accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
Q62737
CY24A_RAT
p22-phox
Rattus
MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVLICLLEYPRGKRKKGSTMERCGQKYLTAVVKLFGPLTRNYYVRAVLHLLLSVPAGFLLATILGTVCLAIASVIYLLAAIRGEQWTPIEPKPKERPQVGGTIKQPPTNPPPRPPAEVRKKPSEAEEEAASAGGPQVNPIPVTDEVV
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.
Q62737
Q1I2G6
HEM6_PSEE4
Oxygen-dependent coproporphyrinogen-III oxidase
Pseudomonas
MTSRTEAVKAYLLDLQDRICSALETEDGGARFVEDAWVRDAGGGGRTRVIGEGKVIEKGGVNFSHVFGAGLPPSASAHRPELAGRGFEALGVSLVIHPHNPHVPTSHANVRFFIAEKEGEEAVWWFGGGFDLTPYYGNEEDCVHWHRVAEQACAPFGADVYPRYKAWCDRYFHLKHRGEPRGIGGLFFDDLNEWDFDTCFAFMRAIGDAYVDAYLPIIQRRKDTPYTAKQREFQEYRRGRYVEFNLVYDRGTLFGLQSGGRTESILMSLPPQVRWGYDWKAEPGSEEARLTDYFLQDRDWLAQ
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
Q1I2G6
B0JI44
PCXA_MICAN
Proton extrusion protein PcxA
Microcystis
MNLNRILQGVNQWLLQTPERSLDEAYHAALKIKEIEDKHFQGRKVANEFSNYGSSTNSYFIAEVKGYLQKIKVRLTEFKASRSIVNTFGPNQPTINNGVITVTTDVCLKKLQFIDSIIGKYQDNYWQEDIQDVPKSIQNRNFEQETAKNKTSRNRSFLAAGSIEDEEIIKSNKSQKATEKPGVLPRSFVNTFNRIKQEIDPQAEESEEAVLKKFRNSRYKTAISLKFILLLIIVPLLTQQLTKTFLITPLVNKYFQQQEQFIFINQDLEEEAFSELRRFEEALHFRGMIGLAPKLSNEEIEGEITKKAAVLSEEFRQRGLNAIANIFADICSLIAFGFVVAFSRREIEIVKSFLDGILYNLSDSAKAFLIILFTDIFVGFHSPHGWEVILEGLSRHFGLPENRQFNFLFIATFPVILDTVLKYWIFRYLNRISPSAVATYRNMNE
Involved in light-induced Na(+)-dependent proton extrusion. Also seems to be involved in CO(2) transport.
B0JI44
Q7ZX60
P4R3A_XENLA
SMEK homolog 2-A
Xenopus
MSDTRRRVKVYTLNEDRQWDDRGTGHVSSTYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVEVTQDPIDESEEERFEEMPETSNLIDLPTCELGKLEEIADLVTSVLSSPIRREKLALALENEGYIKKLLQLFQTCENLDNTEGLHHLYEIIRGILFLNKAALFEVMFSDECIMDVVGCLEYDPALAQPKRHREFLTKTAKFKEVIPITDSELRQKIHQTYRVQYIQDVILPTPSVFEENFLSTLTSFIFFNKVEIVSMLQEDEKFLSEVFAQLTDEATDDDKRRELVNFFKEFCAFSQTLQPQNRDAFFKTLANLGILPALEIVMGMDDLQVRAAATDIFSYLVEFSPSMVREFVMQEAQQSDDDILLINVVIEQMICDSDPELGGAVQLMGLLRTLIDPENMLATANKTEKSEFLNFFYNHCMHVLTAPLLANTSEDKLEKDAVFGSIKTSTVCPDNYQTAQLLALILELLTFCVEHHTYHIKNYIMNKDLLRRVLILMNSKHTFLALCALRFMRRIIGLKDEFYNRYIIKGNLFDPVINALLDNGTRYNLLNSAIIELFEFIRVEDIKSLTSHIVENFYKALEPIEYVQTFKGLKTRYEQEKDRQSQKLSSVPSILRSNRFRRDARALEDDEELWFNEDDEEEGEAVVPPVEKTKPEDDFPEGYEKFLETKKAKELEDKENLPKRTSVGAFKFTFSHSVSAANGANSTNSKSVAAHTPPATSNGSSSKNTSLTTTVASTKGSLIGLVDYPDDEDEEEEEDASPRKRPRLGS
Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4).
Q7ZX60
Q0P5L5
SUMF1_BOVIN
Sulfatase-modifying factor 1
Bos
MAAPALGPARGCGAELTLVLLLSLFLLLGWAAGGEEAGPEAGAPSLVGSCGCGNPQRPGAQGSSAAAHRYSREANAPGSVPGGRPSPPTKMVPIPAGVFTMGTDDPQIKQDGEAPARRVAIDAFYMDAYEVSNAEFEKFVNSTGYLTEAEKFGDSFVFEGMLSEQVKSDIQQAVAAAPWWLPVKGANWRHPEGPDSTVLHRPDHPVLHVSWNDAVAYCTWAGKRLPTEAEWEYSCRGGLQNRLFPWGNKLQPKGQHYANIWQGEFPVTNTGEDGFRGTAPVDAFPPNGYGLYNIVGNAWEWTSDWWTVHHSAEETINPKGPPSGKDRVKKGGSYMCHKSYCYRYRCAARSQNTPDSSASNLGFRCAADHLPTTG
Oxidase that catalyzes the conversion of cysteine to 3-oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3-oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE.
Q0P5L5
P12312
PSBM_THEVL
Photosystem II reaction center protein M
Thermostichus
MEVNQLGFIATALFVLVPSVFLIILYVQTESQQKSS
One of the components of the core complex of photosystem II (PSII). PSII is a light-driven water:plastoquinone oxidoreductase that uses light energy to abstract electrons from H(2)O, generating O(2) and a proton gradient subsequently used for ATP formation. It consists of a core antenna complex that captures photons, and an electron transfer chain that converts photonic excitation into a charge separation . This subunit is found at the monomer-monomer interface. Probably involved in dimerization of PSII; at the monomer-monomer interface the only protein-protein contacts observed are between the 2 PsbM subunits. Lipids, chlorophylls and carotenoids contribute strongly to PSII dimerization.
P12312
Q03046
CEFD_AMYLA
Isopenicillin N epimerase
Amycolatopsis
MVATAWANAREQVSLDPAVTNLNAGSCGPLPRPVFDRVTVRARMAAGPMDFLSRQLPPLLWTARERLAGYLGARPERLAFATNVTGAVNLVASSVQPHLAAGGEILLSDQEYAPMRWCWERVARHQGLVVRTFRLPVQPLGSPDEVVEAATAAMGPRTRLLFFSHVVSSTGLVLPATRLCEEARRRGVLTVVDGAQAPGFTDLDLAALPCDYYAGSGHKWLLAPTGVGFLHFAEDQGGVLRPPQVSWGYRPDGENPSDERNRFGSTDRLRNLECEGTRDLCPWLAVPSAIDFQAGLGHGRVRERMRELAAFTRERLSGWRGLEPVTPAHPGLSGAMTAFRLPPGTDTAGLRHGLWDRFRIDVPVLDRPDGPLLRVSTHFYNTETEVERLAEALKELSK
Catalyzes the reversible isomerization between isopenicillin N and penicillin N.
Q03046
Q0RB94
PANC4_FRAAA
Pantoate-activating enzyme 4
Frankia
MLVRDRAELRAALVALDRAASSHPPAAAQDAGPARAASRHDRPVRAVVMTMGALHEGHASLLRAARARADQVVATIFVNPLQFGAGEDLDRYPRTLAADLAVCAREGVDVVFAPAVIHDPPPLVRFGAGPLGAVLEGASRPGHFDGMLTLVGTMLHLVQPDLAFFGRKDAQQLVCIRRMVADLAFDVTVIGVETAREPDGLARSSRNVYLTAEQRTEALALSRALAAGAAASADGAPAVLAAARAVLDAADGVDVDYLELAGPEDLGPVRGGPALLLVAARVGTTRLIDNVSLILPTDTQGA
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Q0RB94
Q99811
PRRX2_HUMAN
Paired-related homeobox protein 2
Homo
MDSAAAAFALDKPALGPGPPPPPPALGPGDCAQARKNFSVSHLLDLEEVAAAGRLAARPGARAEAREGAAREPSGGSSGSEAAPQDGECPSPGRGSAAKRKKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRVNLSEARVQVWFQNRRAKFRRNERAMLASRSASLLKSYSQEAAIEQPVAPRPTALSPDYLSWTASSPYSTVPPYSPGSSGPATPGVNMANSIASLRLKAKEFSLHHSQVPTVN
May play a role in the scarless healing of cutaneous wounds during the first two trimesters of development.
Q99811
Q5HW86
PYRF_CAMJR
OMP decarboxylase
Campylobacter
MKLCVALDLSTKEECLQLAKELKNLDIWLKVGLRAYLRDGFKFIEELKKVDDFKIFLDLKIHDIPNTMADACEEVSKLGVDMINIHASAGKIAIQEVMTRLSKFSKRPLVLAVSALTSFDEENFFSIYRQKIEEAVINFSKISYENGLDGMVCSVFESKKIKEHTSSNFLTLTPGIRPFGETSDDQKRVANLAMARENLSDYIVVGRPIYKNENPRAVCEKILNKIHRKNISENDIEQNYEVIQQKEWDMCNHFEEWIKTQPDKEHALKEFYAKCGIKY
Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).
Q5HW86
Q3AQF1
AROC_CHLCH
5-enolpyruvylshikimate-3-phosphate phospholyase
Chlorobium
MIQYVTAGESHGPALSAIVDGMPAGVPLTDEAINHQLARRQQGYGRGGRMKIETDKAEVLSGIRFGKTIGSPIAMVIRNRDWQNWTTTMAQFEQPQEAIPAITVPRPGHADLAGCIKYGFEDIRPVIERSSARETAARVAAGACAKLFLKALGIEIGSIVTAIGSAKEEMPQQELAAMLAHGAEAVATQADQSPVRMLSKSAETAAIAAIDEAKANGDTVGGIVDVFITGVPLGFGSYVQHNRRLDADLAAALLSIQAIKGVEIGTAFDNACKYGSQVHDEFIFSESGELTRPTNRAGGIEGSMSSGQVIHLRAAMKPISSLISPLQSFDIASMEPIPSRFERSDTCAVPAAGVVAEAVVAPVIANALLAKLGGDHFSEIHERLEAYRAYLANRLQRKS
Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
Q3AQF1
Q46WH5
ENGB_CUPPJ
Probable GTP-binding protein EngB
Cupriavidus
MSLLHQARFFTTVNHLRDLPATAVPEVAFAGRSNAGKSTAINILCNQKRLAFSSRTPGRTQHINYFTVAPVKAPDPIAFLVDLPGYGYAEVSGSAKYHWQGLLSDYVQTRSQLSGLILMMDARRPFTDLDCQMVEWFLPTGKPVHVLLTKADKLTNSENAKALRETRKMLEGYAEQLATPVPLTAQLFSSLKRRGIEEAQRVIAGWLSLPEAQAAAPAEQPAAPGASE
Necessary for normal cell division and for the maintenance of normal septation.
