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AlphaFoldDB
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A6TGQ0
THIE_KLEP7
Thiamine-phosphate pyrophosphorylase
Klebsiella
MYQPDFPPVPFRLGLYPVVDSVAWIERLLEAGVRTLQLRIKDRRDSEVEDDVIAAIALGRRYHARLFINDYWQLAIKHQAYGVHLGQEDLETTDLSAIRQAGLRLGVSTHDDMEIDVALAARPSYIALGHVFPTQTKQMPSAPQGLEQLARHIQRLADYPTVAIGGISLEKAPGVLATGVGSIAVVSAITQAADWRAATDQLLALAGAGDE
Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).
A6TGQ0
Q5E8M1
FPG_ALIF1
DNA-(apurinic or apyrimidinic site) lyase MutM
Aliivibrio
MPELPEVETSRLGITPHLQGQTIKAIVVRTDKLRWPIPQELQKLVGQRVQSIRRRAKYLMIDTPKGSAIIHLGMSGSLRVLDEEVPSAKHDHVDLVLENGKVLRYNDPRKFGAWLYSEVGVAHQVLSKLGPEPLTNEFNSEYFAEKAKNKKTVVKQFIMNNAVVVGVGNIYASESLFMAQIHPKTSVGSLKASQITLLVAEIKKVLETAIKQGGTTLKDFNQVDGKPGYFAQELHVYGRAKKKCLLCSSIIQEEKIGQRNTFWCGHCQPFNK
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Q5E8M1
A3DJ13
TSAD_ACET2
tRNA threonylcarbamoyladenosine biosynthesis protein TsaD
Acetivibrio
MKDILILGIETSCDETSASVVKNGRQVLSNVISSQVALHQKYGGVVPEIASRKHVELIMPVIHQSLEEAGIKIEQVDAIGVTYGPGLVGALLVGLSAAKALAFALDKPLIGVHHIEGHIAANYIEHSLLEPPFVCLVASGGHSHIVYVQDYDKFEIMGKTRDDAAGEAFDKVARAVGLGYPGGPIIDKTAKLGNSKAIDFPRVHFGDQSLDFSFSGLKTAVLNYINSMEQKGEKYSVEDVCASFQAAVVDVLTDNLISAARIKGVKKVALAGGVAANSLLRSELVEKAKGLGLEVFYPKPVLCTDNAAMIACAAYYEFLRGHTSDVYLNAIPGLKLGER
Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.
A3DJ13
P23594
PP2A1_YEAST
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit
Saccharomyces
MDTDLDVPMQDAVTEQLTPTVSEDMDLNNNSSDNNAEEFSVDDLKPGSSGIADHKSSKPLELNNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPITALVDNKIFCLHGGLSPMIETIDQVRELNRIQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGFTFGQDVSEQFNHTNDLSLIARAHQLVMEGYAWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVRPGEPSVSRKTPDYFL
Exact function not known, phosphatase 2A performs an essential cellular function.
P23594
A0A0B4J240
TVA10_HUMAN
T cell receptor alpha variable 10
Homo
MKKHLTTFLVILWLYFYRGNGKNQVEQSPQSLIILEGKNCTLQCNYTVSPFSNLRWYKQDTGRGPVSLTIMTFSENTKSNGRYTATLDADTKQSSLHITASQLSDSASYICVVS
V region of the variable domain of T cell receptor (TR) alpha chain that participates in the antigen recognition . Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens . Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation . The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity .
A0A0B4J240
Q7SDH9
PSF1_NEUCR
DNA replication complex protein 1
Neurospora
MPMYGDLGNKLVQHAKRTQNLSHLPPYQTELVRAVAREIRDLDKDVASLLEPFQGSFDPSAEQATACTLLVNHLSMRRNKRCLLAYHRIRTDKLEELVWNGADILDLAGQTTGGPKGVTEGNEGGGTTSSLSPQEEDYFRQFGDLLALYKGQWTDIDLTGSLEPPRDLFIDVRVLKDAGEIQTEYGAINLTKNSQFYVRQGDVERLIVQGYLQKLG
The GINS complex plays an essential role in the initiation of DNA replication.
Q7SDH9
Q8PXV2
MFNB_METMA
4-(hydroxymethyl)-2-furancarboxaldehyde-phosphate synthase
Methanosarcina
MKLLVSPINSEEAIIASIGGADIVDVKNPKEGSLGANFPWVIREVKAVVNGRQPISATIGDFNYKPGTAALAALGAAVAGADYIKVGLYDIQTESQALELLTKITRAVKDYNPLKKVVASGYSDYKRINSISPLLLPAVAAEAGVDVVMVDTGVKDGKSTFEFMDEKELKEFTDLAHSYGLENAIAGSLKFEDIPLLERIGPDIIGVRGMVCGGDRSTSIRQELVEKLVAECQA
Catalyzes the formation of 4-(hydroxymethyl)-2-furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
Q8PXV2
P0DMM0
APOE_PHYMC
Apolipoprotein E
Physeter
MKVLWVALVITLLAGCQAEEVKPAPEPEVQLGQEWPGWQGSQPWEQALGRFWDYLRWVQTLSDQVQEELLSTQVIQELTVLMDETMKEVKAYREELEEQLGPVAQETQARVSKELQAAQARLASDMQDVRGRLAQYRSEVQAMMGHTTDELRDRLASHLRKLRKRLLRDAEDLQKRLAVYRAGALEGSERSVSAIRERLGPLVEQGRARAATVGTLASQTLRERAEAWHQKLRGRVEEMGTQARDHLEEMREQLDEVRAKVEEQGTQMRLQAEAFQARLKSWFEPLVEDMQRQWAGLVEKVQLAMATSSTSAPSENH
APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apoliproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles. Finally, APOE has also a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells.
P0DMM0
Q2W2L3
RPOA_MAGSA
Transcriptase subunit alpha
Magnetospirillum
MIQKNWQELIKPNKLHVEPGADPQRTAIVVAEPLERGFGMTLGNSLRRVLLSSLQGAAVTAIQIDGVLHEFSSIPGVREDVTDIILNIKTLGLRMHGEGPKRMHLRAVGPGEVTAGLIEVGHDIEIMDPELVLCTLDEGAKLNIEFTVETGKGYVPASQNRPEDSPIGLIPIDAIFSPVRKVAYKVENTRVGQVTDYDKLSMTVETNGAVTPDDAVALAARILQDQLQLFINFEEPTAVVEEEKKDELPFNKNLLRKVDELELSVRSANCLKNDNIIYIGDLVQKTEAEMLRTPNFGRKSLNEIKEVLAQMGLHLGMEIANWPPENIEELAKKLEEPY
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q2W2L3
Q128P8
PNCB_POLSJ
Nicotinate phosphoribosyltransferase
unclassified Polaromonas
MIITSLLDTDLYKFTMMQVVLHQFPGAEVEYRFKCRNAGAPGIGKLAPYVNEIREEIRGLCNLRFQDAELAYLKAMRFIKSDFVDFLGIFKLNEKYVSVTALPSGEIEVSIKGPWLHTILFEIPVLAIINEVYFRNTQKQPDLTEGRKRLDTKILELQADGLRELKIADYGTRRRFGKVWHEEVLRTLVTRLGTGMSGQLAGTSNVLFAMKLGLTPLGTMAHEYLQACQALGPRLRDSQVFGFESWAREYRGDLGIALSDVYGMSAFLRDFDMYFCKLFDGARHDSGDPFEWGERMLAHYVKNRVDPRTKTLIFSDALTVPRTIELYQQFRGRCQLAFGIGTNLTNDLGYEPLQIVIKMIRCNGQPVAKLSDTPSKNMCEDEKYLAYLRQVFEIG
Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.
Q128P8
B2IYE4
AROA_NOSP7
5-enolpyruvylshikimate-3-phosphate synthase
Nostoc
MDTIEIPALNRPVDATVEIPGSKSLTNRALLVAALAQGDSILENALFSEDSEYFAKCLEQLGIPITLNPHLAQIQLAGRGGEIPAKQADLFVGLSGTTARFISALVALGNGEYRLDGVPRMRERPMGDMLTVLETGGATVNFEGNSGFMPYTVYSQGFAGGNFCLKANQTSQQLSALLMIAPYAQQDTIFEVEGTLVSLSYIKMTCRLMADFGVEVIQIGDNQFQIKAGQRYQAQHYTVEPDASNASYFFAAAAVTGGRVRVKHLTKQSCQGDILWLNVLEQMGCQIKDSDDYTEVTGPKQLQGIDIDMNDISDLVQTLAAIAPFASSPITIRNVEHIRYKETDRIKAVVTELRRLGVQVEEFPDRLKIEPGPITPAEIETYHDHRMAMAFAVTGLKVPGIVIKDPGCTAKTFPDYFTRFFQMLEQ
Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
B2IYE4
J9VND4
PBP1_CRYNH
Poly(A)-binding protein-binding protein
Cryptococcus neoformans species complex
MSNERGRGRGGNRGGRGGMEGGSARRGAWRNGPPPAGSFPHSRGGSPALGQSPTPRMSINDHMHDLKIVQGERKGFQTDTDISRAAGPVERELQPWVPDGPSPPPQSNGGSGNADFETFGTTNNITWDQFETNERLFGAKTDFKEELYTTKLNKSGPDFHKREKEAERLAKQIMGQTSKNAHIAEERGQATDIRDEEEKYSGVSRAPNAYVPPSARRAMGQSSAALRPNPTFESNTNGSTPIPAKPASPAAHETAPPAPERRISDDPVGSKPEAPAMKVTGTTIRPITENAEVTVNGTNVTAETKPELSGVVNEWRQFVGTEREKVEAKKQSVLKSEKEKQLADFKKFQANFKVPLPLPKDILPILSKDEAKQKDIEAKATNALQAAKERKLSIAKDSPAKSPVILNSVKSDAPKPAPPKKIVMKIPEIPPFNPAKRKAPAVPVPESATQDIKLITSPAPSNGSLASQATKLNPTASTFVFKPRADAAPFKPGQPSVSPSIAPHQPSAGPSNTSASTAVPKGNAFFRDKLPEKTHINAREDFNPWKHGPVPRPNTVGTGWPYPGRKVGVPPPFMSPAAPPQMQMQFEDDPTSPSPHPAQPAMMPGMPPNYPPYGRFQPGMPPPYGVPGGMQNPMFSPGPHFSPHPGQPMGQPQHMMPGGPQPNMPMYFQNGMPQNPAFLPPQMQQFPHNPQRPGPGPGPGGPQMFYPNQMPPMPHQTPLQQHPVPFSGPSPAQPQFQHQHQHQHQHPHQQAPPPPPVQMSPAHSTPSGPGGVVQGGPQQNGQTQG
Involved in post-transcriptional regulation of gene expression by interactions with poly(A)-binding protein.
J9VND4
Q04J43
STKP_STRP2
Eukaryotic-type Ser/Thr protein kinase
Streptococcus
MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIGEEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVAFAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQNPLPSVIAENSSVPQALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYNRRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIKNPSQAVTEETYQPQAPKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANFEIGEEKTEASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSDVIAELKEKKVPDNLIKIEEEESNESEAGTVLKQSLPEGTTYDLSKATQIVLTVAKKATTIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAGTTYDVSKPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSVEGMVVEQSPRAGEKVDLNKTRVKISIYKPKTTSATP
Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Is involved in competence triggering, and is required for the expression of the central competence operon comCDE. StkP also plays an important role for bacterial survival in vivo. Identified target substrates that are specifically phosphorylated by StkP in vivo, mainly on threonine residues, are DivIVA, GlmM, PpaC, MapZ, KhpB (also called EloR/Jag, shown in strains R6 and Rx1) and StkP itself. Autophosphorylated StkP is a substrate for the cotranscribed protein phosphatase PhpP (shown in the avirulent strain Rx / Cp1015); PhpP and StkP appear to constitute a functional signaling couple in vivo.
Q04J43
B5ZXG4
DCTA_RHILW
C4-dicarboxylate transport protein
Rhizobium
MIAAPFDAVADSTGKKPFYSHLYVQVLAAIAAGILLGHFYPELGAQLKPLGDAFIKLVKMIIAPVIFLTVATGIAGMSDLKKVGRVAGKAMLYFLTFSTLALVIGMVVANVVQPGAGMNIDPASLDPTAVATYASKAHEQSIVGFLTNIIPTTIVGAFADGDILQVLFFSVLFGIALAMVGEKGEQVVNFLNALTAPVFKLVAILMKAAPIGAFGAMAFTIGKYGIGSIANLAMLIGTFYLTSLLFVLVVLGAVARYNGFSILALLRYIKEELLLVLGTSSSEAALPGLMNKMEKAGCKRSVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATGINLSWGDQILLLLVAMLSSKGAAGITGAGFITLAATLSVVPSVPVAGMALILGIDRFMSECRALTNLVGNAVATIVVARWENELDTAQLARALGGQAEESAPAGLQPAE
Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane.
