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<|newrecord|> nctId: NCT06345677 id: ViXe-CLP-0002 briefTitle: Clinical Trial for the Assessment of Safety, Usability and Efficacy of the Vixe Combination for OAB in Female Subjects acronym: XAVIER overallStatus: COMPLETED date: 2023-06-09 date: 2024-02-01 date: 2024-02-01 date: 2024-04-03 date: 2024-04-09 name: Vensic... |
<|newrecord|> nctId: NCT06345664 id: 548/2022BO1 briefTitle: Interdisciplinary E-health Based Follow-up of Preterm Born Children acronym: NeoUp overallStatus: RECRUITING date: 2023-03-01 date: 2024-10 date: 2024-12 date: 2024-04-03 date: 2024-04-08 name: University Hospital Tuebingen class: OTHER briefSummary: The aim ... |
<|newrecord|> nctId: NCT06345651 id: 2023-03, Version 7 briefTitle: Brain Oscillation-synchronized Stimulation of the Frontal Cortex in Major Depressive Disorder acronym: BOSSFRONT2 overallStatus: RECRUITING date: 2023-09-01 date: 2025-08 date: 2025-08 date: 2024-04-03 date: 2024-04-03 name: University Hospital Tuebing... |
<|newrecord|> nctId: NCT06345638 id: 854343 briefTitle: Sex Hormones and Inflammatory Biomarkers in Patients With Sickle Cell Disease overallStatus: ENROLLING_BY_INVITATION date: 2024-03-01 date: 2025-04-30 date: 2025-05-31 date: 2024-04-03 date: 2024-04-03 name: University of Pennsylvania class: OTHER briefSummary: Th... |
* The study will compare CRP and other biomarkers between females with SCD in the follicular phase of the menstrual cycle and males with SCD. |
* The study will explore potential sex differences in biomarker changes between females and males with SCD during and following resolution of VOC. |
* The study will compare neutrophil and platelet adhesion to the endothelium and real time fibrin deposition in the blood. conditions: Sickle Cell Disease conditions: Vaso-occlusive Crisis studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 40 type: ESTIMATED measure: C-reactive prot... |
<|newrecord|> nctId: NCT06345625 id: 6012 briefTitle: Gait and Postural Balance Analysis During Head-motion Perturbed Standing and Walking in Older Adults acronym: BALANCAR overallStatus: RECRUITING date: 2024-04-15 date: 2027-01 date: 2028-01 date: 2024-04-03 date: 2024-04-16 name: Universiteit Antwerpen class: OTHER ... |
<|newrecord|> nctId: NCT06345612 id: Hypoxia-Exercise-DiabetesT1 briefTitle: Impact of Eccentric Training in Hypoxia With Creatine on Metabolic Control and VO2max in Patients With Type 1 Diabetes overallStatus: RECRUITING date: 2023-11-15 date: 2025-06 date: 2025-07 date: 2024-04-03 date: 2024-04-03 name: Silesian Cent... |
<|newrecord|> nctId: NCT06345599 id: LK2023100 briefTitle: PRaG Therapy in Combination With Locally Advanced Pancreatic Ductal Adenocarcinoma (PDAC) (NeoPRAG Study) overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2027-01-10 date: 2027-01-10 date: 2024-04-03 date: 2024-04-03 name: Second Affiliated Hospital of ... |
<|newrecord|> nctId: NCT06345586 id: 078066 briefTitle: Drospirenone Only Pills and Cervical Mucus Changes: A Pre- and Post-Bariatric Surgery Study overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-03 date: 2024-04-03 name: Chulalongkorn University class: OTHER briefSummary: The ... |
<|newrecord|> nctId: NCT06345573 id: BASEC 2020-02922 briefTitle: Heart-brain-axis and Psychosocial Stress overallStatus: ACTIVE_NOT_RECRUITING date: 2021-10-11 date: 2023-11-20 date: 2024-11 date: 2024-04-03 date: 2024-04-08 name: University of Zurich class: OTHER briefSummary: The main study objective is to prospecti... |
<|newrecord|> nctId: NCT06345560 id: 077766 briefTitle: Pharmacokinetics of Drospirenone Only Pills: A Pre- and Post-Bariatric Surgery Study overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-03 date: 2024-04-03 name: Chulalongkorn University class: OTHER briefSummary: The purpose... |