Q46WH5
B1HVP3
LGT_LYSSC
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
Lysinibacillus
MDLLLLQINPIAFHLGPIPVRWYGLLIVSGIILAYVVGQREAVKRGLPEDFLADLLLWAVPISIICARIYYVSMRWDYYSENPGKIIEIWNGGIAIHGALIGAFVTAYIFTRIKNVSFLRVADIAAPSILIGQIIGRWGNFMNQEAYGGPVSKEFLENLMLPDWIINQMYIEELGTYVHPTFLYESVWNLIGLIILLILRKVNLNRGEIFFSYLIWYSIGRFYIEGMRTDSLYLVGDLRSAQIVSIIGIVVGLGAIIYRRIKVKPAMKYLDNK
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
B1HVP3
A3N0G0
PCKA_ACTP2
Phosphoenolpyruvate carboxykinase (ATP)
Actinobacillus
MLSRIEQELAQLGITNVKEIVRNPSYEQLFEEEMKPELEGFEKGRLTTSGAVAVDTGIFTGRSPKDKYIVYDETSKDNVWWTSDAVKNDNKPMNQATWQSLKELVTHQLSNKRLFVVDAFCGANKDSRVAVRIVTEVAWQAHFVKNMFVRPSEEELLNFVPDFVVMNGSKVTNPNWKEQGLNSENFVAFNLTEKIQLIGGTWYGGEMKKGLFSLMNYWLPLKGIASMHCSANVGAEGDVAVFFGLSGTGKTTLSTDPKRKLIGDDEHGWDDDGVFNYEGGCYAKTINLSEENEPDIYRAIRRDALLENVVVREDGSVDFADGSKTENTRVSYPIHHIDNIVEPVSKAGHAKKVIFLTADAFGVLPPVSKLTPEQTKYYFLSGFTAKLAGTERGITEPTPTFSACFGAAFLSLHPTKYAEVLVKRMEEAGSQAYLVNTGWNGSGKRISIKDTRGIIDAILDGSIEKAETKELPIFNLAIPTALPNVDPAILDPRDTYADKAQWQTKAEDLAGRFVKNFEKYTTNDEGKALVAAGPKL
Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
A3N0G0
Q0TFD0
ACCD_ECOL5
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta
Escherichia
MSWIERIKSNITPTRKASIPEGVWTKCDSCGQVLYRAELERNLEVCPKCDHHMRMTARNRLHSLLDEGSLVELGSELEPKDVLKFRDSKKYKDRLASAQKETGEKDALVVMKGTLYGMPVVAAAFEFAFMGGSMGSVVGARFVRAVEQALEDNCPLICFSASGGARMQEALMSLMQMAKTSAALAKMQERGLPYISVLTDPTMGGVSASFAMLGDLNIAEPKALIGFAGPRVIEQTVREKLPPGFQRSEFLIEKGAIDMIIRRPEMRLKLASILAKLMNLPAPNPEAPREGVVVPPVPDQEPEA
Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.
Q0TFD0
P26310
COX6_DICDI
Cytochrome c oxidase polypeptide VI
Dictyostelium
MSTGNESYNLRYPKGFKGYPYNMYKLEGYGTPKGYITLIGVVATLTVSGLFFAKTRSNKREYPTHNKEWRAKTLAYAKETNADPIYQLPKDKI
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
P26310
B2UGP7
GLMM_RALPJ
Phosphoglucosamine mutase
Ralstonia
MSRKYFGTDGIRGRVGESPITPDFVLRLGYAAGRVLAHGGEAHGHGRPTVLIGKDTRLSGYMLEAALEAGFTAAGVDVLMSGPLPTPGVAYLTRALRLSAGVVISASHNPYYDNGIKFFSATGDKLPDETELQIEAELEKPMAYAASDALGRARRIEDAAGRYIEFCKSTFPSDLNLFGMKVVLDSAHGAAYHIAPHVFHELGADVVSIGNQPNGRNINDGYGATAPGKLVEATREHGADIGLAFDGDADRLQVVDRNGRLYNGDELLYVMVQARRAAGQTVPGAVGTLMTNLAVELALKAQGVEFVRAKVGDRYVLEELKKNGWLLGGEGSGHLLCLDKHSTGDGIISALQVLAALRRSGQTLDEMLDGVRLFPQKLINVRVEKGFDWKSHAGLQAALKTSEAELDGKGRVLIRPSGTEPVVRVMVEAQDAELANQHAERLAATLQ
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.
B2UGP7
Q8U3X9
NIKR_PYRFU
Putative nickel-responsive regulator
Pyrococcus
MGIVRFGVSIPKELLEKFDGIIEEMGYTNRSEAIRDLIRDMVVRHEWQLGDEEVAGTITIVYNHDEADVVRELLDLQHEYLNEIVSSLHVHMDEHNCLEVIVVKGRAKKIKKIADRLLSLKGVKHGKLVMTTTGRDIV
Transcriptional regulator.
Q8U3X9
Q83HU9
YQGF_TROW8
Putative pre-16S rRNA nuclease
Tropheryma
MVKSVADRFFLGLDFGSTRIGVARNCGSLAVPVGVLPRASCAEILGYISRYSIDEVVIGLPLTLAGKEKQSARLAKEFSRFLVSSGVQVRFFDERFTTVIATQKFYSLGKGVKQIRKCVDAAAATVMLQLFLDMEVKVDPLERKP
Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.
Q83HU9
Q0VQN0
ACP_ALCBS
Acyl carrier protein
Alcanivorax
MSSIEERVNKIIVEQLGVKPEDVKSEASFVEDLGADSLDTVELVMALEEEFETEIPDEEAEKISTVQSAVDYIKAHS
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Q0VQN0
Q2JK64
DXS_SYNJB
1-deoxyxylulose-5-phosphate synthase
unclassified Synechococcus
MHLSDITHPNQLRNLNLSQLRSLARQIRDKHLQTAANSPVGCHLGPGLGVVELTLALYKTLDLDRDKVIWDVGHQAYAHKMLTGRYHNFHTLRQKGGISGYLKRSESRFDHFGAGHASTSISAALGMAIARDRRGDNFKVVAIIGDGALTGGMAYEAINHAGHLPKTNLMVVLNDNGMSISPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLLGSSLSPEIDRLKETVKLVTAVQNNKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQVGYHAQSRFDLATGKPYPPTKPKPPSYSKVFGHALCKLAERDPRIIGITAAMDTGTGLDKLKEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRAYDQIIHDVCIQKLPVFFCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTQGPIAMRYPRGSGVGVPLAEEGWEPLPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISATVVNARFAKPLDTELILPLAEQSRLVVTVEEGCLMGGFGSAVAEALLDADLAVPLLRLGVPDVWVEHATPEESLAELGLNSAGIAERIRAKFQARVLKGSPAELPTVNS
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Q2JK64
B3QQE0
ISPH_CHLP8
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Chlorobaculum
MKINLDRTSSGFCIGVQGTIHVAEEKLNQSGELYCLGDVVHNEVEVKRLEALGMETIDIPAFEELRDAEVLIRAHGEPPSTYETARRNNLAITDTTCPVVAKLQKTAKMLHQLGYQVIIYGKKIHPEVIGINGQCNDEGVVIKHPDLSDEAEIAPLDLGRKTALISQTTMDVPGFYELKKNLEKLFAEHGHRNPGTKSGEWMAVRDIDITSEKTGGRAMPELVYKDTICRQVSSRNGKLRDFALANDCIVFAAGRKSSNGQVLYSICKDANPHSYFIEDVDEIQPEWFVGENGKPVESVGICGATSTPMWLLEKVANYIGKTFGDDSGNPDA
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
B3QQE0
A2XFP3
XXT1_ORYSI
Probable xyloglucan 6-xylosyltransferase 1
Oryza sativa
MWVAERVVGERRMREIQRFARNAKLTVVCLLLTVVVLRGTVGAGKFGTPQQDLIELRHRFISHPHRALAEHHDALSRGGGSSSSSGRAAQRDDEPDPPPRTLRDPPYTLGPKISDWDEQRAAWHRRHPETPPFVNDVKPRVLLVTGSSPKPCENPVGDHYLLKSIKNKMDYCRVHGLEIFYNMALLDAEMAGFWAKLPLLRALLLAHPEIEFLWWMDSDAMFSDMAFELPWERYGPYNLIMHGWDEMVYDDKNWIGLNTGSFLLRNCQWSLDFLDTWAPMGPKGPVRIEAGKVLTKYLKDRPVFEADDQSAMVYILATEREKWGDKVYLENGYYLHGYWGILVDRYEEMLENYHPGLGDHRWPLVTHFVGCKPCGKFGDYPVERCLKQMERAFNFGDNQILQMYGFTHKSLGSRKVKRIRNETSNPLDVKDELGLLHPAFKAMKTTST
Probable xyloglucan xylosyltransferase involved in the biosynthesis of xyloglucan in roots.
A2XFP3
A5ECI7
CH601_BRASB
Chaperonin-60 1
unclassified Bradyrhizobium
MAAKDVKFAGDARDRMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDKFENMGAQMLREVASKTNDLAGDGTTTATVLAQAIVREGAKAVAAGMNPMDLKRGIDTAVAAVIKDIEKRAKPVASSAEVAQVGTISANGDAAIGKMIAQAMQKVGNEGVITVEENKSLETEVDIVEGMKFDRGYLSPYFVTNAEKMTAELDDVYVLLHEKKLSGLQAMLPVLEAVVQSGRPLLIIAEDVEGEALATLVVNRLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQLISDDLGMKLENVTIKMLGRAKKVVIDKENTTIVNGAGKKADIEARVGQIKAQIEETTSDYDREKLQERLAKLAGGVAVIRVGGATEIEVKEKKDRVEDALNATRAAVQEGIVPGGGVALLRAKKAVGRITNPNSDVQAGINIVLKALEAPVRQIAENAGVEGSLVVGKILEEKSETFGFDAQSEDYVDMVAKGIIDPAKVVRTALQDASSVAGLLVTTEAMVAELPKEAAPAMPAGGGMGGMGGMGF
Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.
A5ECI7
Q67UI2
MUB2_ORYSJ
OsMUB2
Oryza sativa
MASGGGGGGGMEAVEVRFRLDDGSDIGPSMHDQATTVTALKEFVLARWPQGKEIAPRTVNDVTIINAGQVLENNRTLAESRNLAAESPEGPITMHVVVRRSRPERRVKQPPKARPPERIGCGCTIL
May serve as docking site to facilitate the association of other proteins to the plasma membrane.
Q67UI2
A4WGV2
RFCS1_PYRAR
Clamp loader small subunit 1
Pyrobaculum
MAELFWFEKYRPRSFDEVVDLEEVKARLREFVRGGNMPHLLFYGPPGTGKTTMALVLARELYGEYWRENTLELNASDERGINVIRERVKEFARTAPVGKAPFKLVILDEADNMTSDAQQALRRIMEMYAQNTRFILLANYVSRIIDPIISRCAVFRFSPMPRSLMAERLRHIAKSEGIELRDDAIDLIYEVSEGDMRKAINLLQVAAATSKVVDANAVASATTMIRPADVVELFNLAFNGDVTKAREKLRELMYVKGIAGIDFIRAFQRELIRMPLDDEVKAEIAELLAEVDYRLTQGSDEELQLLYLLSKLGAIGKRARQTPPPSKRR
Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA.
