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<|newrecord|> nctId: NCT06318312 id: HYP_MR_2024 briefTitle: Effects of Hypoxia on Cognitive Performance acronym: HYPCOG overallStatus: NOT_YET_RECRUITING date: 2024-03-27 date: 2024-04-12 date: 2024-05-03 date: 2024-03-19 date: 2024-03-19 name: University of Castilla-La Mancha class: OTHER briefSummary: The goal of th... |
* What is the best hypoxia exposure to improve reaction time, anticipation, attention and memory tasks? |
* Which hypoxia exposure causes the greatest detriments in cognitive function? conditions: Hypoxia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER primaryPurpose: BASIC_SCIENCE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 30 ... |
<|newrecord|> nctId: NCT06318299 id: 109227 briefTitle: Effects of Exogenous Ketone Ester Supplementation on 3-hydroxybutyrate Concentrations in Human Cerebrospinal Fluid acronym: KetoBrain overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-12 date: 2024-12 date: 2024-03-19 date: 2024-03-21 name: University of ... |
Ketone bodies can be administered exogenously, and the most commonly used in clinical trials is 3-hydroxybutyrate (3-OHB). 3-OHB is carried by simple diffusion and facilitated diffusion through several monocarboxylic acid transporters (MCTs) across the blood-brain barrier. |
To our knowledge, no studies in human adults exist that concurrently measure 3-OHB concentrations in blood and cerebrospinal fluid (CSF) after ingestion or infusion of exogenous ketone supplementation, necessitating further study. |
Aims: |
* The 3-OHB CSF/blood ratio after oral ingestion of 30 g ketone ester - primary endpoint |
* The window of effect: Ketone supplementation 1 h or 2 h before CSF sampling |
* If concentration measurements by point-of-care testing are non-inferior to mass spectrometry |
* If acute 3-OHB ingestion increases plasma brain-derived neurotrophic factor (BDNF) levels conditions: Ketosis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 24 type: ESTIMATED name: Ketone Ester name: ... |
<|newrecord|> nctId: NCT06318286 id: MK3475-IIT-60977 briefTitle: Study of Pembrolizumab Plus Chemotherapy With Lenvatinib for Malignant Pleural Mesothelioma acronym: PENINSULA overallStatus: NOT_YET_RECRUITING date: 2024-03-13 date: 2026-04-30 date: 2026-10-30 date: 2024-03-19 date: 2024-03-19 name: Hyogo Medical Univ... |
<|newrecord|> nctId: NCT06318273 id: M24-742 briefTitle: A Study to Assess Adverse Events, and How Intravenously (IV) Infused ABBV-969 Moves Through the Bodies of Adult Participants With Metastatic Castration-Resistant Prostate Cancer overallStatus: RECRUITING date: 2024-03-08 date: 2027-06-16 date: 2027-06-17 date: 20... |
ABBV-969 is an investigational drug being developed for the treatment of metastatic castration-resistant prostate cancer (mCRPC). There are parts to this study. Participants will receive ABBV-969 as a single agent at different doses. Approximately 120 adult participants will be enrolled in the study across sites worldw... |
In part 1 (dose escalation), ABBV-969 will be intravenously infused in escalating doses as a monotherapy. In part 2, multiple doses will be selected from Part 1 and mCRPC participants will be assigned to one of these doses in a randomized fashion to determine the recommended Phase 2 dose. The estimated duration of the ... |
There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, and scans. conditions: Metastatic Castration-Resistant Prostate Cancer study... |
<|newrecord|> nctId: NCT06318260 id: 2023-508298-10-00 briefTitle: Haemodynamic Effects of Dobutamine in Patients With Wild-type Transthyretin Amyloid Cardiomyopathy (ATTRwt) acronym: DobATTR overallStatus: RECRUITING date: 2024-04-08 date: 2025-09 date: 2026-03 date: 2024-03-19 date: 2024-04-17 name: Steen Hvitfeldt P... |
* What are the effects of increasing dosages of dobutamine infusion on cardiac output and filling pressures in patients with symptomatic ATTRwt. |
* Safety of dobutamine infusion in this patient population. |
Participants will be given increasing dosages of dobutamine infusion, and its effect on cardiac output and filling pressures will be assessed non-invasively by echocardiography, and invasively by right heart catheterization, simultaneously. conditions: ATTR Amyloidosis Wild Type studyType: INTERVENTIONAL phases: PHASE1... |
<|newrecord|> nctId: NCT06318247 id: 2022-134(R) briefTitle: Using Xenograft Combined With Barrier Membrane to Improve the Formation of Deep Periodontal Pockets overallStatus: RECRUITING date: 2023-06-01 date: 2024-12-30 date: 2025-12-30 date: 2024-03-19 date: 2024-03-19 name: The Dental Hospital of Zhejiang University... |
