGVVKEDRTGTGTTSVFGYQMRFNLQEGFPLITTKKLHIRSIIHELLWFISGETNVRYLQDNGVRIWNEWADEEGNLGPVYGSQWRSFPRPDGSSVDQLAQVIEQIKTNPDSRRLIVSAWNPGQLEEMALPPCHLLFQFYVADGKLSCQLYQRSADTFLGVPFNIASYALLTHMVAHVTGLEVGDFVHTLGDAHIYHNHLEQVELQLSRDPRPLPKLNIVRDVSSIESFRFEDFEILGYDPHPHIKGEVSV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
C4L1C9
Q1LSZ8
FETP_BAUCH
Probable Fe(2+)-trafficking protein
Candidatus Baumannia
MSKNIYCVFLRKQAEGQDFQSYPGELGKHIFNNISKEAWAKWQQKQTMLINENKLNLISNTDRNFLEKEMIKFLFKS
Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes.
Q1LSZ8
Q34800
COX1_SYMSY
Cytochrome c oxidase polypeptide I
Symphalangus
MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASAMVEAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIVTHYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGSDTKWSAAVLWALGFIFLFTVGGLTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFVHWFPLFSGYTLDQTYAKIHFAIMFVGVNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKRKILMIEQPSTNLEWLYGCPPPYHTFEEPVYMKP
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
Q34800
B3QYF4
GUAA_CHLT3
Glutamine amidotransferase
Chloroherpeton
MNSVIVLDFGSQYTQLIARRIRELGIYSEILPYHTSAEALRERNPKALILSGGPTSVYDAFAPMPDEKIYELDIPILGICYGLQAIAKHFGGEVAASPKREFGRAQMNIVRQNELAESLLFKNIPDSTVWMSHSDKLTCLPKGFHITAQTANSELCAIEVTEGEGAHRIFGLQFHPEVHHTEFGEKLLSNFLINIAGITPDWSPQSFIDSEIARIKELVGDQTAICAISGGVDSSVAAVLVSRALGDKLHCIFVDNGLLRKNEAEKVQEKLKQLGLNLTTVDASELFLSRLKNVVSPERKRKIIGRTFIKVFEEHIHNEKFLVQGTLYPDVIESVSVKGPSQTIKTHHNVGGLPKRMKLKLIEPLRELFKDEVRKVGKLLDVPDEILTRHPFPGPGLAVRVLGSVSKERLDVLREADAIFIDELKKHDLYLQIWQAFTVLLPVQTVGVMGDNRTYENAVALRAVNSTDGMTADWARLPNDFLAHVSNRIINEVRGINRVTYDISSKPPATIEWE
Catalyzes the synthesis of GMP from XMP.
B3QYF4
Q9UU96
GRC3_SCHPO
Polynucleotide 5'-hydroxyl-kinase grc3
Schizosaccharomyces
MVKRQRIESSNVPLSAFAVRQLTLSKAARKKDNSSGKKRSVSEEESQDKYEDEMKTEGEFPSYKHTLVQVVVPGVDHRTKLHSESSKNDSEITPDINRSKVNPQEYSEFSVASPQTISPSLPLNLDDETVSENVPHSPQSSNDAIPVIKITEENSFRVKDTLYVGLHKDQKLAMVGTFIFRSVRGKFQLFGATYSSACMSWFPLNAPLAFATPVFSAIDNALPAMQISEYEEDSLNLRSFAVPSYSPKEHEYELEPKDILPNFETVIAFRENENGLSKIARVLPFAKRLFSFKNLLQDASSISNNFEITPESWCSFSNQLLFSTSKSDYVVPRLMVCGPKGSGKSSFSRYITNRLLQQYRHIAYLDLDPGQPEVVPSGHISLYYINSPLQGPVFARMLFPTYMLRLHLGDISPQKDPDHYIACVTRLFAEYKDYIFNQEISQKEIIPLIINCPGWIRGGGAELLSSIVDICQPTEVVYMSREDMKSSHREKKSIYQHKEYMPDFLSSRDEFQLTLLESTWQYLPDPNVNKVTSADNRMLGLLSYLYFNCNLQRWDFTTSLTACQPIATAFKGSSKGIDAVNIIGEPLNVNDVAKTINGTLMALYACDTASLDNSNTQRIVSSPEGIPLIINDGLPLDPNTSHCLGLIVLRTIDLKRNEFHFVGPLNLELIKDAYAKSLKIVLERGRLELPVYAMLDHRLAQYSELPYLDRNHDRVAVGAHRRRVRRNIIRRSTFVG
Polynucleotide 5'-kinase required for both rRNA processing and heterochromatic gene silencing.
Q9UU96
Q6DGB6
CC103_DANRE
Protein schmalhans
Danio
MENSDVINFSCLEKELHSALQADRKYQRENDAKFRALNQKVASYEEFRDIVLASHLKPLDRNDISGSPRKQPWNPVACRTNYVCASSEQVQPQLSEVQPRSASEFIRDWRRFAGCSFEKYSLLVSLGGEALQKIFSTEIGLGLLGEFLLILSQCLKSGDEDRVTGVLDGLSKTGRFSINLSLLSQAEQEACEELFNKLKVAAGECHPYKDNSNTSVVCEAGLTHMEDNKTDITTTLKELAGKYGTEK
Dynein-attachment factor required for cilia motility.
