accession
stringlengths
6
10
name
stringlengths
6
11
Full Name
stringlengths
1
147
taxon
stringlengths
3
46
sequence
stringlengths
16
2.75k
function
stringlengths
6
5.51k
AlphaFoldDB
stringlengths
6
10
B7N0S9
RSMB_ECO81
rRNA (cytosine-C(5)-)-methyltransferase RsmB
Escherichia
MKKQRNLRSMAAQAIEQVVEQGQSLSNILPPLQQKVSDKDKALLQELCFGVLRTLSQLEWLINKLMARPMTGKQRTVHYLIMVGLYQLLYTRIPPHAALAETVEGAVAIKRPQLKGLINGVLRQFQRQQDELLAEFNASDARYLHPSWLLKRLQKAYPEQWQSIVEANNQRPPMWLRVNRTHHSRDSWLALLDEAGMKGFPHADYPDAVQLETPAPVHALPGFEEGWVTVQDASAQGCMTWLAPQNGEHILDLCAAPGGKTTHILEVAPEAQVLAVDIDEQRLSRVYDNLKRLGMKATVKQGDGRYPSQWCGEQQFDRILLDAPCSATGVIRRHPDIKWLRRDRDIPELAQLQSEILDAIWSHLKSGGTLVYATCSVLPEENSLQIKAFLQRTADAELCETGTPEQPGKQNLPGAEEGDGFFYAKLIKK
Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
B7N0S9
Q0T3C3
COBS_SHIF8
Cobalamin-5'-phosphate synthase
Shigella
MSKLFWAMLSFITRLPVPRRWSQGLDFEHYSRGIITFPLIGLLLGAISGLVFMVLQAWCGAPLAALFSVLVLALMTGEFHLDGLADTCDGVFSARSRDRMLEIMRDSRLGTHGGLALIFVVLAKILVLSELALRGEPILASLAAACAVSRGTAALLMYRHRYAREEGLGNVFIGKIDGRQTCVTLGLAAIFAAVLLLGMHGVAAMVVTMVAIFILGQLLKRTLDGQTGDTLGAAIELGELVFLLALL
Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.
Q0T3C3
Q9D8E6
RL4_MOUSE
60S ribosomal protein L4
Mus
MACARPLISVYSEKGESSGKNVTLPAVFKAPIRPDIVNFVHTNLRKNNRQPYAVSELAGHQTSAESWGTGRAVARIPRVRGGGTHRSGQGAFGNMCRGGRMFAPTKTWRRWHRRVNTTQKRYAICSALAASALPALVMSKGHRIEEVPELPLVVEDKVEGYKKTKEAVQLLKKLKAWNDIKKVYASQRMRAGKGKMRNRRRIQRRGPCIIYNEDNGIIKAFRNIPGITLLNVSKLNILKLAPGGHVGRFCIWTESAFRKLDELYGTWRKAASLKSNYNLPMHKMMNTDLSRILKSPEIQRALRAPRKKIHRRVLKKNPLKNLRIMLKLNPYAKTMRRNTILRQARNHKLRVKKLEAAATALATKSEKVVPEKGTADKKPAVGKKGKKVDAKKQKPAGKKVVAKKPAEKKPTTEEKKPAA
Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.
Q9D8E6
A5CY18
SECA_VESOH
Protein translocase subunit SecA
Candidatus Vesicomyosocius
MSIINNILSKIVGSRNDRLIKVLYKTVNQITELESNMQALSDEQLKSKTQEFKDRLNKKETLNSILIEAFAVIREASIRVLDLRHHDVQLIGGIVLNNGNIAEMGTGEGKTLVATLPAYLNALNGKGVHIVTVNDYLAFRDAQWMGKVFNFLSMSVGIITSNMSYENKQVAYLCDIVYATNNELGFDYLRDNMAFTSEQKVQRMLNFAIVDEVDSILIDEARTPLIISGPTDDYAQIYQAINHMIPHFTKQIESGAGKEIVIEVAGDYTVDEKHKQVFLTDNGHGKAERLLIDAGALLEGVSLYDASNILLMQHINSALRAHILFQKNVDYIIQNDEVVIVDEFTGRTMLGRRWSEGLHQAIEAKERVSIKKENQTLASITFQNYFRLYRTLSGMTGTADTEAVEFQDIYGLETVVVPPNKPSTRVDKSDLIYLTTQEKFKAIALEVANCQKTGQPVLVGTSSIENSELISTLLEKNNIKHEVLNAKQHEREAIIIANAGSIGAVTIATNMAGRGTDIVLGGKLLEQATNKQKIDWQNRHDDVIKAGGLHIVGTERNESRRVDNQLRGRSARQGDVGSTRFYLSLEDNLMRIFASEKMSSTMQKLGMKKGESIEHKMVNRAIENAQRKVEGMNYDARKHLLEYDDVANDQRKVIYQLRDDLMSVNDVQDRFISIREKVIKQLFSDYISAELMEEDWNVEGFYNALKSDYSVDLPLQQWLNKGVDIDELQSRIIQGMSTICDYKEETVGTKPMREFEKAVMLKTIDHYWKEHLATMDYLRQSVNLRGYAQKNPMQEYKRESFAMFTSLLDTINIEIVKSLSNVTINENTDILDVEQQNNDDAQATHSNPNEQTKQASITNNIQTQTDQQNTYQRKEKKVGRNEPCPCGSGKKYKKCHG
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
A5CY18
Q089Q6
EFTU2_SHEFN
Elongation factor Tu 2
Shewanella
MAKAKFERIKPHVNVGTIGHVDHGKTTLTAAISAVLSKTYGGEVKNFAQIDNAPEERERGITINTSHIEYDTPIRHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLSRQVGVPFIIVFMNKCDMVDDEELLELVEMEVRELLSEYDFPGDDLPVIQGSALKALEGQPEWEAKILELAEALDTYIPEPARDIDKPFLLPIEDVFSISGRGTVVTGRVERGIVRVSDEVEIVGVRPTTKTTCTGVEMFRKLLDEGRAGENCGVLLRGTKRDDVERGQVLAKPGSINPHTTFESEVYVLSKEEGGRHTPFFKGYRPQFFFRTTDVTGTIELPEGVEMVMPGDNIKMVVTLIYPIAMDDGLRFAIREGGRTVGAGVVAKIIA
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
Q089Q6
P96723
YWQK_BACSU
Immunity protein YwqK
Bacillus
MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGLAYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRKKSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE
Immunity component of one of 6 LXG toxin-immunity modules in this strain. They promote kin selection, mediate competition in biofilms, and drive spatial segregation of different strains, indicating that LXG toxins may help avoid warfare between strains in biofilms. Mediates intercellular competition during biofilm formation; disruption of the operon disadvantages the bacteria, but overexpression of the cognate immunity protein restores growth in competition with wild-type. In situ neutralizes the toxic effect of cognate toxin YqcG . Probably neutralizes the ability to inhibit growth of cognate toxin YwqJ. Probably does not have immunity protein activity on other LXG toxins (Probable).
P96723
Q9XI91
IF5A1_ARATH
Eukaryotic translation initiation factor 5A-1
Arabidopsis
MSDEEHHFESSDAGASKTYPQQAGTIRKNGYIVIKNRPCKVVEVSTSKTGKHGHAKCHFVAIDIFTSKKLEDIVPSSHNCDVPHVNRTDYQLIDISEDGYVSLLTDNGSTKDDLKLPNDDTLLQQIKSGFDDGKDLVVSVMSAMGEEQINALKDIGPK
The precise role of eIF-5A in protein biosynthesis is not known but it may function as a bimodular protein capable of binding to both RNA and proteins. Involved in xylogenesis.
Q9XI91
Q1GIC1
ISPG_RUEST
1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase
unclassified Ruegeria
MSMNHIRPWRNIERRKSRQIHVGNVPVGGDAPIAVQTMTNTLTTDIKGTIAQVQAAADAGADIVRVSVPDEASARALKEIVRESPVPIVADIHFHYKRGIEAAEAGAACLRINPGNIGDEKRVAEVIKAARDHNCSIRIGVNAGSLEKHLLEKYGEPCPDAMVESGLDHIKILQDHDFHEFKISVKASDVFMSAAAYQMLADATDAPIHLGITEAGGLMSGTIKSAIGLGQLLWMGIGDTLRVSLSADPVEEVKVGFEILKSLGLRHRGVNIISCPSCARQGFDVIKTVETLEERLEHIKTPMSLSIIGCVVNGPGEALMTDVGFTGGGAGSGMVYLAGKASHKMSNDQMIDHIVEEVEKKAAALDAQAAEDMKAAE
Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.
Q1GIC1
Q68W81
RL2_RICTY
50S ribosomal protein L2
typhus group
MALKNFNPITPSLRELVQVDKTNLWKGRPLKSLTKGMSKTGGRNQQGRITSWHRGGGHKKLYRVIDFKRKKIDIFAVVERIEYDPNRTAFIALIKYDDGEYSYILAPQKLSIGDRVISSQAADIKIGNCLPLKSIPIGTTLHNVEMKVGKGGQIARSAGTSVELVGKDSGYAQIKLRSGEFRLVPLDCKATIGSISNPDQKNINLGKAGRNRWLGWRPHVRGVAMNPIDHPHGGGEGKTSGGRHPVTPWGFSTKGKKTRKNKRTSKFIVKKRK
One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.
Q68W81
Q74IP1
ACP_LACJO
Acyl carrier protein
Lactobacillus
MTEEEIFNKIADMISERFSIDRDKITKDLNFQNDLDADSIDFVELVMDLEDTFGAEIPDDDAEKLQTVGEAVEYIKSHQN
Carrier of the growing fatty acid chain in fatty acid biosynthesis.
Q74IP1
B4R8N0
RS14_PHEZH
30S ribosomal protein S14
Phenylobacterium
MAKKSAVNRNERVKKLVKQYAAKREALKAIANDESLPLEERFEARLKLAELPRNSAAVRIRNRCEVTGRPRAYYRKLKMSRVSLRELGSHGLIPGLVKSSW
Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.
B4R8N0
Q9DC37
MFSD1_MOUSE
Major facilitator superfamily domain-containing protein 1
Mus
MEDEDGEDRALLGGRREADSAVHGAPRALSALCDPSRLAHRLVVLSLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRIFGIRWGTVIFSCFVCIGQVIFALGGIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGKIEALLGSAGHMTLGVTLMIGCITCIFSLICALALAYLDRRAEKILHKEQGKTGEVIKLRDIKDFSLPLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSHMMLAFTFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIACVSLSLLAVVCLYLVNRAQGGNLNYSAKQRERMKLSHPE
Lysosomal transporter which is essential for liver homeostasis . Required to maintain stability and lysosomal localization of GLMP .
Q9DC37
E4UYA3
MEP1_ARTGP
Fungalysin MEP1
Nannizzia
MHGLLLAAGLLSLPLRVLAHPQPSTSLTSQGVDLNAYRMADRSSYMSSDEMKLEQPSISSLSGGNYVETATEVVKRMMPGVTFRMVDDHYVGESGISHVYFRQTMHGMDIDNSDFNVNIGKDGKVLSFGNSFYTNPTPDKAPVEKRDFSDPMKALHGARKALNLPINADKATIKSMNEHEVMFMGTSGALSDPQGKLCYMAKEDGTLALTWRVETDMGDNWLLSYVDAKDTDKVHNVVDYVSHATYQVYPWPVPDPTEGKRAVLQNPWNLKASPFTWISDGKNNYSTTRGNNAIAQANFDGGSDYLNNYRPNNKNLKFEYPYAPNMSPPKSYIDASVTQLFYSANMVHDLYYMLGFTEKAGNFQVNNRNQGGKGGDFVILNAQDGSGTNNANFATPPDGQPGRMRVYIWTKAKPARDSSFEAGTVIHEYTHGLSNRLCGGPANSACLNGMESGGMGEGWGDFFATAIRLKPNDNRNANYVHGEWVNNSPRGNRMFPYSTSLQTNPLVYTSCNKYNEVHAIGTVWCSILYEVLWNLIDKHGKNDGPTPVFENGVPKDGKYLAMKLVLDGMAIQPCKPTFVQARNAILDADMNLTKGANKCELWKAFAKRGLGTGAKYDPKNRTGSKAVPKECQ
Secreted metalloproteinase that allows assimilation of proteinaceous substrates and probably acts as a virulence factor.