<|newrecord|> nctId: NCT06318234 id: 202435 briefTitle: PET/MR Evaluation of Regression Grading After Neoadjuvant Therapy for Rectal Cancer overallStatus: RECRUITING date: 2024-01-01 date: 2025-12-31 date: 2025-12-31 date: 2024-03-19 date: 2024-03-19 name: Xiao Chen class: OTHER briefSummary: This project aims to evalu... |
<|newrecord|> nctId: NCT06318221 id: 06156930 briefTitle: Effects of Perioperative Immunonutrition in Patients With Head and Neck Cancer overallStatus: COMPLETED date: 2019-05-01 date: 2021-02-01 date: 2021-02-01 date: 2024-03-19 date: 2024-03-19 name: TC Erciyes University class: OTHER briefSummary: A prospective rand... |
Five days before surgery and the postoperative day 10, immunonutrition support was given to the intervention group (n=17), and standard EN support was given to the control group (n=17). Body analyses were made, food consumption records were taken, NRS-2002 and quality of life scales were applied, and biochemical parame... |
<|newrecord|> nctId: NCT06318208 id: C-LCI briefTitle: Pulmonary Function in Non-hospitalized Adults and Children After Mild COVID-19 overallStatus: COMPLETED date: 2021-04-20 date: 2022-01-03 date: 2022-01-03 date: 2024-03-19 date: 2024-03-26 name: University of Rostock class: OTHER briefSummary: The study investigate... |
Therefore, 110 patients, aged 6-60 years, were recruited by telephone 4-12 weeks after laboratory-confirmed positive PCR and invited for a lung function testing. Every patient with abnormalities in pulmonary function was invited to a follow-up 3 months after the first appointment to assess changes in lung function valu... |
Patients with a pre-existing lung disease and smokers within the last five years were excluded beforehand. |
Additionally to lung function testing we did a throat swab at each appointment to analyse via Multiplex PCR whether the patients had any other respiratory infection at the time of the pulmonary function testing. conditions: SARS-CoV-2 Infection studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPE... |
<|newrecord|> nctId: NCT06318195 id: 2023-06821-01 briefTitle: Condensed Digital Prolonged Exposure for Individuals Treated Within Somatic Trauma Care. acronym: CiPE overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-02 date: 2026-08 date: 2024-03-19 date: 2024-03-19 name: Karolinska Institutet class: OTHER nam... |
<|newrecord|> nctId: NCT06318182 id: NCT-SBF-EK-001 briefTitle: Testicular Self-Examination Awareness in Young Men overallStatus: ACTIVE_NOT_RECRUITING date: 2022-12-09 date: 2023-11-20 date: 2024-07-15 date: 2024-03-19 date: 2024-03-19 name: Hitit University class: OTHER name: Ondokuz Mayıs University briefSummary: Th... |
H0 Hypothesis: Education based on the health belief model has no effect on the awareness of testicular self-examination and health beliefs about testicular self-examination of young men in the experimental and control groups. |
H1a Hypothesis: The training based on the health belief model will increase the awareness of young men in the experimental group about testicular self-examination compared to those in the control group. |
H1b Hypothesis: The training based on the health belief model will increase the mean scores of the sensitivity subscale of young men in the experimental group compared to those in the control group. |
H1c Hypothesis: The training based on the health belief model will increase the mean scores of the benefit subscale of young men in the experimental group compared to those in the control group. |
H1d Hypothesis: The training based on the health belief model will increase the mean scores of the seriousness subscale of young men in the experimental group compared to those in the control group. |
H1e Hypothesis: The training based on the health belief model will decrease the mean scores of the barriers subscale of young men in the experimental group compared to those in the control group. |
H1f Hypothesis: The training based on the health belief model will increase the mean scores of the health motivation subscale of young men in the experimental group compared to those in the control group. |
H1g Hypothesis: The training based on the health belief model will increase the mean scores of the self-efficacy subscale of young men in the experimental group compared to those in the control group. conditions: Testicular Cancer studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL p... |
