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* To investigate the incidence and prevalence of FACEs with respect to Fabry specific treatment, Migalastat, ERT or no treatment.
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* To describe FACEs in accordance with different geno- and phenotypic groups.
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* To investigate the incidence and time to a first fatal or non-fatal cardiac, renal, and cerebrovascular clinical event, separated by each category.
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Primary outcomes - Time to first FACE (cardiac, renal, and cerebrovascular) with particular focus on Migalastat on clinical outcomes and treatment outcomes preceding Migalastat therapy.
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Secondary outcomes
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* To investigate the incidence and prevalence of FACEs with respect to Fabry specific treatment, Migalastat, ERT or no treatment.
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* To describe FACEs in accordance with different geno- and phenotypic groups To investigate the incidence and time to a first fatal or non-fatal cardiac, renal and cerebrovascular clinical event, separated by each category.
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Exploratory outcomes
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- To describe disease progression with focus on organ involvement.
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The study design is a retrospective clinical and paraclinical follow-up of the Danish National Fabry cohort in the period 01.01.2001-31.12.2022. Patient followed a structured yearly monitoring program as part of routine clincal care. conditions: Fabry Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 115 type: ESTIMATED measure: Time to first individual FACE since confirmed diagnosis (Composite endpoint) measure: Time to first FACE after initiation of Migalastat treatment (Composite endpoint) measure: Time to first individual FACE since confirmed diagnosis (cardiac) measure: Time to first individual FACE after initiation of Migalastat treatment (cardiac) measure: Time to first individual FACE since confirmed diagnosis (renal) measure: Time to first individual FACE after initiation of Migalastat treatment (renal) measure: Time to first individual FACE after initiation of Migalastat treatment (cerebrovascular) measure: Time to first individual FACE since confirmed diagnosis (cerebrovascular) measure: Prevalence of FACE since confirmed diagnosis measure: Prevalence of FACE after initiation of Fabry-specific treatment measure: Incidence of FACE since confirmed diagnosis measure: Incidence of FACE after initiation of Fabry-specific treatment measure: Incidence of cardiac events since confirmed diagnosis measure: Incidence of renal events since confirmed diagnosis measure: Incidence of cerebrovascular events since confirmed diagnosis measure: Incidence of cardiac events after initiation of Fabry-specific treatment measure: Incidence of renal events after initiation of Fabry-specific treatment measure: Incidence of cerebrovascular events after initiation of Fabry-specific treatment measure: Annualized rate of change in eGFR by CKDEPI-formula since initiation of treatment measure: Annualized rate of change in eGFR by CKDEPI-formula after initiation of Fabry-specific treatment measure: Rapid renal progression of disease since confirmed diagnosis measure: Rapid renal progression of disease after initiation of Fabry-specific treatment measure: Incidence of albuminuria since confirmed diagnosis measure: Incidence of albuminuria after initiation of Fabry-specific treatment measure: Prevalence of albuminuria since confirmed diagnosis measure: Prevalence of albuminuria after initiation of Fabry-specific treatment measure: Organ-specific decline sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Rigshospitalet city: Copenhagen zip: 2100 country: Denmark lat: 55.67594 lon: 12.56553 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2023-06-30 uploadDate: 2024-02-21T07:57 filename: Prot_000.pdf size: 1310571 typeAbbrev: SAP hasProtocol: False hasSap: True hasIcf: False label: Statistical Analysis Plan date: 2023-12-13 uploadDate: 2024-01-12T12:10 filename: SAP_001.pdf size: 519985 hasResults: False
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<|newrecord|> nctId: NCT06303453 id: REC/RCR&AHS/23/0291 briefTitle: Comparative Effects of Balance and Resisted Training in Diabetic Peripheral Neuropathy. overallStatus: RECRUITING date: 2024-02-25 date: 2024-05-01 date: 2024-05-15 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: The aim of this study is to determine comparative effects of balance and resisted training on pain and balance in patients with daibetic peripheral neuropathy. conditions: Diabetic Peripheral Neuropathy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The study would be single blinded as assessor of the study would be kept blind of the treatment groups to which patient will be allocated. whoMasked: OUTCOMES_ASSESSOR count: 58 type: ESTIMATED name: Balance exercises name: Resisted exercises measure: Michigan neuropathy screening instrument measure: De Morton mobility index test measure: PainDETECT Tool sex: ALL minimumAge: 40 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Riphah International University status: RECRUITING city: Lahore state: Punjab zip: 54660 country: Pakistan name: Muhammad Kashif, PhD-PT role: CONTACT phone: 03333125303 email: Kashif.shaffi@gmail.com name: Muhammad Kashif, PhD-PT role: CONTACT phone: 03333125303 email: Kashif.shafi@gmail.com lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06303440 id: REC/RCR&AHS/23/0288 briefTitle: Effects of Virtual Reality Training Versus Motor Imagery in Children With Cerebral Palsy overallStatus: RECRUITING date: 2024-02-25 date: 2024-05-10 date: 2024-05-25 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: Cerebral palsy is a neurodevelopmental disorder caused by brain injury that appears in infancy, children have mostly issues of gross motor functions, and activities of daily living. Virtual Reality is an innovative technique for the improvement of balance and motor function in most of the neurological conditions. Motor Imagery is an ability to engage in the mental representation of a task consciously without generating a voluntary movement. The aim of this study is to determine the comparative effects of Virtual Reality and Motor Imagery on balance, gross motor function and activities of daily living in children with cerebral palsy. conditions: Cerebral Palsy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The study would be single blinded as assessor of the study would be kept blind of the treatment groups to which patient will be allocated whoMasked: OUTCOMES_ASSESSOR count: 75 type: ESTIMATED name: Routine Physical Therapy+ Balance Training name: Virtual Reality+ Routine Physical Therapy name: Motor Imagery+ Routine Physical Therapy measure: Gross Motor Function Classification System(GMFCS) measure: Bruininks-Oseretsky Test of motor function Proficiency-2 (BOT-2 ) measure: WeeFIM scale sex: ALL minimumAge: 7 Years maximumAge: 12 Years stdAges: CHILD facility: Riphah International University status: RECRUITING city: Lahore state: Punjab zip: 54660 country: Pakistan name: Muhammad Kashif, PhD-PT role: CONTACT phone: 03333125303 email: Kashif.shaffi@gmail.com lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06303427 id: REC/RCR & AHS/23/0292 briefTitle: Effects of Modified Constraint-induced Movement Therapy With and Without Electrical Stimulation in Erb's Palsy overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-05-01 date: 2024-05-15 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: ERB's palsy is an injury of upper section of the brachial plexus (C5-6) leading to an internally rotated and adducted shoulder and a pronated forearm. Modified constraint-induced movement therapy improves the functionality of the affected limb, while electrical stimulation helps in the improvement of active range of motion and muscle strength in ERB's palsy patients. This study aims to investigate the effects of modified constraint-induced movement therapy with and without electrical stimulation on range of motion, muscle strength, and motor functions in patients with ERB's Palsy. conditions: Erb's Palsy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The study would be single-blinded as the assessor of the study would be kept blind to the treatment groups to which patients will be allocated. whoMasked: OUTCOMES_ASSESSOR count: 34 type: ESTIMATED name: Modified constraint-induced movement therapy name: Electrical stimulation measure: Standard universal goniometer measure: Medical Research Council (MRC) Scale measure: Active Movement Scale sex: ALL minimumAge: 2 Years maximumAge: 6 Years stdAges: CHILD facility: Riphah International University city: Lahore state: Punjab zip: 54660 country: Pakistan name: Muhammad Kashif, PhD-PT role: CONTACT phone: 03333125303 email: kashif.shaffi@gmail.com lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06303414 id: RESCO briefTitle: Revascularization for Symptomatic Non-acute Carotid Artery Occlusion acronym: RESCO overallStatus: RECRUITING date: 2016-06-17 date: 2028-12-30 date: 2028-12-30 date: 2024-03-12 date: 2024-03-12 name: Xuanwu Hospital, Beijing class: OTHER briefSummary: The short-term and long-term efficacy of recanalization therapy needs to be further confirmed by large-sample prospective studies. The comparison of success rate, complication rate and efficacy among the three recanalization modalities also needs to be further explored. The purpose of this cohort study is to observe the success rate, efficacy and safety of recanalization treatment for non-acute occlusion, and to further compare the advantages and disadvantages of CEA, endovascular intervention and hybrid surgery. conditions: Non-acute Carotid Artery Occlusion studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED name: Carotid Endarterectomy (CEA) name: Carotid Artery Stenting (CAS) name: Hybrid Surgery measure: Stroke or death whthin 30 days or recurrent ischemic stroke related of qualifying artery beyond 30 days through 12 months measure: MMSE within 30 and 90 days after procedure measure: MoCA scale within 30 and 90 days after procedure measure: Technical success rate measure: Procedural success rate measure: Any stroke within 30 days, 90 days and 12 months after procedure measure: Death within 30 days, 90 days and 12 months after procedure measure: Cranial nerve injury measure: Carotid artery or internal carotid artery reocclusion measure: Functional outcome measure: Other major complications sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Xuanwu Hospital, Capital Medical University status: RECRUITING city: Beijing state: Beijing zip: 100005 country: China name: Tao Wang, MD role: CONTACT phone: 18810302298 email: wangtao_dr@sina.com lat: 39.9075 lon: 116.39723 facility: Xuanwu Hospital, Capital Medical University. status: RECRUITING city: Beijing zip: 100053 country: China name: Liqun Jiao, Dr. role: CONTACT phone: 13911224991 email: liqunjiao@sina.cn lat: 39.9075 lon: 116.39723 hasResults: False
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<|newrecord|> nctId: NCT06303401 id: REC/MS-PT/01787 Gullalay briefTitle: Comparison of Thrust Manipulation of Sacroiliac Joint and Pelvic Stabilization Exercises in Post Partum Low Back Pain overallStatus: RECRUITING date: 2023-09-27 date: 2024-07-31 date: 2024-08-30 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: compare the effectiveness of SI joint thrust manipulation and pelvic stabilization exercises on Modified OSWESTRY Low Back pain Index (ODI) and Numeric Pain Rating Scale (NPRS) in patients with post-partum lower back pain. conditions: Low Back Pain, Post Partum studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 44 type: ESTIMATED name: SI joint thrust manipulation name: pelvic stabilization exercises measure: Numeric pain rating scale (NPRS) measure: Modified Oswestry Disability Index (ODI) sex: FEMALE minimumAge: 20 Years maximumAge: 40 Years stdAges: ADULT facility: Lady Reading Hospital and Shahab Orthopedic & General Hospital status: RECRUITING city: Peshawar state: KPK zip: 25000 country: Pakistan name: Asmar Fatima, MS OMPT role: CONTACT phone: 03336195644 email: asmar.fatima@riphah.edu.pk name: Gull alay, MS OMPT* role: PRINCIPAL_INVESTIGATOR name: Asmar Fatima, MS OMPT role: SUB_INVESTIGATOR lat: 34.008 lon: 71.57849 hasResults: False