Q6DGB6
Q6B8W7
RK6_GRATL
50S ribosomal protein L6, chloroplastic
Agarophyton tenuistipitatum
MSRIGKKPINLPQNINITIIENNVQIQGPKGELSYKIPKLIQIKQDTKNNKLFLYKTEDNKEAQKLHGLCRTLINNMIIGVSQGFEKKLQIQGVGYRSQLDGDNLLLNVGYSHTVIVKPPKNIILEVENNTSITIKGIQKEQVGEIAAQIRRIRPPEPYKGKGIRYLNETINLKVGKSGK
Binds 23S rRNA.
Q6B8W7
Q4R6H1
NDUAD_MACFA
NADH-ubiquinone oxidoreductase B16.6 subunit
Macaca
MAVAVCHFRLGPEVWNTASMEMPKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLVYGHWSIMKWNRERRRLQIEDFEARIALMPLFQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPLIGELYGLRTTEETIHANYGFMWYT
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes.
Q4R6H1
Q18B40
FABH_CLOD6
3-oxoacyl-[acyl-carrier-protein] synthase III
Clostridioides
MNTKAGILGVGSYLPEQSYDNFHFEKIMDTSDEWISTRTGIKERRFAKESEATSDLASKAALKAIECAKLNVEDIELIILATITPDMSLPSTACIVQDAIGAVNATAFDISAACSGFVYGVTIAKQFVETGCYKNVLVIGAETCSKFLNYDDRTTAVLFGDGAGAAVIGPVNEGGILSTHMGSDGKGKDCLKVPAGGSRLKASKETVEANLHTIEMAGSDVFKFAVRKMAETSLRALEKANLNTTDIDYLVPHQANIRIIQASSKRLELDMKKVYVNIDKYGNMSAASIPVALDEAYREGKIKKGDNVVLVGFGGGLTWGASVVKWTL
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.
Q18B40
A1TPZ6
FOLD_ACIAC
Methenyltetrahydrofolate cyclohydrolase
Acidovorax
MTAQLIDGNALSRQLRADVARRAALLKERGTTPGLAVVLVGDNPASQVYVRNKVKACEESGLHSVLEKYDAAMSEAELLARVDALNNDPSIHGILVQLPLPAHIDAQKVIEAISPAKDVDGFHIASAGALMTGMPGFWPCTPYGCMKMLEHIGYDLRGKHAVVIGRSNIVGKPMALMLLAKDATVTVCHSRTADLKAQTLQADVIVAAVGRRNVLTADMVKPGAVVIDVGMNRNDEGRLCGDVDFDGVREVAGHITPVPGGVGPMTITMLLVNTLEAAERAAG
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
A1TPZ6
Q7V0G7
LNT_PROMP
Apolipoprotein N-acyltransferase
Prochlorococcus
MINTQNKKFNKYFVPCLGGIFGGIATSTHFWLLFMPLSLFILWSRSDKKLANFLWGFFFILVSHSWLYELHPLTWLGFSWISSLIISISILFGCSIIGGILVYLWGLLVKKILQKKEISNMNSLRLTIKVLLLSFAWGIGEFILSQTPLFWIGLGEGIVPGDLYLAGLARWIGASGLCVVQLTIGFWIYLIYEKWKRKYHFKKTFLFGLLILVILHFLGGLTNPIERNNDYPVALWQTNMPTREKTNFKNQFINDKLISAQKIALSNDAKLLITPEGTLNNNFNLNFKSKIRMLAGGFRNSKNGLRSSLLGYQIGDKTYSSFIDKHRLVPLGEKIPGFLNIFSRGLSAVGGIQPGSDSRFFKWKFTQPLAIAICYEITDGFKIRNAVKSGAELIISAANLDPYPRKLHYQFLSLARVRSIENKKDNIIISNTGPSGLISEEGKIIKLFDPNTEQNDVVNPNFSIEKTFYTTYGERPLFLLCLFLIGLNLYFGKFTN
Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.
Q7V0G7
P29386
AGL6_ARATH
Agamous-like MADS-box protein AGL6
Arabidopsis
MGRGRVEMKRIENKINRQVTFSKRRNGLLKKAYELSVLCDAEVALIIFSSRGKLYEFGSVGIESTIERYNRCYNCSLSNNKPEETTQSWCQEVTKLKSKYESLVRTNRNLLGEDLGEMGVKELQALERQLEAALTATRQRKTQVMMEEMEDLRKKERQLGDINKQLKIKFETEGHAFKTFQDLWANSAASVAGDPNNSEFPVEPSHPNVLDCNTEPFLQIGFQQHYYVQGEGSSVSKSNVAGETNFVQGWVL
Probable transcription factor. Forms a heterodimer via the K-box domain with AG, that could be involved in genes regulation during floral meristem development.