B5ZXG4
Q03125
NRG1_YEAST
Zinc finger protein MSS1
Saccharomyces
MFYPYNYSNLNVSTMPALPGISAFDGMQDEENVEISPERKYQTLLPVLTNSHVVENELKHKLNKTAFDFRYQTKSENGSEKWEPKYLITPNLQTRSVSFDNSSVQYNSDSSEKSSLSQLTCNSSIIQQPENGIVSNDAYNKMANSRYSLKTRKQRTDPRNTLSDEEDLEQRRKYICKICARGFTTSGHLARHNRIHTGEKNHCCPYKGCTQRFSRHDNCLQHYRTHLKKGQ
Transcriptional repressor involved in regulation of glucose repression. Binds to UAS-1 in the STA1 promoter.
Q03125
Q9PE40
CLPX_XYLFA
ATP-dependent Clp protease ATP-binding subunit ClpX
Xylella
MSEDRPSRSGDGNKILYCSFCGKSQREVRKLIAGPSVFICDECVELCNDIIREELEEKSQSARSSLPKPKEILEVLDQYVIGQQRAKRTLAVAVYNHYKRIESRHKNDDIELAKSNILLVGPTGSGKTLLAETLARLLNVPFTIADATTLTEAGYVGEDVENIIQKLLQKCDYDVERAQHGIVYIDEIDKISRKSENPSITRDVSGEGVQQALLKLIEGTVASVPPQGGRKHPQQEFLQVDTKNILFICGGAFAGLDKVIQQRCTEAGGIGFGVKVKSSESKRDVGKVLAGVEPEDLIKFGLIPEFVGRLPVVATLDELDESALVKILTEPKNAITKQFKKLFEMENVELEFRQDALSAVARKALKRKTGARGLRTIVELVLLDTMYELPSQEGISKVVVDESVIENKSEPYLIYQTMPAKVASGE
ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
Q9PE40
Q0G9I9
CYB6_LIRTU
Cytochrome b6
Liriodendron
MSKVYDWFEERLEIQAIADDITSKYVPPHVNIFYCLGGITLTCFLVQVATGFAMTFYYRPTVTEAFASVQYIMTEANFGWLIRSVHRWSASMMVLMMILHVFRVYLTGGFKKPRELTWVTGVILAVLTASFGVTGYSLPRDQIGYWAVKIVTGVPEAIPVIGSPLVELLRGSASVGQSTLTRFYSLHTFVLPLLTAVFMLMHFPMIRKQGISGPL
Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions.
Q0G9I9
B4EC68
GUAA_BURCJ
Glutamine amidotransferase
Burkholderia cepacia complex
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDDFVREFAPKAVILSGSHASTYEDHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEMRAHGHTRLLDDIEDFTTAEGHGMLKVWMSHGDKVAELPPGFALMASTPSCPIAGMADEARGYYAVQFHPEVTHTVKGRQIIERFVLQIAGAKPDWIMKNHIEEAVAKIREQVGDEEVILGLSGGVDSSVAAALIHRAIGDQLTCVFVDHGLLRLNEGKMVLDMFEGRLHAKVVHVDASDQFLGHLAGVTDPEAKRKIIGREFVEVFQAEAKKLSKAKWLAQGTIYPDVVESGGTKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKREYADLLRRADAIFIEELRGTTATAQDAAAGLCGEADVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTYDYVTSLRAVQTTDFMTAHWAHLPYALLGRASNRIINEVRGINRVVYDISGKPPATIEWE
Catalyzes the synthesis of GMP from XMP.
B4EC68
Q7V8D2
SYT_PROMM
Threonyl-tRNA synthetase
Prochlorococcus
MPIIALPDGNKKKFDQPVTIMEVAESLGPGLAKAAIAGRVNGVLLDTCIPIEKDSEVNIITAKDQDGIETIRHSFAHLIGHAVKQLYPEAKMAIGPVIEDGFYYDIAYDHPFTPKDLEAIEARMKELVKLDYDVNVEIVSKEEARKEFEKRCEPYKIEIVDEIPENEIIKLYRHQEYTDMCRGPHVPNTRHLRTFKLMKVSGAYWRGDSNKTMLQRIYGTAWGSSKELKAYLKRLEEAEKRDHRRIAKQMSLFHTQEEAPGMIFWHAKGWAIYQVLEQYIRETLSLHDYQEIRTPQVVDRSLWEKSGHWEKFKDDMFTTTSENREYAIKPMNCPCHVQIFNQGLKSYRDLPIRLAEFGSCLRNEPSGSLHGLMRVRNFVQDDAHIFCTELQVQEEVSKFIDLVFEVYRSFGFDSVLIKLSTRPEKRVGSDEIWDKSEKALSDALDAKGLAWDLLPGEGAFYGPKIEFSLKDCLGRVWQCGTIQVDFSMPERLGASYVAEDSQRRTPVMLHRAILGSFERFIGILIEHYAGRLPIWLAPVQVVVMGITDRNAQACQDICKKLSALEYRTEVDLRNEKIGFKVREHTLQRVPFLIIIGDKEQQSGEVAVRTREGKDFGSMPLKGFTSLLDEAIALKGRSGVS
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
Q7V8D2
Q65LS8
HPR_BACLD
Protease production regulatory protein Hpr
Bacillus
MNRAEEPYTVKEALLFSQRMAQLSKALWKSIEKDWQQWIKPYDLNINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLEFSKKLNDKRNTYIQLTPKGEEVFLKILESYDPTRNAVLKGAQPLHQLYGKFPEIVEMMSIIRHIYGDDFMEIFEKSFSNIENEFTSEEGKMKKKQEAKEAGESIEVDKPLEPLKN
Negative regulator of protease production and sporulation.
Q65LS8
Q7U5C2
HEM3_PARMW
Pre-uroporphyrinogen synthase
Parasynechococcus marenigrum
MALTELRIASRRSQLAMVQTNWVKAELEKAHPGLTITVEAMATQGDKILDVALAKIGDKGLFTKELEAQMLVGRAEIAVHSLKDLPTNLPEGLMLGCITEREDPADALVVNAKNANHKLDTLPEGAVVGTSSLRRLAQLRHHYPHLSFKDVRGNVITRLEKLDSGDYDCLILAAAGLERLGFGNRIHQIIPGDISLHAVGQGALGIECVEDKPEVLEIIKVLEHTTTSRRCLAERAFLRELEGGCQVPIGVNSQINNEELTLTGMVASLDGKRLIRDEASGSAADPESIGIELAGKLKHQGAGAILKEIFDEVRPEA
Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
Q7U5C2
Q8RX56
UNC13_ARATH
Protein PROTON ATPASE TRANSLOCATION CONTROL 1
Arabidopsis
MEEENAVEILQRYRRDRRKLLDFMLAGSLIKKVIMPPGAVTLDDVDLDQVSVDYVINCAKKGGMLELAEAIRDYHDHIGLPYMNSVGTADEFFLATIPESSGSPPKRAPPPIPVLISSSSPMVTNPEWCESPSAPPLMRSESFDSPKAQELTVDDIDDFEDDDDLDEVGNFRISRRTANDAADLVPRLPSFATGITDDDLRETAFEILLACAGASGGLIVPSKEKKKEKSRSRLIKKLGRKSESVSQSQSSSGLVSLLEMMRGQMEISEAMDIRTRQGLLNALAGKVGKRMDSLLVPLELLCCVSRTEFSDKKAYLRWQKRQLNMLAEGLINNPVVGFGESGRKATDLKSLLLRIEESESLPSSAGEVQRAECLKSLREVAISLAERPARGDLTGEVCHWADGYHLNVRLYEKLLLCVFDILNDGKLTEEVEEILELLKSTWRVLGITETIHYTCYAWVLFRQYVITSERGLLRHAIQQLKKIPLKEQRGPQERLHLKTLKCRVDNEEISFLESFLSPIRSWADKQLGDYHLHFAEGSLVMEDTVTVAMITWRLLLEESDRAMHSNSSDREQIESYVLSSIKNTFTRMSLAIDRSDRNNEHHLALLAEETKKLMKKDSTIFMPILSQRHPQAIAFSASLIHKLYGNKLKPFLDGAEHLTEDAVSVFPAADSLEQYLLELMTSVCGEDTSGPYFKKLIPYEVESLSGTLVLRWINSQLGRILSWVERAYKQEHWDPISPQQRYGSSIVEVFRIVEETVDQFFALKVPMRSIELSALFRGIDNAFQVYTNHVMEKLASKDDLVPPVPVLTRYKKETAIKVFVKKELFDSKHLDERRSINIDVPATAMLCVQLNTLHYAVSQLSKLEDSMWLRWIAKKPREKIVIRKSMVEKSKSFNQKESFEGSRKDINAALDRICEFTGTKIIFCDLREPFIENLYKPNVSQSRLEGLIEALDTELGQLCSVIMEPLRDRIVTSLLQASLDGLLRVLLDGGASRVFHPSESKLLEEDVEVLKEFFISGGDGLPRGVVENQVARVRLVVKLHGYETRELIDDLRSRSSLEMQQGGKGKLGADTQTLVRVLCHRNDSEASQFLKKQYKIPRSHG
Controls the tethering of the proton ATPase AHA1 to the plasma membrane. Is essential for stomatal opening in response to low concentration of carbon dioxide and light.
Q8RX56
A3MYU1
SYT_ACTP2
Threonyl-tRNA synthetase
Actinobacillus
MPIITLPDGSQRQFDNPVSVMEVAQSIGAGLAKATIAGRVNGERRDACDIISEDSSLEIITAKDEDGLEIIRHSCAHLLGHAIKQLFPNVKMAIGPTIDNGFYYDVDLDRSLTQEDLDAIEKRMLELAKTNYDVVKKRVSWQEARDTFEKRGEPYKMAILDENIERTATPALYHHEEYIDMCRGPHVPNMRFCHHFKLQKVAGAYWRGDSKNKMLQRIYGTAWADKKQLAEYLTRLEEAAKRDHRRIGKALDLYHMQEEAPGLVFWHNDGWTIFRELETFVRTKLKEYDYQEVKGPFMMDRVLWERTGHWQNYADLMFTTQSENREYAIKPMNCPGHVQIFNQGLKSYRDLPIRMAEFGSCHRNEPSGSLHGLMRVRGFTQDDAHIFCTEDQIESEVTSCIRMVYDIYSTFGFSNIQVKLSTRPENRIGDDAMWDRAEDGLAKALTANGLSYEIQEGEGAFYGPKIEFALRDCLDREWQCGTIQLDFALPGRLDASYVAEDNGRRTPVMIHRAILGSIERFIGIITEEYAGFFPTWLAPTQAVVMNITDSQADYVQKVTKALSDAGIRVKSDLRNEKVGFKVREHTLRRVPYMLVCGDKEIEAGKVSVRTRKGADLGTFTIDEFVEILKNQVKARGLKLLGEE
Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
A3MYU1
A7GZK0
RL7_CAMC5
50S ribosomal protein L7/L12
Campylobacter
MAITKEDVLEFISNLSVLELSELVKEFEEKFGVSAAPVMVAGGAVAGGAAEAAEEKTEFNLVLVDSGDKKINVIKVVRALTGLGLKEAKDAVEGTPSVLKEGISKDEAEAAKKELEEAGAKVELK
Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.
