accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
C6DYS1
YIDC_GEOSM
Membrane protein YidC
unclassified Geobacter
MEKRLIIAVVLSIGVLYAYSFIFPTPKPVPTPGGKQAAMSSATAPAPSVAALPIAGTTPVAAPAPQAGQAPAVAKDVTVDTDLYTAVFSTQGGGLKKFVLKKYKETAGPQGKDIVLVNETAANRYALLSDSREFGISPNALYSASTGEVKVTDGGKGSLELTTTTSQGITFRKVYTFSGDAYRIGLTEEVQNVGNVALTGAVHLLQTSRVVDAKKEGRYEVYSPSTLAEGKVKLDDLEDLQKTPVQYGKDIAWSAFADKYFVDGIIADKGSISQVRITRPANDAILRDVASPTVSVAPGQRSAINYAIYYGPKDLDILKL...
Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning memb...
C6DYS1
Q4QPI7
UVRC_HAEI8
Excinuclease ABC subunit C
Haemophilus
MFDAKKFLADVSHEPGVYRMYDDKDQVIYVGKAKDLKKRLSSYFRKNLSSKKTEALVASIHHIDTMLTSSETEALLLEHNFIKLYQPRYNVLLRDDKSYPFILLTKERHPRITSYRGSKKFAGEYFGPYPHAGAVRETLSLLQKLFPVRQCENSVYSNRSRPCLQYQIGRCSAPCVQGYVSDEEYNQQVELARLFLQGKDQQVLDYLIGKMEQASRNLDFEQAARYRDQIQAVRSVIEKQFVSNERLDDMDIMSIAYQHGLACVQVMFIRQGKVLGNRSYFPKVPANTDLSELTETFVGQFYLQGHQGRSIPNSIIVDRQ...
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q4QPI7
Q755J9
VPS27_ASHGO
Vacuolar protein sorting-associated protein 27
Eremothecium
MNTEIQTVAALGECIQRATSESIPNGEIDLALALDVSDAVRSRRLGARDSMRALKKRVLQTKSNPNTQLAAWRLVEVCVKNGGTHFLKEVCSREFMDCMEHVAAQEKTVDNEDLVQLCRRIIFELYTAFKNDSQLSYVSQVHQRLQARGVEFPQAAPGYLVNTMAMFDSKAPADWVDSDACMICSNAFTFLNRKHHCRSCGGIFCNEHSSHQLPLPEMGITEPVRVCDNCYDEYEIKKHSSRRLRRQSQRRARPKAEREDEDDDLRRAIELSLRESKTQDNLVPTVTRLENSDATKDDEDPEFLAAVQASLREHQLEQER...
Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.
Q755J9
P45125
UVRB_HAEIN
Excinuclease ABC subunit B
Haemophilus
MSEKINTKPFILHSDFRPSGDQPQAIEKLAENLTDGLAHQTLLGVTGSGKTFTIANVIAQLNRPAMLLAPNKTLAAQLYAEMKAFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASINDQIEQMRLSATKSFLERRDTIVVASVSAIYGLGDPDSYLQMMLHLQQGAIIDQRQILAKLAELQYTRNDQAFQRGTFRVRGEIIDIFPAESDDRAVRIELFDDEIERLSLFDPLTGSSFGAVPRFTIYPKTHYVTPRERILDAIENIKKELVSRREYFIKEHKLLEEQRISQRTQFDIEMMNELGYCSGIENYSRYLSG...
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP bindi...
P45125
Q97CP8
VATD_THEVO
V-ATPase subunit D
Thermoplasma
MEIRPTRIELIRTRRRIKLARKGLDLLKMKRSALIYEFLQISRTIRGMRENLRREVEDALNTIRTAEILEGQVALERIANMSSDSTINVDSRNVMGVVIPTLNLTYNLSILSDVYRTISVPVAINDAIDRFQRLFLNLIQILEKENALRNLLIEIDKTKRRSNAIENILIPRLEYQAKMIKMMLDERERDTFTTLKTIKKKIEAGKDEE
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Q97CP8
B9DM01
XPT_STACT
Xanthine phosphoribosyltransferase
Staphylococcus
MEALRQKVKEDGVVIGEKILKVDGFLNHQIDAQLMYDIGETFYEQFKDQKVTKILTVEASGIAPAIMVAYKFGVPCLFAKKAKPNTLNKGFYQTDIHSFTKDKTNSVIISEEFLDEHDRVLIIDDFLANGDASLGLNRLVHQAGAETVGVGIVVEKSFQQGRTRLEEAGLKVSSLCEVASLSGNKVTLVGEE
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
B9DM01
Q9K9G7
THIZ_HALH5
Formylaminopyrimidine import ATP-binding protein ThiZ
Halalkalibacterium (ex Joshi et al. 2022)
MVKELLTFEEVSFAYSSSSPVIERLSFTVFENEIVAILAKSGSGKSTLFRLITRLESPDQGTIVCHAQGKIGYMPQQDLLLPWLTILENVSLPLEIQGKDKKEAKIIAASFFNRFGLVGTESLYPDALSGGMRQRAAFLRATLTSETLLLLDEPFASLDSLTKTSMHHWLVSMWEKEKRTLLLVTHDIEEALLLSDRLFIFTNQPLHGFTEVQVPPDLRRKMETTEKMEQQRSSLKKDIRALLIEESLR
Participates in a thiamine pyrimidine salvage pathway as part of the ABC transporter complex ThiXYZ involved in the import of thiamine degradation products such as the formylaminopyrimidine N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine (FAMP). Is likely responsible for energy coupling to the transport system.
Q9K9G7
S7UQV8
UGO_TOXGG
Unique GC organizer UGO
Toxoplasma
MRMQWFLLRHAYFIKGEDFAVAVALLDLALYVLIGTNSLQFLDQSPEKALFGMITSALIFIIALCGFVIVRMFRTSKYKIETYIMPVLIICNIASVFYMQLINKLVGFMTLQLPVLTFLITGYPYVWLVAFVLIGMGGGLIAQSVVCSVSLGSSCPPSVWVDVGLYALQLISGSVAYFTVYELGILIVRYKRHPARYLDAFSDLTALDTIVFSPVFGLGGETARQVQVNQLMAPEKPNLDGLTFLRSASQVSQTTNRIVSRAFYHANTPPHSSSRDALPADKALGAERSDRAGSAVFSPNTLGPLGAPSAGLRDFGPGRP...
In tachyzoites, required for the cellular trafficking of guanylate cyclase GC to the cell membrane and for GC guanylate cyclase activity.
S7UQV8
Q5HR05
Y390_STAEQ
Putative lipid kinase SERP0390
Staphylococcus
MKQPYNHGVLFYHEHSGLKDIHNGIGEVAKSLSSMCKHLSLQLSENKGDIIKYCKSIKNENYSSDVDVLFILGGDGTLNELVNGVMQYQLNLPIGVIPGGTFNDFTKTLQLHPNFKTASEQLLTSHAESYDVLKVNDLYVLNFVGLGLIVQNAENVQDGSKDIFGKFSYIGSTVKTLLNPVKFDFSLTVDGETKEGNTSMMLIANGPNIGGGQIPLTDLSPQDGRANTFVFNDQTLNILNDILKKRDSMNWNEITQGIDHISGKHITLSTNPSMKVDIDGEINLETPIEIQVLPKAIQLLTATEQNN
May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG).
Q5HR05
B0CA92
YCF3_ACAM1
Photosystem I assembly protein Ycf3
Acaryochloris
MPSDNFIDKAFSAMSDVVMKVIPTDQKSKDAFKYYRSGMAAQVDGNYAKALGNYTEALALEEDPFDKSYILYNMGLIFANNGDHEKALDYYHQSLELNPNLVQALYNTGVILHYKGEQAEEAAELDEAERFFDLAADFWKRAIKIAPNNYSEVQNWLKTTGRVGVG
Essential for the assembly of the photosystem I (PSI) complex. May act as a chaperone-like factor to guide the assembly of the PSI subunits.
B0CA92
A1L167
U2QL1_HUMAN
E2Q-like ubiquitin-conjugating enzyme 1
Homo
MKELQDIARLSDRFISVELVDESLFDWNVKLHQVDKDSVLWQDMKETNTEFILLNLTFPDNFPFSPPFMRVLSPRLENGYVLDGGAICMELLTPRGWSSAYTVEAVMRQFAASLVKGQGRICRKAGKSKKSFSRKEAEATFKSLVKTHEKYGWVTPPVSDG
Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins. May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7.
A1L167
C5BYK3
TILS_BEUC1
tRNA(Ile)-lysidine synthetase
Beutenbergia
MSGPHPSVAAARNAVRALLAELEPARGVLVACSGGADSLALAAATAFVAPRAGRAAGAVVVDHALQAGSAEVAARAADQCRGLGLEARVVRVDVDIALGGPEGAARAARYAALEAASREAGDAVVLLGHTLDDQAETVLLRLARGSGARSLAGMPRRRGVFARPFLHLERARLREVVDAVGLTPWEDPTNAVDGPARRADGGPLPRSAIRGRVLPALTEALGPGVPASLARSADLLREDADALDAFAADLLSTARGEDGSLDVEILAAAPPAVRRRALRRAALDAGSPAGDLAHVHVEALDALVTGYHGQAGVDLPGGRR...