<|newrecord|> nctId: NCT06345547 id: EDGE 003539 briefTitle: Muscle Mass Via UltraSound in Cirrhosis (MMUSCLE) acronym: MMUSCLE overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2026-05-02 date: 2027-05-31 date: 2024-04-03 date: 2024-04-03 name: University Hospital, Antwerp class: OTHER briefSummary: The goal of... |
* what is the prevalence and development of sarcopenia in cirrhosis? |
* what is the role of malnutrition? Participants will |
* undergo a muscle ultrasound of the lower and upper limb muscles |
* handgrip strength will be measured |
* malnutrition screening and assessment |
* complete a questionnaire to assess quality of life conditions: Sarcopenia conditions: Cirrhosis conditions: Malnutrition studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 60 type: ESTIMATED name: ultrasound measure: Prevalence of sarcopenia: muscle mass measure: Prevalence of sar... |
<|newrecord|> nctId: NCT06345534 id: ONZ-2023-0255 briefTitle: FAST-FORWARD vs HAI5 overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2033-12-31 date: 2033-12-31 date: 2024-04-03 date: 2024-04-03 name: University Hospital, Ghent class: OTHER briefSummary: Randomized comparison between the FAST-FORWARD schedule and ... |
<|newrecord|> nctId: NCT06345521 id: 2022-1-4032-3 briefTitle: The Follow-up System of Pediatric Heart Failure and the Establishment of End-stage Heart Failure Registry overallStatus: RECRUITING date: 2022-01-01 date: 2024-06-22 date: 2024-12-31 date: 2024-04-03 date: 2024-04-03 name: China National Center for Cardiova... |
<|newrecord|> nctId: NCT06345508 id: 2024-12161 briefTitle: Early Detection of Liver Cancer by QUS acronym: QUS in HCC overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2029-06 date: 2029-12 date: 2024-04-03 date: 2024-04-12 name: Centre hospitalier de l'Université de Montréal (CHUM) class: OTHER name: Centre de Re... |
<|newrecord|> nctId: NCT06345495 id: 2023-0899 id: NCI-2024-02814 type: OTHER domain: NCI-CTRP Clinical Registry briefTitle: High Dose Ruxolitinib and Allogeneic Stem Cell Transplantation in Myelofibrosis Patients With Splenomegaly overallStatus: NOT_YET_RECRUITING date: 2024-09-30 date: 2027-01-01 date: 2029-01-01 dat... |
<|newrecord|> nctId: NCT06345482 id: MHB039A-A-101 briefTitle: A Study of MHB039A for Advanced Solid Tumor overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2028-04-01 date: 2029-06-01 date: 2024-04-03 date: 2024-04-03 name: Minghui Pharmaceutical (Hangzhou) Ltd class: INDUSTRY briefSummary: Phase I/II open labe... |
<|newrecord|> nctId: NCT06345469 id: O-PBM2 briefTitle: Cost Analysis of Therapies for Severe Anemia overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-04-01 date: 2026-05-01 date: 2024-04-03 date: 2024-04-03 name: Helios Klinik Gotha/Ohrdruf class: OTHER name: Marisa Eichner briefSummary: The goal of this o... |
The main question the study aims to answer is: Do participants treated with transfusions incur the same treatment costs than participants treated with PBM? And how much costs are this in relation to the lives saved by the therapy of severe anemia? conditions: Severe Anemia studyType: OBSERVATIONAL observationalModel: C... |
<|newrecord|> nctId: NCT06345456 id: izmirkatip briefTitle: The Value of End-tidal Capnography in Gastrointestinal Bleeding overallStatus: COMPLETED date: 2020-06-01 date: 2021-01-01 date: 2021-01-01 date: 2024-04-03 date: 2024-04-08 name: Izmir Katip Celebi University class: OTHER briefSummary: Gastrointestinal bleedi... |
In our study, the investigators aimed to determine the severity of gastrointestinal bleeding by using the Glaskow Blachford Score and AIMS65 score in cases presenting with gastrointestinal bleeding, to determine the end tidal carbon dioxide value by capnography in these cases and to determine its effectiveness in evalu... |