A7GZK0
A1VYJ5
RPOC_CAMJJ
Transcriptase subunit beta'
Campylobacter
MSKFKVIEIKEDARPRDFEAFQLRLASPEKIKSWSYGEVKKPETINYRTLKPERDGLFCAKIFGPIRDYECLCGKYKKMRFKGVKCEKCGVEVANSKVRRSRMGHIELVTPVAHIWYVNSLPSRIGTLLGVKMKDLERVLYYEAYIVENPGDAFYDNESTKKVEYCDVLNEEQYQNLMQRYENSGFKARMGGEVVRDLLANLDLVALLNQLKEEMAATNSEAKKKTIIKRLKVVENFLNSNLNANTDSDEAVPNRPEWMMITNLPVLPPDLRPLVALDGGKFAVSDVNDLYRRVINRNTRLKKLMELDAPEIIIRNEKRMLQEAVDALFDNGRRANAVKGANKRPLKSLSEIIKGKQGRFRQNLLGKRVDFSGRSVIVVGPKLRMDQCGLPKKMALELFKPHLLAKLEEKGYATTVKQAKKMIENKTNEVWECLEEVVKGHPVMLNRAPTLHKLSIQAFHPVLVEGKAIQLHPLVCAAFNADFDGDQMAVHVPLSQEAIAECKVLMLSSMNILLPASGKSVTVPSQDMVLGIYYLSLEKAGAKGSHKICTGIDEVMMALESKCLDIHASIQTMVDGRKITTTAGRLIIKSILPDFVPENSWNKVLKKKDIAALVDYVYKQGGLEITASFLDRLKNLGFEYATKAGISISIADIIVPNDKQKAIDEAKKQVREIQNSYNLGLITSGERYNKIIDIWKSTNNVLSKEMMKLVEKDKEGFNSIYMMADSGARGSAAQISQLAAMRGLMTKPDGSIIETPIISNFREGLNVLEYFISTHGARKGLADTALKTANAGYLTRKLIDVAQNVKITIEDCGTHEGVEINEITADSSIIETLEERILGRVLAEDVIDPITNSVLFAEGTLMDEEKAKILGESGIKSVNIRTPITCKAKKGICAKCYGINLGEGKLVKPGEAVGIVSAQSIGEPGTQLTLRTFHSGGTASTDLQDRQVSAQKEGFIRFYNLKTYKNKEGKNIVANRRNAAILLVEPKIKTPFKGVINIENIHEDVIVSIKDKKQEVKYILRKYDLAKPNELAGVSGSIDGKLYLPYQSGMQVEENESIVEVIKEGWNVLNRIPFASEILVEDGEPVVQNIKAGEKGTLKFYILKGDGLDRVKNVKKGDIVKEKGFFVVIADENDREAKRHYIPRESKIEFNDSEKIDDANTIIASAPKKERKVIAEWDAYNNTIIAEIDGVVSFEDIEAGYSADEQIDEATGKRSLVINEYLPSGVRPTLVIAGKGDKAVRYQLEPKTVIFVHDGDKIAQADILAKTPKAAAKSKDITGGLPRVSELFEARKPKNAAVIAEIDGVVRFDKPLRSKERIIIQAEDGTSAEYLIDKSKHIQVRDGEFIHAGEKLTDGVVSSHDVLKILGEKALHYYLISEIQQVYRGQGVVISDKHIEVIVSQMLRQVKVVDSGHTKFIEGDLVSRRKFREENERIIRMGGEPAIAEPVLLGVTRAAIGSDSVISAASFQETTKVLTEASIAGKFDYLEDLKENVILGRMIPVGTGLYGEQNLKLKEQE
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
A1VYJ5
Q4ZLU8
RPIA_PSEU2
Phosphoriboisomerase A
Pseudomonas syringae
MTQDQLKQAVAQAAVDFILPKLDDKSIVGVGTGSTANCFIDALAKHKAAFDGAVASSQATAARLKAHGIPVYELNTVSDLEFYVDGADESDEHLNLIKGGGAALTREKIVAAVANTFICIADGSKLVPVLGAFPLPVEVIPMARSHVARQLVKLGGDPVYREGVLTDNGNIIIDVHNMSITNPVELEAQINAIVGVVTNGLFAARPADLLLLGTAEGVKTLTR
Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
Q4ZLU8
Q08920
NCBP2_YEAST
NCBP 20 kDa subunit
Saccharomyces
MSLEEFDEVKYDHSTKRLDTPSRYLLRKARRNPNGLQELRESMKSSTIYVGNLSFYTSEEQIYELFSKCGTIKRIIMGLDRFKFTPCGFCFIIYSCPDEALNALKYLSDTKLDEKTITIDLDPGFEDGRQFGRGKSGGQVSDELRFDFDASRGGFAIPFAERVGVPHSRFDNSSSQSNTNNYIPPPDAMGTFRPGFDEEREDDNYVPQ
Component of the CBC complex, which binds co-transcriptionally to the cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation. Together with NPL3, the CBC complex is required for export of mRNAs out of the nucleus. The CBC complex is also involved in nuclear mRNA degradation, probably by directing the mRNAs to the sites of degradation. Affects replication of the positive-strand RNA virus BMV.
Q08920
Q8KA50
PT1_BUCAP
Phosphotransferase system, enzyme I
Buchnera
MISGILASPGIAFGNVLLLKKEEIVINRQNISTENIKTEINKFFNGRKKSVKQLTEIKIATGEKFGKKKEGIFEGHIMLLEDEELEKEIINLITEKKISAAEATKFIIEGQAKALEKIKDEYLKNRAIDVRDIGSRLLKNILNISIVDLNNIKNQVILISKDLTPSETAQINLKYILGFITDLGGPTSHTSIMARSLEIPAIVGTVNITKKVKNNDFIILDSLNNEIIINPSDQIINEKKQVERKYFFKKENLKKLRNLYATTTDGHNIKIGSNIGNIQDIYSAKKNGAECIGLYRTEFLFMGRNALPTENEQFQAYKEIAESMENKPVIIRTMDIGGDKDLPYMNLPKEENPFLGWRAIRISMDRKEILHAQLRAILRASAFGKIYILFPMIISVEEIRTLKIEVHKLQIQLKKEHLVFDENIKIGIMIETPASAIIADHLIKEVDFFSIGTNDLTQYTLAVDRGNDLISHLYNPISPSVIQLIKQVIDISHLHGKWTGMCGELAGDERVTTLLLGMGLDEFSMSSTSIPKIKEIIRKTSFSKSQELAKKVLKAATTKEILDLLNKFII
General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
Q8KA50
Q0HS04
APAH_SHESR
Diadenosine tetraphosphatase
Shewanella
MAHYFVGDVQGCFAELKRLLAEVDFNPSRDELWAVGDLVARGPDSLATLRYFQSLGDAGKTVLGNHDLHLLALHGKLKRDKPSDNLAPLLNAPDIASLIDWLRQQPLMRELPEHKVIMTHAGVPPQWSLDVLRQESQLVSQALKQSDYLEALISQMYSDTAERWDPSAIGLNRLRFCINALTRMRYLYVDGHLDFDCKQPPEDCSNPQLRPWFEFTSALRQSHTLVFGHWAALMGKVNDPKLKALDTGCCWGEYLTLWHLEKDQKITQKKLKKG
Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.
Q0HS04
A1W581
DER_ACISJ
GTP-binding protein EngA
unclassified Acidovorax
MKPVIALVGRPNVGKSTLFNRLTKSRDAIVADFAGLTRDRHYGNGRQGKHEYIVIDTGGFEPDASSGIYREMARQTQQAVAEADVVVFVVDVRGGLSAQDHDIANYLRRLGKPCVLAGNKAEGMQDSMHLAEFYELGLGEVHPVSAAHGQGVRSLVDLALKPLALPEIEEEDAAAEKNVIRLAVAGRPNVGKSTLINTWLGEERLVAFDMPGTTRDAISVPFERNGQKFELIDTAGLRRKGKVFEAIEKFSVVKTLQAIESANVVLLLLDATQGVTDQDAHIAGYILESGRAVVIAVNKWDAVDDYGRQQLERSIETCLSFLKFAPLHFISAKKRQGIGPLWSSIIQAYKSANRKMPTPVLTRLLQEAVQFQSPKRSGMFRPKMRYAHQGGMNPPVIVIHGNSLEHVTDAYKRFLEARFRKEFDLVGTPLRIEMKTSSNPYTDKQNS
GTPase that plays an essential role in the late steps of ribosome biogenesis.
A1W581
Q0RDP7
RNH2_FRAAA
Ribonuclease HII
Frankia
MRPRGVVIRRDAGLFGYERALVRCGLGPVAGVDEAGRGACAGPLVVAAVVLGPDGRRRLSPRLADSKLLTEQVREGLFDEVLRAAADWSAVVIPAAEIDRTGVHVANITGMRRAVARLGHRPGYVLTDGFAVAGFGTESLAVVKGDRVAACIAAASIVAKVTRDRIMRALHTRYAEYDFAQHKGYVTAAHAAALARYGPCDEHRKSYVNVAAHAVPTREARSLRLEDRVLATSLHGVTETA
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Q0RDP7
Q8RLX0
SOXA_CHLTI
Thiosulfate-oxidizing multienzyme system protein SoxA
Chlorobaculum
MKKTIQRGLFTGALVLLTAMTSKPAHAAVNYQALVDADVKKFQGYFLKEFPGVKLEDFGDGVYALDEDSRKQWKEMEEFPPYELDVEAGKALFNKPFANGKSLGSCFSNGGAVRGMYPYFDEKRKEVITLEMAINECRVANGEKPYAPKKGDIARVSAYIASISRGQKIDVKVKSKAAYDAYMKGKEMFYAKRGQLNMSCSGCHMEYSGRHLRAEIISPALGHTTHFPVFRSKWGEIGTLHRRYAGCNENIGAKPFPAQSKEYRDLEFFQTVMSNGLKFNGPASRK
C-type monoheme cytochrome, which is part of the SoxAX cytochrome complex involved in sulfur oxidation. The SoxAX complex catalyzes the formation of a heterodisulfide bond between the conserved cysteine residue on a sulfur carrier SoxYZ complex subunit SoxY and thiosulfate or other inorganic sulfur substrates. This leads to the liberation of two electrons, which may be transferred from the SoxAX complex to another cytochrome c and which then may be used for reductive CO(2) fixation.
Q8RLX0
B0KSC5
ISPF_PSEPG
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Pseudomonas
MRIGHGYDVHRFCDGDFITLGGVRIPHKYGLLAHSDGDVLLHALSDALLGAAALGDIGKHFPDTDPQFKGADSRALLRHVVGIVRAKGWKVGNVDATIVAQAPKMAPHIETMRQLIAEDLQVELDQVNVKATTTEKLGFTGREEGIAVHSVALLLPA
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
B0KSC5
Q7UFU6
QUEC_RHOBA
Queuosine biosynthesis protein QueC
Rhodopirellula
MERRLVNSTSQSKTESAQQDAGKAVVLLSGGLDSATCVAIARDQGFEVHAISFRYGQRHDGELDRAAKQASLMGVVSHRVIDIDLAQLGGSALVDSSIAVPKSDHVDKIAGDIPVTYVPARNTIFLSYALAVAETLGSRDIFIGVNALDYSGYPDCRPEFIDAFQTMARLATKAGVEDEHSLTIHTPLLHWTKAEIIQRGIELGVDYSQTLSCYDPQGSSDEMRPCGQCDACLLRAKGFAENEIADPAIG
Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
Q7UFU6
C1DKZ4
LFTR_AZOVD
Phenyalanyltransferase
Azotobacter
MLTCLQRDSLSFPPLERALHQPNGLLAVGGDLSAERLIQAYRHGCFPWYQAGQPILWWSPDPRTVLFPRELHVSRSLRKVLRQERFQVSFDRDFAAVIQACAGPRDYADGTWITPEMRKAYQELHHRGIAHSVEVWQNGVLVGGLYGLAIGQLFFGESMFSHADNASKVGFATLVERLERWGFVLIDCQMPTQHLQSLGARSIPRTEFSDYLMHHLDLPSTADWIA
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.
C1DKZ4
B2ADA5
GH6D_PODAN
Probable exoglucanase GH6D
Podospora anserina
MRAVYAILAGLLATGSASPLEARQSGNPFVGRSLFVNPKYSESLERTRQAFLSRGDQTNAAKVQYVQNKVGTFVWISNIFLLRDIDDAIRNARAAQSRGEKPIVGLVLYNLPDRDCSAGHSSGELSLDQNGLNRYRTEYVQPFAQKLKAASDLQFAVILEPDAIGNMVTGTTAFCRNARGPQQDGIAYAIQQLQASNIHLYLDVANGGWLGWADNLKPTTILQKAGSNARIRGYSSNVSNYNPYSTNNPPPYTAGSPSADESRYATSLGNALRERGLPTNFIIDQGRVALDGARKEWGEWCNVSPAGFGQPFTTNTNNPNVDAILWVKPGGESDGTCGMSGAPQAGAWFDAYAQMLTTNAHPEIRADGGGGGSPAPGPSSTAVAPSPSATPGGNCAARWAQCGGQGWTGPTCCAQGTCQASNQWYSQCL
Probable exoglucanase that may play an important function in biomass degradation by catalyzing the hydrolysis of cellulose.