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<|newrecord|> nctId: NCT06303388 id: REC/MS-PT/01721 briefTitle: Effects of Bruegger's Exercises Versus Egoscue Exercise on Lower Cross Syndrome overallStatus: RECRUITING date: 2024-02-26 date: 2024-05-30 date: 2024-06-15 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: This study aims to find effects of Bruegger's Exercise versus Egoscue exercise on pain and hyperlordosis on patient with lower cross syndrome. This is interventional study which recruits 34 participants ,14 in each group. conditions: Lower Cross Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 34 type: ESTIMATED name: Bruegger,s Exercise name: Egoscue Exercise measure: Flexicurve Ruler measure: Pelvic Inclinometer measure: NPRS measure: Modified Thomas Test measure: Visual Assessment through toe touching measure: Prone Hip Extension Co-ordination Test measure: Trunk Flexion Co-ordination and Strength Test sex: ALL minimumAge: 16 Years maximumAge: 65 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Pakistan Railway General Hospital status: RECRUITING city: Rawalpindi state: Federal zip: 44000 country: Pakistan name: Abdul Wasay, MS(SPT) role: CONTACT phone: 03345056564 name: Azka Batool, MS(OMPT) role: PRINCIPAL_INVESTIGATOR name: Nadia Ishtiaq, MS-OMPT role: SUB_INVESTIGATOR lat: 33.6007 lon: 73.0679 hasResults: False
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<|newrecord|> nctId: NCT06303375 id: REC/MS-PT/01718 Nida Kausar briefTitle: Effect of Kinesio Taping on Pain, Posture and Function in Lower Cross Syndrome overallStatus: RECRUITING date: 2023-10-13 date: 2024-07-31 date: 2024-08-30 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: Determine the impact of Kinesio taping on pain, postural alignment and functional outcomes in individuals with lower cross syndrome. conditions: Lower Cross Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 44 type: ESTIMATED name: Kinesio taping name: Conventional physical therapy measure: Visual analog scale (VAS) measure: Anterior pelvic tilting measure: Oswestry Disability Index (ODI) measure: Muscle Length sex: FEMALE minimumAge: 30 Years maximumAge: 50 Years stdAges: ADULT facility: Railway hospital Rawalpindi status: RECRUITING city: Rawalpindi state: Punjab zip: 46060 country: Pakistan name: Asmar Fatima, MS OMPT role: CONTACT phone: 03336195644 email: asmar.fatima@riphah.edu.pk name: Nida Kausar, MS OMPT* role: PRINCIPAL_INVESTIGATOR name: Asmar Fatima, MS OMPT role: SUB_INVESTIGATOR lat: 33.6007 lon: 73.0679 hasResults: False
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<|newrecord|> nctId: NCT06303362 id: REC/MS-PT/014258 Sumbal Nawaz briefTitle: Effects of Elastic Band Excercises on Chest Expansion overallStatus: COMPLETED date: 2023-08-01 date: 2024-01-30 date: 2024-01-30 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: • To determine the effects of Elastic Band Exercises on Chest Expansion, Forward Head Posture and disability conditions: Forward Head Posture studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR count: 28 type: ACTUAL name: Elastic band excercise name: strengthening with conventional physical therapy measure: Cloth tape measurement measure: Neck Disability Index measure: Craniovertebral angle sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Railway hospital Rawalpindi city: Rawalpindi state: Punjab zip: 46060 country: Pakistan lat: 33.6007 lon: 73.0679 hasResults: False
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<|newrecord|> nctId: NCT06303349 id: CHUBX 2023/45 briefTitle: Predictive Model for the Occurrence of Cerebral Vasospasm Complicating Subarachnoid Haemorrhage by Combined Analysis of the Kinetics of a Panel of Biomarkers. acronym: CVSBIODIAG overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-03 date: 2025-03 date: 2024-03-12 date: 2024-03-18 name: University Hospital, Bordeaux class: OTHER name: Bordeaux University briefSummary: The objective is to create a dynamic clinical prediction model that includes routinely measured care and biological biomarkers to predict cerebral vasospasm within 14 days of bleeding in patients treated in the neurosurgical intensive care unit for subarachnoid hemorrhage.
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Patients admitted to intensive care will be followed for up to 14 days (D14 time horizon of interest), or until discharge from intensive care if earlier.
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Blood samples will be taken from D1 to D10 to isolate the blood biomarkers of interest for each patient.
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The measurement of biomarkers and cerebral vasospasm will be blinded to each other. conditions: Cerebral Vasospasm studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective single-centre cohort study with prognostic aim, carried out in the neuro-resuscitation unit of the Bordeaux University Hospital. primaryPurpose: DIAGNOSTIC masking: NONE count: 150 type: ESTIMATED name: Samples collection measure: Occurrence of cerebral vasospasm measure: Biomarkers measurements measure: WFNS (World Federation of Neurologic Surgeons) score measure: Glasgow score measure: Medical Research Council (MRC) score measure: PtiO2 (oxygen pressure in the cerebral tissue) measure: Transcranial Doppler measure: Modified Fisher score measure: Non-significant angiographic vasospasm measure: Non-significant perfusion anomaly measure: Glasgow Outcome Scale -Extended (GOS-E) measure: Cerebral ischemic lesions measure: Occurrence of symptomatic vasospasm sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: CHU de Bordeaux city: Bordeaux country: France name: Grégoire CANE, Dr role: CONTACT phone: 0557821019 email: gregoire.cane@chu-bordeaux.fr name: Laure ESTEVE role: CONTACT phone: 0557821913 email: laure.esteve@chu-bordeaux.fr lat: 44.84044 lon: -0.5805 hasResults: False
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<|newrecord|> nctId: NCT06303336 id: REC/0258 Ayesha Ashraf briefTitle: Effects OF NMES With and Without Dynamic Bracing on Spasticity and Movement Quality in CP overallStatus: RECRUITING date: 2023-12-30 date: 2024-05-14 date: 2024-05-14 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: The study aims at comparing Neuromuscular electrical Stimulation with and without dynamic bracing on spasticity and movement quality of lower limb in Children with Cerebral Palsy conditions: Diplegic Spastic Cerebral Palsy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescription: participants and outcome assessors will be kept blind about the intervention which the patients will be receiving whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 42 type: ESTIMATED name: NMES with Dynamic Bracing name: NMES without Dynamic Bracing name: Dynamic Bracing Only measure: Modified Ashworth Scale measure: Observable Movement Quality Scale measure: Physicians Rating Scale sex: ALL minimumAge: 5 Years maximumAge: 12 Years stdAges: CHILD facility: Children Hospital status: RECRUITING city: Faisalābad state: Punjab zip: 54000 country: Pakistan name: Ammara Abbas, tDPT role: CONTACT phone: 03214932464 email: ammara.musvi@gmail.com name: Ayesha Ashraf, MS NMPT* role: PRINCIPAL_INVESTIGATOR lat: 31.41554 lon: 73.08969 hasResults: False
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<|newrecord|> nctId: NCT06303323 id: Nawal Fatima briefTitle: Comparative Effectiveness of Qigong Exercise Versus Wu Dang Tai Chi Chuan in CVD Risk Individuals overallStatus: RECRUITING date: 2024-03-15 date: 2024-07 date: 2024-08 date: 2024-03-12 date: 2024-04-03 name: Riphah International University class: OTHER briefSummary: To compare whether the Qigong exercise or Wu Dang Tai Chi Chuan will be effective in improving exercise capacity and reducing stress in CVD-risk individuals. Based on preliminary data, Qigong and Tai-Chi may help treat anxiety and depression symptoms in patients with chronic illnesses as well as in healthy adults. Without the need for specialized equipment, Qigong and Tai-Chi are both readily adjustable mind-body exercises that may be done whenever and wherever. For this reason, Qigong and TaiChi should be extensively encouraged as ways to enhance emotional wellbeing conditions: Cardiovascular Diseases conditions: Risk Behavior, Health studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 36 type: ESTIMATED name: Qigong Exercise name: Wu Dang Tai Chi measure: Exercise Capacity measure: Stress sex: ALL minimumAge: 30 Years maximumAge: 50 Years stdAges: ADULT facility: Pakistan Railway General Hospital status: RECRUITING city: Rawalpindi state: Punjab zip: 4600 country: Pakistan name: Mehwish Waseem, MSPT-CPPT role: CONTACT phone: 0331-5309015 email: mehwish.waseem@riphah.edu.pk name: Nawal Fatima, MSPT-CPPT* role: CONTACT phone: 0307 6500954 email: nawalfatima3@gmail.com lat: 33.6007 lon: 73.0679 hasResults: False
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<|newrecord|> nctId: NCT06303310 id: REC/RCR&AHS/23/0296 briefTitle: Comparative Effects Of Gaze Stability Exercises And Optokinetic Exercises In Patients With Vestibular Hypofunction overallStatus: RECRUITING date: 2024-02-20 date: 2024-05-01 date: 2024-05-15 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: This randomized clinical trial will occur at Bahawal Victoria Hospital, Bahawalpur within 7 months after the approval of synopsis. The sample size for this trial will be 40 participants. Participants fulfilling the inclusion criteria will be recruited by using the convenience sampling randomly allocated into two groups by computer generator method. 20 participants will be assigned to Group A receiving gaze stability exercises and 20 to the Group B receiving optokinetic exercises, both alongside routine physical therapy. Each group will undergo 5 weekly sessions of treatment for 4 weeks.The assessment tools include Dizziness Handicap Inventory for dizziness; Mini-BESTest and modified-Clinical Test of Sensory Interaction of Balance for balance assessment while Vestibular Disorders Activities of Daily Living Scale for daily activities. conditions: Vestibular Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Group A (Gaze Stability Exercises + Balance Exercises) Group B (Optokinetic Exercises + Balance Exercises) primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Assessor will be blinded. Assessor will be the person having 10 years experience in neuromuscular rehabilitation. whoMasked: OUTCOMES_ASSESSOR count: 40 type: ESTIMATED name: Gaze Stability Exercises name: Optokinetic Exercises name: Routine Physical Therapy measure: Dizziness Handicap Inventory measure: Mini-Bestest measure: Modified-Clinical Test of Sensory Interaction on Balance measure: Vestibular Disorders Activities of Daily Living Scale sex: ALL minimumAge: 20 Years maximumAge: 60 Years stdAges: ADULT facility: Bahawal Victoria Hospital status: RECRUITING city: Bahāwalpur state: Punjab zip: 63100 country: Pakistan name: Farrukh Rashid, MBBS, MCPS role: CONTACT phone: 03336390907 email: drfarrukhrashid@yahoo.com name: Tassaduq, MBBS, MCPS role: CONTACT phone: 03068200034 lat: 29.4 lon: 71.68333 hasResults: False
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<|newrecord|> nctId: NCT06303297 id: REC/RCR&AHS/23/0576 briefTitle: Effects of Reflexology and Generalized Stretching in Postmenopausal Females. overallStatus: RECRUITING date: 2023-11-23 date: 2024-08-01 date: 2024-09-01 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: To determine the combined Effects of reflexology and generalized stretching on insomnia, vasomotor symptoms and quality of life in postmenopausal females conditions: Postmenopausal Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 32 type: ESTIMATED name: REFLEXOLOGY name: GENERALIZED STRETCHING measure: Insomnia severity index score measure: Menopause Rating Scale measure: Menopause Specific Quality of Life sex: FEMALE minimumAge: 50 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Akhtar Saeed trust hospital, status: RECRUITING city: Lahore state: Punjab zip: 05499 country: Pakistan name: imran amjad role: CONTACT phone: 03324390125 email: imran.amjad@riphah.edu.pk name: Aneela Shahid, MSPT(WH) role: PRINCIPAL_INVESTIGATOR lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06303284 id: Pending briefTitle: Post-surgical Outcomes With Anabolic Agent Use in High-risk Ankle Fractures: A Pilot RCT overallStatus: NOT_YET_RECRUITING date: 2025-01-01 date: 2026-12-31 date: 2027-06-01 date: 2024-03-12 date: 2024-03-18 name: University of Calgary class: OTHER briefSummary: As the global population ages and the prevalence of poor bone health increases among older patients with ankle fractures, so does the risk of post-surgical complications. Prevention of post-surgical complications is of paramount importance to reducing morbidity, mortality, and healthcare costs.
