accession stringlengths 6 10 | name stringlengths 6 11 | Full Name stringlengths 1 147 ⌀ | taxon stringlengths 3 46 ⌀ | sequence stringlengths 16 2.75k | function stringlengths 6 5.51k | AlphaFoldDB stringlengths 6 10 |
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C9K2Q3 | BSC8_ALTBR | Geranylgeranyl diphosphate synthase | Alternaria sect. Brassicicola | MKYQFSIIVDPATYDNEGLSNGIDLRKNNFTHLEDRGAIRAQQDWATHIAPIKQFKGTLGHDYSFMTVCVPECIPIRLEIISYANEFAFMYDDDTELDTENNTSAENDKLMGTFLAGTQGWSPPQDQSSSGKTRILKQLFSEMMEIDKECAIATMKAWAEFLRVGSSRQHGTVFTRLKDYLPYRIKDVGEMFWFGVVTFGMALHIPDHEMDACHKLMEPAWIAVGLANDVFSWPKERDASQRLGRTHVVNAVWVVMQEHGFSQEQARQYCRELAAQFVAQYLDNIRNIKNEESISPDLRTYVEAMQYSISGNVIWSKFCP... | Multifunctional diterpene synthase; part of the gene cluster that mediates the biosynthesis of the diterpene glucoside brassicicene C . In the first step of the brassicicene C biosynthesis, the bifunctionnal diterpene synthase bsc8 that possesses both prenyl transferase and terpene cyclase activity, converts isopenteny... | C9K2Q3 |
Q3Z976 | RL22_DEHM1 | 50S ribosomal protein L22 | Dehalococcoides | MEVKAIVKDTGYSALKVRLCVDMVRGKKVSEAITMLRFMTSPTAKVVSKVIKSAAANAENNFQMNPADLKISQIYADEARMLKRMRPQARGRVSPILKRSSHITVVVAD | The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. | Q3Z976 |
P20944 | CD44_CRIGR | Phagocytic glycoprotein I | Cricetulus | MDKFWWHAAWGLCLLPLSLAHEQIDLNITCRYAGVFHVEKNGRYSISRTEAADLCQAFNSTLPTMDQMVMALSKGFETCRYGFIEGHVVIPRIQPNAICAANHTGVYILTSNTSHYDTYCFNASAPLEEDCTSVTDLPNSFEGPVTITIVNRDGTRYSKKGEYRTHQEDIDASNTTDDDVSSGSSSEKSTSGGYVFHTYLPTIHSTADQDDPYFIGSTMATRDQDSSMDPRGNSLTVTDGSKLTEHSSGNQDSGLNSTSRPGGKPRVPEWLIVLASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGKVEDRKPSELN... | Cell-surface receptor that plays a role in cell-cell interactions, as well as cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hemato... | P20944 |
P49188 | CRF_XENLA | Corticotropin-releasing hormone | Xenopus | MKFQLWVSTGILLVSLLPCHECRAFIKSPASSPGALLPALSNSQPFLLRMGEEYFLRLGNLHKHSPGSFPEASAGNFVRAVQQLQAQQWSSQPGMRAASLDGADSPYSAQEDPTEKAKRAEEPPISLDLTFHLLREVLEMARAEQIAQQAHSNRKLMDIIGK | This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. | P49188 |
Q5LPK1 | GATB_RUEPO | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B | Ruegeria | MLDLTFETPKPKTIAGAKHDWELVIGMEVHAQVASQAKLFSGASTAFGAEPNSNVSFVDAAMPGMLPVINEFCVEQAVRTGLGLKAEINLKSAFDRKNYFYPDLPQGYQISQLYHPIVGEGEVLVEMGDGTARRVRIERIHMEQDAGKSIHDMDPNMSFVDLNRTGVCLMEIVSRPDIRGPEEAAAYIAKLRQILRYLGTCDGNMQNGNLRADVNVSICRPGAYEKYQETQDFSHLGTRCEIKNMNSMRFIQAAIEYEARRQIAIVEAGGEVDQETRLYDPDKNETRSMRSKEEAHDYRYFPDPDLLPLEIEQAWVDDIA... | Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated ... | Q5LPK1 |
Q46L69 | RS15_PROMT | 30S ribosomal protein S15 | Prochlorococcus | MSLGTEEKQNLINTHQVHPTDTGSAEVQVAMLTTRISKLSTHLQGNIHDFSSRQGLLKMIGQRKRLLGYVRSKSEKRYTELIEKLAIRG | Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. | Q46L69 |
P11987 | MEMG_METCA | Methane hydroxylase | Methylococcus | MAKLGIHSNDTRDAWVNKIAQLNTLEKAAEMLKQFRMDHTTPFRNSYELDNDYLWIEAKLEEKVAVLKARAFNEVDFRHKTAFGEDAKSVLDGTVAKMNAAKDKWEAEKIHIGFRQAYKPPIMPVNYFLDGERQLGTRLMELRNLNYYDTPLEELRKQRGVRVVHLQSPH | Responsible for the initial oxygenation of methane to methanol in methanotrophs. It also catalyzes the monohydroxylation of a variety of unactivated alkenes, alicyclic, aromatic and heterocyclic compounds. | P11987 |
A8F801 | PURA_PSELT | null | Pseudothermotoga | MLKAAVIGLQWGDEGKGKVVTYLSRRYDCVVRYSGGSNAGHTVDYGNFKMVHHLLPSADIKKQKMMYIGPGVVVDLDVLLEEIDQINNLIPESRSLLRISKQAHVVIPIYRDLDEKIDSSRANQIGTTRRGIGISYANRAMRCGLRLEDFETPARAESFLNEISRTWSIKFDVKMILDSLIEKYNKIRDLLIDSSEAVRVLKEKDLLFEGTQGVLLDVDMGTYPYVTSTNCSTTGIQPGFGYPVQVDKIFGVMKAYTTRVGEGPFPTELKDEVGENLRRLGSEYGATTRRPRRCGWLDLVLIKYAIETSACNALIMTKAD... | Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. | A8F801 |
Q8EPQ8 | QUEA_OCEIH | Queuosine biosynthesis protein QueA | Oceanobacillus | MQIEDFDFHLPEELIAQTPLKDRTSSRLCVLDKQTSEITHRSFKDITTYLQAGDCLVLNDTKVLPARLYGVKSDTGAKIEVLLLHQQEEDTWEVLVKPAKKVKVGTEIIFGNGKLKATCIDLKDHGGRIMTFSYTGIFYEILDQLGEMPLPPYIKEQLPEQDRYQTVYAKEKGSAAAPTAGLHFTDKLLEDIKAMGVNIVFVTLHVGLGTFRPVSVDSVEDHDMHSEFYSMSESAAKTLNEAKAAGRRIISVGTTSTRTLETIVRDHDGKFVATRGWTDIFIYPPYKFRAIDGLITNFHLPKSTLIMMISALAGKEAILH... | Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | Q8EPQ8 |
Q557H3 | VP35L_DICDI | VPS35 endosomal protein sorting factor-like | Dictyostelium | MAERQSASSPTPSSPPQQQQQTPQQPPQYLLNSKKNFKVKVLNGREVERHPLNSITKTEDTGKPKQSSLSSNASSLQSAAAAASSSTATTDIDPLNNNNNNNTDIDPLNNPLEKKHDPLSETIATMGGLKLIKENHLTNYVDENFMPWDTLKPSILQQYTSDDSNPIQVSFMSTGTSGKIKIPINRLNKILEELEQDKEDSKSTQFSQPDIIMDLETLHSELLKAWAAEERVRSLKIAIQTAKLLSDTSLIKFYPSKFVIATEILDTFGNLVYDRIKKRLQSSKESKNHEILLKEQAKETCRNWFYKIASIRELLPRLFV... | Acts as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos. | Q557H3 |
A4YCW6 | RL3_METS5 | 50S ribosomal protein L3 | Metallosphaera | MGHRKLSSPRRGSAGLRPRKRSEELLPSPRSYPEVNLPNPVTLGFVGYKVGMTHIFMIDEDRSSSMFGKEIYVPVTVLETPPIYVLALRAYGLNNRGEHSVMGEVWGDLGDFGKFITRRIRGLKIDKEKKEHQLKDIESNLESVSYFRLLVSTQPHLIPALGKKTPDIVEVQIGGGNTKNQLEYGLKLLGNTLSVRDVFKEGQLMDIIGVTKGHGFQGVIKRYGVQELPRWHKHRKGSRKVGTKGPSLGTPSYVPQPGQMGFHRRTEYNKRILKISDDTKLINPKGGFVRYGLVKNTYLLVQGSTIGSIKRPLFLRYPIR... | One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. | A4YCW6 |
Q3SH78 | GLGB_THIDA | Glycogen branching enzyme | Thiobacillus | MRKLVEATQAGSEASVALAPSAPIQRLQAGLHHDPFEVLGVHVQPDGSKLVRAFLPAAEAVEVAGVRMTRVPGTDCFERLLPPGTALEAHPLLTWQDKRSGAWQRLRSPYSFAPQLGEMDLYLFGEGRHFEIWKVLGARVKTVDGVTGCLFAVWAPAVLRVSVVGDFNDWDGRRHPMRCRGVSGVWELFIPGLEAGHAYKYEILGRHGERVTKTDPYARQMFLRPETTSRVPDERPYAWGDAEWLAARTRFDWQHRPMSVYEVHPGSWRRRADGSFYSWRELTAELIPYVRDLGYTHIELLPVAEHPFDASWGYQVSGYY... | Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position. | Q3SH78 |