E4UYA3
P0CV25
RLR78_PLAVT
Secreted RxLR effector protein 78
Plasmopara
MMKTVMMMLAILATAKAEPQLAAASSRVILLLDFKKAYDSVAREFLFLVLLRFEFSPMFVRMLRKLHDGTTARFLVNGELSEPQEVVSGIRQGCSLAPLLFILAAEVLALSIQ
Secreted effector that dos not suppress the host cell death induced by cell death-inducing proteins.
P0CV25
P63903
DCD_NEIMA
Deoxycytidine triphosphate deaminase
Neisseria
MSIKSDKWIRRMSEEFGMIDPFEPNQIKEADGKRIISYGTSSYGYDIRCANEFKIFTNINSTIVDPKNFDPKNFVTVEDDCCIIPPNSFALARTVEYFRIPRNVLTVCLGKSTYARCGIIVNVTPFEPEWEGYVTLEFSNTTPLPAKIYAGEGVAQVLFFESDEICETSYKDRNGKYMGQTGVTLPKA
Catalyzes the deamination of dCTP to dUTP.
P63903
A4XLF1
TRMD_CALS8
tRNA [GM37] methyltransferase
Caldicellulosiruptor
MVFKVLTLFPEVILQATNFSILKRAQEKGLIKIEAINIRDYTKDKHKRTDDYPYGGGFGMVMTAQPIVDAYESIKSSKPHRVIYLTPQGKKYTQDIAKEFSKEEELVIICGHYEGIDQRVIDLIVTDEISIGDYVLSGGEYAALVLIDSISRLVEGVIEKKSVEEESFSECLLEYPHYTRPYEFRGLKVPEVLLSGNHEKIKKWRRYQSLLKTIKSRPDLINAANLTKEDIEFLIKYCESQKIVL
Specifically methylates guanosine-37 in various tRNAs.
A4XLF1
O82598
TIP13_ARATH
Tonoplast intrinsic protein 1-3
Arabidopsis
MPINRIAIGTPGEASRPDAIRAAFAEFFSMVIFVFAGQGSGMAYGKLTGDGPATPAGLVAASLSHAFALFVAVSVGANVSGGHVNPAVTFGAFIGGNITLLRAILYWIAQLLGAVVACLLLKVSTGGMETAAFSLSYGVTPWNAVVFEIVMTFGLVYTVYATAVDPKKGDIGIIAPLAIGLIVGANILVGGAFDGASMNPAVSFGPAVVSWIWTNHWVYWVGPFIGAAIAAIVYDTIFIGSNGHEPLPSNDF
Potential aquaporin, which may facilitate the transport of water and small neutral solutes across cell membranes.
O82598
Q6G0J2
LLDD_BARQU
L-lactate dehydrogenase
Bartonella
MIISSTFDYRKAAKRRLPPFLFHYIDGGAYAEETMRRNYADLQALALRQRILRQVGEVDLSIKLFDQRLNLPIVLAPVGLTGMYARRGEVKAARAAVAKGIPFTLSSVSVCSLAEVHAEVGSGFWFQLYVLKDRGFMRDVLERSWLAGVRTLVFTVDMPVPGARYRDAHSGMSGPYAGLRRILQAVVHPHWAWNVGIMGRPHDLGNVSTYLQKKITLEDYVGWLGANFDPSIGWSDLQWIRDFWKGKMILKGILDPQDAREAVQFGADGIVVSNHGGRQLDGVLSTARALPAIAEVVTGDLTILADSGVRSGLDVVRMIAQGADAVMIGRAFIYALAAAGEKGVMHLLDLFANEMRVAMTLTGVRAVKEITHESLASTDALNQ
Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain.
Q6G0J2
Q7SZK7
OFD1_DANRE
Oral-facial-digital syndrome 1 protein homolog
Danio
MSASKEESLSPDEMRQKLYQTFKSRGLLDTLKTQLRNQLIQELQAPVRRGESASRRSADHTDSVLVSACNSVVVDHLRSAGYEYTLSVFQPECGLSKDKVLSSRDVLQIMKISPHMPLYKSLVSNIQSGQSGFLKSLLMELTDHSVYRDCSDNSTQTTSIAAHKESLVEKMQLIDEEYEVLRHRGDRWASVEAKLAEYRKEIQEQAQIELNAKLQHFMDVEIAKVKQEEKERSRKEILELRRDMEKTYELKSEALISREKNAIERLQKHQEIEEKDIYAQRQAVLREIESVRSREMELRQRMEAFDKSCALHEEKVKTMEDLLRRRELSVKTMEDSFEQKLKSELLKYQLELKEENMKRPEKLTENEERIRAEAARLQKEAAVVDAKTEDYERKSSEVKQLLMELESSRSQASLLKQQKELLREQLENMRDYPELKKHTLELQTRISLLKQQLEEKQQHNQRLTQELSAPSHEHLMLQAELRRLEAEHKLEKEELETQKNVLHTQLQHEVQQCALLKTQLMECEERTKWMNTHTEELKLQLQQTQQGPALRGPKSRTVAPEHDSDMVISALSRIRELEQEAERLEEAYRSHQQRALSAEDPTLHRGSQNYSRATAAQQHRVISRSPIFAGRPIEEEHEEFSRTPSPAERLASPPARRLSSTPQSASRSKRRADEEHDEHSLNPECVKGSSNTDRPALMFPERLISPIPAEELSSSISPNSPVMKSTTRHTQSPAKLQEILLSSSSQESSPQPEKITLHDLTEPIQMVSADQPCLLKDCEPELQQDHPDVQISSSSSSSSSSQREEEQQRETHTLQQQPHEEQTQEQRDDAGGHVTSAASPTGGAEEANPLQRYMQMLMQDKQQEQSPNKESSGSHEENLQSESHEHSAGVISHDEADDDFW
Component of the centrioles controlling mother and daughter centrioles length. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis.
Q7SZK7
A6WUU4
KDSB_BRUA4
CMP-2-keto-3-deoxyoctulosonic acid synthase
Brucella
MLQTLKTLTLIPARMASTRLPNKPLADICGKPMIVHVADRAAAAKLGRTVVATDSEEIFAIVTAHGHEAIMTREDHESGSDRIYEALMKVDPAGEFDAVVNVQGDLPTIDPDIIRRALLPLEDGPADIATLGVEIEEESEKTNPSVVKIVGSPLAGNSRLRALYFTRATAPYGEGPLYHHIGLYAYRRSALERFVKLGPSPLEKREKLEQLRALEAGMRIDVELVRTVPLGVDTQADLDRARILVAQGI
Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.
A6WUU4
A1JLC3
MNTH_YERE8
Divalent metal cation transporter MntH
Yersinia
MLNSRVVDTPPRTSRRIKLSLMGPAFIAAIGYIDPGNFATNIQAGASFGYTLLWVVVWANFMAMLIQLLSAKLGIATGKNLAEHIRDRFPRPAVWAYWVQAEIIAMATDLAEFIGAAIGFKLLLGVTLLEGAVLTGIATFLILMLQKRGQKPLELVIGGLLLFVAAAYIVELVFSRPEIAALGRGMLIPDLPNRDAVFLAAGVLGATIMPHVIYLHSSLTQTAGENSKADRYASTKLDVAIAMTIAGFVNLAMMATAAAAFHFNGYGSIAEIEQAYLTLQPLLGNAAATIFGLSLVAAGLSSTVVGTLAGQVVMQGFVRFYIPIWVRRTVTMLPSFIVILMGMDATRILVMSQVLLSFGIALALVPLLAFTGNKELMGDMVNSKLIQILGKLIVLVVIGLNAYLLVSLI
H(+)-stimulated, divalent metal cation uptake system.
A1JLC3
B0BUQ3
RL16_RICRO
50S ribosomal protein L16
spotted fever group
MLAPKKQKFRKAHKGRVASTAKAGTTLAFGSFGLKSIDGWRVTARQIEAGRKAATRCMKRQGRLWIRIFPDVPVSQKPAEVRMGKGKGSPEFFAVRVSPGRIMFEIEGVEENVALRALELASAKLPVRTRIVRRYE
Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.
B0BUQ3
Q6MDC8
UVRC_PARUW
Excinuclease ABC subunit C
Candidatus Protochlamydia
MSYDPKKIDLFPTLPGVYLMKNEEGEVLYVGKAKNLRQRVKQYFVPGRDGRLMIPYLVAKINYIETIVVTSEKEALLLENNLIKQHKPRYNALLKDDKSYIALKISQNDAWATVRLVRYKGTPEPDGLYFGPYTSAQAARQTLDLLNRLFPLRQCSDQEFARRTRPCLLYQMKRCVGPCTQKCTKGEYQQHLDRTIKFLRGQNKDVLKDLYEEMRLLSEQLEFEKANHLLRTIRYIEKTIESQYVDRPLGHDADAIGLFRYGEHVVVVLMIFRGGKLVGSRHFEFDNIIEEDHELLTSFLLQHYEGATEIPSEILLPSKISDEHPVEEILSARREQKVNLQIPQRGEKKALIEIAQKNAEALFKTQKDEATLREKTLLEMQELLFLTNYPTRIECFDNSNIAGSEPVSSMVAFTDGLKDSKRYRTYRLKIGSKPDDYAAMYEVLTRRYKRAKEENDMPDLVVVDGGKGQLNIAIKVFEELNITGVDLLGLAKEAGRHDKGMTAEQVFTCYQKEPILLKANSPILFLLQKIRDEAHRVAISFHRKRRSKKTLKSALDDIPGIGPAKRKTLLTHFGSLKKIELAADAELREVKGISAANIEAIRTFFQGRKE
The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
Q6MDC8
P28880
O16A_CONST
SNX-157
Pionoconus
MKLTCVMIVAVLLLTACQLITAEDSRGTQKHRTLRSTARRSKSESTTRCRSSGSPCGVTSICCGRCYRGKCT
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). In vivo, this toxin is a potent paralytic toxic in lower vertebrate species, but it is much less effective in mammals.
P28880
Q74CB0
DXS2_GEOSL
1-deoxyxylulose-5-phosphate synthase 2
Geobacter
MSRILDRVDSPSDLKGLTTAELGILAEEIRQEIITVCSRNGGHLAPSLGVVELTLALHRVFTSPEDKIVWDVGHQAYAHKLVTGRRDRFATLRTLGGISGFLKRAESPHDVFDAGHASTSISAALGLAAARDLAGRNNKVVAVIGDGSMTGGIAYEGLNHAGHLNRDLVVVLNDNEMSIAENVGALSNFLSRTVTSEFVHTLKKDVETFLGGLDRIGRNVLKVAKRAEESLKGLFTPGMLFEAFGFEYIGPIDGHDIGRLTETFEKVKRFDDAVLIHVLTKKGKGFAPAEAKPSLFHGVGPFDPVSGEIVKGKGGATSYTGVFGQALTRIADEDERVVAITAAMPDGTGLGSFSARHPGRFFDVGIAEQHGVTFAAGLAAEGYRPVFAIYSSFLQRAYDQLFHDVCLMNLPVTFAIDRSGVVGSDGPTHHGLFDLSYLRTLPNMVVMAPKDENELQHMLKTAIDHNGPAAVRYPRGNGLGVPLDQSLAPIPLGTSEVLRAGSGTCVVLAVGAMVGPALEAANTLEGEGIDLTVVNVRFVKPLDRELILSYVGRAGTLVTIEENVLQGGFGSAVLELLADEGVGGVAVHRFGYPDRYVEQGEQHELRSRYGLDAEGIAGRIRTLSAR
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Q74CB0
Q88AH6
FPG_PSESM
DNA-(apurinic or apyrimidinic site) lyase MutM
Pseudomonas
MPELPEVETTRRGIAPHLEGQRVSRVIVRDGRLRWPVPEDLDIRLSGQRIVQVSRRAKYLLIQAEVGTLISHLGMSGNLRLVEAGLAALKHEHVDIELESGLALRYTDPRRFGAMLWSHDPHNHELLIRLGPEPLTDLFDGERLYERSRGKSIAVKPFIMDNAVVVGVGNIYATEALFAAGIDPRREARGISRARYLKLAIEIKRILAYAIERGGTTLRDFIGGDGKPGYFQQELFAYGRGGQPCKVCGTTLREIKLGQRASVYCPKCQR
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
Q88AH6
P94679
TSAM1_COMTE
Toluenesulfonate methyl-monooxygenase oxygenase component TsaM1
Comamonas
MFIRNCWYVAAWDTEIPAEGLFHRTLLNEPVLLYRDTQGRVVALENRCCHRSAPLHIGRQEGDCVRCLYHGLKFNPSGACVEIPGQEQIPPKTCIKSYPVVERNRLVWIWMGDPARANPDDIVDYFWHDSPEWRMKPGYIHYQANYKLIVDNLLDFTHLAWVHPTTLGTDSAASLKPVIERDTTGTGKLTITRWYLNDDMSNLHKGVAKFEGKADRWQIYQWSPPALLRMDTGSAPTGTGAPEGRRVPEAVQFRHTSIQTPETETTSHYWFCQARNFDLDDEALTEKIYQGVVVAFEEDRTMIEAHEKILSQVPDRPMVPIAADAGLNQGRWLLDRLLKAENGGTAP
Involved in the toluene-4-sulfonate degradation pathway. Does not discriminate between the sulfonate and the carboxyl substituents and can also be involved in the p-toluenecarboxylate degradation pathway. Can use toluene-4-sulfonate, p-toluate, m-toluate and 4-ethylbenzoate as substrates, but not p-xylene, toluene and p-cresol. Catalyzes also the demethylation of 4-methoxybenzoate to 4-hydroxybenzoate.
