accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
W6Q9S9
FGOX3_PENRF
Old yellow enzyme homolog fgaOx3
Penicillium
MTKLFTPLHVGRMELANRIAMAPMTRYRASDNHVPLPIMKDYYAQRASVPGTLLITEATTISARAGGYANAPGIYNDAQIAAWKEVTDAVHAKGSYIYVQLWAVGRPANPQLLQAEGGYDLVSSSATAVSADAPTPRALSETEIYAWIADYAQAARNAVAAGFDGVEIHAANGYLIDQFTQDICNTRTDAWGGSVQGRARFALEVSRAVVEAVGADRTGIRFSPWSTFQGMRMKDPKPQFEYLAVQTAKLGLAYVHLVESRIAGGADVDATDRLDFFLRAYGKASPVIFAGGYDAESAVRAVDVEYADYDAIVGIGRPFISNPDLPFRVQNGIPFVPYDRATFYVPKDPKGYTDYAFSAEFQKAIEAAA
Chanoclavine-I aldehyde reductase; part of the gene cluster that mediates the biosynthesis of isofumigaclavines, fungal ergot alkaloids . The tryptophan dimethylallyltransferase ifgA catalyzes the first step of ergot alkaloid biosynthesis by condensing dimethylallyl diphosphate (DMAP) and tryptophan to form 4-dimethylallyl-L-tryptophan . The second step is catalyzed by the methyltransferase ifgB that methylates 4-dimethylallyl-L-tryptophan in the presence of S-adenosyl-L-methionine, resulting in the formation of N-methyl-dimethylallyl-L-tryptophan . The catalase ifgD and the FAD-dependent oxidoreductase ifgC then transform N-methyl-dimethylallyl-L-tryptophan to chanoclavine-I which is further oxidized by ifgE in the presence of NAD(+), resulting in the formation of chanoclavine-I aldehyde . The chanoclavine-I aldehyde reductases ifgG and/or fgaOx3 reduce chanoclavine-I aldehyde to dihydrochanoclavine-I aldehyde that spontaneously dehydrates to form 6,8-dimethyl-6,7-didehydroergoline . The festuclavine dehydrogenases ifgF1 and/or ifgF2 then catalyze the reduction of 6,8-dimethyl-6,7-didehydroergoline to form festuclavine . Hydrolysis of festuclavine by a yet undetermined cytochrome P450 monooxygenase (called ifgH) then leads to the formation of isofumigaclavine B which is in turn acetylated by ifgI to isofumigaclavine A . Penicillium roqueforti has interestingly at least two sets of genes for the consumption of chanoclavine-I aldehyde on three different loci, the OYEs ifgG/fgaOx3 and the festuclavine synthase homologs ifgF1/ifgF2 . The reason for the duplication of these genes is unclear, probably to ensure the conversion of chanoclavine-I aldehyde by differential gene expression under various environmental conditions .
W6Q9S9
G5E8F4
FPGT_MOUSE
GDP-L-fucose pyrophosphorylase
Mus
MASLREATLRKLRRFSELRGKPVAAGEFWDVVAITAADEKQELAYKQQLSEKLKKRELPLGVQYHVFPDPAGTKIGNGGSTLCSLECLESLCGDKWNSLKVLLIHSGGYSQRLPNASALGKIFTALPLGEPIYQMLELKLAMYVDFPSNMRPGVLVTCADDIELYSVGDSEYIAFDQPGFTALAHPSSLAVGTTHGVFVLHSDSSLQHGDLEYRQCYQFLHKPTIENMHRFNAVHRQRSFGQQNLSGGDTDCLPLHTEYVYTDSLFYMDHKSAKKLLDFYKSEGPLNCEIDAYGDFLQALGPGATAEYTRNTSHVTKEESQLLDMRQKIFHLLKGTPLNVVVLNNSRFYHIGTLQEYLLHFTSDSALKTELGLQSIAFSVSPSVPERSSGTACVIHSIVDSGCCVAPGSVVEYSRLGPEVSIGENCIISSSVIAKTVVPAYSFLCSLSVKINGHLKYSTMVFGMQDNLKNSVKTLEDIKALQFFGVCFLSCLDIWNLKATEKLFSGNKMNLSLWTACIFPVCSSLSESATASLGMLSAVRNHSPFNLSDFNLLSIQEMLVYKDVQDMLAYREHIFLEISSNKNQSDLEKS
Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate . Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids (Probable).
G5E8F4
O80933
SCL9_ARATH
GRAS family protein 13
Arabidopsis
MITEPSLTGISGMVNRNRLSGLPDQPSSHSFTPVTLYDGFNYNLSSDHINTVVAAPENSVFIREEEEEEDPADDFDFSDAVLGYISQMLNEEDMDDKVCMLQESLDLEAAERSLYEAIGKKYPPSPERNLAFAERNSENLDRVVPGNYTGGDCIGFGNGGIKPLSSGFTLDFRNPQSCSSILSVPQSNGLITIYGDGIDESSKNNRENHQSVWLFRREIEEANRFNPEENELIVNFREENCVSKARKNSSRDEICVEEERSSKLPAVFGEDILRSDVVDKILVHVPGGESMKEFNALRDVLKKGVEKKKASDAQGGKRRARGRGRGRGRGGGGGQNGKKEVVDLRSLLIHCAQAVAADDRRCAGQLLKQIRLHSTPFGDGNQRLAHCFANGLEARLAGTGSQIYKGIVSKPRSAAAVLKAHQLFLACCPFRKLSYFITNKTIRDLVGNSQRVHVIDFGILYGFQWPTLIHRFSMYGSPKVRITGIEFPQPGFRPAQRVEETGQRLAAYAKLFGVPFEYKAIAKKWDAIQLEDLDIDRDEITVVNCLYRAENLHDESVKVESCRDTVLNLIGKINPDLFVFGIVNGAYNAPFFVTRFREALFHFSSIFDMLETIVPREDEERMFLEMEVFGREALNVIACEGWERVERPETYKQWHVRAMRSGLVQVPFDPSIMKTSLHKVHTFYHKDFVIDQDNRWLLQGWKGRTVMALSVWKPESKA
Probable transcription factor involved in plant development.
O80933
Q0HYK9
HEM1_SHESR
Glutamyl-tRNA reductase
Shewanella
MSLVAIGINHKTATVDLREKVAFSPDKIHDAMKSLASRTRSGEAVIVSTCNRTELYCNNGDEADIIEWLEEYHGLDHQDVAPCLYNYHGQAAVKHLMRVASGLDSLILGEPQILGQVKQAFVKAKEAGTVALTIDRLFQNTFSVAKKVRTETEIGAAAVSVAFAAVSMAKHIFSSLSTTKVLLIGAGETIELVAKHLKDNGVASMVVANRTLERAQSMCEEFNATAITLAQIPDFLPKADIVISSTASPLPILGKGMVEKALKQRRHQPMLLVDIAVPRDIEPEVADLDDAFLYTVDDLHSIIEQNKASRKEAAEQAELITEEQSYLFMDWVRSLESVDSIREYRSQSMAIKDELVERALNKLAQGGDTEQVLIELANRLTNRLIHAPTQALTVASRQGDLNTLGQLRTALGLDKN
Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
Q0HYK9
Q8X170
ABCA_ASPFM
ABC multidrug transporter A
Aspergillus subgen. Fumigati
MNESHEAGKNSSTNVEEREEEVLRLARQFTEQSSYSTAGQTPFAAEAGSALDPNGERFNARAWCKAMLQMHIGDKEAHPLRTLGVAFSNLNVHGFGSDTDYQKSVGNVWLKTLSLARIAFGQKQRKVDILQNLEGLVEAGEMLVVLGPPGSGCSTFLKTIAGETYGFHVDKNSNINFQGIAKQMAHEFRGEAIYTAEVDVHFPKLTVGDTLYFAARARTPRHIPGGVNATQYAGHMRDVIMAMFGISHTKNTIVGNDFIRGVSGGERKRVSIAEACLSNAPLQCWDNSTRGLDSANAIEFCKTLRMQADINGTTACVSLYQAPQAAYDYFDKVLVLYEGREIYFGPTSMAKHYFLQMGFVCPDRQTDADFLTSMTSHLERVVQPGYEDRVPRTPDEFAARWKASPQRAQLMQHIKSYNAKFALDGEYLDKFKQSRRAQQAKAQRVSSPYTLSYVQQVKLCLWRGYQRLKADPSVTISSLFGNTIISLVIASIFYNLKADTSTFFQRGALLFFAVLMNALGCGLEMLTLYAQRGIIEKHSRYALYHPSAEAFSSMIMDLPYKILNAITSNIVLYFMTNLRRAPGAFFFFVFTSFILTLTMSMFFRSMASLSRSLVQVLPFSAVLLLGLSMYTGFAIPTGYMLGWARWIAYINPISYGFESLMINEFHNRDFPCMDYVPSGPGYTDVGLNNRVCSTVRSVPGQAFVNGNAYIESAYSYTASHKWRNIGVIFAYMFLLGAVYLVATDFITEKKPKGEILVFPRGHKALKKGKSDEDLEGGGGRSATVEKIGSDGLAMIERQTAIFQWKDVCFDIKIGKENCRILDHVDGWVKPGILTALMGVSGAGKTTLLDVLATRTTMGIISGEMLVDGQPRDESFQRKTGYAQQQDLHLSTATVREALEFSALLRQSAHVPRQEKIDYVTEVIKLLDMTEYADAVIGVPGEGLNVEQRKRLTIGVELAARPQLLLFLDEPTSGLDSQTSWAILDLLDKLKKNGQAILCTIHQPSAMLFQRFDRLLFLQAGGRTVYFGEIGQNSQILIDYFVRNGAPPCPPDANPAEWMLDVIGAAPGSHTSINWFETWRRSPEYARVQEHLAELKHERRHQTNLFRTTSGQKREDKDSYREFAAPFWAQLYQVQVRVFQQIWRSPTYINSKTALCVLSALFVGFSLFHTPNTIQGLQNQMFGIFMLLTLFGQLIQQIMPHFVAQRALYEVRDRPAKTYSWKAFLIANIVVELPWNSLMSVLMFLCWYYPIGLYRNAEPTDAVHLRGTQMWLMIWTFLLFSSTFAHFMIAAFDAAENAGNLGNLLFLLCLLFCGVLATPDQLPRFWIFMYRVSPFTYLVSGMLSVGISNTNVTCADNEYLRFDPVNGTCGEYMGSYMSNLGGYLADEMATANCSFCPIKETNVFLGRVSSSYSDIWRNFGLMWVFIVFNIFAACSLYWWVRVPRDKKPVAKAE
ABC transporter that seems not to be involved in the efflux of toxic substances, at least not the classical compounds such as itraconazole, amphotericin B, voriconazole, posaconazole, ravuconazole, or echinocandins.