Q03ZG8 | RECR_LEUMM | Recombination protein RecR | Leuconostoc | MQYPEPIAKLIDSYTKLPGIGPKTATRLAFYTLGMNEEDVQDFSKALISAKTDLTFCSICGNITATDTDPCVICRDQSRDQSTVFVVENSRDVMAMENTRDYHGLYHVLNGVISPSAGTGPEDINLPSLIRRLSEHEEIKEVIVGTNANAEGEATAMYLARLLKPAGIAVTRLAHGLAVGSDIDYADELTLIKAVQGRTKL | May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | Q03ZG8 |
Q9BXA5 | SUCR1_HUMAN | P2Y purinoceptor 1-like | Homo | MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSF... | Receptor for succinate. | Q9BXA5 |
B3EP06 | MDH_CHLPB | Malate dehydrogenase | Chlorobium | MKITVIGAGHVGATAAHRIAEQQLANTVVLFDILEGIPQGKALDMYESGPVGLFDTKVYGTTDYNDTADSDIILITAGMARKPGMSREDLLMKNATIVKEVTDQVVRFSKNPIIIMVSNPLDIMTHVGYIRSKLPKERVLGMAGVLDSARFRSFIAEELNVSMRDINAFVLGGHGDSMVPVVKYTSVAGIPLTELMAQDTIEQLVDRTRKGGAEIVNYLKNGSAYYAPASSAVEMIDAIVNDRKRILPCSALLEGQYGINNVYIGAPVKLGKNGIEQILEIDLDAPELDALRKSAAIVEENCNNLASLLA | Catalyzes the reversible oxidation of malate to oxaloacetate. | B3EP06 |
A9BPU6 | ATPG_DELAS | F-ATPase gamma subunit | Delftia | MAAGKEIRGKIKSVENTKKITKAMEMVAASKMRKAQERMLAARPYSEKIRNIAVHLGQANPEYVHPFMQVNGDAKTAGVIVVTTDKGLCGGMNTNVLRAVTAKLRELQDQGVSAEAVAIGNKGLGFLNRVGAKVVSHATGLGDTPHLEKLIGPVKVLLDAYAAGKLSAVYLSYTKFINTMKQESVVEQLLPLSSESMQAEKTSGHSWDYIYEPDAQSVIDELLVRYAESLVYQAVAENMASEQSARMVAMKAATDNAGNVISELKLVYNKTRQAAITTELSEIVAGAAAV | Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. | A9BPU6 |
Q1MIC8 | RS14_RHIL3 | 30S ribosomal protein S14 | Rhizobium | MAKTSAVEKNKRRRTTVANQAAKRAGLKAIIMNQALPIEERFKASIKLASLPRDGSKTRIRNRCEVSGRPRAYYRKLRMSRIALRELGNLGKVPGIVKSSW | Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. | Q1MIC8 |
A4SD60 | MEND_CHLPM | Menaquinone biosynthesis protein MenD | Chlorobium | MNNPQLTTVWSSVMVEELIRQGASFFCISPGSRSTPLTAAIARNPEASWKMFPDERSAGFFALGHARATGFPAVLVCTSGTAVANYLPAVVEASNDRIPMLILSADRPFELRECGANQTIRQNGIFGTFTRWQMELPEPSTSIPLQSLLSTIAHGVEKSLNSPRGPVHLNQPFREPFEPESCSTPEPWLEPLQAWQTGRRPSTVAAQPEKHPDMDSMRTLRELTGNARQPLIIAGNSTDENDSHAIAELADDLQVPLYADMTSGLRFSSSILPWQQAFASPEFRNAFRPDLVIHFGGGLISRHPSDALKQWKPDHLAVIR... | Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | A4SD60 |
O75385 | ULK1_HUMAN | Unc-51-like kinase 1 | Homo | MEPGRGGTETVGKFEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAKSQTLLGKEIKILKELKHENIVALYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQNILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSIGTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIPRETSAPLRQLLLALLQRNHKDRMDFDEFFHHPFLDASPSVRKSPPVPVPSYPSSGSGSSSSSSSTSHLASPPSLGE... | Serine/threonine-protein kinase involved in autophagy in response to starvation . Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes . Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulat... | O75385 |
Q9F2F9 | ELMGT_STROV | Elloramycin glycosyltransferase ElmGT | Streptomyces | MRVLAVATPALGHLFPAVPLLWALRARGDEVLVVTGGDALRVAEAGLPVVDALPGETLTTLFGAYQETDPAFFVALRRSPMTTLRDLAPVLAYLAGRLLEPARRAAERWRPDAILATHGQAAGAVVAAEHGIPLVEHGFGFVRSDGAQEAVRQLLAERLGPAGSEPPPERYFLDIAVPSMTSAIEGMSLRAVPYNGGAVLPLSGASVGGRPPRPRVLVTAGTQLLHTHGAGALAWLPEVAAGHEAEFLLAAGGADLRDLGRLPPHVRVLDWTPLATVLPTCSAVVHHGGSGTTLAALAAGVPQLVSPALADNHINARAVA... | Glycosyltransferase that transfers an L-rhamnose moiety from dTDP-L-rhamnose to the elloramycin aglycone 8-demethyl-tetracenomycin C (8DMTC) in elloramycin biosynthesis, an antitumor polyketide. Possesses donor substrate flexibility: able to transfer at least 11 different sugars to 8DMTC, such as NDP-D-glucose, as well... | Q9F2F9 |
G1UH28 | CHIT_PUNGR | Pomegranate seed chitinase | Punica | MAKTLPFSRALLLSLSILLVARAISAGDIAIYWGQNGGEGTLASTCDTGRYAYVIVSFVTTFGNFRAPVVNLAGHCDPAAGTCTGLSDEIRSCQGKDIKVLMSIGGGAGDYSLVSEADADNFADYLWNNFLGGQSSSRPLGDAVLDGIDFDIELGTTTFYDTLARALSSRSTQAAKVYLTAAPQCPHPDSHLDAALNTGLFDNVWIQFYNNPLAQCQYSSGNTNDILSSWNTWTSSTTAGKIFLGLPAAPEAAGSGYIPPDVLTGQILPQIKTSAKYGGVMLYSKFYDTTYSTTIKDQV | Hydrolyzes chitin. Probable calcium storage protein of the seeds. Binds calcium ions with high capacity and low affinity. Involved in seed germination. | G1UH28 |
G5EGK8 | PP2A_CAEEL | Serine/threonine-protein phosphatase 2A catalytic subunit | Caenorhabditis | MAAAPPSADPLDKALIVDVDQWIEQLYECKPLSENQVKTLCEKAKEILEKEPNVQEVRCPVTVCGDVHGQFHDLMELFKMGGKSPDTNYLFMGDYVDRGYYSVETVSLLVCLKIRYKDRVTLLRGNHESRQITQVYGFYDECLRKYGNSNVWKYFTDLFDCFPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWSHDRNVVTVFSAPNYCYRCGNQAAMVELDDDLKYSFLQFDPAPRRGEPHVTRRTPDYFL | Protein phosphatase which plays an essential role in early embryonic cell division . Probably together with constant regulatory subunit paa-1 and regulatory subunit sur-6, positively regulates centriole duplication by preventing the degradation of sas-5 and kinase zyg-1 . In addition, plays a role in the recruitment of... | G5EGK8 |
O04609 | WRK22_ARATH | WRKY DNA-binding protein 22 | Arabidopsis | MADDWDLHAVVRGCSAVSSSATTTVYSPGVSSHTNPIFTVGRQSNAVSFGEIRDLYTPFTQESVVSSFSCINYPEEPRKPQNQKRPLSLSASSGSVTSKPSGSNTSRSKRRKIQHKKVCHVAAEALNSDVWAWRKYGQKPIKGSPYPRGYYRCSTSKGCLARKQVERNRSDPKMFIVTYTAEHNHPAPTHRNSLAGSTRQKPSDQQTSKSPTTTIATYSSSPVTSADEFVLPVEDHLAVGDLDGEEDLLSLSDTVVSDDFFDGLEEFAAGDSFSGNSAPASFDLSWVVNSAATTTGGI | Transcription factor involved in the expression of defense genes in innate immune response of plants. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Activates WRKY 29, SIRK and its own promoters. | O04609 |
A9II17 | NUOH_BORPD | NDH-1 subunit H | Bordetella | MEWLDILESHGQALLGPTAWLVLWTIVKIVVIAVPIILCVAYLTYWERKMIGWMHVRLGPTRVGFRGLLQPFADVFKLLTKEVVVPTQANKILFVVAPVVTLMPALAAWAVVPFGPEVVLANVNAGLLYVMAITSIGVYGVIVAGWASNSKYAFLGALRASAQMVSYELAIGFVLVTVLLVSGSLNMSEIVLGQTRGWFAEHGLTFLSWNWLPLLPLFVIYVISAVAETNRHPFDVVEGESEIVAGHMVEYSGMAFALFFLGEYANMILLSCMASIMFLGGWTSPIDIAPLTWIPGWIWLGIKTFCVVSLFVWFRASFPR... | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t... | A9II17 |