P29386
A8Q2H5
RSSA_BRUMA
40S ribosomal protein SA
Brugia
MSAGLETFALKEEDAIKLLACQTHVGAANCDFQMEQYVWKRRADGIHIIHLRKTWEKLLLAARAIAAIDNPGDVCVVSARPYAQRALLKFAAHTGSTPIFGRFTPGCLTNQIQKQFKEPRLLIVSDPRVDHQAVTEASYVGVPVISFCNTDSPLKFIDIAIPCNNKGVQSIGLMWWLLAREVLLIKGKMTRQTGFVLDDKEIMPDLYFYRNPEEQEKEELAEPREVKEPWPGVPPPEVAKIDEVVRSIGMYQTIGGVEPAKKLDFSMVEPVSDWAQETERAVQLDAAQQQEWGASTQNSNW
Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits.
A8Q2H5
P26572
MGAT1_HUMAN
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
Homo
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQDAEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRRCLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQGYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSAWNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLARVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIVTFQFRGRRVHLAPPLTWEGYDPSWN
Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
P26572
Q07UP2
MNME_RHOP5
tRNA modification GTPase MnmE
Rhodopseudomonas
MHASDQTIFALSSGRPPSAIAIVRVSGSRGAKIVEALAGRLPTPRMAMRALIKDRDGEPIDDAVVLWFPGPASATGEDVAEFHIHGGRAVLAALMATLSSFENVRAAEPGEFTRRAFEHGKIDLTEAEGLDDLIHADTDRQRRQALRQLNGLLGDRARDWRAQIIEAQALIEAGIDFADEGDVPDDLLAPALAKIEALAGEIEALLAAQGRSERLRDGLVVAIVGPPNVGKSTLMNQLARREVAIVSPHAGTTRDVIEVHLDLDGYPVTVIDTAGIRDSDDPVEQEGVRRAQARAAEADLVLWLLADDQVAAPAAIESDAPVWLVRNKVDLAGAATGVKPAKNLEANLGQNVPQPSFAISAKRGDGIADLVGALGGFAAEFFGAGEAGAITRQRHRDLLRDALVMLQCSKRGRAEELVAEDLRSASRSLGRLLGQVDVEDVLDALFRDFCIGK
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Q07UP2
Q30RQ5
MDH_SULDN
Malate dehydrogenase
Sulfurimonas
MNQGKRVGIIGAGNVGATVAYSLAMLGSCHEIILRDNKIDVAKGKALDMSQAAAAVRSHTIVSVAEEMADLTNCDVVVVTAGSPRLPGMSRDDLLMINANITKDVIAGVAKYSPDAIIIMVSNPLDAMTYVALKESGFDRSRVIGMAGILDSARMASFIQEKLGYGGGQIRASVMGGHGDDMVPLARYSTVAGVPLTDLMSTSEINEIVIRTRNGGAEIVGHLKTGSAYYAPAKATALMVEAILKDTKQIHPCAVFLEGEYGHSDVVSGVPVMLGANGAEKIIEISLDESEKIMFEGSCNSVRTLIDTLNKNKFFDKGE
Catalyzes the reversible oxidation of malate to oxaloacetate.
Q30RQ5
Q67FQ3
ARHB_XENLA
Autosomal recessive hypercholesterolemia protein homolog beta
Xenopus
MDALKSAGRAIIRSPSIAKQSWGGGKHKKLPENWTDTRETLLEGMLFHLKYLGMTLVEQPKGEELSATAVKRIVATAKASGKKLQKVLLKVSPRGIILYDSASNQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNETLECHAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSRENKDKREKSGSDGEGASSSQSDGSSSITSLKASASANLLDFEDCTKAFDVLNASDNHIEDLFRQNSTNENNNIVWELDDGLDEAFARLAESRTNPQVLDIGLTANDLQSEECLSPTSWDKLELNPAEADELFMF
Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR). Also involved in the vitellogenin receptor mediated endocytosis of nutrients during oogenesis.
Q67FQ3
Q31FG4
HLDD_HYDCU
ADP-L-glycero-beta-D-manno-heptose-6-epimerase
Hydrogenovibrio
MIVVTGGAGFIGSNIVKALNAQGRTDILVVDNLKNGKKFINIADCDIADYLDKEDFQSRIFAEEGLPDIDCVFHEGACSATTEWDGKYMMDNNYEYSKDLLNYCLNRKIPFLYASSAAVYGDGPTFIEERQYEKPLNVYGYSKFQFDQYVRRILPLAESQVAGFRYFNVYGPREQHKGDMASVAFKLHNQVLAGEKLKLFGAYDGYEAGMQTRDFVFIEDVVNVNLWFMENPEQSGIFNLGPAAAEPFKHIADAVIDFHGQGEIEYIPFPDRLKGAYQSFTQADNTRLRDAGYDKPFHTVSEGVQKYLRWLSDNPRVLDFTKK
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
Q31FG4
P59149
RR4_EXSCR
30S ribosomal protein S4, chloroplastic
Exsertotheca
MSRYRGPRVRIIRRLGTLPGLTNKTSQLKSSSINQSISNKKISQYRIRLEEKQKLRFHYGITERQLLNYVRIARKAKGSTGEVLLQLLEMRSDNVIFRLGMAPTIPGARQLVNHRHILVNDCIVDIPSYRCKPQDFITIKNQRKSETMISKNIELYQKSKIPNHLTYSSLEKKGLVNQILDRESIGLKINELLVVEYYSRQA
With S5 and S12 plays an important role in translational accuracy.
