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Before the start of the treatment, at the end of the 3rd week and at the end of the 6th week; pain intensity, level of neck disability, quality of life, cervical range of motion and cervical joint position sense will be evaluated and both groups will be compared in these parameters. |
Demographic information (address, telephone, age, occupation, height, weight, marital status, etc.) of the patients to be included in the study will be recorded and general musculoskeletal examinations will be performed. The patients will be compared to evaluate for Visual Analogue Scale (VAS), Neck Disability Index (N... |
<|newrecord|> nctId: NCT06337903 id: Self-compassion for PwMS briefTitle: Self-compassion for People With Multiple Sclerosis: An Exploratory Feasibility Study overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-30 date: 2025-04-30 date: 2024-03-29 date: 2024-04-01 name: Robert Simpson class: OTHER briefSum... |
1. Explore feasibility of trial processes including recruitment, adherence, retention, and follow-up |
2. Explore experiences of people with multiple sclerosis with the Compassion-based intervention, including perceived effects, barriers and facilitators to participation, suggestions for improvement |
3. Determine potential effects on stress, anxiety, depression, emotion regulation, illness adjustment, and self-compassion. |
Participants will be asked to take part in an 8-week online Mindful Self-Compassion course and report changes in levels of stress, anxiety, depression, self-compassion, adjustment, emotion, and quality of life from pre- to post-intervention and at 3-month follow-up. Additionally, participants will be asked to take part... |
<|newrecord|> nctId: NCT06337890 id: FEZECO briefTitle: CO2 Automated Angiographies With Fusion Imaging for Zero- or Near Zero- Contrast FEVAR. overallStatus: RECRUITING date: 2024-01-01 date: 2024-12-31 date: 2024-12-31 date: 2024-03-29 date: 2024-03-29 name: University of Bologna class: OTHER briefSummary: Fenestrate... |
Postoperative renal function worsening is a common adverse event after FEVAR of complex aneurysms and is associated with prolonged hospital stay, higher morbidity, and long-term mortality in the peri-operative period and during follow-up. One of the more common causes of renal function worsening is contrast-induced nep... |
Automated carbon dioxide (CO2) angiography has been proposed as an alternative to ICM for standard endovascular aneurysm repair (EVAR) in consideration of its absence of nephrotoxicity that can be of further help in preserving renal function. |
In adjunct, hybrid room and fusion imaging (FI) technologies are useful tools to reduce intraoperative contrast medium and fluoroscopy time. |
In literature there are few reports regarding the use of CO2 for fenestrated endografting repair of complex aortic aneurysms. |
The aim of the present study is to report the possibility to combine the use of automated CO2 angiographies and Fusion Imaging to obtain zero- or near zero- contrast FEVAR for complex aortic aneurysms. conditions: Aortic Aneurysm studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE cou... |
<|newrecord|> nctId: NCT06337877 id: pEEG ARDS briefTitle: Assessment of Sedation Depth in ARDS Patients Undergoing Therapeutic Paralysis overallStatus: ACTIVE_NOT_RECRUITING date: 2023-10-01 date: 2024-04-17 date: 2024-04-24 date: 2024-03-29 date: 2024-03-29 name: Tepecik Training and Research Hospital class: OTHER br... |
<|newrecord|> nctId: NCT06337864 id: H-24017055 briefTitle: Evaluating the Efficacy and Safety of Large Neutral Amino Acids in the Treatment of Classical Phenylketonuria overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-12 date: 2027-12 date: 2024-03-29 date: 2024-03-29 name: Rigshospitalet, Denmark class: OTH... |
1. A crossover study comparing LNAA supplementation to no treatment |
2. A crossover study comparing LNAA supplementation to the Phe-free PKU diet |
3. Open-label extension study to assess the long-term safety and efficacy of LNAA supplementation |
4. Healthy control group primaryPurpose: TREATMENT masking: NONE count: 30 type: ESTIMATED name: PreKUnil® LNAA Medical Food for PKU measure: Dynamic positron emission tomography (PET) imaging with the fluorine-18-labeled tracer [18F]-(E)-N-(3-iodoprop-2-enyl)-2β-carbofluoroethoxy-3β-(4'-methyl phenyl)nortropane ([18F]... |