P29068 | CBPT_THEVU | Carboxypeptidase T | Thermoactinomyces | MRKKWLSLSLVLVLIVACVPALGFSQNIENPSIFDLGIKLYKIDGVSTKEQRSAIASTGAAIEEVGKDYVKVLATPSEAKQIKQKGFTATVDTSLTTQDFPSYDSGYHNYNEMVNKINTVASNYPNIVKKFSIGKSYEGRELWAVKISDNVGTDENEPEVLYTALHHAREHLTVEMALYTLDLFTQNYNLDSRITNLVNNREIYIVFNINPDGGEYDISSGSYKSWRKNRQPNSGSSYVGTDLNRNYGYKWGCCGGSSGSPSSETYRGRSAFSAPETAAMRDFINSRVVGGKQQIKTLITFHTYSELILYPYGYTYTDVP... | Able to split off hydrophobic and basic amino acids with comparable efficiency. | P29068 |
Q5E7K1 | RF3_ALIF1 | Peptide chain release factor 3 | Aliivibrio | MSFLQEVGKRRTFAIISHPDAGKTTITEKVLLFGNAIQKAGTVKGRGSNQHAKSDWMEMEKERGISVTTSVMQFPFNDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEDRTRKLMEVTRLRDTPIVTFMNKLDREVRDPMEVLDEVESELGMACAPISWPIGCGKEFKGVYHIHRDETILYESGHGHEIQEVRTIKGLDNPELDATVGADLAESVREELELVMGACPEFDHELFLAGELTPVYFGTALGNFGVDHMLEGLTDWAPAPQTRQANERDVVATEDKFSGFVFKIQANMDPKHRDRIAFMRIVSG... | Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. | Q5E7K1 |
B7LTW5 | PDUL_ESCF3 | Propanediol utilization protein PduL | Escherichia | MDKQLLETAVGKVLEEMRERPIPLGISNRHIHLSAQDFAHLFPGQSISVKKALMQPDQYAAEQTLTLVGPKGKLEKVRLLGPLRSASQVEVSRTDARTLGITAPLRMSGDLQGTPGVRLVSPFAELEITSGVIVAQRHIHMSPLDALILNVSHGDKVSVAIKGDERRLIFDNVAVRVSPDMRLEMHIDTDEANAAGADNPQVCAMLVNKS | Involved in 1,2-propanediol (1,2-PD) utilization within the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. | B7LTW5 |
P37293 | NAT2_YEAST | Amino-terminal, alpha-amino, acetyltransferase 2 | Saccharomyces | MMVPRISASPVFKRIFLRWGFVTLPIQKTVSHTLRRDFSAPCRSMVKCLLLRPGISVHSAQDRKFYSTEEKSSQFDENKSKSNNGKKNEPHGIKGLMAKYGYSALIVYILLTCVDLPLCFLGVHSLGEEKIKIYLNRGKQLIGMGEPDESKVIQDVRRKQAHREAVQAENADKVEDASRKTFNERWQEMKDSTLLAELLIAYGIHKSLIIVRVPLTAVLTPSFVKLLQRFGIDLMKKQKKVFQTMASGAKIRYKGNNPSDFIKNEGTALDITKRKPRTKGQKWFDGLM | Maybe involved in N-terminal acetylation of proteins. N-acetylation plays a role in normal eukaryotic translation and processing, protect against proteolytic degradation and protein turnover. | P37293 |
O83361 | MURC_TREPA | UDP-N-acetylmuramoyl-L-alanine synthetase | Treponema | MKRGTLPKDVSGIKIHMIGIKGTGMSALAELLCARGARVSGSDVADVFYTDRILARLGVPVRTPFSCQNLADAPDVVIHSAAYVPEENDELAEAYRRGIPTLTYPEALGDISCARFSCGIAGVHGKTTTTAMIAQMVKELRLDASVLVGSAVSGNNDSCVVLNGDTFFIAETCEYRRHFLHFHPQKIVLTSVEHDHQDYYSSYEDILAAYFHYIDRLPQFGELFYCVDDQGVREVVQLAFFSRPDLVYVPYGERAWGDYGVSIHGVQDRKISFSLRGFAGEFYVALPGEHSVLNATGALALALSLVKKQYGEVTVEHLTA... | Cell wall formation. | O83361 |
A4J778 | METRE_DESRM | Metal reductase | Desulforamulus | MSILFSPAQIGTLQLRNRIIMTPMHLGYTPNGEVTDQLIEFYRVRARGGAGLIVVGGCGIDRIGNAYGMTQLDDDRFIPGLRRLADAVQAEGAKIVAQLYQAGRYAHSALTGQPAVAPSPIPSKLTGETPVELTEEKIAEIVASFAKAAKRAKTAGFDGVEIIASAGYLISQFLSPLTNKRTDRYGGDLQARMTFGLEVVAAVREAVGSDYPIIVRVAGNDFMPGSHTNTEAQVFCQAMEKSGVNAINVTGGWHETQVPQITMNVPPGAYAYLAYGIKQAVSIPVIACNRINTPDLAEAILQEGKADFIGMARSLMADPE... | Metal reductase able to reduce Fe(III)-chelates to Fe(II)-chelates, as well as soluble Cr(VI) and U(VI), using NADH as electron donor. Cannot use NADPH as an electron donor. Is unable to reduce riboflavin and FMN with NADH as electron donor. May have an in vivo role in metal reduction in D.reducens, which is an organis... | A4J778 |
B5Y6R9 | GCH4_COPPD | GTP cyclohydrolase FolE2 | Coprothermobacter | MRDVQSERDPRNVPLDYVGIENVRLPITVRTKEGGKQPTVGTFSIGVDFPHSFRGTHMSRFMEVLYQHLEEISQTRLRVTLEDIKERLKATKAMIEVAFPFAIKKSTPVTKLETVMYVDASFKAELNSTRGYVVTSTVTVPVHSLCPCSRDISEFGAHNQRVDVTVSWQGDLWIEDVIALVESSASQPLYPLLKRPDEKYVTEKAYLNPKFVEDIAKDLFLKLDPLSPCFRIKVVSYESIHPHNAVAIKEKRAEVSESSVRSNDQEHRDCT | Converts GTP to 7,8-dihydroneopterin triphosphate. | B5Y6R9 |
Q6P7Q1 | BABA2_RAT | Brain and reproductive organ-expressed protein | Rattus | MSPEIALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALHNLASWNPSNPECLLLVVKELVQQYHQFQCGRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKEFCFLVHIDLPLFFPR... | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specific... | Q6P7Q1 |
Q8P2R7 | TADA_STRP8 | tRNA-specific adenosine deaminase | Streptococcus | MPYSLEEQTYFMQEALKEAEKSLQKAEIPIGCVIVKDGEIIGRGHNAREESNQAIMHAEMMAINEANAHEGNWRLLDTTLFVTIEPCVMCSGAIGLARIPHVIYGASNQKFGGADSLYQILTDERLNHRVQVERGLLAADCANIMQTFFRQGRERKKNS | Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2). | Q8P2R7 |
A3CVJ2 | PCNA_METMJ | Proliferating cell nuclear antigen homolog | Methanoculleus | MLKATIDAEIFRESIDAIAALVTECRLHTAEDQIRTRSVDTANVAMVSLELQSTAFNSFSATAGELGLDIAKMKNIIGMMGKGDALTLTLLDEERKLELSFGGYRYSISLLDVNTIRKDPNPPGIDLPGKAVVPGDALNNAIKAAAVISDKIALGIDPDAMTFYMEAEGDTDHIKLALGEDELVALSPVQARSLFSIDYLKDMGRVMARADKVEVYLGIDHPVRFVFDIADGNGRVEYLLAPRIEAD | Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. | A3CVJ2 |
Q8VF12 | OL495_MOUSE | Olfactory receptor 204-37 | Mus | MAFLEDGNHTIVTEFILLGLTDDPVLRDILFTIILCIYLVTVSGNLSTILLIRVSSQLHHPMYFFLSHLASVDIGISSSVTPNMLANFLVKPNTISYIGCSIQFTSAVFLATVECFLLAAMAYDRFVAICNPLLYSTKMSREACIQLVVGSYIQGLLNASFFTLSFFSLIFCGPNRINHFYCDLAPLVELSCSDVTLAVVITSISAGFITLTTVFVIAISYSCIFITIMKMHSTESRYKAFSTCTSHLTAVTLFYGTTMFIYVMPKSSYSTDQNKVLSVFYMVVIPMLNPLIYSLRNNEIKGALKRYLGKKIFSYGNLFC... | Potential odorant receptor. | Q8VF12 |
C1CTY2 | MUTS_STRZT | DNA mismatch repair protein MutS | Streptococcus | MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLIEQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVSIDREGNQFGLAYMDLVTGDFYVTGLLDFTLVCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQTASSKLLQYVHRTQMRELNHLKPVIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFF... | This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | C1CTY2 |