P59149
A5D145
MURG_PELTS
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Pelotomaculum
MRFLVSGGGTGGHIYPALAIARGLKNRYPGAEILYMGTSNGMEADIVPAEGFPFTGISASGLERKLSPRNLLALWQAVRGFCQAVEIIGRWRPEAVIGTGGYVCGPVVLAAVLKRIPTLIHEQNALPGVTNRILSRFASRVAITFADSLKYFPDQSKVRLTGLPVRPEILQADRKTGLQKLGIKEGRFFLLSFGGSRGARSINGAMLTVIKAFAGNPDVEILHATGKAGYQKFLDGCRAAGIELDKIGNVTVKEYIYNMQDALAAADLVVSRAGAATLAELTALGIPSILVPYPYASENHQEFNARALEKEGAALVILDRQLNGGLLSRTITELINDRARLQAMAAASRKMGKNRALEDIIDCIDELIRSKRRHF
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
A5D145
A6V8H8
ACEK_PSEA7
Isocitrate dehydrogenase kinase/phosphatase
Pseudomonas
MVQSAPASEIAALILRGFDAYREQFREITDGARARFEQAQWQEAQRASAQRINLYEEKVAETVAGLRAGLADSELLDVERWPIIKSAYIAQIDLRLDDELAETWFNSIFCGLFSHDNISDGTMFVHTTRPSLRAHARAPYTRTYRPGGDLRQALEKIFDDYRFDVPYDDRERDLERIDALLHSNLPDWVCKDPDLAIELIGSVFYRNKGAYLVGRLFTPDEQWPLVFPLLHREGHGIQFDTVITDEAEVSIIFSFTRSYFMVDVPVPAELVAFLKRLLPGKHLAELYTSIGFYKQGKSEFYRALINHLATTDDRFVMAPGVRGMVMSVFTLPGFNTVFKIIKDRFNPSKSVDHATVIQKYQLVKNHDRVGRLADTQQFADFRFPVSKFEPECLAELLEVAPSTVVVEGDVVLIRHCWTERRMTPLNIYLENASEAQTREALNDYGLAIKQLAAANIFPGDMLLKNFGVTRHGRVVFYDYDEICYLTEVNFRYIPEPRFPEDEMSSEPWYSVGPNDVFPEEFPRFLFVDLDQRRLFAKLHGNLYDAKYWQGLQQQIREGKVIDVFPYRRQETPEQLLK
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
A6V8H8
P71010
ALBB_BACSU
Antilisterial bacteriocin subtilosin biosynthesis protein AlbB
Bacillus
MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFGMRARKADSR
Involved in the production of the bacteriocin subtilosin. Required for maximal production and for optimal immunity to subtilosin.
P71010
B1WRN9
CCS1_CROS5
Cytochrome c biogenesis protein CcsB
Crocosphaera subtropica
MTISDSPQTPENLSLPKQGFRQLIKIVADLRLAIVLLLAIALFSISGTVIEQGETISFYQQNYPEDPALFGFLTWKVILILGLNHVYTTWWFLSLLVLFGTSLTTCTFTRQFPALKAARKWNFYQKARQFEKLALSTELAINDLKFVNNLLEQKGYKTFQENQAIYARKGIIGKIGPIVVHAAMLIILGGAIWGALTGFLAQAMVPTGSEFKVNNIIEAGPLSQPQIPKDWGIRVNRFWIDYTPDGTIDQFYSDLSVINNDGEELKHKTIYVNEPLRYHGVTFYQTDWGIAGVQAQVNNSPIFQLPMALLNTNGNGRIWGTWIPTKPDLSEGVSLLAKDLQGTMMVYDQKGDLYSAVRPGMILDINGVRLKIYQLIGSTGLQIKADPGIPFVYTGFGLLMMGVIMSYVSHSQIWVLQEDEHCYIGGKTNRSQVTFERELLGIIESLEPEKT
Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment.