<|newrecord|> nctId: NCT06337851 id: AtaturkTRH2003/9 briefTitle: Comparing Simultaneous and Consecutive Drainage of Bilateral Chronic Subdural Hematoma overallStatus: COMPLETED date: 2003-11 date: 2010-04 date: 2011-04 date: 2024-03-29 date: 2024-03-29 name: Ataturk Training and Research Hospital class: OTHER briefSum... |
In previous reports, bilateral CSDH was raised as a predictor of rapid deterioration and worse outcomes attributable to brain herniation, in comparison with unilateral ones. Nevertheless, the optimal surgical considerations in bilateral CSDH still remain controversial. Thus, this study principally aims to finding out w... |
Inclusion criteria Symptomatic adult (≥18 years-old) patients with bilateral hemispheric CSDH |
Exclusion criteria Patients with hematoma thickness smaller than 10 mm on either side, and those who previously underwent any cranial surgery |
Randomization Simple randomization, without blocking, will be used to divide patients into two groups simultaneous burr hole craniostomy (Group-1) and consecutive burr hole craniostomy (Group-2). |
Clinical Evaluation Neurological examination and scoring systems (Glasgow coma scale and Markwalder Grading) will be used. |
Radiological Evaluation Radiological evaluations will be made with CT and MR imaging. |
Operation Patients in group-1 were fixed in supine position with their heads in neutral and flexion position. Bilateral burr holes were made one after another, the dural surfaces were exposed at the same time, then the outer membranes of both sides opened and hematomas evacuated simultaneously. All the patients underwe... |
Follow-Up Depending on the subdural fluid collected, all drains will be removed within post-operative 36-48 hours. |
Only the patients with epileptic history and on epileptic medication will receive postoperative antiepileptics. |
In the postoperative period, a comprehensive evaluation encompassing neurological examinations and CT imaging will be performed. |
This evaluation protocol will be executed immediately following the surgical procedure, after the removal of surgical drains (usually on the second postoperative day), and at designated intervals of the 1st, 3rd, 6th, and 12th months to monitor patient progress and recovery. conditions: Subdural Hematoma, Chronic study... |
<|newrecord|> nctId: NCT06337838 id: 2024.BRACKETS-Pilot briefTitle: Bleeding Reduction in Acute and Chronic Kidney Patients Having Surgery (BRACKETS) Pilot Trial acronym: BRACKETS overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-12 date: 2026-03 date: 2024-03-29 date: 2024-03-29 name: Population Health Resea... |
<|newrecord|> nctId: NCT06337825 id: 22-727 briefTitle: Object Assessment of Improvement in Non-Specific Symptoms After Parathyroidectomy for Primary Hyperparathyroidism overallStatus: ACTIVE_NOT_RECRUITING date: 2022-07-19 date: 2024-03-12 date: 2024-06-29 date: 2024-03-29 date: 2024-04-15 name: The Cleveland Clinic c... |
<|newrecord|> nctId: NCT06337812 id: HUM00240473 briefTitle: Fiber Supplementation in Heart Failure With Preserved Ejection Fraction (HFpEF) overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-06 date: 2025-06 date: 2024-03-29 date: 2024-03-29 name: University of Michigan class: OTHER briefSummary: The study tea... |
<|newrecord|> nctId: NCT06337799 id: 202210411 briefTitle: Use of Allied-health Professionals to Improve Treatment of Disease overallStatus: NOT_YET_RECRUITING date: 2026-10 date: 2030-03 date: 2030-03 date: 2024-03-29 date: 2024-03-29 name: University of Iowa class: OTHER briefSummary: The goal of this clinical trial ... |
Participants will: |
Take their blood pressure at home and return it to the research team; Follow up with a research pharmacist for 12 months; Return for a follow up visit after 12 months. conditions: Preeclampsia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP primaryPurpose: PREVENTION masking: NONE co... |
<|newrecord|> nctId: NCT06337786 id: MSK-2023-TSJ1 briefTitle: Investigating the Effects of the Digital App Rheumabuddy4.1 in a Clinical Set-up in Patients With Rheumatoid Arthritis overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-01 date: 2025-01 date: 2024-03-29 date: 2024-04-05 name: Henning Bliddal class:... |
There is a discrepancy in the understanding of what's of importance when living a life with a chronic disease. |