Q8X170
Q5L407
RL7_GEOKA
50S ribosomal protein L7/L12
Geobacillus thermoleovorans group
MMTKEQIIEAVKNMTVLELNELVKAIEEEFGVTAAAPVVVAGGAAAGAEAAAEKTEFDVILADAGAQKIKVIKVVREITGLGLKEAKDLVDNTPKPIKEGIAKEEAEEIKAKLEEAGAKVEIK
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
Q5L407
P25497
3S11_PSEAU
Neurotoxin PA A
Pseudechis
MKTLLLTLVVVTIVCLDLGYTMTCCNQQSSQPKTTTICAGGESSCYKKTWSDHRGSRTERGCGCPHVKPGIKLTCCKTDECNN
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
P25497
C0ZA70
RNPA_BREBN
Protein C5
Brevibacillus
MHRSHRLKKNEQFQAVFQRGSSAANKQFVLYSAKQEGQAAFRAGISVSKKIGNAVVRNRVKRLIREAVARMESDIPVGLDLVIIARPGVEAMTLEAIEQSLLHVMKRAKVIKQAPVHNGKRDGKRG
RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
C0ZA70
Q6N1S9
AROE_RHOPA
Shikimate dehydrogenase (NADP(+))
Rhodopseudomonas
MAATKRAACLIGCPAAHSRSPLIHHYWLRQLGIEGGYSIEAVPPEGFAEFVLHLKTHGYVGANVTIPHKERALQLTEPDERACAVGAANTLYYDGDLLRSTNTDIEGFIGNLDASAPGWDRSAHALVLGAGGSSRAVVFGLLERGVQRIALANRSIERAQALRDLFGERVVPIAWSDIPAALPGAGLLVNTTSLGMKGQPPLQIDLSALPADAVVSDLVYVPLETDLLAAAKARGLRTADGLGMLLHQAVRGFDLWFGARPHVTPELRALVEADLAPK
Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
Q6N1S9
Q9RVD3
AROA_DEIRA
5-enolpyruvylshikimate-3-phosphate synthase
Deinococcus
MSDALPATFDVIVHPARELRGELRAQPSKNYTTRYLLAAALAEGETRVVGVATSEDAEAMLRCLRDWGAGVELVGDDAVIRGFGARPQAGVTLNPGNAGAVARFLMGVAALTSGTTFVTDYPDSLGKRPQGDLLEALERLGAWVSSNDGRLPISVSGPVRGGTVEVSAERSSQYASALMFLGPLLPDGLELRLTGDIKSHAPLRQTLDTLSDFGVRATASDDLRRISIPGGQKYRPGRVLVPGDYPGSAAILTAAALLPGEVRLSNLREHDLQGEKEAVNVLREMGADIVREGDTLTVRGGRPLHAVTRDGDSFTDAVQALTAAAAFAEGDTTWENVATLRLKECDRISDTRAELERLGLRARETADSLSVTGSAHLAGGITADGHGDHRMIMLLTLLGLRADAPLRITGAHHIRKSYPQFFAHLEALGARFEYAEATA
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
Q9RVD3
Q5R6J7
GPAT4_PONAB
Lysophosphatidic acid acyltransferase zeta
Pongo
MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYMKTLLKIFAWATLRMERGAKEKNHQLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDNTPEFELSDIFYFCRKGMETIMDDEVTKRFSAEELESWNLLSRTNYNFQYISLRLTVLWGLGVLIRYCFLLPLRIALAFTGISLLVVGTTVVGYLPNGRFKEFMSKHVHLMCYRICVRALTAIITYHDRENRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRAMVKACPHVWFERSEVKDRHLVAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAIKYDPQFGDAFWNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREADEDAVQFANRVKSAIARQGGLVDLLWDGGLKREKVKDTFKEEQQKLYSKMIVGNHKDRSRS
Converts glycerol-3-phosphate to 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) by incorporating an acyl moiety at the sn-1 position of the glycerol backbone. Active against both saturated and unsaturated long-chain fatty acyl-CoAs. Protects cells against lipotoxicity.
Q5R6J7
Q2PFD7
PSD3_MOUSE
Pleckstrin homology and SEC7 domain-containing protein 3
Mus
MEGRNAAAEPFVWVNSASAHSQSVAKAKYEFLFGKSEEKTPDSSDHGGSTLLPPTVTNEFPEYGTMEEGGEGLRASLDFDAKSPPCRLPGQQAVHLLAGQDSILNSVTEGPNDAPQCHPQEQSLQPIDSLISALKATEARIASGTFQATKVLDKDANFSVYQVDKELSTASHKPQRAHRTFPVGPGKSPDIPLSAEVPTEENLSLHIQEDLSALLPEEAQAHRSQITNYRRQGPLRVPESACPVSSSSAGSHNPVDRVGALREQRSDLGREHPRGYDRGGSMGRQGRIKHVEFQGVEILWTGEEAESRHPPERTASPVSKEFAKRPSHSSPACGVCSTSTHLTGDVWDETCKAPSERPGTSAGTLSPMPLGESGEDDVFLRESKEHLEENFAIQGDKERILDQEEHLRGDDDILGPGYTEDSTDVYSSQFETILDNTSLYYSAESLETLYSEPDSYFSFEMPLTPMIQQRIKEGGQFLERTSVGGQHDVLSVSADGGIVMGYSAGITNGLHDSANSVYTRGPQEIAFWGSRDRCFAEGKTTGVDAGSEMGSTDILEKETTESLSNGTNSNVEAAKRLAKRLYHLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFLKAFSLVGETQERERVLIHFSNRYFSCNPDTITSKDGVHCLTCAMMLLNTDLHGHVNIGKKMTCQEFITNLQGVNEGGDFSKDLLKALYNSIKNEKLEWAVDDEEKKKSPSEGTDEKANGTHPKTISRIGSTTNPFLDIPHDPNAAVYKSGFLARKIHADMDGKKTPRGKRGWKTFYAVLKGTVLYLQKDEYKPEKSLSDEDLKNAVSVHHALASKATDYEKKPNVFKLKTADWRVLLFQTQSPEEMQGWINKINCVAAVFSAPPFPAAIGSQKKFSRPLLPATTTKLSQEEQLKSHESKLKQITTELAEHRSYPPDKKVKAKDVDEYKLKDHYLEFEKTRYEIYVSVLKEGGKELLTTDGNEPVGLKKSHSSPSLNPDASPVTAKVKRNVSERKDHRPETPGIKQKVT
Guanine nucleotide exchange factor for ARF6.
Q2PFD7
Q98K73
TAM_RHILO
Trans-aconitate 2-methyltransferase
Mesorhizobium
MADWSAAQYLKFEDERTRPARDLVAQVPVDFPRRVVDIGCGPGNSTELLVQRWPDAQVSGFDTSPDMIEKARVRLPNVSFDLADASTWQPAEPVNVIFANAVFQWLPTHPAVFQRLMGFLAPGGALAVQMPDNLLEPSHQMMRDTAAEMPFADKLKGAARGPLPPVSFYYDLMSPLADRLDIWHTAYNHPLADAEAIVEWVKSTGLKPFLDPLDADERKMFLDSYTAKIAKAYPKTADGKVLLRFPRIFIVAKRAG
Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.
Q98K73
Q0HFZ0
LSPA_SHESM
Signal peptidase II
Shewanella
MPLTWKDSGLRWYWVVVLVFLADQLSKQWVLANFDLFESVKLLPFFNFTYVRNYGAAFSFLSEAGGWQRWLFTLVAVGFSTLLTVWLRKQSASLWKLNLAYTLVIGGALGNLIDRLMHGFVVDFIDFYWGKSHYPAFNIADSAIFIGAVLIIWDSFFNSKSEQDKTEEVK
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Q0HFZ0
Q92FU8
RECF_LISIN
DNA replication and repair protein RecF
Listeria
MHLESIVLRNFRNYENLELEFSPSVNVFLGENAQGKTNLLEAVLMLALAKSHRTTNDKDFIMWEKEEAKMEGRVVKRGQTVPLELAITQKGKRAKVNHLEQKKLSQYVGNLNVVIFAPEDLSLVKGAPGVRRRFLNMEIGQMQPIYLHNLSEYQRILQQRNQYLKMLQMKRKVDPMLLDILTEQFADVAINLTKRRADFIQKLEAYAAPIHHQISRGLETLKIEYKASVTLNGDDPEVWKADLLQKMESIKQREIDRGVTLIGPHRDDSLFYINGQNVQDFGSQGQQRTTALSVKLAEIDLIHEETGEYPVLLLDDVLSELDDYRQSHLLGAIEGKVQTFVTTTSTSGIDHNTLRQATTFYVEKGTVKKS
The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
Q92FU8
A0A0H3JT80
ODH_STAAM
Staphylopine dehydrogenase
Staphylococcus
MSKLLMIGTGPVAIQLANICYLKSDYEIDMVGRASTSEKSKRLYQAYKKEKQFEVKIQNEAHQHLEGKFEINRLYKDVKNVKGEYETVVMACTADAYYDTLQQLSLETLQSVKHVILISPTFGSQMIVEQFMSKFSQDIEVISFSTYLGDTRIVDKEAPNHVLTTGVKKKLYMGSTHSNSTMCQRISALAEQLKIQLEVVESPLHAETRNSSLYVHPPLFMNDFSLKAIFEGTDVPVYVYKLFPEGPITMTLIREMRLMWKEMMAILQAFRVPSVNLLQFMVKENYPVRPETLDEGDIEHFEILPDILQEYLLYVRYTAILIDPFSQPDENGHYFDFSAVPFKQVYKNEQDVVQIPRMPSEDYYRTAMIQHIGKMLGIKTPMIDQFLTRYEASCQAYKDMHQDQQLSSQFNTNLFEGDKALVTKFLEINRTLS
Catalyzes the NADPH-dependent reductive condensation of pyruvate to the intermediate formed by the adjacently encoded enzyme CntL, namely (2S)-2-amino-4-{[(1R)-1-carboxy-2-(1H-imidazol-4-yl)ethyl]amino}butanoate, leading to the production of staphylopine. This is the last step in the biosynthesis of the metallophore staphylopine, which is involved in the acquisition of nickel, cobalt, zinc, copper, and iron, and thus enables bacterial growth inside the host, where metal access is limited. Therefore, this enzyme probably contributes to staphylococcal virulence. Can use neither NADH nor alpha-ketoglutarate in place of NADPH and pyruvate, respectively.
A0A0H3JT80
Q9PMK3
TRUD_CAMJE
tRNA-uridine isomerase D
Campylobacter
MNLEEENTIFKPLYSLKHSPINAYFSKNSDDFVVRERPLYEFSGKGEHLILHINKKDLTTNEALKILSEASGVKIRDFGYAGLKDKQGSTFQYLSMPKKFESFLSNFSHPKLKILEIFTHENKLRIGHLKGNSFFIRLKKVLPSDALKLEQALMNLDKQGFANYFGYQRFGKFGDNYKEGLEILRGKKMKNVKMKEFLISAFQSELFNRYLSKRVELSHFANDFSEKELIQIYKISKEEAKELKKQEQFFKLLKGEVLGHYPFGKCFLCEDLSAELGRFKARDISAMGLLIGAKAYETGEGLALNLENEIFKDTLEFKAKMQGSRRFMWGYLEELKWRYDEEKAHFCIEFFLQKGSYATVVLEEILHKNLFE
Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Q9PMK3
Q606J9
UBIE_METCA
Demethylmenaquinone methyltransferase
Methylococcus
MSENTTHFGFRTVPEHEKANMVRAVFDSVAGKYDVMNDLMSIGIHRLWKRIAVDLAHVRSGEKVLDLAGGTGDLTALFRKRVGARGFVVLSDINAEMLRRGRDRIIDDGLAESVAYAQIDAEKLPFPHDSFDCISIGFGLRNVTHKDKALNSMYRALKPGGRLIVLEFSEVHNELLRKAYDLYSFKVLPFLGKLVANDAESYRYLAESIRMHPNQEKLKAMMEKAGFERCEYFDLMQGIVAVHRGYKF
Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).
Q606J9
A6Q596
DAPB_NITSB
4-hydroxy-tetrahydrodipicolinate reductase
unclassified Nitratiruptor
MLNVGIYGGSGRVGSLLIKNLQHDEVARVSVVHVLKGIELAVPGATVTNDIDTLIQKSDVIIDFTLPEGTESLLERLLEHPKPLVSGTTGLNKHQQNLMQTLAQKTPVLYATNMSLGIALLKRLVAVTSEKLRDFDIEIVEMHHRYKKDAPSGTALTLAEFAAKARGLDLEKVRVSGRDGNIGERSKEEIGVFALRGGDIVGRHTVGFYNDGEYIELNHTATSRDTFAKGAIKAAKWLVSQEPGFYTIDDCLGL
Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
A6Q596
Q6MT06
DNAK_MYCMS
Heat shock protein 70
Mycoplasma
MAKEKIIGIDLGTTNSVVSVIEGGQPIILENPEGQRTTPSVVAFKNSDIIVGGAAKRQAVTNPNVVQSIKSKMGTTSKVNLEGKDYSPEQISAEILRYMKNYAEAKLGQKVTKAVITVPAYFNDAQRKATKDAGTIAGLQVERIINEPTAAALAYGLDKQDKEETILVYDLGGGTFDVSILAIGGGSFDVIATSGNNKLGGDNFDEEIIKWLLGKIKAEYNIDLSKEKMALQRLKDEAEKAKINLSSQLEVEINLPFIAMNESGPISFATTLTRSEFNKITKHLVDLTIQPVKDALSAAKKTPSEINEVLLVGGSTRIPAVQELVKSLLNKEPNRSINPDEVVAMGAAVQGGVLAGEVTDILLLDVTPLSLGIETMGGVMTKLIERNTTIPAKRTQIFSTATDNQPAVDINVLQGERAMAADNKSLGQFQLTGIQPAPRGVPQIEVTFEIDANGIVSVSAKDKNTNEEKTITISNSGNLSEAEVERMIKEAQENAANDEVKKKNIELKNKAENYINIIENSLLQAGDKISAEQKEQSQKMVDEIKELVKNENYEALEQKMAELEQAMAQAAEFANKQNESDPNNNSSEQNN
Acts as a chaperone.