B1WRN9
B7GYL4
MINC_ACIB3
Probable septum site-determining protein MinC
Acinetobacter calcoaceticus/baumannii complex
MADIRITGRMVNFSRITFDTNDHDVIRQQLSNILNEGSYQGTVVIIDSTVEQELIALIQLLVSLGLQPMAVIDGILGDEARAIQFPVLPADQPLQRIKPTAEQVAIVEKPSSAQASVETKKPLNNNAVAHITSYHDEILRTGQSLVQDQGDIILKAAMNSGSEVIASGNIHIYGTVRGRVIAGAGGHAAARIFCQSLEAELVSIAGTYCVADDIPKHVVKKPVHIYLNEKQELEFEALEL
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
B7GYL4
A5DBJ8
LOC1_PICGU
60S ribosomal subunit assembly/export protein LOC1
Meyerozyma
MATRQSKTAKRNKTQNQKRNVESEVFTDSAARNLLENQPKLTPKSKVKKPSKLAVKKQQAKVRLYGAKNGREYKESELQIPVLNKAVVPGVKAKKGKKGKVFVDDNDNLTMERLVKSINDKYDKVNESKLEKSRRLEEIREVKRREMEKKEEQKKNKLDDKKKELKNKASVARANRRKNAKEAAKEAESDEPRKKKVSFA
Required for efficient assembly and nuclear export of the 60S ribosomal subunit.
A5DBJ8
Q6FYM0
ATPD_BARQU
F-type ATPase subunit delta
Bartonella
MSDSFALIPLPLVDQRYAQALFDFVQEARSVENVEKAVASFLVVLDQHEDLKRFVQSPFFSIKEQIKVMRSVCENIKFADQGAGQILSNFLRVITVNRRLCALSGILQAFQHRVALSRREVSAQIISARPLSSHQEEELRVALEGVVRGKVLLHMCVDPTILGGLIIRLGSSQIDTSLVTKLSSLKLALKKEVS
This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.
Q6FYM0
P75052
TYPH_MYCPN
TdRPase
Mycoplasma
MNIVNLISKKQRGKALTETEINWFVHSVNNKSLADYQVSAFLMAVWFQGMNSKELFCLTKAMVKSGESLHFNHHSKLSVDKHSTGGIGDKVSIALIPILTALDYSVAKLSGRGLGYTGGTIDKLEAVGVKTDFTPTEAQNLLDQNDCFIIGQSEGIAPVDKVLYALRDTTATVDSLPLIASSVMSKKLAINNDYIFIDLKYGKGAFCKTKTMAKELAQYMYSIAKQFKRKLYIKLSDMNQVLGKTIGNALEVLEVVHFLKRNWTEVGADFIQLMEQIVTEILIETKRAPNKRAAVALYHATLEGEKPWQRFLKFIELQGSSWERFLDLKELFNPQYKAPVLASQSGTLSYTSPVDLAMVSISLGAGRMVKTDLIDPMAGIKLVKQANEVVKAGDTVLELYSSKPITPAHIEAAQHTIIIKQ
The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.
P75052
Q74CB9
PYRDB_GEOSL
null
Geobacter
MQKPDLSVEIAGITLRNPVMTASGTFGYGEEFSEYVNLEAIGAIITKGLSLKPKAGNPTPRIVETTGGMLNAIGLQNVGIDAFVEKKVPFLRTVATPVIVNFFGNTLEEYAELAERLDLIPEVAAVEINISCPNVKHGGIVFGTDPKAAYSVVKAVREATIKPVIVKLSPNVTDIVEMAWACADAEADALSLINTLTGMAIDLDKRRPILANVTGGLSGPAVKPIALRMVWQVARAVKIPVIGIGGIMTGIDALEFMLAGATAVQVGTANFLDPGAAGRIAAEMERYLADNGIADVKEMIGALEV
Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
Q74CB9
Q9LPK6
AEE9_ARATH
AMP-binding protein 9
Arabidopsis
MELLLPHPSNSTPLTVLGFLDRAASVYGDCPSILHTTNTVHTWSETHNRCLRIASALTSSSLGINRGQVVSVVGPNVPSVYELQFAVPMSGAILNNINPRLDAHALSVLLRHSESKLVFVDPNSISVVLEAVSFMRQNEKPHLVLLDDDQEDGSLSPSAASDFLDTYQGVMERGDSRFKWIRPQTEWQPMILNYTSGTTSSPKGVVLSHRAIFMLTVSSLLDWHFPNRPVYLWTLPMFHANGWGYTWGTAAVGATNVCTRRVDAPTIYDLIDKHHVTHMCAAPMVLNMLTNYPSRKPLKNPVQVMTAGAPPPAAIISRAETLGFNVGHGYGLTETGGPVVSCAWKAEWDHLDPLERARLKSRQGVRTIGFAEVDVRDPRTGKSVEHDGVSVGEIVLKGGSVMLGYYKDPEGTAACMREDGWFYSGDVGVIHEDGYLEVKDRSKDVIICGGENISSAEVETVLYTNPVVKEAAVVAKPDKMWGETPCAFVSLKYDSNGNGLVTEREIREFCKTRLPKYMVPRKVIFQEELPKTSTGKIQKFLLRQMAKSLP
May act as an acid--thiol ligase that activates carboxylic acids by forming acyl-CoAs.
Q9LPK6
D2Y2D6
H2A14_CYRHA
Peptide F8-20.15
Haplopelma
MKVTLIAIPTCAAVLVLHTTAAEELEESQLMEVGMPDTELAAVDEERLFECSVSCEIEKEGNKDCKKKKCKGGWKCKFNMCVKV
Postsynaptic neurotoxin.