B2ADA5
A9AES0
MINC_BURM1
Probable septum site-determining protein MinC
Burkholderia cepacia complex
MSLKKSPFFELRSGSVDTLLFTVKTTDLDALRAELVKRFEATPEFFADDVVAIDVRRLADGERVALADIRQMLSDVRMRPVGVVALATQGWATEAGLPLLEARDRRAPAAKAADEAEPVAAPAVEAAAAPAAEPTPEPGAASQPAGVQTLVIDRPLRSGQQIYAKGDLVVLAPVSHGAEIIAEGNIHIYAPLRGRALAGVHGNHDARIFCTCLEPELISIAGIYRTTENPLPADVLGKSVQIRLEEEKLMIEPLRLT
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
A9AES0
B2JA13
PSBH_NOSP7
Photosystem II reaction center protein H
Nostoc
MAQRTRLGDILKPLNSEYGKVAPGWGTTPVMAVFMALFFVFLLIILQLYNRSLLVQDVLVDWRSLGR
One of the components of the core complex of photosystem II (PSII), required for its stability and/or assembly. PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation.
B2JA13
B1JX26
UREG_BURCC
Urease accessory protein UreG
Burkholderia cepacia complex
MNAPAPSSVRRTKKLPPLRVGIGGPVGSGKTTLLEMLCKAMRDRYDLVAITNDIYTKEDQRLLTVAGALPEERIMGVETGGCPHTAIREDASINLEAVDRMLARFPDADIVFIESGGDNLAATFSPELSDLTIYVIDVAGGEKIPRKGGPGITKSDLLVINKTDLAPLVGANLDVMASDTRKMRGERPYVMTNLKALDGVADVIAFIEKKGLLTV
Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.
B1JX26
B4SJX6
MURC_STRM5
UDP-N-acetylmuramoyl-L-alanine synthetase
Stenotrophomonas maltophilia group
MIRRLHDTNDLVRAFPRVHFVGIGGTGMSGIAEVMLTLGYEVSGSDNADNVATRRLASLGARIMRGHSAANVLGTDCVVVSSAIREDNPELMEARSQRIPIMPRAAMLAELMRFRRGIAVAGTHGKTTTTSLTAAVLSEGGLDPTFVIGGQLLAAGANAKLGGGQWLVAEADESDGSFLRLNPLMSIITNIDADHLENYGNDFARVQAAFAEFLQRLPFYGLAVLCIDDPEVAALAAKTPRHVMSYGMSPQADVRAENVVQEGSRMRFTLRLPQGTSQEVVLALPGKHNVLNALAAAAVGWQLGVAPDAIARALEGFAGVGRRFNDLGEVTTASGAKVRIIDDYGHHPSELEAVFAAARGGWADKRLVVAFQPHRYSRTRDQFDKFAAVLSSVDALVLSEVYPAGEEPIAGADSHALARAIRARGRSEPVVVGKAAELASVLPDVLQDGDLLLMMGAGDIGAVATHIAVEGFKGEGEA
Cell wall formation.
B4SJX6
Q8DD43
TRMA_VIBVU
tmRNA (uracil(341)-C(5))-methyltransferase
Vibrio
MATLDVNPQRYQQQLAEKVQRLTDMFAPYQAPELEVFESPDQHYRMRAEFRVWHEGEEMYYIMFNQETREKYRVDQFPAASRLINDLMPLLIDAMKDNESLRRKLFQVDFLSTLSGEILVSLLYHRQLDDAWIENAKALKQRLNDEGFNLNLIGRARKMKIVLDRDYVVEKLDVNGKPYTYQQVENSFTQPNGKVAEKMLEWAVDCTQESQGDLLELYCGNGNFSLALAQNFERVLATELAKPSVESAQYNIAANKIENVQIIRMSAEEFTEAMEGKREFRRLKDNGIDLKSYNCNTIFVDPPRSGMDVDTCKMVQGYERILYISCNPETLKENLDILSETHHITRFALFDQFPYTHHMEAGVMLERKA
Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA).
Q8DD43
A7Z4C5
COAD_BACVZ
Pantetheine-phosphate adenylyltransferase
Bacillus amyloliquefaciens group
MASIAVCPGSFDPVTYGHLDIIRRGANVFEQVYVCVLNNSSKQPLFTVEERCELLREVTKDIPNVTVETSQGLLIDYAKKKRAKAIIRGLRAVSDFEYEMQGTSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVAKYNGPVSEFVPPEVEQALMQKFKG
Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.
A7Z4C5
Q47BG9
AMPA_DECAR
Leucyl aminopeptidase
Dechloromonas
MEFSIKSGSPEKQRSACVVVGVFESRKMTLPAELLDKASGGYISDIVRRGDMEGKAGSTLLLHSVPSTLCDRILLVGLGKEKDFREKEFASAIRTAVKVLNETGAFDASIFLTELPVRKRSIAWRVRQTAMIALDATYKFDQFKSKKEEIRRPLRKLTISVERRNELAPAEEALAQGLAIAEGMAMAKTLGNLPPNICHPTYLAEQAQAMAEEFKLGCEILDRAEMEKLGMHSLLSVARGSHQPPKLIVLTYKGARASEKPIVLVGKGVTFDTGGISLKPGAEMDEMKYDMCGAASVLGTMQAVARMALPINLTVVVPATENMPGGNATRPGDIVTSMSGQTIEILNTDAEGRLILCDALTYAERFEPDTVIDVATLTGACVVALGSIATGLFANKDALARDLLDAGEDANDRGWHMPLWDDYQELLKSPFADMANIGGRWGGAISAACFLSRFTKKFDWAHLDIAGTAWKSGADKGATGRPVPMLAYYLLQRAGKLN
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Q47BG9
O18728
FSCN2_BOVIN
Retinal fascin
Bos
MPTNGLHQVLKIQFGLVNDTDRYLTAESFGFKVNASAPSLKRKQMWVLEPDPGEGTAVLFRSSHLGRYLSAEEDGRVACEAERPGRDCRFLVLPQPDGRWVLQSEPHGRFFGGTEDQLSCFATAITPAELWTVHLAIHPQAHLLSVSRRRYAHLCPQEDEIAADSNTPWGVDALVTLIFQNRQYCLKSCDSRYLRSDGRLVWEPEARARYTLEFKAGKLAFKDCDGHYLAPVGPAGTLRAGRNTRPGKDELFDLEESHPQVVLVAANHRYVSVRQGVNVSANQDEELDHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSENTMFEMEWRGRRVALKASNGRYVCMKKNGQLAAISDFVGEDEEFTLKLINRPILVLRGLDGFVCHRRGSNQLDTNRSVYDVFHLSFSDGAYQIRGRGGGFWHTGSHGSVCSDGERAEDFLFEFRERGRLAIRARSGKYLRGGASGLLRADADAPAGVALWEY
Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.
O18728
P0CW43
FWDC_METMP
Tungsten-containing formylmethanofuran dehydrogenase II subunit C
Methanococcus
MNELILNLKGDVSVPVEMDKILPEKIQEMSLEEISGIELIQGNKTAKVSEIFDVELKESDVAKVTINNCCKKVKRIGEKMTSGEIVVNGDAGMYIGVEMKGGKITVNGDAESWVGQNLKGGEIIINGNAENYVGSAYRGDWRGMSGGKITITGNAGSELGEYLKGGTIVIKGNTKIMPGIHQNGGMIIIEGDIEGRAGGEMMKGAIVVYGKILEPLPSFKFEGIVEDPLVKLSKKDAGTQLKGTFIKFSGDYVNTKPKGQLYAAIENNKNLI
Catalyzes the reversible oxidation of CO(2) and methanofuran (MFR) to N-formylmethanofuran (CHO-MFR). This enzyme is oxygen-labile.
P0CW43
C5BB97
HLDD_EDWI9
ADP-L-glycero-beta-D-manno-heptose-6-epimerase
Edwardsiella
MIIVTGGAGMIGSNIVKALNDKGYTDILVVDNLKDGTKFVNLVDLDITDYMDKEDFIAGIVAGDDFGDIDAVFHEGACSSTTEWDGKYVMDNNYQYSKELLHFCLERQIPFLYASSAATYGMTDKFVEDRHYEGPLNVYGYSKFLFDQYVRRILPHAKSQICGFRYFNVYGPREGHKGGMASVAFHLNTQINNGEQPKLFEGSENFRRDFIYVGDVADVNLWFWENGVSGIFNCGTGNAESFQAVADAVVAYHQKGSVTYIPFPDKLKGRYQAFTQADTTQLRAAGYSRPFKTVAQGVREYMEWLNRKP
Catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
C5BB97
C5B7R2
LEUC_EDWI9
Isopropylmalate isomerase
Edwardsiella
MGKTLYQKLYDAHIVHQTPGETPLLYIDRHLVHEVTSPQAFDGLRAQRRRVRRPEHTFATMDHNVSTQSRDIHACGEMARVQMETLMANCREFGVQLYDLHHPHQGIVHVIGPEQGMTLPGSTIVCGDSHTATHGAFGALAFGIGTSEVEHVLATQTLKQDRARTMQVVIQGRCAEGISAKDIVLAVIGHLGHAGGTGYVVEFCGPAVEALSMEGRMTLCNMAIELGAKAGLIAPDETTFAYLQGRPFAPQGAQWQQAVDHWRTLRSDADARYDRTVTLQADDIAPQVTWGTNPGQVIAIDTPIPSPASLSDPIARASAHKALAYMDLQPGTRMSDVAIDRVFIGSCTNSRIEDLRAAAAVARGRRVAPGVQAMVVPGSGPVKAQAEAEGLDKIFTEAGFEWRLPGCSMCLAMNNDRLGSGERCASTSNRNFEGRQGRGGRTHLVSPAMAAAAAVCGHFADIRQFQEPAHD
Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.
C5B7R2
C0RFV3
DCUP_BRUMB
Uroporphyrinogen decarboxylase
Brucella
MNLKVLKVIDGETVFPPPIWMMRQAGRYLPEYRETRKKAGSFLDLCYSPDLAVEVTLQPIRRFGFDAAILFSDILVVPHALGRDLRFEEGKGPLMTPIDADEIFWLETEGVAKRLEPVYETVRLVREQLPDETTLLGFCGAPWTVATYMIAGHGTPDQAPARLFAYRFPEAFEKLLNDLADVSAEYLIEQLGAGADAVQIFDSWSGVLDEDCFERFCIRPVARIVQKVRAVYPQARIIGFPKGAGMLYAGYREKTGVDMLGLDWSVPLSFAALLQEEGAVQGNLDPLRVVAGGNALDEGVDAILERMGQGPLVFNLGHGITPQAPIENVQRMIDRVRGGKS
Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
C0RFV3
Q0STR1
HFQ_CLOPS
RNA-binding protein Hfq
Clostridium
MNKSINNLQDIFLNNARKERIPVTIFLVNGVQLKGIVKGFDSFTVVLDSDGKQQLVYKHAISTVSPAKPILFNSAQVFDN
RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.
Q0STR1
P33376
PHLD_BACCE
Phosphatidylcholine cholinephosphohydrolase
Bacillus cereus group
MKKKVLALGAAITLVAPLQSVAFAHENDGGQRFGVIPRWSAEDKHKEGVNSHLWIVNRAIDIMSRNTTLVKQDRVALLNEWRTELENGIYAADYENPYYDNSTFASHFYDPDNGKTYIPYAKQAKETGAKYFKLAGESYKNKDMKQAFFYLGLSLHYLGDVNQPMHAANFTNLSYPQGFHSKYENFVDTIKDNYKVTDGNGYWNWKGTNPEDWIHGAAVVAKQDYAGIVNDNTKDWFVRAAVSQEYADKWRAEVTPMTGKRLMDAQRVTAGYIQLWFDTYGNR
Required, with sphingomyelinase, to effect target cell lysis (hemolysis).