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There is growing evidence to support the use of bone-building medications, such as Teriparatide, in patients who have delayed fracture healing or non-unions; however, these medications have yet to be investigated in elderly patients with ankle fractures at high risk for delayed fracture healing and post-operative complications. This project aims to assess the safety and efficacy of short-term Teriparatide use in improving outcomes in a population most likely to suffer post-operative complications.
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The proposed study is a pilot randomized controlled trial (RCT) with patients 60 years or older with an additional risk factor for delayed healing (i.e., osteoporosis, diabetes, vascular disease) who require ankle fracture surgery. Participants will be randomized to receive the study medication (Teriparatide) or placebo for three months. The primary objective of this study is to acquire vital data (i.e., recruitment rates, follow-up rates, adherence to treatment assignment) required to determine the feasibility of a full-scale multi-centre RCT. Additional aims are to evaluate repeat surgery, complications, time-to-union, and 90-day mortality. A complete a socio-economic and feasibility analysis will be completed.
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This study will evaluate the novel clinical approach of augmenting surgical fixation with a medication to build bone density and strength, thereby improving bone health, preventing complications, and improving outcomes. This study will also inform planning for a larger clinical trial to reduce the morbidity, mortality, and cost associated with complications in this high-risk population. conditions: Ankle Fractures studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: subcutaneous Teriparatide injection name: placebo measure: Participant recruitment rate measure: Incidence of composite measure of complications measure: Adverse events measure: modified Radiological Union Scale for Tibia [RUST] score), measure: Olerud Molander Score measure: EuroQol five dimensions [EQ-5D] measure: short form-12 [SF-12] measure: pain visual analogue score [VAS] measure: time-to-fracture union measure: 90 day mortality measure: Bone mineral density measure: Total cost and QALYs sex: ALL minimumAge: 60 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
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<|newrecord|> nctId: NCT06303271 id: MUHAMMAD NISAR briefTitle: Transcutaneous Auricular Vagus Nerve Stimulation on Dizziness & Balance in Elderly Population overallStatus: RECRUITING date: 2024-02-01 date: 2024-06-30 date: 2024-06-30 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: The objective of the study is to determine the effects of transcutaneous auricular vagus nerve stimulation on dizziness and balance on elderly population with unilateral vestibular hypofunction. Patients will be divided into experimental and control group. Randomized participants will be allocated into control and experimental group. Intervention Group A received Vagus Nerve Stimulation (VNS) and Caw Thorne Cooksey exercise while Group group B received Caw Thorne Cooksey exercise only. Both groups received intervention of 30 minutes daily for 4 weeks (16 sessions). Assessment was done at the baseline, after 2 weeks and after 4 weeks conditions: Vestibular Hypofunction studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 44 type: ESTIMATED name: Vagus Nerve Stimulation (VNS) and Caw Thorne Cooksey name: Caw Thorne Cooksey measure: The Dix-Hall pike test measure: Berg Balance Scale measure: The Dizziness Handicap Inventory (DHI) measure: Dynamic Gait Index (DGI) measure: Modified Clinical Test of sensory interaction & Balance (MCTSIB) sex: ALL minimumAge: 60 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: ENT dept. of DHQ Mirpur AJK status: RECRUITING city: Kashmir country: Pakistan name: Nadia Azhar, NMPT role: CONTACT phone: 03335281431 email: nadia.azhar@riphah.edu.pk hasResults: False
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<|newrecord|> nctId: NCT06303258 id: RiphahIU Sharmeen Kanwar briefTitle: Generalized Versus Core Stabilization Antenatal Exercises For Lumbopelvic Pain overallStatus: RECRUITING date: 2024-03-04 date: 2024-05-01 date: 2024-06-30 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: Core stability training has gained popularity as a fitness trend and is now being used in rehabilitation programs as well the patient adherence to this intervention has been low due to its complex nature, particularly pregnant females .Limited literature is available to present the effect of core stabilization exercises in comparison to the other handful simplified techniques and exercises This study compares two interventions for this particular condition to identify a feasible and enjoyable therapeutic intervention for the pregnant women who suffer Lumbopelvic Pain. conditions: Low Back Pain conditions: Pelvic Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Single (Outcomes Assessor) whoMasked: OUTCOMES_ASSESSOR count: 48 type: ESTIMATED name: Core Stabalization Exercises name: Generalized Antenatal Exercises measure: Visual Analogue Scale (VAS) measure: Visual Analogue Scale (VAS) measure: Pregnant women's quality of life questionnaire (QOL-GRAV) measure: Pregnant women's quality of life questionnaire (QOL-GRAV) sex: FEMALE minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Tehsil Headquarter Hospital Raiwind status: RECRUITING city: Lahore state: Punjab zip: 55150 country: Pakistan name: Sharmeen Kanwar, MS-WHPT* role: CONTACT phone: 0307-8778164 email: kanwarsharmeen@gmail.com lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06303245 id: REC/RCR&AHS/23/0579 briefTitle: Effects of Abdominal Binders and TENS on Puerperium Period After Cesarean Section overallStatus: RECRUITING date: 2023-02-23 date: 2024-08-01 date: 2024-09-01 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: To determine the combined effects of abdominal binders and TENS on post-operative pain, distress and constipation in puerperium period after cesarean section conditions: Cesarean Section; Complications, Wound, Dehiscence studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 28 type: ESTIMATED name: ABDOMINAL BINDERS name: TENS measure: o Numeric Pain rating Scale measure: o Symptom Distress scale measure: o PAC-SYM Questionnaire sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: PAF hospital status: RECRUITING city: Lahore zip: 05499 country: Pakistan name: imran amjad role: CONTACT phone: 03324390125 email: imran.amjad@riphah.edu.pk name: Mishal Jamal, MSPT(WH) role: PRINCIPAL_INVESTIGATOR lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06303232 id: REC/RCR&AHS/23/0578 briefTitle: Effects of Manual Lymphatic Drainage and Therapeutic Ultrasound on Breast Engorgement overallStatus: RECRUITING date: 2023-02-23 date: 2024-08-01 date: 2024-09-01 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: To find the combined effects of the manual lymphatic drainage with therapeutic ultrasound on breast engorgement, pain and self-efficacy in post - partum women. conditions: Postpartum Complication studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 42 type: ESTIMATED name: MANUAL LYMPHATIC DRAINAGE name: THERAPEUTIC ULTRASOUND measure: Visual Analogue Scale - VAS measure: Six Point Engorgement Scale - SPE measure: Breastfeeding Self-Efficacy Scale - BSES sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Innovative Health Concepts Clinic status: RECRUITING city: Lahore zip: 05499 country: Pakistan name: hina gul gul role: CONTACT phone: 03214979172 email: hina.gul@riphah.edu.pk name: Irsa Zahid, MSPT(WH) role: PRINCIPAL_INVESTIGATOR lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06303219 id: REC/RCR&AHS/23/0577 briefTitle: Effects of Traditional Moderate Intensity Training and High Intensity Interval Training in Polycystic Ovarian Syndrome overallStatus: RECRUITING date: 2023-11-23 date: 2024-08-01 date: 2024-09-01 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: To determine the comparative effects of traditional moderate intensity training and high intensity interval training on Anxiety, fatigue and Quality of Life in females with polycystic ovarian syndrome conditions: Polycystic Ovarian Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 44 type: ESTIMATED name: RADITIONAL MODERATE INTENSITY TRAINING name: HIGH INTENSITY INTERVAL TRAINING measure: Hamilton Anxiety Rating scale (HAM-A) measure: The Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (PCOSQ) measure: The Fatigue Impact Scale (FIS) sex: FEMALE minimumAge: 18 Years maximumAge: 35 Years stdAges: ADULT facility: Gynecological Department of Fatima Memorial Hospital status: RECRUITING city: Lahore zip: 05499 country: Pakistan name: hina gul gul role: CONTACT phone: 03214979172 email: hina.gul@riphah.edu.pk name: Fatima Kashif, MSPT(WH) role: PRINCIPAL_INVESTIGATOR lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06303206 id: H23-00623 briefTitle: TEC4Home Blood Pressure Randomized Controlled Trial overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2027-01-01 date: 2027-01-01 date: 2024-03-12 date: 2024-03-12 name: University of British Columbia class: OTHER briefSummary: The goal of this clinical trial is to evaluate the effect of home blood pressure telemonitoring (HBPT) and case management (CM), relative to usual care, for improving blood pressure (BP) control among patients with high blood pressure discharged from the emergency department (ED).