P94679
A8GIF8
XNI_SERP5
Flap endonuclease Xni
Serratia
MMIHLLIVDALNLIRRIHAVQGSPCVNACQHALQQLIQHSRPTHAVAVFDEDDRSESWRHQILPDYKAGRSPMPDNLQQEMPQLRQAFESLGVACWHSPGNEADDLAATLTAKVAGGGHQVTIVSTDKGYCQLLAPSVQIRDYFQKRWLDMPFVQQEFGVSPQQLSDYWGLAGISSSKIPGVAGIGPKTAVLLLQQAGSLDGLYQDLEQVPEKWRGKLEQHREMAYVSKRVATLRTDLALTGNLQQLRLPV
Has flap endonuclease activity. During DNA replication, flap endonucleases cleave the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
A8GIF8
P52020
ERG1_RAT
Squalene epoxidase
Rattus
MWTFLGIATFTYFYKKCGDVTLANKELLLCVLVFLSLGLVLSYRCRHRNGGLLGRHQSGSQFAAFSDILSALPLIGFFWAKSPPESEKKEQLESKRRRKEVNLSETTLTGAATSVSTSSVTDPEVIIIGSGVLGSALATVLSRDGRTVTVIERDLKEPDRILGECLQPGGYRVLRELGLGDTVESLNAHHIHGYVIHDCESRSEVQIPYPVSENNQVQSGVAFHHGKFIMSLRKAAMAEPNVKFIEGVVLRLLEEDDAVIGVQYKDKETGDTKELHAPLTVVADGLFSKFRKNLISNKVSVSSHFVGFIMKDAPQFKANFAELVLVDPSPVLIYQISPSETRVLVDIRGELPRNLREYMTEQIYPQIPDHLKESFLEACQNARLRTMPASFLPPSSVNKRGVLLLGDAYNLRHPLTGGGMTVALKDIKIWRQLLKDIPDLYDDAAIFQAKKSFFWSRKRSHSFVVNVLAQALYELFSATDDSLRQLRKACFLYFKLGGECLTGPVGLLSILSPDPLLLIRHFFSVAVYATYFCFKSEPWATKPRALFSSGAILYKACSIIFPLIYSEMKYLVH
Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
P52020
Q72TF8
LGT_LEPIC
Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase
Leptospira
MIDRIPVPFLNPLFKFLFNREWDGPSTFSILMMIGFLTASYLLPKELKRRKLEPEHSDWLLLLGILGTLVGAKIFFVFEIWDQIFVETPGFDGKYIYPLTHWYGFPGRMSLWDNLFSGSGLVFYGGFLFGILFITLYMKYFQLDIASYLDAAVPSMAIGYAIGRLGCWVSGDGCYGFATNVEIPLLVFNYHGAHPSGVPVWNTPLIESIISFLFFFYFQFWARNQNFKKFSIGAQYLVLHGFARLLVEFLRVNKAVFPLMDPPAFVNIPNAEQNPEFLTQYYWHGFSQSQLVSIIIILVGAFFILKWKLWKKENTSNI
Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.
Q72TF8
Q21IQ9
CHEB1_SACD2
Protein-glutamate methylesterase/protein-glutamine glutaminase 1
Saccharophagus
MAYKVLVVDDSQFFQVRLKQIINEHPDLEVVGIAANGQEAIDLEESLRPDIISMDYEMPHLDGISAVRSILSKRPIPIVMFSSMTYEGATITLEALDAGAVDFIPKNFAEVSRDSVVLKKRLHEKLLLFAQKAKPSVAARSTTQPSGVRPSALGANLSSSRSPRPASSAPSAPKKRIKGLVKLVAIGASTGGPVAVSEIITRLPANFPVPVIVAQHMPENFTKAFSERLNRQSAVEVREAQDGDLLKSGVVYVAPGGNQLMVDKTGRSIRILDGDARLTYKPSVDVLFASAASAMGDKVLAIVLTGMGADGCDGAKLLKQKGATIWGQDKDSCVVYGMPAAVAKAGLTDEVLPLDQVWQRLVSDV
Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.
Q21IQ9
A7IMW3
IDI2_XANP2
Type 2 isopentenyl diphosphate isomerase
Xanthobacter
MDESGAGRRKEDHIDIVLAGGRVASRLDAGFDRVRFVHCALPELDLDAIDLSTRFLGRPLKAPFLISAMTGGPARAESINAHLAEAAQALGIALGVGSQRIAIEDGSAGGLGADLRRRAPDIALFANLGAAQLLAARGLDAARRAVEMIGADVLVIHLNPLQEAIQQGGDRDWRGVFDRIGSLCVSLSAPVVVKEVGFGLSGAVARRLADCGVAALDVAGAGGTNWALVEGERGTGRSRAVATAFADWGIPTAQAVVEVRAACPDLPLIASGGVRHGVDAAKAIRLGADLVGQAAGTLKAAITSTEAVVEHFSQMTDQLRIACFATGAADLDALRRVPLATMD
Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
A7IMW3
Q8ZLE2
ACPT_SALTY
4'-phosphopantetheinyl transferase AcpT
Salmonella
MYQVVLGKVSTLSAGQLPDALIAQAPQGVRRASWLAGRVLLSRALSPLPEMVYGEQGKPAFSAGAPLWFNLSHSGDTIALLLSDEGEVGCDIEVIRPRDNWRSLANAVFSLGEHAEMEAERPEQQLAAFWRIWTRKEAIVKQRGGSAWQIVSVDSTLPSALSVSQCQLDTLSLAVCTPTPFTLTPQTITKAL
May be involved in an alternative pathway for phosphopantetheinyl transfer and holo-ACP synthesis. The native apo-protein substrate is unknown.
Q8ZLE2
Q0I6N5
MNME_SYNS3
tRNA modification GTPase MnmE
unclassified Synechococcus
MSGIGPDQALSIAAIATAVAPGQGGIAVIRLSGPSAVRAVAAITVIPGQQVWESHRVLYGHVVAAGGVERLDEVLVLVMLAPRSFTGEDVVEIHCHGGVIAVQQVLARVLEQPGVRRALPGEFSQRAVLNGRLDLTRAEAIGDLVGARSQRAAQLAMAGLDGGIQKKMVVLRERLLDQLSELEARVDFEEDLPPLNGEALLQELQAVRLELLTLVADGERGSVVRHGLRVALVGRPNVGKSSLLNLLSRRERAIVTDLPGTTRDLLESEIVLDGVPITLLDTAGIRATSNAVEKLGIARSRDALASADLVLLLFDLAQGWSDDDQALFALIPEGVPCLRVGNKADLPLKAEPVAETVAASVADVRLSAVTGDGEQALVQAVLERCGALGEQPLLLALNQRQSDLAVTAAEALARSEQVAADGLPWDFWTIDLRQAIRSLGEITGEQLTESVLDRIFSRFCIGK
Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.
Q0I6N5
Q5HQL0
MNHA1_STAEQ
Mnh complex subunit A1
Staphylococcus
MSLLHIAVLLPLIFALIIPFLYRFVKRIHLGWFVLPVPIVLFIYFISLISMTMSGNNVMKNLNWMPHIGMNFNLYVDGLGLLFSLLITGIGSLVVLYSIGYLSKSEQLGNFYCYLLLFMGAMLGVVLSDNFIILYLFWELTSFSSFLLISFWREKKASIYGAQKSLIITVLGGLSMLGGIILLSLATDTFSIQAMISKASDIQNSPFFILVMILFMIGAFTKSAQVPFYIWLPDAMEAPTPVSAYLHSATMVKAGLYLIARITPIFAISEGWVWTITLVGLITLFWASLNATKQHDLKGILAFSTVSQLGMIMSMLGIGAVSYHYQGANSQLYVAGFVAAIFHLINHATFKGALFMITGGIDHSTGTRDVKKLGGLLTIMPISFTLTVITTLSMAGVPPFNGFLSKEKFLESMINVTHLNLMSLNTLGILLPIIAIIGSIFTFVYSIKFILHIFFGSYKPEALPKQAHESSILMLISPIILTSLVIVFGLFPSILTQSIIEPASVAVSQTSNITAEFHLFHGITPAFLSTIGIYIIGILLLISFSYWVRLLQAHPYQLTLNHWYDTSGQRIPGYSENITNSYVTGFSRNNLVIILGILIALTFVTVISVPFSIDFKNVSHLRVFEGATVLFLLIASTFIIFAKSRLFSIIMLSAVGYAISVLFIFFKAPDLALTQFVVESISTALFLLCFYHLPNLNRYNEKPTFKLTNAVISIGVGLSVIILGLIGYGNRHFDSITKFYQEHVFDLAHGKNMVNVILVDFRGMDTLFESSVLGIAGLGVYTMIKLRLKQKNQSSEVNDHE
Mnh complex is a Na(+)/H(+) antiporter involved in Na(+) excretion.