<|newrecord|> nctId: NCT06318169 id: BIO89-100-131 briefTitle: A Study Evaluating the Efficacy and Safety of Pegozafermin in Participants With MASH and Fibrosis (ENLIGHTEN-Fibrosis) overallStatus: RECRUITING date: 2024-03-13 date: 2026-12 date: 2029-02 date: 2024-03-19 date: 2024-04-29 name: 89bio, Inc. class: INDUSTRY... |
<|newrecord|> nctId: NCT06318156 id: ZSLL-KY-2024-056-03 briefTitle: Exploring the Distribution Patterns and Infrared Characteristics of Force-sensitive Acupoints in Different Lumbar Nerve Segments in Patients With LDH Based on "Press Quickly" Theory overallStatus: RECRUITING date: 2022-01-01 date: 2025-01-01 date: 202... |
<|newrecord|> nctId: NCT06318143 id: U01HL168084 type: NIH link: https://reporter.nih.gov/quickSearch/U01HL168084 briefTitle: mAnaging siCkle CELl disEase Through incReased AdopTion of hydroxyurEa in Nigeria acronym: ACCELERATE overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2027-08 date: 2028-03 date: 2024-03-19... |
<|newrecord|> nctId: NCT06318130 id: LEAD-LBP briefTitle: Comparison of Pacing Lead Design on Left Bundle Branch Pacing Outcomes acronym: LEAD-LBP overallStatus: RECRUITING date: 2023-01-01 date: 2024-12-31 date: 2025-06-30 date: 2024-03-19 date: 2024-04-05 name: National University Hospital, Singapore class: OTHER bri... |
Group 1: Fixed helix, lumenless pacing lead (FHL) Group 2: Extendable helix, stylet driven pacing lead (EHL) primaryPurpose: TREATMENT masking: TRIPLE maskingDescription: Subjects will be blinded to the type of pacing lead received. Operators will not be blinded as they will be performing the procedure. Post-procedure,... |
<|newrecord|> nctId: NCT06318117 id: 3398-1 briefTitle: Reason for Prescribing Rice Infant Formula overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2025-09-30 date: 2025-12-31 date: 2024-03-19 date: 2024-03-25 name: Mead Johnson Nutrition class: INDUSTRY name: BioFortis briefSummary: The main purpose of this st... |
<|newrecord|> nctId: NCT06318104 id: DI/24/310/03/4 briefTitle: Efficacy and Safety of a Triple Eradication Scheme for Helicobacter Pylori Based on Tegoprazan vs Esomeprazole overallStatus: NOT_YET_RECRUITING date: 2024-04-19 date: 2024-11-29 date: 2025-02-28 date: 2024-03-19 date: 2024-03-19 name: Hospital General de ... |
<|newrecord|> nctId: NCT06318091 id: MS.21.09.1640 briefTitle: Nanofat Versus Platelet Poor Plasma Gel for Infraorbital Rejuvenation overallStatus: COMPLETED date: 2021-06-01 date: 2023-06-01 date: 2023-06-01 date: 2024-03-19 date: 2024-03-19 name: Mansoura University class: OTHER briefSummary: this study was conducted... |
<|newrecord|> nctId: NCT06318078 id: UG2024001 briefTitle: Buikwe Electronic Community Health Information System Impact Study overallStatus: RECRUITING date: 2023-12-01 date: 2024-04 date: 2024-07 date: 2024-03-19 date: 2024-03-19 name: Malaria Consortium class: OTHER briefSummary: The purpose of the study is to invest... |
<|newrecord|> nctId: NCT06318065 id: B-ER111-370 briefTitle: Surgical Resection Outcomes in Patients With Brain Metastasis overallStatus: RECRUITING date: 2010-01-01 date: 2024-06-01 date: 2024-09-01 date: 2024-03-19 date: 2024-03-22 name: National Cheng-Kung University Hospital class: OTHER briefSummary: While many st... |
<|newrecord|> nctId: NCT06318052 id: LUM-ABU-CO2-FemTouch-19-01 briefTitle: The Effect Of Fractional CO2 Laser Therapy On Cancer Survivors With Genitourinary Syndrome Of Menopause (GSM) overallStatus: RECRUITING date: 2019-11-01 date: 2024-11 date: 2024-11 date: 2024-03-19 date: 2024-03-20 name: Lumenis Be Ltd. class: ... |
<|newrecord|> nctId: NCT06318039 id: IRB2022-06554-01 briefTitle: Operation ACL: Rehabilitation After Anterior Cruciate Ligament Reconstruction overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2027-03-01 date: 2027-10-01 date: 2024-03-19 date: 2024-04-08 name: Linnaeus University class: OTHER briefSummary: Scie... |
Overall Purpose: |
Regarding rehabilitation after anterior cruciate ligament reconstruction (ACLR), there is a knowledge gap - a lack of evidence. Important questions such as how rehabilitation should be structured, what it should include, and how it should be evaluated are currently not clear. Therefore, the investigators plan to conduc... |
Moreover, detailed information on how/under what circumstances the ACL injury occurred is not satisfactorily described in the literature. Therefore, the investigators are planning a new survey that can identify, explain, and prevent the risk factors causing a person to suffer from an anterior cruciate ligament injury. |
Specific Objectives: |