Q6MT06
A7GJZ2
MCSB_BACCN
Protein-arginine kinase
Bacillus cereus group
MSLDRIMNEAISPWMKGDGPDSDIVLSTRIRLARNLKNYHFPIMQTAEEANQITELFQQKLVNKTMRDFGSFELLKMNELTPLQRRVLVEKHLISPNLAETEFGACILSESEHISVMLNEEDHVRIQCLFPGLQLSEALQSANKIDNVFEEVVEYAFDEELGYVTSCPTNVGTGLRASVMIHLPALVLTKRINRIIQAIQQLGLVVRGIYGEGSEALGNIFQVSNQMTLGKSEEDIIADLTSVIHQLIQQEKAARELIVKNSSIELEDKVYRSYGILAHSRLIQSAEAATCLSDVRLGIDLGYIKDVSRNILTELMVLTQPGILQQYAGGQLGPEERDYRRAALIRERLRIEENEA
Catalyzes the specific phosphorylation of arginine residues in a large number of proteins. Is part of the bacterial stress response system. Protein arginine phosphorylation has a physiologically important role and is involved in the regulation of many critical cellular processes, such as protein homeostasis, motility, competence, and stringent and stress responses, by regulating gene expression and protein activity.
A7GJZ2
Q0D155
AT329_ASPTN
Isoflavipucine biosynthesis cluster protein ATEG_00329
Aspergillus subgen. Circumdati
MSPVKQRLLRIAVSHNRHPSLSEEQFHQWATKEHCARAARIHSRHGIEAYGMLFSPETARTTVQNLNRQLGGRWKIDEHDVTVEFYLHSLDELTSVLEDPEFKALQQEEEPYVSGEDIVATLGWVETYVQDGRVVNVDSEGVPTYPGFGVLADFSSEQVNQK
Putative oxygenase; part of the gene cluster that mediates the biosynthesis of isoflavipucine . The PKS part of the PKS-NRPS ATEG_00325 probably assembles a triketide from an acetyl starter and two malonyl-CoA extender units . The poly-beta-keto intermediate would then be fused to the leucine unit by the NRPS part . The resulting amide would be liberated from the PKS-NRPS through reductive release of the linear PKS-NRPS product from the enzyme complex . Further steps in isoflapucine synthesis include a cyclization step, an oxidation step, a hydrolysis step involving a trans-amidation, and an additional oxidation step, leading to flavipucine . Formation of isoflavipucine from flavipucine requires an unusual rearrangement . Alternative rearrangement reactions could build up rubrobramide, representing a branching of flavipucine biosynthesis . The enzymes involved in the post-PKS-NRPS steps have not been identified yet, but the putative oxygenases ATEG_003329 and ATEG_00330 encoded by the cluster could play a role .
Q0D155
Q74JN8
UVRC_LACJO
Excinuclease ABC subunit C
Lactobacillus
MATEHIENKLKLLPDKPGCYLMKDVNGNVIYVGKSKNLKNRVRSYFKSKQVGRRAELVREIRDFDIITVSSDKESFLLEITLIKKYQPYYNVQLKQGTGYPYIEITNERDPQTRLTSIVHKDHGYYFGPYPNVYAAQATLKFIQKVWPLRRCTGHQGRPCLYYHMGQCLGACFKEVPKSTYDAQIRKIKRFLNGDIAQVKQDLTEKMTQASMDLEFERAAEIRDQLKYIEQTVEKQKIISNDHTQRDIFNFYVDKSWISIQIFFLRQAKLLRRETRLFPLTDTNDPQDAFVSFIAQFYGQRNRVLPKEVLVPAGMDNESLSEVLKVPVRTPQRGQKKALLEMAHDNAKLKLDEKFRLLELGNRKTKGAQKEIFDALGLPYGHRIESFDHSHIQGADPVSALVVFTDGEADKHEYRKYKLKGEVEHQNAADEVGNTREVVRRRYSRLLKEHKKMPDLILMDGGQIQVEACLDVLRNELNVNIPVAGMVKDDHHRTNHLIFGDPTKGEELKLIPLDPKSEGFYLMTRIQDEVHRFAITFHRRTHAKNALSSKLDEIKGIGPKSRNKLLRKFGSLKKIKEASVDELREAGLTLPQAQTVKLSL
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q74JN8
G5EEL5
DBL1_CAEEL
Dpp and BMP-like protein 1
Caenorhabditis
MNDSVRTTTTISSTKSLVHSFQLSAILHLFLLISFTPMSAAADQHASHATRRGLLRKLGLEHVPVQTGPSIDVPQHMWDIYDDDNDVDWVRHYYPKEIIEDNEGFLLSYNLSLAARNAHNEEVTKATLKLRLRRNNKARRSGNISIYFFEDDINNDRFQIESRSVDNLTEWIDFDVTAAFLRRTNRISFFIDLPEDVEIEETQSSSLSSLPYARAQSAPLIVFSDLSEPSSVRRKRSAQTGNSERKNRKKGRKHHNTEAESNLCRRTDFYVDFDDLNWQDWIMAPKGYDAYQCQGSCPNPMPAQLNATNHAIIQSLLHSLRPDEVPPPCCVPTETSPLSILYMDVDKVIVIREYADMRVESCGCR
Ligand for the serine/threonine-protein kinase receptor type-1 sma-6 which activates a TGF-beta-like signaling pathway . Multifunctional protein that is involved in body size, male ectodermal patterning, innate immunity, lipid metabolism and neural plasticity . Dose-dependent regulator of body size, probably influencing the sizes of some or all cells rather than their number . Plays a role in patterning of male-specific genital sensilla (simple sense organs), known as rays, and mating-associated structures, spicules . Plays a protective role in response to infection by the Gram-negative bacterium S.marcescens, by activating expression of genes involved in innate immunity . Regulator of lipid homeostasis, acting non cell-autonomously in the hypodermis; partly dependent on the Insulin/IGF-1-like signaling (IIS) mediated pathway . Required for aversive olfactory learning of pathogenic bacteria in adults . Involved in gland cell morphology, possibly via activation of a Smad-independent TGF-beta signaling pathway . Required to oppose the autoregulation of expression of Runt-related transcription factor rnt-1.
G5EEL5
P77873
NIFH_HERSE
Nitrogenase reductase
Herbaspirillum
MASLRQIAFYGKGGIGKSTTSQNTLAALAQMGQRILIVGCDPKADSTRLILHAKAQDTILSLAADAGSVEDLELEDVMKIGYQNIRCVESGGPEPGVGCAGRGVITSINFLEEEGAYDDTDYVSYDVLGDVVCGGFAMPIRENKAQEIYIVMSGEMMAMYAANNISKGILKYANSGGVRLGGLICNERKTDKELELATALAAKLNSKLIHFVPRDNIVQHAELRRMTVLEYAPDSKQAGEYRTLANKIHENAGNGTIPTPITMDELEDLLMQHGLMPVVDESMVGKSAEVAA
The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.
P77873
Q6AAI8
NAGB_CUTAK
Glucosamine-6-phosphate isomerase
Cutibacterium
MEVIICSDEQAVGRIAADRIAKVLGRAKAPVLGVATGSTPLTTYSSLAALAAEGKADFTDLRAFALDEYIGLPADDERSYAATIRHTVTEQLGLDPANVHTPDGMADDLDAACAAYETAIQEADGVDVQILGIGANGHIGFNEPTSSLSSRTRVKTLAERTKADNARFFEEGEKVPSHCVTQGLGTIMDARNVVLLAIGANKADALAGAVEGPVSAMCPASVLQFHPHVLVIADDAAASKLTMAEYFRWTDSQRGDLSGAM
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
Q6AAI8
Q0SP20
YIDD_BORAP
Putative membrane protein insertion efficiency factor
Borreliella
MNIFKIFFILNYTIIFLIKIYQNTFSKLFGQQCIYKPTCSKYSIECLKKYNFLTALVLMTLRTIRCNALFKGGNDFIPKYNPISTSLKEFQKRLIK
Could be involved in insertion of integral membrane proteins into the membrane.
Q0SP20
P0AAK0
HYBA_SHIFL
Hydrogenase-2 operon protein HybA
Shigella
MNRRNFIKAASCGALLTGALPSVSHAAAENRPPIPGSLGMLYDSTLCVGCQACVTKCQDINFPERNPQGEQTWSNNDKLSPYTNNIIQVWTSGTGVNKDQEENGYAYIKKQCMHCVDPNCVSVCPVSALKKDPKTGIVHYDKDVCTGCRYCMVACPYNVPKYDYNNPFGALHKCELCNQKGVERLDKGGLPGCVEVCPAGAVIFGTREELMAEAKKRLALKPGSEYHYPRQTLKSGDTYLHTVPKYYPHLYGEKEGGGTQVLVLTGVPYENLDLPKLDDLSTGARSENIQHTLYKGMMLPLAVLAGLTVLVRRNTKNDHHDGGDDHES
Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover.
P0AAK0
P83142
AFP2S_MALPA
CW-2
Malva
SDYSRKRDPPQKYEEE
Possesses antifungal activity against P.infestans but not F.graminearum.
P83142
A4QBJ1
RS17_CORGB
30S ribosomal protein S17
Corynebacterium
MSEANVNNQEKSTRKVRTGYVVSDKMQKTIVVEVEDRKQHALYGKILRSAKKVKAHDEEQIAGIGDLVRIEETRPLSKDKNYRLIEIVEKAK
One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
A4QBJ1
A9MFP1
MIAA_SALAR
Isopentenyl-diphosphate:tRNA isopentenyltransferase
Salmonella
MNDVSKASLPKAIFLMGPTASGKTALAIELRKVLPVELISVDSALIYRGMDIGTAKPSADELKAAPHRLLNIRDPSQAYSAADFRRDALAQMAEITAAGRIPLLVGGTMLYFKALLEGLSPLPSADPEVRSRIEQQAAELGWELLHQQLQEIDPVAAARIHPNDPQRLSRALEVFFISGKTLTELTQTSGDALPYQVHQFAIAPASRELLHQRIELRFHQMLASGFEAEVRALFARGDLHTDLPSIRCVGYRQMWSYIEGEISYDEMVYRGVCATRQLAKRQMTWLRGWEGVRWLDSENPDRARKEVLQVVGAIAD
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).