Q5HQL0
A1WRC4
SYM_VEREI
Methionyl-tRNA synthetase
Verminephrobacter
MPSTRKLFVTTALPYANGPFHLGHLMEYIQADIWVRFQRMQGHEVNFVGADDTHGAPIMIAAEKAGKTPQQFVADIAAGRKPYLDGFHLSFDNWHSTDAPENHELARQIYRDLRDRADGSLIERRSIEQFFDPGKSMFLPDRYIVGECPRCHAKEQYGDNCEQCGSVYAPAELIDPVSALSGAKPELRSSEHFFFKLSDPRCVEFLQRWTQDGKLQPEVANKVREWFGLRSNPDGSCSEGLDDWDISRDAPYFGIEIPDAPGKYFYVWLDAPVGYLAALKNLLEKRGQNYDAYMADPALEQYHFIGKDIVTFHTLFWPAMLHLSGRKTPDNVFVHGFLTINGEKMSKSRGTGLDPLKYLSLGMNAEWLRYYLATKLSARNEDMDLGTEDFMVRVNSDLIGKYVNIASRAAGFLTKRFAGRLTSDFGAAGLALLADLHGARDTIAQWYQAREFGKATREIMLLADKVNAYVDRNKPWELAKDAANGQALHQVCSVLINAFATLTRYLSPVLPALARAAQDFVGQDMQRWDAGGAVQAIAPYQHLMQRVTPEQLAALFQPPAAAQIAAAGAQEPGGLALAPGIGIDDFDRVDLRVALIVDCAAVAGSTKLLRLTLDIGEGRQRQVFSGIASACQPADLIGKHTVMVANLAPRRLKFGVSEGMVLAASHGDEKANPGIYLLAPGPGAKPGMRVR
Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
A1WRC4
Q3JVC1
PLSY_BURP1
Lysophosphatidic acid synthase
pseudomallei group
MQILLATVAAYLIGSVSFAVVVSAAMGLADPRSYGSKNPGATNVLRSGNKKAAILTLVGDAFKGWLAVWLVKRFGIGGEIGVALAAIAVFLGHLYPVFFRFQGGKGVATAAGVLLAVHPVLGLATALTWLIVAFFFRYSSLAALVAAVFAPIFDVFLFGTHDNPVAWAVLAMSVLLIWRHRSNISKLLAGEESRIGQKKKTGA
Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
Q3JVC1
Q4WQ14
PRM1_ASPFU
Plasma membrane fusion protein prm1
Aspergillus subgen. Fumigati
MLFSRSGRSIFPLLPPYAAHAPNPNQGHIIALPPDGLTPYLGLRARLSQVWINRWTILLLLVLVRVLLAASGLQADMSTAKREALSACTSVESMGSSMASMPHYLSQGVNELTATGVEKAVSGLKSMLMLTITGVEELVLFIIKVLYQTYLCLFTLAVRGSVHVAVGVIKEAADFLNSTVKEVGDDIGKAVSTFESAFNKFLDGVNTVASAFGASVPTLDLNSSISTLENLQLPSSIDQGLDKLNSSLPTFDEVNNFTQTVLRTPFEEVKKLVNESLGTYTFDRSLLPVPAKEQLTFCEGSNGIDSFFDSVTDLVMKARKIFIAILIVAATLACVPMAWQEIRRWRSMKERSQLVRKEAHDPMDVVYIVSRPYTAAAGIKAASRFSNSRRQILVRWAIAYATTPAALFVLCLGVAGLLSCLCQYLLLQAVEKTVPELSTQVGAFADKVVDSLQNASAEWANDANGVIGHMSQDLNENVFGWVNTSTTALNDTLNTFVDKTTGVLNDTFGGTLLYEPLMDVFGCLIGLKVQGIQKGLTWVHDHAHIDFPLLPNDTFSRGAAASISSNSSNPSDSFLADAGDQTSNKITEVVIRVVNKVEDGIRTETIISGVIILIWVFIALIGIVRALTLFWVRDRNRGEGGGARVNHHLSDAGGFIDVPLTAVSNTNTDARSMPPPAPAPRYEASTSTVVASRAVPVSSTHHEDEKLGFAGERQYGSALKVDGAADLRGSSYVEYDMEKR
Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.
Q4WQ14
A4QLL4
PSAJ_LOBMA
PSI-J
Lobularia
MRDLKTYLSVAPVLSTLWFGSLAGLLIEINRLFPDALTFPFFSF
May help in the organization of the PsaE and PsaF subunits.
A4QLL4
Q8EH98
RPPH_SHEON
(Di)nucleoside polyphosphate hydrolase
Shewanella
MIDSDGFRANVGIIICNRYGQVMWARRFGQHSWQFPQGGVDDGESAEEAMYRELYEEVGLRPEHVTVLTSTRSWLRYRLPKRLVRQDSKPVCIGQKQKWFLLQLKSQDSAINLSSSGHPEFDDWRWVSYWYPVRQVVSFKRDVYRKVMKEFAVTALSFQTQEIPKKRVRQKTTG
Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage.
Q8EH98
Q01Q48
MURG_SOLUE
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase
Candidatus Solibacter
MTHQQTLPTTAASFLMAGGGTGGHVIPALAVARELRSRGHKVFFVGTQHGMEARLVPPEGFEFKTIEIGGLNQVSWNQKFATLSRLPITTLKCGRSVRDASAVFSMGGYVAGPPVMAALVRRVPVVVMEPNAFPGFTNRVIARLVSRALVSFPETAAFFPKGRTEVTGLPVREEFFRIPPKARGDVLQILITGGSQGSRTLNHAARQSWPLFRNSGYPVRITHQTGTGSFQEIRDAFAQSGLEGEVVPFIADMPAAFAAADLIVCRSGAGTVSELAAAGKPSILVPFPFAADDHQTRNAQSLERAGAARLVRDAEMTGEKFFEVVTSVTGELSRMGTAARQFAKPGAAKRAADILEEVARP
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Q01Q48
Q081G4
CLPS_SHEFN
ATP-dependent Clp protease adapter protein ClpS
Shewanella
MAKLGNVEHIEEKVESELQPPHMYKVVLNNDDYTPMDFVVEVLQRFFEKNEQQAVDIMLAIHNQGKGLCGVFPFGIAETKVFQVNQFARENQHPLLCTLEKV
Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation.
Q081G4
Q6A7V7
BIOB_CUTAK
Biotin synthase
Cutibacterium
MTERGLRGESITREEALEILRSSDDELMSIIAAAGKVRRHFFDNRVRLNYLVNLKSGLCPEDCSYCSQRLGSRAEIMKYSWADPQKVHDAVEAGIAGGARRVCMVASGHGPSRRDVERVNGMVRSLKADHPDVEVCVCLGFVDDEKAASIKEAGADAYNHNANTARSHYGKICSTHSYEDRMDTVEVLKRNGLSPCSGVIAGMGETDEEFVDVIFDLRKHGVDSVPVNFLLPFEGTPLAGGAQHITPQWCLKRLAMVRFAHPDSEVRAAAGREQHIRTMQPLALEVVNSIFLGDYLTSEGAAGAADLQMIEDGGFIPEGADGQPMVHTDVNSHHSANLPVNAVPIRHRGIGTEVPANA
Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.
Q6A7V7
Q493X5
UPPP_BLOPB
Undecaprenyl pyrophosphate phosphatase
Candidatus Blochmannia
MSMIYITLNIIAYVIDVRSLILDVRRLVFSLILGIVEGLTEFLPISSTGHMILVENILNCMDDSVIAFTVIIQLGAILSITKIFWSQLYGMSMICIKKIFFKQHDDHNHLCIRHIFLGTFPGIMLGMIFYEKIGLIFELTYIMYGLIIGGIFLLVGELCASKEPRVSRINNITYLQAFLIGCFQCLAFWPGFSRAGATIGGGLVVGLDRRISSEFSFFLAVPIIFGSAVLTLYHYRSCIGLMDVLLLIAGSATAFFIALFTVRYFLKIVKNVSLIPFAIYRFLLAGGIYWGLMT
Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.
Q493X5
P0CAW7
SECA_CAUVC
Protein translocase subunit SecA
Caulobacter
MLGFAKKLFGSSNERKVKTLATRVAKINAYEAEYAALSDEALKGKTAEFKARLEKGETLDDILNEAFAVVREASKRVLGMRHFDVQMVGGMVLHFSGISEMRTGEGKTLVATLPTYLNALEGKGVHVITVNDYLARRDADWMGQVYNFLGLSYGVIVNGLSQGERQRAYRSDITYGTNNEFGFDYLRDNLVYSVDEMVQRGHNFAIVDEVDSILIDEARTPLIISGPTEDRSSFYKTIDVLVKELILDKSMFDHDEKQKQVILTEDGQEKIEEILMSGGHLAEDSAGLYDAANVSVVHHVNQALRANILYTRDKDYIVKGGEVVLIDEFTGRMMTGRRLSEGLHQAIEAKEGADIQPENQTLASVTIQNYFRLYKKLSGMTGTASTEAQEFDDIYKMSVSEIPTNRTIQRIDDDDEVYRTEREKNEAILKQIADCHVRGQPILVGTVSIEKSEELSKLLSTFSFEKDGKKVKGIPHQVLNARFHEQEAVIVADAGVPGAVTIATNMAGRGTDIQLGGSIDMRLFNWRQQQRGMGLEITVEDEAEERARLETEIADKKAQALAAGGLFVLGTERHESRRIDNQLRGRTGRQGDPGRSKFFLSCEDDLLRIFAGERLDAIMRTFGVQEGEAITHKWLNNAIATAQKRVEQRNYEIRKNLLKYDDVVNDQRKAVFEQRQEFMESSDLSDIIHEMRRDVIDDLVLRHLPPKAYAEQWDVEGLTERVKSILGLDLPIAEWAAEEGIADEEMKERITKAADEYAAQREVIITPEQMRSVEKSFLLQMIDLQWREHLMHLDHLRNVIGLRGYGQRDPLNEYKTEAFSLFEKLLGDLRTNTTRWLMTVEIAYAEPEVPHTPLDNLVEVHLDPLTGENAAFAGGIPEGLSTAQREALPVSALPEGWDRTNRNAPCPCGSGKKFKQCHGSLVR
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
P0CAW7
A9M4L8
MUTS_NEIM0
DNA mismatch repair protein MutS
Neisseria
MSKSAVSPMMQQYLGIKAQHTDKLVFYRMGDFYEMFFDDAVEAAKLLDITLTTRGQMDGVPIKMAGVPFHAAEQYLARLVKLGKSVAICEQVGEVGAGKGPVERKVVRIVTPGTLTDSALLEDKETNRIVAVSPDKKYIGLAWASLQSGEFKTKLTTVDKLDDELARLQAAEILLPDSKNTPQLQTASGVTRLNAWQFAADAGEKLLTEYFGCQDLRGFGLDGKEHAVAIGAAGALLNYIRLTQNLMPQHLDGLSLETDSQYIGMDAATRRNLEITQTLSGKKSPTLMSTLDLCATHMGSRLLALWLHHPLRNRAHIRARQEAVAALESQYKPLQCRLKNIADIERIAARIAVGNARPRDLAALRDSLFALSEIDLSANGSSLLETLKAVFPETLPVAETLKAAVMPEPAVWLKDGNVINHGFHPELDELRRIQNHGDEFLLDLEAKERERTGLSTLKVEFNRVHGFYIELSKTQAEQAPADYQRRQTLKNAERFITPELKAFEDKVMTAQEQALALEKQLFDGVLKNLQTALPQLQKAAKAAAALDVLSTFSALAKERNFVRPEFADYPVIHIENGRHPVVEQQVRHFTANHTNLDHKHRLMLLTGPNMGGKSTYMRQVALIVLLAHTGCFVPADAATIGPIDQIFTRIGASDDLASNRSTFMVEMSETAYILHHATEQSLVLMDEVGRGTSTFDGLALAHAVAEHLLQKNKSFSLFATHYFELTKLPEAHATAVNMHLSALEQGQDIVFLHHIEPGPASKSYGIAVAKLAGLPVRALKSAQKHLNELEDQAAANRPQLDIFSTMPSEKGDEPNVDSFVDKAEEKHFEGILAAALEKLDPDSLTPREALSELYRLKDLCKSVS
This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.