Q4UJN0 | LPXB_RICFE | Lipid-A-disaccharide synthase | spotted fever group | MTKIYFIAGETSGDFIGGRIIQHLKDNIEIKCMGVGGKYMEEAGSFKSLFSITSINLMGFVEILPHIFKLKKLIDKTVEDITNSRADLLITIDSPGFTYRVAKRVRKLLPKLKMIHIVAPSVWAYKEDRAVKYAQIYDCLFALLPFEPPYFTRLGLDCRYIGHPIMEQEFYSDKVALRKEFKIDENERVLCVTLGSRKGEILRHLPVFVSSIEEIFKSCNNLKVIFTLANPAHEAIIKPFLEDVKFNYLFSSERLKTYAVADAALAKSGTNTLEIAASGTPMIVAYKVNLISFFIIRLLIKIKYVTLINIIAGSEIIPEF... | Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | Q4UJN0 |
Q9Z8T3 | RIMO_CHLPN | Ribosome maturation factor RimO | Chlamydia | MTTKSLGSFNSVISKNKIHFISLGCSRNLVDSEVMLGILLKAGYESTNEIEDADYLILNTCAFLKSARDEAKDYLDHLIDVKKENAKIIVTGCMTSNHKDELKPWMSHIHYLLGSGDVENILSAIESRESGEKISAKSYIEMGEVPRQLSTPKHYAYLKVAEGCRKRCAFCIIPSIKGKLRSKPLDQILKEFRILVNKSVKEIILIAQDLGDYGKDLSTDRSSQLESLLHELLKEPGDYWLRMLYLYPDEVSDGIIDLMQSNPKLLPYVDIPLQHINDRILKQMRRTTSREQILGFLEKLRAKVPQVYIRSSVIVGFPGE... | Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12. | Q9Z8T3 |
Q8ZMF5 | CYSN_SALTY | Sulfate adenylate transferase | Salmonella | MNTILAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTLQIYEDQLSSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTERRKFIIADTPGHEQYTRNMATGASTCDLAILLIDARKGVLDQTRRHSFISTLLGIKHLVVAINKMDLVDYREETFARIREDYLTFAEQLPGDLDIRFVPLSALEGDNVAAQSANMRWYSGPTLLEVLETVDIQRAVDRQPMRFPVQYVNRPNLDFRGYAGTLASGSVKVGERIKVLPSGVESSVARIVTFDGDKEEACAGEAITLVLNDDIDISR... | With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysi... | Q8ZMF5 |
Q9LVB0 | AHL6_ARATH | AT-hook motif nuclear-localized protein 6 | Arabidopsis | MEEKGEISPSGVVTVKGDEALVPRTEFQQNPSFLQFVSPTTVVTPLPPPPAPSSAPVPTTVTPGSATASTGSDPTKKKRGRPRKYAPDGSLNPRFLRPTLSPTPISSSIPLSGDYQWKRGKAQQQHQPLEFVKKSHKFEYGSPAPTPPLPGLSCYVGANFTTHQFTVNGGEDVTMKVMPYSQQGSRAICILSATGSISNVTLGQPTNAGGTLTYEGRFEILSLSGSFMPTENGGTKGRAGGMSISLAGPNGNIFGGGLAGMLIAAGPVQVVMGSFIVMHQAEQNQKKKPRVMEAFAPPQPQAPPQLQQQQPPTFTITTVN... | Transcription factor that specifically binds AT-rich DNA sequences related to the nuclear matrix attachment regions (MARs). | Q9LVB0 |
A4XVG4 | LPXH_PSEMY | UDP-2,3-diacylglucosamine diphosphatase | Pseudomonas | MILLISDLHLEEKRPDITRAFLHFLATRARQAEALYILGDFFEVWIGDDGMTPFQHEIAGALRELSDSGTRIYLMHGNRDFLIGKRFCREAGCTLLGDPHRVQMNGEPVLLMHGDSLCTLDVGYMKLRRWLRNPLSLLILRNLPLATRQKLARKLRNESRAQTRMKASEIVDVTPEEVVRVMGEYDVRTLIHGHTHRPAVHELEVNGQPARRIVLGDWDRQGWALQVDGEGFNQAPFELTPA | Hydrolyzes the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. | A4XVG4 |
Q8FBP9 | WECF_ECOL6 | TDP-Fuc4NAc:lipid II Fuc4NAc transferase | Escherichia | MTVLIHVLGSDIPHHNRTVLRFFNDALAATSEHAREFMVAGKDDGLSDSCLALSVQFFPGKKSLAEAVIAKAKANRQQRFFFHGQFNPKLWLALLSGGIKPSQFFWHIWGADLYELSSGLRYKLFYPLRRLAQKRVGCVFATRGDLSFFAKTHPKVRGELLYFPTRMDPSLNTMANDRQREGKMTILVGNSGDRSNEHIAALRAVHQQFGDTVKVVVPMGYPPNNEAYIEEVRQAGLELFSEENLQVLSEKLEFDAYLTLLRQCDLGYFIFARQQGIGTLCLLIQAGIPCVLNRENPFWQDMTEQHLPVLFTTDDLNEDI... | Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis. | Q8FBP9 |
Q83HY0 | ATPB_TROW8 | F-ATPase subunit beta | Tropheryma | MTGDAVGRIVRVTGSVVDVEFSRNNLPGVFNALKTRVNRSGKEIEITLEVAQHLGDDLVRTVAMQSTDGLIRGQEVLDTGGHITVPVGDATKGRVFNVVGEVLNSNGEDIKFDEYWSIHRKPPEFSLLESKTQLFETGIKVIDLLTPYVQGGKIGLFGGAGVGKTVLIQEMIQRVAQDHGGVSVFAGVGERTREGNDLIREMQDAGVFDKTALVFGQMDEPPGTRLRVALSALTMAEYFRDVQKQDVLLFIDNIFRFTQAGSEVSTLLGRIPSAVGYQPNLADEMGVLQERITSTRGHSITSLQAIYVPADDYTDPAPAT... | Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. | Q83HY0 |
P18296 | CUT1_SCHPO | Separase | Schizosaccharomyces | MSTRSIVTSKVSWTPEKFISALSYPEHCSITLVKRLKASVKLKDLKQNISRDAPSWTFEHLFVAFKCAVSNLAKQWAELSTTDKEKTRRMFCTPSRLNTAHRPEVFYLLECCTYILEQMQVVTKNTSHLYDCIRSGVSICNRLLDMEIFEPAISLLMKTHKNLIILLTYRDHDAIPTATLLNPTLDVSEIQLESCLFVPMVPASYFLNIGTIVVTFQLNVLRCLSLSQINGLSLNTINNLQSEDGPFQWIERSFPSQVQLANSRREILARLLTRFSMIQNNALQSFKLLILSIALWLNILSSQRADDKEFDVNQLETRIL... | Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the rad21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by securin/cut2 protein. It is also required for pointed nuclear formation. | P18296 |
Q7VQX1 | HIS1_BLOFL | ATP phosphoribosyltransferase | Candidatus Blochmannia | MLDKSRLRIAMQKSGRLSKESQKLLEQCGIKINLQQQQLLAFAENMTIDIMRVRDDDIPGLIMDGVVDLGIIGENVLEEALLTRQSQGDNPCYVTLRRLDFGDCRLSMALPMDKPWNGPKCLQGKRIATSYPHLLKQYLDKLGINFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEANGLREVEVIYRSKACLIQRSGNLSKTKQSLIDKLMIRIQGVIQARESKYIMLHAPAERLEEIINLLPGAESPTVLPLAGNQHRVAIYMVSNEALFWETMENLKNLGASSILVLPIEKMME | Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | Q7VQX1 |
P20802 | TBB_ACHKL | Beta-tubulin | Achlya | MRELVHIQGGQCGNQIGAKFWEVISDEHGVDPTGSYHGDSDLQLERINVYYNEATGTYVPRAILMDLEPGTMDSVRAGPYGQLFRPDNFVFGQTGAGNNWAKGHYTEGAELIDSVLDVVRKEAESCDCLQGFQITHSLGGGTGSGMGTLLISKIREEYPDRIMCTYSVCPSPKVSDTVVEPYNATLSVHQLVENADEVMCLDNEALYDICFRTLKLTNPTYGDLNHLVCAAMSGITTLLRFPGQLNSVLKLAVNLIPFPRLHFFMIGFAPLTSRGSQQYRALTVPELTQQQFDAKNMMCAADPRHGRYLTAACMFRGRMS... | Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-... | P20802 |
P59108 | CPNE2_MOUSE | Copine II | Mus | MAYIPDGGAPTAGAIPLGSQCCVCKVELSVSGQNLLDRDVTSKSDPFCVLFIEDNGRWMEFDRTETAVNNLNPAFSKKFVLDYHFEEVQKLKFALFDQDKSSAQLDEHDFLGQFSCSLGTIVSSKKITRPLLLMNDKPAGKGVITIAAQELSDNRVITLSLAGRKLDKKDLFGKSDPFLEFYKPGDDGKWMLVHRTEVIKYTLDPVWKPFTVPLVSLCDGDLEKPIQVMCYDYDSNGGHDFIGEFQTSVLQMSEARDGVPLEIECINPKKQRKKKSYKNSGIIILRSCKIHRNYSFLDYILGGCQLMFTVGIDFTASNGN... | Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties . | P59108 |
A8LRT3 | ALR_DINSH | Alanine racemase | Dinoroseobacter | MATATLSIDLDAIAANWRALDRASNRRVATGAVVKADGYGLDAGRVARTLAQAGARQFFVAVAEEGVTLRKALGPGPAINVFSGHMEGDTQAIAGARLTPMINSAEQLARHFEALPRHPFGIQLDTGMNRLGMEADEWAAVAEFALGQGPKLVMSHLACADEPGHAANAAQLAEFHRLTDGITVPRSLSATGGILLGEAYHFDMTRPGIGLYGGAPFGAAEPVVRLSIPVVQVRAVTAGESVGYGCSWVAQSDGAIATLSAGYADGLIRAMSNRAMLYAGDVACPLAGRVSMDLLTVDVSHLDEVPEALDLLCPAQGVDR... | Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. | A8LRT3 |