A9MFP1
A1AW13
GATA_RUTMC
Glutamyl-tRNA(Gln) amidotransferase subunit A
Candidatus Ruthia
MHTKTIVELAQGFKDKDFSCVELTQYYLNRIDQSDLNAFITVTDELALAQAQVADDKIASGNANILTGIPYAHKDIFCTKGVKTSAGSRMLDTFVSPYDATVSQKLNQVNLVMLGKTNMDEFAMGSSNENSFYGAVKNPWNYLKIPGGSSGGSAASVAGGLSCFATGTDTGGSIRQPASLCGITGIKPTYGRISRYGMIAYASSLDQAGPMTKTAQDAAIVLNVMAGFDEKDSTSVEQKVPDYTTHLNDSIKGLIIGLPKEFFSSGLDDEVANNIMAAVKEFEAMGAIVKEVSLPNLAYAIPVYYIVAPCECSSNLSRLDGVRYGYRAKNVKNLEDLYLRSRSEGFGEEVKRRIMIGAYALSAGYYDAYYLKAQKVRHLISDDFKKVFEQIDVIMGPVSPTTAFDLGSVKDPVSMYLADIYTLSANLAGLPGMSIPAGFAQNLPVGLQLIGNFWSESRLLNIAHQFQLQTDWHLKTPQEC
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
A1AW13
Q1CWZ9
CHEB5_MYXXD
Protein-glutamate methylesterase/protein-glutamine glutaminase 5
Myxococcus
MTVVSPIRVLVVDDSAFARKVLRQVLSSAEGLEVVGVARDGLDALEKVAELSPDVLTLDLVMPGLDGLGVLRALASSAAAPRVVVVSSAGEESELAVAALQAGAVELVNKPTALATERLYELGGELVAKVRTAAGAVARAPPEPAPSPEATSAPVARAAAKSLVVVGTSTGGPQALTRLLSELPVDFPAPLALALHIPTGYTEAVARRLNAHCALEVFEAVDGLELRPGRVVLARSGQHLKLERHGPVTLARLDRQPLRTAHHPSVDVLFESAARSWGSDVVGLVLTGMGDDGVAGARAIREAGGTVLTESESSCVVYGMPRAVKEAGLATDSAPLEGMLALLRRHVR
Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
Q1CWZ9
B7VMW3
HEM6_VIBA3
Oxygen-dependent coproporphyrinogen-III oxidase
Vibrio
MSAIDKEAVKQFLLSLQDSICQQLEQADGTALFEEDAWQREPGERLGGGGRTRVMTNGAVFEQGGVNFSHVAGKAMPASATAHRPELAGRKFEAMGVSLVIHPKNPYIPTSHANVRFFIAEKEGEDPIWWFGGGFDLTPFYPVDEDCQSWHQTAKDLCAPFGDDVYQEHKEWCDKYFYLPHRDETRGVGGLFFDDLNEWGFEKSFAYMQAVGEGFAAAYLPIVERRKETPYGERERDFQLYRRGRYVEFNLVYDRGTLFGLQSGGRTESILMSMPPLARWEYRYEPQACSPEALLYSDYLKPRVW
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
B7VMW3
A2VDZ9
VAPB_BOVIN
Vesicle-associated membrane protein-associated protein B
Bos
MAKVEQVLSLEPQHELKFRGPFTDVVTTNLKLGNPTDRNVCFKVKTTAPRRYCVRPNSGIIDAGASINVSVMLQPFDYDPNEKSKHKFMVQSMFAPTDTSDMEAVWKEAKPEDLMDSKLRCVFELPAENDKPHDVEINKIIPTTASKTETPTVSKALSSSLDDTEVKKVMEECKRLQSEVQRLREENKQFKEEDGLRMRKTAQSNSPAPASAMAGKEEGLSTRLLALVVLFFIVGVIIGKIAL
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
A2VDZ9
Q9JIH2
NUP50_MOUSE
Nucleoporin Nup50
Mus
MAKRVAEKELTDRNWDEEDEVEEMGTFSVASEEVMKNRAVKKAKRRNVGFESDSGGAFKGFKGLVVPSGGGGFSGFGGSGGKPLEGLTNGNSTDNATPFSNVKTAAEPKAAFGSFAVNGPTTLVDKKISSPKCNNSNQPPSSGPASSTACPGNAYHKQLAGLNCSVRDWIVKHVNTNPLCDLTPIFKDYERYLATIEKQLENGGGSSSESQTDRATAGMEPPSLFGSTKLQQESPFSFHGNKAEDTSEKVEFTAEKKSDAAQGATSASFSFGKKIESSALGSLSSGSLTGFSFSAGSSSLFGKDAAQSKAASSLFSAKASESPAGGGSSECRDGEEEENDEPPKVVVTEVKEEDAFYSKKCKLFYKKDNEFKEKGVGTLHLKPTATQKTQLLVRADTNLGNILLNVLIAPNMPCTRTGKNNVLIVCVPNPPLDEKQPTLPATMLIRVKTSEDADELHKILLEKKDA
Component of the nuclear pore complex that has a direct role in nuclear protein import . Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling . Interacts with regulatory proteins of cell cycle progression including CDKN1B . This interaction is required for correct intracellular transport and degradation of CDKN1B .
Q9JIH2
O58739
SYY_PYRHO
Tyrosyl-tRNA synthetase
Pyrococcus
MDIEERINLVLKKPTEEVLTVENLRHLFEIGAPLQHYIGFEISGYIHLGTGLMAGAKIADFQKAGIKTRVFLADWHSWINDKLGGDLEVIQEVALKYFKVGMEKSIEVMGGDPKKVEFVLASEILEKGDYWQTVIDISKNVTLSRVMRSITIMGRQMGEAIDFAKLIYPMMQVADIFYQGVTIAHAGMDQRKAHVIAIEVAQKLRYHPIVHEGEKLKPVAVHHHLLLGLQEPPKWPIESEEEFKEIKAQMKMSKSKPYSAVFIHDSPEEIRQKLRKAFCPAREVRYNPVLDWVEYIIFREEPTEFTVHRPAKFGGDVTYTTFEELKRDFAEGKLHPLDLKNAVAEYLINLLEPIRRYFEKHPEPLELMRSVKITR
Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
O58739
Q8CS66
ACCD_STAES
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Staphylococcus
MFKDFFNRSKKKKYLTVQDSKQNDVPAGIMTKCPKCKKIMYTKELNENLNVCFNCDHHIALTAYKRIEAISDEGSFIEFDRGMTSANPLDFPGYEEKIEKDQQKTGLNEALVSGTAKLDGIQYGVAVMDARFRMGSMGSVVGEKICRIIDYCTEHRLPFILFSASGGARMQEGIISLMQMGKTSVSLKRHSDAGLLYISYITNPTTGGVSASFASVGDINLSEPKALIGFAGRRVIEQTINEKLPDDFQTAEFLLEHGQLDKVIHRKDMRETLSNILKIHQEVSN
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
Q8CS66
Q21389
LGE1_CAEEL
Glycosyltransferase-like protein LARGE
Caenorhabditis
MQSNYSISYFLLILFTGTSSYFTIWNFVDHTRVGAFPEEDYIRLAYIIGGNFMTRLMFMQHFKSVLKYSDHFFRLHLITDENHRSDIHELMTSWNISNCEWFFHNLTEFEKRVAWIPNSHYSKYYGLSKLLIPEIIGNDIGKIMFMDVDIIFQTNIFDLWKQFRNFNNSQVFGMVENLSDWYLNKDGKKSVWPALGRGFNTGIIMFDLDKLRKNGWASKWRVVANKYLRIHGKTAMSDQDIFNAYIHDYPTEIIQIPCAYNYQLGALTKSKELCPETPLALHFNSQNKTVGKNYAFFDKIRKAFDEMDGSDLKRRRRSFKGNNQKDICHEYLPLDNFRIIPNAIGRMTKPAELCMVTQFSKDRLNHFLESANAWRHPISTAVYGKDKDLLDIAKAVTELNRTDITIHLVFEEPTESWMLDSLYPINFLRNVAIEHANCKYILMTDVDFVVLGDYGTIIDQTGNLKQKEVLVIPALEMTYPQLRLNLSNFLSRKDLVIEHLLNKTIQTFRETIWPSSHVPTNISKWIKSNRTYMVNYEKNYEPYFVIKKEECPFYDQRFGGFGWNKVTHVMQLKMMNYKFLVSPTSFMIHQNHNASKSLKRWRRDPHYQKCLHTLKNKFMKKTASRLGIKLR
Probable glycosyltransferase.
Q21389
Q5N1P5
TIG_SYNP6
PPIase
Synechococcus
MSIKVTQEKLPASRVGLQIEVSGEQSRQVYERTLTRLSREVRFPGFRPGKVPRPVLIQRLGETALKANAIEDLVQQSLESAIAQESIPAIGNYQLSSDFETLVAAFQPGKSFSFEASVDVQPTATLAQYTGLTVEVAEVPFDANRVDNVLAEQQKQMATLVPVEGRNAAIGDVAVIDFQGILVESGEEIPGGSGTDFQIEVEEDRFIPGFISGIVGMAIEETRTVDATFPETYAQEEVAGKAAQFTITLKELKTRDLPELDDAFAQEASQYETIEELKTALTERFQAEHESEVKASKRDAILTALADQLDVEIPESLLQREISAMINETASRLSGQGMDVRKLFTEEVLERLRENSKDEDEQRLRRTIALGELAKVTETQVDDEAVKARAAELLSNYPRPQEVDRDRLITVVREELLEDKLLEWFEANNSVTFVAPKAAETEVDAASATVETTATETAEEAPEAPKAKKGKKKA
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Q5N1P5
C8V4J7
DBAC_EMENI
Derivative of benzaldehyde biosynthesis cluster protein C
Aspergillus subgen. Nidulantes
MAQLYDWLVETPANAEDLESRINTRPAHLEHNKPLIEAGTLVWGGPSLAAHPKAAGEDLAIVGSVMCIRAGSEEEVREMIRNDPYAKLGQVSIRMSVK
Part of the gene cluster that mediates the biosynthesis of the antibiotic 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA) and its derivatives . The direct non-reducing polyketide synthase dbaI product is 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde (DHMBA), produced by condensation of one acetyl-CoA starter unit with 4 malonyl-CoA units and one methylation step . The FAD-dependent monooxygenase dbaH is responsible for the synthesis of yellow pigments derived from the oxidation of DHMBA . The roles of dbaB, C, E and F have still to be determined (Probable).
C8V4J7
Q8XL16
CBID_CLOPE
Cobalt-precorrin-6A synthase
Clostridium
MFDMYIESGGKKLRCGYTTGSCAAAAAKAATYMLFNKKDISVIEIDTPKNIKLNLEIQDIQVEKNSISCSIVKDGGDDIDATSGLEIFAKAEEVEEGFELCGGEGVGVVTKEGLFVEKGQPAINPVPREMIKKEVLSVLPKDKGVRITIFVPRGREIAKKTFNPRLGIVNGISILGTTGIVYPMSEEALKESIRIEIRQKAVNNKDLVFVFGNMGERFLRERGYKKDNIVVISNYVGFSIECALAQGIKDLTIVGHIGKLSKIAFGCFNTHSRVSDVRLEVIALELTLMGYDLELVQKVLDQKTSEGAVRLLGEDFPMLYERIGEKVLNRLDIYAYGEANFNILMYYGSKEMKLLYESKNSNLFD
Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
Q8XL16
Q1IS49
ATP6_KORVE
F-ATPase subunit 6
Candidatus Koribacter
MPHQLWFTAFLNQYLAGPVSAMMSVLHVPNPHPRAPISNYVAMEILVFLLLVLFFIATRISLSWDKPGVLQHIAEGMNNFVSNQGEEMIGHGYETYTSYIVTLGVFILSMNLIGLIPGFEAPTAFPSVPLGCALVTWFFYHVHGLRENGVIGYLKHFLGPVWWISPLLFVIEICSHFARIMSLTIRLYANMFAGDMVTLAFFSLVPLGFPVVFMGLHIFVSLIQTYIFITLAAVYLAEATAHGHD
Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.
Q1IS49
P43666
EPTB_SALTY
Phosphoethanolamine transferase EptB
Salmonella
MRYIKSMTQQKLSFLLALYIGLFMNCAVFYRRFGSYAQEFTIWKGLSAVVELGATVLVTFFLLRLLSLFGRRVWRVLATLVVLFSAGASYYMTFLNVVIGYGIIASVMTTDIDLSKEVVGLHFVLWLIAVSVLPLIFIWSNHCRYTLLRQLRTPGQRFRSAAVVVLAGVMVWAPIRLLDIQQKKVERATGIDLPSYGGVVANSYLPSNWLSALGLYAWAQVDESSDNNSLINPARKFTYVAPKDGDDTYVVFIIGETTRWDHMGIFGYERNTTPKLAQEKNLAAFRGYSCDTATKLSLRCMFVREGGADNNPQRTLKEQNVFAVLKQLGFSSDLYAMQSEMWFYSNTMADNISYREQIGAEPRNRGKTVDDMLLIDEMQNSLAQNPEGKHLIILHTKGSHFNYTQRYPRSYAQWKPECIGVDSGCTKAQMINSYDNSVTYVDHFITSVFDQLRDKKAIVFYAADHGESINEREHLHGTPRNMAPPEQFRVPMLVWMSDKYLASPQHAQMFAHLKQQAEIKVPRRHVELYDTIMGCLGYTSPNGGINQNNNWCHIPDVQKVAAK
Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid A. Phosphatidylethanolamines with one unsaturated acyl group functions as pEtN donors and the reaction releases diacylglycerol.