P33376
B1LM67
BIOF_ECOSM
8-amino-7-ketopelargonate synthase
Escherichia
MSWQEKINAALDARRAADALRRRYPVAQGAGRWLVADDRHYLNFSSNDYLGLSHHPQIIRAWKLSAEQFGVGSGGSGHVSGYSVAHQALEEELAEWLGYSRALLFISGFAANQAVITAMMAKEDRIVADRLSHASLLEAASLSPSPLRRFAHNDVTHLARLLASPCPGQQLVVTEGVFSMDGDSAPLEEIQQVTQQHDGWLMVDDAHGTGVIGEQGRGSCWLQKVKPELLVVTFGKGFGVSGAAVLCSNTVADYLLQFARHLIYSTSMPPAQAQALRASLAVIRSDEGDARREKLAALITRFRAGVQDLPFTLADSWSAIQPLIVGDNSRALQLAEKLRQQGCWVTAIRPPTVPAGTARLRLTLTAAHEMQDIDRLLEVLHDNG
Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
B1LM67
A4XYC6
G6PI_PSEMY
Phosphohexose isomerase
Pseudomonas
MAYYQQPHDITRLPAWQALQQHRAEMAGFSMREAFAGDPRRFQRFSLDSCGLLLDYSKNLITEKSLELLIQLAEQADLHEAIAALYNGERVNASEGRAALHTALRSPIGRRLLVDGNDIIPEVHRVLNQVTELVSRIHSGLWRGYSEKPIKEVVNIGIGGSFLGPQLVSEALRPFTQRGVRCHYLANIDGSEFRELTARLDPETTLFIVSSKSFGTLETLKNTLAARDWYLAMGGPEEQLHRHFIAVTSNRKAAIEFGIGEENIFPMWDWVGGRYSLWSAIGLPIALAIGVSNFKELLAGAYAMDEHFTQAPLAENMPVLMALLGVWYTNFWGAQSHAILPYDHYLRNFTKHLQQLDMESNGKSVRQDGTPLDIATGPIIWGGVGCNGQHAYHQLLHQGRLLVPADFIVPVNSYNPLSDHHQWLFANCLSQAQALMQGKTREEAEVELRAKGLSEDEVQRLAPHKVIPGNRPSNILVMNRIAPFNLGALVALYEHKVFVQSAIWGINAFDQWGVELGKEMGKEVYQRLTGASGEPASDASTQGLIEHFRSQHRG
Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.
A4XYC6
Q1RIX0
IF2_RICBR
Translation initiation factor IF-2
belli group
MTDNQENKPKKLTLSNTKLSLNKSFDSLASTQSFVNAKSKTLVEVRKSYSGSTTTLSLNKEKGSLETGSSSGSEEFNRRLSILKKAAEQSKLNDNSQISTLSKLASINQSIASQEDPIEVEQEESSDTNKVKEEPKIEEVKDIEESTLQTPKKKEDIFVKSPLVGTRTRYGIESEKTVDKVTENKVIAPKPKVEESRKFKKTDLFNMVGDDENDNRNRTRSLASIKRAREKEKRKSLVQAPEKVYREITLPEVIGVGDFANAMSERVSDVIKELMKLGILANASQTIDADTAELVATHLGHAVKRVQESDVENILITNDKEEDLRSRAPVVTVMGHVDHGKTSLLDALKSTDVASGETGGITQHIGAYRVTLADGRAITFIDTPGHEAFSEMRSRGAGVTDIVIIVVAADDGIKPQTVEAINHAKAANVPIIVAINKIDKPDIDIERVKNELYMYEIIGEEAGGDVMVIPISALKKINLDKLEEAILLIAEMQNLKASPFGSASGVVIESKIEKGRGALTTMLVQRGTLKSGDIIIAGTAYGKVKKMTNDKGIEVLEATPSVPIEIQGLSHVPHAGDMFNVVQTEKQAKDIAEYRERVAKEKKISIAPRSSLEDLFLKASGSSKIKELPLIIKGDVHGSVEAIAGSLLKLPNDEVKLRILHSGVGPITESDVSLAHASSAIIVGFNVRAGANAKTAAEKEKVEIRYYSIIYDLLDDVKAIMSGMLDPIIREQYIGSVEIRQIFNITKIGKIAGSYVTRGIIKKGAGVRLLRDNIVIHEGKLKTLKRFKEEVKEVREGYECGIAFENYEDIREGDTVEVFELIQEKKQL
One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.
Q1RIX0
B9LMX0
AROC_HALLT
5-enolpyruvylshikimate-3-phosphate phospholyase
Halorubrum
MNGNRFGRLFQVTTYGESHGEAMGVTVSGVPAGVELDEEAIQAQLDRRKPGQSMITTSRGEPDEVVVNSGVQDGYTTGTPIGMVIQNKDARSGKYEPYVTAPRPSHGDYTYSAKFGTRNWGGGGRSSARETVNWVAAGAVAEQVLDASEYDVEIKAHVNQIGDVEADDVSFEQILDHSEENDVRCADPEAAAEMQELIERYQEAGDSIGGSIYFECRGVPRGLGAPRFDGFPSRLGQAMFSIPATTGVEFGLGKDAVNVTGSERNEDWTFDDGESFDHVESEEGDPVPVGNDHGGLQGGITTGEPIYGEATWHAPTSIPKKQRSADWETGEEKDVQVVGRHDPVLPPRAVPVVEAMLYCTVLDFMLLAGRINPDRVDGNPGQYDTDYHPSSPDND
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
B9LMX0
Q4WKW9
FGNA_ASPFU
Partially reducing polyketide synthase fngA
Aspergillus subgen. Fumigati
MSFPQVDVPSLPVGSASTQDTSPVSGPFNSSDSDHDIVNGGQANGSPFTEPIAICGLGLRLPGGIRDGDSFWDLLVNGRDARMPIPASRYNISGFDGSLDGRDPIKTTHGYFLDEDLSSLDASFFSMTKTELEKCDPQQRQLLEVTRECLEDAGETDYRGRNVGCYIGNFGHDWMEISLREPQHSRSYNVLGYSDMILANRVSYEYDLRGPSVVIKTACSASLVALHEACRALQARDIPSAIVGGTSLILAPTLTSNFFGEGILSPEASCKTFDESADGFARAEGVTAIYVKRLDDALRDGNPIRAVIRGTGTNSDGKSMGIMSPSAEAHEALMRQVYDQAGLSPRETAFVEEKRRLSNASKCHGTGTATGDPIEATAVGNVFSERGVYIGSVKPNVGHSEGCSGITSLIKAVLALEHKTIPPNIKFRNPNPKIPFVEKKLVVPIQPTPFPLDKAERISVNSFSIGGSNAHIDAYKSYARDHPDAISDIAYTLAVRRERLPHRAFAIWQNGELQTSSLSKASAVPPAITMIFSGQGAQWAEMGKKLIETEASFRHDLASMDSILQSLRKPPCWSILEELQKPAEDSQINRAEMAQPLCTALQVALFHQLKRLGIKPTAVVGHSSGEIAAAYAAGYITLEYALAVAYYRGYITKNADRSRGAMAAVRLSATEVLPFLRTGVCIACENSPSSTTISGDKEALKEILARLKEEKPDVFARLLKVEMAYHSRASETLLLVLRSTHIFADHMKPLGIEYLELLRAENNFGIPRSADKALFLSSVICKPMVDTASFGPEYWVDNLNSPIWHQDSTATFLSALGRMYQEAVPLAVKALFPEERRALCGLPVYPWDHSESYWYESRLSSAWRQRPFPHHSLLGERTVDSPDFSPIWRNMLSLEDVTWIADHKIRRDVVFPLAGYIAMAGEAIRQTTGVDVGYRLRDVEARKALVLTDFKATEVVTVLHAHTGVPAEGPSWYDFSIASCHGGSWLIHCTGQVSPLAETLSLSWEPESASQRSLPRELTPMRFYEAMARVGVVFGPEFQRLVDITSSATDPLAEARVMSPAPRENKRPFALHPTAIDACIQLLIVAAARGLCRNLDQLEVPVVVGNVEVVSRGSANLRALAQDFTQGVECVTENSKLALRMSGLQLAPLAAEVADQIDVHAGARLQWLPDFDFVDHSGLFNKPQRPSLEIELEEQLTLLCVLESMDKVAHIPPCHPHLAKYREWLALQVRMAEAGQYTLVEHAKEWVGLPRVKRQKLIQDTYAKILDLPGRHAYSVGIKRICEHADQIFTGEADTLDLLMQDDILAELYDSVSFGYGDFVRLLSSNRPNLRILEVSAGTGGTTEQTLRGLVDSSSLPPYSVYTFTDVSAGFFPQAKERFAYAPNMEFRTFDISQDGLIQGFEAASYDIILAPNVVHATASLKETLSNLEPLLKPNGFIILTELCSLIKSPNYIFGNFVGWWLGEADGRDWEPYVQPEQWDAELKAAGFTGVNAVVPDQDVPSYRLAATIISQPARKADVPEIDRAVTLLYQSADADIVERLQLYLRDSGWQVDKCQLGEEMPPKGQDIIASVRLESDFFGEDLSPDRLAAFQALIRHLDAEKVLWLCPRFQVRCKDPQSAQTLGVAQTVRTELNLPLFTLEIDTNETRFEELVHRVLQKIRTTKDEASLHADKEFVVTDGQVCIGRYHPFDLKKELPSRALTLDSAAAYLLVGGTGGLGRSMTTWMVEYGATELILLSRRAGKDRESQSLSQELEQMGCSVHLVAGSVENPEDIARSIASAKKPIKGVFQLAMVLQDAPLLEMTYSDWVNVNGPKVTGTWNLHHALKDQPLDFFWLASSILTAVDTPGQANYLATGTFLEAFCQYRHSLGLPASVLNICPVEGVGFVAENAHAKKNMKAQGIYTLREREFLDFVELSLIDSTPSAGGNTSPTATPPGPWVNRSQVVMGLRSEQGLGDPHNRASWRHNRRMRLYHNRRTQESESARDGKNGAKASALQAFLERVREMGDEGLLRGEGVDFLAFEVGKKIHDLMLKPDEEVEIGRTLAQIGLDSLMAIELRRWIKQVFGLTMSVLEIMGSGSLKQLAEDLAAKYAEKIQQ
Partially reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fumigermin that inhibits germination of spores of the inducing S.rapamycinicus, and thus helps the fungus to defend resources in the shared habitat against a bacterial competitor . The partially reducing polyketide synthase fngA alone is sufficient for the production of fumigermin . FgnA catalyzes the condensation of 3 malonyl-CoA units to an acetyl-CoA starter, and 3 methylations to yield fumigermin . It is remarkable that the five cluster genes including fgnA are conserved in distantly related fungi, supporting the assumption of a fumigermin cluster; it is thus possible that originally all five genes were functional, but that the genes encoding tailoring enzymes became inactive from mutations, similar to the case of the fgnA gene in strains A1163 and Af293 (Probable).
Q4WKW9
Q4UTA3
RS6_XANC8
30S ribosomal protein S6
Xanthomonas
MSRHYEVVFLVHPDQSEQVPAMIERYKSLIEGGNGTIHRLEDWGRRQLAYPIQNLVKAHYVLLNIEVDQAVLSELVESFRFNDAVLRHLVIKRDGPDTEQSLIMKSKDEKGDKPERSERRRRDDEEGDAAPAATDTDGDNAEAA
Binds together with S18 to 16S ribosomal RNA.
Q4UTA3
Q5VH50
MATK_BATMA
Intron maturase
Batis
MEEFQVYLELHKAHNFLYPLFFQEYIYALAHNHRLNRLNRSSLFQNGDYDNKFSSLIVKRLIFRMYQQNNFIISTKNLNQNTFFSHNKNLYYQIISVVLAVIVEIPFSIRFISSLEGKELVKSHNLQSIHSIFPFLEDKFSHLNYVLNVLIPHPIHLEILLQTLRYWIKDASSLHLLRFYLYEYSNLKNFFIPKKSTLNPRFFLFLYNSYVYQYESILFFLRKQSSHLQSNSFGILIERIYFYGKIESLLKVFIKKFQDILWLSKDPFMHYVRYRGKSILASKHGPLLISKWKYYFVNLWQCHFYVWSQSKRVHIKQLSKDYLNFLGYLSSLRLNFLVVRSQMLENSYLIDNVIKKFHTKIPMSSIIASLAKARFCNVLGHPISKSTWTDSSDSEILDRFVRIYRNLAHYYSGSSKKKNLYRIKYILRVSCVKTLARKHKSTVRAFLKRLGSDFLEEFLLEEEQVLSLMFSRVFSVSQRFYRVRIWYLDIFYINDFVNH
Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns.