Q11KP9 | KATG_CHESB | Peroxidase/catalase | unclassified Chelativorans | MDAKTDDSAGKCPFTGGGRRGHRNRDWWPEQLDLDVLHRNSTLSDPMGEDFDYAEEFKSLDLNAVIQDLHALMTDSQDWWPADFGHYGGLMIRMAWHSAGTYRITDGRGGAGAGQQRFAPLNSWPDNANLDKARRMLWPIKQKYGRKISWADLMILAGNVALESMGFKTFGFAGGRKDVWEPEELFWGPEGTWLGDERYSGERQLSEPLAAVQMGLIYVNPEGPNGNPDPVAAAKDIRETFYRMAMNDEETVALIAGGHTFGKTHGAGDPSLIGPDPEGAAIEDQGLGWKSGHGTGFGADTITGGPEVTWSQTPTRWSNY... | Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. | Q11KP9 |
P13911 | RPOA_PEA | Plastid-encoded RNA polymerase subunit alpha | Pisum | MIREKLKVSTQTLQWKCVESRVDSKRLYYGRFILSPLMKGQADTIGITMRRILLGEIEGTCITRAKSEKIPHEYSTIVGIQESIHEILMNLKEIVLRSNLYGTREASICFKGPGYVTAQDIILPSVEVIDNTQHIANLTEPINLCIELQIERKRGYRIKTLNNIQDGSYTIDAVFMPVRNANHSIHSYVNGNQKQEILFLEIWTNGSLTPKEALYEASRNLIDLFIPFLHAEEENLNFENNQHKMTLPLFTFHDHDRFVKDKLRKNQKEITLKSIFIDQLELPPRIYNCLKKSNIHTVLELLNKSQEDLMKIEHFRVEDL... | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | P13911 |
A7H644 | RL5_CAMJD | 50S ribosomal protein L5 | Campylobacter | MMRLKEKYNQSIKPALVKEFDIKNPMLIPVIEKVVISVGAGELAKDQKVLQNVADTISLIAGQKAVITKAKKSVAGFKVREGFPIGVMVTLRKENMYAFLDKLISIALPRVKDFRGLSRDGFDGRGNYNFGLDEQLMFPEVEYDKILRTHGMNISIVTTAQNDKQAQKLLELIGVPFTKGK | This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement... | A7H644 |
E7FHN9 | HYD2B_PYRFU | Sulfur reductase subunit ShyB | Pyrococcus | MRYVKLHSEYFPEFFNRLKEVGRVYGPVRHNSTYRFEEVNSIDELSLDYTRTILPPKKFFIRPRDAMFKIQKNEVTEVDGDGKFVLFGVHSCDIHGIKILDKVYLSNPPDPYYERRRKNAFIVGISCMPDEYCFCKSLGTDFAMDGFDIFLHELPDGWLVRVGSVKGHEFVWENQDIFDDVTEEDLRNFKEFEEKRAKAFKKSLNKEGLADILDLAFTSKVWKKYAEKCLGCGNCTIVCPTCRCYEVCDTWVRAYEALRMRRYDSCFMPTHGLVAGGHNFRPTRLDRFRHRYYCKNYFDPEAGFNCVGCGRCDEFCPARI... | Part of a bifunctional enzyme complex that functions as a hydrogen-evolving hydrogenase with sulfur-reducing activity. May play a role in hydrogen cycling during fermentative growth. Activity exhibited with NAD in addition to NADPH. The beta and gamma subunits form the sulfur-reducing component that catalyzes the cytop... | E7FHN9 |
B2GC51 | RNH2_LIMF3 | Ribonuclease HII | Limosilactobacillus | MSKQSVAQVRALLSSITDPQDPRLAEFKDDPRKGVQAALNQFAKRLEKRAEARAAFLNRFRYENQLWQAGHQYVAGIDEVGRGPLAGPVVTCAVVLDSQFDLVGVTDSKQLSRHEREQLYLRILDEAVEVSLAVSPAQEIDRLNIYAATQTAMIRSVKALHHQPSHLIVDAVPLDIPVPQTTLIKGDQKSISVAAASIVAKEYRDHLMAIYDRLYPGYGFKDNMGYGTAAHLAGLEQLGACPIHRRTFRPVPDYVN | Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. | B2GC51 |
Q481S6 | GLYA2_COLP3 | Serine hydroxymethyltransferase 2 | Colwellia | MFYKNDQIAGFDDSIWQAMEQEDKRQQDHVELIASENYTSARVMQAQGSQLTNKYAEGYPGKRYYGGCEHVDVIEQLAIDRAKELFGADYANVQPHSGSQANAAVFMALLKPGETVLGMSLAHGGHLTHGSKVSFSGKIYNAVQYGLNEATGEIDYEEVERLAKEHQPKMIIAGFSAYSRVVDWQRFRDIADSIGAWLFVDMAHVAGLVAAGLYPNPVPIADVVTTTTHKTLRGPRGGLILAKQNDELAKKLNSAVFPAGQGGPLMHVIAAKAICFKEALGEGYVEYQQQVIDNAREMAKTFQTRGYNVVSGGTDNHLFL... | Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent a... | Q481S6 |
Q09FZ1 | NU1C_PLAOC | NADH-plastoquinone oxidoreductase subunit 1 | Platanus | MIIDTTEVQAINSFSRSESLKEAYGLIWLLVPIFTPVSGITIGVLVIVWLEREISAGIQQRIGPEYAGPLGILQALADGTKLLFKEDLLPSRGDTRLFSIGPSIAIISILLSYSVIPFGYRLVLADLSIGVFLWIAISSIAPIGLLMSGYGSNNKYSFSGGLRAAAQSISYEIPLTLCVLSISLLSNSLSTVDIVEAQSKYGFWGWNLWRQPIGFAVFLISSLAECERLPFDLPEAEEELVAGYQTEYSGIKFGLFYVASYLNLLVSSLFVTVLYLGGWNLSIPYIFIPELFEINKVSGVFGTTIGIFITLAKAYLFLFI... | NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translo... | Q09FZ1 |
Q04911 | CYB_MONDO | Ubiquinol-cytochrome-c reductase complex cytochrome b subunit | Monodelphis | MTNLRKNYPLMKIINHSFIDLPAPSNISAWWNFGSLLGMCLIIQILTGLFLAMHYTSDTLTAFSSVAHICRDVNYGWLIRNLHANGASMFFMCLFLHVGRGIYYGSYLYKETWNIGVILMLTVMATAFVGYVLPWGQMSFWGATVITNLLSAIPYIGNTLVEWIWGGFSVDKATLTRFFAFHFILPFIILALVIVHLLFLHETGSNNPTGINPNSDKIPFHPYYTIKDALGLILMLLILMSLAMFSPDMLGNPDNFTPANPLNTPPHIKPEWYFLFAYAILRSIPNKLGGVLALLASLLILLIIPLLHTSKQRSLMFRPI... | Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is... | Q04911 |
Q82TP1 | UBID_NITEU | Polyprenyl p-hydroxybenzoate decarboxylase | Nitrosomonas | MKYKDLRDFLVQLEQRGDLKRVDIEVDPHLEMTEICDRLLKQAGPAVLFERPAGHTIPVLGNLFGTPERVALGMGQTSVSALREVGKLLAYLKEPDPPKGLRDAWEKLPVLKQVLNMAPKQLASAPCQEIIWEGADVDLGKLPIQTCWPGDVAPLITWGLTVTRGPHKSRQNLGIYRQQVIAPNKVIMRWLAHRGGALDYRDFCQIYPGQPYPVAVALGADPATILGAVTPVPDSLSEYQFAGLLRGAKTEVVKCLTHDLQVPASAEIVLEGYIHPDEMAVEGPYGDHTGYYNEQETFPVFTIERITMRRNPIYHSTYTG... | Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | Q82TP1 |
B9KH09 | ATPA_ANAMF | F-ATPase subunit alpha | Anaplasma | MSIVSSGDILKILKERIEGFDSPVKTSSVGDVVAIKDGIALVYGLSGVKFGETVAFSSGVRGVVAGLERDTCSVVVFGEDREIREGDSVQCTGELMTVPAGLSVLGRVVNPLGSPVDGGNAIVADSRLPVEAKAPGIMARQPVCEPLQTGIKTVDMLIPIGRGQRELVIGDRKTGKTAIALDTIINQKKTNDTADAKNRMYCIYVAIGQKNSSIARVVHKLKETGAMDYTIVVAAGASDPVSIQYLAPYAACAMGEFFRDNGMHCLIVYDDLSKHAVAYRQMSLLLRRPPGREAYPGDVFYIHSRLLERAAKLSDDLGGG... | Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. | B9KH09 |
Q60773 | CDN2D_MOUSE | p19-INK4d | Mus | MLLEEVCVGDRLSGAAARGDVQEVRRLLHRELVHPDALNRFGKTALQVMMFGSPAVALELLKQGASPNVQDASGTSPVHDAARTGFLDTLKVLVEHGADVNALDSTGSLPIHLAIREGHSSVVSFLAPESDLHHRDASGLTPLELARQRGAQNLMDILQGHMMIPM | Interacts strongly with CDK4 and CDK6 and inhibits them. | Q60773 |
P24718 | RECF_ACTPL | DNA replication and repair protein RecF | Actinobacillus | MPLSRLIINNFRNLQSLDLELSPNFNFIVGHNGSGKTSLLEAIFYLGHGRSFKSHISNRIIHYQAEDFVLHARIDEGQHQWSVGIQKKRSGDTLLKINGEDGNKISDLAHLLPMQVITPEGLTLLNGGPTFRRAFLDWGLFHQYTEFYSCWANLKRLLKQRNAALHQVRSYAELKPWDIELAKLAEIVSQMRASYAEGLRPEIEKTCQFFLPELEIGVSFHQGWEKGTDYAEILAQGFERDKAMGYTMIGPQKADFRFRANGLPVEDVLSRGQLKLLMCALRLAQGEYLVAQKERQCLFLIDDFASELDPIKRELLAHRL... | The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | P24718 |