P43666
A3QIM9
RSMH_SHELP
rRNA (cytosine-N(4)-)-methyltransferase RsmH
Shewanella
MTQEFAHLSVLLTETVAGLNIKPEGIYIDGTFGRGGHSREVLKQLGPNGRLIAIDRDPQAIAAAEQFADDARFSIVHGGFGQLAQYVDDLGLRGKIDGILFDFGVSSPQLDDAERGFSFLRDGPLDMRMDNSQGETAAEWLARAEIEDMAWVFKTYGEEKNARHIARCIAADRDKTPFLRTKELADLIARVSKSKERNKHPATRVFQAIRIYINSELEQIDQALEGAVTVLAPQGRLSVISFHSLEDRMVKRFIRRHSQGESVPHGLPLTEAEINKTRLLKAVGKAIKPSAEEIDRNARARSSVLRVAERLDY
Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
A3QIM9
A8FH04
AMPA_BACP2
Leucyl aminopeptidase
Bacillus
MFFSTNELQHKDTLAIGLFQKSQLSGKAKEMDELLEGRITELLKEGDISSKRNQLSKFFPSPETGIKRIYFVGLGKESDYTFEEAKEGFAHLFRKLHQDKKQAVSVLLDTFIGKDLPAQDAAHTLSESCLLATYELQDFKHKTNEPDRFIEFVYAMTDHDTTEIQASLKVGEVYGQSVNSARTLVNMPPNMLTSSDLASYAAELAYKYEFEIEILDKEQMEELGMGGILAVNRGSTEPPKLIVLKYQGKEEWTDVIGLVGKGITYDTGGYSLKPRASMIGMKTDMGGSASVLGAMEIIGELRPEQNVIAVIASTDNMISADAMKPDDVIVSLSGKTIEVLNTDAEGRLVLADGVTYAKQHGASVLIDVATLTGGVIVALGNETTGVMTNNDELYAQFKEASEECGEMIWQLPITEKDKKRVRNSKMADLNNSPGRDGHAIMAGAFIGEFAENTPWVHLDIAGTATTEKPSCFGPTGATGVMVRSLATFVERFEGKK
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
A8FH04
Q15QR7
PYRG_PSEA6
UTP--ammonia ligase
Pseudoalteromonas
MTNYIFVTGGVVSSLGKGIAAASLAAILEARGLNVTMLKLDPYINVDPGTMSPIQHGEVFVTDDGAETDLDLGHYERFIRTRMTKRNNFTTGRVYEEVIKRERRGDYLGATIQVIPHITNEIKRRIIAGAEGVDVAIVEIGGTVGDIESQPFLEAIRQLGTEVGRDHAMYMHLTLVPYIAVSGEVKTKPTQHSVKELRSIGIQPDILVCRSENALPSNERSKIALFTNVADKAVISLKDANSIYKIPAALKAQGMDELVVQRFGLECPEADLTEWEQVLYAESNPVGEVTIGMVGKYVELPDAYKSVNEALKHAGLKNRLTVNIRYVDSQDIESKGEQILHGLDAILVPGGFGERGIEGKIAAAKYAREQKVPYLGICLGMQVAIIEFARNVAGMESANSSEFDPQTPYPVVGLITEWLDADGSTAQRSEASDLGGTMRLGSQLCHLIPGSKVHDLYGSAEIYERHRHRYEVNNNLRDKLEASGLKVTGLSTDKRLVEVIELGDHPWFVAGQFHPEFNSTPRDGHPLFEGFVKAAGEYYKNNN
Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
Q15QR7
B2U826
PDXH_RALPJ
Pyridoxal 5'-phosphate synthase
Ralstonia
MTSIADIRTDYARASLDIADVDASPLRQFRRWFDEALKAEVAEVNAMTLATVDPHGQPSARIVLLKNLDERGFTFFTNYASHKGEELAANPRAALLFHWIGLERQVRVQGIVEKVSEAESDAYYHSRPLGSRLGAWASEQSSEVPDRATLEAREAEYRQRFGDAPPRPPHWGGYRLLPERLEFWQGRPSRLHDRLEYRKHADGSWTIVRLAP
Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
B2U826
C0ZB50
PRMA_BREBN
Ribosomal protein L11 methyltransferase
Brevibacillus
MKWSEISIHTTAEATEAVSSLLYELGANGVVIEDPEVLYREWDTPFGEIYQLSPDDFPAEGVFVKAYLPVDSSELLDVVEELKEQLAQLIEYGLDIGKASIAVNDVHEDEWAHAWKKYYKPVHVSDRMTIKPVWEEYVPKHPDEIIIEMDPGMAFGTGTHPTTILCLRALEKYMAKGDQVYDVGTGTAILSIAAIKLGAKDVLAMDLDEVAVRSAQANTELNGVHEHINVRQNNLLDGIEEQVEVVVANILAEVIVRFTDDVFRVLKPGGTFISSGIIAAREADVKAALVASGLEIVETIFIDDWVAIVAKKR
Methylates ribosomal protein L11.
C0ZB50
Q3K5Z2
RS19_PSEPF
30S ribosomal protein S19
Pseudomonas
MPRSLKKGPFIDLHLLKKIEVAAEKNDRKPIKTWSRRSMILPQMVGLTIAVHNGRQHVPVLVNEDMVGHKLGEFAGTRNYRGHVADKKAKR
Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.
Q3K5Z2
Q1LX49
DEN11_DANRE
Protein LCHN
Danio
MVEQSDRAPLLDWEEIPPAELAPSVPSPDTGDSLQSGLSSYPTEATLGADITLNTSPTRPSSVAAVHSPHKQHSGPGGDALAEEDEPGDCAFHGLSVRDRRITGWEEKDQIVAVFVVTFDTRSGNMIEWCLPHDVNLEGVEFKSMASGSHRISSDFIYFRKGCYFGLACFANMPVESELERGARMKSVGILSPSYTLLYRYMHFLENQVRHQLQCPGQYSPLEAFYEDKKAVLPSGGNGLVTACPTSALAPIVNRCMHPEMKITHPAGCMSQFIRFFGEQIMVLWKFALLRKRILIFSPPPVGVVCYRVYCCCCLANVSIPGMGVSVPEFRPFFYINVADIPALETELSYVACTTEKIFEEKKELYDVYIDNQNVKTHRESLQPLLRLNSADREKYRKLCEQRQLLLYSQEVDGDCTSNEEDLFILFFMEQNNRIFQTLSEVAVSADPTLTAEHVRAMGLDPQGDRGFLVDLLEIYGIDVMLVIDNPCCP
Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form.
Q1LX49
P81765
POI_MUSDO
Phenoloxidase inhibitor
Musca
AVTDNEIVPQCLANGSKCYSHDVCCTKRCHNYAKKCVT
Potent reversible, competitive inhibitor of tyrosinase (phenol oxidase) in the nanomolar range.
P81765
Q3J0R1
SYA_CERS4
Alanyl-tRNA synthetase
Cereibacter
MPSLNDIRSTFLDYFRRNGHRVVESSPLVPRNDPTLMFTNSGMVQFKNCFTGLEHRDYTRATTAQKCVRAGGKHNDLDNVGYTARHHTFFEMLGNFSFGDYFKSDAIPFAWELLTKDFDIPKEKLLVTVYHTDDEAAEIWKKVAGLPDERIIRIPTNDNFWMMGPTGPCGPCTEIFFDHGPSIWGGPPGSADEDGDRFIEIWNLVFMQNEQHPDGSMTPLPKQSIDTGMGLERIGALLQGKHDNYDTDLMRSLIEASAHATSTDPDGPGKTHHRVIADHLRSTSFLIADGVMPSNEGRGYVLRRIMRRAMRHAHLLGAQDPVMHRLVPALVRQMGAAYPELTRGQALIEETLKLEETRFRQTLERGLRLLEDELGHLPEGSPLPGEAAFKLYDTYGFPLDLTQDALREKGRKVDVEGFEAAMAEQKAKARASWSGSGETKDAAIWFDLAETHGATEFLGYDTEQAEGQVLALVAAGAETASAGAGQTVQIILNQTPFYAESGGQVGDTGELRTDTGRARITDVKKGQGLFLHFAEVVEGEIRQGQGATLVVDHARRSAIRANHSATHLLHEALRRALGDHVAQRGSLNAPDRLRFDFSHSRALSPEELAAVEAEVNGFIRSNGAVETRIMSPDDARALGAQALFGEKYGDEVRVVSMGTLAGSGKGTDGQTYSLELCGGTHVSRLGDIGLCVILGDSASSAGVRRIEALTGEGALAYLNEQMKRLTDVAAALKAAPAELVDRVKALVEERRQLQNEVAQLRREAAMGGGAASEAKEIGGVKFLAQVVQGVPGKDMPGLIDEMKARVGSGAVLLISDTGGKAALAAGVTPDLTDRLSAVTLVKAAAEALGGRGGGGRPDMAQAGAADASQADAAIRAAEAVMGG
Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
Q3J0R1
Q90ZH8
SX18A_XENLA
SRY (sex determining region Y)-box 18A
Xenopus
MHRSESSYCREETTLCQGVNSTWVPPADTVPEVSLIPSSPPAPDSPAPSPKPGYGFSTCEEKHGDPRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGQSWKNLTSVEKRPFVEEAERLRVQHLQDHPNYKYRPRRKKQAKKLKRMDPSPLLRNEGFTRGQPMVNLSHFRNLHPLGGSGELESYGLPTPEMSPLDVLEPSEPAFFPPHMREDTDPVPFRTYQHGMDFSQEKTMREISLPYSSSPSHMGSFLRTPTPSAFYYKAHGGSPVCTPLGQLSPPPEAPALDAMDHLNQAELWGDFDRNEFDQYLNMSRTQRPGYSFPMSKLGAPRTIPCEENSLISALSDASTAMYYTPCITG
Probable transcription factor. Binds to the consensus DNA sequence 5'-AACAAT-3'. Also binds 5'-CACAAT-3' and 5'-AATAAT-3' with similar affinity.
Q90ZH8
Q6LN48
SYP_PHOPR
Prolyl-tRNA synthetase
Photobacterium
MRTSNYLLSTLKETPNDAEVISHQLMLRAGMIRKLASGLYTWLPTGLRVLRKVENIVRQEIDNAGAVEILMPVVQPFELWEETGRSEKMGPELLRFTDRHSRPFVLSPTAEEVVTSLVRNEISSYKQLPLNLYQIQTKFRDERRPRFGVMRAREFSMMDAYSFDIDKEGLEKSYQAMHDAYCKAFDRMGLEYRPVLADSGAIGGSGSQEFHVLAESGEDLIAFSSDSDYAANIEKAEALAPTAELAAATQEMELVDTPNAKTIAELVEQHGLAIEKTVKTLFVKASDEIDADIVALIIRGDHELNEVKAENLPQVASPLEMAEEAEIRALIGAGPGSLGPVGLELPFIVDRTVAIMSDFGAGANVDGKHYFGINWGRDVELAQVEDLRNVVEGDLSPCGQGTIQLKRGIEVGHIFQLGTNYSKKMNCNVLGPDGKSATLEMGCYGIGVSRIVASAIEQNNDENGIIWPTALAPFQVAIVPMNMAKSEEVKAAAESLYAELTAAGIEVLFDDRKERPGVMFKDIELIGIPHTIVIGNRSLENGEMEYKDRRDGNKVAVPVADVVEMIKQKLA
Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.
Q6LN48
B8ZSC6
RPOC_MYCLB
Transcriptase subunit beta'
Mycobacterium
MLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITTVDEEMRHNELSTLEAEMMVERKSVEDQRDADLEARAQKLEADLAALEAEGAKADARRKFRDGGEREMRQLRERAQRELDRLEDIWSTFTKLAPKQLIVDENLYRELVDRYGEYFTGAMGAESIQKLMQDFDIEAEAESLREVIRNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPDIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTTAVDGDTGAYRPAAEDRPESGVYSSPAEAIMAADRGVLSVRAKIKVQLTQVRPPADIEARWFGANGWRPGDPWIADTTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQRGALNHDERNEALVEIWKEATDEVGQALRDHYPVDNPIITIVDSGATGNFTQTRALAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAVRVPDGSLIRELYIETSAYARTLGANAVDEAGNVIVARGEDLGDPEIDALLAAGITQVKVRSVLTCTTGTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPDDGGEEVVYDKLSKRQRLRVFKHADGSERVLSDGDYVEVGQQLMEGSADPHEVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIDRAEFESENRRVVAESGEPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRYRNIQVQPTEEARASAYTIPSYEDQYYSPDFGQATGAAVPLDDYGYSDYR
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
B8ZSC6
Q0SZ21
METE_SHIF8
Methionine synthase, vitamin-B12 independent isozyme
Shigella
MTILNHTLGFPRVGLRRELKKAQESYWAGNSTREELLTVGRELRARHWDQQKQAGIDLLPVGDFAWYDHVLTTSLLLGNVPPRHQNKDGSVDIDTLFRIGRGRAPTGEPAAAAEMTKWFNTNYHYMVPEFVKGQQFKLTWTQLLEEVDEALALSHNVKPVLLGPVTYLWLGKVKGEQFDRLSLLNDILPVYQQVLAELAKRGIEWVQIDEPALVLELPQAWLDAYKPAYDALQGQVKLLLTTYFEGVTPNLDTITALPVQGLHVDLVHGKDDVVELHKRLPSDWLLSAGLINGRNVWRADLTEKYAQIKDIVGKRDLWVASSCSLLHSPIDLSVETRLDAEVKSWFAFALQKCHELALLRDALNSGDTAALAEWSAPIQARRHSTRVHNPAVEKRLAAITAQDSQRANVYEVRAEAQRARFKLPAWPTTTIGSFPQTTEIRTLRLDFKKGNLDANNYRTGIAEHIKQAIVEQERLGLDVLVHGEAERNDMVEYFGEHLDGFVFTQNGWVQSYGSRCVKPPIVIGDISRPAPITVEWAKYAQSLTDKPVKGMLTGPVTILCWSFPREDVSRETIAKQIALALRDEVADLEAAGIGIIQIDEPALREGLPLRRSDWDAYLQWGVEAFRINAAVAKDDTQIHTHMCYCEFNDIMDSIAALDADVITIETSRSDMELLESFEEFDYPNEIGPGVYDIHSPNVPSVEWIEALLKKAAKRIPAERLWVNPDCGLKTRGWPETRAALANMVQAAQNLRRG
Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.
