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<|newrecord|> nctId: NCT06269705 id: 006-C-301 briefTitle: ZILRETTA in Subjects With Glenohumeral Osteoarthritis overallStatus: RECRUITING date: 2024-02-05 date: 2025-08 date: 2025-08 date: 2024-02-21 date: 2024-04-03 name: Pacira Pharmaceuticals, Inc class: INDUSTRY briefSummary: Primary Objective: To assess the effic... |
Secondary Objective: |
* To assess the efficacy of ZILRETTA on pain following an IA injection in subjects with glenohumeral OA relative to triamcinolone acetonide injectable suspension, immediate release (TCA-IR) and normal saline placebo |
* To assess the safety of ZILRETTA in subjects with glenohumeral OA relative to normal saline placebo and TCA-IR conditions: Glenohumeral Osteoarthritis studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: SINGLE maskingDescription: Only unblinde... |
<|newrecord|> nctId: NCT06269692 id: 2023-A01353-42 briefTitle: MAgnetic Resonance Imaging-guided implanTation of Cardioverter DEFibrillators acronym: SMART-DEF overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2030-04-01 date: 2030-04-01 date: 2024-02-21 date: 2024-02-21 name: Central Hospital, Nancy, France cl... |
Ventricular tachycardia (VT) and/or ventricular fibrillation (VF), which are responsible for most SCDs, result from the presence of surviving myocytes embedded within fibrotic MI-scar. The presence of these surviving myocytes, as well as their specific arrhythmic characteristics, is not captured by LVEF. Hence, the use... |
<|newrecord|> nctId: NCT06269679 id: RC23_0336 briefTitle: CBCT vs OPT on the Oral Health Status at 12 Months of Patients Hospitalized for Infective Endocarditis. acronym: 3D STARS overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2028-05-01 date: 2028-05-01 date: 2024-02-21 date: 2024-02-21 name: Nantes Univers... |
Thus, conducting a randomized controlled trial is highly desirable to assess the potential impact of a clinical examination/CBCT approach on the oral health status of patients hospitalized for IE and potentially to reduce IE new episodes. conditions: Infective Endocarditis studyType: INTERVENTIONAL phases: NA allocatio... |
<|newrecord|> nctId: NCT06269666 id: OPT1100 briefTitle: P200TxE Diseased Eye Image Collection overallStatus: RECRUITING date: 2024-01-31 date: 2024-06-30 date: 2024-06-30 date: 2024-02-21 date: 2024-02-21 name: Optos, PLC class: INDUSTRY briefSummary: The primary objective is to collect images on the P200TxE device in... |
<|newrecord|> nctId: NCT06269653 id: 10001944 id: 001944-AG briefTitle: Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide overallStatus: RECRUITING date: 2024-05-01 date: 2026-03-01 date: 2026-03-01 date: 2024-02-21 date: 2024-04-26 name: National Institute on Aging (NI... |
Proteins are essential to the health and structure of the cells that make up body tissues. Most proteins become damaged over time and are replaced with new ones. This process is called "protein turnover." Stress, disease, and aging can affect this process. Researchers want to better understand how aging affects protein... |
Objective: |
To measure rates of protein turnover in healthy adults. |
Eligibility: |
Healthy people aged 20 years and older with a body mass index between 20 and 30. |
Design: |
Participants will have 6 study visits over 4 to 6 weeks. They will fast 12 hours before each visit. |
Participants will be screened. They will have a physical exam, with blood and urine tests and tests of their heart function. They will lie down while blood pressure cuffs are used on their arms and legs. |
Participants will be given bottles of heavy water to drink at home on a schedule for 21 days. Each bottle holds about 3.5 tablespoons. Heavy water is odorless, colorless, and tasteless, like normal drinking water. It is safe to drink and has been used in research for many years. |
Participants will have tests during study visits, including: |
Imaging scans of a leg. |
Exercise on a treadmill. |
Biopsies of muscle, skin, and fat: Small samples of tissue will be cut from the calf and abdomen. |