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
C5BYK3
P45359
THLA_CLOAB
CaTHL
Clostridium
MKEVVIASAVRTAIGSYGKSLKDVPAVDLGATAIKEAVKKAGIKPEDVNEVILGNVLQAGLGQNPARQASFKAGLPVEIPAMTINKVCGSGLRTVSLAAQIIKAGDADVIIAGGMENMSRAPYLANNARWGYRMGNAKFVDEMITDGLWDAFNDYHMGITAENIAERWNISREEQDEFALASQKKAEEAIKSGQFKDEIVPVVIKGRKGETVVDTDEHPRFGSTIEGLAKLKPAFKKDGTVTAGNASGLNDCAAVLVIMSAEKAKELGVKPLAKIVSYGSAGVDPAIMGYGPFYATKAAIEKAGWTVDELDLIESNEAFA...
Catalyzes the condensation of two molecules of acetyl-CoA to produce acetoacetyl-CoA . Involved in solvent production .
P45359
B7JN72
THIE_BACC0
Thiamine-phosphate pyrophosphorylase
Bacillus cereus group
MSRISKAEMSKLLSVYFIMGSNNCTKDPLQVLREALEGGITIFQFREKGEGALTGEERICFAKELQAICKEYGVPFIVNDDVELALELDADGVHVGQDDEGITSVREKMGDKIVGVSTHTIEEARWAIENGADYLGVGPIFPTSTKKDTKAVQGTKGLAHFREQGITIPIVGIGGISIENTASVIEAGADGVSVISAISLAESAYESTKKLVEEVSRSL
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
B7JN72
Q4KJA1
THIC_PSEF5
Thiamine biosynthesis protein ThiC
Pseudomonas
MTTKLKNASNLSESAQVDQQSVQPFTRSQKVYVQGSRPDIRVPMREITLDVTPTDFGGEINAPVTVYDTSGPYTDPNVVIDVRKGLGDVRSAWIEDRGDTERLAGLSSNFGQQRLADPELTKLRFAHVNNPRRAKAGANVSQMHYARKGIITAEMEYVAIRENMKLQEARAAGLLKQQHAGHSFGASIPKEITPEFVREEIARGRAIIPANINHVELEPMIIGRNFLVKINGNIGNSALGSSIEEEVAKLTWGIRWGSDTVMDLSTGKHIHETREWIIRNSPVPIGTVPIYQALEKVNGVAEDLTWELFRDTLIEQAEQG...
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
Q4KJA1
P21798
TNNC2_BALNU
Troponin C, isoform 2
Balanus
MMDELDKDQIAMLKKAFDGFDHEKKGAINCDVVATILRMMGQAYNAQTLKELIDEVDADGSGMLEFEEFVTLAAKFIIDDDAEAMAKELKEAFRLYDKAGKGYIPTSALKDILKELDETLNAEDLDNIIGEIDTDGSGTVDFDEFMEMMTG
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
P21798
Q8Y832
TARI_LISMO
Ribitol-5-phosphate cytidylyltransferase
Listeria
MIYAEILAGGKGTRMGNVNMPKQYLPLKGKPIIVHTIEKFILNDRFEKIIIATPKDWINHTQDIIKKYIFDSRVIVIEGGTDRNETIMNGIRYVEKEFGLNEDDIIVTHDAVRPFITHRIIEENIDMALEFGSVDTVIPAVDTIVESTNHDFITDIPVRGNIYQGQTPQSFNMKTIQKHYNNLTDDEKQILTDACKICLLAGEKVKLVNGGISNIKITTPYDLKVANAIVQERINS
Catalyzes the transfer of the cytidylyl group of CTP to D-ribitol 5-phosphate.
Q8Y832
Q73H71
TSAD_WOLPM
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
unclassified Wolbachia
MKTILAVETSCDETAVAIVNSDKQVLAHEILSQAEHKKRGGVIPEIASRAHMEHLSGLIKSAVEKSNLNFCDLNAIAATSGPGLIGGLIVGTMMAKAIAHVAQKPFIAVNHLEAHALVIRLLHEVKFPFLVLLISGGHCQFLIAQDVGKYIKLGETLDDSLGEAFDKVAKMLGLSYPGGPLIEKLAKKGNGTRFKLPRAMIKRSGCNFSFSGIKTAVKNLVQELKMSEQDVCDVCASFQECISDILLDRVSNAIIMAESLNIKINDFVITGGVAANNFLREKLKQHINLNIFFPPNDLCTDNAIMVGWTGIERLQKNYID...
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct ca...
Q73H71
Q3KKY7
TIG_CHLTA
PPIase
Chlamydia
MSSRDFSNDLFSINIEENAGCVVSAKVQANPLVTQKCHKEALKTVKKNVVLPGFRKGKAPDNIVESRYSTQVEQELRRLFLRASFEALSQMCDRKPLSPKAVRSSAIDTCNPVNGGSVSFLYEAFPVIPSLPWEQLSLPDPEPVKEISEEDLENGLKNVAYFFATKTPVTRPSQEGDFISLSLYVSKRGDENSTPVAIFENKYFKISEEDMTDSFKARFLNVSTGHRVEEEIGSEDIQSFLNGDLLTFTVNAVIEISSPEMDDEKARQLQAESLEDLKKKLRIQLENQAKEAQHQKRFSDAEDALAQLIDFDLPESLLQE...
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Q3KKY7
Q67ES1
TR113_RAT
Taste receptor type 2 member 30
Rattus
MVAVLQSTFAIIFSMEFIVGTLGNGFIILMTCIDWVRRRKISLVDQILTALAITRITLILLVFIDWWVSVLFPALHETGKILRMYFISWTVINHCNLWLTASLSIIYFLKIASFSSIIFLYLKFRVKNVVFVTLLVSLFFLFINTAIVNVYFDVCFDGVQRNVSQVSRLYNHEQICKFLSFTNPMFAFIPFVTSMATFFLLIFSLWRHLKNMKHNAEGCRDVSTIVHIRALQTIIVSVVLYSTFFLSFFVKVWSSGSPERYLIFLFVWALGNAVLPAHTFVLIWGNCRLRWASLSLMLWLRYRFKNIDV
Putative taste receptor which may play a role in the perception of bitterness.
Q67ES1
Q9PG67
TSAD_XYLFA
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Xylella
MKIIGIESSCDETGVAVYDTALSGFAALRAHSVYSQVALHAEYGGVVPELASRDHVRKLLPLLRQTLAEAKLSVEELDGVAYTAGPGLVGALLVGAGVARALAWALEVPAIGVHHMEGHLLSPLLEDDPPEVPFVALLVSGGHTQLVAVDAIGDYRLLGETLDDAAGEAFDKVAKLMGLPYPGGPQLAALAEQGIPGRFCFTRPMVDRPGLDFSFSGLKTQVLLAWRNSDQSDAIRVDVARGFEDAVVDTLAIKCERALDTVACQTLVVAGGVGANKCLRARLQAMCRQRGGRACFPRPALCTDNGAMIAFAGALRLQAG...
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct ca...
Q9PG67
B5F7D6
YDIB_SALA4
NAD-dependent shikimate 5-dehydrogenase
Salmonella
MDVTAKYELIGLMAYPIRHSLSPEMQNKALEKAGLPYTYMAFEVDNTTFASAIEGLKALKMRGTGVSMPNKQLACEYVDELTPAAKLVGAINTIVNDDGYLRGYNTDGTGHIRAIKESGFDIRGKTMVLLGAGGAATAIGAQAAIEGIKEIKLFNRKDDFFEKAVAFAKRVNENTDCVVTVTDLADQHAFTEALASADILTNGTKVGMKPLENESLIGDVSLLRPELLVTECVYNPHMTKLLQQAQQAGCKTIDGYGMLLWQGAEQFELWTGKAFPLDYVKQVMGFTA
The actual biological function of YdiB remains unclear, nor is it known whether 3-dehydroshikimate or quinate represents the natural substrate. Catalyzes the reversible NAD-dependent reduction of both 3-dehydroshikimate (DHSA) and 3-dehydroquinate to yield shikimate (SA) and quinate, respectively. It can use both NAD o...