A4WGV2
Q823K6
DCD_CHLCV
Deoxycytidine triphosphate deaminase
Chlamydia
MSIKEDKWIRKMALAHGMIEPFADGQVNVDAETGEKLISYGLSSYGYDLRLSREFKVFTNVYNSLVDPKHFTEDTFISITDDVCIIPPNSFALAHSVEYFRIPRNILTMCIGKSTYARCGLIVNVTPFEPEWEGYVTIEISNTTPLPAKIYANEGIAQVLFFEADEMCEVSYAERKGKYQKQQGITVPFV
Catalyzes the deamination of dCTP to dUTP.
Q823K6
Q1CBU1
BTUB_YERPA
Outer membrane cobalamin translocator
Yersinia
MTIKKYTLLTALSVTAFSGWAQGNNTTDNNDEMVVTANRFPQPKSSVLAPVDVVTRADIDRWQSTNINDVLRRLPGVDIAQDGGMGQRSSLFIRGTNSSHVLVLIDGVRLNQAGITGASDLSQIPISLVQRIEYIRGPRSAVYGSDAIGGVINILTGRDKPGTTLSAGLGSNGYQTYDGSTQQKLGEDTTVTLAGNYTYSKGYDVVAGMPGAGGPRQPDRDGFMGKMLWAGLEHQFNEQFNGFARVYGFDNRSDYDGYTNYSNPLALIDTRKLSSRTYDTGLRYKNGIYASQFIASYNRTKDYNYSPLFGQHDITASLDEAEQYNLQWGNTFQLTNGMISAGADWQEQRTERKSSNQNTTADFTQHNTGIYLTGQQQISDVTLEGAVRSDDNSQFGWHSTWQTSAGWEFIDGYRLIGSYGTAYKAPNLMQLYSAYGGNANLKPEESKQWEGGVEGLTGPLTWRLSAYRNDIDQLIDYSNLTNGYFNINKATIKGVEWTGSFDTGPLSHQVTLEYLDPRNADTHEILVRRAKQQVKYQLDWQVADLDWSVTYQYLGQRYDKDYSTYPEETVELGGVSLWDLAVSYPVTSHLTVRGRIANLFDKDYEMVYGYQTPGREYYFTGSYNF
Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
Q1CBU1
Q6J1H4
UTF1_MOUSE
Undifferentiated embryonic cell transcription factor 1
Mus
MLLRPRRLPAFSPPSPASPDAELRSAGDVPVTTSDAFATSGGMAEPGSPKAPVSPDSAQRTPWSARETELLLGTLLQPAMWRSLLLDRRQTLPTYRRVSAALARQQVRRTPAQCRRRYKFLKDKLRDSQGQPSGPFDNQIRQLMGLLGDDGPPRVRRRSTGPGRPQRRGRSSLSALAPAPAPVEQEAELPLAAENDEPAPALRFSSSTTKSAGAHRITSSPPLTSTDTLPPEPGHTFESSPTPTPDHDVETPNEPPGLSQGRASSPQVAPQSLNTALLQTLTHLGDISTVLGPLRDQLSTLNQHVEHLRGSFDQTVSLAVGFILGSAASERGILGDLRQ
Acts as a transcriptional coactivator of ATF2.
Q6J1H4
Q8PPE2
NRDR_XANAC
Transcriptional repressor NrdR
Xanthomonas
MHCPFCQHNDTRVIDSRVSEDGTTIRRRRECEACGERFSTLETIELKLPTVVKSDGGREAFDARKLRTSFDRALQKRPVAEEQIEAAVRAVVHQLRMSGEREVGSLRVGEYVMVELRKLDHVGYVRFASVYRSFQDVADFREEIEKLERELPVGSEQLPLLEAALERAGKPGKR
Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.
Q8PPE2
C0ZJF8
NAGB_BREBN
Glucosamine-6-phosphate isomerase
Brevibacillus
MKLVIVKDYAELSRKAAEMLVSEVKANPKTVLGLATGGTPVGMYRELIKLSQAQSIDYSQASSFNLDEYVGLSSTHPQSYRSYMEENLFNHINIPAEKTHVPVGNTTDHLAECARYEEAIRLAGGIDIQVLGIGNNGHIGFNEPGSPADSLTRVVQLTDSTIEANARYFDSVEQVPTQAVSMGIKTILGAKKVVLLASGEAKAEAVRLMLEEEPTADVPASLLQLHRDVTVIVDQEAASKLTTSILAGTKPSGS
Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
C0ZJF8
B8CWL4
SYI_HALOH
Isoleucyl-tRNA synthetase
Halothermothrix
MDYKETINLPRTEFPMRANLSKREPGIEKYWEENNVYEKAIKNREGNKQFILHDGPPYANGDIHIGHALNKILKDIVTRYKTLSGYYSPYVPGWDTHGLPIEHKVTKEMGDKAKDLSVSELRDKCRDYALKYVERQKEQFKRLGVWGEWDKPYLTLNPEYEVKQIEVFGEMAKRGLFYKGKKPVHWCPSCETALAEAEVEYGEHRSPSIYVKFPLKDKVNVGGVELTPGDSYVVIWTTTPWTIPANMAIALHPEFDYVVVKASGEKLVMARELVDRVMEEAEVENYKVVGQAFKGTELENKRCRHPFEDRDSILILGDHVTLEQGTGCVHTAPGHGHDDYLVGLKYDLDIYAPMDNRGVFTEEAERFAGMYYDDVNKEVTKILDEKGLLMNLSFISHQYPHCWRCKGALIFRATDQWFASIEAIKEEALKAIHSVDWYPAWGEERMANMISERTDWCISRQKKWGVPIPVFYCKDCGHSIINDETIEAVKKLFAREGSSGWYKYSAEEILPEGFSCPECGGKSFKKEEDIMDVWFDSGSSHKAVLETRDHLSWPSQLYLEGTDQYRGWFNSSLLTAVATEGKPPYEAVVTNGFVVDDKGNKMSKSIGNVVSPQDVIKRYGADILRLWVASSNFKDDVRVSDRILKQNSEVYRRIRNTFRFILGNINDFNPGQHYVDYNDRAEIDRWIMIKLQDLIKDVTRAYDEYEYHRVYHDVHNFCTIEMSSLYVDIVKDRLYTDGTNSLSRRSAQSTLYDILLVLVKLVAPVLAHTAEEVWQHLDESSKDAESIFLTDWPEVVNEYYDDRLMSKWDKLLEVRKDVAKALELSRENKEIGNSLDARVILVPVDDKQRQLLKDNIDILPDLFIVSQVELQGETGEGFHKGSETGISVSVVKASGEKCARCWKYSEAVGNDEEHPELCERCVEVVRTEV
Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).
B8CWL4
Q9WTQ8
TIM23_MOUSE
Mitochondrial import inner membrane translocase subunit Tim23
Mus
MEGGGRSSNKSTSGLAGFFGAGGAGYSNADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEFILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQSMAWSKPRNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARGGLAGLTLTSLYALYNNWVHMKGSLLQQSL
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Q9WTQ8
B8IT33
RS13_METNO
30S ribosomal protein S13
Methylobacterium
MARIAGVNIPTNKRVVIALQYIHGIGPKKAEEITEKVGIPAERRVNQLTDAEVLQIREAIDRDYIVEGDLRREVAMNIKRLMDLGCYRGLRHRRNLPVRGQRTHTNARTRKGKAKPIAGKKK
Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.
B8IT33
Q1QTN9
FABV_CHRSD
Enoyl-[acyl-carrier-protein] reductase [NADH]
Chromohalobacter
MIIKPKVRGFICTTTHPLGCERNVAEQIATTRANIPESERDKGPKNVLVIGASSGYGLAARVTAAFGYGASTLGVFFEKPGTEKKPGTAGWYNAAAFDKFAKAEGLYSKAINGDAFSHEAREKAIELIKQDMGQIDLVVYSLASPVRKLPDSGELKRSALKPIGETYTATAIDTNKDAIVEASVEPATEEEIADTVTVMGGEDWELWVDALDKAGVLAPGARSVAFSYIGTEITWPIYWHGALGKAKEDLDRAAGELDARLGQHGGGANVAVLKSVVTQASAAIPVMPLYISMVYKVMKEQGLHEGTIDQLNRLYRERLYSTQGQNGELATDEAGRLRLDDWELRDDVQQACQDLWPQVTTENLFTLTDYAGYKREFLKLFGFERDDVDYEADVDPVAEFDVVQL
Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).
Q1QTN9
A1TJ08
RL4_ACIAC
50S ribosomal protein L4
Acidovorax
MQLELLNDQGQAASKIDVPETVFDRQYNEDLIHQIVVAYRANARQGTRAQKDREQVRHSTKKPFKQKGTGNARAGMTSSPLWRGGGRIFPNLPEENFTQKINKKMYRAGMASILSQLAREGRLAVVDSLKVETPKTKVLADKFKAMNLQSVMVISDEVDENLYLASRNLKNVFVVEPRYADPVSLVHYKKVLVTKGAIDKLKEMFA
Forms part of the polypeptide exit tunnel.
A1TJ08
Q8N8Y5
ZFP41_HUMAN
Zinc finger protein 41 homolog
Homo
MEKPAGRKKKTPTPREEADVQKSALREEKVSGDRKPPERPTVPRKPRTEPCLSPEDEEHVFDAFDASFKDDFEGVPVFIPFQRKKPYECSECGRIFKHKTDHIRHQRVHTGEKPFKCAQCGKAFRHSSDVTKHQRTHTGEKPFKCGECGKAFNCGSNLLKHQKTHTGEKPYECTHCGKAFAYSSCLIRHQKRHPRKKP
A putative DNA-binding regulatory protein associated with meiosis in spermatogenesis.
Q8N8Y5
Q756Q3
NPC2_ASHGO
Phosphatidylglycerol/phosphatidylinositol transfer protein
Eremothecium
MRVSVWYGLLHAAAWTRAVSLQVSEDSDEQWTVALRDSRPIPGGSPLSRCDLDEDHLLDVQEIEITPNPPHRGKNLTVEARGDLFGPVEDGAYVTVEVRLGYIKLLSETFDLCKELEENDLGLQCPLEEGEYELSKTVEIPQQVPPGRYHVVARAYTVDDEPITCLTGDVYFPPLMPAERSRMPRLIDPRRMRRLMDPRRKPRIMDEGSGAAA
Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.
Q756Q3
Q42395
FCP_TRICV
Fucoxanthin-chlorophyll a-c binding protein, chloroplastic
Trieres
MKLAIAALLAGSAAAFAPAQSGKASTALNMAFESELGAQPPLGFFDPLGMLADADQERFDRLRYVEVKHGRIAHVAFLGQIVTRNGIHLSGNIDYAGNSFDSFPNGWAAISGPDAIPQAGLLQIVAFVGILELAVMKDVTGEGEFPGDFRNGALDFGWDTFDEETKLSKRAIELNNGRAAMMGILGLMVHEQLGGSIPIVGEM
The light-harvesting complex (LHC) functions as a light receptor, it captures and delivers excitation energy to photosystems with which it is closely associated. Energy is transferred from the carotenoid and chlorophyll C (or B) to chlorophyll A and the photosynthetic reaction centers where it is used to synthesize ATP and reducing power.