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The main question it aims to answer is: Does telemonitoring with case management improve BP control, relative to usual care, for people with high blood pressure discharged from the ED?
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Secondary research questions will address:
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1. How do these interventions (telemonitoring and case management) improve medication adherence?
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2. Do these interventions reduce physician and ED visits?
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3. Are these interventions safe?
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4. How do these interventions influence patient experience?
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Participants in the intervention group will receive training and use of a home BP telemonitor with tele-transmission function for 12-months plus pharmacist case management to provide behavioral counseling, facilitate medication adherence, review telemonitored BP data, and adjust medications. The control group will receive usual care from their primary care physician and will receive the same home BP monitor and hypertension education. conditions: Hypertension studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 408 type: ESTIMATED name: Home Blood Pressure Telemonitoring (HBPT) + Case Management (CM) measure: Systolic blood pressure controlled measure: Impact of intervention on other blood pressure measures sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
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<|newrecord|> nctId: NCT06303193 id: 10001554 id: 001554-C briefTitle: Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2030-01-01 date: 2035-01-01 date: 2024-03-12 date: 2024-04-26 name: National Cancer Institute (NCI) class: NIH briefSummary: Background:
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Myelodysplastic syndrome (MDS) and myelodysplastic/myeloproliferative neoplasm (MDS/MPN) are blood disorders that can cause serious complications in children and adults. MDS and MDS/MPN can also progress to acute myeloid leukemia. Treatments for these disorders are risky and not always effective. Better treatments are needed.
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Objective:
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To test a study drug (pacritinib) in adults and children with MDS or MDS/MPN.
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Eligibility:
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Children (aged 12 to 17 years) and adults (aged 18 years and older) with MDS or MDS/MPN.
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Design:
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Participants will be screened. They will have a physical exam with blood tests. They will have tests of their heart function. They may have a bone marrow biopsy: An area over the hip will be numbed; a needle will be inserted to remove a sample of soft tissue from inside the hipbone.
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Pacritinib is a capsule taken by mouth. All participants will take the study drug 2 times a day, every day, in 28-day cycles. They will write down the date and time they take each capsule. Doctors will assign varying dosages of the drug to different participants.
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Participants will have clinic visits each week during cycle 1; every 2 weeks during cycle 2; and gradually increasing to every 3 months after cycle 13. Treatment will continue for up to 8 years.
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Bone marrow biopsies, heart tests, and other tests will be repeated at intervals throughout the study. Participants will also fill out questionnaires about their quality of life, the symptoms of their disease, and other topics. conditions: Myelodysplastic Syndromes studyType: INTERVENTIONAL phases: PHASE1 phases: PHASE2 allocation: NON_RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 160 type: ESTIMATED name: pacritinib measure: Recommended phase 2 dose of pacritinib in participants 12-17 years of age measure: Efficacy as measured by Objective Response Rate (ORR) per each risk-based cohort measure: Pharmacokinetic (PK) properties of pacritinib measure: Extended safety of pacritinib sex: ALL minimumAge: 12 Years maximumAge: 120 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: National Institutes of Health Clinical Center city: Bethesda state: Maryland zip: 20892 country: United States name: National Cancer Institute Referral Office role: CONTACT phone: 888-624-1937 email: NCIMO_Referrals@mail.nih.gov lat: 38.98067 lon: -77.10026 hasResults: False
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<|newrecord|> nctId: NCT06303180 id: 10001560 id: 001560-DC briefTitle: NIDCD Otolaryngology Clinical Protocol Biospecimen Bank overallStatus: RECRUITING date: 2024-03-04 date: 2033-12-30 date: 2033-12-30 date: 2024-03-12 date: 2024-04-02 name: National Institute on Deafness and Other Communication Disorders (NIDCD) class: NIH briefSummary: Background:
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Many disorders of the head and neck can affect a person s hearing; balance; smell; taste; swallowing; voice; or speech. These disorders include cancers and genetic and inflammatory diseases. To find better ways to diagnose and treat these disorders, researchers need to study tissues and other biological samples from people who have them.
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Objective:
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To collect biological samples for a repository that will be used for research.
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Eligibility:
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People of any age with a disorder of the head and neck that requires the taking of biological samples. The conditions may be any that affect hearing; balance; smell; taste; swallowing; voice; or speech.
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Design:
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Part 1: Participants will give permission for their leftover tissue samples to be used for research. These are tissue samples from the head and neck that were collected in the course of routine tests and care or other research studies. Information on each participant s age, diagnosis, and previous treatments will also be collected.
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Part 2: Some participants may be asked for more samples. All those aged 3 years or older will have a physical exam. They will provide blood and saliva samples. A cotton swab or brush will be used to collect cells from the inside of the cheek.
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Participants 18 years or older may have additional tests. They may provide nasal secretions: A piece of gelfoam or a sponge will be placed in the nose to soak up secretions for 5 to 10 minutes. They may have biopsies: Small samples of tissue will be cut from the skin and the tissue lining the mouth.
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Samples may be used for genetic testing. conditions: Hearing Loss conditions: Head and Neck Neoplasms conditions: Hearing Disorders conditions: Laryngeal Disease studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 1000 type: ESTIMATED measure: To create a biorepository of diseased and normal tissue specimens for research purposes. measure: To share specimens with the NCI Frederick Patient-Derived Xenograft (PDX) team, other approved protocols or may be used under this protocol to conduct analysis of cellular, molecular, genetic and genomic biology of sex: ALL minimumAge: 3 Years maximumAge: 99 Years stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: National Institutes of Health Clinical Center status: RECRUITING city: Bethesda state: Maryland zip: 20892 country: United States name: Marcia Mulquin, RN, MSN role: CONTACT phone: 301-496-1601 email: mmulquin@mail.nih.gov name: NIH Clinical Center Office of Patient Recruitment (OPR) role: CONTACT phone: (800) 411-1222 phoneExt: TTY dial 711 email: ccopr@nih.gov lat: 38.98067 lon: -77.10026 hasResults: False
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<|newrecord|> nctId: NCT06303167 id: NCI-2024-01150 id: NCI-2024-01150 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: EAY131-E type: OTHER domain: ECOG-ACRIN Cancer Research Group id: EAY131-E type: OTHER domain: CTEP id: U10CA180820 type: NIH link: https://reporter.nih.gov/quickSearch/U10CA180820 briefTitle: Testing AZD9291 as Potentially Targeted Treatment in Cancers With EGFR Genetic Changes (MATCH-Subprotocol E) overallStatus: ACTIVE_NOT_RECRUITING date: 2015-08-06 date: 2024-05-26 date: 2024-05-26 date: 2024-03-12 date: 2024-03-12 name: National Cancer Institute (NCI) class: NIH briefSummary: This phase II MATCH treatment trial evaluates the effectiveness of osimertinib (AZD9291) in treating patients with cancer that has certain genetic changes called EGFR mutations. Osimertinib is in a class of medications called kinase inhibitors. It works by blocking the action of mutant forms of the EGFR protein, which play a key role in tumor cell growth. Osimertinib may cause tumor cell death and inhibit tumor growth in EGFR-overexpressing tumor cells, thereby stopping or slowing the spread of tumor cells. conditions: Advanced Lymphoma conditions: Advanced Malignant Solid Neoplasm conditions: Hematopoietic and Lymphoid Cell Neoplasm conditions: Refractory Lymphoma conditions: Refractory Malignant Solid Neoplasm conditions: Refractory Multiple Myeloma studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 35 type: ESTIMATED name: Biopsy name: Biospecimen Collection name: Echocardiography name: Multigated Acquisition Scan name: Osimertinib name: Radiologic Examination measure: Objective response rate measure: Overall survival measure: Progression free survival sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
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<|newrecord|> nctId: NCT06303154 id: EC45 MOBIBRA id: ID-RCB type: OTHER domain: 2023-A01937-38 briefTitle: Evaluation of Mobiderm Intimate Bra in the Management of Breast Edema Related to Breast Cancer Treatment acronym: MOBIBRA overallStatus: RECRUITING date: 2024-03-21 date: 2025-09 date: 2025-09 date: 2024-03-12 date: 2024-04-16 name: Thuasne class: INDUSTRY briefSummary: The aim of this exploratory study is to assess the performance and tolerability of the MOBIDERM Intimate Bra in the management of breast edema related to breast cancer treatment. conditions: Breast Cancer Surgery studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Prospective, exploratory, monocentric, uncontrolled clinical study. primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Mobiderm Intimate Bra group measure: Evolution of breast edema severity measure: Comparison of methods to follow changes in the severity of breast edema - TDC measurement measure: Comparison of methods to follow changes in the severity of breast edema - Clinical assessment measure: Comparison of methods to follow changes in the severity of breast edema - Ultrasound measurement measure: Time to edema onset measure: Time to edema disappearance measure: Symptoms and quality of life changes associated with breast edema measure: Breast edema hypersensitivity measure: Breast pain measure: Skin changes associated with breast edema measure: Physical activity measure: Healing time measure: Safety of the device measure: Compliance to the device measure: Patient's satisfaction sex: FEMALE minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Groupe Hospitalier Paris Saint Joseph - Groupement FEHAP status: RECRUITING city: Paris state: Paris 14 zip: 75014 country: France name: Séverine ALRAN, Dr role: CONTACT lat: 48.85341 lon: 2.3488 hasResults: False
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<|newrecord|> nctId: NCT06303141 id: LUC/CPGS/PGS/20230405/001 briefTitle: Comparative Effects of Neuromuscular Training and Mobilization With Movement in Professional Athletes With Ankle Sprain overallStatus: COMPLETED date: 2023-04-05 date: 2023-09-05 date: 2023-09-10 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: The study aims to compare the effects of neuromuscular training and mobilization with movement on pain, range of motion, function, and disability in professional athletes with ankle sprain. Neuromuscular training focuses on improving neuromuscular control and stability, while mobilization with movement aims to restore joint mobility and function. By investigating the outcomes of these two interventions, the study seeks to provide insights into their effectiveness for managing ankle sprains in professional athletes. conditions: Ankle Injuries conditions: Musculoskeletal Manipulations studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: the assessor who take the reading is blind whoMasked: OUTCOMES_ASSESSOR count: 60 type: ACTUAL name: Closed Chain exercises name: Neuromuscular Training name: Mobilization with Movement measure: Numerical Pain Rating Scale for Pain measure: Goniometer for Range of Motion measure: Star balance excursion test for Balance measure: Foot and ankle ability Measure for Functional Performance measure: Cumberland Ankle Instability measure: Agility T-test measure: Speed (20m sprint test) sex: ALL minimumAge: 18 Years maximumAge: 30 Years stdAges: ADULT facility: Pakistan Sports Board city: Lahore state: Punjab country: Pakistan lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06303128 id: IRB-FY2024-61 briefTitle: Penicillin Allergy Delabeling After a One-Dose Versus Two-Dose Graded Direct Oral Challenge overallStatus: RECRUITING date: 2024-02-03 date: 2024-12 date: 2025-05 date: 2024-03-12 date: 2024-03-15 name: James Tarbox, MD class: OTHER name: Texas Tech University Health Sciences Center briefSummary: The goal of this clinical trial is to learn about dosing when testing to see if a penicillin allergy label can be removed from adults that had been labeled as "penicillin-allergic" previously. The main question it aims to answer is:
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- In penicillin-allergic patients that are at low risk of having an allergic reaction, is a one-dose oral challenge with amoxicillin (a penicillin-based antibiotic) as safe and effective as a two-dose oral challenge?