B5F7D6
A4WB03
TRPA_ENT38
Tryptophan synthase alpha chain
Enterobacter
MERYDNAFTELKARKEGAFVPFVTLGDPGPEQSLKIIDTLIAAGADALELGIPFSDPLADGPTIQSATLRAFASGVTPTQCFEMLATVRQKYPTIPIGLLMYANLVFNRGIDEFYAECARVGVDSVLIADVPIEESAPFRQAAMRHNIAPIFICPPNADDELLRQIASHGRGYTYLLSRAGVTGAENKAAVPLHHLVEKLAEYHAAPPLQGFGISSPEQVTAAIEANAAGAISGSAIVKIIEKNVDKPDQMLTELRDFVTVMKAATRHA
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
A4WB03
A7H4T0
THIC_CAMJD
Thiamine biosynthesis protein ThiC
Campylobacter
MKTQMNYAKEGVFTKEMQIVAQKENLSKDFLLENIACGKIIIPANINHKSLDPNGIGFGLRTKVNVNLGVSNDCVDYSEEMKKVELAHKFGIEAIMDLSNYGKTSRFRDELVNVSKAMIGTVPVYDAVGFLEKDLKQIGAKDFLDVVYHHAKSGVDFMTIHAGINSRATHIFKQSKRLTNIVSRGGSVLYAWMMMKDAENPFFEYYDDLLDICLKYDVTLSLGDALRPGSTHDASDGAQISELIELSLLTQRAWDVGVQVMIEGPGHMAINEIEANMQLEKRLCKGAPFYVLGPLVTDIGAGYDHISGAIGGAVAAASGA...
Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.
A7H4T0
P18726
ZG5A_XENLA
Gastrula zinc finger protein XlCGF51.1A
Xenopus
TGEKPFSCSDCGARFTYRSLLRRHNKIHAEGKSLICSECGKPFTSESALTAHQRSHGGEKPFSCTDCEKCFAQRMHLIEHQRTHTGEKPFSCTVCGEMFTYRAQFSKHMLKHKRKRTEGESLDCSHCGKHFTSRSDLTVHRKSHKGKSPLQCSDCGKCFKYQSQLASHQRVH
May be involved in transcriptional regulation.
P18726
Q255B1
TRMD_CHLFF
tRNA [GM37] methyltransferase
Chlamydia
MEIDILSLFPDYFDSPLRSSILGRAIKNGLLKIQSRDIREFGLGKWKQVDDAPFNNDGMLLMAEPVVQAIRYVKRRESRVIHLSPQGVPLTAQKSRELAKCSHLIFLCGHYEGIDERALEIEVDEEISIGDYVLTNGGIAALVVIDALSRFIPGVLGNQESAEKDSLENGLLEGPQYTRPRVFEGREVPQVLLQGDHQAIARWRKQVSLDRTRERRPDLYVRYLYDRESEDVPQMEADPKQSAFEGECAVVLDVENINRSKRFYSKVFKSNQPIGDKLYIPGKTQMVLHLQEVGLKNKNTAVLSLRLDCENDFYSFLGRW...
Specifically methylates guanosine-37 in various tRNAs.
Q255B1
C5CQK5
TATA_VARPS
Sec-independent protein translocase protein TatA
Variovorax
MGSFSIWHWLIVLLVVVMIFGTKKLRNMGSDLGGAVKGFKDGMKDGSTTDAPAASSAPAAQVTGQPANSDKSTIDVEARQKS
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
C5CQK5
Q9RPX3
YU58_BRUSU
Type IV secretion system putative outer membrane lipoprotein BRA0058/BS1330_II0058
Brucella
MRTLVMVACAVSLAACSSPPKPPTVSGRHRIPINSPAAQEELRLQVFPQEPTAQATMWPARPPKQTVSVYFPQDVTVFRPTSAQINQLHTLLWPVPKHINVRGLTDNNCPPPGDTQVARVRALAIYNWLINQGVSASRITISYAPVKDYASNAPLSPGRVLNRRVDIEILRK
The VirB system could be required for the establishment of the replication niche in the host.
Q9RPX3
Q5FC64
ZDHCS_CAEEL
Defective spermatogenesis protein 10
Caenorhabditis
MSWYSKIYVAVREYRAKHKITGWILTRCLNVLLFIQLILLWWSLYMYVTVTIGYYVQSTIQATIYLIVGSFLFVMSMWSLAKTLFTRVGRVPERYRPSKELEDRLKAVTPMEKNRYVVEKSTPEQLAQQNTILEEMCTYCKVVVAECDQVGRLKYCYECGHIKPDRARHCSSCGKCCIKYDHHCPWINMCVTHVNYKYFLLYIIYTSFLVYWYLLTSLEGAVRYFINQQWTDELGKFLFYLFSFIVGGVFGYYPLGELIIFHYQLISLNETTVEQTKPALLRFDNAADYNMGKYNNFQSVFGWGLWLCPIDSSTQDGLHF...
Involved in spermatogenesis, specifically in the morphogenesis of fibrous body-membranous organelles (FB-MO), which are Golgi-derived organelles used for transporting sperm-specific components, in spermatocytes and in their localization into budding spermatids . Required for the proper formation of spermatids and sperm...
Q5FC64
Q02115
TAGU_BACSU
Membrane-bound protein LytR
Bacillus
MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVASIHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMVSIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVVDTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVIQGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGTGTKINGIYYYQADESALSDITKELKESLEK
May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG).
Q02115
P76499
YFCP_ECOLI
Uncharacterized fimbrial-like protein YfcP
Escherichia
MNKSMIQSGGYVLLAGLILAMSSTLFAADNNLHFSGNLLSKSCALVVDGQYLAEVRFPTVSRQDLNVAGQSARVPVVFKLKDCKGPAGYNVKVTLTGVEDSEQPGFLALDTSSTAQGVGIGMEKTDGMQVAINNTNGATFALTNGNNDINFRAWLQAKSGRDVTIGEFTASLTATFEYI
Part of the yfcOPQRSUV fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches. Increases adhesion to eukaryotic T24 bladder epithelial cells in the absence of fim genes.
P76499
A9KYL6
UBIB_SHEB9
Ubiquinone biosynthesis protein UbiB
Shewanella
MTLASIRRGYHVIKTLLQYGLDDVLPPKMTPWYFKLARNSLFWIRNKHKNKPGGERLKLAMQELGPVYIKLGQMLSTRRDLLSDEWASELAMLQDKVPPFDGALARQAIEAELKAPIESLFDDFNETPLASASISQVHTATLKSNGKDVVLKVLRPNVETKIQADLQLMSQTAKLIEYLLGEGNRLRPAEVIEDYRVTILGELNLKLEALNAVKLRNNFLDSDALYVPYVYEEFCYPRLMVMERIYGISVSDIAALKAQGTNFKLLAERGVELFFTQVFRDNFFHADMHPGNIFISRDHPENPYYIGLDCGIMGTLSEVD...
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
A9KYL6
P84017
TX24_PHONI
Neurotoxin PNTx24A0C3
Phoneutria
VFCRFNGQQCTSDGQCCYGKCRTAFMGKICM
Acts as a neurotoxin.
P84017
B2KIQ4
WDR76_RHIFE
WD repeat-containing protein 76
Rhinolophus
MSGSCAAAEEKEGSRQRLQMKVNEYKENQNMSSVSLRSIQKTVLEKTVKVCLVPFSLSNYKSGQFKLPKSLLDKNSKNEVACKKYKKTEIKKACTRILTSKMEATASSKAESTLQKSSIDVHTENNQRQHKSTSDTVSLGVDTESSQDGDSDEDTTSSLDDFSGLSPYERKRLKNISENANFFASLQLSESAARLREMIEKRQPPETKRKKPKKKENETGCRRSMRLLNVDPSGVSLPVTPTEPTLVADENPLLPPGPLEMIPENRDDNSELFKEFLQTWAEVSKTSSKNIEKELSSLKTYKANLSGMVISEDTVYKVTK...
Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC.
B2KIQ4
Q182C6
YBEY_CLOD6
Endoribonuclease YbeY
Clostridioides
MDLILDDRQDKLEVSEELIEKIKDIIIECLDYEGYDDNYEVSLSFVDNKEIHELNREYRGVDRVTDVLSFPLLSDDFEDVELEEESLGDIVVSLERALEQSIEYNHSFEREVCFLICHSMFHLLGYDHDTDENTKEMREKEEHILNKLNITRE
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q182C6
Q9HM64
VATB_THEAC
V-ATPase subunit B
Thermoplasma
MPKLAYKSVSQISGPLLFVENVPNAAYNEMVDIELENGETRQGQVLDTRKGLAIVQIFGATTGIGTQGTTVKFRGETARLPISEDMLGRVFNGIGEPIDGGPEIIAKERMEITSNAINPYSREEPSEFIETGISAIDGMNTLVRGQKLPIFSGSGLPHNQLAAQIARQAKVLDSSENFAVVFGAMGITSEEANYFTNQFRETGALSRSVMFLNLSSDPSMERIILPRIALTTAEYLAFQKGMHILVILTDMTNYCEALREISAAREEVPGRRGYPGYMYTDLSTIYERAGKLKGNNGSITQIPILTMPGDDITHPVPDLT...
Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.