A9M4L8
A7HP87
CAS2_PARL1
CRISPR-associated endoribonuclease Cas2
Parvibaculum
MWVIAMFDLPTDTPKARKAYARFRKDLLEDGFTMMQYSVYSRHCASIENAEVHVKRMGAVVPAQGEVRFLTITDNQFGRIKVYVGKKRQPTTQSPSQLQLF
CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
A7HP87
A4JPG9
HCP_BURVG
Prismane protein
Burkholderia cepacia complex
MFCYQCEQTDRTGARPGCATAKGNCGKDETTADLQDLLIHAVKGIAQYGALARTMGVRDREADRFVLYAMFTTLTNVNFHAARFVALLREAAQTRDRVKAACDAQARATGAALPALQGPAAWQPADDLPGLLKQAAAVGIDAGLDTVGADIVGLRALVLYGLKGVCAYAHHARVLGYERDDIYEGIEAALAFLATDPTDVNALLEQALDLGRLNLTVMELLDSANTGRFGAQQPSAVRVSPVAGKAILVSGHDLGDLHALLEQTAGTGINVYTHGEMLPAHAYPALNAFPHLVGNYGGAWQDQQSDFAHFPGPILMTSNCIIEPLPQYRQRIFTTGPVGWPGVRHLEHHDFSTLIRAAQALPGFPATAPEETITVGFGRHAVLGVADKVIDAVKAGQIRHFFLIGGCDGAAPGRNYYTEFAEQAPDDTVVMTLGCNKYRFNRHAFGDIGGIPRLLDVGQCNDSYSAIRIATALADAFECGVNDLPLSLVISWFEQKAAAVLLTLLALGIRNIRLGPTLPAFITPGVLNVLVDQFGIQPIGDASADLAAALSRQAA
Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
A4JPG9
C7MWX8
MSHC_SACVD
Mycothiol ligase
Saccharomonospora
MQTWSSVAVPRVPGTSRPLRLYDTATGQIRPTAPGRVAKMYVCGITPYDATHLGHAATYLAFDLVHRLWLDAGHEVHYVQNVTDIDDPLLERAERDSEDWVVLGLRETALFREDMEALRVLPPRDFVGAVESIPEVVEMIEKLLASGAAYRVDDPEYPDVYFDRSFTGRFGYESNYDDETMRAIFPERGGDPDRPGKRDPLDALLWRVERPGEPAWDSSLGRGRPGWHIECSAIALKHLGIGFDVQGGGSDLVFPHHEFSAAHAEAMTGEHPFARHYVHAGMIGLDGEKMSKSKGNLVFVSRLRADDVDPSAIRLALFAGHYRDDREWTDELLKQANSRLARWREAVSLPSGPDAEATVDRLRDHLADDLDTPKALAAVDAWVDEALRHRSGTVGSESAPALVRAAVDSLLGVVL
Catalyzes the ATP-dependent condensation of GlcN-Ins and L-cysteine to form L-Cys-GlcN-Ins.
C7MWX8
P44399
FUCK_HAEIN
L-fuculose kinase
Haemophilus
MAIALIFDCGATNLRTIAINEKGQILASHHLANNTKQGIESSDYHIWDIEEIWQKLTSCATQTLNQLMQQGIDLKDIVGISVTTFGVDGAPFDENDQQLYPIISWKCPRTIPVMENLSNQLDIKSLYQRNGIGQYSFNTLFKLHWLKTHKPDVFQKMAKFVFISSMLTQRLTGQFTTDHTMAGTSMMTNLTSGNWDPSILASLGLSNNHFPPMRYAGEKVGKLRTPLAQKWGLNPVPVISCGHDTQFAVFGSGAGLNQPVLSSGTWEILMARTQHAEPRFEFVSQGLTTEFDAQSNCFNPAVQWVGSGVIEWLGKLLFSDVYGSDHYYTTMIKEGEKAFNAGKRAVNFEGIFSQLGQGNISGLSMFATRGEIYVSALQHMANKLKNGLSVLHQVSQFQAKSLICVGGGSKNVLWNQIRANTLNLPIDVVDISESTVLGAAMFTFAGVGIYENVNAAQQAMQPTRKRIYPN
Catalyzes the phosphorylation of L-fuculose.
P44399
Q6D6A4
TRHO_PECAS
tRNA hydroxylation protein O
Pectobacterium
MPVLHNRVSNEELKARMLAETEPRTTVSFYKYFTIDDPKAFRDRLYIQLEQYKVFGRIYIAAEGINAQISVPNNQFDAFKTGLFSAHPALDQIRLNIALEDDGKSFWVLRMKVRERIVADGIDDPTFNPANVGQYLKADRVNAMADDPDTVFVDMRNHYEYEVGHFQNALEVPSDTFREQLPMAVDMLDDIRDKNIVMYCTGGIRCEKASAYMLHHGFKNVYHVEGGIIEYARQAKAQGLPLKFIGKNFVFDERMGERISDDVIAHCHQCGASCDSHTNCRNEGCHLLFIQCPSCAAKYEGCCSTQCQDEMKLPLEEQRAIRSGRENGMKIFNKSKGLLQSTLHIPAPAAKDNAE
Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs.
Q6D6A4
Q15R07
ISPH_PSEA6
4-hydroxy-3-methylbut-2-enyl diphosphate reductase
Pseudoalteromonas
MQIHLANPRGFCAGVDRAITIVERALEIFSPPIYVRHEVVHNKFVVDGLKERGAVFVDELVEVPDDSIVIFSAHGVSQAVRNEASSRGLKVFDATCPLVTKVHMEVMRASSKGTECVLIGHQGHPEVEGTMGQYDNQDGGIYLVESVDDVARLEVKNPSALYYCSQTTLSVDDTADVIDALRAKFPAIEGPRKDDICYATQNRQDSVRELSADCDILLVVGAQNSSNSNRLRELAEKIGAKAHLIADANCIQKEWLANAKHIGVTAGASAPEVLVQGVVDRLKEWGASSATERPGRLENIEFAVPKELRVKQVS
Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.
Q15R07
Q9UGP5
DPOLL_HUMAN
DNA polymerase kappa
Homo
MDPRGILKAFPKRQKIHADASSKVLAKIPRREEGEEAEEWLSSLRAHVVRTGIGRARAELFEKQIVQHGGQLCPAQGPGVTHIVVDEGMDYERALRLLRLPQLPPGAQLVKSAWLSLCLQERRLVDVAGFSIFIPSRYLDHPQPSKAEQDASIPPGTHEALLQTALSPPPPPTRPVSPPQKAKEAPNTQAQPISDDEASDGEETQVSAADLEALISGHYPTSLEGDCEPSPAPAVLDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
DNA polymerase that functions in several pathways of DNA repair . Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA . Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination . Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities . Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity .
Q9UGP5
Q99JY0
ECHB_MOUSE
Beta-ketothiolase
Mus
MTTILTSTFRNLSTTSKWALRSSIRPLSCSSQLHSAPAVQTKSKKTLAKPNMKNIVVVEGVRIPFLLSGTSYKDLMPHDLARAALSGLLHRTNIPKDVVDYIIFGTVIQEVKTSNVAREAALGAGFSDKTPAHTVTMACISSNQAMTTAVGLIASGQCDVVVAGGVELMSDVPIRHSRNMRKMMLDLNKAKTLGQRLSLLSKFRLNFLSPELPAVAEFSTNETMGHSADRLAAAFAVSRMEQDEYALRSHSLAKKAQDEGHLSDIVPFKVPGKDTVTKDNGIRPSSLEQMAKLKPAFIKPYGTVTAANSSFLTDGASAMLIMSEDRALAMGYKPKAYLRDFIYVSQDPKDQLLLGPTYATPKVLEKAGLTMNDIDAFEFHEAFSGQILANFKAMDSDWFAQNYMGRKTKVGSPPLEKFNIWGGSLSLGHPFGATGCRLVMAAANRLRKDGGQYALVAACAAGGQGHAMIVEAYPK
Mitochondrial trifunctional enzyme catalyzes the last three of the four reactions of the mitochondrial beta-oxidation pathway. The mitochondrial beta-oxidation pathway is the major energy-producing process in tissues and is performed through four consecutive reactions breaking down fatty acids into acetyl-CoA. Among the enzymes involved in this pathway, the trifunctional enzyme exhibits specificity for long-chain fatty acids. Mitochondrial trifunctional enzyme is a heterotetrameric complex composed of two proteins, the trifunctional enzyme subunit alpha/HADHA carries the 2,3-enoyl-CoA hydratase and the 3-hydroxyacyl-CoA dehydrogenase activities, while the trifunctional enzyme subunit beta/HADHB described here bears the 3-ketoacyl-CoA thiolase activity.
Q99JY0
Q83GG2
ISPT2_TROWT
Isoprenyl transferase 2
Tropheryma
MGGKMLRSVSELIYKVYARYLLGQINLNNLPGHVALIVDGNRRWARKEKRDRISDGHRAGAGKAVDFLHWCDELDINIVTLYLLSNDNLKNRNRQELNDLVQVICDLIAQVSKRWKVNHVGSCENLPELLGNSLEGVKSSTKTNRYSERSMTVNLAIGYSGRAEITEAVRKIVNTYPIGDLPEKITEEVISANLYTGGLSDPDLIIRTSGEQRLSDFMPWQSTHSEFYFLEALGPDLRKVDFLRAIRDFSIRRRSFGA
Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
Q83GG2
B1NWH0
PSAJ_MANES
PSI-J
Manihot
MRDLKTYLSVAPVISTLWFGSLAGLLIEINRFFPDALTFPFFSF
May help in the organization of the PsaE and PsaF subunits.
B1NWH0
Q112X4
THIG_TRIEI
Thiazole synthase
Trichodesmium
MQTVEKLTTETLEKPLIIAGKKFTSRLMTGTGKYPTIETMQQSIEASKCEIITVAVRRVQTQAPGHKGLAEAIDWQKVWMLPNTAGCQTAEDAVRVARLGREMAKLLGQEDNNFVKLEVIPDSKYLLPDPIGTLQAAEQLIKEGFAVLPYINADPLLAKRLEEAGCSTVMPLGSPIGSGQGIQNAANISIIIDNSTVPVVIDAGIGTPSEATQAMEMGADALLINSAIALAKNPPIMAKAMGMATESGRLAYLAGRIPKKSYATPSSPVTGKINTTTSE
Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
Q112X4
Q5LBD7
HIS6_BACFN
ImGP synthase subunit HisF
Bacteroides
MLAKRIIPCLDIKDGQTVKGTNFVNLRQAGDPVELGRAYSEQGADELVFLDITASHEGRKTFAELVRRIAANISIPFTVGGGINELSDVDRLLNAGADKISINSSAIRNPQLIDDIAKHFGSQVCVLAVDARQTGNGWKCYLNGGRIETDKELRTWTKEAQERGAGEVLFTSMNHDGVKTGYANEALAELASQLSIPVIASGGAGRMEHFRDAFTLGKADAALAASVFHFGEIKIPELKSYLCGQGITVR
IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
Q5LBD7
Q0KBK5
TIG_CUPNH
PPIase
Cupriavidus
MSNVIENLGKLDRKVTLAIPKAEVEKEKQERLVRLSKTVKMSGFRPGKVPMKMVEKQYGQQVEFEVRFDKAARKFFDITKEQDVKVAGQPKFEIKNEGVGEDEVAFDATFEVYPEVTIGDLSAAEVTRTGTEITDAEVDKTIDILRKQRVHYHARGEAGEHGDGGADVAAQNGDRVTLDFVGKIDGEEFAGGKAEDFPFVLGEGRMLPEFEQAALGLKVGESKTFPLAFPEDYHGKEVAGKTAEFTVTLKKIEWAHLPEVNDAFAKSLGIADGSVEKMRADIRENLEREVKRRTHSMLKDQVMEALLKASELEVPKALIEQDQERLVEMARRDLEQRGMPNAKDMPIPAEMFAQQAERRVKLGLILAEIVKANGLEAKADQIKAEIEDFAKSYEDPKEVMRWYYGDQQRLAEMEAYVLENNVVNFVCGKAKVTDKKVSFEELTAEGNQQQA
Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.
Q0KBK5
A1SF35
ACPS_NOCSJ
4'-phosphopantetheinyl transferase AcpS
Nocardioides
MIVGVGIDVVDVARFGVSLSRTPGLTDRLFTPEEAERPLASLAARFAAKEALAKALGAPEGMHWHDAEIRSEESGRPVFEIRGSVLRRANDLGVGSVHVSLSHDAGIASAVVVLES
Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.
A1SF35
Q3KFL8
MINC_PSEPF
Probable septum site-determining protein MinC
Pseudomonas
MSQTEPKDQDPVFQLKGSMLAITVLELSRNDLDSLDRQLAAKVAQAPNFFSNAPLVLALDKLPPSEGAVDLPGLMRVCRQHGLRTLAIRASRIEDIAAAIAIDIPVLPPSGARERPLESAEPVAPKKPEKPPEPTVKPTRVITTPVRGGQQIYAQGGDLVVVSSVSPGAELLADGNIHVYGPMRGRALAGVKGDTKARIFCQQLSAELISIAGHYKVSEDLRRDPMWGSGVQVSLSGDVLNIIRL
Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization.