<|newrecord|> nctId: NCT06345443 id: 23-005288 briefTitle: NRM on Vascular Perfusion in Heathy Adults acronym: NRM overallStatus: NOT_YET_RECRUITING date: 2024-05-15 date: 2025-12-31 date: 2026-05-31 date: 2024-04-03 date: 2024-04-03 name: Mayo Clinic class: OTHER briefSummary: The purpose of this study is to better un... |
<|newrecord|> nctId: NCT06345430 id: 2023-14 briefTitle: Wearable Technological Device Applied to Patients With Chronic Pain overallStatus: COMPLETED date: 2023-11-18 date: 2024-01-15 date: 2024-01-30 date: 2024-04-03 date: 2024-04-03 name: Hacettepe University class: OTHER briefSummary: Within the scope of this resear... |
<|newrecord|> nctId: NCT06345417 id: O-PBM1 briefTitle: Outcomes of Patient Blood Management in Severely Anemic Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-04-01 date: 2025-05-01 date: 2024-04-03 date: 2024-04-03 name: Helios Klinik Gotha/Ohrdruf class: OTHER name: Helios Klinikum Erfurt brie... |
* Which group of patients dies more frequent: Patients who receive patient blood management only, patients who receive patient blood management and transfusions or patients who receive only transfusions? |
* Among these groups: which group of patients has more complications during hospital stay? Patients will either receive patient blood management, which is the management of anemia, bleeding and coagulation problems, will receive transfusions, that is, blood from other people, or a mix of both. conditions: Severe Anemia... |
<|newrecord|> nctId: NCT06345404 id: CPI-818-003 briefTitle: Safety, Tolerability, and Preliminary Efficacy of Soquelitinib in Participants With Moderate to Severe AD overallStatus: RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-03 date: 2024-04-10 name: Corvus Pharmaceuticals, Inc. class: INDUSTRY ... |
<|newrecord|> nctId: NCT06345391 id: PANACEA_CO-CREATION_2024 briefTitle: Co-creation of Pain Science Education for Children Living Beyond Cancer acronym: PANACEA overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-09 date: 2024-09 date: 2024-04-03 date: 2024-04-03 name: Vrije Universiteit Brussel class: OTHER n... |
<|newrecord|> nctId: NCT06345378 id: IRFMN_PapaGio briefTitle: Evaluation of the Quality of Care in the Emergency Department by Studying the Appropriateness of Admissions of Patients Accessing the Emergency Department (ASST Papa Giovanni XXIII) overallStatus: ACTIVE_NOT_RECRUITING date: 2021-11-25 date: 2024-12 date: 2... |
<|newrecord|> nctId: NCT06345365 id: 09 briefTitle: MA+AZA Regimen for the Treatment of Newly Diagnosed Acute Myeloid Leukemia (AML) overallStatus: RECRUITING date: 2024-01-18 date: 2026-12-31 date: 2028-12-31 date: 2024-04-03 date: 2024-04-10 name: Zhongnan Hospital class: OTHER name: Ruijin Hospital name: Shanxi Prov... |
<|newrecord|> nctId: NCT06345352 id: IRFMN_7520_PoliMI briefTitle: Evaluation of the Quality of Care in the Emergency Department by Studying the Appropriateness of Admissions of Patients Accessing the Emergency Department (Fondazione IRCCS Ca' Granda Ospedale Maggione Policlinico) overallStatus: ACTIVE_NOT_RECRUITING d... |
<|newrecord|> nctId: NCT06345339 id: M21-341 briefTitle: A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants overallStatus: RECRUITING date: 2024-04-26 date: 2028-06-03 date: 2028-06-03 date: 2024-04-03 date: 2024-04... |
<|newrecord|> nctId: NCT06345326 id: E1-22-3155 briefTitle: Greater Occipital Nerve Block Versus Pulse Radiofrequency in Migraine acronym: GON-B/PRF overallStatus: RECRUITING date: 2023-01-15 date: 2024-03-30 date: 2024-04-30 date: 2024-04-03 date: 2024-04-03 name: Adiyaman University Research Hospital class: OTHER nam... |