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Participants will, after being identified as having a low-risk penicillin allergy, be administered oral amoxicillin in a controlled setting and then monitored for an allergic reaction. Researchers will compare participants that took one dose of amoxicillin to participants that took two doses of amoxicillin (a small dose and then a larger dose) to see if either group was more likely to develop an allergic reaction. conditions: Penicillin Allergy studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: - Low-risk penicillin allergic patients ("low-risk" determined by a PEN-FAST score of 2 or less) will be recruited. Clinically stable patients will be randomly assigned in a double-blinded manner to receive either a one-dose or graded two-dose direct oral challenge with amoxicillin in an outpatient setting. Those assigned to receive one dose of amoxicillin will receive a placebo in place of a second dose of amoxicillin. Both groups will receive the same cumulative dose of amoxicillin (250mg) by the end of the trial. Baseline vital signs will be obtained and tracked throughout the trial. Patients will also be monitored for development of signs of allergic reactions during the trial, with administration of appropriate treatment should the need arise. primaryPurpose: DIAGNOSTIC masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 380 type: ESTIMATED name: Amoxicillin 250 MG name: Placebo name: Amoxicillin 62.5mg name: Amoxicillin 187.5mg measure: Proportion of successfully "delabeled" subjects in one-dose versus two-dose groups measure: Analysis of adverse reactions measure: Analysis of medical and allergic history measure: Validation of penicillin allergy delabeling measure: Analysis of demographic data sex: ALL minimumAge: 18 Years maximumAge: 89 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Texas Tech University Health Sciences Center status: RECRUITING city: Lubbock state: Texas zip: 79430 country: United States name: Study Coordinator role: CONTACT phone: 806-543-8994 email: clinicalresearch@ttuhsc.edu name: Joshua A Peterson, MD role: CONTACT email: josh.peterson@ttuhsc.edu name: Joshua A Peterson, MD role: SUB_INVESTIGATOR name: Nicole Welch, MD role: SUB_INVESTIGATOR name: KaKa L Adams, MD role: SUB_INVESTIGATOR name: Barbara Mora Gonzalez, MD role: SUB_INVESTIGATOR name: Sebastian Sanchez Lopez, MD role: SUB_INVESTIGATOR name: Sierra Sullivan, MD role: SUB_INVESTIGATOR name: Jacob Nichols, MD role: PRINCIPAL_INVESTIGATOR name: James A Tarbox, MD role: PRINCIPAL_INVESTIGATOR lat: 33.57786 lon: -101.85517 hasResults: False
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<|newrecord|> nctId: NCT06303115 id: CSD231005 BoE briefTitle: CSD231005 Nicotine Pouch Biomarkers of Exposure overallStatus: NOT_YET_RECRUITING date: 2024-07-15 date: 2024-12-15 date: 2025-01-15 date: 2024-03-12 date: 2024-03-15 name: RAI Services Company class: INDUSTRY briefSummary: This will be a multi center open label, randomized, controlled, switching parallel-group study designed to assess changes in select biomarkers of exposure (BoE) in generally healthy smokers following a 5 day in-clinic switch to use of nicotine Pouch investigational products (IPs) compared to continued usual brand (UB) cigarette smoking or smoking abstinence. conditions: Tobacco Use conditions: Smoking studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: NONE count: 200 type: ESTIMATED name: Nicotine Pouch P1312914, 4 mg nicotine name: Nicotine Pouch P1312915, 8 mg nicotine name: Nicotine Pouch P1013215, 8 mg nicotine name: Nicotine Pouch P1013218, 10 mg nicotine name: Nicotine Pouch P1012919, 12 mg nicotine name: Smoking Abstinence name: Continued UB cigarette smoking measure: 4(methylnitrosamino)1(3pyridyl)1butanol [NNAL] + glucuronides [Total NNAL] measure: 4Aminobiphenyl [4ABP] measure: 1Aminonaphthalene [1AN] measure: 2Aminonaphthalene [2AN] measure: 2Cyanoethyl mercapturic acid [CEMA] measure: 3Hydroxypropyl mercapturic acid [3HPMA] measure: 3Hydroxy1methylpropylmercapturic acid [HMPMA] measure: 3hydroxybenzo[a]pyrene [3-OH-B[a]P] measure: 1hydroxypyrene [1OHP] measure: Monohydroxybutyl mercapturic acid [MHBMA] measure: Nnitrosonornicotine [NNN] + glucuronides [Total NNN] measure: SPhenyl mercapturic acid [SPMA] measure: Total nicotine equivalents (molar sum of nicotine, cotinine, 3hydroxycotinine and their glucuronides) [TNneq] measure: Carboxyhemoglobin [COHb] measure: Nnitrosonornicotine [NNN] + glucuronides [Total NNN] sex: ALL minimumAge: 21 Years maximumAge: 60 Years stdAges: ADULT facility: Pillar Bentonville city: Bentonville state: Arkansas zip: 72712 country: United States lat: 36.37285 lon: -94.20882 facility: AMR Lexington city: Lexington state: Kentucky zip: 40509 country: United States lat: 37.98869 lon: -84.47772 facility: QPS Missouri city: Springfield state: Missouri zip: 65802 country: United States lat: 37.21533 lon: -93.29824 facility: AMR Knoxville city: Knoxville state: Tennessee zip: 37920 country: United States name: William Smith, MD role: CONTACT lat: 35.96064 lon: -83.92074 facility: Pillar Richardson city: Richardson state: Texas zip: 75080 country: United States lat: 32.94818 lon: -96.72972 hasResults: False
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<|newrecord|> nctId: NCT06303102 id: REC/RCR&AHS/23/0356 briefTitle: Effects of Segmental and Pursed Lip Breathing Exercises on Upper Cross Syndrome overallStatus: COMPLETED date: 2023-05-23 date: 2024-01-30 date: 2024-02-15 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: Upper cross syndrome is relative prevalent 67% musculoskeletal disorder among general population due to increased usage of smart gadgets and poor postural habits. Upper cross syndrome is known for initiating malfunction of cervical and upper back muscles also associated with respiration. Individuals with upper cross syndrome may present with relaxed supine positioning, they may having normal respiratory mechanics but might be converted to accessory muscles activated pattern. Neck pain is the most common type of pain in non-traumatic conditions, affecting about 75.7% of people. The aim of this study is to compare the effects of segmental and pursed lip breathing exercises on pain, functional disability and quality of life in population with upper cross syndrome.
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Current study will be randomized controlled trial conducted at Ismail Medicare Jhang, 40 patients according to inclusion criteria will be included in the study. They will be allocated into 2 groups by non-probability purposive sampling technique. Group A (control group) will receive conventional physical therapy treatment (hot pack, electrical stimulation, myofascial release, ROM and strengthening exercises) while Group B (experimental group) receive conventional physical therapy treatment with segmental and pursed lip breathing exercises. Outcome measures are Pain Numeric Scale, Quality of life (SF 36) and Functional disability (neck disability index). These tools will measure neck function and neck pain intensity. Treatment time will be 4 weeks, 3 sessions per week, each session will be 45 minutes long, and measurements will be taken after 4 weeks. Data will be analyzed by SPSS version 25. After assessing normality of data by Shapiro - wilk test, it will be decided either parametric or non-parametric test will be used within a group or between two groups analysis.