Q3KFL8
Q6X632
GPR75_MOUSE
Probable G-protein coupled receptor 75
Mus
MNTSAPLQNVPNATLLNMPPLHGGNSTSLQEGLRDFIHTATLVTCTFLLAIIFCLGSYGNFIVFLSFFDPSFRKFRTNFDFMILNLSFCDLFICGVTAPMFTFVLFFSSASSIPDSFCFTFHLTSSGFVIMSLKMVAVIALHRLRMVMGKQPNCTASFSCILLLTLLLWATSFTLATLATLRTNKSHLCLPMSSLMDGEGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVKKCPPVITVDASRPQPFMGASVKGNGDPIQCTMPALYRNQNYNKLQHSQTHGYTKNINQMPIPSASRLQLVSAINFSTAKDSKAVVTCVVIVLSVLVCCLPLGISLVQMVLSDNGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLRYTGLGFLCCKQKTRLRAMGKGNLEINRNKSSHHETNSAYMLSPKPQRKFVDQACGPSHSKESAASPKVSAGHQPCGQSSSTPINTRIEPYYSIYNSSPSQQESGPANLPPVNSFGFASSYIAMHYYTTNDLMQEYDSTSAKQIPIPSV
G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor.
Q6X632
A1ALM1
KUP_PELPD
Probable potassium transport system protein kup
Pelobacter
MKHGETDSYWGGIIKSMGLVFGDIGTSPIYTLTVIIALTKPTQDNILGIISLIVWTLIILVHLEYAVLAMSLSRKGEGGEIVLREILVRMIKPGRQMAFVTFLTYLGVALLMGDGVITPAISILSAVEGTLLIPGLGGLSQNTLILIAGTIALFLFVFQYKGTDKVARAFGPIMVLWFAALALSGAISVSSHPGILAAISPHHAISFLMHNGLPGFFVLSEVILCATGGEALYADMGHLGRKPVKRAWYFVFVALVINYLGQGAFIITHPDAKNILFGMLQYQAPLFYIPFLILTILATIIASQALISGVFSIVYQGINTRMLPLLKVDYTSNQLKSQIYIGSVNWLLLCLVILIMLVFRKSANLAAAYGFAVTGTMVITGIMMTMIFSRTTKKWKVPLALFVTLVDVVFLVSNCNKLPHGGYWSLILASVPLAVILIWTRGQRGLYLALRPLDLETYLLSYEQIYKKGRIAGTGLFFVKEWNIIPPYLVHCTIRSNIVYERNVLISIVRTDEPFGVESVLECGIGTGLDGFMIKAGYMEIFDIELLLKQNGIQEKVIFYGIEDIATTNPIWRVFSVIKKLTPNFVQFNKVPAAKLQGVITRVEM
Transport of potassium into the cell.
A1ALM1
B2HIH1
LEU3_MYCMM
Beta-IPM dehydrogenase
Mycobacterium
MKLAIVAGDGIGPEVVAQAVKVLDVVQPGVEKTNYDLGARRFHATGEILPDSVIAELREHDAILLGAIGDPSVPSGVLERGLLLRLRFELDHHINLRPGRLYPGVKSPLALEPGNPEIDFVVVREGTEGPYTGNGGAIRVGTANEVATEVSVNTAFGVRRVVRDAFERAMRRRKHLTLVHKNNVLTFAGSLWWRTVQEIGEEYPDVELAYQHVDAATIHMVTDPGRFDVIVTDNLFGDIITDLAAAVCGGIGLAASGNIDATRTNPSMFEPVHGSAPDIAGQGIADPTAAIMSVSLLLAHLGLDDAASRVDRAVEGYLATRGNERLATAAVGERIAAAL
Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
B2HIH1
Q31YR1
CBPA_SHIBS
Curved DNA-binding protein
Shigella
MELKDYYAIMGVKPTDDLKTIKTAYRRLARKYHPDVSKEPDAEARFKEVAEAWEVLSDEQRRAEYDQMWQHRNDPQFNRQFHHGDGQSFNAEDFDDIFSSIFGQHARQSRQRPAARGHDIEIEVAVFLEETLTEHKRTISYNLPVYNAFGMIEQEIPKTLNVKIPAGVGNGQRIRLKGQGTPGENGGPNGDLWLVIHIAPHPLFDIVGQDLEIVVPVSPWEAALGAKVTVPTLKESILLTIPPGSQAGQRLRVKGKGLVSKKQTGDLYAVLKIVMPPKPDENTAALWQQLADAQSSFDPRKDWGKA
DNA-binding protein that preferentially recognizes a curved DNA sequence. It is probably a functional analog of DnaJ; displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity; binds native substrates and targets them for recognition by DnaK. Its activity is inhibited by the binding of CbpM.
Q31YR1
A9VQ50
TPIS_BACMK
Triose-phosphate isomerase
Bacillus cereus group
MRKPIIAGNWKMNKTLAEAVSFVEEVKGQIPAASAVDAVVCSPALFLERLVAKAEGTDLQVGAQNMHFEKNGAFTGEISPVALSDLKVGYVVLGHSERREMFAETDESVNKKTLAAFEHGLTPIVCCGETLEERESGKTFDLVAGQVTKALAGLTEEQVKVTVIAYEPIWAIGTGKSSSSADANEVCAHIRKVVAEAVSPEAAEAVRIQYGGSVKPENIKEYMAQSDIDGALVGGASLEPASFLGLLGAVK
Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).
A9VQ50
Q49XF7
RBSD_STAS1
D-ribose pyranase
Staphylococcus
MYKTGILNSDISKLLSDLGHTDEIMIADCGLPIPNGVKKIDLALDFGKPSFLDVFHIVKSHMAIEKMTLASEMKTENESLYNVLKEEEIKFTTESHELLKQHSKHVKAIIRTGEAKPYANVILASDVLF
Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.
Q49XF7
Q5JDB6
TRUD_THEKO
tRNA-uridine isomerase D
Thermococcus
MDYREFFSQFKHLSEKPGIGGKIKIYPEDFIVIEEPIPSIFEGRKYAIFLLKKRNWETMAAVKEIAKRAGINYREIGFAGTKDRHAVTYQYISVPAEARERVEQVSIRDIELRFVSYGRFIKLGHLLGNRFRIIVRDVSEDAFDRTKEIVRELREKGGFPNYFGYQRFGERRVVNHIIGKLLLQGDFEGAARLFLGAHDGSMEGDEARKNFWETGDVERALEEFPGFLRYERTLLHRYKDTGNWKRAFLSLPLPIMRIFIHAYQSYLFNLYLSRRIEEGLPLNEPLVGDIVVQVKGGIPYRDRTYRVTETNLEFVREKVRKNQAMVSGPLFGFAMRRAKGLPGELEKEILEEEGLSLETFRRLPKPMAEPGGRRELLLRPMGMAYGYIQEEGMCFRFFLPKGTYATSVLREIMKDH
Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.
Q5JDB6
Q8KBZ7
HPRK_CHLTE
HPr(Ser) kinase/phosphorylase
Chlorobaculum
MNFDQKGLKKRSITVAYFFEHIQKRFDIKFRRLNELDEQKCRIHERDLHRPGLAIAGFTKLFTYKRVQILGNTETRYLNHLSDEERKTAFANFVSFRMPCIILTSNNKLDQELVDMATGAGIPVFITRCSSTKTIYYITDFLDEEFSLYQQYHGSMIDVYGVGVLLTGKSGLGKSEVALDLIERGHGLVADDVVVVKRKGETKTLVASRNNIIDHFMEIRGLGVVDVRQNFGIRAIRDRKEVQVVVELLEWSKESEYERLGLDQKMVKLLGVDLPLVQLPIFPGKNITAIIEVVALNFLLKHYAGYVPAEALTERIRNVINKERAKAPAPSTSFEEYNDEND
Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).
Q8KBZ7
A9BMV7
NDK_DELAS
Nucleoside-2-P kinase
Delftia
MAIERTLSIIKPDAVAKNVIGQIYARFEGAGLKVIAAKMVHLSRGEAEQFYGVHKERPFFKDLVDFMVSGPVMIQALEGENAILKNRELMGATDPKKAEKGTIRADFADSIDANAVHGSDAAETAAVEVAFFFPGMNVYSR
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
A9BMV7
A6LF29
ISPF_PARD8
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Parabacteroides
MKIRVGFGYDVHALVPDRELWLGGIKIEHTLGLLGHSDADVLIHAICDALLGAANMRDIGYHFPDTAGEYKNIDSKILLRDTMRLLREAGYELGNIDATVAAERPKLNPHIPLMKKTLAEVMNVDEEDISIKATTTEKLGFTGRQEGISAYATVLIQRMGS
Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
A6LF29
B4UDT1
RPOC_ANASK
Transcriptase subunit beta'
unclassified Anaeromyxobacter
MKDIFNFFEKPKDPLSFSAIRISLASPDKIRQWSHGEVKKPETINYRTFKPERDGLFCAKIFGPVKDYECNCGKYKRMKHRGVVCEKCGVEVIQSKVRRERLGHITLATPVAHIWFLKSLPSRIGNLLDITLKDLEKVLYCESYIVIDPKETTFQRGELLSEDRYQKALDEFGDDAFSAGMGGEAVLGLLRGVGPASKEHGEGIPGLANELRAEMKEATSDAKRKKIAKRLKVVEAFVASGNKPEWMMLEVIPVIPPDLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLQELNAPDIIIRNEKRMLQEAVDALFDNGRRGKTITGPNKRPLKSLSDMLKGKQGRFRQNLLGKRVDYSGRSVIVVGPELKLHQCGLPKIMALELFKPFIYNKLEEKGYVTTIKSAKKMVEKERPEVWDILDEVIREHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCTAFNADFDGDQMAVHVPLSIEAQMEARVLMMSTNNILSPAHGKPIIVPSQDIVLGIYYMTRERAFARGEGKVFASPEEVRAAYDQGEVDLQAKVWVRMDGKRVETTVGRVLLYDIVPRRLSFESINKVMDKKQLQGLIDLTYRLCGEKETVLLADRVRSMGYGNATRAGISIALDNMVIPRKKVDLLERATREVDDIQAQYTEGLITIGERYNKVIDIWAQVTEEVAQEMMGEIGTETAVGTGKDGKREERRQPSFNPIYIMADSGARGSAQQIRQLAGMRGLMAKPSGEIIETPITANFREGLNVLQYFISTHGARKGLADTALKTANSGYLTRRLVDVAQDAIITEYDCGAMDGITLGALVEGGEIIEPMGERILGRVALDDMLDPFSGNVLVKANEEIDEGKVKLIENAGIDKVKIRSVLTCQARRGICVECYGRDLARGRKVNIGEAVGVIAAQSIGEPGTQLTMRTFHIGGAASRRAEQSTIENRNAGLIKFNNVSVAKKRDGTLIVMNRNGEIIVTDDQGRERERYGVVYGAKLLVREGQKVEANQLLAEWDPYSMPIITEVAGRVKYGDLVDGVTISEQVDEITGLARKAVIASKDPDARPRISIKDEEGRTKKLANSDADARYMLPEGANLVVNDGDEVDAGDVIAKMPRETTKTKDITGGLPRVAELFEARKPKEHAVISEIDGVVAFGKDTKGKRKVVITPEVDSKLRPDLAKEYLIGKGKHISVHTGDRVRAGEALMDGAANPHDILRVLGEKELARWLVDEVQEVYRLQGVKINDKHIETIVRQMLRRVRIVDVGDTEFLADEQVEKFAFEEENERVLKAGGRAAQGEPLLLGITKASLSTESFISASSFQETTKVLTEAAISGKVDYLRGLKENVIMGRLVPAGTGLGAYKHLDIEVETPVDAVEEAEEALAVGAEE
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
B4UDT1
Q8DPV9
AGGDS_STRR6
Alpha-galactosylglucosyldiacylglycerol synthase
Streptococcus
MRKFPLFSSSLSFLLLILFKENDIIVVMEKKKLRINMLSSSEKVAGQGVSGAYRELVRLLHRAAKDQLIVTENLPIEADVTHFHTIDFPYYLSTFQKKRSGRKIGYVHFLPATLEGSLKIPFFLKGIVKRYVFSFYNRMEHLVVVNPMFIEDLVAAGIPREKVTYIPNFVNKEKWHPLPQEEVVRLRTDLGLSDNQFIVVGAGQVQKRKGIDDFIRLAEELPQITFIWAGGFSFGGMTDGYEHYKTIMENPPKNLIFPGIVSPERMRELYALADLFLLPSYNELFPMTILEAASCEAPIMLRDLDLYKVILEGNYRATAGREEMKEAILEYQANPAVLKDLKEKAKNISREYSEEHLLQIWLDFYEKQAALGRK
Galactosyltransferase involved in the biosynthesis of the bilayer-forming membrane lipid alpha-galactosyl-glucosyldiacylglycerol which is involved in maintaining constant nonbilayer/bilayer conditions (curvature packing stress). Also involved in the beta-lactam resistance. Catalyzes the transfer of a galactosyl residue from UDP-Gal to alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn-glycerol) acceptor to form the corresponding galactosyl-glycosyl-DAG product (3-O-alpha-(D-galactopyranosyl-alpha-(1->2)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol). It can only use UDP-Gal as sugar donor and alpha-glucosyl-DAG is the preferred sugar acceptor.