Q3KP22 | MAJIN_HUMAN | Membrane-anchored junction protein | Homo | MSLKPFTYPFPETRFLHAGPNVYKFKIRYGKSIRGEEIENKEVITQELEVPVEKKAVGAVMRKRKHMDEPSSPSRPGLDRAKIGTSSQGPSKKKPPVETRRNRERKTQQGLQETLASDITDVQKQDSEWGHSLPGRIVPPLQHNSPPPKERAATGFFGFLSSLFPFRYFFRKSSHS | Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane ... | Q3KP22 |
D0LHE3 | BMCT1_HALO1 | Bacterial microcompartment protein trimer-1 | Haliangium | MDHAPERFDATPPAGEPDRPALGVLELTSIARGITVADAALKRAPSLLLMSRPVSSGKHLLMMRGQVAEVEESMIAAREIAGAGSGALLDELELPYAHEQLWRFLDAPVVADAWEEDTESVIIVETATVCAAIDSADAALKTAPVVLRDMRLAIGIAGKAFFTLTGELADVEAAAEVVRERCGARLLELACIARPVDELRGRLFF | A minor component of the bacterial microcompartment (BMC) shell. Expression of 5 proteins in E.coli (BMC-H (Hoch_5815), BMC-P (Hoch_5814), and 3 BMC-T (Hoch_5812, Hoch_5816, Hoch_3341)) forms 40 nm artificial BMCs with a molecular mass of 6.5 MDa. This protein does not form stacked pseudohexamers in the BMC. There are ... | D0LHE3 |
Q3BVY7 | RL19_XANC5 | 50S ribosomal protein L19 | Xanthomonas | MSKLNKTILADFEAAQIQRKLPEFNQGDTVVVNVKVKEGNRERVQAYEGVVIGTKNAGLNSSFTVRKISHGFGVERVFQTHSAIIDSVEVKRRGKVRAGKLYYLRGLEGKAARIKEDLAAAAQAKAARQAAAKVE | This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | Q3BVY7 |
P16451 | ODPX_YEAST | Pyruvate dehydrogenase complex component E3BP | Saccharomyces | MLSAISKVSTLKSCTRYLTKCNYHASAKLLAVKTFSMPAMSPTMEKGGIVSWKYKVGEPFSAGDVILEVETDKSQIDVEALDDGKLAKILKDEGSKDVDVGEPIAYIADVDDDLATIKLPQEANTANAKSIEIKKPSADSTEATQQHLKKATVTPIKTVDGSQANLEQTLLPSVSLLLAENNISKQKALKEIAPSGSNGRLLKGDVLAYLGKIPQDSVNKVTEFIKKNERLDLSNIKPIQLKPKIAEQAQTKAADKPKITPVEFEEQLVFHAPASIPFDKLSESLNSFMKEAYQFSHGTPLMDTNSKYFDPIFEDLVTLS... | Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. | P16451 |
B1LEG3 | OPGB_ECOSM | Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase | Escherichia | MSELLSFALFLASVLIYAWKAGRNTWWFAATLTVLGLFVVLNITLFASDYFTGDGINDAVLYTLTNSLTGAGVSKYILPGIGIVLGLTAVFGALGWILRRRRHHPHHFGYSLLALLLALGSVDASPAFRQITELVKSQSRDGDPDFAAYYKEPSKTIPDPKLNLVYIYGESLERTYFDNEAFPDLTPELGALKNEGLDFSHTQQLPGTDYTIAGMVASQCGIPLFAPFEGNASASVSSFFPQNICLGDILKNSGYQNYFVQGANLRFAGKDVFLKSHGFDHLFGSEELKSVVADPHYRNDWGFYDDTVLDEAWKKFEELS... | Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones. | B1LEG3 |
Q9I1W9 | RGVIR_PSEAE | Putative virulence-regulating protein PA2146 | Pseudomonas | MAQHQGGKGNFAEDPKRASEAGKKGGQASGGNFKNDPQRASEAGKKGGQRSHGGN | May be involved in the regulation of the production of pyocyanine, one of the major virulence factors secreted by P.aeruginosa, and other virulence factors. | Q9I1W9 |
Q8XEC1 | MHPD_ECO57 | 2-hydroxypentadienoic acid hydratase | Escherichia | MTKHTLEQLAADLRRAAEQGEAIAPLRDLIGIDNAEAAYAIQHINVQYDVAQGRRVVGRKVGLTHPKVQQQLGVDQPDFGTLFADMCYGDNEIIPFSRVLQPRIEAEIALVLNRDLPATDITFDELYNAIEWVLPALEVVGSRIRDWSIQFVDTVADNASCGVYVIGGPAQRPAGLDLKNCAMKMTRNNEEVSSGRGSECLGHPLNAAVWLARKMASLGEPLRAGDIILTGALGPMVAVNAGDRFEAHIEGIGSVAAAFSSAAPKGSLS | Catalyzes the conversion of 2-hydroxypentadienoic acid (enolic form of 2-oxopent-4-enoate) to 4-hydroxy-2-ketopentanoic acid. | Q8XEC1 |
C4ZZN7 | MUTS_ECOBW | DNA mismatch repair protein MutS | Escherichia | MSAIENFDAHTPMMQQYLRLKAQHPEILLFYRMGDFYELFYDDAKRASQLLDISLTKRGASAGEPIPMAGIPYHAVENYLAKLVNQGESVAICEQIGDPATSKGPVERKVVRIVTPGTISDEALLQERQDNLLAAIWQDSKGFGYATLDISSGRFRLSEPADRETMAAELQRTNPAELLYAEDFAEMSLIEGRRGLRRRPLWEFEIDTARQQLNLQFGTRDLVGFGVENAPRGLCAAGCLLQYAKDTQRTTLPHIRSITMEREQDSIIMDAATRRNLEITQNLAGGAENTLASVLDCTVTPMGSRMLKRWLHMPVRDTRV... | This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. | C4ZZN7 |
Q8DSG6 | GATB_STRMU | Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B | Streptococcus | MNFETIIGLEVHVELKTNSKIFSPAPAHFGEDPNANTNIVDWSFPGVLPVMNKGVIDYGIKAALALNMDIHQRMHFDRKNYFYPDNPKAYQISQFDEPIGYNGWIEIELEDGSTKKIRIERAHLEEDAGKNTHGADGYSYVDLNRQGVPLIEIVSEADMRSPEEAYAYLTALKEIIQYTGISDVKMEEGSMRVDANISIRPYGQEAFGVKTELKNLNSFNFVRRGLAYEEKRQAEVLRSGGQIQQETRRYDEATGETLLMRVKEGSADYRYFPEPDLPIFEIEDEWIEKVRAELPAFPKERRAKYVNDLGLSAYDAAQLT... | Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated ... | Q8DSG6 |
B0SAC5 | PANB_LEPBA | Ketopantoate hydroxymethyltransferase | Leptospira | MKNIILQYKKKYDAGEPISVVTCYDYTFATLFNRTDVDCLLVGDSLGMVIQGNQSTLPVTLDEIIYHTKAVCKGAPDKTIIADLPFLSYQTSIEEGIRSAGRVLKETNASCVKLEGDSEFIIELTKRMTESGIPVFAHLGLTPQSVHTLGGHRVQGKTEAARNKMIRKSRELAEAGAFALLLEMVPESLGKEITESIRIPTIGIGAGKYTSGQVLVMQDLLGLNEDFHPKFLKKFGNLSGAVKEAVNAYHKEVTKREYPSEAHVFLDT | Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. | B0SAC5 |
B6JGU6 | TIG_AFIC5 | PPIase | Afipia | MQVNETLSEGLKHEFQISIPAAEIDAKVNERLAGMKDKVRLNGFRPGKVPVAHLKKVYGKSVAAETLEETIRETNQKIFTDRGFRLANEAKVTMPTDQAEIEGILDGKKDLTYSVAIEVVPPITLADFKTFKVEKLVADVTDAEVDDAIKRIADQNRPYAPKSEGAKAENGDRVTLAFKGTIDGEAFEGGSGENIPLVLGSNSFIPGFEDQLTGIGVGETRVIKVPFPKNYGAAHLAGKDAEFETTATLIEAPQDATIDDEFAKTLGVESLDKLKEAMRERLTQEYAGATRQKLKRELLDRLDETHKFDPPESLVNDEFD... | Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. | B6JGU6 |
Q2NHB4 | TRUA_METST | tRNA-uridine isomerase I | Methanosphaera | MRRVALKIAYIGSNFHGYQRQPNYRTVEGELLRVFKETNIIEDTWTAHYSVAGRTDKGVHSTGNVISFITDEDIHINQLNGLLPDDIKIIGEARVPYGFKVRFPLTRTYTYIQPISPFEKKNLDITKMHVAMESFIGKHNFRNFSKRNEKNPNRKIIDVNLEVDEDVLIFTIVGESFLWNMVRKMVTSIMEVGYGKLDINDINELLKPKELRQFIRLQPAPANGLILSDMEYKNIKFKDSEYAKNKLVEFLKKEYMLHEQEKKADCRLIKILKK | Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | Q2NHB4 |
Q8KBK4 | RL13_CHLTE | 50S ribosomal protein L13 | Chlorobaculum | MSKTLSFKTYSAKPGEVKRTWHIIDAENQVLGRMAAQIANVLRGKHKPQFTPHIDTGDFVVVTNAAKVALSGKKRDDKTYFSHSHYPGGVRIDSVKDLLQKKPEKVIEHAVWGMLPHNNLGRQLFKKLKVYAGPEHPHAAQMPVEMKINQ | This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. | Q8KBK4 |
A4QLM9 | RR8_LOBMA | 30S ribosomal protein S8, chloroplastic | Lobularia | MGKDTIADIITSIRNADMNRKGTVRIGSTNITESIVKILLREGFIENVRKHRENNQYFLILTLRHRRNKKESHKTILNLKRISRPGLRIYSNSQRIPRILGGIGIVILSTSQGIMTDREARLKRIGGEILCYIW | One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit. | A4QLM9 |