How should guidelines for rehabilitation after ACLR be structured, what should they include, and how should they be evaluated to best restore knee function in the patient? Can a detailed and comprehensive survey identify, explain, and prevent the risk factors causing a person to suffer from an ACL injury? conditions: A... |
<|newrecord|> nctId: NCT06318026 id: R01AA031231 type: NIH link: https://reporter.nih.gov/quickSearch/R01AA031231 id: R01AA031231 type: NIH link: https://reporter.nih.gov/quickSearch/R01AA031231 briefTitle: Systematic Implementation of Patient-centered Care for Alcohol Use Trial: Beyond Referral to Treatment overallSta... |
<|newrecord|> nctId: NCT06318013 id: 2022-KAEK-15427-04-204-2022101 briefTitle: Perineural and Systemic Dexamethasone Use in Dental Surgeries in Terms of Anesthesia Duration and Postop Complaints overallStatus: RECRUITING date: 2024-03-27 date: 2024-04-15 date: 2024-07-01 date: 2024-03-19 date: 2024-03-29 name: Karaman... |
<|newrecord|> nctId: NCT06318000 id: SN4/20/22 briefTitle: Physical Activity and Sports for People With Visual Impairments overallStatus: COMPLETED date: 2020-03-01 date: 2022-12-31 date: 2022-12-31 date: 2024-03-19 date: 2024-03-20 name: Józef Piłsudski University of Physical Education class: OTHER briefSummary: Purpo... |
<|newrecord|> nctId: NCT06317987 id: 2068557 id: P50DA054072 type: NIH link: https://reporter.nih.gov/quickSearch/P50DA054072 briefTitle: Addressing Barriers to Care for Substance Use Disorder Pilot Study acronym: ABCSUD Pilot overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-02 date: 2025-04-02 date: 20... |
This study will be conducted in a mental health treatment access center within the Washington region of Kaiser Permanente. As part of usual care, patients contact the mental health access center and speak to a "care coordinator" to obtain contact information for potential venues to obtain treatment for substance use di... |
The experimental intervention, Care Navigation, will be evaluated for its potential to increase the utilization of substance use disorder treatment among patients who contact the mental health treatment access center. The investigators note that Care Navigation will be delivered by study "care navigators", who are dist... |
<|newrecord|> nctId: NCT06317974 id: 2022/210 briefTitle: The Effect of Breastfeeding Education on Breast Milk Perception and Self-Efficacy in the Pregnancy Health Belief Model overallStatus: COMPLETED date: 2022-06-30 date: 2022-12-31 date: 2023-02-15 date: 2024-03-19 date: 2024-03-19 name: Istanbul University - Cerra... |
<|newrecord|> nctId: NCT06317961 id: INT200-22 briefTitle: Pilot Study on the Use of iENTER, iCONSENT and iPARTICIPATE E-tools overallStatus: RECRUITING date: 2023-04-05 date: 2025-01-31 date: 2025-01-31 date: 2024-03-19 date: 2024-03-19 name: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano class: OTHER name: Va... |
<|newrecord|> nctId: NCT06317948 id: IG23150 briefTitle: Improving the Quality of Radiotherapy by Multi-Institution Knowledge-Based Planning Optimization Models (Acronym: MIKAPOCo, Multi-Institutional Knowledge-based Approach in Plan Optimization for the Community) acronym: MIKAPOCo overallStatus: ENROLLING_BY_INVITATI... |
Quantifying Inter-institute variability of RT planning and building libraries of interchangeable and validated multi-Institutional KB plan prediction models is expected to impact on the quality of planning at the national level. The project has the potential of facilitating the introduction of AI approaches in plan opt... |
<|newrecord|> nctId: NCT06317935 id: HU-ERG-BK-01 briefTitle: The Effect of Virtual Reality Application on Independence and Hand Functions in Daily Life in Children With CP overallStatus: NOT_YET_RECRUITING date: 2024-04-23 date: 2024-06-29 date: 2024-10-29 date: 2024-03-19 date: 2024-03-19 name: Hacettepe University c... |
The research is a randomized controlled, cross-over study. The sample group of the research is children diagnosed with hemiplegic cerebral palsy and families who are receiving inpatient treatment in the pediatric service of Ankara City Hospital Physical Therapy and Rehabilitation Hospital. |
Two groups, intervention (A) and control (B), will be created from the target research group using the randomization method. |
The upper extremity functionality of both research groups before the intervention will be evaluated with the 'Motor Activity Diary for Children' scale and the perceived independence level with the 'Children's Hand Use Experience' scale. |