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Key Words: Breathing Exercises, Cervical Pain, Disability, Upper Cross conditions: UPPER CROSS SYNDROME studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 40 type: ACTUAL name: Manual PT/ Conventional PT Treatment + Segmental and Pursed Lip Breathing Exercise name: Manual PT/Conventional PT Treatment measure: NPRS measure: Quality of Life (SF-36 questionnaire) measure: Neck Disability Index (NDI) sex: ALL minimumAge: 25 Years maximumAge: 40 Years stdAges: ADULT facility: Ismail Medicare city: Jhang state: Punjab zip: 35200 country: Pakistan hasResults: False
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<|newrecord|> nctId: NCT06303089 id: zzwee-quit (CKD) 23152 briefTitle: Tobacco Exposure and Influencing Factors of Smoking Cessation Among Chronic Kidney Disease Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-01-01 date: 2025-03-01 date: 2024-03-12 date: 2024-03-12 name: Sun Yat-sen University class: OTHER briefSummary: The purpose of this study is to describe the tobacco exposure and characteristics of patients with Chronic Kidney Disease (CKD) who quit smoking, to identify patients' tobacco-related knowledge, attitude, and practice (KAP) and explore the influencing factors of smoking cessation. conditions: Smoking Cessation studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: CROSS_SECTIONAL count: 554 type: ESTIMATED name: Questionnaires set measure: Prevalence of current smokers measure: Abstinence rates measure: Nicotine dependence measure: Perceptions of tobacco harm measure: knowledge of tobacco-related diseases measure: Smoking related attitudes measure: Self-efficacy level measure: Withdrawal symptoms sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: XIAW city: Guangzhou state: Guangdong zip: 510080 country: China name: Wei Xia, PhD role: CONTACT phone: 18823359471 email: xiaw23@mail.sysu.edu.cn lat: 23.11667 lon: 113.25 hasResults: False
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<|newrecord|> nctId: NCT06303076 id: 134 briefTitle: Tizanidine vs. Zolpidem in Primary Insomnia: A Randomized Trial overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2026-09 date: 2026-12 date: 2024-03-12 date: 2024-03-12 name: Sultan Qaboos University class: OTHER briefSummary: The study's primary objective is to evaluate the effectiveness of Tinazidine compared to Zolpidem in enhancing sleep quality, with secondary objectives including the assessment of adverse effects, safety profile, and patient tolerance with each treatment. The trial will be conducted as a double-blind RCT, with participants randomly assigned to receive either Tinazidine (0.1 mg/Kg/HS) or Zolpidem 10 mg HS, for 12 weeks. Eligible participants, aged 18-60 years, diagnosed with primary insomnia as per DSM-5 criteria, will be recruited from an outpatient sleep clinic affiliated with Al-Masara Hospital. Data on sleep quality, and side effects, will be collected using the Sleep Pittsburgh Sleep Quality Index (PSQI), Clinical Global Impression (CGI), sleep diaries, actigraphy, polysomnography, and regular clinical interview though OPD follow-up visits. The primary outcome considered was the mean global PSQI score before and after the treatment. The primary outcome will be measured four times (baseline, 4 weeks, 8 weeks, and 12 weeks), We considered an attrition rate (dropout/lost follow-up) of 10%. Therefore, the sample size is 90 subjects (45 in each group). Group comparisons for mean scores will be conducted using independent samples t-tests, and within-group comparisons will be assessed using paired samples t-tests. Changes in sleep quality over time between treatment groups will be evaluated using repeated measures ANOVA. Associations between categorical variables will be examined using Chi-square tests (including Fisher's exact or Likelihood ratio tests as appropriate). Statistical significance will be considered for p-values less than 0.05. All analyses will be performed using IBM SPSS Statistics (Version 29.0). The findings of this study seek to elucidate the comparative efficacy and safety profiles of Tizanidine and Zolpidem in treating primary insomnia. The study aims to offer insights into the effectiveness of Tizanidine versus Zolpidem in improving sleep quality among patients with primary insomnia. Through the evaluation of efficacy, adverse effects, and safety profiles. This study aims to inform clinicians and healthcare practitioners about the optimal treatment choices for individuals with primary insomnia. conditions: Depressive Disorder, Major studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 90 type: ESTIMATED name: Tizanidine Hcl 4Mg Tab name: Zolpidem Tartrate 10 mg measure: Pittsburgh Sleep Quality Index measure: Frequency and Severity of Side Effects sex: ALL minimumAge: 18 Years maximumAge: 60 Years stdAges: ADULT hasResults: False
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<|newrecord|> nctId: NCT06303063 id: SNSC-IAS-202301 briefTitle: Compare the Safety and Effectiveness of Two Different Kinds of Stent System in Intracranial Aneurysms overallStatus: RECRUITING date: 2024-01-17 date: 2025-06-30 date: 2025-12-30 date: 2024-03-12 date: 2024-04-01 name: Sinomed Neurovita Technology Inc. class: INDUSTRY briefSummary: The primary objective of this trial is to evaluate the safety and efficacy of SINOMED IAS in patients with intracranial aneurysms. conditions: Intracranial Aneurysm studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 204 type: ESTIMATED name: SINOMED IAS Stent System name: Neuroform Atlas Stent System measure: Success aneurysm occlusion at 6 month post procedure measure: Technical success measure: Success aneurysm occlusion immediately after the procedure measure: Complete aneurysm occlusion without significant parent artery stenosis (≤50%) or retreatment at 6 months post procedure measure: Complete aneurysm occlusion at 6 months post procedure measure: Retreatment Rate at 6 months and 1 year post procedure measure: In-Stent Stenosis at 6 months post procedure measure: Modified Rankin Scale (mRS) at 30 days, 6 months and 1 year post procedure measure: Major ipsilateral stroke at 30 days, 6 months and 1 year post procedure measure: All-cause mortality at 30 days, 6 months and 1 year post procedure measure: Incidence of adverse events/serious adverse events during 30 days, 6 months and 1 year post procedure measure: In-stent thrombosis at 6 months post procedure measure: Rate of Device defect sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Beijing Tiantan Hospital, Capital Medical University status: RECRUITING city: Beijing country: China name: Jianxin Yang role: CONTACT phone: 010-59978595 email: yangxinjian@voiceoftiantan.org lat: 39.9075 lon: 116.39723 hasResults: False
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<|newrecord|> nctId: NCT06303050 id: Urooj Amir briefTitle: Additional Effects of Mental Imagery Along With Task Oriented Training on Kinesiophobia in Patients With Stroke overallStatus: RECRUITING date: 2023-12-07 date: 2024-06-07 date: 2024-06-07 date: 2024-03-12 date: 2024-03-12 name: Riphah International University class: OTHER briefSummary: The objective of this study to determine the effect of mental imagery and task oriented training on Kinesiophobia in stroke patients. And to determine the association of Kinesiophobia with gait and balance in stroke patients. Patients will be divided into experimental and control group. Randomized participants will be allocated into control and experimental group. The experimental group will receive 20 minutes of MI training followed by 25 minutes of TOT for a total of 45 minutes, 5 days per week for 6 weeks. conditions: Stroke, Cardiovascular studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 44 type: ESTIMATED name: Mental Imagery with task Oriented training group name: Task Oriented training group measure: Berg And Balance scale measure: Tempa scale for kinesiophobia measure: Ten-meter walk test measure: Dynamic gate index measure: Time Up and Go Test sex: ALL minimumAge: 45 Years maximumAge: 60 Years stdAges: ADULT facility: Khyber Medical University status: RECRUITING city: Peshawar state: KPK zip: 2500 country: Pakistan name: Nadia Azhar, NMPT role: CONTACT phone: 03335281431 email: nadia.azhar@riphah.edu.pk lat: 34.008 lon: 71.57849 hasResults: False
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<|newrecord|> nctId: NCT06303037 id: SAHoWMU-CR2024-03-105 briefTitle: Effect of Esketamine on 95% Induction Dose of Remimazolam acronym: EEIDR overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-02 date: 2025-03 date: 2024-03-12 date: 2024-03-12 name: Second Affiliated Hospital of Wenzhou Medical University class: OTHER briefSummary: As an invasive operation, gastroscopy will cause children's nervousness, anxiety and uncooperative behavior, and even lead to the risk of bleeding and perforation, which will also affect the accuracy of the examination results.The purpose of this study is to explore the influence of different doses of esketamine on the induced dose ED95 of remazolam during gastroscopic placement in children, and to provide theoretical basis for the combined use of remimazolam besylate and esketamine in gastroscopic anesthesia in children. conditions: Pediatric conditions: Gastroscopy conditions: ED95 conditions: Sedation studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 80 type: ESTIMATED name: Remimazolam besylate and low-dose Esketamine name: Remimazolam besylate and Medium dose Esketamine measure: Sedation induction time measure: Modified observer's assessment of alertness#sedation#MOAA/S#scale measure: Recovery times measure: VAS(The difficulty of gastroscope insertion) measure: Number of children with adverse effects sex: ALL minimumAge: 3 Years maximumAge: 12 Years stdAges: CHILD facility: The second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University city: Wenzhou state: Zhejiang country: China lat: 27.99942 lon: 120.66682 hasResults: False
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<|newrecord|> nctId: NCT06303024 id: RELIABLE Clinical Study briefTitle: Targeting Subclinical Motor and Cognitive Impairment in Patients With Early Onset Multiple Sclerosis acronym: RELIABLE overallStatus: RECRUITING date: 2023-06-14 date: 2024-03-01 date: 2026-03-01 date: 2024-03-12 date: 2024-03-12 name: Fondazione Don Carlo Gnocchi Onlus class: OTHER name: Careggi Hospital name: Sheba Medical Center name: Uppsala University briefSummary: Our project proposal is based on an individualized rehabilitation approach in patients with early stage relapsing remission (RR) MS. This approach will be based on risk stratification obtained using several clinical and demographic parameters that are not commonly used in clinical practice. This risk score will be obtained from an extensive neuropsychological, psychosocial and physical assessment to which patients will undergo at baseline and at one-year follow-up.The risk score will allow a better stratification of patients' risk of disease worsening/progression and the application of a preventive and personalized strategy. conditions: Multiple Sclerosis, Relapsing-Remitting studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SEQUENTIAL interventionModelDescription: This is a multicentric no-profit pilot study, composed by two phases. I phase: observational prospective study II phase: interventional study primaryPurpose: TREATMENT masking: NONE count: 140 type: ESTIMATED name: personalized combined physical and cognitive intervention measure: Symbol Digit Modalities Test (SDMT) measure: California Verbal Learning Test second edition (CVLT-II) measure: Brief Visuo-Spatial Memory Test- Revised (BVMT-R) measure: Word list generation (WLG) measure: Stroop test measure: Test Intelligenza Breve (TIB) measure: 9 hole peg test (9HPT) measure: The Hospital Anxiety and Depression Scale (HADS) measure: Beck Depression Inventory second edition measure: The Modified Fatigue Impact Scale (MFIS) measure: The Multiple Sclerosis Walking Scale (MSWS-12) measure: Multiple Sclerosis Impact Scale (MSIS-29-V2) measure: Multiple Sclerosis Quality of Life-54 (MSQOL-54) measure: six minutes walking test (6MWT) measure: Romberg test measure: handgrip test measure: cognitive-motor interference measure: Timed 25-foot walk measure: brain MRI scan measure: International Physical Activity Questionnaire (IPAQ) sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: IRCCS Fondazione Don Carlo Gnocchi ONLUS status: RECRUITING city: Firenze zip: 50143 country: Italy name: Maria Pia Amato, Prof role: CONTACT phone: 0557947836 email: mpamato@dongnocchi.it lat: 43.77925 lon: 11.24626 hasResults: False
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<|newrecord|> nctId: NCT06303011 id: S22C14G92003 briefTitle: Abdominal Massage With TENS on Parasacral Versus Sacral Area on Symptom,Severity & QOL in Chronic Constipation Females. overallStatus: COMPLETED date: 2023-03-15 date: 2024-03-15 date: 2024-03-15 date: 2024-03-12 date: 2024-04-22 name: Riphah International University class: OTHER briefSummary: Constipation is Infrequent or difficult evacuation of FECES. These symptoms are associated with a variety of causes, including low DIETARY FIBER intake, emotional or nervous disturbances, systemic and structural disorders, drug-induced aggravation, and infections. Patients complaining of constipation may mean different things by the term The frequency of their bowel actions may be less than 'normal', their stools maybe difficult to pass, or they may have a sense of malaise or abdominal discomfort which they attribute to a 'sluggish bowel', though the stool frequency and consistency are apparently normal. Objective of this study is to compare effects of Abdominal massage. withTENSonparasacralversussacralareaonsymptomseverityandqualityoflifein severechronicconstipationamongyoungfemales. conditions: Constipation studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 26 type: ACTUAL name: Transcutaneous Electrical Nerve Stimulator name: TENS on para sacral area with Abdominal Massage measure: PAC-SYM Questionnaire measure: PAC-QOL Questionnaire sex: FEMALE minimumAge: 14 Years maximumAge: 35 Years stdAges: CHILD stdAges: ADULT facility: Jinnah Hospital city: Lahore state: Punjab zip: 44000 country: Pakistan lat: 31.558 lon: 74.35071 hasResults: False
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<|newrecord|> nctId: NCT06302998 id: MS.111 briefTitle: Dexmedetomidine and Vasopressin in Septic Shock acronym: DecatSepsis-2 overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-01 date: 2024-03-12 date: 2024-03-12 name: Mansoura University class: OTHER briefSummary: Rudiger and Singer suggested strategies for refining adrenergic stress (decatecholaminization). They proposed the use of dexmedetomidine and vasopressin to reduce the catecholamine load during sepsis. The investigators will use vasopressin as the primary vasopressor and a heart rate-calibrated dexmedetomidine infusion in septic shock patients.