The importance of patients' perspectives concerning disease- and treatment related impacts, is of crucial importance when involving patients in decisions about treatment, and to support the patients in optimal medication-taking behaviour to ensure patient health and reduce health care costs. There are still unmet needs... |
The aim of this study is to investigate and evaluate the effects of the digital app RheumaBuddy4.1 (RB4.1) and the ability to provide support and increase quality of life in patients with RA conditions: Rheumatoid Arthritis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interven... |
The number of study participants is 40 in the intervention arm and up to 120 in the matched control arm. primaryPurpose: OTHER masking: NONE count: 160 type: ESTIMATED name: Digital app RB4.1 name: Control arm measure: Primary Outcome measure: Disease-activity Score28 using C-reactive protein (DAS28-CRP) measure: Self-... |
<|newrecord|> nctId: NCT06337773 id: B-BR-112-036 briefTitle: Developing the Precision Nursing Education Program to Young Colorectal Cancer Survivors overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2024-09-30 date: 2026-12-25 date: 2024-03-29 date: 2024-03-29 name: Fooyin University class: OTHER briefSummary: ... |
<|newrecord|> nctId: NCT06337760 id: IEO 1669 briefTitle: YOUNg Adults With Gastro-inteSTinal (GI) and nEuroendocrine canceRs. acronym: YOUNGSTER overallStatus: RECRUITING date: 2023-03-10 date: 2026-12-31 date: 2027-06-30 date: 2024-03-29 date: 2024-03-29 name: European Institute of Oncology class: OTHER briefSummary:... |
<|newrecord|> nctId: NCT06337747 id: 04-2023-PLLA briefTitle: Comparing Injections With Poly-L-Lactic Acid in the Temporal Fossa vs. Extended Temporal Fossa + Hairline overallStatus: RECRUITING date: 2023-05-19 date: 2024-04-30 date: 2024-06 date: 2024-03-29 date: 2024-03-29 name: Erevna Innovations Inc. class: OTHER b... |
<|newrecord|> nctId: NCT06337734 id: 2 briefTitle: An Artificial Intelligence-Assisted Digital Health Lifestyle Intervention for Adults With Hypertension overallStatus: COMPLETED date: 2021-11-01 date: 2023-08-01 date: 2023-08-01 date: 2024-03-29 date: 2024-04-01 name: University of California, San Diego class: OTHER b... |
<|newrecord|> nctId: NCT06337721 id: R01AA030786 type: NIH link: https://reporter.nih.gov/quickSearch/R01AA030786 briefTitle: Preventing Alcohol Use Disorders and Alcohol-Related Harms in Pacific Islander Young Adults overallStatus: NOT_YET_RECRUITING date: 2024-09 date: 2028-05 date: 2028-08 date: 2024-03-29 date: 202... |
<|newrecord|> nctId: NCT06337708 id: STUDY00017286 id: R01HL168170 type: NIH link: https://reporter.nih.gov/quickSearch/R01HL168170 briefTitle: Smart Walk: A Culturally Tailored Smartphone-Delivered Physical Activity Intervention for African American Women overallStatus: RECRUITING date: 2024-01-19 date: 2027-03-31 dat... |
<|newrecord|> nctId: NCT06337695 id: HREBA.CC-23-0271 briefTitle: VERIFY: Vedolizumab for the Prevention of Immune Checkpoint Inhibitor Related Diarrhea or Colitis in Patients With Cancer overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2026-11-01 date: 2026-12-01 date: 2024-03-29 date: 2024-04-02 name: Univers... |
<|newrecord|> nctId: NCT06337682 id: CB_CY_P09_23_11 briefTitle: Blood Pressure Management in the Care Home Population acronym: BPITCH overallStatus: ACTIVE_NOT_RECRUITING date: 2016-01 date: 2020-01 date: 2024-06 date: 2024-03-29 date: 2024-03-29 name: University of Leeds class: OTHER name: Bradford Teaching Hospitals... |
<|newrecord|> nctId: NCT06337669 id: OSRSCP-GUP21006 briefTitle: Characterization of DupEx2 Duchenne Muscular Dystrophy acronym: DMDDup2 overallStatus: RECRUITING date: 2022-01-31 date: 2025-01-31 date: 2025-01-31 date: 2024-03-29 date: 2024-03-29 name: IRCCS San Raffaele class: OTHER briefSummary: To characterize the ... |
Background/Rationale DMD is caused by mutations in the DMD gene and in 11% of cases is due to duplications. The most promising therapeutic approaches include mutation-specific therapies. Notably, there is increasing evidence that specific groups of mutations may underlie different disease trajectories compared to the "... |