After the initial evaluation is completed, group A, represented as the intervention group, will receive ArmeoSenso virtual reality intervention in the upper extremity hand function laboratory for 3 weeks, 5 days a week, each session for 30 minutes, in addition to traditional occupational therapy and physiotherapy rehab... |
Measurement tools will be repeated at the beginning of the intervention, at the end of the 3rd week, and at the end of the intervention. conditions: Hemiplegic Cerebral Palsy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Two groups, intervention (... |
Intervention group (A) will receive virtual reality application for 30 minutes, 5 days a week for 3 weeks, in addition to traditional occupational therapy and physiotherapy approaches for the first 3 weeks, and will receive only traditional treatments between 3-6 weeks. |
The control group (B) will receive only traditional occupational therapy and physiotherapy approaches for the first 3 weeks, and between 3-6 weeks, they will receive virtual reality application in addition to traditional approaches for 30 minutes, 5 days a week for 3 weeks. primaryPurpose: SUPPORTIVE_CARE masking: DOUB... |
<|newrecord|> nctId: NCT06317922 id: DRYEYE-IVT Project briefTitle: Evaluation of Dry Eye Disease's Signs in Patients Who Were Administered Intravitreal Anti-VEGF Injections acronym: DRYEYE-IVT overallStatus: RECRUITING date: 2024-02-05 date: 2025-05-12 date: 2025-05-12 date: 2024-03-19 date: 2024-03-20 name: Francesco... |
The main questions it aims to answer are: |
* can ocular instillation of Thealoz Duo solution, 1 week before intravitreal injection, in a fixed dose regimen, prevent ocular surface changes and dry-eye signs? |
* can ocular instillation of Thealoz Duo solution, up 3 months after intravitreal injections, in a fixed dose regimen, reduce ocular surface changes, and dry-eye signs with improvement of quality of life and quality of vision? |
Each participant will be randomized into each of two arms: |
1. TREATMENT ARM: patients who will receive the instillation of Thealoz Duo, 10 ml, 1 drop, 4 times/day; |
2. CONTROL ARM: patients who will receive the instillation of saline solution (Hydrabak), 10 ml, 1 drop, 4 times /day; |
The decision of inclusion of a control group should minimize the risk of breaking the blinding condition by affecting the consistency and reliability of the outcome's achievement. |
In any case, the instillation of saline solution should not alter the ocular surface. conditions: Dry Eye Syndromes studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The participants will be randomized in two arms (treatment arm and control arm) in a r... |
1. MASKED TEAM: Sub-investigators and study coordinators delegated to perform the following tasks: |
* dispensation to the patient the Investigational medical device (Thealoz Duo) or saline solution (Hydrabak containing Sodium Chloride 0,9 g, Sodium Dihydrogen Phosphate Dihydrate, Disodium Hydrogen Phosphate Dodecahydrate); |
* accountability of Investigational medical device and saline solution; |
* verify the compliance and therapeutic adherence of the patient; |
* discussion with the patient regarding the respect of the masked condition of the study; |
2. UNMASKED TEAMS: |
* informed consent process; |
* to perform the follow-up visit and assessments provided to test the ocular surface. whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Thealoz Duo; name: sham (Hydrabak) measure: Administration of Ocular Surface Disease Index (OSDI) to the patient measure: ad... |
<|newrecord|> nctId: NCT06317909 id: 23-03 DONNER-2 briefTitle: Development of a Novel Non-invasive Inflammometry Following Allergen Challenge in Patients With Mild Allergic Asthma overallStatus: RECRUITING date: 2024-06-01 date: 2025-09 date: 2025-09 date: 2024-03-19 date: 2024-03-19 name: Fraunhofer-Institute of Toxi... |
The investigator wants to further profile and develop the allergen challenge model by investigating the utility of various non-invasive monitoring methods. The hypothesis of the project is that local inflammatory changes in the lung induced by allergen can be captured by gas-enhanced magnetic resonance imaging (MRI) an... |
The validation of cellular outcome measures and non-invasive inflammometry can be used in future clinical trials for proof of concept of novel anti-inflammatory medications. |
Participants will undergo |
* methacholine challenge |
* 2 inhaled allergen challenges |
* 2 MRI with hyperpolarized xenon and gadolinium based contrast agent |
* 2 bronchoscopies with bronchoalveolar lavage (BAL) |
* segmental allergen challenge during the first bronchoscopy |
* spirometry |
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