D2Y2D6
Q9H6Q3
SLAP2_HUMAN
Src-like adapter protein 2
Homo
MGSLPSRRKSLPSPSLSSSVQGQGPVTMEAERSKATAVALGSFPAGGPAELSLRLGEPLTIVSEDGDWWTVLSEVSGREYNIPSVHVAKVSHGWLYEGLSREKAEELLLLPGNPGGAFLIRESQTRRGSYSLSVRLSRPASWDRIRHYRIHCLDNGWLYISPRLTFPSLQALVDHYSELADDICCLLKEPCVLQRAGPLPGKDIPLPVTVQRTPLNWKELDSSLLFSEAATGEESLLSEGLRESLSFYISLNDEAVSLDDA
Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.
Q9H6Q3
Q0P8W4
PSEB_CAMJE
UDP-GlcNAc-inverting 4,6-dehydratase
Campylobacter
MFNKKNILITGGTGSFGKTYTKVLLENYKPNKIIIYSRDELKQFEMASVFNAPCMRYFIGDVRDKERLSAAMRDVDFVIHAAAMKHVPIAEYNPMECIKTNIHGAQNVIDACFENGVKKCIALSTDKACNPVNLYGATKLASDKLFVAANNIAGNKQTRFGVTRYGNVVGSRGSVVPFFKKLISEGAKELPITDTRMTRFWISLEDGVKFVLSNFERMHGGEIFIPKIPSMKITDLAHALAPNLSHKIIGIRAGEKLHEIMISSDDSHLTYEFENYYAISPSIKFVDKDNDFSINALGEKGQKVKDGFSYSSDNNPLWASEKELLEIINHTEGF
Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose.
Q0P8W4
Q47F76
PSRP_DECAR
Pyruvate, water dikinase regulatory protein
Dechloromonas
MPTTIKRTVFFVSDGTGLTVEALGHSLMTQFEDIEFKQIRIPFLTSVEQAQEAVARINGQGESDGMRPIVFTTLVNPELSSIVHQADAFCLSYFDTFLAPLEAELGIKSNHTVGRSHGSAESSEYKKRIESINYTLAHDDGITDRDLEEADVILVAVSRCGKTPTSLYLAMQFGLKAANFPLIPEDFDRGRLPGTLEKHRSKLFGLTIQPERLHQIREERRAASNYASLANCRFEIAEAEKMMRREGIRWLDSSTKSIEEISTTILQELKLR
Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation.
Q47F76
Q754Q2
ACH1_ASHGO
Acetyl-CoA deacylase
Eremothecium
MTVSQLLKQRVRYAPYLSKVRRAEELLPLFKHGQYIGWSGFTGVGAPKVIPTALADHVEKNGLQGQLAFNLFVGASAGPEENRWADLDMILRRAPHQVGKPIARAINDGRIKFFDKHLSMFPQDLTYGYYTRERTDGKILDYAIVEATAIKEDGSIVLGPSVGGSPEFMSAADKLIVEVNTATPSFEGLHDIDMPVLPPHRVPYPYTRVDERSGLDAVPVDPARVVALVESTERDKVGPNTPSDEGSRAIAGHLVEFFENEVRHGRLPANLLPLQSGIGNIANAVIEGLAGASFRNLTVWTEVLQDSFLDLFENGSLEFATATSIRLTEAGFEKFFANWDEYSSKLCLRSQVVSNSPEMIRRLGVIAMNTPVEVDIYAHANSTNVSGSRMLNGLGGSADFLRNAKLSIMHAPSARPSKTDPTGISTIVPMASHVDQTEHDLDVLVTDQGLADLRGLCPRERAREIIRQCAHPDYKPILTDYLDRAEHYAQRSRSMHEPHILQQALRFHTHLAEKGTMKVPSWD
Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.
Q754Q2
Q49UQ2
RS18_STAS1
30S ribosomal protein S18
Staphylococcus
MAGGPRRGGRRRKKVCYFTANGITHIDYKDTELLKRFISERGKILPRRVTGTSAKYQRMLTLAIKRSRHMALLPYVKEEQ
Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.
Q49UQ2
Q755A2
KXD1_ASHGO
KxDL homolog
Eremothecium
MSDDVDSETRSRTPSISSRQFIIPEDELATLDSENSSLDSGGEEASSGGSDAYSAAGGSTPVFSRLGQHPSTFFTGSQVAPIFDTSLYLFESLTQSLDSVDFSEALSLQTKTSATINSKSRELQLLVGEVQTHLRRLQTAFEQGQHTAQRVRHNLRDITRGVESLKQTFARSYPIEYHQALERAYERRAE
Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
Q755A2
P51563
TCR7_VIBAN
Tetracycline resistance protein, class G
Vibrio
MRSSAIIALLIVGLDAMGLGLIMPVLPTLLRELVPAEQVAGHYGALLSLYALMQVVFAPMLGQLSDSYGRRPVLLASLAGAAVDYTIMASAPVLWVLYIGRLVSGVTGATGAVAASTIADSTGEGSRARWFGYMGACYGAGMIAGPALGGMLGGISAHAPFIAAALLNGFAFLLACIFLKETHHSHGGTGKPVRIKPFVLLRLDDALRGLGALFAVFFIIQLIGQVPAALWVIYGEDRFQWNTATVGLSLAAFGATHAIFQAFVTGPLSSRLGERRTLLFGMAADGTGFVLLAFATQGWMVFPILLLLAAGGVGMPALQAMLSNNVSSNKQGALQGTLTSLTNLSSIAGPLGFTALYSATAGAWNGWVWIVGAILYLICLPILRRPFATSLVI
Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter.