Q42395
Q04087
LRS4_YEAST
Loss of rDNA silencing protein 4
Saccharomyces
MTTLLQLLSNYYKAKLDSERIYNEYVQSQYEFASLDKLNNNKGDPKKVVDETLFLQRQIAQLNKQLQLSFQENEKLLSVQKNQKALYQSKLSSKDAFIDDLKLKLKVEQISVDKHNKERTPSTGRDEQQRNSKAAHTSKPTIHLLSPIVNRDKPNNQTNDRGGNDPDSPTSQRRSRGLRSLLSSGKNTIFDSISKNLDDEINENAHIRNDTTSSKIAGKSPSRLSALQKSPELRKERNNMILKEHILRSKDDQNITSSRKLDNIELSSIGDSTAMTSRSSTVNANDILGNEENDGITKLKRVNKLTSSPVKRDCSTNKKRKLTKQRIATLPNSDEELSNNLNVDEFV
Component of the monopolin complex which promotes monoorientation during meiosis I, required for chromosome segregation during meiosis. Involved in rDNA silencing.
Q04087
A9MLY7
RECR_SALAR
Recombination protein RecR
Salmonella
MQTSPLLTQLMEALRCLPGVGPKSAQRMAFTLLQRDRSGGMRLAQALTRAMAEIGHCADCRTFTEQEVCNICANPRRQENGQICVVESPADIYAIEQTGQFSGRYFVLMGHLSPLDGIGPDDIGLDRLEQRLVSEKISELILATNPTVEGEATANYIAELCAQYGVEASRIAHGVPVGGELEMVDGTTLSHSLAGRHKIIL
May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.
A9MLY7
Q29429
IFNT6_SHEEP
Trophoblastin
Ovis
MAFVLSLLMALVLVSYGPGGSLGCYLSRKLMLDARENLRLLDRMNRLSPHSCLQDRKDFGLPQEMVEGDQLQKDQAFSVLYEMLQQSFNVFHTERSSAAWNTTLLEQLCTGLQQQLDHLDTCRGPVMGEKDSELGKMDPIVTVKKYFQGIHDYLQEKGYSDCAWEIVRVEMMRALTSSTTLQKRLTKTGGDLNSP
Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible.
Q29429
B8B406
MCM9_ORYSI
Minichromosome maintenance 9
Oryza sativa
MPPPAEEFAVDDLDEFESRLDSFLNRFHADDLRRILLPDPDGKLHFPLVIDFAELLEFDPEVAHQLYDYPKDVLELFDAAAQRALDKFDAAARRADKRKAGDEPMEKKFVHVRVNTSGSPLECPEASPSIGKVRVKHRGTLLTLKGTVIRSGGVKMIEGERKYQCRKCKCRFTVHPELEAGNRITLPASCKSKSAKGCGGANFQLIEDSITCHDYQEIKIQENIQLLGVGSIPRSMPIILMDDLVDIVKAGDDVVVTGRLSAKWSPDIKDVRSNLDPMLIANFVRRTNELKSDLDIPVEIINKFEEFWAASRATPLKGRNSILKGICPQIYGLFTVKLAVALTLIGGVQHVDASGTKVRGEPHMLLVGDPGTGKSQFLKFAAKLSNRSVITTGLGSTSAGLTVTAVKDGGEWMLEAGALVLADGGLCCIDEFDSMREHDRTTIHEAMEQQTISIAKAGLVTTLNTRTTVFGATNPKGQYDPNESLSVNTTLSGPLLSRFDIVLVLLDTKNKKWDKIVSSHILAENTEEKKGKTSDPEVMWTLSMLRRYIHYVKQHFKPVLTKEAERVISSYYQRQRQSGTRNAARTTVRMLESLIRLAQAHARLMFRNDVTKLDAIAAILCIESSMTTSAIVDTAGNALHSNFTENPDQECILKCDSIAYLSKNIKYLTDEISN
Probable DNA helicase that may play a role in DNA repair during meiosis.
B8B406
B3KYH4
TPA_PELSA
Temporin-1Sa
Pelophylax
FLGTINLSLCEQERDADEEERRDEPNESNVEVEKRFLSGIVGMLGKLFGK
Amphipathic alpha-helical antimicrobial peptide with highly potent activity against Gram-positive bacteria, and potent activity Gram-negative bacteria and fungi (MIC=2-30 uM) . Acts through membranolytic mechanism involving rapid membrane permeabilization and depolarization . Shows a direct extra-cellular antiviral activity probably through degradation of the viral envelope . Also shows a weak indirect antiviral activity by inhibiting virus replication . Also displays anti-trypanosoma and anti-leishmania (prosmastigotes and axenic amastigotes) activity through membranolytic mechanism . Also induces apoptosis in leishmania promastigotes at high peptide concentrations . Shows moderate hemolytic activity (LC(50)=25 uM) . In contrast to many antibiotics, this peptide does not induce bacterial resistance .
B3KYH4
Q57RH4
MODC_SALCH
Molybdenum import ATP-binding protein ModC
Salmonella
MLELNFSQTLGTHCLTLNETLPASGITAIFGVSGAGKTSLINAISGLTRPQKGRIALNGRVLHDAENGICLTPEKRRIGYVFQDARLFPHYKVRGNLRYGMAKSMTGQFDKLVSLLGIEALLDRLPGSLSGGEKQRVAIGRALLTAPELLLLDEPLASLDIPRKRELLPYLQRLAREINIPMLYVSHSLDEILHLADKVMVLEDGQVKAFGPLEEVWGSSVMHPWLPKEQQSSILKVSVLEHHPHYAMTALALGDQHLWVNKLNQPLQSTLRIRIQASDVSLVLQPPQQTSIRNVLRAKVANCYDDNGQVEVQLEIGGRTLWARISPWARDELNIKPGLWLYAQVKSVSITA
Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system.
Q57RH4
P23011
RBL_XANFL
Ribulose bisphosphate carboxylase large chain
Xanthobacter
MGADAAIGQIKDAKKRYAAGVLKYAQMGYWDGDYQPKDTDILALFRVTPQDGVDPVEAAAAVAGESSTATWTVVWTDRLTAADMYRAKAYKVEPVPGQPGQYFCWVAYELDLFEEGSIANLTASIIGNVFSFKPLKACRLEDMRLPVAYVKTFRGPPTGIVVERERLDKFGRPLLGATTKPKLGLSGKNYGRVVYEGLKGGLDFVKDDENINSQPFMHWRDRFLYCMEAVNKAQAETGEVKGHYLNITAGTMEEMYRRADFAKELGSVVVMVDLIVGWTAIQSISNWCRENDMLLHMHRAGHGTYTRQKGHGISFRVIAKWLRLAGVDHLHTGTAVGKLEGDPMTVQGYYNVCREDVTRTDYTRGIFFDQDWAGLRKVMPVASGGIHAGQMHQLIDLFGEDVVLQFGGGTIGHPDGIQAGAIANRVALETMILARNEGRDIKNEGPEILVEAAKWCQPLRAALDTWGEVTFNYASTDTSDFVPTASVA
RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.
P23011
Q1AXL8
ISPE_RUBXD
4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase
Rubrobacter
MRGSLRVRAFAKVNYALEVLGRRADGYHEIRTVLQSVSLWDELEISGPEGRFGLVVEPEGAGVGPERENTVYRAWRLLAGEAGAPPVRVTLRKGIPAGSGLGGGSADAAALLWGANELLGLGLGEADLAALALRVGADVPFCLVGGTALGEGVGERLFPLPAPPEHRLVVAMPPRGASTAEVYGAYGGLGGAAPGGWSGRVVRALRAGDLGALGAAVGNDLTPVTAGLAPEVEKLLAGLREAGALGACMSGTGSAVYGLFREEAAAHEAARRLGGAAFVRVCRPVGRGLAGG
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.
Q1AXL8
Q8L2F3
GRPE_MEIRU
HSP-70 cofactor
Meiothermus
MENNEPVVETPEAQNDLPEVERLKGEVEFLKAELEASKNKFLRLYADFENYKKRMVQELEAAQRNGKFDAVRALLGTLDDLERALGFASVKPEDLIPGVRSVLENFTRSLKSLGVEAVPGVGAEFDPRYHEAIGAVEGEEGKVMHVYQQGFKYGDLLVRPARVVVGSGAKPEEAEA
Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.
Q8L2F3
A5F3E6
DER_VIBC3
GTP-binding protein EngA
Vibrio
MVPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGQAKLGEHEFIVIDTGGIDGSEEGVETKMAQQSLAAIDEADVVLFMVDGRAGLTVADEAIAQHLRRIEKPAILVVNKVDGIDADAASAEFWQLGMDQMYQIAAAHGRGVGALIDRVLNPFAEQMESEQAQLEDLTNEEDPEEEQLEYSEEEAEAEYKRLQDLPIKLAIIGRPNVGKSTLTNRILGEERVVVYDMPGTTRDSIYIPMKRDEREYVLIDTAGVRRRKRINETVEKFSVVKTLQAIEDANVVLLVVDARENISDQDLSLLGFALNSGRSIVIAVNKWDGLSFDVKEHVKKELDRRLGFVDFARIHFISALHGTGVGHLFESVQEAYRSATTRVGTSVLTRIMKMATDDHQPPMVRGRRVKLKYAHAGGYNPPIIVIHGNQVNELPDSYKRYLMNYYRKSLEIMGTPIRIQFQNSENPFEGKTNKMTLSQERQRKRLMSMVKNRRK
GTPase that plays an essential role in the late steps of ribosome biogenesis.
A5F3E6
Q94JQ6
CESA6_ARATH
Protein QUILL
Arabidopsis
MNTGGRLIAGSHNRNEFVLINADENARIRSVQELSGQTCQICRDEIELTVDGEPFVACNECAFPVCRPCYEYERREGNQACPQCKTRFKRLKGSPRVEGDEEEDDIDDLDNEFEYGNNGIGFDQVSEGMSISRRNSGFPQSDLDSAPPGSQIPLLTYGDEDVEISSDRHALIVPPSLGGHGNRVHPVSLSDPTVAAHPRPMVPQKDLAVYGYGSVAWKDRMEEWKRKQNEKLQVVRHEGDPDFEDGDDADFPMMDEGRQPLSRKIPIKSSKINPYRMLIVLRLVILGLFFHYRILHPVKDAYALWLISVICEIWFAVSWVLDQFPKWYPIERETYLDRLSLRYEKEGKPSGLSPVDVFVSTVDPLKEPPLITANTVLSILAVDYPVDKVACYVSDDGAAMLTFEALSETAEFARKWVPFCKKYCIEPRAPEWYFCHKMDYLKNKVHPAFVRERRAMKRDYEEFKVKINALVATAQKVPEDGWTMQDGTPWPGNSVRDHPGMIQVFLGSDGVRDVENNELPRLVYVSREKRPGFDHHKKAGAMNSLIRVSGVLSNAPYLLNVDCDHYINNSKALREAMCFMMDPQSGKKICYVQFPQRFDGIDRHDRYSNRNVVFFDINMKGLDGLQGPIYVGTGCVFRRQALYGFDAPKKKKGPRKTCNCWPKWCLLCFGSRKNRKAKTVAADKKKKNREASKQIHALENIEEGRVTKGSNVEQSTEAMQMKLEKKFGQSPVFVASARMENGGMARNASPACLLKEAIQVISCGYEDKTEWGKEIGWIYGSVTEDILTGFKMHSHGWRSVYCTPKLAAFKGSAPINLSDRLHQVLRWALGSVEIFLSRHCPIWYGYGGGLKWLERLSYINSVVYPWTSLPLIVYCSLPAICLLTGKFIVPEISNYASILFMALFSSIAITGILEMQWGKVGIDDWWRNEQFWVIGGVSAHLFALFQGLLKVLAGVDTNFTVTSKAADDGEFSDLYLFKWTSLLIPPMTLLIINVIGVIVGVSDAISNGYDSWGPLFGRLFFALWVIIHLYPFLKGLLGKQDRMPTIIVVWSILLASILTLLWVRVNPFVAKGGPILEICGLDCL
Catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation. Involved in the primary cell wall formation. The presence of each protein CESA1 and CESA6 is critical for cell expansion. The hypocotyl elongation is based on a CESA6-dependent cell elongation in dark and a CESA6-independent cell elongation in light. The transition between these two mechanisms requires photosynthesis and PHYB, but not CRY1. The CESA6-dependent cell elongation seems to be independent of gibberellic acid, auxin and ethylene. May be involved in sensitivity to isoxaben. Associates with and moves along cortical microtubules for the process of cellulose deposition.