<|newrecord|> nctId: NCT06345313 id: CIRCADIAN RHYTHM briefTitle: EFFECT OF CIRCADIAN RHYTHM ON INFLAMMATORY PARAMETERS IN UNILATERAL INGUINAL HERNIORRAHIES overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-09-15 date: 2024-10-15 date: 2024-04-03 date: 2024-04-03 name: Ankara City Hospital Bilkent class: OT... |
<|newrecord|> nctId: NCT06345300 id: NCC4309 briefTitle: NALIRIFOX in Combination With Camrelizumab for BRPC: a Prospective, Exploratory Study overallStatus: RECRUITING date: 2024-03-10 date: 2024-12-12 date: 2025-12-24 date: 2024-04-03 date: 2024-04-03 name: Cancer Institute and Hospital, Chinese Academy of Medical Sc... |
<|newrecord|> nctId: NCT06345287 id: 24/018-4298 briefTitle: Response Adaptive Radiotherapy Following Immunotherapy-based Induction for Non-HPV Related HNSCC overallStatus: RECRUITING date: 2024-01-01 date: 2025-12-31 date: 2026-12-31 date: 2024-04-03 date: 2024-04-03 name: Cancer Institute and Hospital, Chinese Academ... |
<|newrecord|> nctId: NCT06345274 id: SP0077172 id: K23DA050729 type: NIH link: https://reporter.nih.gov/quickSearch/K23DA050729 briefTitle: MBC2OTP Project (Measurement-Based Care Implementation in Community Opioid Treatment Programs) acronym: MBC2OTP overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2026-02 date: ... |
<|newrecord|> nctId: NCT06345261 id: 2024-872 briefTitle: Diphenhydramine in Catheter Related Bladder Discomfort overallStatus: ENROLLING_BY_INVITATION date: 2024-04-01 date: 2025-04-01 date: 2025-05-01 date: 2024-04-03 date: 2024-04-03 name: Cairo University class: OTHER briefSummary: Diphenhydramine has H1-antihistam... |
<|newrecord|> nctId: NCT06345248 id: 2024-854 briefTitle: Laparoscopic-assisted Versus Ultrasonography-guided Transversus Abdominis Plane Block in Laparoscopic Sleeve Gastrectomy overallStatus: ENROLLING_BY_INVITATION date: 2024-04-01 date: 2025-04-01 date: 2025-05-01 date: 2024-04-03 date: 2024-04-03 name: Cairo Unive... |
<|newrecord|> nctId: NCT06345235 id: ID DEC-2023/07/X/NZ5/00141 briefTitle: New Biomarkers and Plasma Prothrombotic Potential in Cardiac Transthyretin Amyloidosis overallStatus: RECRUITING date: 2023-07-11 date: 2024-07-11 date: 2024-07-11 date: 2024-04-03 date: 2024-04-19 name: John Paul II Hospital, Krakow class: OTH... |
Purpose of the study: To assess the diagnostic value of biomarkers related to heart failure (growth differentiation factor-15 (GDF15), soluble suppression of tumorigenicity-2 (ST2), galectin-3), amyloidosis ( TTR, tissue inhibitor of metalloproteinase-1 (TIMP-1), matrix metalloproteinase-9 (MMP-9, matrix metalloprotein... |
Methods: This prospective, single-center study will include consecutive patients diagnosed with ATTR cardiomyopathy (GROUP 1, n=30), asymptomatic carriers of pathogenic TTR variants (GROUP 2, n=30), and a matched control group of healthy volunteers (GROUP 3 , n=20). Material for research was collected and secured from ... |
<|newrecord|> nctId: NCT06345222 id: GETAT 23/05 briefTitle: Examining the Effect of Prolotherapy on Quality of Life and Painkiller Use in Patients With Knee Pain overallStatus: COMPLETED date: 2023-05-01 date: 2023-07-31 date: 2023-07-31 date: 2024-04-03 date: 2024-04-04 name: Bursa Yüksek İhtisas Education and Resear... |
<|newrecord|> nctId: NCT06345209 id: BM-D19 briefTitle: Efficacy and Safety of Sirolimus-coated Coronary Balloon Dilatation Catheter for Coronary Small Vessels overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-12 date: 2025-12 date: 2024-04-03 date: 2024-04-03 name: BrosMed Medical Co., Ltd class: INDUSTRY nam... |
<|newrecord|> nctId: NCT06345196 id: BozokUni briefTitle: Motivational Interviewing Applied to Individuals With Diabetes overallStatus: RECRUITING date: 2024-04-15 date: 2024-05-15 date: 2024-10-15 date: 2024-04-03 date: 2024-04-03 name: Bozok University class: OTHER briefSummary: This study will be conducted using a r... |