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The investigators of the current study will use DEXPRESSIN in septic shock patients to investigate the effects of decatecholaminization on in-hospital mortality. conditions: Sepsis conditions: Septic Shock studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized controlled superiority trial primaryPurpose: TREATMENT masking: SINGLE maskingDescription: The outcome assessor will be nurses - not invovled in the study - will be unware about the study drug. whoMasked: OUTCOMES_ASSESSOR count: 260 type: ESTIMATED name: DEX-PRESSIN name: Standard of Care measure: in-hospital mortality measure: survival analysis measure: Norepinephrine Equivalent Dose (NED) measure: Duration of vasopressor infusion in survivors measure: Initiation of invasive mechanical ventilation (IMV) measure: Duration of IMV measure: Early acute kidney injury (AKI) measure: Late acute kidney injury (AKI) measure: Acute Physiology and Chronic Health Evaluation (APACHE-II) measure: Simplified Acute Physiology Score (SAPS) II score measure: ICU length of stay measure: Hospital length of stay sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
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<|newrecord|> nctId: NCT06302985 id: ICG-CLMs briefTitle: Atomized Inhalation ICG for Treatment of Congenital Lung Malformations overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2050-12-31 date: 2050-12-31 date: 2024-03-12 date: 2024-03-12 name: Jiexiong Feng class: OTHER briefSummary: To investigate the safety and effectiveness of preoperative aerosol inhalation ICG solution for thoracoscopic accurate resection of congenital lung malformations in children. conditions: Pulmonary Sequestration conditions: Congenital Pulmonary Airway Malformation conditions: Indocyanine Green conditions: Thoracoscopic Surgery conditions: Children studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMENT masking: NONE count: 50 type: ESTIMATED name: atomized inhalation ICG before thoracoscope pneumonectomy measure: rate residual measure: peak volume ratio measure: length of hospital stay measure: peak time ratio sex: ALL minimumAge: 3 Months maximumAge: 14 Years stdAges: CHILD facility: Tongji Hospital city: Wuhan state: Hubei zip: 430030 country: China lat: 30.58333 lon: 114.26667 hasResults: False
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<|newrecord|> nctId: NCT06302972 id: RCRAHS-ISB/REC/MS-PT/01771 briefTitle: Effects of IASTM Along With Comprehensive Corrective Exercise Program in Upper Cross Syndrome. overallStatus: RECRUITING date: 2023-10-30 date: 2024-06-30 date: 2024-06-30 date: 2024-03-12 date: 2024-04-19 name: Riphah International University class: OTHER briefSummary: This study will see the effects of IASTM along with comprehensive corrective exercise program in upper cross syndrome through their effects on pain and cervical ranges as well as postural improvement. Our study targets both male and female population. In the reference study only male population was targeted which did not show effects of both techniques on the female population though females have high stress levels which may alter results. conditions: Upper Cross Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Participants were randomly assigned to the experimental group or control group after a baseline assessment with sealed enveloped method. Each participant took a envelope that identified their group and gave it to the researchers without seeing what was written. Participants were not notified which group was assigned to. primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Participants were informed that they would receive treatment either from group 1 or group 2 without indicating which group should undergo IASTM and comprehensive corrective exercise program and which group undergo only comprehensive corrective exercise program whoMasked: PARTICIPANT count: 44 type: ESTIMATED name: Traditional treatment name: IASTM and CCEP measure: Range of motion Cervical (Flexion) measure: ROM Cervical (Extension) measure: ROM Cervical (Left Lateral Flexion) measure: ROM Cervical( Right Lateral Flexion) measure: ROM Cervical ( Right Rotation) measure: ROM Cervical ( Left Rotation) measure: Numeric Pain Rating Scale (NPRS) measure: Flexicurve Ruler and Photogrammetry for posture sex: ALL minimumAge: 18 Years maximumAge: 40 Years stdAges: ADULT facility: Maroof international Hospital and Railway Hospital status: RECRUITING city: Islamabad state: Federal zip: 44000 country: Pakistan lat: 33.72148 lon: 73.04329 hasResults: False
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<|newrecord|> nctId: NCT06302959 id: 36-232 ex 23/24 briefTitle: Clock Proteins as Prognostic Markers acronym: CLOCK-PM overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-03-31 date: 2027-12-31 date: 2024-03-12 date: 2024-03-29 name: Medical University of Graz class: OTHER briefSummary: Asthma is a chronic inflammatory disease of the airways that follows a strong circadian rhythm: Signs of inflammation and symptoms worsen especially in the early morning hours. The molecular circadian clock, which is a complex machinery of transcriptional and translational feedback loops, seems to reflect the inflammatory environment of peripheral blood leukocytes. Therefore, in this observational study the investigators will monitor the molecular circadian clock in patients with severe eosinophilic asthma before and during mepolizumab treatment. Our major goal is to evaluate the potential of the molecular circadian clock to serve as a prognostic marker for disease progression, treatment response or remission in patients with severe eosinophilic asthma. The molecular circadian clock will be monitored in blood and sputum leukocytes from patients with severe eosinophilic asthma before mepolizumab treatment, after 4 month of mepolizumab therapy, and once they reach remission under mepolizumab treatment. Effects will be compared to healthy controls and patients with mild-moderate asthma without mepolizumab treatment. conditions: Severe Eosinophilic Asthma studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 100 type: ESTIMATED measure: Correlation between clock expression, exacerbation rate and lung function. measure: Correlation between clock expression, symptoms and quality of life. sex: ALL minimumAge: 18 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
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<|newrecord|> nctId: NCT06302946 id: P.T.REC/012/005024 briefTitle: Effect of Neuromuscular Stimulation and Mindfulness Breathing in Patients With Stroke overallStatus: RECRUITING date: 2024-03-15 date: 2025-05-30 date: 2025-12-30 date: 2024-03-12 date: 2024-03-12 name: Cairo University class: OTHER briefSummary: It is an interventional study in which 60 stroke patients estimated to enroll according to random allocation and divided into two groups. The experimental group will receive neuromuscular stimulation , mindfulness breathing and traditional physiotherapy while the control group will stick to traditional physiotherapy only. conditions: Stroke studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE whoMasked: PARTICIPANT whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: neuromuscular stimulation ,mindfulness breathing and traditional physiotherapy program name: traditional physiotherapy program measure: level of physical function measure: ventilatory function measure: level of stress sex: ALL minimumAge: 50 Years maximumAge: 65 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Faculty of Physical Therapy status: RECRUITING city: Cairo state: Dokki zip: 11432 country: Egypt name: marwa M elsayed, phd role: CONTACT phone: 01156033818 phoneExt: 02 email: marwadd999@gmail.com name: marwa M elsayed, ph.d role: CONTACT phone: 01156033818 phoneExt: 02 email: marwadd999@gmail.com lat: 30.06263 lon: 31.24967 hasResults: False
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<|newrecord|> nctId: NCT06302933 id: ANRS 12414 PediacamNEG briefTitle: Negative Serology by Immunoenzymatic Test (EIA) in HIV-infected Children Treated Early With Antiretroviral in the ANRS-Pediacam Study: Pathophysiological Mechanisms acronym: PediacamNEG overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-08-30 date: 2025-08-30 date: 2024-03-12 date: 2024-03-12 name: ANRS, Emerging Infectious Diseases class: OTHER_GOV name: Centre Pasteur du Cameroun name: Centre Mère et Enfant de la Fondation Chantal Biya name: Centre Hospitalier D'essos name: Hospital General De Douala name: Centre Hospitalier Universitaire d'Orléans name: Institut Pasteur name: Hopital Universitaire Robert-Debre name: Université Paris-Sud briefSummary: The objective of the study is to identify the pathophysiological mechanisms responsible for the induction and maintenance of negative serologies by EIA tests in HIV-infected children treated early with HAART in the ANRS 12225-Pediacam III cohort in Cameroon
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The hypothesis of better control of HIV infection through interactions between immunological, viral, and genetic factors was made to build the following objectives:
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* Immunological aspect: lack of humoral response or immune activation
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* Virological aspect: Reduced HIV reservoir size
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* Determine the HLA phenotype in the different groups of children included and the KIR genotypes. conditions: HIV Infections studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: Study type: a study nested in the ANRS 12225 - Pediacam III cohort, comprising two phases
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* A retrospective phase: case-control study The analyzed data are those collected previously or measured from the already available bio bank, within the framework of the Pediacam III cohort during the primary infection phase before the initiation of HAART, at 6 months after the end of the first series of EPI vaccines, and at 2 years.