Q94JQ6
Q2W4W1
ZNUC_MAGSA
Zinc import ATP-binding protein ZnuC
Magnetospirillum
MSLLNLSGVRLSHGGHLVLDRVDLTVDAGRIITVVGPNGAGKSSLLKVALGLLRPDAGTVERGAKVIGYVPQRLDIGRLLPLSVRRFLAMAVAERPPAGRLEETLDLVGAGHVLGRQVVDLSGGEMQRVLLARALLRRPDLLVLDEPVGGVDVAGQAELYDLITGQAREHGVGVLMVSHDLHVVMAATDHVVCLNRHVCCAGHPETVSRHPEYLALFGPRVAASLAIYTHAHDHGHGADGSVLPLAEGGGEPHTHGPGCRHG
Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system.
Q2W4W1
A7HI47
MURA_ANADF
UDP-N-acetylglucosamine enolpyruvyl transferase
unclassified Anaeromyxobacter
MDKIVIDGGVPLRGSVATSGAKNAALPIIAGALLAEGDHLVRNVPDLADVRTLGRLLVHMGCQAERNAGEKGALWIRVPAAVQPEAPYELVKTMRASVVVLGPLVARWGKARVSLPGGCAIGARPIDQHLKGLSALGAEIRLEHGYVEATAPRGRLRGATFTFDAQTVTGTENVMMAAALAEGETLLRNCAREPEIVDLAAALVRMGARISGAGADEIRIEGVETLRPLDHVVIADRIEAGTFLAAGALPGNDVTVQGCVLEHVEALVEKLRAAGAEVLPVDGGLRVVGDGRPRPVDVRTAPHPGFPTDMQAQMMALLCLADGSSKITETVFENRFMHVQELQRLGAEIAVDGKTAVVKGVPELSGAPVMASDLRASAALVLAGLAAQGTTEVHRVYHLDRGYERIEEKLAPLGARIRREKA
Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.
A7HI47
Q55DL0
DPYS_DICDI
Hydantoinase
Dictyostelium
MLRVDQTGTILIKNGTVVNDDRYFKSDVLVENGIIKEISKNIEPKEGIKVVDATDKLLLPGGIDTHTHFQLPFMGTVSVDDFDIGTQAAVAGGTTFIIDFVIPTRGQSLLEAYDQWKKWADEKVNCDYSLHVAITWWSEQVSREMEILVKERGVNSFKCFMAYKNSFMVTDQEMYHIFKRCKELGAIAQVHAENGDMVFEGQKKMLEMGITGPEGHELSRPEALEAEATNRAIVIADSVCTPVYIVHVQSIGAADVICKHRKEGVRVYGEPIAAGLGVDGSHMWNHDWRHAAAFVMGPPIRPDPRTKGVLMDYLARGDLDCVGTDNCTFCADQKAMGKDDFTKIPNGVNGVEDRMSIVWENGVNTGKLTWCQFVRATSSEAARIFNIYPRKGRIDVGCDGDIVIWDPNQSKTISKDTHHHAVDFNIFEGIKVTGIAVTTIVAGNIVWSDNKLSCVKGSGRFVPRPPFGPVFDGIEQRDKVRNELLRKVDRKPYEDDNTKNSSK
Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
Q55DL0
Q5QJC9
BAG5_RAT
Bcl-2-associated athanogene 5
Rattus
MDMGNQHPSISRLQEIQREVKSIEQQVVGFSGLSDDKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQDTERLLKELEQNANHPHRIEIKNIFQEAQALVKEKTVPFYSGSNCVTSEFEEAIQDIILRLTHVKTGGKISLRKARYHTLTKICAVQEIIEDCVRKQPSLPLSEDVHPSVAKINSVMCEVNKARGTLIALLMGVDSSETCRHLSCVLSGLMADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEEEADNTHAFDLGQNHSIIKIENVLKRMREMKNELLQAQSPPELYLRSKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYLDLKEALEKRKLFPCEETPPHKAVWNVLGNLSEIQGEVLSFGGNRTDKNYIRLEELLTKQLLTLDAVDPLGEEKCKAARKQAVKLAQNILSYLDMKSDEWEY
May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN.
Q5QJC9
Q8X6X7
NUDC_ECO57
NADH pyrophosphatase
Escherichia
MDRIIEKLDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLIQQQRRYDMGSVRQVIDLDVGLFQLAGRGVQLAEFYRSHKYCGYCGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKHLRYVTSQPWPFPQSLMTAFMAEYDSGDIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCRAEYE
mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates.
Q8X6X7
Q0BYD8
RPOA_HYPNA
Transcriptase subunit alpha
Hyphomonas
MTTVNDRNWKVLIRPNRPVVQAGYDAKRKAKLVVEPLERGYGTTLGNALRRVLLSSLQGAAIIGVQIDGVVHEFSAIPGVREDVTTIVLNLKQVAIFMESDTPKRMVLRAKGPGEVKAGQIETPGDVKILNPDLVICTLDGGSEVRMEFTVATGKGYVAAEAHRPEDAPIGYIPIDAIYSPVRRVGYQVEDTREGTVLDYDKLTLDIETDGSLSPEDSVAYAARILQDQLQLFINFEEPTLETGGAADETDLGFNPVLLKKVDELELSVRSANCLKNDNIVYIGDLIQKSEAEMLRTPNFGRKSLNEIKEVLAGMGLHLGMEVPDWPPEDIEGLAKKYDDHI
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
Q0BYD8
Q3K3U8
KAD_STRA1
Adenylate monophosphate kinase
Streptococcus
MNLLIMGLPGAGKGTQAAKIVEEFGVAHISTGDMFRAAMANQTEMGRLAKSYIDKGELVPDEVTNGIVKERLAEDDIAEKGFLLDGYPRTIEQAHALDATLEELGLRLDGVINIKVDPSCLIERLSGRIINRKTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNIAQGESILEHYRKLGLVTDIEGNQEITEVFADVEKALLELK
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Q3K3U8
A8FRM9
TRMN6_SHESH
tRNA m6A37 methyltransferase
Shewanella
MAFTFKQFHIDDFGCGMPVSTDAVILGAWAPLSDAQNILDIGAGSGLLSLMATQRSNAKVTSIELDDTAVNACQKNFEASPWTSRLTVKHSSVQEFSKQHQESEESLFDHIICNPPYFKGGTQSQNRLRAQARHTDTLDFCALLEAIGSLLAPNGTASLILPSQSMSEFGLVLADSSLEFSQVTDISDSQRKTPHRHLFTLCHKSTDASAKPNEGATEHFCIKELDGSYTEEMKLLITGFYLKY
Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC).
A8FRM9
D1C4U5
FTSH3_SPHTD
ATP-dependent zinc metalloprotease FtsH 3
Sphaerobacter
MNPRPVRPGGSLQQSLLALGSLSVAVGLAVWQQRTLGRGRSDSVTAVERPETTFSDVAGLIEAKEELAEIVTFLRDPERFRRMGARMPRGVLLAGPPGTGKTLLARAVAGEAGVPFFAMSASQFVEVYVGVGAKRVRDLFAAARKASPAIVFIDEIDAIGRRRGDSQSHQEYEQTLNQVLVELDGFHPRQAVVVIAATNRSDILDPALLRPGRFDRRVELSLPDRAERAAILRVHAQDKPLAPDVDLDALAARTVGLSGADLENTLNEAALLALRRGGDEITQADLEEAVDRVIAGPSRRSRALSARERETIAVHEAGHALVAHQLASADAPRRVTILGRGQMGGATVLAPDEDRRLWTRGQFLDRLAVLLGGYAAEEYRYGEVTTGSSGDLSQASALAQAMVTTYGMGKSLRGRAFDANGPVSDETSRAIDEEVSALVSEALELASRTIANAAHLLDALVAALLAEETLDEARLAAILGPRPARPAMN
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.
D1C4U5
Q9I273
SSTT_PSEAE
Na(+)/serine-threonine symporter
Pseudomonas
MTYPERPLLHLLTRTSLVGQIIVGLIAGLLLASFFPAAALKVGFIGKVFVSALKAVAPVLVFVLVMASIANHKQGQQTHIRPILLLYLVGTFSAAVVAVIASFAFPSSLVLASHPGEMSPPGGIAEVLQSLLLSVVDNPVNALISANFIGILAWAIGLGIAFRHASDTTRNLLSELSNGVSLIVKVVIRFAPLGIFGLVASTFAESGVEALKGYAHLLVVLLGCMLFVAFVVNPLIVFLKIRRNPYPLVLTCLRESGMTAFFTRSSAANIPVNLQLCERLGLHEDTYSVSIPLGATINMAGAAITITVLTLAAVHTLGIAVDVPTAILLSVVASICACGASGVAGGSLLLIPLACSLFGIPSEVAMQVVAVGFIIAILQDSAETALNSSTDVLFTAAACEAEERKASAA
Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
Q9I273
A5V9Q2
TRMD_RHIWR
tRNA [GM37] methyltransferase
Rhizorhabdus
MTFAATILTLYPEMFPGPLGVSLAGRALAEGKWSCDPVQIRDFATDRHRSVDDTPAGGGAGMVMRADVLARAVDHALETRPDSPLLAMTPRGAPLTQARVRQLAAGPGVTILCGRFEGIDERLFEARPIEPVSIGDYILSGGEMGALVLLDACIRLLPGVMGAPDSGDEESFESGLLEYPHYTRPAEWEGRTIPEVLRSGDHARIEAWRNAMAETDTRLRRPDLWERHEGARAQSPSGARRQKKER
Specifically methylates guanosine-37 in various tRNAs.