Resting metabolic rate: Participants will lie still and breathe into a mask for 20 minutes. |
Knee/grip strength: Participants will do strength tests with their legs. They will squeeze a device with their hands. |
D3-Creatine: Participants will take 1 pill of D3-Creatine, which occurs naturally in muscle. conditions: Healthy Volunteers studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: CROSS_SECTIONAL count: 75 type: ESTIMATED measure: Measure the turnover proteins in humans across tissues, age, and sex. mea... |
<|newrecord|> nctId: NCT06269640 id: 10001640 id: 001640-H briefTitle: NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Early Feasibility Study overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-10-01 date: 2027-10-01 date: 2024-02-21 date: 2024-04-26 name: National Heart, Lung, and Blood Institute (N... |
Some people have a condition in which the wall (septum) that separates the two main pumping chambers of the heart is too thick. This thick septum causes a condition called "left ventricular outflow tract obstruction" (LVOTO), which reduces blood flow out of the heart. LVOTO can cause serious heart disease; symptoms may... |
Objective: |
To test a new procedure where excess tissue is sliced away from the septum in people with LVOTO. This procedure is called "septal scoring along midline endocardium" (SESAME). |
Eligibility: |
Adults aged 21 years with LVOTO. |
Design: |
Participants will have baseline tests. They will have imaging scans and tests of their heart structure and function. They will take a walking test and answer questions about how their heart condition affects their life. |
Participants will stay in the hospital 2 to 6 days for the SESAME procedure. |
They will be completely or partially asleep for the procedure. A tube will be inserted into the mouth and down the throat to take pictures of the heart. Pictures may also be taken with a tube inserted inside the heart. |
Next, tubes will be inserted into the groin and guided through the blood vessels up to the heart. Guidewires will be inserted into the heart. Doctors will watch the path the wires take with x-rays and ultrasound. When the wire is in the correct place, it will be electrified to slice excess tissue away from the septum. |
Participants will have 3 follow-up visits within 1 year. conditions: Hypertrophic Cardiomyopathy conditions: Left Ventricular Septal Hypertrophy conditions: Mitral Valve Disease conditions: Aortic Valve Stenosis studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: TREATMEN... |
<|newrecord|> nctId: NCT06269627 id: 10001644 id: 001644-AA briefTitle: Temporally-Resolved Electrophysiology of Acamprosate Treatment of Alcohol Use Disorder overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-31 date: 2026-12-31 date: 2024-02-21 date: 2024-04-26 name: National Institute on Alcohol Abuse ... |
Chronic heavy drinking can cause alcohol use disorder (AUD). AUD changes how the brain works. People with AUD may drink compulsively or feel like they cannot control their alcohol use. Acamprosate is an FDA-approved drug that reduces anxiety and craving in some, but not all, people with AUD. |
Objective: |
To learn more about how acamprosate affects brain function in people with AUD. |
Eligibility: |
People aged 21 to 65 years with moderate to severe AUD. |
Design: |
Participants will stay in the clinic for 21 days after a detoxification period of approximately 7 days. |
Acamprosate is a capsule taken by mouth. Half of participants will take this drug 3 times a day with meals. The other half will take a placebo. The placebo looks like the study drug but does not contain any medicine. Participants will not know which capsules they are taking. |
Participants will have a procedure called electroencephalography (EEG): A gel will be applied to certain locations on their scalp, and a snug cap will be placed on their head. The cap has sensors with wires. The sensors detect electrical activity in the brain. Participants will lie still and perform 2 tasks: they will ... |