Q9HM64
B7LY16
TRPA_ECO8A
Tryptophan synthase alpha chain
Escherichia
MERYESLFAQLKERKEGAFVPFVTLGDPGIEQSLKIIDTLIEAGADALELGIPFSDPLADGPTIQNATLRAFAAGVTPAQCFEMLALIRQKHPTIPIGLLMYANLVFNKGIDEFYAQCEKVGVDSVLVADVPIEESAPFRQAALRHNVAPIFICPPNADDDLLRQIASYGRGYTYLLSRAGVTGAENRAALPLNHLVAKLKEYNAAPPLQGFGISAPDQVKAAIDAGAAGAISGSAIVKIIEQHINEPEKMLAALKVFVQPMKAATRS
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
B7LY16
Q12GB2
TGT_POLSJ
tRNA-guanine transglycosylase
unclassified Polaromonas
MLEFEVLKTDARTGEGANAHPGSHARRGQLTLTHGVVQTPIFMPVGTYGTVKGVMPQSLHEMGAQIILGNTFHLWMRPGLDVMKQFGGLHRFESWDKPILTDSGGFQVWSLGDMRKISEEGVKFASPVNGDKLFLTPEISMQIQTVLNSDIVMQFDECTPYDTKGHITTESEARSSMELSLRWAKRCVAEFDKLENPNALFGIVQGGMYQNLRHESLEALVELDLPGYAVGGVSVGEPKEEMQRIMAHTPHRLPADKPRYLMGVGTPEDLVEGVGAGIDMFDCVMPTRNARNGHLFTRFGDLKIRNARHKADEQPLDTTC...
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks th...
Q12GB2
Q1MAQ8
TSAD_RHIL3
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Rhizobium
MVPFLRILGIETSCDETAAAVVERDAEGHSNVLSDVVLSQLDEHSAYGGVVPEIAARAHVEALDELIEEALKRANVSLNDVDAIAATSGPGLIGGLLVGLMTGKAIARAAGKPLYAINHLEGHALTARLTDGLSFPYLMLLVSGGHTQLILVRGVGQYERWGTTIDDALGEAFDKTAKLLGLPYPGGPAVERMARDGNPDRFDFPRPLVGEARLDFSFSGLKTAVRQAAQDIAPLSDQDVADICASFQKAVSRTLKDRIGRGLQRFKTEFPATGEKPALVVAGGVAANLELRGTLQALCNKNGFRFIAPPLHLCTDNAVM...
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct ca...
Q1MAQ8
P36598
THI1_SCHPO
Transcription factor ntf1
Schizosaccharomyces
MNEEIGFLKNQLFADVKDLERKKKRRVPPEQRRRVFRACKHCRQKKIKCNGGQPCISCKTLNIECVYAQKSQNKTLSREYLEELSERQLCLEYIFSRMCPNFNLETKNLISISKKLSENENLPVSKIAEVTNELDTLVRINDQLSRNHISGTTEEMQSSSSLIAGEVQPGISFRDQLKVGKLEDTLYLGPTTSEAFIERLQNELELESISEDDLYSKRLSPSVSYSEFDEQLLLHARSLIPSKAVVEFLINSFFINVQTNLFVYHPHFFKCRLEIFLAMENQIDAGFLCILLMVLAFGNQYTAEQQEDVSKSNFHASNIG...
Transcription factor that activates the nmt1 promoter. Regulation of thiamine repressible genes. Positively regulates conjugation during meiosis.
P36598
A8AKT3
THIG_CITK8
Thiazole synthase
Citrobacter
MLRIADKTFDSHLFTGTGKFASSQLMVEAIRASGSQLVTLAMKRVDLRQHNDAILAPLIDAGVTLLPNTSGAKTAEEAIFAAQLAREALGTHWLKLEIHPDARWLLPDPVETLKAAEALVKQGFVVLPYCGADPVLCKRLEEVGCAAVMPLGAPIGSNQGLETRAMLEIIIQQATVPVVVDAGIGVPSHATQALEMGADAVLVNTAIAVADDPVMMAQAFRLAVEAGVMARRAVPGTRSSYAQATSPLTGFLEASA
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
A8AKT3
Q97LP3
Y511_CLOAB
Nucleotide-binding protein CA_C0511
Clostridium
MRFVIVTGLSGAGKTQAIRSLEDLGYFCIDNLPPALIPKFAQVCYESESKINKIALVIDIRGGEFFDNLFESLKYLKEAGYKYEILFLDADNEVLIKRFKESRRKHPLAPNGRILNGIQMERKKLKTLYNMANNVIDTSKLATRELREKINSIYQEEGQIESKLIVTVVSFGFKYGIPVDSDLVFDVRFLPNPFYIPELKRFSGIEKPVKDYVMSFDQTKEFVNKIEQLLKFLIPNYLKEGKRQLIVSIGCTGGRHRSVTIANEIYERLKNDGETVNIDHRDIEEDINKGGKKL
Displays ATPase and GTPase activities.
Q97LP3
Q9BXA7
TSSK1_HUMAN
Serine/threonine-protein kinase 22A
Homo
MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQP...
Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the f...
Q9BXA7
Q8Z996
TILS_SALTI
tRNA(Ile)-lysidine synthetase
Salmonella
MTTLTLNTSLLSSRRILAAFSGGLDSTVLLHQLVLWRERHPDVTLRAIHIHHGLSPHADSWVRHCETVCERWQVPLVVERVTLADNGLGIEAHAREARYRAFAQTLLPGEVLATAQHLDDQCETFLLALKRGSGPAGLSAMGERSPFAGTLLLRPLLRETRKTLEQWAVRHGLCWIEDESNQDDAYDRNFLRLRALPLLQQRWPHFPAAVARSATLCAEQERLLDELLASDLTDCITTEGTLRLSPLMSMSDVRRAAILRRWLAMRNAPMPSRDALERIWQEVALARDDASPCLRFGDHEIRRYQSQLWWIKTVAGQHET...
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
Q8Z996
B2U6Y7
TRPA_RALPJ
Tryptophan synthase alpha chain
Ralstonia
MSRIAQTFSQLSAQGRKGLIPFITAGDPYPEMTVDLMHALVKGGSNVIELGVPFSDPMADGPVIQRASERALAKKVGLRTVLEYVRAFRATDLTTPVVLMGYANPIERMGVDAFAKAASEAGVDGVLVVDYPPEECEAFAKTMRAAGIDPIFLLAPTSTEARIAQIARVASGYIYYVSLKGVTGAATIDLDAVAARIPQIRQHARLPVGVGFGIRDAATARAISGVADAVVIGSRIVQLLEEAPREQAVQYLTDFIAEIRQALDA
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
B2U6Y7
B3DR08
TILS_BIFLD
tRNA(Ile)-lysidine synthetase
Bifidobacterium
MAYSARLRKAVGAVRTTLSAVELCDVQAPEFAQHGDHAVASDAPLVLVACSGGRDSMALAAVSHIVCTSMGVRCGVVIVDHGLQEGSEQVAGEAANRCRALGLGPVIVRNATVQARGEGLEAAARQARYNELCAAARESGAIAVLLAHTMDDQAETVLIGLLRSRGVDALAGMPQVFTRSGVTFARPLLTLTRAETTGICEDLGVEYWDDPTNGDAVDGELPNDYPLRSRVRHDLLPAIERFAGFNVTRHFAESARLARMDKEYLDQRSDEVMGEAVTTVDWPASSAAVSTDTPRACAAGDTNDSSHGVGLMISVRRIAR...
Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.
B3DR08
P85800
VARI_AMBVA
Variegin
Amblyomma
SDQGDVAEPKMHKTAPPFDFEAIPEEYLDDES
Thrombin inhibitor. Does not inhibit other serine proteases.
P85800
Q9JT57
TYSY_NEIMA
Thymidylate synthase
Neisseria
MKAYLDLMRHVLDNGTDKSDRTGTGTRSVFGYQMRFDLGKGFPLLTTKKLHLRSIIHELLWFLKGDTNIKYLKDNNVSIWDEWADENGDLGPVYGYQWRNWPAPDGRHIDQIANVLEQIKKNPDSRRLIVSAWNPALVDEMALPPCHALFQFYVADGKLSCQLYQRSADIFLGVPFNIASYALLTMMMAQVCGLEAGEFVHTFGDAHLYRNHFEQAALQLEREPRALPVMKINPEVKDLFAFKFEDFELEGYDPHPHIKAAVSV
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracell...
Q9JT57
Q63EC6
TRPA_BACCZ
Tryptophan synthase alpha chain
Bacillus cereus group
MGVERIQAAFENGKKAFIPYVMGGDGGLEILKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIFQALIEARKEVQIPFVLMTYLNPVLAFGKERFIENCMEAGVDGIIVPDLPYEEQDIIAPLLREANIALIPLVTVTSPIERIKKITSESEGFVYAVTVAGVTGVRQNFKDEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEKREEICEFIQATKQKEEA
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Q63EC6
Q7VRL0
TPIS_BLOFL
Triose-phosphate isomerase
Candidatus Blochmannia
MKNLSIIANWKLNGNKNTITNSLINLTTQLTNIPQYIKIAIAPPILYIDMVKNHLTSYNNKTIELCSQNVDIHLSGAFTGDISASMLKDLSVKYVLIGHSERRIYHKENNSLIAQKFSIIKQTELIPILCIGENKEERDSGSTQSICIQQIDSIIKLVGIKAFENTIIAYEPVWAIGSGSSASPRNVQSIHQFIRNYIAQYDKTIANQISIQYGGSITTDNVLEFITQKDIDGVLVGSASLDIRNLIKIINLSSNLIKKTYQ
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q7VRL0
Q6HLU3
TRPA_BACHK
Tryptophan synthase alpha chain
Bacillus cereus group
MGVERIKAAFENGKKAFIPYVMGGDGGLEILKERIRFLDEAGASIVEIGIPFSDPVADGPTIQRAGKRALDSGVTVKGIFQALIEVREEVQIPFVLMTYLNPVLAFGKERFIENCMEAGVDGIIVPDLPYEEQDIIAPLLREANIALIPLVTVTSPIERIKKITSESEGFVYAVTVAGVTGVRQNFKDEIHSYLEKVKSHTHLPVVAGFGISTKEHVEEMVTICDGVVVGSKVIELLENEKREEICEFIQATKQKEEA
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.