Q0SZ21
A1S4C0
RISB_SHEAM
6,7-dimethyl-8-ribityllumazine synthase
Shewanella
MHIVEGHIEAKSAKVAIVVSRFNSFVVESLLSGAIDTLKRFGQVSEDNITVVRVPGAFELPLAAKKVAASGKFDGIIALGAVIRGGTPHFDFVAGECNKGLAQVSLEFNTPVSFGVLTTDTIEQAIERSGTKAGNKGGEAALGLLEMVNVLNAIDKEL
Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
A1S4C0
A6MW01
RK3_RHDSA
50S ribosomal protein L3, chloroplastic
Rhodomonas
MIPGILGTKLGMTQIFDESGLAIPVTVIKAGPCILTQIKTQESDSYQAIQIGFSEVKESSLNKPLLGHLKKSQAPALKHLKEYRVKSVEGLEVAQKITLDSFEVGKTVSVSGKTIGKGFAGTVRRYSFTRGPMTHGSKNHREPGSIGQGSTPGKVHKGKKMAGRLGGKQSTIKNLEIVHVNTDNNILVVKGAVPGKKGNILSIQQEEI
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
A6MW01
Q8FU10
RECR_COREF
Recombination protein RecR
Corynebacterium
MFEGPLQDLIDELSRLPGVGPKSAQRIAFHLLNVDPDDITRLQDALGAVRDGVRFCRICCNISRDEVCRICNDSGRDRGLICVVEEPKDIQVIERTGEFRGRYHVLGGALDPLANVGPRELTISTLLQRIGGVLDDRELADSTPDTPLLDDKPQIHEVILATDPNTEGEATASYLARLLQDFPDLVVSRLASGMPLGGDLEFVDELTLSRALSGRLPL
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
Q8FU10
Q9G6G2
CYB_OCHHY
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Ochotona
MTNIRKNHPLMKIVNHSLIDLPTPSNISTWWNFGSLLGLCLVIQIITGLFLAMHYTSDTLTAFSSVTHICRDVNYGWIIRYLHANGASMFFICLFLHVGRGIYYGSYTYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFILPFIIAALVMVHLLFLHETGSNNPTGIISDADKIPFHPYYTVKDALGFLVLTTLLLTLVLFSPDLLGDPDNYTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALVLSIAILAIMPLLHTSKQRSMMFRPISQTLFWILVADLLTLTWIGGQPVEHPFIIIGQLASFLYFFLILILMPTCSLIENKLLKW
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q9G6G2
Q9ZKG4
GUAA_HELPJ
Glutamine amidotransferase
Helicobacter
MILVLDFGSQYTQLIARRLRESGIYAEIVPFFESVENIQKKAPKGLILSGGPASVYAKDAYKPSEKIFDLNLPILGICYGMQYLVDFFGGVVAYANEQEFGKAILEIVQNSVIFEGVKIKSLVWMSHMDKVIELPKGFTTLAKSPNSPYCAIESDKIFGLQFHPEVIQSEEGGKILENFALLVCGCEKTWGMQHFAQREIVRLKEKIANAKVLCAVSGGVDSTVVATLLHRAIKDNLIAVFVDHGLLRKNEKEKVQAMFKDLQIPLNTIDAKEVFLSKLKGVSEPELKRKIIGETFIEVFEKEAKKHHLKGKIEFLAQGTLYPDVIESVSVKGPSKVIKTHHNVGGLPEWMDFKLIEPLRELFKDEVRLLGKELGVSQDFLMRHPFPGPGLAIRILGEINENKIKRLQEADAIFIEELKKANLYDKVWQAFCVLLNVNSVGVMGDNRTYENAICLRAVNASDGMTASFSFLEHSFLEKVSNRITNEVNGINRVVYDITSKPPGTIEWE
Catalyzes the synthesis of GMP from XMP.
Q9ZKG4
P0DJ63
VKT_OXYMI
Kunitz-type serine protease inhibitor OMI
Oxyuranus
KDFCHLPPKPGPCRAAI
Serine protease inhibitor that inhibits plasma kallikrein (Ki=1.7 nM), and plasmin (Ki=33.0 nM).
P0DJ63
Q7WP62
MODC_BORBR
Molybdenum import ATP-binding protein ModC
Bordetella
MPSDFPPGQAGIHARFRVDYPEFSLDVDLRLPGRGVTALFGQSGSGKTTCLRCMAGLAPVSDGYLDINGEVWLDSAARRAVPTHKRALGYVFQEASLFEHLDVLANLRYGMKRVPPALRRVDLEQATGLLGIGHLLARMPAGLSGGERQRVGIARALLTSPRLLLMDEPLAALDVQRKREILPYLERLHDELDIPVIYVSHSPDEVARLADHLVLLEQGRAVASGPLDALLTRLDLPMAMTDDASVVVTGEAAGFDPGYALLTLQLPGGRARLRFVHQAAPAGQRLRVVVHARDVSLALQQPREGSILNVLAVRVLEMAPAANPAHVMVRLDADGTPLLARITRYSRDRLALAPGMQAWAQIKAVSLLA
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.
Q7WP62
A5CUT3
RL1_CLAM3
50S ribosomal protein L1
Clavibacter
MAKSKAYRAAAEKIDPAKAYTASEAVELARETGSSKFDSTVEVALKLGVDPRKADQMVRGTVILPHGTGKTARVIVFATGPAAEAAIAAGADEVGGDELIEKVAGGYTSFDSAVSTPELMGKVGRLGKVLGPRGLMPNPKTGTVTPDVARAVSDIKGGKIEFRVDKHANVHFVVGKASFSPEQLSENVGAALEEIVRLKPSSSKGRYVQKATVSTTFGPGIPVDVNSI
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
A5CUT3
Q5ZJ56
RL7_CHICK
60S ribosomal protein L7
Gallus
MADKEAKKVPSVPESLLKRRQAYAAAKAKRLKRLLAQKKFRKAQRKIIYERAKAYHKEYRHMYRQEIRMARMARKAGNYYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVHDLIYKRGYGKINKKRIALTDNSLIRKRLGKLGIICMEDVIHEIYTVGKNFKVVNNFLWPFKLSSPRGGMKKKTIHFVEGGDAGNREDQINRLIRRMN
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
Q5ZJ56
A5EKH8
NUSB_BRASB
Antitermination factor NusB
unclassified Bradyrhizobium
MAESSNKPFRGPVRANDRKANRRGAARLAAVQALYQMDIAGAGINDVLAEFESHWLGSEVEGEQYLPAEAAFFRDIVSGVVRDQTKIDPVLDTALERGWPLQRIEAILRAVLRAGAYELERRKDVPAKVVVSEYVDIAHAFVERDETGMVNAVLEQLARQYRADEMGPK
Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.
A5EKH8
O49339
PTI12_ARATH
PTI1-like tyrosine-protein kinase 2
Arabidopsis
MRRWICCGDKKGDSDLSNEEVHLKSPWQNSEANQKNQKPQAVVKPEAQKEALPIEVPPLSVDEVKEKTDNFGSKSLIGEGSYGRVYYATLNDGKAVALKKLDVAPEAETNTEFLNQVSMVSRLKHENLIQLVGYCVDENLRVLAYEFATMGSLHDILHGRKGVQGAQPGPTLDWLTRVKIAVEAARGLEYLHEKVQPPVIHRDIRSSNVLLFEDYQAKVADFNLSNQAPDNAARLHSTRVLGTFGYHAPEYAMTGQLTQKSDVYSFGVVLLELLTGRKPVDHTMPRGQQSLVTWATPRLSEDKVKQCVDPKLKGEYPPKSVAKLAAVAALCVQYESEFRPNMSIVVKALQPLLKPPAPAPAPVPES
Probable tyrosine-protein kinase involved in oxidative burst-mediated signaling leading to specific genes expression.
O49339
Q12289
CRC1_YEAST
Mitochondrial carnitine carrier
Saccharomyces
MSSDTSLSESSLLKEESGSLTKSRPPIKSNPVRENIKSFVAGGVGGVCAVFTGHPFDLIKVRCQNGQANSTVHAITNIIKEAKTQVKGTLFTNSVKGFYKGVIPPLLGVTPIFAVSFWGYDVGKKLVTFNNKQGGSNELTMGQMAAAGFISAIPTTLVTAPTERVKVVLQTSSKGSFIQAAKTIVKEGGIASLFKGSLATLARDGPGSALYFASYEISKNYLNSRQPRQDAGKDEPVNILNVCLAGGIAGMSMWLAVFPIDTIKTKLQASSTRQNMLSATKEIYLQRGGIKGFFPGLGPALLRSFPANAATFLGVEMTHSLFKKYGI
Transports carnitine, acetylcarnitine, propionylcarnitine and to a much lower extent medium- and long-chain acylcarnitines.
Q12289
Q4WE86
AGALB_ASPFU
Melibiase B
Aspergillus subgen. Fumigati
MTTFFSLTTAAAVLTLARGSNALVRPGNVGKLPALGWNTWNAFGCDIDATKIMTAANEVVNLGLKDLGYEYINIDDCWSVKSGRDASTQRIIPDPDKFPDGISGVADQIHDLGLKIGIYSSAGLTTCAGYPASLGYEDIDAQTFAEWGIDYLKYDNCGVPSNWTDTYTYCVPDPGSKATNGTCPDNKNPAPAGYDWRTSLTAERYRRMRDALVSVDRTILYSLCEWGQANVNDWGNETGNSWRTTGDITPSWPRIAAIANENSFLMNHVDFWGYPDPDMLEVGNGNLTLAENRAHFALWAAMKSPLIIGTALDSISQDHLAILSNKILLKFHQDPVIGRPAQPYKWGYNPDWTFDPAHPAEYWSGASSVLGGTLVLMLNSEDTTQRRTAVWKEVPELKDVLGRQGKRRIGFRVTDVWTGKDLGCVRDHYSVELESHDVAALVVGRAC
Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.
Q4WE86
P38883
RIX1_YEAST
Ribosomal export protein 1
Saccharomyces
MSEEFIAVSTLARNLEIAKGNEFHTILATLRSPVYINEQLLKSELSFLVTKILKLIRSGNDFDLWKGCHTSVVTCAYNPLVLSTHGGQLLAAIYSRLEQKTGFYSSVISSSHGKQLFNTLISSVAIIIDLMKNKPTLSREALVPKLKAIIPTLITLSQYEPELVLPVLQRILKRNTTTFKPFTNKFRTVLINLIISDYASLGTKTQRLVCENFAYLHLLKIQVSDTSDDETQAHHKIYADSNWRTGLMSILSQFKPIIQLCGEILDFEQDNELYKLIKSLPVIDESNNKEEFLPSLKLDFNAPLTLWEIPQRLSLLADMLVAFISLPTPFPIRVPLGGINSLCEVLLGVSNKYLPLKKELRHDNELNGVINTILPQIQFQGIRLWEIMVSKYGKCGLSFFEGILSSIELFIPLKKKSNNEIDFNVVGSLKFEFATVFRLVNMILSHLGHQLNIISVISQLIEVALFLSHDKTLIDSLFKNRKSIMKQQTKTKQSKRSKSAEGAFSDIYTHPELFVCKNSMNWFNEINDFFITALNNWILPSTPHIQILKYSITQSLRLKERFGYIPESFVNLLRCEVLHPGSERVSILPIAISLLKNINDDMFELLCHPKVPVGMVYQLHKPLDLGEDGEVRDDINKKEVETNESSSNANTGLETLKALENLENVTIPEPKHEVPKVVDDTAIFKKRSVEEVIERESTSSHKKVKFVEETTVDNGEELIVKKAVSQTKEEEKPMEDSEDEEQEEFEIPAIELSDDEEEEEEEE
Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits . Regulates pre-60S association of the critical remodeling factor MDN1 .