<|newrecord|> nctId: NCT06345183 id: CA209-1275 briefTitle: Real-World Outcomes of Nivolumab+Ipilimumab and Pembrolizumab+Lenvatinib Among US Advanced Renal Cell Carcinoma (aRCC) Patients overallStatus: RECRUITING date: 2024-02-19 date: 2024-04-01 date: 2024-12-31 date: 2024-04-03 date: 2024-04-03 name: Bristol-Myers S... |
<|newrecord|> nctId: NCT06345170 id: buhucgun05 briefTitle: Investigation the Effect of the Social-Communication Area Developmental Screening Test for Infants and Young Children Training Program Applied in Addition to the DIR/Floortime™ Therapy Program in Children With Developmental Risk overallStatus: RECRUITING date:... |
<|newrecord|> nctId: NCT06345157 id: COMB157GIT02 briefTitle: ITAKOS - Italian Observation, Multicenter, Prospective Study of Ofatumumab in RRMS Patients overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2026-04-30 date: 2026-04-30 date: 2024-04-03 date: 2024-04-03 name: Novartis Pharmaceuticals class: INDUSTRY ... |
<|newrecord|> nctId: NCT06345144 id: 202307211RINC briefTitle: Learning Experience of Undergraduate Nursing Students in Pediatric Oncology Ward overallStatus: RECRUITING date: 2023-08-22 date: 2024-03-29 date: 2024-03-29 date: 2024-04-03 date: 2024-04-03 name: National Taiwan University Hospital class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06345131 id: KY20230829-06 briefTitle: Clinical Research Plan for the Safety and Accuracy of Ultrasound-guided Radial Artery Puncture Catheterization overallStatus: RECRUITING date: 2023-07-01 date: 2024-08 date: 2024-09 date: 2024-04-03 date: 2024-04-03 name: Nanjing First Hospital, Nanjing Med... |
<|newrecord|> nctId: NCT06345118 id: FallpreventT2DMelderly briefTitle: Evaluate the Results of Fall Prevention in Older Adults With Type 2 Diabetes Mellitus acronym: FallT2DMOLD overallStatus: RECRUITING date: 2024-03-01 date: 2024-09-01 date: 2025-12-31 date: 2024-04-03 date: 2024-04-03 name: National Geriatric Hospi... |
* Describe the current situation of falls, the risk of falls, and some related factors in elderly type 2 diabetic patients |
* Evaluate the results of fall prevention and related factors in the study population. |
Participants will be randomly divided into control and intervention groups. The intervention group will be trained to follow the Otago Training Program as the primary fall prevention method. On the other hand, the control group will receive the standard care following the treatment guidelines for type 2 diabetes mellit... |
At the end of the intervention, the study will mainly compare the rate of fall incidents after 6 months of intervention as well as other physical performance tests. conditions: Diabetes Mellitus, Type 2 conditions: Fall conditions: Elderly Patient studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED intervention... |
<|newrecord|> nctId: NCT06345105 id: AIeffectiveV4 briefTitle: Real Time Effective Withdrawal Time and Adenoma Detection Rate overallStatus: RECRUITING date: 2024-04-01 date: 2024-11-30 date: 2025-01-31 date: 2024-04-03 date: 2024-04-16 name: The University of Hong Kong class: OTHER briefSummary: The goal of this obser... |
<|newrecord|> nctId: NCT06345092 id: Omfs.3-3-3 briefTitle: Comparison Between IPRF With Vit. C and IPRF Alone in Management of ID'Pain overallStatus: COMPLETED date: 2022-09-01 date: 2023-03-01 date: 2023-09-01 date: 2024-04-03 date: 2024-04-04 name: Cairo University class: OTHER briefSummary: Randomized clinical tria... |
<|newrecord|> nctId: NCT06345079 id: AG0219NET briefTitle: Cessation of Somatostatin Analogues After PRRT in Mid-Gut Neuroendocrine Tumours acronym: STOPNET overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2027-09 date: 2028-06 date: 2024-04-03 date: 2024-04-03 name: Australasian Gastro-Intestinal Trials Group cla... |