A5V9Q2
Q52665
BZTC_RHOCB
Glutamate/glutamine/aspartate/asparagine transport system permease protein BztC
Rhodobacter
MSDTSFVRTEMLAPRPAPVSQVGAIKWMRENLFSGPLNTALTVFGLLATVWLVQAAAPWLLHGVWNANSLTECRAIIAERWGPEATGACWAVIRVRWNQFLFGFYPVDQYWRLFVTFAGLFLALAPVLFDALPRKLIWGTLLYPLAAFWLLWGGPIWGPVSVLAGFAILGLLFTALAPKLGVPVSAGIGLVVAALFWLYAAAPIEAALQSALPLALPEVDSDQFGGFLLALVIGVTAIVVSLPLGILLALGRQSDMLIVKSLSVGIIEFVRGVPLITLLFTASLLLQYFLPPGTNFDLILRVVILVTLFAAAYIAEVIRGGLAALPRGQYEAADALGLDYWQAQRLIIMPQALKISIPGIVSSFIGLFKDTTLVAFVGLFDPLKGISNVVRSDMAWKGTYWEPYIFVALIFFLFNFSMSRYSMYLERKLKRDHR
Part of a binding-protein-dependent transport system for glutamate, glutamine, aspartate and asparagine. Probably responsible for the translocation of the substrate across the membrane.
Q52665
Q9ERI2
RB27A_MOUSE
Ras-related protein Rab-27A
Mus
MSDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRANGPDGAVGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQRAVKEEEARELAEKYGIPYFETSAANGTNISHAIEMLLDLIMKRMERCVDKSWIPEGVVRSNGHTSADQLSEEKEKGLCGC
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
Q9ERI2
O29164
ACDE1_ARCFU
ACDS complex carbon monoxide dehydrogenase subunit epsilon 1
Archaeoglobus
MMEMAVAKEEKFPTAKRFDIADIQVSREATAVKPKVVANMIKRAKRPLLVTGGQLLKDEKLVEFAVKFAEKGIPIAATAGSSKPLIERGIKPVSKTYTLHQITQFLQDEEFQGFDGNGNYDTVIFLGFLPYYLSRMLSSLKHFSKITTIAIDEFYQPHAKFSFTNLTKDRELYYSMLQEVLDNL
Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD-mediated CO oxidation.
O29164
Q6GDE0
CAPA_STAAR
Capsular polysaccharide biosynthesis protein CapA
Staphylococcus
MKEKFDLVKLLNILKKNIKLLLILPAICLVVSAALTFFVMPDKYTASTQILVNMKKSSSDLAFQNVQSSLQSVNTYTEIIKSPRILDKVSREFDGQYSTAELNSFLKVTNQTNSQIITVSVTTGNKSESDKIVNRISKVFAHDMPKIMSVDNVTILSSAHDNAVKVSPIVSVNLVISIIVGIVLAILIIFLKELLDKRIKTEEDVESQLGLPILGSIQKF
Required for the biosynthesis of type 1 capsular polysaccharide.
Q6GDE0
P06642
HBE2_BOVIN
Hemoglobin epsilon-2 chain
Bos
MVHFTTEENVAVASLWAKVNVEVVGGESLARLLIVCPWTQRFFDSFGNLYSESAIMGNPKVKVYGRKVLNSFGNAIKHMDDLKGTFADLSELHCDKLHVDPENFRLLGNMILIVLATHFSKEFTPQMQAAWQKLTNAVANALTHKYH
Hemoglobin epsilon chain is a beta-type chain found in early embryos.
P06642
Q9PP04
AMPA_CAMJE
Leucyl aminopeptidase
Campylobacter
MKFELNDKKLDAIKADFELVFIQDKNLKIFNKEKDFFKLNNYKGEGALLDLNNKKLYLELKSLAYEDIRLSLCTAYKTLEKLNIKSVKLPSIIGDCVVRSFASLVEGVLFGAYKFDKYKSEKKTSTLEKFIISNEELNGKKFNKDEAKIGLERGEILANATNFTKNIVNEIPEIYTPLKMAEDAQNLAKENKNIICKIYDEKFLAKEKMNAFLAVNHASVHPPRLIHLSYKAKNAKKRVVFVGKGLTYDSGGLSLKPADFMLTMKADKSGAAAAMGIIKAVAELALDLEVHCILGATENMIGGNAYKPDDVLISREGVSIEVRNTDAEGRLVLADCLSFAQDLKPDLLIDMATLTGACVVGLGEFTSAIMGNNEELQNDFYLSSKKSGEYTTILHFNPHLRELIKSNIADVSNTASSRYGGAITAGLFLDKFIRKEYKDKWLHLDIAGPAYTEKSWGYSSFGAGGAGVRMCVNYLIQILRKAK
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Q9PP04
B1GYL7
ENO_ENDTX
2-phosphoglycerate dehydratase
Endomicrobium
MAKIVKIAGREIIDSRGNPTVEVDVRLGDGTLGRAAVPSGASTGSREALELRDGDKKRFGGKGVLKAVSNVNDIIAPKLTGLEITKQQDIDDIMIKLDGTDFKSSLGANAVLGVSLACAKAGSNSNKLPVYEYVREIYNVKSDKYVLPVPLMNIINGGEHADNNVDLQEFMIAPVSAPTFREALRMGCEVFHGLKKVLNEKGYATGVGDEGGFAPNLKSNAQALEVICEAVKVAGYEVGRDIVFALDVAASELYENNKYTLEGEVKEKVKTSKDMIAFYGDLLKEYPIISIEDGLSESDWDGWKILTEKLKSRLQLVGDDLFVTNTKIFKDGIDKGIANSILIKVNQIGSLSETVAAVQMAYKAGYTAVMSHRSGETEDSIIADLAVALNTGQIKTGSASRTDRMCKYNQLLRIEEELGSKSAYLGKSAFSSIK
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
B1GYL7
K4CJJ1
NCED2_SOLLC
Nine-cis-epoxycarotenoid dioxygenase 2
Solanum subgen. Lycopersicon
MTSTIANYRVSHSFSPSTSYSLDFTLPSKSISMKNHTTTKTKIHSALLTLPKQNNTPKNQPQFQTSHWNFFQKAAAKALDIVESALVSRELQNPLPKTADPRVQIAGNFAPVPEQSVRHNLPVTGTIPDCINGVYVRNGANPLFEPVAGHHLFDGDGMVHAVTVENGSVSYSCRFTETERLVQERELGHPVFPKAIGELHGHSGIARLLLFYARGVFGLVDHSHGTGVANAGLVFFNNRLLAMSEDDVPYHVQVLPSGDLQTVGRYNFDDQLKSTMIAHPKIDPVSGELFALSYDVVQKPYLKSFKFSPDGEKSPDVEIPLDVPTMMHDFAITENYVVIPDQQVVFKLQEMIKGGSPVIYDKNKKSRFGILPKNAENSENIIWVESAETFCFHLWNAWEEPETDEVIVIGSCMTPPDSIFNECNENLKSVLSEIRLNLKTGESTRRQLLSPSDQVNLEAGMVNRNKLGRKTQFAYLAIAEPWPKVSGFAKVDLSTGEIKKHIYGDKRYGGEPLFLPRNVNSEKEDDGYILAFCHDEKTWKSELQIVNAMTLELEATVKLPSRVPYGFHGTFISSKDLQNQV
Has a 11,12(11',12') 9-cis epoxycarotenoid cleavage activity. Catalyzes the first step of abscisic-acid (ABA) biosynthesis from carotenoids.
K4CJJ1
Q2T1P5
ACEK_BURTA
Isocitrate dehydrogenase kinase/phosphatase
pseudomallei group
MNHFPKLLSSQIGFDVAQTILENFDRHYRIFREAAVEAKDLFERSDWHGLQRLARERITSYDDRVRECVELLEDEYDAENIDHDVWPQIKLHYIGLLTSHRQPECAETFFNSVCCKILHRAYFNNDFIFVRPAISTEYIENDEPAAKPTYRAYYPGSEGLAATLERIVTNFQLNPPFEDLERDIACIMQAIHDEFGAFDEAVNFQIHVLSSLFYRNKTAYIVGRIINGDRVLPFAVPIRHARAGVLALDTVLLRRDQLKIIFSFSHSYFLVDMNVPSAYVQFLRSIMPGKPKAEIYTSVGLQKQGKNLFYRDLLHHLSHSSDRFIIAPGIKGLVMLVFTLPSFPYVFKMIKDHFPPPKETTREQIMDKYLLVKRHDRLGRMADTLEYSSVALPLARLDDALVRELEKEVPSLIEYEGDSLVIKHLYIERRMVPLNLYLQNGSDAEIEHGVREYGNAVKELIQANIFPGDMLYKNFGVTRHGRVVFYDYDEIEYLTDCNVRRVPPPRNDEDEMSGEPWYTVGPHDIFPETYAPFLLGDPRVREHFLAHHADFFDPQLWQDSKDRLLRGELPDFFAYEPALRFCLRYPERFAPGDAAEDGKRAAA
Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
Q2T1P5
Q9SNC6
PUB13_ARATH
RING-type E3 ubiquitin transferase PUB13
Arabidopsis
MEEEKASAAQSLIDVVNEIAAISDYRITVKKLCYNLARRLKLLVPMFEEIRESNEPISEDTLKTLMNLKEAMCSAKDYLKFCSQGSKIYLVMEREQVTSKLMEVSVKLEQSLSQIPYEELDISDEVREQVELVLSQFRRAKGRVDVSDDELYEDLQSLCNKSSDVDAYQPVLERVAKKLHLMEIPDLAQESVALHEMVASSGGDVGENIEEMAMVLKMIKDFVQTEDDNGEEQKVGVNSRSNGQTSTAASQKIPVIPDDFRCPISLEMMRDPVIVSSGQTYERTCIEKWIEGGHSTCPKTQQALTSTTLTPNYVLRSLIAQWCEANDIEPPKPPSSLRPRKVSSFSSPAEANKIEDLMWRLAYGNPEDQRSAAGEIRLLAKRNADNRVAIAEAGAIPLLVGLLSTPDSRIQEHSVTALLNLSICENNKGAIVSAGAIPGIVQVLKKGSMEARENAAATLFSLSVIDENKVTIGALGAIPPLVVLLNEGTQRGKKDAATALFNLCIYQGNKGKAIRAGVIPTLTRLLTEPGSGMVDEALAILAILSSHPEGKAIIGSSDAVPSLVEFIRTGSPRNRENAAAVLVHLCSGDPQHLVEAQKLGLMGPLIDLAGNGTDRGKRKAAQLLERISRLAEQQKETAVSQPEEEAEPTHPESTTEAADT
Functions as an E3 ubiquitin ligase.
Q9SNC6
Q48L73
MINC_PSE14
Probable septum site-determining protein MinC
Pseudomonas
MSQIESQNPEPVFQLKGSMLAITVMELARTNLEALDRQLAAKVAQAPNFFSNTPLILALDKLAPNEGPVDLPGLVRICRQHGLRTLAIRANRIEDIAAAIAVDLPVLPPSGARERVIDPIEVEAPKKIPEKPPEPLIKPTRVITAPVRGGQQIYAQGGDLVVVAPVSPGAELLADGNIHVYGPMRGRALAGIKGDTKARIFCQQLSAELISIAGQYKVSEDLRRDPLWGSPVQVSLSGDVLNIIRL
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
Q48L73
Q12ZU6
RL22_METBU
50S ribosomal protein L22
Methanococcoides
MARIKYTTELDAETSAKAMGSELHISPKKSRELCKAIKGMRTNAARQYLEDVVILKQAVPFGRHNDSLGHRKGPMAAGRYPVKVASEMLKLLKNAESNAEYKGLNPEHMFIAHTAMNRGRVIHGMRPRARGRASPENTETVNLEMIISEVR
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.