P51563
Q1GBK5
RS14Z_LACDA
30S ribosomal protein S14 type Z
Lactobacillus
MAKTSQKVRNHRPAKFSSREYTRCERCGRPHSVYRKFGLCRICLKELGHKGQIPGLKKASW
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
Q1GBK5
A0QJL0
DNLI_MYCA1
Polydeoxyribonucleotide synthase [ATP]
Mycobacterium avium complex (MAC)
MSPSHAKLATVLLFDVATASADVGGTPSRLTKVARIADLLRRAAPDAALVAIVVSWLSGELRQRQIGVGWAALRSRPPAAAHPTLTVVAVDAAFAEIGAVAGKGAQARRAALLNALFAAATETEQTFLLRLLGGELRQGALAGIMADAVARAAGIPAAAVQRAAMLGGDLPAVAAAALSGEAAALSGEASALDAFTLRVGRPVAPMLAQTAAGVAEAIERHGGQAIFEAKLDGARVQIHRAGDQVTVYTRSLDDVTARLPEVVTATLALPVEALIADGEAIALRPDNSPQRFQVTASRFGRSVDVAAAVAAQPLSVFFFDILHCDGVDLLDAPTTDRLAALDALVPPAQRVDQLLTADPDAAGRFLEATLAAGHEGVMAKAPGAPYQAGRRGAGWLKVKPVHTLDLVVLAVEWGSGRRRGKLSNIHLGARDPATGEFVMVGKTFKGMTDAMLDWQTARFTELAVGGTDGYVVRVRPEQVVEVAVDGVQKSSRYPGGLALRFARVLRYRDDKGPAEADTIDAVRALY
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
A0QJL0
B2UVE0
FABZ_HELPS
Beta-hydroxyacyl-ACP dehydratase
Helicobacter
MEQNHQNLQSQFFIEHILQILPHRYPMLLIDRVVELEANKKIVAYKNITFNEDVFNGHFPDKPIFPGVLIVEGMAQTGGFLAFTSLWGFDPEIAKTKIVYFMTIDKVKFRIPVTPGDRLEYHLEVLKHKGMIWQVGGTAQVDGKVVAEAELKAMIAERD
Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
B2UVE0
Q3AQ12
ACP_CHLCH
Acyl carrier protein
Chlorobium
MTAAEIKDKVFDIIVSRMGVNKDQIKMESKFSDDLGADSLDTVELIMELENAFDVQIPDEDAEKIATVQQAVDYIVSKQ
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Q3AQ12
A8F4Q8
EFG_PSELT
Elongation factor G
Pseudothermotoga
MLEIEALYVPLSKLRNIGIMAHIDAGKTTTTERILYYTGRKHVLGSVDEGTATMDWMEQEKERGITIKAAATTCFWKEHRINIIDTPGHVDFTVEVERALRVLDGAVAVFDATAGVEPQSETVWRQAERYSVPRIAFMNKMDKTGADFFMSIKSMVEKLHAKPVAIQVPIGAEKDFIGVVDLIEMKAITWTSEDGSEFIKHEIPENMLDLAEEMREEMISMLAEEDEELLELYLEEQELPVEKIKDILRKATINNKLVPVLCGAAARNKGIQPLLDAVVDYLPSPIDIPAVKAITPSGEEIQIPPSVEGDFAGLAFKIQTDPYVGKLAYVRVYSGKLEKGSYVYNSTKQIRERVARLIFMHADKREDAEYARAGDIVAIIGLKNTTTGDTLCSQERPVLLEKMSFPEPVISIAIEPLTRDDEERMVKAVAALSEEDPTLRINVDRETGQVVLSGMGELHLEIVTDRLKREFGVNVRVGRPQVSYRETIRQTGTAEGKYVRQTGGRGQYGHVIMKFEPLPLDGEKQFEFINKTVGGVIPREYIPAIEEGVKEAMEMGVLAGYPMIGVRAVLLDGSYHEVDSSEIAFKVAASLAFKNAMKICQPVLLEPVMKLEVVVPEEYVGGIIADLNARRAQIESLESRINLRVIKAFVPLSELFGYATTLRSLSQGRAVHVAQFSHYKEAPDKVVEKVLKVV
Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
A8F4Q8
Q2FZL3
SSPB_STAA8
Staphylopain B
Staphylococcus
MNSSCKSRVFNIISIIMVSMLILSLGAFANNNKAKADSHSKQLEINVKSDKVPQKVKDLAQQQFAGYAKALDKQSNAKTGKYELGEAFKIYKFNGEEDNSYYYPVIKDGKIVYTLTLSPKNKDDLNKSKEDMNYSVKISNFIAKDLDQIKDKNSNITVLTDEKGFYFEEDGKVRLVKATPLPGNVKEKESAKTVSAKLKQELKNTVTPTKVEENEAIQEDQVQYENTLKNFKIREQQFDNSWCAGFSMAALLNATKNTDTYNAHDIMRTLYPEVSEQDLPNCATFPNQMIEYGKSQGRDIHYQEGVPSYEQVDQLTKDNVGIMILAQSVSQNPNDPHLGHALAVVGNAKINDQEKLIYWNPWDTELSIQDADSSLLHLSFNRDYNWYGSMIGY
Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S.aureus by neutrophils and monocytes by inducing their death in a proteolytic activity-dependent manner. Decreases surface expression of the 'don't eat me' signal CD31 on neutrophils. Cleaves host galectin-3/LGALS3, thereby inhibiting the neutrophil-activating ability of the lectin.