The aim of this study is to estimate the outcomes of patients with grade 1 and 2 well differentiated mid and hind-gut neuroendocrine tumours who have progressed on SSA therapy and receive subsequent PRRT with or without concurrent SSA. conditions: Neuroendocrine Tumors studyType: INTERVENTIONAL phases: PHASE2 allocatio... |
<|newrecord|> nctId: NCT06345066 id: 18834 id: J3R-MC-YDAC type: OTHER domain: Eli Lilly And Company briefTitle: A Study of LY3841136 in Overweight and Obese Participants overallStatus: RECRUITING date: 2024-04-03 date: 2025-03 date: 2025-03 date: 2024-04-03 date: 2024-04-19 name: Eli Lilly and Company class: INDUSTRY ... |
<|newrecord|> nctId: NCT06345053 id: 203428 briefTitle: Presence of PTSD and Emotion Dysregulation Among Inpatients With Substance Use Disorder overallStatus: RECRUITING date: 2021-05-01 date: 2024-10-01 date: 2025-10-01 date: 2024-04-03 date: 2024-04-03 name: Norwegian University of Science and Technology class: OTHER... |
This project can increase knowledge about psychological mechanisms in co-occurring PTSD and SUD and improve the quality of treatment for this vulnerable patient population. conditions: Post Traumatic Stress Disorder conditions: Substance Use Disorders conditions: Emotion Regulation conditions: Suicide conditions: Self-... |
<|newrecord|> nctId: NCT06345040 id: H-22067692 briefTitle: The Dialogue Study: A Virtual-reality Based Treatment for Eating Disorders overallStatus: RECRUITING date: 2024-02-26 date: 2025-12 date: 2026-06 date: 2024-04-03 date: 2024-04-03 name: Mental Health Services in the Capital Region, Denmark class: OTHER briefSu... |
<|newrecord|> nctId: NCT06345027 id: H-53163 CASEY briefTitle: CHIMERIC ANTIGEN RECEPTOR TREATMENT TARGETING CD70 (SEVENTY) acronym: CASEY overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2026-05-01 date: 2042-04-01 date: 2024-04-03 date: 2024-04-03 name: Baylor College of Medicine class: OTHER briefSummary: Th... |
Some patients with Lymphoma or T/NK-lymphoproliferative disease show signs of virus that is sometimes called Epstein Barr virus (EBV). This virus causes mononucleosis or glandular fever ("mono") before or at the time of their diagnosis. EBV is found in the cancer cells of up to half the patients with Hodgkin's and non-... |
T cells, also called T lymphocytes, are special infection-fighting blood cells that can kill other cells, including cells infected with viruses and tumor cells. T cells have been used to treat patients with cancers. T cells, that have been trained to kill EBV infected cells can survive in blood and affect the tumor. We... |
We think that if T cells are able to last longer in the body, they may have a better chance of killing EBV and EBV infected tumor cells. Therefore, in this study we will add a new gene to the EBV T cells that can cause the cells to live longer called C7R. We know that T cells need substances called cytokines (substance... |
The purpose of this study is to find the largest safe dose of C7R-EBV T cells, and additionally to evaluate how long they can be detected in the blood and what affect they have on the cancer. conditions: Leukemia, Myeloid, Acute conditions: Leukemia, B-cell conditions: Leukemia, T-Cell conditions: Lymphoma studyType: I... |
<|newrecord|> nctId: NCT06345014 id: 23CP40803 briefTitle: The Efficacy and Safety of OM-89 in Patients With Recurrent Chronic Prostatitis/Chronic Pelvic Pain Syndrome overallStatus: RECRUITING date: 2023-12-20 date: 2025-12-30 date: 2026-03-30 date: 2024-04-03 date: 2024-04-04 name: AJU Pharm Co., Ltd. class: INDUSTRY... |
In parallel, an alpha blocker (alfuzosin 10 mg) will be administered for the first 13 weeks as a background treatment, followed by the placebo of alfuzosin until Week 26. The efficacy and safety will be checked until Week 52 from the start of the treatment for all subjects. primaryPurpose: TREATMENT masking: QUADRUPLE ... |