Q12ZU6
B3DRN8
PAFA_BIFLD
Pup-conjugating enzyme
Bifidobacterium
MPQLRDSGTRSLHATEPVPSAEMDGFCRIFGVETEYGVAVTGAERPVDAGQVAMTMFQPIVSRSRSTNTYLTNGSRLYLDVGSHPEYATAEARDPREALAQDLAGEHVMRNLALKAQRKLRESYGAHATIHVFKNNVDSAGHAFGCHENYLVRRFVPLETIEHQLLPFLITRQLYTGAGRMTPDGFQITQRADFLDEAVSSATTRSRPMVNTRDEPHADPDSFRRLHVIIGDSNRSQWSTWMKLAVTHLVLCAIEDAFRHGTPSGFEHCAFADPAAANRTVSRFLDDPHAELTLESGESVSALGLQRRYYAAVKAFIETHVDALASSLPATTIDTIMGEWSRVLDALERGAYDALADRVDWAAKKRLFDALKRRRPDVTFAQMEQLELDYHDIANGRLYGSLVARNQMRELLTGDNVEYAVHNPPTDTRAALRGRFVDAALNVGAQFSADWTHLTLTAPERREAILLDPFEAEPTLGFEQLMEALN
Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.
B3DRN8
Q489T8
RL9_COLP3
50S ribosomal protein L9
Colwellia
MEVILLDKIAKLGGLGDKVSVKSGYARNYLLPQGKAVFASEANVEHFEARRADIEAKLADVLATAEARAAKVVALAEVTIASKSGDEGKLFGSIGTRDIADAITEAGVEITKAEVRLPLGAIRETGEFEIAIHLHHDVDTSIKVVVIAEA
Binds to the 23S rRNA.
Q489T8
Q6B8U6
PSAA_GRATL
PsaA
Agarophyton tenuistipitatum
MTISSQEQETKKVQVTVDKNPVATSFEKWAKPGHFSRTLAKGPKTTTWIWNLHADAHDFDSHTSSLEEVSRKIFSAHFGQLAIIFLWLSGMYFHGAKFSNYIAWLSNPTAIKPSAQIVWPIVGQEILNGDVGGGFQGVQITSGFFQIWRASGITTEFELYATAIGGLFMACLMLFAGWFHYHKAAPKLEWFQNVESMMNHHLAGLLGLGCLGWAGHQIHISIPINKLLDSGVSPQELPLPHEFLVNRELVSQLYPSFSKGIIPFFTLNWNEYSDFLTFKGGLNPITGGLWLTDTAHHHLALAVLFLVAGHMYRTNWGIGHSMKEILEAHKGPFTGEGHKGIYEILTTSWHAQLAINLAMMGSLSIIVAHHMYAMPPYPYIATDYPTQLSLFTHHMWIGGFCIVGAGAHASIFMVRDYNPAQNYNNVLDRVIRHRDAIISHLNWVCIFLGFHSFGLYIHNDTMRALGRSQDMFSDTAIQLQPIFAQWIQNIHSLAPSNTSPNALATASYAFGGDVIAVNNKIAMMPINLGTADFMVHHIHAFTIHVTVLILVKGFLFSRNSRLIPDKSSLGFRFPCDGPGRGGTCQVSGWDHVFLGLFWMYNSLSIAIFHFSWKMQSDVWGSVTPAGTVSHITGGNFAQSAITINGWLRDFLWAQASQVIQSYGSALSAYGLIFLGAHFVWAFSLMFLFSGRGYWQELIESIVWAHNKVKVAPSIQPRALSITQGRAVGVAHYLLGGIGTTWAFFLARIISVG
PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin/cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6.
Q6B8U6
Q8XCJ6
G6PD_ECO57
Glucose-6-phosphate 1-dehydrogenase
Escherichia
MAVTQTAQVCDLVIFGAKGDLARRKLLPSLYQLEKAGQLNPDTRIIGVGRADWDKAAYTKVVREALETFMKETIDEGLWDTLSARLDFCNLDVNDTAAFSRLGAMLDQKNRITINYFAMPPSTFGAICKGLGEAKLNAKPARVVMEKPLGTSLATSQEINDQVGEYFEECQVYRIDHYLGKETVLNLLALRFANSLFVNNWDNRTIDHVEITVAEEVGIEGRWGYFDKAGQMRDMIQNHLLQILCMIAMSPPSDLSADSIRDEKVKVLKSLRRIDRSNVREKTVRGQYTAGFAQGKKVPGYLEEEGANKSSNTETFVAIRVDIDNWRWAGVPFYLRTGKRLPTKCSEVVVYFKTPELNLFKESWQDLPQNKLTIRLQPDEGVDIQVLNKVPGLDHKHNLQITKLDLSYSETFNQTHLADAYERLLLETMRGIQALFVRRDEVEEAWKWVDSITEAWAMDNDAPKPYQAGTWGPVASVAMITRDGRSWNEFE
Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.
Q8XCJ6
B9M6F7
KAD_GEODF
Adenylate monophosphate kinase
Geotalea
MNLILLGPPGAGKGTQAKLLIKKYRIPQISTGDILRAAVKDMTPMGGKAKSFMDAGALVPDEVVVGIIQERLNLADCSNGFILDGFPRTVAQADALAKVLSGLGRSIDHVISIVVDNEELLERVTGRRTCRNCGKGFHVSFDPPKSSGICDECSGELYQRDDDREDTMRKRLEVYWQQTSPLVEYYKNKSLLRSVEGVGSMEEIQQKIVSILQG
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
B9M6F7
Q7VHX2
TGT_HELHP
tRNA-guanine transglycosylase
Helicobacter
MQVTLQAQDGGARALSLKLAHSEVQTPVFMPVGTQGCVKALDSRDMSEILNAQIILVNTYHMYLRIGIERLKNFGGIARFAHFDRSYLSDSGGFQAFSLNKNAKVTNEGVAFKSHIDGSKHFFSPEYVLDIQYALNSDIMMVLDDLVGLPSSEERIADSIARTSDWAQKSLIYHQSQKARGLGLNNNLFAIIQGGVNEHFRTLCAKQLVDMGDFDGFAIGGLAVGETSEQMYKTISFTTPLMPVNKPRYLMGVGTPENIIESIALGVDMFDCVMPTRNARNATLFTHFGKINIKAAIFSNDQSPIDELCDCYTCQHFTRAYLCHLFRSQEMTYYRLASLHNLHYYLNLMREAREAILQGTFSAYRSSFYALREMEIPNNEY
Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).
Q7VHX2
Q6C101
CD123_YARLI
Cell division cycle protein 123
Yarrowia
MIINDKKDQETKVDDTTTLTLTREHLLNCQFSAWYKLYKSITPKTRIIKPLPEDFVNYLSEDGVILPDEEKTSYGSDSGVFEEYSDDEDELDSYVSKLDDFHPKVQAVIDEFGAVAPKLNWSSPQDAIWISPSNSTRCVTVNDVYLLLKSSDYIAHDLTMLDKLGGIPKDFSFELVLRKWININPALEFRCFVKDRELIAVTQRDQNYYEFLIKLKERFLGEIELFFYEHIKDTFPDSSFVFDVYIPEPYDKVWLMDFNVFYPTTDSLIEWSTLVNLDATSPSFDLDLLLIDKELRNASFACQRHSQNKVPMDIVNASMDTEAMVEMLRSQQREMDRLDGDQGGEASATGDTTGDSVANETTAANTTSQDS
Regulates the cell cycle in a nutrient dependent manner.
Q6C101
Q485R8
PY2CR_COLP3
Proline ketimine reductase
Colwellia
MKIISAEQVHQNLNFEELIPLLKQSFSRPFSMPQRQVYSLAPEQSENHDAFALLPSWNEEVIGNKAFTYFPDNAKKHDLPGLFSKIMLFKRQTGEPLALVDGTSVTYWRTAAISALASQLLSRKNSQHLMLFGTGNLASYLVKAHLTVRDIKQVTLWGRNAKKVSKLIADFSILYPAVTFKTSVDVNAEVASADIICCATGAKTPLFDGNSVSAGCHIDCLGNHMTDARECDTTTILRARVFVDSLTNTLNEAGELLIPMAEDAFNKDEIVGELADMCKTPSMLRQSSDEITLFKSVGTAISDLVAAHSVVEKLAD
Catalyzes the reduction of Delta(1)-pyrroline-2-carboxylate (Pyr2C) to L-proline, using preferentially NADPH over NADH as the electron donor. Together with LhpH, is involved in a metabolic pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline. To a much lesser extent, can also reduce Delta(1)-piperideine-2-carboxylate (Pip2C) to L-pipecolate in vitro; however, this activity has likely no physiological significance in vivo since C.psychrerythraea probably possesses no ability to metabolize D-lysine via the L-pipecolate pathway. Does not show ornithine cyclodeaminase (OCD) activity.
Q485R8
B8CXL9
RS20_HALOH
30S ribosomal protein S20
Halothermothrix
MPIIKSAKKRVRITEKRTAYNREWKEKIKQAIKEFEKVVEEGNVEEAEAKLREASKILDKSAGKGIIHKNKAARKKSQLTRQFNKIA
Binds directly to 16S ribosomal RNA.
B8CXL9
Q9V675
CP6G2_DROME
CYPVIG2
Sophophora
MELVLLILVASLIGIAFLALQQHYSYWRRMGVREIRPKWIVGNLMGLLNMRMSPAEFISQLYNHPDAENEPFVGIHVFHKPALLLRDPEMVRNILVKDFAGFSNRYSSSDPKGDPLGSQNIFFLKNPAWKEVRLKLSPFFTGNRLKQMFPLIEEVGASLDAHLRQQPLHNERMRCFDLEAKELCALYTTDVIATVAYGVSANSFTDPKCEFRRHGRSVFEFNLLRAAEFTLVFFLPHLVPFVRFKVVPAEATRFLRKTINYVMSEREKSGQKRNDLIDILIEFRRSTQLAKASGIKDQFVFEGDILVAQAVLFFTAGFESSSSTMAFAMYELAKDTDVQQRLREEIKDALVESGGQVTLKMIESLEFMQMILLEVLRMYPPLPFLDRECTSGRDYSLAPFHKKFVVPKGMPVYIPCYALHMDPQYFPQPRKFLPERFSPENRKLHTPYTYMPFGLGPHGCIGERFGYLQAKVGLVNLLRNHMITTSERTPHRMQLDPKAIITQAKGGIHLRLVRDALGV
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
Q9V675
A7F8R0
NAGS_SCLS1
N-acetylglutamate synthase
Sclerotinia
MPLSLSSRVREELAKETCEKLSTQHQAKKKAKAIDRDFFLSVLGSSATKREARSYIQNFKPPNTAPTKSKIQESTQQNSTENGANLGSIYTATRAVAESPKFVQQPVLPKPAPEGPLLHVALVKIRAPQLLDDETLSGIGKTLSRLSRLGLVSTVVVDGDDGSDTFLRISNCEWRNMVKEQAARVVAAIDASGTEARLVDNVIGIAEDGSNFEQRPYLKGRVHVTLRELLMTPLRRGVLPIIPSIGHTDITQTVVSATANDVVLALTREFAGIWSSESPDEHPNVVKERLQALRSEVSLDRLILVDPLGGIPASDRKNGYHVFLNMEQEYELAKQDLINRGGMHSVAPQKPTLPEASANFTVGDPILLSSFTENKPGELDDSPPPQNGSPAKHDPRMKFHLENLELVRSTLSLLPPSSSALITTPHEAANSEKQPEFKAAGVGTRRQRNPLIHNLLTDKPAFSSSLPVGRLGPMDKNEPISSSTKFAPTTFAKHGMPVTIFPDPKTTPWQPPIAGVPQISLTDPQIDLPRLVHLIEDSFNKKLDVQHYLRRVNNRIAGVIIAGEYEGGALLTWELPPGVPDGSEESRKRMVPYLDKFAVLKKSQGSGGVADVVFKSMVRDCFPGGDNPVNKWYFERSRATLKLSDTNWTMFFTTPEENMDHQTFKDYEAVCKFFGRENVGGYYQQGKRGIYVLDSE
N-acetylglutamate synthase involved in arginine biosynthesis.