B1KRQ3 | RF3_SHEWM | Peptide chain release factor 3 | Shewanella | MSGNKVEVDKRRTFAIISHPDAGKTTITEKVLLFGNALQKAGTVKGKKSGQHAKSDWMEMEKDRGISITTSVMQFPYNDALVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDSAKGVEQRTIKLMEVTRLRDTPIVTFMNKLDRDIRDPLELMDEVEEVLNIACAPITWPISSGKEFKGVYHLLRDEVILYQSGQGHTIQDSRIIKGLNNPELDEAIGAYAAEVREELELVLGASNEFDLEMFLAGELTPVFFGTALGNFGVDHILDGIVEWAPKPQARETEVRDIQPEDEKFSGFVFKIQANMDPKHRDRVAFMRICSG... | Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. | B1KRQ3 |
Q6L6X6 | IL6_TAKRU | Interleukin-6 | Takifugu | MASISYLLAPLVLAAVLQPTAGAPLDAPTESPAGETSGEEAETGSPDDALAVALESVLGATKLHKNEFLVEFQGEVKYDFLDRYKIPSLPAKCPYSNFGKDACLRRLLEGLLIYSVLLKRVEEEFPSSSILSEVRFYSNILIKELENKVRDRDQVMRLTSSQEEQLLKDTDYPDTFHRKMTAHGILYNLHYFLVDCRRVINKRAKHRESAGSRVVRAVTFYHPKKRS | Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling'... | Q6L6X6 |
Q31XA7 | TRUD_SHIBS | tRNA-uridine isomerase D | Shigella | MIEFDNLTYLHGKPQGTGLLKANPEDFVVVEDLGFEPDGEGEHILVRILKNGCNTRFVADALAKFLKIHAREVSFAGQKDKHAVTEQWLCARVPGKEMPDLSAFQLEGCQVLEYARHKRKLRLGALKGNAFTLVLREVSNRDDVEQRLIDICVKGVPNYFGAQRFGIGGSNLQGALRWAQTNTPVRDRNKRSFWLSAARSALFNQIVAERLKKADVNQVVDGDALQLAGRGSWFVATTEELAELQHRVNDKELMITAALPGSGEWGTQRKALAFEQAAVAAETELQALLVREKVEAARRAMLLYPQQLSWNWWDDVTVEI... | Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. | Q31XA7 |
Q92QI0 | RL1_RHIME | 50S ribosomal protein L1 | Sinorhizobium | MAKIAKRVQKSREGVDPTKLYGLTEAVTLVKERATAKFDETIEVAMNLGVDPRHADQMVRGVVNLPNGTGRSVRVAVFARGAKADEAKAAGADVVGAEELVEIVQGGKIDFDRCIATPDMMPLVGRLGKVLGPRGMMPNPKVGTVTMDVTGAVKASKGGAVEFRVEKAGIVHAGIGKASFDAKALEENIRAFADAVIKAKPTGAKGNYVKRVAVSSTMGPGLKVDPATISAA | Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. | Q92QI0 |
Q3Z800 | NUOB_DEHM1 | NDH-1 subunit B | Dehalococcoides | MELDSGKPLSLLTLDEIDQHEGGIIQSFRTGHTTPYPDPADWLNSEEPPPGVFVTSVEKVLNWSRHYSLWPVMFGLACCAIEMMCMAASRWDLARFGMDIFRASPRQADLMIVAGTLTWKMAPWLKRIYDQMPEPKWVLAMGACGTSGGLFRDSYSVVPGFNMVVPVDVYVPGCPPRPEALLRAIMDIHEKIDKTRIIKR | NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are t... | Q3Z800 |
Q9U2M4 | HOT_CAEEL | 3-Hydroxypropionate-oxoacid transhydrogenase | Caenorhabditis | MSASLARGILSKMGGSCCPHHAPATNPFKLAKLHGNNKSTDYAFEMVCSTLRFGKGVTLEIGYDVRNLGAKKTLLITDKNVQNTIAFKNAEQALKMVNIEYEVFDDVLIEPTVNSMQKAIAFAKSKQFDSFIAVGGGSVIDTTKAAALYASNPEADFLDFVGPPFGKSMQPKNPMLPLIAVPTTAGTGSETTAAAIMDLPEHKCKTGIRLRCIKPYLAVVDPLNVMSMPRNVAIYSGFDVLCHALESFTALPFDQRSPRPENPGVRPLYQGSNPISDVWSKEALRIIGKYFRRSIFDPTDEEARTEMLKASSFAGIGFGN... | Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formatio... | Q9U2M4 |
D7UTD1 | BSC9_ALTBR | null | Alternaria sect. Brassicicola | MASTSSTSTDGHLNIRPMVHGSDKKLNFGAYITGLDLNNASDAEVDQLREAILRHKIVVIKGQQAEKPDKNWEMIKKLDPMHHMITQEEFGQLFHPTGEGLIAMLKLATVPTTEHGHIHLMGKGYQGDDHYGLKKLNLGEAFAGNYYSKPLAEEDFRAGVTRFQSWHMDGPLYKVHPPYISSLRFIQLPDGEQTVEWADGSGLSLKTKPGRTAFFSTSQLYDMLTDEERAMVDNSAVEYMYYPYEWIRGCRGNPNGLNVADEGREKPLDAMEEIARDERWTKTYPMVWFNELTKEKSLQVQPNCVRRLLIRRSADQKEPE... | Alpha-ketoglutarate dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of the diterpene glucoside brassicicene C . In the first step of the brassicicene C biosynthesis, the bifunctionnal diterpene synthase bsc8 that possesses both prenyl transferase and terpene cyclase activity, converts iso... | D7UTD1 |
Q2U038 | KYNU1_ASPOR | L-kynurenine hydrolase 1 | Aspergillus subgen. Circumdati | MGSRLHVQEIKKGPPLPFKDDIRAFTREYAESLDAQDPLRHFRDEFIIPSKKDLKRKTLNANENIEDSSDPRSIYLCGNSLGLQPRNTRKYLEHYLRTWAIKGVTGHFTPHDDQLLPPFVDVDDAGAKLMAPIVGALESEVAVMGTLTANLHFLMASFYQPTKEKYKIILEGKAFPSDHYAVESQIQHHNLDPKDAMVLIELENLDRPILDTEKILRVIDEHASSTALILLSGIQFYTGQYFDIEKITAYAHSKGIIIGWDCAHAAGNVELKLHDWNVDFAAWCNYKYLNSGPGGMAGLFVHENHGRVDMTKVGSKDEPF... | Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. | Q2U038 |
Q9CD75 | G6PI_MYCLE | Phosphohexose isomerase | Mycobacterium | MTSMQAIPDITATPAWDALRRHHDEIGATHLRQFFADNPNRGRELVITVGDLYIDYSKHRITHDTVQLLVDLARAANLEQRRDQMLAGVHVNTSENRSVLHTALRLPRDTELIVDGQNVVQDVHAVLDVMGDFTDRLRSGEWTGATGKRINTVVNIGIGGSDLGPVMVYQALRHYADAGISARFVSNIDPADLTAKLSDLEPGTTLFIVASKTFSTLETLTNATAARRWLTDALGEAAVSKHFVAVSTNKRLVKDFGINTANMFGFWEWVGGRYSVDSAIGLSLMAVVGRESFADFLSGFHIVDQHFQNAPLESNAPVLL... | Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. | Q9CD75 |
Q6INS5 | RN168_XENLA | RING-type E3 ubiquitin transferase rnf168 | Xenopus | MTKEKTLPLPRSECICPICQEILLEPVTLPCKHTLCNPCFQMTVEKASLCCPFCRKRVSTWARLHSRTRTLVNTELWERIQKQYPKECQRRASGQESDDLADELASCPAPLLCQPGEIRQEYEAEVSKIEAERLAQEEAERKASEDYIQKLLAEEAAQDRLHSEAVQREMEEQLKIDEELARTLSVDLDVSNASCSSVSSVTSKKVVVSKSSKNVKNKQRVSGDIERFLTPRAVAVVGIDESMNSDSSECFIVFDEGEDEMPELSPQCPSTSLIQERGVELIMPYLSDCYKVESNTTSQQDRCSERSQVCNGTYSSCSDS... | E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with ube2n/ubc13 to amplify the rnf8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, lea... | Q6INS5 |
P40402 | SSUD_BACSU | FMNH2-dependent aliphatic sulfonate monooxygenase | Bacillus | MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTGVLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLLINVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNLLFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGRSVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQGDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQAL... | Catalyzes the desulfonation of aliphatic sulfonates. | P40402 |
O00469 | PLOD2_HUMAN | Lysyl hydroxylase 2 | Homo | MGGCTVKPQLLLLALVLHPWNPCLGADSEKPSSIPTDKLLVITVATKESDGFHRFMQSAKYFNYTVKVLGQGEEWRGGDGINSIGGGQKVRLMKEVMEHYADQDDLVVMFTECFDVIFAGGPEEVLKKFQKANHKVVFAADGILWPDKRLADKYPVVHIGKRYLNSGGFIGYAPYVNRIVQQWNLQDNDDDQLFYTKVYIDPLKREAINITLDHKCKIFQTLNGAVDEVVLKFENGKARAKNTFYETLPVAINGNGPTKILLNYFGNYVPNSWTQDNGCTLCEFDTVDLSAVDVHPNVSIGVFIEQPTPFLPRFLDILLT... | Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. | O00469 |