Q5VH50
Q5HCR7
CLFB_STAAC
Fibrinogen-binding protein B
Staphylococcus
MKKRIDYLSNKQNKYSIRRFTVGTTSVIVGATILFGIGNHQAQASEQSNDTTQSSKNNASADSEKNNMIETPQLNTTANDTSDISANTNSANVDSTTKPMSTQTSNTTTTEPASTNETPQPTAIKNQATAAKMQDQTVPQEANSQVDNKTTNDANSIATNSELKNSQTLDLPQSSPQTISNAQGTSKPSVRTRAVRSLAVAEPVVNAADAKGTNVNDKVTASNFKLEKTTFDPNQSGNTFMAANFTVTDKVKSGDYFTAKLPDSLTGNGDVDYSNSNNTMPIADIKSTNGDVVAKATYDILTKTYTFVFTDYVNNKENINGQFSLPLFTDRAKAPKSGTYDANINIADEMFNNKITYNYSSPIAGIDKPNGANISSQIIGVDTASGQNTYKQTVFVNPKQRVLGNTWVYIKGYQDKIEESSGKVSATDTKLRIFEVNDTSKLSDSYYADPNDSNLKEVTDQFKNRIYYEHPNVASIKFGDITKTYVVLVEGHYDNTGKNLKTQVIQENVDPVTNRDYSIFGWNNENVVRYGGGSADGDSAVNPKDPTPGPPVDPEPSPDPEPEPTPDPEPSPDPEPEPSPDPDPDSDSDSDSGSDSDSGSDSDSESDSDSDSDSDSDSDSDSESDSDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSESDSDSESDSESDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSRVTPPNNEQKAPSNPKGEVNHSNKVSKQHKTDALPETGDKSENTNATLFGAMMALLGSLLLFRKRKQDHKEKA
Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps.
Q5HCR7
P80457
XDH_BOVIN
Xanthine oxidoreductase
Bos
MTADELVFFVNGKKVVEKNADPETTLLAYLRRKLGLRGTKLGCGEGGCGACTVMLSKYDRLQDKIIHFSANACLAPICTLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNQPEPTVEEIEDAFQGNLCRCTGYRPILQGFRTFAKNGGCCGGNGNNPNCCMNQKKDHTVTLSPSLFNPEEFMPLDPTQEPIFPPELLRLKDVPPKQLRFEGERVTWIQASTLKELLDLKAQHPEAKLVVGNTEIGIEMKFKNQLFPMIICPAWIPELNAVEHGPEGISFGAACALSSVEKTLLEAVAKLPTQKTEVFRGVLEQLRWFAGKQVKSVASLGGNIITASPISDLNPVFMASGTKLTIVSRGTRRTVPMDHTFFPSYRKTLLGPEEILLSIEIPYSREDEFFSAFKQASRREDDIAKVTCGMRVLFQPGSMQVKELALCYGGMADRTISALKTTQKQLSKFWNEKLLQDVCAGLAEELSLSPDAPGGMIEFRRTLTLSFFFKFYLTVLKKLGKDSKDKCGKLDPTYTSATLLFQKDPPANIQLFQEVPNGQSKEDTVGRPLPHLAAAMQASGEAVYCDDIPRYENELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTVTCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLKKGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKMLGVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRHPFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRLCKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLEGFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGALIHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAASVSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGYSFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVGEPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTGAPGNCKPWSLRV
Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
P80457
Q16629
SRSF7_HUMAN
Splicing factor, arginine/serine-rich 7
Homo
MSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRRSRSASLRRSRSGSIKGSRYFQSPSRSRSRSRSISRPRSSRSKSRSPSPKRSRSPSGSPRRSASPERMD
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
Q16629
B0R611
CBIM_HALS3
Energy-coupling factor transporter probable substrate-capture protein CbiM
Halobacterium
MHIMEGFLPGIWALVWFVVAIPVISYGALKTARLARNDELNKSHIAVAAAFIFVLSALKIPSVTGSTSHPTGTGIAVVLFGPAVTAFLSAIVLLYQALLLGHGGLTTLGANVVSMGVVGPVAGWVVFRALNPYLDLQKATFAAAVIADWTTYLVTSIQLGVAFPSGPGVAGVVDSIVRFASVFSITQIPIGIVEGALAAGLIGYIAMSRQSIKTRLGVTA
Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
B0R611
C6BUK3
DAPAT_MARSD
LL-diaminopimelate aminotransferase
Maridesulfovibrio
MPEFKLADRLATLPPYLFAEIDRLKAEVAAQGVDIISLGIGDPDLPTPDFIIEALHKAAKNPVNHQYPSYVGLLTFRQAVADWYKERFDVELDATKEVVSLIGSKEGIAHFPLAFVNPGDLVLVASPNYPVYPVASGFAGGEVEIVPLLEENDFLPNLDAISDEKWDKCKIFFVNYPNNPTSATATPEFYAELVAKAKKHNVIIAADAAYTEVYYDEDKKPISILETPGAKDVAIEFHSLSKTYNMTGWRCGMAVGNASLVAGLGKIKENVDSGIFQAVQEAGIVALKEGEPYVKEFRKIYKERRDCVIEALEKINISCKVPDASIFVWAKTPEGYTSSEFVSKLLKETGVVVTPGNGFGESGEGYFRISLTVDTDRLKEAVSRISKL
Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
C6BUK3
A4QWP8
MEP_MAGO7
Fungalysin MEP
Pyricularia
MRYSLSLALLGVAAVTVVAHPHTPGRHGVERRAIDLDAFRLQPTAEYVPKEEVPDQSSLAFISNDNYVDVATDLVKSVAPGIEFRVVGDHYVGTNGVAHVNFKQTAHGIDIDNADFNVNVRDGKVFSYGNSFFTGKIPEESPLKKRDFSDPTVALTGATTVLQLPISGEAKAEAKEGTETYTLKGTSGAVSDPEARLVYLVRDDSLALTWRVETDIEDNWLLSYVDANNKEQVHGVVDYVSHASFQVYPWGTNDPLEAGAARVTLTDPWDKASSPFGWLSDGTSTYTTTRGNNAIAQSNPSGGTAYLNNYRPTNANSIFSYPWTPAMSPPSSFVDFSATQLFYTANVFHDLLYKLGFTEAAGNFQVNNNGKGGLGNDQVILNTQDGSGTNNANFATPPDGQNGRMRMYIWTYTTPQRDSSLEAGVVIHEYTHGLSNRLTGGPSNSGCLSALEAGGMGEGWSDFFATAARIKQNDTADTDYPMGEWVAANPKGIRAYPYSTSLTRNPQTYATTNTLSTVHPIGNVWATVLYEVLWALVGKHGLQVSTFPTFDASGVPTSGNFLAQKLVLDGMALQPCNPNFVQARDAIIDADQALTGGANKCELWTAFAKRGLGSGAKYAASKRSVESKTIPAGVC
Secreted metalloproteinase that allows assimilation of proteinaceous substrates.
A4QWP8
Q6NWG0
TSN36_DANRE
Tetraspanin-3c
Danio
MDCGIITSKTILLLLSLIFWAAGAALAYVGSYVIKSYNNFEDFMSDRHTLIPAAIIIGVAVVMFIIGFVGCCATLRESKVGLGLFLIIIMLIFAAEVTAFVFGIIYRGRIRGDLEKSMNDVFLKYDGLNSETHAVDYLQSQLECCGVKNQTDWTLTSWFAQHNNTVPQSCCKANMTQCTGQLSQPDLLNTQGCEAKLEQVLQDVLSYAMLVILGFAIIKFFGMLSVCVITCKSKKNEYQPLYA
Plays a role in migration and segregation of pigment cells (melanophores and xanthophores). Contributes to pigment stripe patterning in the epidermis.
Q6NWG0
O14640
DVL1_HUMAN
DSH homolog 1
Homo
MAETKIIYHMDEEETPYLVKLPVAPERVTLADFKNVLSNRPVHAYKFFFKSMDQDFGVVKEEIFDDNAKLPCFNGRVVSWLVLAEGAHSDAGSQGTDSHTDLPPPLERTGGIGDSRPPSFHPNVASSRDGMDNETGTESMVSHRRERARRRNREEAARTNGHPRGDRRRDVGLPPDSASTALSSELESSSFVDSDEDGSTSRLSSSTEQSTSSRLIRKHKRRRRKQRLRQADRASSFSSITDSTMSLNIVTVTLNMERHHFLGISIVGQSNDRGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDVNFENMSNDDAVRVLREIVSQTGPISLTVAKCWDPTPRSYFTVPRADPVRPIDPAAWLSHTAALTGALPRYGTSPCSSAVTRTSSSSLTSSVPGAPQLEEAPLTVKSDMSAVVRVMQLPDSGLEIRDRMWLKITIANAVIGADVVDWLYTHVEGFKERREARKYASSLLKHGFLRHTVNKITFSEQCYYVFGDLCSNLATLNLNSGSSGTSDQDTLAPLPHPAAPWPLGQGYPYQYPGPPPCFPPAYQDPGFSYGSGSTGSQQSEGSKSSGSTRSSRRAPGREKERRAAGAGGSGSESDHTAPSGVGSSWRERPAGQLSRGSSPRSQASATAPGLPPPHPTTKAYTVVGGPPGGPPVRELAAVPPELTGSRQSFQKAMGNPCEFFVDIM
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
O14640
C3N0D7
CAPPA_SULIA
Phosphoenolpyruvate carboxylase
Sulfolobus
MRIIPRTMSTQHPDNAKVPEWAKSEVIEGEDEVKEAFLAYSMYGVHEVMWDAEGKDVDTHVVRKLLSNYPDYFREHILGKDVFLTYRLPNPKVEGADRKVFAETMESIPITYDLAEKFYGNGITVPVFEVILPMTTSNLEIISVARYYEKAVANEDELELYNGVKVKDLVGEIYPKVIEVIPLVEDRDSLQNIDNIVEGYYKVIKPKYMRVFLARSDPAMNYGMITAVLSVKIALSELYKLSESLNFEIYPIIGVGSLPFRGHLSPENYEKVLEEYKGVYTYTIQSAFKYDYDYDKVKSAISSINNSRIGPAKILEKYEEDVLRKITILYTERYQPIIESLANAINDVSVLLPRRRARKLHIGLFGYSRSAGKVSLPRAISFVGSLYSIGIPPELIGISSLSNLDEKEWDIFKQNYVNFKHDLQTAARFFNWESFELIKDIWKISEDTIAKIKEDIDYAESVIGIKLGDIDYDSRKHILMSSLFLLSFKEKILQESKKYLYEMALIRRSLG
Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.
C3N0D7
Q47758
DDL_ENTFA
D-alanylalanine synthetase
Enterococcus
MKIILLYGGRSEEHDVSVLSAYSVLNAIYYKYYQVQLVFISKDGQWVKGPLLSERPQNKEVLHLTWAQTPEETGEFSGKRISPSEIYEEEAIVFPVLHGPNGEDGTIQGFMETINMPYVGAGVLASANAMDKIMTKYLLQTVGIPQVPFVPVLRSDWKGNPKEVFEKCEGSLIYPVFVKPANMGSSVGISKVENREELQEALEEAFRYDARAIVEQGIEAREIEVAILGNEDVRTTLPGEVVKDVAFYDYDAKYINNTIEMQIPAHVPEEVAHQAQEYAKKAYIMLDGSGLSRCDFFLTSKNELFLNELNTMPGFTDFSMYPLLWENMGLKYSDLIEELIQLALNRFK
Cell wall formation.
Q47758
Q58DT1
RL7_BOVIN
60S ribosomal protein L7
Bos
MEGAEEKKKKVPAVPETLKKKRKNFAELKIKRLRKKFAQKMLRKARRKLIYEKAKHYHKEYRQMYRTEIRMARMARKAGNFYVPAEPKLAFVIRIRGINGVSPKVRKVLQLLRLRQIFNGTFVKLNKASINMLRIVEPYIAWGYPNLKSVNELIYKRGYGKINKKRIALTDNALIARSLGKYGIICMEDLIHEIYTVGKRFKEANNFLWPFKLSSPRGGMKKKTTHFVEGGDAGNREDQINRLIRRMN
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs.
Q58DT1
P32879
3S11_AIPLA
Short neurotoxin A
Aipysurus
LTCCNQQSSQPKTTTDCADNSCYKKTWQDHRGTRIERGCGCPQVKPGIKLECCKTNECNN
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission.
P32879
Q8A483
RL16_BACTN
50S ribosomal protein L16
Bacteroides
MLQPKKTKFRRQQKGRAKGNAQRGNQLAFGSFGIKALETKWITGRQIEAARIAVTRYMQRQGQIWIRIFPDKPITRKPADVRMGKGKGAPEGFVAPVTPGRIIIEAEGVSYEIAKEALRLAAQKLPITTKFVVRRDYDIQNQNA
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
Q8A483
B7HHH6
CYSH_BACC4
Thioredoxin-dependent 5'-adenylylsulfate reductase
Bacillus cereus group
MLTYETWEENVVSFSEEDETKGALSVLNWAYKEYKDEVVYACSFGVEGMVLLHIINQVNPSAKVVFLDTNVHFQETYELIQKVRERFPSLNIIEKQPELTLDEQAKLHGEKLWESNPNLCCKIRKILPLEKSLVVEKAWISGLRREQSETRKHTKFINQDHRFQSIKVCPLIHWTWKEVWRYVYKHSLPYNPLHDVGYPSIGCEKCTLPVGDGGDSRDGRWAGKVKTECGLHYQ
Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.