After week 13, Background treatment will be blinded for subject only until end of treatment period(Week 26). whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 332 type: ESTIMATED name: OM-89 [Uro-Vaxom® Capsule] name: OM-89 Placebo [Uro-Vaxom® Capsule Placebo] m... |
<|newrecord|> nctId: NCT06345001 id: 22261 briefTitle: A First-in-Human Study to Learn About How BAY3630942 is Distributed and Processed Inside the Body When Given After BAY3547922 and How Safe it is in People With Liver Cancer overallStatus: NOT_YET_RECRUITING date: 2024-04-30 date: 2024-08-12 date: 2024-08-30 date: 2... |
To do this, researchers have developed a protein, called a monoclonal antibody, which can find and attach itself to another protein present on the surface of liver cancer cells. This can help the new treatment to specifically target cancer cells in the liver. |
In this study, researchers want to understand the distribution and processing of this monoclonal antibody in people with liver cancer. |
Researchers will use the following two forms of monoclonal antibody as study interventions during this study: |
* BAY3630942: This is the monoclonal antibody attached to a tracer. A tracer emits radiation that can help researchers track the monoclonal antibody in the body using imaging tests like PET/CT (positron emission tomography / computed tomography). All participants will receive a fixed dose of BAY3630942 during the study... |
* BAY3547922: This is the monoclonal antibody without the tracer. Participants may receive different amounts of BAY3547922 during the study. |
In this study, participants will not derive therapeutic benefit from receiving BAY3630942 or BAY3547922. However, this study may help researchers develop a new treatment for people with liver cancer and find a dose to be tested in future studies. |
The main purpose of this first-in-human study is to check how BAY3630942 distributes among different organs in the body and how much of the radiation it emits is absorbed by the organs based on the total dose of BAY3630942 and BAY3547922 given. For this, the researchers will: |
* measure the amount of BAY3630942 radiation found in different organs over time. |
* measure the amount of BAY3630942 radiation absorbed by different organs. |
* use the above information to estimate the amount of radiation that would be absorbed by the same organs from the new potential treatment. |
Researchers will also monitor the number and severity of medical problems participants have after receiving BAY3630942 and BAY3547922. These medical problems are also known as "adverse events". Doctors keep track of all medical problems that happen in studies, even if they do not think they might be related to the stud... |
The study participants will first receive BAY3547922 as an infusion into a vein followed by BAY3630942 as an injection into the same vein. Both interventions will be administered only once, on the same day. |
Each participant will be in the study for around 44 days with up to 7 visits to the study clinic which includes: |
* a visit up to 14 days before the start of the study to confirm if the participant can take part in the study. |
* up to 5 visits during the imaging intervention period. During this period, participants: |
* will receive the study interventions and have blood tests on the first visit, |
* will have imaging and blood tests on the next 3 visits. The tests scheduled for the second visit may be performed during the first visit. |
* may have blood tests on the last visit. |
* a follow-up visit to check their health after 30 days of receiving the study interventions. |
During the study, the doctors and their study team will: |
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