A7F8R0
Q988B9
PDLA_RHILO
4-pyridoxolactonase
Mesorhizobium
MSDTKVYLLDGGSLVLDGYHVFWNRGPGGEVRFPVYSILIEHAEGRFLIDTGYDYDHVMKVLPFEKPIQEKHQTIPGALGLLGLEPRDIDVVVNSHFHFDHCGGNKYFPHAKKICHRSEVPQACNPQPFEHLGYSDLSFSAEAAEARGATAQLLEGTTRANSTFEGIDGDVDLARGVKLISTPGHSIGHYSLLVEFPRRKPILFTIDAAYTQKSLETLCQAAFHIDPVAGVNSMRKVKKLAEDHGAELMYSHDMDNFKTYRTGTQFYG
Involved in the degradation of pyridoxine or pyridoxamine (free, phosphate-unbound, forms of vitamin B6). Hydrolyzes 4-pyridoxolactone to 4-pyridoxic acid. Has lower activity toward N-hexanoyl-D,L-homoserine lactone, but is not active toward 5-pyridoxolactone and gamma-butyrolactone.
Q988B9
O93426
SLA_CRODU
Snaclec convulxin subunit alpha
Crotalus
MGRFIFVSFGLLVLFLSLSGTGAGLHCPSDWYYYDQHCYRIFNEEMNWEDAEWFCTKQAKGAHLVSIKSAKEADFVAWMVTQNIEESFSHVSIGLRVQNKEKQCSTKWSDGSSVSYDNLLDLYITKCSLLKKETGFRKWFVASCIGKIPFVCKFPPQC
Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) . The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ).
O93426
P17752
TPH1_HUMAN
Tryptophan 5-monooxygenase 1
Homo
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis.
P17752
Q5FUE6
PXPA_GLUOX
5-oxoprolinase (ATP-hydrolyzing) subunit A
Gluconobacter
MTAKTIDLNADLGESFGHYTMGNDSAMLDIVTSANVACGFHGGDPEVMAETFRIAREKGVSVGSHPGFPDLWGFGRRVMPFTPAQIERIVAYQIGAAQALATYSGHRMTYMKTHGALGNLTERDPAVAEAIVNAVKAVDANLPIMAIALSHLERIGRERGLTVFSEIFADRAYTEDGHLVSRKEPGAVLHDADFAAARAVRMVQNGAIETISGKMLPTRIDTICVHGDNAESVEVARKVRAGFEAAGIAVRALT
Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
Q5FUE6
Q3AF82
REX_CARHZ
Redox-sensing transcriptional repressor Rex
Carboxydothermus
MKGFKIPEATISRLSVYSRYLENLYRKGITTVSSADIAQGVGVTSAQVRKDLAYFGEFGTRGVGYNVKELLDHTLKILGLNNTWNMVVVGAGNLGSALCAYRGFRERGFYIVGVFDNDLTKIGKKINEYEVLPIDKLEEVVRENNVEIGIIAVPAAYAQDVATRLVKAGVKGILNFAPTVLNVPDKVIVRSVDLTVNLEVLTFNIRRD
Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
Q3AF82
B4KCL9
ENOPH_DROMO
2,3-diketo-5-methylthio-1-phosphopentane phosphatase
Drosophila
MALTDLSAKVVLVDIEGTTTSITFVHDVLFPYAKANAGQYLSETWETDDTKQIVEELTQLPQYTEYASTLETRPEINAAHIADFSRYLIEKDLKVTPLKTLQGHIWAKGYASGELKGHVYEDVAVAFQAWSDAGLRIAVYSSGSVAAQKLIFQHSIAGDLLPLLSAHFDTNVGHKQQTESYTRIAESLGVEPQHVLFLTDVPEEASAARDAGMQTVLLARPGNAPLTAEHTSAFPVVANFVALQSLKQP
Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).
B4KCL9
Q1CSB9
RL19_HELPH
50S ribosomal protein L19
Helicobacter
MKNRYIQQFEDAQLKDKTMPAFKAGDTLRLGITIKEGEKTRTQYFEGVCIAIRGNGVDKTFCVRKIGANNIGVEKIFPFYSESLASVEVLRVGRVRRAKLYYLRDRRGKAARIKEVRH
This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
Q1CSB9
Q8LGA1
CCD41_ARATH
G1/S-specific cyclin-D4-1
Arabidopsis
MAEENLELSLLCTESNVDDEGMIVDETPIEISIPQMGFSQSESEEIIMEMVEKEKQHLPSDDYIKRLRSGDLDLNVGRRDALNWIWKACEVHQFGPLCFCLAMNYLDRFLSVHDLPSGKGWILQLLAVACLSLAAKIEETEVPMLIDLQVGDPQFVFEAKSVQRMELLVLNKLKWRLRAITPCSYIRYFLRKMSKCDQEPSNTLISRSLQVIASTTKGIDFLEFRPSEVAAAVALSVSGELQRVHFDNSSFSPLFSLLQKERVKKIGEMIESDGSDLCSQTPNGVLEVSACCFSFKTHDSSSSYTHLS
May activate cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion.
Q8LGA1
Q8D2N4
TYSY_WIGBR
Thymidylate synthase
Wigglesworthia
MKEYLDLLNLILKNGYPKIDRTKTGTLSMFGYQIRINLNEGFPLLTTKYCHFKSIVYELLWFLRGDTNISFLKKNNISIWNKWADKNGNLGPIYGKQWRAWEDKKNNTIDQIEIALNKLKKEPSSRRILVSSWNVGELDLMSIPPCHVLFQLYVINNKLSCQVYQRSCDIFLGLPFNIGSYALLTHIFANQCDLLVEDLIWTGGDIHLYKNHLNQAKLQLTRSPLPLPKIFIKKKPKNLFNYAFNDFLLIDYNHHPKIKAPISI
Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
Q8D2N4
C3MEK8
LSPA_SINFN
Signal peptidase II
Sinorhizobium
MSERNTLFSRPLPIALFILVALVADQAIKYLVEAFLPFQEAVPVVPMLALYRTYNYGVAFSMLSGMEGWFIVGMRLAVVAFVLWLWRRTPKDRFFAHLGYAMIIAGALGNLVDRLLFGYVIDYILFHTATWSFAVFNLADSFITVGAGAIILDELLQTKKTRSLKL
This protein specifically catalyzes the removal of signal peptides from prolipoproteins.
C3MEK8
P86043
PA21B_STRCA
Phosphatidylcholine 2-acylhydrolase 1B
Struthio
AVWQFREMIKCTIPPSDDLLDF
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
P86043
Q9RJ47
MOAA_STRCO
Molybdenum cofactor biosynthesis protein A
Streptomyces albidoflavus group
MLRRSASREGAHVLIDTYGRVATDLRVSLTDRCNLRCTYCMPEEGLQWLAKPDLLTDDEIVRLIDIAVTSLGIEEVRFTGGEPLLRPGLVGIVERVAALEPRPQMSLTTNGIGLRRTATALKAAGLDRVNVSLDTLRPDVFKTLTRRDRHKDVLEGLAAAREAGLTPVKVNSVLMPGLNDDEAPDLLAWAVEHDYELRFIEQMPLDAQHGWKREGMVTAGDILTSLRTRFELTAEGSEERGSAPAERWLVDGGPHRVGVIASVTRPFCSACDRTRLTADGQVRTCLFATEETDLRAALRSDAPDEEIARIWRLAMWGKKAGAGLDDPTFVQPDRPMSAIGG
Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.
Q9RJ47
Q2LVE4
LPXC_SYNAS
UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase
Syntrophus
MYFQRTLKSDLSCQSVGLHSGRKVNMRIRPASSDEGIILVRTDTRYRQMIRVCLENVTDTTLATTIGSSGAAISTVEHILSALSGMGVDNAIIEVDAPEIPIMDGSALPFVNMLKLVGIRTQEKLKKYLVVKKPVSVSEGESFAMLAPSSSFEITYKIEFDHPLIKEQSYHLKLSDETYEKEICSSRTFGFLKDVEYLQAKGLALGGSLKNAVILDEKRIINKEGLRSHNEFVKHKILDAIGDLSLIGMPIVGHFIAYKSGHKLNSMLVKALLEQQENWTTASFLNCQDAHGQNTREKFSIRDIPARKILGAIHA
Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.
Q2LVE4
B9IY25
NAMA_BACCQ
NADPH dehydrogenase
Bacillus cereus group
MNYKLFSPYTIKDVTLKNRIVMSPMCMYSSKNEDGQITNFHLIHYGTRAAGQVGLVMIEATAVLPEGRISNKDLGIWDDSLIEGLHKATTFIHDNGAKAAIQLAHAGRKAELETDALAPSAIPFNETMKMPIEMSKHQIKDTVLAFQQAAVRSKQAGFDVIEIHGAHGYLINEFLSPLTNKRTDEYGGSPENRYRFLREIIESINEVWNGPLFVRISANDYHPDGLTVQDYVQYTKWMKEQGVDLIDCSSGAVVPARIDVYPGYQVQYAKHIKEHANIATGAVGLITTGAQAEQILNNNEADLIFIGRELLRNPYFPRIAANELGFELEEPYQYERAPGKISTNK
Catalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes.
B9IY25
A6UZF6
COQ7_PSEA7
2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase
Pseudomonas
MSADRHYSPIDRFLLQADSALRTLLPFSGQPARPSPAIVEPDGELSEEDTRHIAGLMRINHTGEVCAQALYQGQSLTARLPEVREAMEEAAEEEIDHLAWCEQRIRQLGSRPSVLNPIFYGLSFGVGAAAGLVSDRVSLGFVAATEDQVCKHLDEHLAQIPQEDRKSRAILEQMRVDEEQHSSNALAAGGLRFPAPVKLGMSLLAKVMTKSTYRI
Catalyzes the hydroxylation of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol during ubiquinone biosynthesis.
A6UZF6
Q726Y4
CHED_DESVH
Probable chemoreceptor glutamine deamidase CheD
Desulfovibrio
MRDAVRAKTNRRSVAGMPAELMDLDLRHLHLRIGEGILAARPALIATVLGSCVSVTFHHPSTETGGIFHAMLPTVLGAADGARTPCKYVDAAIETLLGQFARRGIAANDLVVKLFGGAFTMNPEEKQRLRCIVDVGGRNVEVARATLQRFGIEPQSEHILGDRGRKLFFHSGTGEVWVRLLRRTEPPLPSALVCRDDLT
Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.
Q726Y4