Q2FZL3
B0SCK5
LPXD_LEPBA
UDP-3-O-acylglucosamine N-acyltransferase
Leptospira
MTQIKLSTLQTLLPDATFQNSETLKDINFSGLTSLTLAGPSDISFVASKTFVNEAKASKASLLVVSQETAEALSDKAIIIVSKVELTTAKIIRLFFPEKQPSGKRSAQVAIDPSAKIGSNTDIGHFVTIGKDSIIGNDCIIEDGVKIGDRVQIGDGARIGKNCVFFDDTIVGKRFIAFGNSTFGGDGFGFVYAEGKHNKIPQVGRVVIGDDVEVGSNCTIDRGALTDTTIGNGCKFDNMVHVAHNCKVGDHVIIAGQSGLAGSVTLGNNVIIGGACAISDHLTLVDGTIIAGGSSLRTSPKTKDVYVGWDLGLTFPEFQKYRVNIKNIVNLNKWLKRIENIEKKVGIETKES
Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
B0SCK5
A8MLM7
SPED_ALKOO
S-adenosylmethionine decarboxylase alpha chain
Alkaliphilus
MLGLEKKLTLYGFNNLTKTLSFNIYDVCYAKSEKAQKAYIEYIDEQYNSERLTKILCDVTEMIGAHVLNISKQDYEPQGASVNILITEEALPLHLIDESCNKGEGIAAQRDTIHAHLDKSHVTVHTYPEYHPDNAISTFRVDIDVSTCGMISPLNALDYLIGSFDSDIITIDYRVRGFTRDVEGKKFYIDHNITSIQDYIDDETLKKYDAIDVNVYQSNIFHTKMLIKEIELQNYLFNKDVNELLPKQRLEITNNLRKEMIEIFSGMNIY
Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.
A8MLM7
C3N5U6
RL18_SULIA
50S ribosomal protein L18
Sulfolobus
MANGPNYKIKPRRRREGKTNYYKRYVYVISKQIRFIVRITNKYVIVQIAKIDPKGDIMVASAHSSELTKKFEWKGDENNTPSAYLTGYLAALRAVKKGVTECVADIGLHVPSKGNKVFYAIKGAIDAGLKIPIGDISIENDRIKGEHIAKYAEKLKSENLDLYNKLFSRYLGRGLNPENLPSHFEEILNKIKSSGG
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
C3N5U6
B1J143
LIPB_PSEPW
Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase
Pseudomonas
MSLCLGFRELGLQPYEPVLEAMRRFTEQRSPDSQDEIWLVEHPAVFTQGQAGKAEHLLVPGDIPVVQTDRGGQVTYHGPGQLVAYLLLDVRRLGFGVRELVSRIEQTLIELLASYGVSAAAKPDAPGVYVDGAKIASLGLRIRNGRSFHGLALNVDMDLAPFRRINPCGYAGLAMTQLRDLAGPIELDEVRTRLRGQLVKHLDYAEQTTLTGGID
Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
B1J143
P53608
ARGI_BACCD
Arginase
Geobacillus thermoleovorans group
MKPISIIGVPMDLGQTRRGVDMGPSAMRYAGVIERLERLHYDIEDLGDIPIGKAERLHEQGDSRLRNLKAVAEANEKLAAAVDQVVQRGRFPLVLGGDHSIAIGTLAGVAKHYERLGVIWYDAHGDVNTAETSPSGNIHGMPLAASLGFGHPALTQIGGYSPKIKPEHVVLIGVRSLDEGEKKFIREKGIKIYTMHEVDRLGMTRVMEETIAYLKERTDGVHLSLDLDGLDPSDAPGVGTPVIGGLTYRESHLAMEMLAEAQIITSAEFVEVNPILDERNKTASVAVALMGSLFGEKLM
Controls arginine catabolism.
P53608