P38883
Q3ZBX9
H2AJ_BOVIN
Histone H2A.J
Bos
MSGRGKQGGKVRAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESQKTKSK
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q3ZBX9
O52594
ACKA_ACET2
Acetokinase
Acetivibrio
MNILVINTGSSSLKYQLIDMTNESVLAKGVCDRIGLEHSFLKHTKTGGETVVIEKDLYNHKLAIQEVISALTDEKIGVIKSMSEISAVGHRIVHGGEKFKESAIIDEDVMKAIRDCVELAPLHNPSNIIGIEACKQILPDVPMVAVFDTAFHQTMPRHAYIYALPYEIYEKYKLRKYGFHGTSHKYVAHRAAQMLGKPIESLKLITCHLGNGASICAVKGGKSVDTSMGFTPLQGLCMGTRSGNVDPAVITYLMEKEKMNINDINNFLNKKSGVLGISGVSSDFRDVQDAAEKGDDRAQLALDIFCYGVRKYIGKYIAVLNGVDAVVFTAGIGENNAYIRREVLKDMDFFGIKIDLDKNEVKGKEADISAPDAKVKTLVIPTNEELEIARETLRLVKNL
Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.
O52594
P13783
FLP_KLULC
Recombinase Flp protein
Kluyveromyces
MSTFAEAAHLTPHQCANEINEILESDTFNINAKEIRNKLASLFSILTMQSLSIRREMKINTYRSYKSAIGKSLSFDKDDKIIKFTVRLRKTESLQKDIESALPSYKVVVSPFKNQEVSLFDRYEETHKYDASMVGLQFTNILSKEKDIWKIVSRIACFFDQSCVTTTKRAEYRLLLLGAVGNCCRYSDLKNLDPRTFEIYNNSFLGPIVRATVTETKSRTERYVNFYPVNGDCDLLISLYDYLRVCSPIEKTVSSNRPTNQTHQFLPESLARTFSRFLTQHVDEPVFKIWNGPKSHFGRHLMATFLSRSEKGKYVSSLGNWAGDREIQSAVARSHYSHGSVTVDDRVFAFISGFYKEAPLGSEIYVLKDPSNKPLSREELLEEEGNSLGSPPLSPPSSPRLVAQSFSAHPSLQLFEQWHGIISDEVLQFIAEYRRKHELRSQRTVVA
Catalyzes the recombination between the large inverted repetitions of the plasmid.
P13783
B1KUY7
PANB_CLOBM
Ketopantoate hydroxymethyltransferase
Clostridium
MRNTVSTFQELKNKGEKITMLTAYDYSMAKLIDSSGINGILVGDSLGMVCLGYENTLSVTMEDMLHHTKAVVRGTSNALVVGDMPFMSYQTSIYDAVYNAGRFIKEAGAHAVKLEGGATVAEEIKAIVKAQIPVMGHIGLTPQSVNMFGGFKVQGKNEKVAKKLIEDAKILEEAGAFAIVLECIPEKLSKIISESISIPTIGIGAGKYCDGQILVYQDMLSMFSDFKPKFVKSFGSIGESIKDGVSQYIKEVKEAKFPEEKHAFKIDDDVINKLY
Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.
B1KUY7
Q3B8N7
T22D4_RAT
Thg-1pit
Rattus
MSGGKKKSSFQITSVTTDYEGPGSPGASDPPAPPAPAGPPPRLPNGEPNPDPGGRGTPRNGSPPPGAPASRFRVVKLPQGLGEPYRRGRWTCVDVYERDLEPPSFGRLLEGIRGASGGTGGRSLDSRLELASLGISTPIPQPGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLAGPGKAKVETPPLSASPPQQRPPGPGTGDSAQTLPSLRVEVESGGLAAGTPPLSRRRDGAVRLRMELVAPEETGKVPPIDSRPNSPALYFDASLVHKSPDPFGAAAAQSLSLARSMLAISGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRDLAERNAALEQENGLLRALASPEQLAQLPSSGLPRLGPSAPNGPSI
Transcriptional repressor.
Q3B8N7
Q8D304
PDXJ_WIGBR
Pyridoxine 5'-phosphate synthase
Wigglesworthia
MSKLLLGVNVDHVASLRNVRGGKFPDPVQLAILAEIAGADSITTHLREDNRHINEKDVICIKKSIQSRLNLEISTKKEMINKAINILPYSCCLVPENRQEITTESGIDVIKNKKYLKKVICKLKSLGIKVSLFVDPIKNQILSSSEINADCIEINTGKYSEQDKKENKEEINLIKLCAKYANKLGLEVHAGHGLNYFNVRSIVNIKEIKELNIGHSIISRSLIVGMQNAVKEMKDIIYSEKIKWQ
Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.
Q8D304
Q94JJ7
H2B3_ORYSJ
Histone H2B.3
Oryza sativa
MAPKAEKKPAAKKPAEEEPAAEKAEKAPAGKKPKAEKRLPAGKAEKGSGEGRKAGRKKAKKSVETYKIYIFKVLKQVHPDIGISSKAMSIMNSFINDIFEKLAGESAKLARYNKKPTITSREIQTSVRLVLPGELAKHAVSEGTKAVTKFTSA
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Q94JJ7
Q3AFE0
Y272_CARHZ
Nucleotide-binding protein CHY_0272
Carboxydothermus
MRFLIVTGLSGAGKTQAMRALEDLGYFCVDNLPPVLMPKFAELVAHAENKIEKVALVVDVRGQKFFQDLDWALGELTKLGIKYEILFLEARDEVLLKRFKANRRGHPLGVRGSQILDNIKKERKFLENLRARADKVIDTSDLQPADLRNEILNYYGEEQKRSKISINIVTFGYKYGLPLDADLIMDVRFLPNPFYVKELRPLSGSDKPVYDYVFNYEVTKKFTEKFLDLIEFLMPFYQKEGKSNLVIAIGCTGGRHRSVAIANFLARTLEEKNYEVYLRHRDLEKHREE
Displays ATPase and GTPase activities.
Q3AFE0
Q0SHT6
LSPA_RHOJR
Signal peptidase II
Rhodococcus
MDDERVSQDPTAENETDAEDRNDDDPSGSAPPQPVTHQRRLLLFVIAGVVLATDLLTKILAVANIEPGRPVWLIGDIVSLRLVRNPGAAFSMATGMTWLLTLVAVGVVIGVVRIGRTLRSPWWALGLGLVLGGALGNLVDRFFRAPGVMQGHVVDFVSVGWWPVFNVADSGIVCGAILLVVLTLIGLEPDGTRKGVEK
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
Q0SHT6
F8J2E1
3L273_DRYCN
Long neurotoxin 73
Drysdalia
MKTLLLTLVVVTIVCLDLGDSLICYQAYNTPQTCAPGENLCYTKTWCDYWCHVKGKRIDLGCAATCPTAKPGEDVTCCSRDKCNPHPLQRPR
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission.
F8J2E1
Q9SBQ7
METK3_PETHY
Methionine adenosyltransferase 3
Petunia
METFLFTSESVNEGHPDKLCDQISDAVLDACLEQDPESKVACETCTKTNLVMVFGEITTKANVDYEKIVRDTCRNIGFISDDVGLDADNCKVLVYIEQQSPDIAQGVHGHLTKQPEEIGAGDQGHMFGYATDETPEFMPLSHVLATKLGARLTEVRKNGTCPWLRPDGKTQVTVEYYNENGAMVPVRVHTVLISTQHDETVTNDEIAHDLKEHVIKPVIPEKYLDEKTIFHLNPSGRFVIGGPHGDAGLTGRKIIIDTYGGWGAHGGGAFSGKDPTKVDRSGAYIVRQAAKSVVANGLARRCIVQVSYAIGVPEPLSVFVDTYGTGMIPDKEILKIVKENFDFRPGMIAINLDLKRGGNGRFLKTAAYGHFGRDDTDFTWEVVKPLKCEKAQD
Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
Q9SBQ7
O46521
CY24A_BOVIN
p22-phox
Bos
MGQIEWAMWANEQALASGLILITGGIVATAGQFTQWYLGAYSIAAGVLVCLLEYPRGKRSKGSTMERCGQKYLTRVVKLFGPLTRNYYIRAFLHLGLAVPAGFLLATILGTACLAIASGIYLLAAIRGEQWSPIEPKPKERPQIGGTIKQPPSNPPPRPPAEARKKPSEEAAGVPTGGPQENPMPVNDEVV
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
O46521
P25490
TYY1_HUMAN
Yin and yang 1
Homo
MASGDTLYIATDGSEMPAEIVELHEIEVETIPVETIETTVVGEEEEEDDDDEDGGGGDHGGGGGHGHAGHHHHHHHHHHHPPMIALQPLVTDDPTQVHHHQEVILVQTREEVVGGDDSDGLRAEDGFEDQILIPVPAPAGGDDDYIEQTLVTVAAAGKSGGGGSSSSGGGRVKKGGGKKSGKKSYLSGGAGAAGGGGADPGNKKWEQKQVQIKTLEGEFSVTMWSSDEKKDIDHETVVEEQIIGENSPPDYSEYMTGKKLPPGGIPGIDLSDPKQLAEFARMKPRKIKEDDAPRTIACPHKGCTKMFRDNSAMRKHLHTHGPRVHVCAECGKAFVESSKLKRHQLVHTGEKPFQCTFEGCGKRFSLDFNLRTHVRIHTGDRPYVCPFDGCNKKFAQSTNLKSHILTHAKAKNNQ
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; proposed to target the INO80 complex to YY1-responsive elements.
P25490
Q41011
EF1A_PEA
Elongation factor 1-alpha
Pisum
MGKEKVHINIVVIGHVDSGKSTTTVHVIYKLGGIDKRVIERFEKEADEMNKRSFKYAWLLDKLKAERERGITIDIALLKFETTKYYSTVMDAPGHRDFIKNMITGTSQADCAVLIIDSTTGGFEAGISKDGQTREHALLAFTLGVKQMICCCNKMDATTPKYSKGRYEEIVKEVSSYLKEVGYNPDKIPFVPISGFEGDNMIERSTNLDWYKGPTLLDALDNINEPKRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGVVKPGMLVTFAPTGLTTEVKSVEMHHEALTEALPGDNVRFNVKNVAVKDLKHGLVASNSKDDPAKDAANFTSQVIIMNHPGQIGNGYAPVLDCHTSHIAVKFAELITKIDRRSGKEIEKEPKFLKNGDAGMVKMIPTKPMVVETFAEYPPLGRFAVRDMRQTVAVGVIKSVEKKDPTGAKVTKAAAKKK
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Q41011
A8FYR3
RF3_SHESH
Peptide chain release factor 3
Shewanella
MSGNKVEVDKRRTFAIISHPDAGKTTITEKVLLFGNALQKAGTVKGKKSGQHAKSDWMEMEKDRGISITTSVMQFPYNGALVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDSAKGVEQRTIKLMEVTRLRDTPIVTFMNKLDRDIRDPLELMDEVEKVLNIACAPITWPIGCGKEFKGVYHLLRDEVILYQSGQGHTIQDSTIIKGLDNPELDAAIGTYAAEVREELELVLGASNEFDLELFLAGELTPVYFGTALGNFGVDHILDGIVEWAPKPQARETEVREVQPEDEKFSGFVFKIQANMDPKHRDRVAFMRVCSGRYEQGMKMHHVRLGKDVNVSDALTFMAGDRNRAEVAYPGDIIGLHNHGTMRIGDTFTQGEKLRFTGIPNFAPEMFRRIRLKDPLKQKQLLKGLVQLSEEGAVQVFRPIDTNDLIVGAVGILQFEVVVGRLKSEYKVEAIYEAISVSTARWVYCDDERKLEEFRRKCSTNLALDGGDNLTYIAPTMVNLNLSMERYPDIKFAKTREN
Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.