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* A prospective phase: cross-sectional study Based on an ad hoc bio bank created for parameters we couldn't measure on the existing bio bank primaryPurpose: HEALTH_SERVICES_RESEARCH masking: NONE count: 451 type: ESTIMATED name: Blood sampling measure: Level of pro-inflammatory and anti-inflammatory cytokines, chimiokines in the plasma measure: Level of pro-inflammatory and anti-inflammatory cytokines, chimiokines in the plasma measure: Level of pro-inflammatory and anti-inflammatory cytokines, chimiokines in the plasma measure: Level of pro-inflammatory and anti-inflammatory cytokines, chimiokines in the plasma measure: Level of pro-inflammatory and anti-inflammatory cytokines, chimiokines in the plasma measure: Level of pro-inflammatory and anti-inflammatory cytokines, chimiokines in the plasma measure: Level of pro-inflammatory and anti-inflammatory cytokines, chimiokines in the plasma measure: - Humoral response to vaccines against tetanus, pertussis, and viral hepatitis B measure: - Functional and phenotypic characterization of B and T lymphocytes measure: - Size of the HIV reservoir measure: - Residual viremia in perinatally HIV-infected adolescent measure: - Level of HIV plasma p24 measure: - HLA phenotype and the KIR genotypes sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT facility: Centre Pasteur Cameroun city: Yaounde zip: 1274 country: Cameroon name: Mathurin C Tejiokem role: CONTACT phone: +237222231803 email: tejiokem@pasteur-yaounde.org lat: 3.86667 lon: 11.51667 hasResults: False
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<|newrecord|> nctId: NCT06302920 id: 0001 briefTitle: Effect of Kinesiotaping on Pain,Edema and Kinesiophobia in Patients With Complex Regional Pain Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-05-20 date: 2024-06-20 date: 2024-12-20 date: 2024-03-12 date: 2024-03-12 name: Alanya Alaaddin Keykubat University class: OTHER briefSummary: Patients will be divided into 2 groups according to the random numbers table, and both groups will receive a conventional physical therapy and rehabilitation program and nutritional support. Afterwards, edema-reducing kinesiotaping will be applied to one group. The applied kinesio tape will remain on the patient for 5 days and will be taped again after 2 days without tape. In this way, taping will be done 3 times in total, once a week for 3 weeks. During this period, patients will continue their routine physical therapy program and measurements will be taken by the same researcher in the 1st week of treatment and 3 weeks later. conditions: Complex Regional Pain Syndrome Type I studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: OUTCOMES_ASSESSOR count: 60 type: ESTIMATED name: Kinesiotape measure: Resting pain measure: Edema measure: Kinesiophobia sex: ALL minimumAge: 18 Years maximumAge: 80 Years stdAges: ADULT stdAges: OLDER_ADULT facility: Alanya Alaaddin Keykubat University city: Antalya country: Turkey name: Deniz Bulut role: CONTACT phone: +90 05059445604 email: denizhava1988@gmail.com name: Deniz Bulut role: PRINCIPAL_INVESTIGATOR name: İsmet Aslı Topcuoğlu role: PRINCIPAL_INVESTIGATOR lat: 36.90812 lon: 30.69556 hasResults: False
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<|newrecord|> nctId: NCT06302907 id: M/45- 14.1.2023 briefTitle: The Effect of Adding Sodium Bicarbonate 8.4% to Local Anesthesia on Pain During Upper Canine Infiltration overallStatus: ENROLLING_BY_INVITATION date: 2023-01-14 date: 2023-09-10 date: 2024-06-30 date: 2024-03-12 date: 2024-03-12 name: Al-Wataniya University class: OTHER briefSummary: The aim of the present study was to evaluate the pain during local anesthetic buccal infiltration for the maxillary canines after adding Sodium Bicarbonate 8.4% during local anesthesia. conditions: Local Anesthetic Complication studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE whoMasked: PARTICIPANT count: 30 type: ESTIMATED name: Buffered Local anaesthesia name: Unbuffered Local anaesthesia measure: Pain on injection sex: ALL minimumAge: 15 Years maximumAge: 50 Years stdAges: CHILD stdAges: ADULT facility: Al Wataniya Private University city: Hama state: Hama Government zip: 00000 country: Syrian Arab Republic lat: 35.13179 lon: 36.75783 hasResults: False
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<|newrecord|> nctId: NCT06302894 id: BAIBU-SBF-EC-01 briefTitle: The Effect of the Nursing Intervention Program on Adolescent Problematic Internet Users overallStatus: ENROLLING_BY_INVITATION date: 2024-03-01 date: 2024-10-01 date: 2024-12-31 date: 2024-03-12 date: 2024-03-12 name: Abant Izzet Baysal University class: OTHER briefSummary: In this study; The effect of the nursing intervention program (education enriched with web 2.0 tools based on the Health Belief Model) on problematic internet use, loneliness and family harmony in adolescents who use the internet with problems will be determined. conditions: Internet Addiction Disorder studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: SINGLE whoMasked: PARTICIPANT count: 1000 type: ESTIMATED name: Self-sufficiency measure: Internet Addiction Scale sex: ALL minimumAge: 12 Years maximumAge: 18 Years stdAges: CHILD stdAges: ADULT facility: Bolu Abant İzzet Baysal University Faculty of Health Sciences city: Bolu zip: 14300 country: Turkey lat: 40.73583 lon: 31.60611 hasResults: False
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<|newrecord|> nctId: NCT06302881 id: liaohongfan briefTitle: Differentiating Tumor-stroma Ratio in Pancreatic Ductal Adenocarcinoma overallStatus: ACTIVE_NOT_RECRUITING date: 2013-01 date: 2022-07 date: 2024-03 date: 2024-03-12 date: 2024-03-12 name: First Affiliated Hospital of Chongqing Medical University class: OTHER briefSummary: This study introduces a novel transfer learning-based contrastive language-image pretraining adapter (CLIP-adapter) model for predicting the tumor-stroma ratio (TSR) in pancreatic ductal adenocarcinoma (PDAC) using preoperative dual-phase CT images. The primary aim is to develop an efficient and accessible tool for risk stratification and personalized treatment planning. conditions: Pancreatic Ductal Adenocarcinoma studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 207 type: ACTUAL measure: The diagnostic AUC value of pancreatic ductal adenocarcinoma with deep learning algorithm. measure: The diagnostic accuracy of pancreatic ductal adenocarcinoma with deep learning algorithm. measure: The diagnostic sensitivity of pancreatic ductal adenocarcinoma with deep learning algorithm. measure: The diagnostic specificity of pancreatic ductal adenocarcinoma with deep learning algorithm. measure: The diagnostic positive predictive value of pancreatic ductal adenocarcinoma with deep learning algorithm. measure: The diagnostic negative predictive value of pancreatic ductal adenocarcinoma with deep learning algorithm. sex: ALL stdAges: CHILD stdAges: ADULT stdAges: OLDER_ADULT hasResults: False
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<|newrecord|> nctId: NCT06302868 id: 006215 id: R43MH129065 type: NIH link: https://reporter.nih.gov/quickSearch/R43MH129065 briefTitle: Telemedicine-Based Virtual Reality Clinic for the Treatment of Phobias overallStatus: RECRUITING date: 2023-10-03 date: 2024-08-01 date: 2024-08-01 date: 2024-03-12 date: 2024-03-12 name: University of South Florida class: OTHER name: National Institute of Mental Health (NIMH) briefSummary: The purpose of this study is to assess the feasibility of conducting a randomized controlled efficacy trial comparing the delivery of exposure therapy via a telemedicine-based virtual reality clinic (Doxy.me VR) vs. standard telemental health (TMH) to adults with intense fear of dogs, snakes, and/or spiders. The secondary purpose is to preliminarily examine the efficacy of using Doxy.me VR vs. TMH in reducing phobia severity. conditions: Arachnophobia conditions: Cynophobia conditions: Ophidiophobia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: Telemedicine Exposure Therapy Using Photos and Videos name: Telemedicine-Based Virtual Reality Exposure Therapy measure: Phobia symptom severity sex: ALL minimumAge: 18 Years stdAges: ADULT stdAges: OLDER_ADULT facility: University of South Florida status: RECRUITING city: Tampa state: Florida zip: 33613 country: United States name: Brian Bunnell, PhD role: CONTACT name: Brian Bunnell, PhD role: PRINCIPAL_INVESTIGATOR name: Triton Ong, PhD role: PRINCIPAL_INVESTIGATOR lat: 27.94752 lon: -82.45843 typeAbbrev: Prot hasProtocol: True hasSap: False hasIcf: False label: Study Protocol date: 2023-11-21 uploadDate: 2024-01-23T13:01 filename: Prot_000.pdf size: 451422 typeAbbrev: ICF hasProtocol: False hasSap: False hasIcf: True label: Informed Consent Form date: 2023-12-11 uploadDate: 2024-01-23T12:22 filename: ICF_001.pdf size: 14053932 hasResults: False
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