Q6ING2 | PUS10_XENLA | tRNA-uridine isomerase | Xenopus | MLLIEEKYRSVAQVLLSSGTCSRCVLRFCCVGSPANYRLPCKEVTYELQKYLSHGDPAEENDTPPSKKAKIEEDTSSNEHLGNCEDVNGSQVVRICPLCLGILQQFCEPEFIEKVFVKINSAVYELKDFVLSISLPAQLSVREHSAWLQAKQEMGKHGHSLDKTDIVQLKEAYKWIIHPLLSDQLGIQADSKSLFEVAVVFTHPETDGDCHFLATVCRDCFKPTKNKQSVFTRMAVVKALEKIKEEDFRVQFPFPPSSPETTCEVVDIQCNHSPVFVAGRYNKYSRNLPQTPWIIDGERKIESSVEELITDHLVAAFRSS... | Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and ura... | Q6ING2 |
B8EA98 | IHFB_SHEB2 | Integration host factor subunit beta | Shewanella | MTKSELIEKLATRQSQLSAKEVEGAIKEMLEQMATTLESGDRIEIRGFGSFSLHYRAPRTGRNPKTGSSVDLEGKYVPHFKPGKELRERVDAVNV | This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. | B8EA98 |
Q5SJE2 | MTNA_THET8 | S-methyl-5-thioribose-1-phosphate isomerase | Thermus | MDRVLPFRFAEEEGVFWLLDQRRLPQEEVYVPVRTAREMAQAIRDMVVRGAPAIGVSAAFGMVLAHLAGEDLEEADRRLRASRPTAVNLFHALDRMRPFWGDLAGSLLEARRIWREVEETEAAISRHGAQVLWGQVLTHCNTGPLATGGYGTALGAIVEAYRLGRVRHVWVDETRPYLQGARLTAYELQKAGVPATLITDGMAGWLMARGAVDAVVVGVDRMALNGDFANKVGTYALAVLAHHHGIPFYAALPLSSVDPRLASGEGIPIEERSPEEVVAFRGVRIAPEGFPAYHPAFDVTPHRYLTGIITEKGVLYPPFA... | Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | Q5SJE2 |
A5CQM6 | METXA_CLAM3 | Homoserine transacetylase | Clavibacter | MTDAQIRSLIGRPPASGAWREGDPVADRLFASVGGVDLEAGGRIPSVRVAYETFGERDPDGGNAVLVLHALTGDSHLRGPAGPGQPTGGWWSGIVGPGLAIDTDRWFVVAPNMLGGCQGTTGPASLAPDGAEWGARFPFITIRDQVAVQAALADALGIDVWAAVVGGSMGGMQALEWGVGLPGRMRRLAILAAPAIASADQIALNSVQAEAIRMDPAYRDGDYFDAADGDGPHRGLALARRMALLNYRSPDELNQRFSRSWQSGISPMGDEGRYAVESYLDFHGNKFTRRFDATSYIRLIDAMSSHDVGRDRGGVEAALA... | Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. | A5CQM6 |
A0QKT1 | GLMM_MYCA1 | Phosphoglucosamine mutase | Mycobacterium avium complex (MAC) | MGRLFGTDGVRGVANRELTAELALALGAAAARQLASGSAPGRRVAVIGRDPRASGEMLEAAVIAGLTSQGVDALRVGVLPTPAVAYLTGAYDADFGVMISASHNPMPDNGIKIFGPGGHKLDDGTEDRIEALVGDAGPRPVGAGIGRVIDAEDAADRYLRHLSKASTLRLDGLTVVVDCAHGAASSVAPRAYRAAGARVIAINADPNGLNINDNCGSTHLDSLRAAVVAHRADLGLAHDGDADRCLAVDADGNLVDGDHIMVVLALAMREAGELASDTLVTTVMSNLGLHLAMRSAGITVRTTGVGDRYVVEELRAGDYS... | Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. | A0QKT1 |
P0DPD7 | EFMT4_HUMAN | EEF1A lysine methyltransferase 4 | Homo | MASPGAGRAPPELPERNCGYREVEYWDQRYQGAADSAPYDWFGDFSSFRALLEPELRPEDRILVLGCGNSALSYELFLGGFPNVTSVDYSSVVVAAMQARHAHVPQLRWETMDVRKLDFPSASFDVVLEKGTLDALLAGERDPWTVSSEGVHTVDQVLSEVSRVLVPGGRFISMTSAAPHFRTRHYAQAYYGWSLRHATYGSGFHFHLYLMHKGGKLSVAQLALGAQILSPPRPPTSPCFLQDSDHEDFLSAIQL | Protein-lysine methyltransferase that efficiently catalyzes three successive methylations on 'Lys-36' in eukaryotic translation elongation factor 1 alpha (EEF1A1 or EEF1A2). | P0DPD7 |
Q9RXK7 | RS12_DEIRA | 30S ribosomal protein S12 | Deinococcus | MPTTQQLLRKGRKVLQKKSKVPALKGSPFRRGVCTVVKTTTPKKPNSALRKIARVRLSSGFEVTAYIPGEGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGSLDTQGVKDRNKSRSKYGTKKPKAGAAAAKK | Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The com... | Q9RXK7 |
P53695 | EXO1_SCHPO | Exodeoxyribonuclease I | Schizosaccharomyces | MGIKGLLGLLKPMQKSSHVEEFSGKTLGVDGYVWLHKAVFTCAHELAFNKETDKYLKYAIHQALMLQYYGVKPLIVFDGGPLPCKASTEQKRKERRQEAFELGKKLWDEGKKSQAIMQFSRCVDVTPEMAWKLIIALREHGIESIVAPYEADAQLVYLEKENIIDGIITEDSDMLVFGAQTVLFKMDGFGNCITIRRNDIANAQDLNLRLPIEKLRHMAIFSGCDYTDGVAGMGLKTALRYLQKYPEPRAAIRAMRLDKSLKVPVSFEKEFALADLAFRHQRVYCPKDKTLVHLSPPERELSVHEDAFIGSFFDNQLAID... | 5'->3' double-stranded DNA exonuclease that could act in a pathway that corrects mismatched base pairs. | P53695 |
Q4ZU60 | GCH4_PSEU2 | GTP cyclohydrolase FolE2 | Pseudomonas syringae | MNKPLPDVALTEISPALVSLDWVGMQGVEVPIRLAEASIRHPVHAHVDLQVDLADPSVKGIHMSRLYRLLDGYAERQIVSPDTLAALLEAMVESHLDCHSSHARLTLSFNLLCRRPALITEGLSGWKSYPVKLDATWHAGRLCLDSSVDITYSSTCPCSAALSRQLLEEAFAARFGRQSFVDPMQVATWLRENASFATPHSQRSVATVQVRVAEQAAELGLMTLIDLVEQALGTPVQTAVKRADEQAFARLNGQNLMYVEDAARKVQQALEGRYAASSVSVRHFESLHPHDAAAQTSNYLS | Converts GTP to 7,8-dihydroneopterin triphosphate. | Q4ZU60 |
A6X0A5 | RL11_BRUA4 | 50S ribosomal protein L11 | Brucella | MAKKIAGQLKLQVAAGAANPSPPIGPALGQRGINIMEFCKAFNAASQEMEKGSPIPVVITYYQDKSFTFVMKTPPVTYFLKKAANLKSGSKTPGKASAGTISRDKVRTIAEAKMKDLNAADIEAAMRMIEGSARSMGLEVVG | Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | A6X0A5 |
Q5HRL5 | RL11_STAEQ | 50S ribosomal protein L11 | Staphylococcus | MAKKVEKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNARTQEQAGLIIPVEISVYEDRSFTFITKTPPAPVLLKKAAGVEKGSGEPNKTKVATVTKDQVREIAQTKMQDLNAADEEAAMRIIEGTARSMGITVQ | Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. | Q5HRL5 |
Q3U2S8 | HVCN1_MOUSE | Voltage sensor domain-only protein | Mus | MTSHDPKAVTRRTKVAPTKRMSRFLKHFTVVGDDYHTWNVNYKKWENEEEEEEPAPTSAEGEGNAEGPDAEAGSASTPRQSLDFRSRLRKLFSSHRFQVIIICLVVLDALLVLAELLLDLKIIEPDEQDYAVTAFHYMSFAILVFFMLEIFFKIFVFRLEFFHHKFEILDAFVVVVSFVLDLVLLFKSHHFEALGLLILLRLWRVARIINGIIISVKTRSERQILRLKQINIQLATKIQHLEFSCSEKEQEIERLNKLLKQNGLLGDVN | Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis. | Q3U2S8 |
B8HD07 | RS10_PSECP | 30S ribosomal protein S10 | Pseudarthrobacter | MAGQKIRIRLKSYDHEVIDVSARKIVETVTRAGATVVGPVPLPTEKNVYCVIRSPHKYKDSREHFEMRTHKRLIDIIDPTPKAVDSLMRLDLPADVNIEIKL | Involved in the binding of tRNA to the ribosomes. | B8HD07 |
Q4R7D9 | PSA7L_MACFA | Proteasome subunit alpha type-7-like | Macaca | MASRYDRAITVFSPDGHLFQVEYAQEAVKKGSTAVGIRGTNIVVLGVEKKSVAKLQDERTVRKICALDDHVCMAFAGLTADARVVINRARVECQSHKLTVEDPVTVEYITRFIATLKQKYTQSNGRRPFGISALIVGFDDDGIPRLYQTDPSGTYHAWKANAIGRSAKTVREFLEKNYTEDAIASDNEAIKLAIKALLEVVQSGGKNIELAIIRRNQPLKMFSAKEVELYVTEIEKEKEEAEKKKSKKSV | Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participate... | Q4R7D9 |
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