A8FYR3
B4PST7
SOTI_DROYA
Male-specific protein scotti
Sophophora
MDTLLEHEAADLYDEQQIDRIGDAVTGDAGDDSDDTLEDGQQLLGVNRQMDILLDAPQEPPMAVFPARGGPNGGPPRLRKKRSFYTMVKPTPPCQSREPEMCRLMASVTRAMRQVREDQRGEYFANYLVENMTSQNYPNGVGLPQHWGQF
Post-meiotically transcribed gene that has a role in late spermiogenesis; required for actin cone progression during spermatid individualization.
B4PST7
Q2K6Q4
ZNUC_RHIEC
Zinc import ATP-binding protein ZnuC
Rhizobium
MLSPANAKNQRLVSLEDVGVLRGGRWLVRGVEFSVSRGEIVTLIGPNGSGKSTSAKAAIGVLKPDEGRVERLSGLKVGYVPQKLSIDWTLPLTVRRLMTLTGPLPERDMQAALEAAGIAHMIGAEVQHLSGGEFQRALMARAIARKPDLLVLDEPVQGVDFSGEIALYHLIKSIRNASGCGILLISHDLHVVMAETDTVICLNGHVCCRGTPEAVSRSPEYVRLFGSRAAQTLAVYSHHHDHTHLPDGRVLHADGSVTDHCHPEDGHHAHDSQEHAHGQDHVHAHEHSHDDHHGHDHAHEHAHSRSGEGRHA
Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system.
Q2K6Q4
Q9SWG0
IVD_ARATH
Isovaleryl-CoA dehydrogenase, mitochondrial
Arabidopsis
MQRFFSARSILGYAVKTRRRSFSSRSSSLLFDDTQLQFKESVSKFAQDNIAPHAERIDKTNSFPKDVNLWKLMGEFNLHGITAPEEYGGLGLGYLYHCIAMEEISRASGSVALSYGAHSNLCINQLVRNGTAAQKEKYLPKLISGEHVGALAMSEPNAGSDVVGMKCKAEKVDGGYILNGNKMWCTNGPSAETLVVYAKTDTKAGSKGITAFIIEKGMTGFSTAQKLDKLGMRGSDTCELVFENCFVPEENILDKEGKGVYVLMSGLDLERLVLAAGPLGIMQACLDNVLPYIRQREQFGRPVGEFQFIQGKVADMYTALQSSRSYVYSVARDCDNGKVDPKDCAGTILCAAERATQVALQAIQCLGGNGYINEYATGRLLRDAKLYEIGAGTSEIRRIVIGRELFKEE
Involved in degradation of the branched-chain amino acids, phytol and lysine for the supply of carbon and electrons to the ETF/ETFQO complex during dark-induced sugar starvation.
Q9SWG0
C5BQA1
FABA_TERTT
Trans-2-decenoyl-[acyl-carrier-protein] isomerase
Teredinibacter
MQDFVPNSSYTREELIACGNGELFGPGNAQLPVPNMLMLDRIAHISTTGGEYGKGEIIAELDIHKDLWFFGCHFPGDPVMPGCLGLDAMWQLVGFFLAWKGNPGRGRALGSGEVKFTGQILPTAKQVTYHIHLKRVIERKLIMGIADGRVAVDGKEIYFAKDLRVGLFSNTDTF
Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length.
C5BQA1
Q8LWM2
CYB_URILO
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Uria
MAPNLRKSHPLLKLINNSLIDLPTPSNISAWWNFGSLLGICLLTQILTGLLLATHYTADTTLAFSSVAHTCRNVQYGWLIRNLHANGASFFFICIYLHIGRGFYYGSYLNKETWNTGVILLLALMATAFVGYVLPWGQMSFWGATVITNLFSAIPYIGQTLVEWAWGGFSVDNPTLTRFFALHFLLPFMIAGLAFIHLTFLHESGSNNPLGILSNCDKIPFHPYFSLKDILGFIIMFLPLTTLALFSPNLLGDPENFTPANPLVTPPHIKPEWYFLFAYAILRSIPNKLGGVLALAASVLVLFLTPLLHKSKQRAMTFRPLSQLLFWTLVANLLILTWVGSQPVEHPFIIIGQLASLAYFTILLLLFPIVGALENKMLNY
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q8LWM2
P48089
IL1A_MACMU
Hematopoietin-1
Macaca
MAKVPDMFEDLKNCYSENEEDSSSIDHLSLNQKSFYDVSYGPLHEGCMDQSVSLSISEISKTSKLTFKQSMVVVSTNGKVLKKRRLSLSQSITDNNLEAIANDSEEEIIKPRSAPFSFLSNMTYHFIRIIKHEFILNDTLNQTIIRANDQHLTAAAIHNLDEAVKFDMGAYTSSKDDTKVPVILRISKTQLYVSAQDEDQPVLLKEMPEINKTITGSETNFLFFWETHGTKNYFISVAHPNLFIATKHDNWVCLAKGLPSITDFQILENQA
Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. In addition to its role as a danger signal, which occurs when the cytokine is passively released by cell necrosis, directly senses DNA damage and acts as signal for genotoxic stress without loss of cell integrity.
P48089
Q6LGK4
GUAC_PHOPR
Guanosine 5'-monophosphate oxidoreductase
Photobacterium
MRIEQDLKLGFKDVLFRPKRSTLKSRSQVELTRDFTFKHSGRQWSGVPIIAANMDSVGSFEMAASLSKHNVMTAIHKHYTVDDWAGFVKNNDAAVLNNAMVSTGTSEADFQKTKDIMALTEDLIFICIDIANGYSEHLVEYVQKVRAEFPTKVISAGNVVTGDMVEELILAGADIVKVGIGPGSVCTTRVKTGVGYPQLSAIIECSDAAHGLGGRIIGDGGCSCAGDVSKAFGGGADFVMLGGMLAGHEESNGEVIEKDGEMFMKFYGMSSQSAMDKHSGGVANYRAAEGKTVLLPFRGPVENTIQDIMGGIRSTCTYVGAAQLKELTKRATFIRVQEQENNVYGKE
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Q6LGK4
A7FD14
BTUB_YERP3
Outer membrane cobalamin translocator
Yersinia
MTIKKYTLLTALSVTAFSGWAQGNNTTDNNNEMVVTANRFPQPKSSVLAPVDVVTRADIDRWQSTNINDVLRRLPGINIAQYGGPRQLSSLFIRGTNSSHVLVLVDGVRLNQAGISGSSDLSQIPISLVQRIEYIRGPRSAVYGSDAIGGVVNIITERETLGSTLTAGLGSNGYQNYNGSTQQKLGDDTTITLAGNYDYSKGYDVVAKGNTGMASQPDRDGYLGKMLWLGANHKFNEQFSGFVRGYGFDNRSDYDSYYYPGSPLVDTRSLSSRTYDTGINFSNGGYASQLIGSYSRTQDYNYDPSYGRYDQSATLDDISQYNLQWTNTYQLGLGNVGGGLDWQKQTTEPGTNYLSNGYEQRNTGVYGTVQQFVGPVTLEGAIRGDDNSQFGWHTTWQSSAGWEFVDGYRLIGSYGTAFKAPNLGQIYSSTYGNRDLKPEESTQWEAAITGITGPLDWRLSAYRNDIDQMIATRGVYPNSRYYNVEKATIKGVEWTGSFETGPLSHQVTLEYLDPRNADTHEILARRAKQQVKYQLDWQMADLDWSVTYQYIGQRYDSVFDPITYAASPVKLAGISLWDLAVSYPVTSHLTVRGRIANLFDKDYEMVYGYQTPGREYYFTGSYNF
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
A7FD14
C1CV60
SUCC_DEIDV
Succinyl-CoA synthetase subunit beta
Deinococcus
MKLHEYQGKEILRQFGVNVQDGKVARTPDEVRQIAREYGQPVVVKAQVHVGGRGKAGGVKFSPTEDKAFENGEKILGMDIKGLTVNKVLVTKAVDIDAGTEYYVGMIVDRNVQSFTLMASAEGGMEIEEVAAATPEKIIKHRVDPVTGLRPYEAREVAIRAGFKGNLNKIADMMVKMSEAALKRDAVLVEINPLFVGPDGVPLALDTKFEIDDNAMYRHQDLADWRELEAEHPLEIEASKYGFAYVKLDGNVGVLGNGAGIVMTSLDVVNRAGAKPANFLDIGGGAKAEVVYNAVKLVSKDSDVKAIFINIFGGITRADEVAKGVIQALKDGILTKPVRMRIAGTAEDEAKALLAEVNSPLIQMYPTMFEAADEAAKEANAAEAK
Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
C1CV60
Q9Z255
UBE2A_MOUSE
Ubiquitin-protein ligase A
Mus
MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFTEEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWRDC
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
Q9Z255
P95619
CRTC_RUBGE
Neurosporene hydratase
Rubrivivax
MRAAESGADARVRPVDRVEPADAPAGDAGGLRAAVPGDGGSAVRPGDARLDVLVPPGLVDEPAAGALPGGGQRAPGAGRADGGDVRPVGGRDADGAPRFDQPVPPGGYLWWYVDAVSDDGRHGLTFIAFVGSVFSPYYAWAGGPKADRADPENHCALNIALYGDAGKRWTMTERGRRWMRRSRDEFVIGPSRLHWDGESLLVEFDEVGVPIPRRVKGRVRVWPKALCRFVTSLDSGGRHRWGPIAPCSRIEVELDSPRVRWSGHAYLDSNEGDEPIDRPFREWDWSRATMADSSTAVIYDVRQKRDGDRVIAERFLLDGSTESFEAPPRQPLPTTLWRIGRTMRTEPGVPALVEQTLEDTPFYARSMVRSGLLGEVVTSVHETMLLPRVITLPVRLMLPWRMPRRA
Involved in the biosynthesis of carotenoids spheroidene and spirilloxanthin. Catalyzes the hydration of neurosporene to the corresponding hydroxylated carotenoids 1-HO-neurosporene and 1,1'-(HO)2-neurosporene and that of lycopene to 1-HO-lycopene and 1,1'-(HO)2-lycopene. Can also act on demethylspheroidene, spheroidene, 1-HO-3,4-didehydrolycopene and geranylgeraniol.
P95619
Q02T64
RL18_PSEAB
50S ribosomal protein L18
Pseudomonas
MSVKKETRLRRARKARLKMRELETVRLCVYRSSQHIYAQVIAADGGKVLASASTLDKDLREGATGNIDAAKKVGQLVAERAKAAGVTQVAFDRSGFKYHGRVKALADAAREGGLEF
This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
Q02T64
Q9PC50
RSMG_XYLFA
16S rRNA 7-methylguanosine methyltransferase
Xylella
MNDSSLSPEVTADLEYGLDILELDRVYVVPLLAYLTLLIRWNRTYNLTAIRDPREMVVRHLLDSLAIQRYVTVGRLADLGSGPGLPGIPLAISCPSLQVTLVESNGKKARFLREVVRQLGLSNVGVSEVRAEALDEALTYEHLTARALDTLNGIVTVGGHLLKSEGTLLAMKGAYPHEEIAMLPPHWVVEAVHPLQVPKLTGKRHLVIVRKR
Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.
Q9PC50
Q85PP8
NU2M_GENSE
NADH dehydrogenase subunit 2
Genetta
MKPPIFFLIMSTVISGTLIVMTSSHWMLTWIGFEMNMLAIIPILMKKFNPRSMEASTKYFLTQATASMLLMMGIIINLLYSGQWTVPNNPNPMASILMTTALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKIAPLSVLYQISPTINPNLLLPMATLSVLIGGWGGLNQTQLRKILAYSSIAHMGWMTAILLYNPTMMILNLTIYIIMTLTTFMLFMLNSTTTTLSLSQTWNKMPLITSLITMLMLSLGGLPPLSGFMPKWMIIQELTKNEMIIMPTFLAITALLNLYFYMRLTYATALTMFPSTNNMKMKWQFESTKKMTFLPPLIITSTMLLPLTPMISILD
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Q85PP8