Q6HLU3
Q896K7
VATE1_CLOTE
V-ATPase subunit E 1
Clostridium
MSRLENLTSKIIKDSEEKAKIILDEAKREEEKIMLGQKQEGESIKSKIIEKAYLESKNRKERIISNSHLFVRNRKLEAKQEVIDKVYKEALNKLAKLNKEEYLNFIKDSILALEIYGDEEIILSQDEKYINKETIEEINKELKSKGKKGEIKISDKKRDFRGGFILNKDGIEINNTFEALILSLKDDLEPVIIDTLFS
Produces ATP from ADP in the presence of a proton gradient across the membrane.
Q896K7
C5BSX6
Y3824_TERTT
Nucleotide-binding protein TERTU_3824
Teredinibacter
MRLLIISGRSGSGKTTALHLLEDEGYTCIDNLPVDLLPALIEQLSTSDRPSPRVAIGIDARNINNDLSRLMAMIEVGPLPRESYQVIYLDSSREVLLKRYSETRRKHPLSDGLTDLNEAIERERIILEPISNAADVTIDTSQLNLHELRSAIKYLVVGSDREGMAVLFKSFGFKYGLPVDADFVFDVRCLPNPYWDAGLRKLSGLSPEVIAFLNGEEQVEEMYNDILTFMRKWIPRFENNNRSYLTIAIGCTGGFHRSVYMSERLAKALKADYKNVQTRHRQIPDSSAPKHS
Displays ATPase and GTPase activities.
C5BSX6
Q5WSX6
TRHO_LEGPL
tRNA hydroxylation protein O
Legionella
MKDIIIASFYKFIPLNDFESLREPILTKMHEIGIKGTIILAHEGVNGGFAGNREQMYIFYDYLRSDSRFADLHFKETYDNKNPFDKAKVKLRKEIVTMGVQKVDPSYNAGTYLSPEEWHQFIQDPNVILLDTRNDYEYELGTFKNAINPDIENFREFPDYVQRNLIDKKDKKIAMFCTGGIRCEKTTAYMKELGFQHVYQLHDGILNYLESIPEGESLWEGKCFVFDDRVAVDQKLDRVYPQLPQDYKYEREQK
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
Q5WSX6
A6U170
XERC_STAA2
Tyrosine recombinase XerC
Staphylococcus
MNHIQEAFLNTLKVERNFSEHTLKSYQDDLIQFNQFLEQEHLQLKTFEYRDARNYLSYLYSNHLKRTSVSRKISTLRTFYEYWMTLDENIINPFVQLVHPKKEKYLPQFFYEEEMEALFKTVEEDTSKNLRDRVILELLYATGIRVSELVNIKKQDIDFYANGVTVLGKGSKERFVPFGAYCRQSIENYLEHFKPIQSCNHDFLILNMKGEAITERGVRYVLNDIVKRTAGVSEIHPHKLRHTFATHLLNQGADLRTVQSLLGHVNLSTTGKYTHVSNQQLRKVYLNAHPRAKKENEI
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plas...
A6U170
G3Y423
YANE_ASPNA
Yanuthone D biosynthesis cluster protein E
Aspergillus subgen. Circumdati
MAPCKPRTFTAGEDPLTKFDGAISVATMPRPADRQFLFHGIMRPSRGIYAKLVATGKKPPTHFHPSQWEFFRVLRGNLTVDINGVPVHRTVDDGEMAVPPYTHHVIYGTPGTEMNEVEFLVSATDEEEGATAMDQEFFENWYGYQEDIFQRGEKIDLIQVLAMFDAGGTYLSPPWWVPFRAWVGLILGIVIGRWIGGLLGYAPFYPEWTTNWDAACDRMEQSWFQRRYADRGAQQRAREKFQVQKGQGTVAKGEKSE
Part of the gene cluster that mediates the biosynthesis of yanuthone D, a fungal isoprenoid epoxycyclohexenone that acts as an antibiotic against fungi and bacteria . The first step of the pathway is the synthesis of 6-methylsalicylic acid (6-MSA) by the polyketide synthase yanA . 6-MSA is then converted to m-cresol by...
G3Y423
P17795
VIRB5_AGRFC
Protein virB5
Agrobacterium tumefaciens complex
MKIMQLVAAAMAVSLLSVGPARAQFVVSDPATEAETLATALETAANLEQTITMVAMLTSAYGVTGLLTSLNQKNQYPSTRDLDTEMFSPRMPMSTTARAITTDTDRAVVGGDAEADLLRSQITGSANSAGIAADNLETMDKRLTANAETSTQLSRSRNIMQATVTNGLLLKQIHDAMIQNVQATSLLTMTTAQAGLHEAEEAAAQRKEHQKTAVIFGAVP
VirB proteins are suggested to act at the bacterial surface and there play an important role in directing T-DNA transfer to plant cells.
P17795
A7ZX76
THII_ECOHS
tRNA 4-thiouridine synthase
Escherichia
MKFIIKLFPEITIKSQSVRLRFIKILTGNIRNVLKHYDETLAVVRHWDNIEVRAKDENQRLAIRDALTRIPGIHHILEVEDVPFTDMHDIFEKALVQYRDQLEGKTFCVRVKRRGKHDFSSIDVERYVGGGLNQHIESARVKLTNPEVTVHLEVEDDRLLLIKGRYEGIGGFPIGTQEDVLSLISGGFDSGVSSYMLMRRGCRVHYCFFNLGGAAHEIGVRQVAHYLWNRFGSSHRVRFVAINFEPVVGEILEKIDDGQMGVILKRMMVRAASKVAERYGVQALVTGEALGQVSSQTLTNLRLIDNVSDTLILRPLISYD...
Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynt...
A7ZX76
P38709
UGPA2_YEAST
UDP-glucose pyrophosphorylase
Saccharomyces
MTVFSGVNKIEFEGTFEGIGKDVVMSQMIRALQKHFPSIRDKNYEFSLFLHIFQRYVLENTSITHDLVCDKIRLPIIDEVVELDDIKNYGLLEGKLLSKLAILKLTGKANPIIGKESPLFEVKNGMSSLDVIVRQTQNLNVRYNSDVPLIFMTSLETESQVSNFLEEHYSSSKVRWKTVVQSSFPQIDKDRLLPIDLQINSHENDFWYPCGTGNLTDTLYFSGELDKLIAQGKEILFVSNVDNLGATGDLNILNFIINEKIEYLVEVVERTANVSNTGVLATYKGKLRSVYYNCLSNESASTCRIVNTNNIWIDLKKLKV...
Plays a central role as a glucosyl donor in cellular metabolic pathways.
P38709
A4QJH4
TI214_AETCO
Translocon at the inner envelope membrane of chloroplasts 214
Aethionema
MMVFQSFILGNLVSLCMKIINSVVVVGLYYGFLTTFSIGPSYLFLLRARVMDEGEEGTEKKVSATTGFIAGQLMMFISIYYAPLHLALGRPHTITVLALPYLLFHFFWNNHKHFFDYGSTTRNEMRNLRIQCVFLNNLIFQLFNHFILPSSMLARLVNIYMFRCNNKMLFVTSSFVGWLIGHILFMKWVGLVLVWIQQNHSIRSNVLIRSNKYKFLVSELRNSMARIFSILLFITCVYYLGRIPSPIFTKKLKGTSETEERGGTKQDQEVSTEEAPFPSLFSEEREDLDQIDEIDEIRVNAKEQINKDDEFHIRTYYNYK...
Involved in protein precursor import into chloroplasts. May be part of an intermediate translocation complex acting as a protein-conducting channel at the inner envelope.
A4QJH4
D6PXE8
VM3B_NAJAT
Snake venom metalloproteinase
Naja
MIQALLVIICLAVFPHQGSSIILESGNVNDYEVVYPQKVPALLKGGVQNPQPETKYEDTMRYEFQVNGEPVVLHLERNKGLFSEDYTETHYAPDGREITTSPPVQDHCYYHGYIQNEADSSAVISACDGLKGHFEHQGETYFIEPLKISNSEAHAIYKDENVENEDETPEICGVTETTWESDESIEKTSQLTNTPEQDRYLQDKKYIEFYVIVDNRMYRYYNNDKPAIKIRVYEMINAVNTKFRPLKIHIALIGLEIWSNKDKFEVKPAASVTLKSFGEWRETVLLPRKRNDNAQLLTGIDFNGNTVGRAYIGSLCKTNE...