Dup2 is the most common DMD duplication and the only one for which a AAV-mediated exon skipping study is ongoing. Despite most case series and databases ascribe Dup2 to severe phenotype, our preliminary findings sustain that these patients have collectively a milder progression of the disease and in 1/3 of cases a sign... |
Research design and methods Clinical information regarding a cohort of 26 Italian Dup2 patients will be collected. Differences in time to loss of ambulation compared to a DMD control group will be achieved. Finally, we will retrieve DNA for correlative WGS studies. |
Anticipated output We expect that Dup2 patients present a milder DMD phenotype , which might be predicted by genomic studies. conditions: Muscular Dystrophy, Duchenne studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 26 type: ESTIMATED measure: Age at loss of ambulation measure: Ti... |
<|newrecord|> nctId: NCT06337656 id: VITAL_0 briefTitle: Vibration Training Approach in Liver Cirrhosis acronym: VITAL overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-10-01 date: 2026-04-01 date: 2024-03-29 date: 2024-04-01 name: University Hospital of Cologne class: OTHER briefSummary: * Comprehensive In... |
* Simultaneous Characterization and Evaluation of Dynamic Changes in Health-Related Quality of Life in our Patient Cohort with Liver Cirrhosis and Sarcopenia through Side-Alternating Whole-Body Vibration Training. conditions: Liver Cirrhosis studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionMo... |
<|newrecord|> nctId: NCT06337643 id: MVX01-01 briefTitle: A Study to Evaluate Tolerability, Safety and Immunogenicity of MVX01 Pneumococcal Vaccine overallStatus: ACTIVE_NOT_RECRUITING date: 2023-03-07 date: 2024-04-16 date: 2024-04-16 date: 2024-03-29 date: 2024-03-29 name: Matrivax Research and Development Corporatio... |
<|newrecord|> nctId: NCT06337630 id: IC 2022-10 briefTitle: A Study on Tuvusertib (Oral ATR Inhibitor) in Combination With PLX038 (Topo1 Inhibitor) in Patients With Advanced Solid Tumors acronym: POP-ART overallStatus: NOT_YET_RECRUITING date: 2024-06-15 date: 2025-06-15 date: 2029-02-15 date: 2024-03-29 date: 2024-03-... |
<|newrecord|> nctId: NCT06337617 id: CDRB436B2407 briefTitle: A Multi-center Retrospective Study With Secondary Use of Data of Tafinlar (Dabrafenib) Plus Mekinist (Trametinib) in Chinese Patients With BRAF V600 Mutation Positive Melanoma overallStatus: COMPLETED date: 2022-05-10 date: 2023-06-29 date: 2023-06-29 date: ... |
<|newrecord|> nctId: NCT06337604 id: TNP-2092-04 briefTitle: The Safety and Tolerability, Pharmacokinetics of TNP-2092 Capsules in Combination With Rabeprazole Sodium Enteric-coated Tablets overallStatus: COMPLETED date: 2017-10-10 date: 2017-11-23 date: 2017-11-23 date: 2024-03-29 date: 2024-04-01 name: TenNor Therape... |
<|newrecord|> nctId: NCT06337591 id: INRCA_003_2024 briefTitle: Diagnostic Performance of the Vesical Imaging-Reporting and Data System (VI-RADS) in Detecting Muscle-invasive Bladder Tumour (MIBC) in Clinical Practice: Comparison With Transurethral Resection of Bladder Cancer (TURB) and Evaluation of Diagnostic Accurac... |
<|newrecord|> nctId: NCT06337578 id: 23C308 briefTitle: Advances in Telephone-based Cognitive Screening Procedures acronym: TBCS overallStatus: RECRUITING date: 2023-10-25 date: 2026-10-25 date: 2026-10-25 date: 2024-03-29 date: 2024-03-29 name: Istituto Auxologico Italiano class: OTHER briefSummary: 1. Background |
Cognitive screening procedures via performance-based tests represent an essential, albeit preliminary, element within the diagnostic and interventional process as addressed to patients with chronic neurological disorders. Furthermore, in these populations, cognitive screening measures are often employed as outcomes ... |
The need for such clinimetric and feasibility studies is even more true if referred to telephone-based cognitive screening (TBCS) procedures - which, until recently, have been mostly neglected in Italy, despite having the potential to bring clear benefits to clinical practice and research. In fact, TBCS techniques a... |
2. Aims |
The present study primarily aims to provide exhaustive evidence regarding the psychometric, diagnostic and both cross-sectional and longitudinal clinical usability of TBCS that are currently available within the Italian scenario in populations with chronic neurological disorders. Secondly, this study aims to derive,... |
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