Participants will have 2 EEGs: 1 on day 2 and 1 on day 23 of their study participation. They may opt to have up to 4 more EEG studies (one on day 13 and one on each of the three follow-up visits) and 2 sleep studies, in which they would have sensors attached to their scalp while they sleep. |
Participants may have up to three follow-up visits for 6 months. conditions: Alcohol Use Disorder studyType: INTERVENTIONAL phases: PHASE4 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: BASIC_SCIENCE masking: TRIPLE whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 4... |
<|newrecord|> nctId: NCT06269614 id: QOL334829 briefTitle: Assessing the Gut Microbiome and Its Association With Pediatric Stress and Cognition overallStatus: RECRUITING date: 2023-01-12 date: 2025-12-31 date: 2025-12-31 date: 2024-02-21 date: 2024-02-21 name: Nova Southeastern University class: OTHER briefSummary: Usi... |
<|newrecord|> nctId: NCT06269601 id: HÜ- FTR- BD- 02 briefTitle: The Reliability of the Upper Limb Rotation Test in Adolescent Male Basketball Players overallStatus: COMPLETED date: 2023-08-10 date: 2023-09-15 date: 2023-09-15 date: 2024-02-21 date: 2024-02-28 name: Hacettepe University class: OTHER briefSummary: The o... |
<|newrecord|> nctId: NCT06269588 id: NBM-NP004 briefTitle: Efficacy and Safety of Nexpowder™ for Non-variceal, Upper Gastrointestinal Bleeding overallStatus: RECRUITING date: 2024-02 date: 2024-12 date: 2024-12 date: 2024-02-21 date: 2024-02-21 name: Changi General Hospital class: OTHER name: Next Biomedical Co., Ltd. ... |
<|newrecord|> nctId: NCT06269575 id: Dysphagia briefTitle: Evaluation Of The Effectiveness Of Safe Nutrition Program Applied To Acute Stroke Patients With Dysphagia overallStatus: COMPLETED date: 2020-10-05 date: 2023-08-15 date: 2023-12-15 date: 2024-02-21 date: 2024-02-21 name: Istanbul University - Cerrahpasa (IUC) ... |
Question 1: Does a safe nutrition program prevent aspiration pneumonia, dehydration and malnutrition in acute stroke patients with dysphagia? Question 2: Is the safe nutrition program effective on addiction level, quality of life and depression in acute stroke patients with dysphagia? Question 3: Does a safe nutrition ... |
<|newrecord|> nctId: NCT06269562 id: clavicle briefTitle: SPSIPB and CPB on Clavicle Surgeries overallStatus: COMPLETED date: 2023-06-20 date: 2023-12-20 date: 2024-02-04 date: 2024-02-21 date: 2024-02-21 name: Cumhuriyet University class: OTHER briefSummary: Clavicular fractures represent a common occurrence often nec... |
<|newrecord|> nctId: NCT06269549 id: KDS_KOA briefTitle: Kinesiological / Dietary Supplement Intervention in Knee Osteoarthritis acronym: KDSKOA overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-09-30 date: 2025-12-31 date: 2024-02-21 date: 2024-02-26 name: University of Primorska class: OTHER name: Community ... |
* Is adding a dietary supplement to exercise additionally effective in managing KOA? |
* Is adding exercise to the dietary supplement additionally effective in managing KOA? |
Participants will be given in three groups: |
1. Real dietary supplement alone |
2. Real dietary supplement with exercise |
3. Placebo dietary supplement with exercise |
Investigators will compare groups 1 and 2, or 2 and 3, to answer the research questions. |
The hypothesis is that participants who receive the dietary supplement along with exercise will experience greater reduction in pain level, improved physical function, and enhanced quality of life compared to those who receive a placebo combined with exercise or dietary supplement alone. conditions: Osteoarthritis, Kne... |
<|newrecord|> nctId: NCT06269536 id: UC-SK004 briefTitle: Stress-reducing Intervention in Urothelial Carcinoma overallStatus: RECRUITING date: 2024-02-15 date: 2027-02-15 date: 2029-02-15 date: 2024-02-21 date: 2024-02-21 name: Comenius University class: OTHER briefSummary: The aim of this interventional study is to te... |
<|newrecord|> nctId: NCT06269523 id: MFR032024 briefTitle: Effects of Rehabilitation and Kinesio Taping to Prevent Axillary Web Syndrome After Breast Cancer Surgery overallStatus: COMPLETED date: 2021-07-21 date: 2023-01-31 date: 2024-01-31 date: 2024-02-21 date: 2024-02-21 name: University of Palermo class: OTHER brie... |