Snake venom zinc protease that inhibits the classical and alternative pathways of complement by cleaving factor B, C6, C7, and C8. Also slowly and selectively degrades alpha-chain of fibrinogen (FGA), and shows edema-inducing activity.
D6PXE8
Q9Z7W2
YIDD_CHLPN
Putative membrane protein insertion efficiency factor
Chlamydia
MSFKRFLQQIPVRICLLIIYLYQWLISPLLGSCCRFFPSCSHYAEQALKSHGFLMGCWLSIKRIGKCGPWHPGGIDMVPKTALQEVLEPYQEIDGGDSSHFSE
Could be involved in insertion of integral membrane proteins into the membrane.
Q9Z7W2
B2HNX5
TAM_MYCMM
Trans-aconitate 2-methyltransferase
Mycobacterium
MWDPDVYLAFADHRGRPFYDLVSRIGAKRARRVVDLGCGPGNLTRYLARRWPEAIIEAWDSSPQMVAAARERGIDATTGDLRTWKPKPDTDVVISSAALHWVPEHADLMVQWATELPHGSWIAVQVPGNFETPSHAVVRALARREPYAKLMRDIPFRVGAVVGSPASYAGLLMDAGCKVDAWETTYLHQLTGKNPVLEWITGTALVPVRERLDDVSWEQFRQELIPLLDDAYPPRSDGTTMFPFRRLFIVAEVGGARRSADVS
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
B2HNX5
Q8Z7A8
TPX_SALTI
Thioredoxin-dependent peroxiredoxin
Salmonella
MSQTVHFQDNPVTVANVIPQAGSKAQAFTLVAKDLSDVSLSQYAGKRKVLNIFPSIDTGVCAASVRKFNQLATEVENTVVLCVSADLPFAQSRFCGAEGLSNVITLSTLRNNEFLKNYGVEIVDGPLKGLAARAVIVLDENDNVIFSQLVDEITHEPDYDAALNVLKA
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.
Q8Z7A8
Q8U0I8
UPPS_PYRFU
Undecaprenyl pyrophosphate synthase
Pyrococcus
MIYRIISHIPSIFFKPAYDLYERYLLEKVKAGVIPKHVAIIMDGNRRWARKREKPPWYGHFFGSKKLEEIVEWCHELGIRILTVYAFSTENFKRSKEEVDRLMKLFEEKFRELVTDRRVHEYGIRVNVMGRKELLPKNVREAAEEAERVTRKYNNYFLNIALAYGGRSEIVDAIKDIVNDVLEGRLKLEDINEEIVRKYLYVPNMPDPDIVIRTGGEVRISNFLLYQIAYSELFFVDVYFPEFRKIDFLRIIREFQKRERRFGR
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
Q8U0I8
Q8E471
UVRB_STRA3
Excinuclease ABC subunit B
Streptococcus
MIDRKDTNRFKLVSKYSPSGDQPQAIETLVDNIEGGEKAQILKGATGTGKTYTMSQVIAQVNKPTLVIAHNKTLAGQLYGEFKEFFPDNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYADSVVSLRPGQEISRDQLLNNLVDIQFERNDIDFQRGKFRVRGDVVEVFPASRDEHAFRIEFFGDEIDRIREIESLTGRVLGEVEHLAIFPATHFMTNDEHMEEAISKIQAEMENQVELFEKEGKLIEAQRIRQRTEYDIEMLREMGYTNGVENYSRHMDG...
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP bindi...
Q8E471
A8AKQ0
XGPT_CITK8
Xanthine phosphoribosyltransferase
Citrobacter
MSEKYVVTWDMLQIHARKLASRLMPSEQWKGIIAVSRGGLVPGALLARELGIRHVDTVCISSYDHDNQRELKVLKRAEGDGEGFIVIDDLVDTGGTAVAIREMYPKAHFVTIFAKPAGRPLVDDYVIDIPQDTWIEQPWDMGVVFVPPISGR
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with...
A8AKQ0
B5RMW0
TSAD_BORDL
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Borrelia
MKVLGIESSCDDCCAAIVENGNTILSNIKLSQKEHKKYYGIVPEIASRLHTEFIMYVCQQAIISAQINISEIDLIAVTSQPGLIGSLIVGVNFAKGLSIALKKPLICIDHILGHLYAPLLNHTIEYPFLSLVLSGGHTILAKQNNFDDIEILGRTLDDACGEAFDKIAKHYKMGFPGGPNIEKLAIDGNQYAFNFPITIFDKKENRYDFSYSGLKTACIHQLEKFKNNNAQITNNNIAASFQRAAFENLIIPIKRAIKDTNIKKLIISGGVASNLYLREKIKNLEIETYYPPIDLCTDNAAMIAGIGYLMYLKYGASSIE...
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct ca...
B5RMW0
P39603
YWCE_BACSU
Spore morphogenesis and germination protein YwcE
Bacillus
MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFYATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS
Required for proper spore morphogenesis. Important for spore germination.
P39603
A1K7B7
TRUB_AZOSB
tRNA-uridine isomerase
Azoarcus
MQRKIPRRIVDGVLLLDKPSGMTSNGALQTARRLLNAAKAGHTGTLDPMASGLLPLTFGEATKFSQILLDADKTYEAGVKLGTTTDTGDADGNVVAEHPVSVTREALEEVLSRFRGEIDQLPPMYSALKRDGKPLYEYARAGIEIEREVRRVTIHDLELIAFSGEHFSMRVRCSKGTYIRTLAMDIGAALGCGAYLDALRRTAIGDFDAARAVTLEALEASPAAMRDGLLEPVDALVAHFPKVELQPAEAAAILQGRELRKPEDGQGSVRLFCGGRFLGVGEWQSGSLRPKRLIATQTGQ
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
A1K7B7
Q6NYY9
VMP1_DANRE
Vacuole membrane protein 1
Danio
MAANGAECEQPQKRLGPKDKQNGSSTDSSLRERKQLDREERLSLVLWKRPFITLQYFFLETAITLKEWTWKLWQRRGVVFLTVVLFSLFSLAYSIEGAHQEYVQHLEKKFLWCAYWVGLGILSSVGLGTGLHTFLLYLGPHIASVTLAAYECGSVNFPEPPYPAQIVCPEDEALQESISLWTIMSKVRLEACMWGAGTAIGELPPYFMARAARMSGADPDDEDYEEFEEMLEHSQSAQDFASRAKLAVQNMVQKVGFFGILACASIPNPLFDLAGITCGHFLIPFWTFFGATLIGKAIIKMHIQKLFVIITFSKHIVEQM...
Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenes...
Q6NYY9
Q9C040
TRIM2_HUMAN
RING-type E3 ubiquitin transferase TRIM2
Homo
MASEGTNIPSPVVRQIDKQFLICSICLERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITNLMDVLQRTPGSNAEESSILETVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTEGEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIVDDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTAQALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGTILT...
UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
Q9C040
Q5D7I6
TRIM5_ALOSA
TRIM5alpha
Alouatta
MASKILVNIKEEVTCPICLELLTEPLSLDCGHSFCQACITANHKESRERSCPLCRVSYHSENLRPNRHLANIAERLREVMLSPEEGQKVDRCARHGEKLLLFCQQHGNVICWLCERSEEHRGHRTSLVEEVAQKYREKLQAALEMMRQKEQDAEMLEADVREEQASWKIQIENDKTSTLAEFKQLRDILDCEESNELQKLEKEEENLLKRLVQSENDMVLQTQSIRVLIADLERRLQGSVMELLQGVEGVIKRIKNVTLQKPETFLNEKRRVFQAPDLKGMLQVFKELKEVQCYWAHVTLIPNHPSCTVISEDKREVRYQ...
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates i...