Q8DPV9
A3N3Q5
SLMA_ACTP2
Nucleoid occlusion factor SlmA
Actinobacillus
MIQPTVKMPKKSVKERQQQVLEVLIGLLNSEDGMQRVTTERLAKAVGVSEGALYRYFPSKTKMFEALIERIEQTLTGYINASKRKENTTASTVKAILYTVIEFARKNPGVTRILTGHALMFEDDQLKARVAKFFDGLEFQFANILQMSKLREGKTFEDERALAGYLVNFCEGQFLRLVRSNFSYNQHQHFEKQWALIKPLFE
Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions.
A3N3Q5
Q8KAJ0
RL15_CHLTE
50S ribosomal protein L15
Chlorobaculum
MDLSSLRPAKGAVKARKRVGRGPGSGNGTTAGKGNKGQQSRSGYQRPVIEGGQMPIYRRLPKFGFTPPNQKAVACVNVAQIQMWIEKGLVGEEISVLDLKHLCNASNQEYFKVLGNGELTSTVTITAHFFSKSAEEKIAKAGGKIVKAYRTLEEAAKVNGLPFEEALLTPKAKVVKVKKEKKSVKS
Binds to the 23S rRNA.
Q8KAJ0
P57962
DAPF_PASMU
PLP-independent amino acid racemase
Pasteurella
MQFSKMHGLGNDFVVVDAITQNLYFSPETIKRLADRHRGIGFDQMLIVEPPYDPDLDFHYRIFNADGSEVSQCGNGARCFARFVTLKGLTDKKDIAVSTQTGKMILSIKDDGMIRINMGEPIWEPAKIPFTANKFEKNYILRTSIQTVLCGAVSMGNPHCVVQVDDIQTANVEQLGPLLENHERFPERVNAGFMQVIHRGHIKLRVYERGAGETQACGSGACAAVAVGVMQGLLDSKVQVDLPGGSLIIEWEGVGKPLFMTGDATHVYDGVIRL
Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.
P57962
B0U083
RLMN_FRAP2
tRNA m2A37 methyltransferase
Francisella
MQQDKINLLGLNQKAIEDFFISIGEKKFHARQVFKWIHKKGVIDFDSMTDLGKNLRNKLKENAEIVIPKVVFNKASKDGTHKWLIDVGGSAVETVFIPEEGRGTLCVSSQVGCTLNCSFCSTGKQGFNRNLSSAEVISQLWIAARTLSKNNGEHDFSVTNIVMMGMGEPLMNFENVVPAMDIMMDDLAYGLSRRKVTLSTSGVVPRIYDLLEQSGVSLAVSLHAPTDSLRNEIVPINKKYNIDELLEACKLYAEKGPHKHITFEYTLMEEVNDNLSDAEQLIELLRSREVPAKINLIPFNPYPGTPYRKPSNNRIHRFKEFLQHNGFVTTVRKTRGDDIDAACGQLAGDVMDKTKRKERYLKKLGDKNAI
Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.
B0U083
Q8EER0
CRCB_SHEON
Putative fluoride ion transporter CrcB
Shewanella
MNNLLLVALGGSIGAVFRYLISIFMIQVFGSSFPFGTLLVNVLGSFLMGVIYALGQMSHISPEFKALIGVGLLGALTTFSTFSNETLLLMQEGDWLKAALNVVLNLSLCLFMVYLGQQLVFSRI
Important for reducing fluoride concentration in the cell, thus reducing its toxicity.
Q8EER0
Q47B65
PANC_DECAR
Pantoate-activating enzyme
Dechloromonas
MQIHSSIADLRSALKNRGRVVFVPTMGNLHAGHISLMTQARAHGDTVVASIFVNRLQFGPNEDFDKYPRTFQADCDKLAAAGVDVLFAPTEADLYPEPQEYTVEPPAIQNILDGEFRPGHFRGVATVVLKLFNCVQPQAAMFGKKDYQQLMVIRNMTRQLALPIDIIGGETVRAEDGLALSSRNGYLSAAERTEAPRLYRLLNEIRAAIRAGETDTVKLENEAIAALTAAGWKNDYVAVRQQSDLSMPKGVNAPLVALAASRLGSTRLIDNIEI
Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.
Q47B65
Q1BLY7
DXS_BURCA
1-deoxyxylulose-5-phosphate synthase
Burkholderia cepacia complex
MYDLLKTIDDPADLRRLDRRQLQPLADELRAFVLDSVSKTGGHLSSNLGTVELTIALHYVFNTPNDRIVWDVGHQTYPHKILTGRRDQMHSLRQYDGISGFPRRSESEYDTFGTAHSSTSISAALGMAIGSQLNGDDRFSIAVIGDGAMTAGMAFEAMNNAGVSEDAKLLVILNDNDMSISPPVGALNRHLARLMSGRFYAAARAGVERVLSVAPPVLELARKLEEHAKGMVVPATLFEEFGFNYIGPIDGHDLDSLIPTLQNIRELRGPQFLHVVTKKGQGYKLAEADPVLYHGPGKFNPAEGIKPSTTPAKKTYTQVFGEWLCDEAERDTRVVGITPAMREGSGMVEFEKRFKDRYYDVGIAEQHAVTFAGGLATEGLKPVVAIYSTFLQRAYDQLIHDVALQNLPVVFAIDRAGLVGADGATHAGAYDLAFMRCIPNMTIMAASDENECRQMLHTALQQPNPTAVRYPRGAGTGVATVKEFTEIPLGKGEVRRRTSQPEGKRVAILAFGTMVAPSLAAAEELDATVANMRFVKPVDAALVRELAETHDYLVTVEEGCVMGGAGSACVEALMESGVIRPVLQLGLPDQFVDHGDHAKLLAQCGLDGAGIAKSIRERFLSPAADVAGHAKRVA
Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).
Q1BLY7
Q2RM68
RL9_MOOTA
50S ribosomal protein L9
Moorella
MKVILTADVAKLGNRGTLVEVSEGYARNYLLPRGLAVEATAGRLKELDLEKKRREKKENQELENARRQAARLDGAVVKITTRAGETGKLFGSVTNKEIAEAIKNTFQISLDRRKIDLKEPIKALGSYEVTLKLHPTVQAHLRVQVVAEGS
Binds to the 23S rRNA.
Q2RM68
Q03523
MURE_BACSU
UDP-N-acetylmuramyl-tripeptide synthetase
Bacillus
MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVKGYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKLQLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQKTFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAKSLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISITAQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVRGRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKMAKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKKGDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS
Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.
Q03523
A1E9I7
ATPF_HORVU
ATPase subunit I
Hordeum
MKNVTHSFVFLAHWPSAGSFGLNTDILATNLINLTVVVGVLIFFGKGVLKDLLDNRKQRILSTIRNSEELRRGTIEQLEKARIRLQKVELEADEYRMNGYSEIEREKANLINATSISLEQLEKSKNETLYFEKQRAMNQVRQRVFQQAVQGALGTLNSCLNTELHFRTIRANIGILGSLEWKR
Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).
A1E9I7
C1L2I5
XERC_LISMC
Tyrosine recombinase XerC
Listeria
MIQEGKLEQQFFDYLHSERNYSVNTSTAYENDLLDFRRFLNEQAITTYQQVTFLDVRIYLTELKQKSFSRTTVARKISSLRSFYTFLLRENVINENPFTYVSHAKNQLRLPKFFYSEEMEALFQVVYEDNETLTLRDRVLLEVLYGTGIRVSECAGILLPDLDTSYQAILIRGKGNKERYVPFGVYAEDAITDYLPERANLMSRYKKSHDALLVNHYGDPLTTRGIRYCLSKIISKASLTRKIHPHMLRHTFATDLLNNGADMRTVQELLGHASLSSTQIYTHVTKEHLKSTYMKHHPRA
Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
C1L2I5
O74832
PT127_SCHPO
mRNA degradation protein pet127, mitochondrial
Schizosaccharomyces
MLIYKKKNFGRRSVYNLKKCLHKGFQINSCNIKAADNVLHSKASAFEKVNVVDKESIGNLQHHLDTVLPKKKFQFLRDPKTNDYKWDEYLSKILPVDKFNFGLLSKFRPPSEDEQLQKVANSIGAEFVGSTSSLTGLMSQLHFFISKWKFPNFSDLSKGFYISPNERNFTRLCRSASSVHISYQNGLYCIDKDKSLTKEPSVNIILMNVGKSLETFFTVDKDQFLLYKKPPSSNGVLKPLKDVFQYGRCSSLLVRSQLDCYDKKIPESGVFDLKTRAVFGVRMNQTQPELFKSYKLTHYYGNRISFEREYFDLIRSAFMKYSLQARLGYMQGVFVAYHNTSDIFGFQYIPLVAMDRAIHGSSEIGEAEFNLNLQLLEKILQYATSIFPKRSFRVMLSTTEDVPNPPLKVYLEVADDKENRGFDLLDGQKNLEAKTVSPSNFCALEVCALQFVNGVHKSVVKHLDEKETWSIKYHFRKPRDQDNLLRNYIRLRDDIKRRESKISNPPESLLHDYYACSEQYYKRN
Required for the degradation of mRNA in mitochondria.
O74832
P53849
GIS2_YEAST
Zinc finger protein GIS2
Saccharomyces
MSQKACYVCGKIGHLAEDCDSERLCYNCNKPGHVQTDCTMPRTVEFKQCYNCGETGHVRSECTVQRCFNCNQTGHISRECPEPKKTSRFSKVSCYKCGGPNHMAKDCMKEDGISGLKCYTCGQAGHMSRDCQNDRLCYNCNETGHISKDCPKA
May act in the sexual differentiation pathway.
P53849
P55555
Y4LO_SINFN
Serine/threonine-protein acetyltransferase NGR_a02610
Sinorhizobium
MQLSRRAEIGNPSSRNLSPRINEKVELLGQALEHARRAGMSSSLMEYGRQVARHLSANVQPDEKILSLDIRNLPLLAASYNRRYPDLDLRHMDSPARFFDALNDRSSDGAWRAVVRLADGEQHHVAADVRTRAGAAPTIIVMEGANFYTFVASYFKLRGDSFRQLGTQAKWAFIEVGAQKSAADCVMFGVQFALAAYRELPTFDAWHDNLHHHGTIAHEGDYSSDYMPRRHAGICANKPFSWGEVPPSDLLQALSLQQCN
Serine/threonine-protein acetyltransferase translocated into infected cells, which mediates acetylation of serine and threonine residues of host target proteins.
P55555
A0KRQ2
CCME_SHESA
Heme chaperone CcmE
Shewanella
MNPRRKKRLTLAVALIGGVAAIASLLLYALNSNLNLFYTPSEIVHGKTDTGVKPEAGQRIRVGGMVTVGSMVRDPNSLHVQFAVHDSLGGEILVTYDDLLPDLFREGQGIVAQGVLGEDGKLAATEVLAKHDENYMPPEVAEAMGQKHEKLDYSQQKSAAQ
Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.