B7HHH6
P06389
RK22_TOBAC
50S ribosomal protein L22, chloroplastic
Nicotiana
MLKKKKTEVYALGEHISMSADKARRVINQIRGRSYEETLMILELMPYRACYPILKLIYSAAANASYNMGSSEANLVISKAEVNGGTTVKKLKPRARGRSFPIKRSTCHITIVMKDISLDDEYVEMYSLKKTRWKKKSTAMPYRDMYNSGGLWDKK
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
P06389
Q0I7X4
CY550_SYNS3
Low-potential cytochrome c
unclassified Synechococcus
MASFFSTLRRSLNRLLIALPVLLGLMISTPAQAAQWDAETLTVPADGDGALVTFSEQEIKTGRKVFNVSCGTCHAGGITKTNQNVGLDTETLALATPARDNVASLVDYLQDPTSYDGEYSIADLHPSMRSRDLYPAMRDLTDEDLRLMSGYILVAPKVLGVDWGGGKIYF
Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II.
Q0I7X4
Q5L411
RL5_GEOKA
50S ribosomal protein L5
Geobacillus thermoleovorans group
MNRLKEKYLNEVVPALMSKFNYKSIMQVPKIEKIVINMGVGDAVQNPKALDSAVEELTLIAGQRPVVTRAKKSIAGFRLRQGMPIGAKVTLRGERMYEFLDKLISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVNKVRGMDIVIVTTANTDEEARELLALLGMPFQK
This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.
Q5L411
Q8CTZ3
BIOW_STAES
Pimeloyl-CoA synthase
Staphylococcus
MYSIKMRASHEDIHISGAETMCEFEDLENYLKKYFNKAFNHENGNIDFLNLKIEKVKAPIQTLVALPVVENLNDTLTQLAKQTGVSEYALNKGLEFIKNDITYTGAIILSAQTGQRLDSTEQRGIRVTQLAFKTCKCNGEISERVKDARALATCINAFEGVKAELCVSDDLHYTTGYFASPKLGYRRIFNIKEKGTRHGGRIIFVDEGIHLNEYVSFLETVPKEIIEK
Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP.
Q8CTZ3
Q14296
FASTK_HUMAN
Fas-activated serine/threonine kinase
Homo
MRRPRGEPGPRAPRPTEGATCAGPGESWSPSPNSMLRVLLSAQTSPARLSGLLLIPPVQPCCLGPSKWGDRPVGGGPSAGPVQGLQRLLEQAKSPGELLRWLGQNPSKVRAHHYSVALRRLGQLLGSRPRPPPVEQVTLQDLSQLIIRNCPSFDIHTIHVCLHLAVLLGFPSDGPLVCALEQERRLRLPPKPPPPLQPLLRGGQGLEAALSCPRFLRYPRQHLISSLAEARPEELTPHVMVLLAQHLARHRLREPQLLEAIAHFLVVQETQLSSKVVQKLVLPFGRLNYLPLEQQFMPCLERILAREAGVAPLATVNILMSLCQLRCLPFRALHFVFSPGFINYISGTPHALIVRRYLSLLDTAVELELPGYRGPRLPRRQQVPIFPQPLITDRARCKYSHKDIVAEGLRQLLGEEKYRQDLTVPPGYCTDFLLCASSSGAVLPVRTQDPFLPYPPRSCPQGQAASSATTRDPAQRVVLVLRERWHFCRDGRVLLGSRALRERHLGLMGYQLLPLPFEELESQRGLPQLKSYLRQKLQALGLRWGPEGG
Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels.
Q14296
Q9QXW0
FBXL6_MOUSE
F-box protein FBL6
Mus
MAPVASRRVRRRVRSSKRPDARGRSAEDWWWDRLAPRGSGYHLLQADSMLLVLPDLEPPRARAHRRARRRAPRSLARGPTAVAKPRTKPRPEPSLDQGLDSGWGDRIPLEVLVHIFGLLVAAHGPMPFLGRAARVCRHWHEATSHPSLWHTVTLSPSLVGRAGKGNLKGEKKLLACLEWLVPNRFSQLQSLTLIHWKSQVHSVLELVSKFCPRLTFLKLSDCHTVTAETLVMLARACCQLHSLDLHHSMVESTAVVSFLEEAGSRMRKLWLTYSSQTTAILGALLDNCCPQLQVLQVSTGMNCNNTPLQLPVEALQKGCPQLQVLRLLNLIWLPKPCGRGVPQGPGFPSLEELCLAGSTCNFVSNEVLGRLLHRSPKLRMLDLRGCARVTPSGLCHLPCQELEQLYLGLYGISDGLTLAKDGSPLLTRKWYHTLRELDFSGQGFSEKDLEQALAVFSGTPGGLHPALCSLNLRGTRVTPSTVSSVISGCPGLLYLNLESCRCLPRGLKRVYRGLEEVQWCLEQLLTSPPSAKEPT
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
Q9QXW0
Q3SK28
IHFA_THIDA
Integration host factor subunit alpha
Thiobacillus
MTTLTKADLAELLFEKVGLNKREAKDVVESFFDEIRLALEKGDIVKLSGFGNFQCREKPQRPGRNPKTGEEMPISARRVVTFHASQKLKSQVEGARIGTPSQE
This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control.
Q3SK28
Q9WVC6
SGK1_MOUSE
Serum/glucocorticoid-regulated kinase 1
Mus
MTVKAEAARSTLTYSRMRGMVAILIAFMKQRRMGLNDFIQKIASNTYACKHAEVQSILKMSHPQEPELMNANPSPPPSPSQQINLGPSSNPHAKPSDFHFLKVIGKGSFGKVLLARHKAEEVFYAVKVLQKKAILKKKEEKHIMSERNVLLKNVKHPFLVGLHFSFQTADKLYFVLDYINGGELFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCKENIEHNGTTSTFCGTPEYLAPEVLHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDNILNKPLQLKPNITNSARHLLEGLLQKDRTKRLGAKDDFMEIKSHIFFSLINWDDLINKKITPPFNPNVSGPSDLRHFDPEFTEEPVPSSIGRSPDSILVTASVKEAAEAFLGFSYAPPVDSFL
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na(+) retention, renal K(+) elimination, salt appetite, gastric acid secretion, intestinal Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis.
Q9WVC6
P23620
PHOB_PSEAE
Phosphate regulon transcriptional regulatory protein PhoB
Pseudomonas
MVGKTILIVDDEAPIREMIAVALEMAGYECLEAENTQQAHAVIVDRKPDLILLDWMLPGTSGIELARRLKRDELTVDIPIIMLTAKGEEDNKIQGLEVGADDYITKPFSPRELVARLKAVLRRTGPGDSEAPIEVGGLLLDPISHRVTIDGKPAEMGPTEYRLLQFFMTHQERAYTRGQLLDQVWGGNVYVEERTVDVHIRRLRKALGEVYENLVQTVRGTGYRFSTKS
This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited.
P23620
Q8EHD3
UPPP1_SHEON
Undecaprenyl pyrophosphate phosphatase 1
Shewanella
MDTFQVIILALIQGLTEFLPISSSAHLILPAQLLGWEDQGLSFDVAVNTGSLFAVVIYFRHELWAMFKAWIASIVKGQHSDDSKLAWWIILATLPAVFFGFMAKDFIATHLRNTGVIAVTTVVFGLLLWWADKMSRHDLTIYQTGWRKALLIGFAQALALIPGTSRSGATMTAALMLGLSRDAAARFSFLMSVPVSLGAAILVGKDLAESPLPIDYQALTLGTVISFAAAYLCIHYFLKIISRMGMTPFVIYRLALGAVLCGFIFL
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Q8EHD3
O33406
MBHL_AFIC5
Membrane-bound hydrogenase large subunit
Afipia
MSVIQTPNGYKLDNSGRRVVVDPVTRIEGHMRCEVNVDSNNVIRNAVSTGTMWRGLEVILKGRDPRDAWAFVERICGVCTGCHALASVRAVENALDIRIPPNAHLIREIMAKVLQWHDHVVHFYHLHALDWVNPVNALKADPKATSELQQLVGPNHPMSSPGYFRDIQNRLKRFVESGELGIFKNGYWDNPAYKLSPEADLMATAHYLEALDIQKEIVKIHTIFGGKNPHPNFMVGGVPCAINMDGDLAAGAPLNMERLNFVRARIEEAYEFSKNVYIPDVIAIATFYKGWLYGGGLSATNVMDYGDYAKVNYDKSTDQLKGGAILNGNWNEVFPVDAADPEQIQEFVAHSWYKYPDEAKGLHPWDGVTEHNYALGPNTKGTRTDIKQLDEAAKYSWIKSPRWRGHAVEVGPLSRYILNYAQGNQYVIEQVDSSLAAFNKLAGTNLTPKQALPSTIGRTLARALEAHYCAAMMLDDWKELIGNIKAGDSSTANVEKWDPSTWPKEAKGYGLVAAPRGANGHWIRIKDGKIANYQCIVPTTWNGSPRDPAGNIGAFEASLMNTPMERPEEPVEILRTLHSFDPCLACSTHVMSEDGENLAKVTVR
This enzyme recycles the H(2) produced by nitrogenase to increase the production of ATP and to protect nitrogenase against inhibition or damage by O(2) under carbon- or phosphate-limited conditions.
O33406
Q8D3J7
ATPF_WIGBR
F-type ATPase subunit b
Wigglesworthia
MNINATIFGQTIAFFLFVFFCMKYIWPNLISLVEKRRENIAQALNEAKQAKLNLKISKEKAKKRIESAQIKCKNIINEANETKKLLIEEAKKEAIKIKEHIISQGRLDILDEKKRMCEDLKTKISEIIVMSVEKIIESSINKKISDNIIERSISKINKIKG
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
Q8D3J7
Q61249
IGBP1_MOUSE
p52
Mus
MAASEDELLLPRLPELFETSKKLLEDVEVATEPTGSRTIQDKVSKGLELLEKAAGMLSQLDLFSRNEDLEEIASTDLKYLMVPALQGALTMKQVNPSKRLDHLQRAREHFVHFLTQCHCYHVAEFQLPQTKTNSAENNTASSSMAYPNLVAMASQRQAKIERYKQKKEVEHRLSALKSAVESGQADDERVREYHLLHLRRWIAVSLEELESIDQEIKILKEKDSPREETACHSSLPEKPPMKPFILTRNKAQAKVFGTGYPSLATMTVSDWYEQHQKYGVLPDRGIAKPASADFQRAAQQQEDQEQKDEESEEKALHRMREWDDWKDTHPRGYGNRQNMG
Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.
Q61249
Q04K71
GUAC_STRP2
Guanosine 5'-monophosphate oxidoreductase
Streptococcus
MLNEFPIFDYEDIQLIPNKCVIKSRAEADTSVTLGNHTFKLPVVPANMQTILDENVAEQLAKGGYFYIMHRFDEAGRIPFIKRMHDQGLIASISVGVKDYEYDFVSQLKADAPEYITIDIAHGHADSVISMIQHIKKELPDTFVIAGNVGTPEAVRELENAGADATKVGIGPGKVCITKVKTGFGTGGWQLAALRWCAKAARKPIIADGGIRTHGDIAKSIRFGASMIMIGSLFAGHIESPGKTIEVDGEQFKEYYGSASQYQKGAYKNVEGKRILLPAKGHLQDTLTEMEQDLQSAISYAGGRQVADLKHVDYVIVKNSIWNGDASH
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Q04K71
Q1GBL8
RL3_LACDA
50S ribosomal protein L3
Lactobacillus
MTKGILGRKVGMTQIFTKDGVLVPVTVIEATPNVVMQVKTVENDGYEAVQLGYQDKREVLSNKPEKGHADKAKTSPKRFIRELRGVELSDYEVGSEVTVETFKEGDVVNVTGTSRGHGYQGNIKRHHQSRGPETHGSRYHRIPGSMGSIINRVPKGKKLPGHMGVKTVTIENLVVEKVVADKNVLMIKGNVPGAKNSLIVVKSSAKASK
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
Q1GBL8
B2VEK6
ASTB_ERWT9
N-succinylarginine dihydrolase
Erwinia
MSAREVNFDGLPGLTHHYAGLSFGNEASARHQHQVSNPKLAALQGLKKMKTLADLGYAQGVIPPHERPNIEALRQLGFSGSDAQVLAQAAKQAPKLLSAVSSASAMWVANAATVSPSVDSRDGRVHLTVANLNNKYHRSIEAPTTAALLRAIFRDDEHFSVHDALPQVALFGDEGAANHNRFSNGYGEPGVQLFVYGCAQAGGIRPLHYPARQTREASEAVARLNQLDAARTLYAQQDPVVIDAGVFHNDVIAVSNQQTLFCHQRAFLNQPQLMARLAQKVPGFNLIEVPDERVSVADAVATYLFNSQLLSKDNGKMLLILPEEARRHAGVWRWLTEMVAGDGTIDELKVLDLRESMCNGGGPACLRLRVVLNAQQQAAVNPAVMMNETLYATLCGWVERHYRDRLSQADLADPQLLSEGREALDELTKLLDLGHVYRFQQ
Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2).