Q5D7I6
Q6F7W2
XPT_ACIAD
Xanthine phosphoribosyltransferase
Acinetobacter
MYALEQKILNEGIVLSDQVLKVDAFLNHQIDPVLMQQIGKEFAARFKDTGITKIVTIEASGIAPAVMAGLELGVPVIFARKYQSLTLKDDLYRSKVFSFTKQVESTIAISNKHINAEDKVLVIDDFLANGQAALGLIDLIHQANADIVGVGIVIEKSFQPGRDLLLEKGYRVESLARVASLTNGQVTFVIE
Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
Q6F7W2
Q04TG5
YBEY_LEPBJ
Endoribonuclease YbeY
Leptospira
MIFNCGILFRKELKDFPCELGLLLVGDSDMRKINRLRRGKDKTTDVLSFPLEFDSAPLQNVLQKRTGFDSNSLPPIALGEIVISVDTLEKQAVEIGHSVKDEFYRLLVHGFLHLLGYDHERGEEEERIMKLKEDECLEILQEL
Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
Q04TG5
Q9PGJ7
TPIS_XYLFA
Triose-phosphate isomerase
Xylella
MRPKIVAGNWKLHGSHAFAQALVAQVAAGLPLLGVSVIILPPLLYLSDLAQRFKGEGLAFGAQNVSHHDKGAYTGEVSAAMVADVGAHYTLVGHSERREYHHEDSELVARKFAAALSAGLRPILCVGESLPQREAGQAEVAIAMQLAPVLALVGPQGVARGLIAYEPVWAIGTGRHADPSQVQAMHAFIRGEIARQDARIGDSLLILYGGGIKPCNAAELFSQQDVDGGLIGGASLVADDFLAIARATV
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
Q9PGJ7
C1CHZ8
TRHO_STRZP
tRNA hydroxylation protein O
Streptococcus
MAKDIRVLLYYLYTPIENAEQFAADHLAFCKSIGLKGRILVADEGINGTVSGDYETTQKYMDYVHSLPGMEELWFKIDEESEQAFKKMFVRYKKEIVHLGLEDNDFDNDINPLETTGAYLSPKEFKEALLDKDTVVLDTRNDYEYDLGHFRGAIRPDIRNFRELPQWVRDNKEKFMDKRVVVYCTGGVRCEKFSGWMVREGYKDVGQLHGGIATYGKDPEVQGELWDGKMYVFDERIAVDVNHVNPTIVGKDWFDGTPCERYVNCGNPFCNRRILTSEENEDKYLRGCSHECRVHPRNRYVSKNELTQAEVIERLAAIGE...
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
C1CHZ8
A9VKK9
TRMB_BACMK
tRNA(m7G46)-methyltransferase
Bacillus cereus group
MRLRHKPYAMDRINEYSHIVIGNPEESAGNWKEIFGNEQPIHIEVGTGRGRFMYDMAKANPHINYIGIEKFTSVVVDALDKLIEEEVPNLKLINKDAEDLTVFFAKGEIDRVYLNFSDPWPKNRHTKRRLTYKTFLRNYEEVLVDGGEIHFKTDNQGLFEYSIMSMAEYGMLLTYLSLDLHNSDYEGNIMTEYEEKFSSKGHRIYRVEAKYRTEPMQ
Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
A9VKK9
Q80WQ2
VAC14_MOUSE
Protein VAC14 homolog
Mus
MNPEKDFAPLTPNIVRALNDKLYEKRKVAALEIEKLVRDFVAQNNTMQIKHVIQTLSQEFALSQHPHSRKGGLIGLAACSIALGKDSGLYLKELIEPVLTCFNDADSRLRYYACEALYNIVKVARGAVLPHFNVLFDGLSKLAADPDPNVKSGSELLDRLLKDIVTESSKFDLVSFIPLLRERIYSNNQYARQFIISWILVLVSVPDINLLDYLPEILDGLFQILGDNGKEIRKMCEVVLGEFLKEIKKNPSSVKFAEMANILVIHCQTTDDLIQLTAMCWMREFIQLAGRVMLPYSSGILTAVLPCLAYDDRKKSIKEV...
Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coor...
Q80WQ2
Q6KHL5
TRMD_MYCMO
tRNA [GM37] methyltransferase
Mesomycoplasma
MINIEIIDFRNFAYGKQKKVDDEIYGGGSGMLLKIEPIDLALENTKGKRILLSPQGKPFTQDDALKLSKEENLTFICGRYEGFDERIRNLIDEEYSIGDYVLTGGELASMVIADSTIRLIPGVIKEESYKNDSFQNNLLDYPQYTRPATYKNMNVPEVLLNGNHKEIKQWREQKAYEKTLKNRPDLIERKNNAK
Specifically methylates guanosine-37 in various tRNAs.
Q6KHL5
O32126
YUTE_BACSU
Putative toxin HepT
Bacillus
MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHLLIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQYLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK
Probable toxic component of a putative type VII toxin-antitoxin (TA) system, probably an RNase. Probably neutralized by cognate antitoxin YutD.
O32126
A4WE62
ZAPA_ENT38
Z ring-associated protein ZapA
Enterobacter
MSAQPVDLQIFGRSLRVNCPPEQRDALSQAADDLNQRLQDLKERTRVTNTEQLVFIAALNISYELTQEKAKTRDYAASMEQRIKMLQQTIEQALLDQGRTPERPGQKFE
Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division.
A4WE62
Q7M711
TR113_MOUSE
Taste receptor type 2 member 113
Mus
MVAVLQSTLPIIFSMEFIMGTLGNGFIFLIVCIDWVQRRKISLVDQIRTALAISRIALIWLIFLDWWVSVHYPALHETGKMLSTYLISWTVINHCNFWLTANLSILYFLKIANFSNIIFLYLKFRSKNVVLVTLLVSLFFLFLNTVIIKIFSDVCFDSVQRNVSQIFIMYNHEQICKFLSFTNPMFTFIPFVMSTVMFSLLIFSLWRHLKNMQHTAKGCRDISTTVHIRALQTIIVSVVLYTIFFLSFFVKVWSFVSPERYLIFLFVWALGNAVFSAHPFVMILVNRRLRLASLSLIFWLWYRFKNIEV
Putative taste receptor which may play a role in the perception of bitterness.
Q7M711
P42244
YCBL_BACSU
Uncharacterized transcriptional regulatory protein YcbL
Bacillus
MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDLVLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMIELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLLCLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWGIGYKLGEF
Member of the two-component regulatory system YcbM/YcbL.
P42244
P07871
THIKB_RAT
Peroxisomal 3-oxoacyl-CoA thiolase B
Rattus
MHRLQVVLGHLAGRSESSSALQAAPCSAGFPQASASDVVVVHGRRTPIGRAGRGGFKDTTPDELLSAVLTAVLQDVKLKPECLGDISVGNVLQPGAGAAMARIAQFLSGIPETVPLSAVNRQCSSGLQAVANIAGGIRNGSYDIGMACGVESMTLSERGNPGNISSRLLENEKARDCLIPMGITSENVAERFGISRQKQDAFALASQQKAASAQSKGCFRAEIVPVTTTVLDDKGDRKTITVSQDEGVRPSTTMEGLAKLKPAFKDGGSTTAGNSSQVSDGAAAVLLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIG...
Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) . Plays an important role in fatty acid peroxisomal beta-oxidation . Catalyzes the cleavage of short, medium, long, and very long straight chain 3-oxoacyl-CoAs . Medium chain straight 3-oxoacyl-CoAs are preferred substrates...
P07871
Q3SI71
TATA_THIDA
Sec-independent protein translocase protein TatA
Thiobacillus
MGSFSIWHWLIVLVVVLLIFGTKKLRNIGSDLGGAVKGFKEGMKDDAPKISESDKGGHTIDAEVKDKQNS
Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
Q3SI71
Q9YE67
TOP6A_AERPE
Type II DNA topoisomerase VI subunit A
Aeropyrum
MSGEMFGDEVDIKARLRAAEVMYKKFHRLISDVIKGRPPKLEIPKRTLSNTIFDPERGILVIGEEKLEREFLNVGESRRFMQTLLMASIIYQSLIENEYPTIRDLYYKGKHTIVYRDYSGRKREENTWDEQKESDSVIQDIEVYTGLFREDMLILSKEKGKVVGNMRIRSGGDVIDLSKLGHGAYAIEPTPDLIEFLDVDAEFVLVVEKDAVFQQLHRAGFWKKYKALLVTGSGQPDRATRRFVRRLHEELKLPVYIITDSDPYGWYIYSVYKVGSITLSYESERLATPKAKFLGVQMTDIFGYRGKKPYLSEAERKKFM...
Relaxes both positive and negative superturns and exhibits a strong decatenase activity.
Q9YE67
A4Y2Q3
UBIB_SHEPC
Ubiquinone biosynthesis protein UbiB
Shewanella
MTLTSIRRGYHVIKTLLQYGLDEVLPPKMTPWYFTLARSSLFWIRNKHKSKPGGERLKLAMQELGPVYIKLGQMLSTRRDLLSDEWAIELAMLQDKVPPFDGVLARKAIEAELKASIESLFDDFDETPLASASISQVHTATLKSNGKAVVLKVLRPNVEAKILADLQLMSQTANLLEYFLGEGNRLRPAEVIEDYRVTILGELNLKLEALNAIKLRNNFLNSDALYVPYVYEEFCYPRLMVMERIYGIPVSDIAALKAQGTNFKLLAERGVELFFTQVFRDNFFHADMHPGNIFISRDHPENPYYIGLDCGIMGTLSEVD...
Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis.