<|newrecord|> nctId: NCT06269510 id: HUM00242997 id: 1R01AA030748-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01AA030748-01 briefTitle: Enhancing Alcohol Treatment Engagement in Associated Liver Disease (ALD) Patients overallStatus: NOT_YET_RECRUITING date: 2025-04 date: 2027-07 date: 2027-07 date: 2024-0... |
<|newrecord|> nctId: NCT06269497 id: 2018/2300 briefTitle: TiO2-scaffolds for Alveolar Ridge Preservation acronym: TIOSCAFF overallStatus: COMPLETED date: 2021-11-09 date: 2022-06-20 date: 2023-08-10 date: 2024-02-21 date: 2024-02-21 name: University of Oslo class: OTHER briefSummary: The goal of this clinical trial is... |
<|newrecord|> nctId: NCT06269484 id: D4326C00004 briefTitle: A Phase IIb Study to Evaluate the Safety of Zibotentan/Dapagliflozin in Participants With Cirrhosis-ZEAL-UNLOCK acronym: ZEAL UNLOCK overallStatus: RECRUITING date: 2024-02-15 date: 2025-01-17 date: 2025-01-17 date: 2024-02-21 date: 2024-03-25 name: AstraZene... |
<|newrecord|> nctId: NCT06269471 id: 2023-A02039-36 briefTitle: On the ICC's Path: a Prevalence Study acronym: SSICC overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2024-05-30 date: 2024-07-30 date: 2024-02-21 date: 2024-02-21 name: University Hospital, Grenoble class: OTHER briefSummary: The number of trailer... |
However, there are no studies informing of the prevalence of chronic ankle instability in trail running. The aim of this study is therefore to take stock of chronic ankle instability in trail running in France. conditions: Chronic Ankle Instability studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RE... |
<|newrecord|> nctId: NCT06269458 id: ABU-001 briefTitle: The Effects of Mother-Baby Yoga and Baby Massage on Attachment and Sleep overallStatus: COMPLETED date: 2023-01-01 date: 2023-11-25 date: 2023-12-26 date: 2024-02-21 date: 2024-02-21 name: Antalya Bilim University class: OTHER briefSummary: Purpose: This study wa... |
Method: A randomised, crossover pilot study was conducted in the postpartum service of a hospital between January and November 2023, with 60 mothers and their babies in the postpartum period, 30 in each group. To the mothers and their babies included in the research, baby massage was applied to one group and mother-bab... |
<|newrecord|> nctId: NCT06269445 id: 2023-942-01 briefTitle: The Efficacy and Safety of Lcaritin Combined With Bevacizumab and FOLFIRI in Treatment of Liver Metastases From Colorectal Cancer overallStatus: RECRUITING date: 2024-01-01 date: 2025-02-01 date: 2026-02-01 date: 2024-02-21 date: 2024-02-21 name: Sir Run Run ... |
<|newrecord|> nctId: NCT06269432 id: 2023YFS0042 briefTitle: Precise Antiplatelet THerapy Guided by Platelet Aggregation Function in Acute Ischemic STROKE（PATH-STROKE） acronym: PATH-STROKE overallStatus: RECRUITING date: 2023-01-01 date: 2025-12-31 date: 2025-12-31 date: 2024-02-21 date: 2024-02-21 name: Sichuan Provin... |
<|newrecord|> nctId: NCT06269419 id: 2023-KY295 briefTitle: Study of Natural Course Progression of Diabetic Retinopathy overallStatus: RECRUITING date: 2024-02-25 date: 2029-01-01 date: 2029-01-01 date: 2024-02-21 date: 2024-03-12 name: Jie Li class: OTHER briefSummary: The goal of this observational study is to observ... |
Participants will have protocol-specific follow-up examinations at 1, 2, 3, 4, and 5 years (± 3 months). Additional visits are made as required by the study and the patient's condition. |
The contents of follow-up examinations are: |
History of other diseases, medications being used, eye diseases, surgeries, treatments, height, weight, and blood pressure. |
Best corrected vision, logarithmic visual acuity chart. Tupai OCTA, 24×20mm range, 6×6mm range scan. Optos fundus imaging, color and no red light images. Fundus fluorescence angiography (only preliminary examination for the first time found mild to moderate NPDR patients, who have been angiographed in the past, only at... |
Glycosylated hemoglobin. Creatinine, urea, glomerular filtration rate. Total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol. |