B2VEK6
B4TMY9
TORD_SALSV
Chaperone protein TorD
Salmonella
MNKQPALAQEQYACVYAWLALLFFREVDDEGLIQLQSAEIADWLALLKRQPALAASVALLEQKIAALSLRQDAQLELAADFCGLFLMTDKKSALPYASQYPQQEPGMIKHLLLEAGMEVNDDFKEPTDHLAIYLELLSHLHFSLGESFQQRRMNKLRQKTLSSLLEWLPEFTNNCFKHDSYGFYAALSQLLLAIVRFDDGKEDLSIVAAE
Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor.
B4TMY9
Q8RSW1
PSBL_SYNP2
Photosystem II reaction center protein L
unclassified Synechococcus
MERNQNPNRQPVELNRTSLYLGLLLIAVLGILFSSYFFN
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation. This subunit is found at the monomer-monomer interface and is required for correct PSII assembly and/or dimerization.
Q8RSW1
Q6PB90
PCDBE_MOUSE
Protocadherin beta-14
Mus
METSLHKAPQKRQVTAIIFLLLLWEAGSATITYSVLEETDRGSLVGNLAKDLGLSLRELITRGAQILSKGNKQLLQLEQKSGNLLLKEKLDREELCGSTNPCILHFQVLLKSPVQFIQGEIQLQDVNDHAPEFMEDEILLKILESSLPGAVFPLKIAQDLDVGSNTVQNYTISTNAHFHLLTRNHSDGRKYPELVLDKALDREEQAQIRLTLTAMDSGSPPKTGTTQVVIVVLDINDNAPEFAQGLYEVQVQENSPVGSLVLTVSARDLDAGTHGELSYSLFQSSNQVLQAFEVNTDTGEIRVRKLLDFEEIQSYRMEIEASDGGGLSGKCTVVIHVMDVNDNAPELTMSVLISEIPENSPETIVAIFGISDPDSGDNGKMVCSVQDRLPFLLKPNEENFYTLVTERALDRESRAEYNITITVSDMGTPRLTTQHTITVQVSDINDNAPAFTHTSYTMFVRENNSPALHIGTISATDSDSGSNAHITYSLLPPHDPQLALNSLISINADNGQLFALRALDYEALQAFEFHVGATDGGSPALSSQALVRVVVLDDNDNAPFVLYPMQNASAPCTELLPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKTTEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLLVKDNGEPPHSASVTLHVLLVDGFSQPYLPLPEVARDPAQEDVLTLYLVIALASVSSLFLVSVLLFVGVRLCRKAGETSLGGCSVPEGHFPGHLVDVSGTGTLSQSYQYEVCLTGGTGTNEFKFLKPVLPNFLNEGGYRNTEENSNFRDSLGFS
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Q6PB90
P08850
HBA_ACCGE
Hemoglobin alpha-A chain
Accipiter
MVLSANDKTNVKNVFTKIGGHAEEYGAETLERMFTTYPPTKTYFPHFDLHHGSAQIKAHGKKVVGALIEAVNHIDDIAGALSKLSDLHAQKLRVDPVNFKLLGQCFLVVVAIHHPSVLTPEVHASLDKFLCAVGNVLTAKYR
Involved in oxygen transport from the lung to the various peripheral tissues.
P08850
P61430
SYCP2_ARATH
Synaptonemal complex central region protein ZYP1b
Arabidopsis
MQKLGFPAMKSFDQLRSLPGSAKTYFFSTRPPQDSVSSGSFSNLKLTAEKLVKDQAAMRTDLELANCKLKKSMEHVYALEEKLQSAFNENAKLRVRQKEDEKLWRGLESKFSSTKTLCDQLTETLQHLASQVQDAEKDKGFFETKFNTSSEAINSLNQQMRDMSLRLDAAKEEITSRDKELEELKLEKQHKEMFYQTERCGTASLIEKKDAVITELETTAAERKLKIEKLNSQLEKLHLELTTKEDEVIHLVSIQEKLEKEKTNVQLSSDELFEKLVRSEQEVKKLDELVHYLIAELTELDKKNLTFKEKFDKLSGLYDTHFMLLRKDRDLASDRAQRSFDQLQGELFRVAAEKEALESSGNELSEKIVELQNDKESLISQLSGVRCSASQTIDKLEFEAKGLVLKNAETESVISKLKEEIDTLLESVRTSEDKKKELSIKLSSLEIESKDKYEKLQADAQRQVGELETLQKESESHQLQADLLAKEVNQLQTIIEEKGHLILQCNENEKNINQQIIKDKELLATAETKLAEAKKQYDLMLESKQLELSRHLKELSQRNDQAINEIRRKYDVEKHEIINSEKDKVEKIIKELSTKYDKGLSDCKEESKRQLLTIQEEHSSRILNIREEHESKELNLKAKYDQELRQNQIQAENELKERITALKSEHDAQLKAFKCQYEDDCKKLQEELDLQRKKEERQRALVQLQWKVMSDNPPEEQEVNSNKDYSHSSVKVKESRLGGNKRSEHITESPFVKAKVTSVSNILKEATNPKHHSKVTHREYEVETNNGRIPKRRKTRQTTMFQEPQRRSTRLTPKLMTPTIIAKETAMADHPHSANIGDLFSEGSLNPYADDPYAFD
Required for chromosome synapsis and normal fidelity of crossing over.
P61430
Q6AYP0
ALLC_RAT
Allantoate amidinohydrolase
Rattus
MADTPKEGKLTRFLDFTQLIDLASECVGGKVLFATDDFFGPAENLIKSNNPSFKENEYTEFGKWVDGWETRRKRIPGHDWCVIQLGIQGIIRGIDVDISYFSGNYAPRMSIQAANLSEDTVTNIPPRGVKMGAAATSEEFVAITELKSHSWDYLVPMSELKPGDPDSSHNYFFVNSQQRWTHIRLNIFPDGGVARLRVYGTGQRDWAALDSTEPVDLVAIAFGGVCVGFSNAHFGHPNNMIGVGDPKSIADGWETARRLDRPPVLEGNENGFLQVPGCEWAVFRLAHPGVITQIEIDTKYFKGNSPDSCKVDGCILTTLEEEDMIRQKWSLPAHKWKPLLPVTKLTPNQNHLLDSLTLELQDVITHARITIAPDGGVSRLRLKGFPSSICLLRPLREKPMLRFSLKAGFRANL
The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.
Q6AYP0
P52803
EFNA5_HUMAN
EPH-related receptor tyrosine kinase ligand 7
Homo
MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVHDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion.
P52803
A9A2G6
HPCAL_NITMS
3-hydroxypropionyl-coenzyme A synthetase [ADP-forming]
Nitrosopumilus
MAAVKKIFDEIIETDHKVITEESSKSILKNYGVKVPPYALVTSAEEAAKEAKKIGFPLVMKVVSPQILHKTDVGGVKVGLDNVADVKKTFTDMYGRLSKKKGVNVKGILLEKMVPKGVELIVGIQNDSQFGPIIMVGMGGIMTEVMKDVAFRMLPITTSDAKSMLNELKGSKLLKGFRGSEPIDTNLVAKMLVNIGKLGVENADYINSIDFNPVIVYPKSHYVVDAKIILNKEKKKNSISKAKPSITDMETFFTPKSVALVGASASPGKIGNSILDSLVNYDFKGKVYPINPKADKIFGQKCYPSVADIPGKVDLVVVSVDLSMTPPVLEDCAKKGVHSVVIVSGGGKELGGERAAYEAEVARLSKKHKIRIIGPNCIGMFNAANRLDCAFQGQERMVRSKLGPVAFFSQSGTMGISMLESADTFGLSKMISFGNRSDVDEADMIWYAANDPQTKVIGLYVEGFGDGRKFINVAKRVMKEKKKPIVIWKSGRTAAGAKQAASHTGSLGGSNAIIMGAFKQAGIISVDSYQELAGVLKALAWQPAAKGNKVAMTSNGAGPMIGGIDQLEKFGLAIGKLSPKLLKKMKSRFPPAVPIHNGNPADVGGGATADDYQFVIQQFMDEKNIDIAMPWFVFQDDPLEETIVDHLAGFQKKAKKPLLCGGNGGPYTEKMIKLIEKHNVPVYQDLRTWVAAASALHQWGKISKK
Involved in thaumarchaeal hydroxypropionate/hydroxybutyrate (HP/HB) cycle, a modified version of the autotrophic HP/HB cycle of Crenarchaeota. Catalyzes the formation of 3-hydroxypropionyl-CoA, ADP and phosphate from 3-hydroxypropionate, coenzyme A (CoA) and ATP. Can also use 4-hydroxybutyrate, propionate and butyrate, with poor catalytic efficiency.
A9A2G6
P0A3S0
NCZS_STRML
Mitomalcin
Streptomyces
AAPTATVTPSSGLSDGTVVKVAGAGLQAGTAYDVGQCAWVDTGVLACNPADFSSVTADANGSASTSLTVRRSFEGFLFDGTRWGTVDCTTAACQVGLSDAAGNGPEGVAISFN
NCS has antibiotic activity (for Gram-positive bacteria) and antitumor activity (for certain mouse tumors). NCS binds non-covalently to a chromophore which is the cytotoxic and mutagenic component of the antibiotic. The chromophore binds to DNA as a weak intercalator and causes single- and double-strand breaks.
P0A3S0
P29754
AGTRA_MOUSE
Angiotensin II type-1 receptor A
Mus
MALNSSTEDGIKRIQDDCPRAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSAAKKPASCSEVE
Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C.
P29754
A9BTA2
RPOZ_DELAS
Transcriptase subunit omega
Delftia
MARITVEDCLEQIPNRFQLVLAATYRARMLSQGHTPRIETKNKPGVTALREIAEGKVGLEMLKKVPG
Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
A9BTA2
Q92NM8
DNLJ_RHIME
Polydeoxyribonucleotide synthase [NAD(+)]
Sinorhizobium
MLNQRKSVEQLNEAEAAEELAFLAAELARHDMLYHGKDAPEISDADYDALKRRNDLIEERFPVLVREDSPSRKVGAAPSLTFAPVVHARPMLSLDNTFSDEDARAFVAGVYRFLGKLPDGSIAFTAEPKIDGLSMSLRYENRRLVTAATRGDGTTGENVTANVRTIGMIPQTLPADAPDVVEIRGEIYMAKSDFAALNAEMAAQGRPLYVNPRNTASGSLRQLDAKVTANRKLRFFAYAWGEMSAMPADTQLGMVETFKAWGFPVNPLMQRFFSADELLEHYHHIERERPDLDYDIDGVVYKVDRLDLQARLGFRSRSPRWATAHKFPAEQAFTRLKGIDIQVGRTGALTPVARLEPITVGGVVVTNATLHNEDYIRGVGNTGEPIRDGRDVRIGDMVIVQRAGDVIPQIVDVVMDERPEGAEPYRFPTTCPICGSHAVRDINEKTGKVDAVRRCTGGFVCRAQAVEHLKHFVSRNAFDIEGLGSKQIEFFFESEDENLRIRTAPEIFTLERRQEASLNKLENTDGFGKVSVRKLYEAINARRSIALHRLIYALGIRHVGETTAKLLARSYGSYEHFGAAMTEAAGFSGDAWNELNSIDGIGEVVARAIVEFYKEPRNLKVVSELLQEVTPESAELPVATDSPVAGKTVVFTGSLEKMTREEAKAKAESLGAKVAGSVSKKTDIVVAGPGAGSKLDKARELGVQTMDEDEWLALIGG
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Q92NM8
P50864
CWLD_BACSU
Cell wall hydrolase
Bacillus
MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIYLDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKGYSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYIQDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVASSIYKGILRYFTEKGDPPE
Cleaves the peptide side chain from the N-acetylmuramic acid residues in peptidoglycan. This is a step in the formation of muramic delta-lactam residues in spore cortex.
P50864