A4Y2Q3
A5FWG2
UPPP_ACICJ
Undecaprenyl pyrophosphate phosphatase
Acidiphilium
MTPLIAVLFAILQGATELFPVSSLGHVVIVPALLHWPIDQASPSFLPFVVMLHVGTATALLLYFWREWWAMLAGLLGRGEPGEVDAQRGLLLRLVVATLPAVLIGFALKKPIQHLFASPEIAAAFLIANGAVLIIGERLRRRRAGNGFGIGQLTLRDSLVIGLFQCLAFLPGLSRSGSAIVGGLTRGLDHEAAARFAFLMATPVIAGAAVIEVPHLLHHAAAARGMFGTALLAAVVAGVVAYLSTAFLMRYFRNHDRWALGPFAAYCALFGALSLILIPFGA
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
A5FWG2
S0DHV6
VEA_GIBF5
Velvet complex subunit 1
Fusarium fujikuroi species complex
MATPSSIPAEPKRDVVNRIHRVTRGNRSLWYQMTVLQQPERARACGSGSKANSDRRPVDPPPVVELRIIEGPSVEEGKDITFDYNANFFLYASLEHARPLARGRVNTPAAGNPPILTGVPASGMAYLDRPTEAGYFIFPDLSVRHEGLYILTFSLFETTKEERDFDLEPADGDLPPGVDYRMEIKTDPFSVYSAKKFPGLMESTQLSKTVADQGCQVRIRRDVRMRKRESKPGAGNSNSGGNGFERREEDFGRRRTITPASEDPHSIRNRSHSNSSEQRTPYTDASRRPSMVDSYPPPPPPPSYEPAPSASRHLDFGDSS...
Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination . The velvet complex hat acts as a global regulator for secondary metabolite gene expression ....
S0DHV6
Q66EN1
THIQ_YERPS
Thiamine import ATP-binding protein ThiQ
Yersinia
MLKLEKITYLYDHLPMCFDLHIQPGERVAILGPSGAGKSTLLSLIAGFLAPTSGHMLLNNQDHTASPPAQRPVSMLFQENNLFAHLTVEQNIGLGLHPGLKLSGEQRLLLQHIAQQVGLESCLDRLPAQLSGGQRQRAALARCLVRSQPILLLDEPFSALDPALRNEMLQLVDQVCINRQLTLLMVSHNLDDAARIAQRTLLIVEGRIDYDGPTQALVDGSAAKASVLGIKSAVIS
Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system.
Q66EN1
A5UF28
TRUB_HAEIG
tRNA-uridine isomerase
Haemophilus
MSRPRKRWRDVDGVFLLDKPQGMSSNDIMQKVKRLFQANKAGHTGALDPLATGMLPICLGEATKFSQFLLDADKRYLVTAKLGERTDTSDAEGQVVETREVHVETPQILTALEQFRGDILQVPTMFSALKHNGKPLYEYARQGITVEREARPITIFELNFIEYHAPFLTLEVHCSKGTYIRTLVDDLGEVLGCGAHVTMLRRTAVADYPVAEMMLINELELLAESFPLSELDRLLLPTDTAVSKLPALHLDVEQSKAIGFGQRVKFANEQQLSGQVRLFSAENLFLGVALIDGNIIRPQRLITQSA
Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.
A5UF28
C0JRZ9
TSRM_STRLU
Tryptophan 2-C-methyltransferase
Streptomyces
MLRKGTVALINPNQIHPPIAPYALDVLTTALEASGFEAHVLDLTFHLDDWRQTLRDYFRAERPLLVGVTCRNTDTVYALEQRPFVDGYKAVIDEVRRLTAAPVVAGGVGFSTMPFALVDYFGIEYGVKGPGEKIICDLARALAEGRSADRIHIPGLLVNRGPGNVTRVAPPALDPRAAPAPSSSPSPSPAPSSSSAPVPVPLSFAAVGHHESRAWQAETELPYTRRSGEPYKVDNLRYYREGGLGSILTKNGCVYKCSFCVEPDAKGTQFARRGITAVVDEMEALTAQGIHDLHTTDSEFNLSIAHSKNLLREIVRRRDH...
Involved in the biosynthetic pathway of the antibiotic thiostrepton A. First, TsrM catalyzes the transfer of a methyl group from S-adenosyl methionine (SAM) to cobalamin, leading to the formation of methylcobalamin (CH3-cobalamin) and S-adenosyl-L-homocysteine (SAH). Then the methyl group is transferred to the C2 posit...
C0JRZ9
Q1ACJ2
YCF4_CHAVU
Photosystem I assembly protein Ycf4
Chara
MKIKPCKSQVFRLEPIIGSRKYINYFWSFSIFFGAFGFLIVGICSYLKKELFFFSAENIIFIPQGAVMCFYGIAGIFLSFYLWFTMILGVGSGFNEFNKNEGIVNIFRWGFPGQNRRIKICCLIKDIKSIRIYIRDGISPRSALYLKIRGMPDIPLDVIEDRFNLNEIEKRATELASFLRVPIEGLE
Seems to be required for the assembly of the photosystem I complex.
Q1ACJ2
B1B1U3
ZSS1_ZINZE
Alpha-humulene synthase
Zingiber
MERQSMALVGDKEEIIRKSFEYHPTVWGDYFIRNYSCLPLEKECMIKRVEELKDRVRNLFEETHDVLQIMILVDSIQLLGLDYHFEKEITAALRLIYEADVENYGLYEVSLRFRLLRQHGYNLSPDVFNKFKDDKGRFLPTLNGDAKGLLNLYNAAYLGTHEETILDEAISFTKCQLESLLGELEQPLAIEVSLFLETPLYRRTRRLLVRKYIPIYQEKVMRNDTILELAKLDFNLLQSLHQEEVKKITIWWNDLALTKSLKFARDRVVECYYWIVAVYFEPQYSRARVITSKAISLMSIMDDIYDNYSTLEESRLLTEA...
Catalyzes the formation of alpha-humulene in the first step of zerumbone biosynthesis, a highly promising multi-anticancer agent. Also mediates formation of beta-caryophyllene at a much lower level.
B1B1U3
P0AFQ7
YCFH_ECOLI
Uncharacterized metal-dependent hydrolase YcfH
Escherichia
MFLVDSHCHLDGLDYESLHKDVDDVLAKAAARDVKFCLAVATTLPGYLHMRDLVGERDNVVFSCGVHPLNQNDPYDVEDLRRLAAEEGVVALGETGLDYYYTPETKVRQQESFIHHIQIGRELNKPVIVHTRDARADTLAILREEKVTDCGGVLHCFTEDRETAGKLLDLGFYISFSGIVTFRNAEQLRDAARYVPLDRLLVETDSPYLAPVPHRGKENQPAMVRDVAEYMAVLKGVAVEELAQVTTDNFARLFHIDASRLQSIR
Has D-tyrosyl-tRNA deacylase activity in vitro.
P0AFQ7
Q9V1F9
TYW1_PYRAB
tRNA wyosine derivatives biosynthesis protein Taw1
Pyrococcus
MREMITIKPGKITVQANPNMPEEVANLFRKQHYEIVGRHSGVKLCHWLKKSLTEGRFCYKQKFYGIHSHRCLQMTPVLAWCTHNCIFCWRPMETFLGTELPQPWDDPEFIVEESIKAQRKLLIGYKGNPKVDKKKFEEAWEPKHAAISLSGEPMLYPYMGDLVEEFHKRGFTTFIVTNGTVPERLEEMIKEDKLPTQLYVSITAPDIETYNSVNIPMIPDGWERIMRFLELMRDLPTRTVVRLTLVKGENMHSPEKYAKLILKARPMFVEAKAYMFVGYSRNRLTINNMPSHQDIREFAEALVKHLPGYHIEDEYEPSRV...
Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
Q9V1F9
Q1AU89
TRPD_RUBXD
Anthranilate phosphoribosyltransferase
Rubrobacter
MLREALRKAAAGEPLSEGEAERALETIMEGGASPEATAALLTALRVRGESVQEIVGFARAMRRFAARVRAPEGVVDTCGTGGDAKGTINVSTAAAFVARGAGVVIAKHGNRAATSRAGSADVLEALGAAIELSPEQVSRCIEEAGIGFMFARTHHPAMRHVAPVRAELPFRTVFNLLGPLTNPAGARRQLVGVFSAGYVRPMAEALEGLGAERALVVHGRDGMDEITVTGPTLVAEVGGGGVEEYEISPEDFGLSRHAPDGLLGGDAHLNARILRDVLSGEERGASRDVIVLNAGAAIYVAGKAPSIEEGVRLAEGSLES...
Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).
Q1AU89
Q9GZ70
TPM_PERVI
Tropomyosin
Perna
MDAIKKKMVAMKMEKKNALDRAEQLEQKLRETEEAKAKIEDDYNSLVKKNIQTENDYDNCNTQLQDVQAKYERAEKQIQEHEQEIQSLTRKISLLEEGIMKAEERFTTASGKLEEASKAADESERNRKVLENLNSGNDERIDQLEKQLTEAKWIAEEADKKYEEAARKLAITEVDLERAEARLEAAEAKVIDLEEQLTVVGANIKTLQVQNDQASQREDSYEETIRDLTNRLKDAENRATEAERTVSKLQKEVDRLEDELLTEKEKYKAISDELDATFAELAGY
Tropomyosin, in association with the troponin complex, plays a central role in the calcium dependent regulation of muscle contraction.
Q9GZ70
P80318
TCPG_MOUSE
mTRiC-P5
Mus
MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRMALDDMISTLKKISTPVDVNNREMMLSIINSSITTKVISRWSSLACNIALDAVKTVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIHQLCEDIIQLKPDVVITEKGISDLAQHYLMRANVTAIRRVRKTDN...
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a comple...
P80318