Urinary microalbumin/urinary creatinine ACR. Microvisual field. conditions: Biomarkers of Diabetic Retinopathy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 200 type: ESTIMATED measure: Observation and follow-up of biomarkers of diabetic retinopathy measure: Level of Glycosylat... |
<|newrecord|> nctId: NCT06269406 id: SW008 briefTitle: A Combination of Ibuprofen With Curcumin Covered With Liquorice Root Supplementation in the Management of Postoperative Dental Pain in Adults acronym: ICLID overallStatus: NOT_YET_RECRUITING date: 2024-03-10 date: 2024-07-10 date: 2024-09-10 date: 2024-02-21 date: ... |
<|newrecord|> nctId: NCT06269393 id: CIBI311Y101 briefTitle: A Study of IBI311 in Subjects With Steroid-resistant, Thyroid Associated Ophthalmopathy overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-01 date: 2025-06-01 date: 2026-02-01 date: 2024-02-21 date: 2024-02-21 name: Peking University People's Hospital class: ... |
<|newrecord|> nctId: NCT06269380 id: 30.01.2024-4274 briefTitle: Evaluation of Antral Biopsies Obtained in Normal Esophagogastroduodenoscopy overallStatus: COMPLETED date: 2024-02-13 date: 2024-02-20 date: 2024-02-21 date: 2024-02-21 date: 2024-02-23 name: Sisli Hamidiye Etfal Training and Research Hospital class: OTHE... |
In this study, a retrospective evaluation of the prevalence of various pathologies detected in biopsies obtained from endoscopically normal mucosa in patients who underwent EGD was reported as normal. conditions: Gastritis H Pylori conditions: Gastritis Chronic conditions: Intestinal Metaplasia studyType: INTERVENTIONA... |
<|newrecord|> nctId: NCT06269367 id: HUM00226149 id: 1R41HD111289-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R41HD111289-01 briefTitle: NewGait: A Low-Cost Rehabilitation System to Improve Post-Stroke Gait (Biomechanical Adaptations) overallStatus: RECRUITING date: 2024-04-01 date: 2024-12 date: 2024-12 d... |
<|newrecord|> nctId: NCT06269354 id: 20231121-71479 briefTitle: Multi-center Study on Comprehensive Diagnosis and Treatment of Lower Limb Bone Defect Based on Three-dimensional Printing Technology overallStatus: RECRUITING date: 2023-11-01 date: 2026-06-01 date: 2026-12-31 date: 2024-02-21 date: 2024-02-21 name: Peking... |
<|newrecord|> nctId: NCT06269341 id: SCCH-TS2208 briefTitle: Outcomes of Smoker and Drinker With Esophageal Squamous Cell Carcinoma After Esophagectomy acronym: OSinEC overallStatus: RECRUITING date: 2010-02-01 date: 2024-07-30 date: 2024-08-30 date: 2024-02-21 date: 2024-02-21 name: Sichuan Cancer Hospital and Researc... |
<|newrecord|> nctId: NCT06269328 id: 2011-KAEK-26/463 briefTitle: Measuring Sleep Quality In Patients That Posterior Spinal Instrumentatıon Plannıng overallStatus: COMPLETED date: 2022-07-01 date: 2023-09-01 date: 2024-01-01 date: 2024-02-21 date: 2024-02-28 name: Uludag University class: OTHER briefSummary: Postoperat... |
<|newrecord|> nctId: NCT06269315 id: SBDDCP briefTitle: Assessment of Skin Barrier Disruption Due to Daily Use of Cleaning Products and Hand Disinfectants acronym: SBDDCP overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-12-31 date: 2025-04-01 date: 2024-02-21 date: 2024-02-21 name: Swiss Institute of Aller... |
The main questions it aims to answer are: |
* How does exposure to household detergents and hand disinfectants impact skin barrier function? |
* Are there differences in skin barrier disruption between various types of cleaning agents and disinfectants? |
Participants will: |
Undergo patch testing with controlled amounts of household detergents and hand disinfectants on a small area of their skin. |
Be monitored for adverse reactions during and after exposure. Have their skin barrier integrity assessed using electrical impedance spectroscopy at multiple time points post-exposure. |
If there is a comparison group: |
Researchers will compare the effects of different types of cleaning agents, hand disinfectants, and their ingredients on skin barrier integrity to determine variations in their impact. conditions: Control Condition (PBS) conditions: Household Detergent Exposure conditions: Hand Disinfectant Exposure conditions: Surfact... |
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