A0KRQ2
Q81JA6
RNM5_BACCR
Ribosomal RNA terminal maturase M5
Bacillus cereus group
MEASMKIKEIIVVEGKDDTVAIKRAVDADTIETNGSAIGDHVIEQVKLAQQKRGVIIFTDPDYPGERIRKIISDKVPGCKHAFLPKEEALAKRKKGVGIEHASNESIRRALENIHEEMEAYTGEISWSDLVDAGLVGGEMAKSRRERMGKLLKIGYTNAKQLHKRLQMFQVSKESFAEAYKQVIQEEKK
Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step.
Q81JA6
A1B012
RL1_PARDP
50S ribosomal protein L1
Paracoccus
MAKLSKKQVSARAAFAGKSNLAVEEAVKLVKENASAKFDETVEIAMNLGVDPRHADQMVRGVVTLPNGTGKDVRVAVFARGPKADEAKAAGAEIVGAEDLMETIQSGKIEFDRCIATPDMMPLVGRLGKILGPRNLMPNPKVGTVTMDVKAAVEAAKGGEVQFKAEKAGVVHAGVGKASFEIEKLAENIRAFVDAVNRAKPSGAKGTYVKKVSISSTMGPGVSLDLGSTAAAQ
Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.
A1B012
Q64TM7
DNLJ_BACFR
Polydeoxyribonucleotide synthase [NAD(+)]
Bacteroides
MTVKEKIEQLRLQLHQHNYNYYVLNAPEISDKEFDDLMRELQDLEQEHPEYKDENSPTMRVGSDINKNFTQVAHKYPMLSLSNTYSENEVTDFYDRVRKALNEDFEICCEMKYDGTSISLTYENGKLIRAVTRGDGEKGDDVTDNVKTIRSIPLVLHGDNYPEVFEIRGEILMPWEVFEALNREKEAREEPLFANPRNAASGTLKLQNSAIVASRKLDAYLYYLLGDNLPTDGHYENLQEAAKWGFKISPLMRKCQTLQEVFDFINYWDVERKNLNVATDGIVLKVNSLKQQRNLGFTAKSPRWAIAYKFQAERALTRLNMVTYQVGRTGAVTPVANLDPVQLSGTVVKRASLHNADIIEGLDLHIGDMVYVEKGGEIIPKITGVDTSVRFMIGEKVKFITHCPECGSKLIRYEGEAAHYCPNETACPPQIKGKIEHFISRKAMNIDGLGPETVDMFYRLGLIHDTADLYRLTTDDIRGLDRMGDKSAENIIKGIMQSKEVPFERVIFALGIRFVGETVAKKIAKSFKDIEELENADLETLINIDEIGEKIARSILNYFANESNRKLVDRLKTAGLQLYRPEEDLSGHTDKLAGQSIVISGVFTHHSRDEYKDLIEKHGGKNVGSISSKTSFILAGDNMGPAKLEKASKLGIKIMNEEEFLKLIS
DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.
Q64TM7
C6HEL8
LCL2_AJECH
Long chronological lifespan protein 2
Histoplasma
MVHIFTGILLGLLLLATGTQAQFQFFEQMFGGGQQQQHDSREQNVPSDSDWYQRTYDNARCSNYLCPGTLACVAVPHHCPCQHPAVEDKFELGDGSAICVSKGGFKFGEAARKVELARKGLL
Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.
C6HEL8
Q722T9
AZOR1_LISMF
FMN-dependent NADH-azoreductase 1
Listeria
MTNVLFIKANGLPAERSVSVALYEIFLTEYKKSHPDDNVTELDLFEADLPYYDVTMMSGLHKEAAGETLSPEEKRLADIANSYLDQFLAADKIVMAFPLWNFSIPAQFLTYLFYLNQAGKTFKYTANGPVGLVADKKIALLNARGGIYSDGPMQSFEMSLSYVKNVLAHFGISEPEMVIVEGHNAKPDQAKDIISAGAKEAVELAKIF
Also exhibits azoreductase activity. Catalyzes the reductive cleavage of the azo bond in aromatic azo compounds to the corresponding amines.
Q722T9
Q95730
CYB_ARTGW
Ubiquinol-cytochrome-c reductase complex cytochrome b subunit
Artibeus
MTNIRKTHPLLKIINSSFVDLPAPSSLSSWWNFGSLLGVCLGVQILTGLFLAMHYTSDTATAFNSVNHICRDVNYGWLLRYLHANGASMFFICLYLHVGRGLYYGSYTYSETWNIGILLLFAVMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGFSVDKATLTRFFAFHFLLPFIVTALVMVHLLFLHETGSNNPTGIPSDPDMIPFHPYYTIKDILGFLVMLTALATLVLFSPDLLGDPDNYIPANPLTTPPHIKPEWYFFFAYAILRSIPNKLGGVLALVVSILILAIVPILHMSKQRSMMFRPLSQCLFWLLVAVLFTLTWIGGQPVEHPYIIIGQTASALYFLIILFLMPMTSMVENYLLKW
Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.
Q95730
Q9HDB9
GAK5_HUMAN
HERV-K_3q12.3 provirus ancestral Gag polyprotein
Homo
MGQTKSKTKSKYASYLSFIKILLKRGGVRVSTKNLIKLFQIIEQFCPWFPEQGTLDLKDWKRIGEELKQAGRKGNIIPLTVWNDWAIIKAALEPFQTKEDSVSVSDAPGSCVIDCNEKTGRKSQKETESLHCEYVTEPVMAQSTQNVDYNQLQGVIYPETLKLEGKGPELVGPSESKPRGPSPLPAGQVPVTLQPQTQVKENKTQPPVAYQYWPPAELQYLPPPESQYGYPGMPPALQGRAPYPQPPTVRLNPTASRSGQGGTLHAVIDEARKQGDLEAWRFLVILQLVQAGEETQVGAPARAETRCEPFTMKMLKDIKEGVKQYGSNSPYIRTLLDSIAHGNRLTPYDWESLAKSSLSSSQYLQFKTWWIDGVQEQVRKNQATKPTVNIDADQLLGTGPNWSTINQQSVMQNEAIEQVRAICLRAWGKIQDPGTAFPINSIRQGSKEPYPDFVARLQDAAQKSITDDNARKVIVELMAYENANPECQSAIKPLKGKVPAGVDVITEYVKACDGIGGAMHKAMLMAQAMRGLTLGGQVRTFGKKCYNCGQIGHLKRSCPVLNKQNIINQAITAKNKKPSGLCPKCGKGKHWANQCHSKFDKDGQPLSGNRKRGQPQAPQQTGAFPVQLFVPQGFQGQQPLQKIPPLQGVSQLQQSNSCPAPQQAAPQ
The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution.
Q9HDB9
P37528
PDXT_BACSU
Pyridoxal 5'-phosphate synthase glutaminase subunit
Bacillus
MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLILPGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNVVVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAKQGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV
Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
P37528
Q8R4P9
MRP7_MOUSE
Multidrug resistance-associated protein 7
Mus
MEGLLAQLCGTDAARPLPLWEGDTTGHCFTQLVLSALPHALLAVLSACHLGTPRTTNHSPALNPGWRLRLAASFLLSIFPLLDLLPVVLPPGSRPGPLWLEVLAGCVTAVAWFTHSLALWALVHSPHGRSRGPLALALAAFLPTPALVLTLLWHCQRGTFLPPLLPGPLGRVCLLILQLAAVLAYGLGWAAPGGPQEPWTHDPFLSSESQETEVAEDGESWLSRFSYAWLAPLLARGVRGELQQPRDTCRLPRRLHPAFLARVFQAHWKEGAQLWRALYRAFGCCYLALGLLKMVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYVLGLAGGTVISAVLQNQYGYEVRKVTLQARVAVLSTLYRKALKLGPSRPPTGEVLNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGMAFLAGLVLALLLVPVNKVIATRIMASNQEMLRHKDARVKLMTELLSGIRVIKFFRWEQALGDRVKACRTKELGRLRVIKYLDAACVYLWAALPVVICITIFITYVLMGHQLTATKVFTALALVRMLILPLNNFPWVINGLLESKVSLDRIQRFLDLPSYSPEAYYSPDPPAEPSTALELHEALFSWDPIGASQKTFISHLQVKKGMLVGIVGKVGCGKSSLLAAITGELHRLCGWVAVSELSKGFGLATQEPWIQCATIRDNILFGKTFDAQLYREVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDADVANHLLHRCILGVLSHTTRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEILPLVQAVPTAWAEKEQVATSGQSPSVCDLERTTEEELEVEQSTCGCLVQEESKSEGAVALHVYRAYWRAMGSGLAAAILVSLLLMQATRNGADWWLAHWLSQLKAGRNGSREDPASCSPGSTALFSPRLLLFSPGNLYTPLLSTPLHKAASNGTADVHFYLIVYATIAGVNSLCTLLRAVLFAAGALQAAASLHHRLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFLLNILLANSVGLLGLLAVLGSGLPWLLLLLPPLSFVYYSVQGYYRASFRELRRLGSLTWSPLYSHLADTLAGLPVLRAAGATYRFEEENQRLLELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLVLSYALSLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDVPQEPHSQPLQSPHQQRISWLTQGSVEFQDVVLVYRPGLPNALDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLDNVDTSQLELAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVAVAMGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQPHSLFQQLLQSSQQGAHSGPSGC
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP.
Q8R4P9
A1B673
ILVD_PARDP
Dihydroxy-acid dehydratase
Paracoccus
MPAYRSRTTTHGRNMAGARGLWRATGVKNSDFGKPIIAIVNSFTQFVPGHVHLKDLGQMVAREVEAAGGIAKEFNTIAVDDGIAMGHDGMLYSLPSRELIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAIFVSGGPMEAGKVTLGDGRKVSLDLVDAMVAAADDKISDADLAAIEEAACPTCGSCSGMFTANSMNCLSEALGLSLPGNGSTLATHAFRKNLFLEAGRRIVEVTRRHYEQDDASVLPRAIASKAAFLNAMSLDIAMGGSTNTVLHLLAIAQEGGVDFTMDDIDALSRKVPCLCKVAPNTANVHMEDVHRAGGIMAILGELDRAGLIDRDCPTVHAPTIGAAIDQWDIARSNDPQARELFLAAPGGVPTQVAFSQATLWPDLDLDREHGVIRSAKAPFSKDGGLAVLKGNVALDGCIVKTAGVDESILVFSGRAKVYESQDAAVSGILTGKVEAGDVVVIRYEGPKGGPGMQEMLYPTSYLKSKGLGKACALITDGRFSGGTSGLSIGHVSPEAAAGGTIGLVRDGDRIEIDIPNRSIRLAVPEDELAARRAEQDAKGWKPAQPRQRQVSAALKVYAQFAASADKGAVRILPE
Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.
A1B673
P80972
COX5A_THUOB
Cytochrome c oxidase polypeptide Va-1
Thunnus
SHGKVETDEEFDARWVTYFS
Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
P80972
Q9UU82
AREH2_SCHPO
Sterol-ester synthase 2
Schizosaccharomyces
MIAATPAKSKPSDVNLEQTFKGVSETSKIDLRRSRAAYRPLELSPTPSIFARNYQRNAVDFTGFFVLFWVAVSIMIFMSFLENFELTGRPVVGTIFKYFQSNLLDLAKADLAMSSMFLLAFPFQKIFALGYLRWYGLGVYLYSILILLFLSHCVLRCCLSNWSWTHRAMFILHSMVILMKLHSYNVVNGWYSYCYHSLNKLQSKKTDLDDDERSSVEFYEHCLNHHGNTYPENLTIPNALDFLFMPSLCYQLYYPRTAHVRIHYLIECALGTFGCIFLLVIISDHFMVPVLAKAIRTIIEAPEDASATYFAIRLGHTVAFLMFPFMLSFLLVFWVIFEGVCNFSAEITRFADRNFYDDWWNCWTWDQFARTWNKPVHYFLLRHVYVPLNSFMSKSLSTFFTFFVSSVLHELVMGCITLKIRGYGLFFQMTQIPYIIIQRQKFVRRHRLLGNIAFWFSIIIGIALIAALYILF
Sterol O-acyltransferase that catalyzes the formation of stery esters.
Q9UU82