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<|newrecord|> nctId: NCT06315530 id: sh12053 briefTitle: Effect of Telitacicept on Antibody Titers in Primary APS Patients overallStatus: RECRUITING date: 2023-01-01 date: 2025-12-31 date: 2026-12-31 date: 2024-03-18 date: 2024-03-18 name: Ruijin Hospital class: OTHER briefSummary: The purpose of this study is to evalu... |
<|newrecord|> nctId: NCT06315517 id: AU24 id: 1792-23P type: OTHER_GRANT domain: The Dairy Alliance briefTitle: Double Crossover Casein Type Tolerance Trial overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2024-08 date: 2024-12 date: 2024-03-18 date: 2024-04-05 name: Auburn University class: OTHER briefSummary: Th... |
<|newrecord|> nctId: NCT06315504 id: Nephrotic Syndrome Cohort briefTitle: Circulating Factors in Nephrotic Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2034-04-01 date: 2034-04-01 date: 2024-03-18 date: 2024-03-19 name: Iain Bressendorff class: OTHER briefSummary: A prospective observational study... |
<|newrecord|> nctId: NCT06315491 id: CBX-12-201 briefTitle: A Study of CBX 12 in Subjects With Platinum Resistant or Refractory Ovarian Cancer overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2026-04 date: 2026-04 date: 2024-03-18 date: 2024-03-18 name: Cybrexa Therapeutics class: INDUSTRY briefSummary: The purpos... |
<|newrecord|> nctId: NCT06315478 id: Hybrid regimen for H.pylori briefTitle: Safety and Efficacy of Triple and Quadruple Regimens as First Line Therapy for Management of Helicobacter Pylori Infection in Egyptians overallStatus: COMPLETED date: 2021-02-01 date: 2021-03-16 date: 2021-11-01 date: 2024-03-18 date: 2024-03-... |
<|newrecord|> nctId: NCT06315465 id: AIIMSA00647 briefTitle: Efficacy of MAD as add-on Therapy in Comparison With Standard of Care in Children With ASD overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2026-01-01 date: 2026-01-01 date: 2024-03-18 date: 2024-03-18 name: All India Institute of Medical Sciences, Ne... |
Studies have shown that KD also helps in improvement of cognition, social skills, language function, and stereotypies. There is a limited number of reports of improvements after KD treatment, was insufficient evidence to attest the practicability of the KD as a treatment for ASD, but it is still a good indicator that t... |
This study aims to provide valuable insights that it can improve behavioral symptoms in ASD, early and ultimately improve the developmental outcomes in these children. conditions: Modified Atkins Diet conditions: Autism Spectrum Disorder conditions: Standard of Care studyType: INTERVENTIONAL phases: PHASE2 phases: PHAS... |
<|newrecord|> nctId: NCT06315452 id: PremaVitaD briefTitle: FREQUENCY OF VITAMIN D DEFICIENCY IN PREMATURE NEWBORN BORN BEFORE 32 WEEKS AND/OR WITH A BIRTH WEIGHT UNDER 1500g acronym: PremaVitaD overallStatus: ACTIVE_NOT_RECRUITING date: 2022-02-01 date: 2024-02-01 date: 2024-06-01 date: 2024-03-18 date: 2024-03-18 nam... |
The aim of this study was to determine the frequency of vitamin D deficiency in premature newborns. conditions: Vitamin D Deficiency studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 110 type: ACTUAL measure: Vitamine D deficiency frequency measure: vitamine D deficiency and mate... |
<|newrecord|> nctId: NCT06315439 id: Multi-RELAMI briefTitle: Digital Confocal Microscopy for Real-time Diagnosis of Pancreatic Solid Lesion acronym: Multi-RELAMI overallStatus: COMPLETED date: 2023-01-01 date: 2023-11-30 date: 2023-11-30 date: 2024-03-18 date: 2024-03-18 name: Campus Bio-Medico University class: OTHER... |
Ex-vivo fluorescence confocal laser microscopy (FCM) with MAVIG VivaScope® 2500M-G4 could allow real time assessment of adequacy and diagnosis of the sample. conditions: Pancreas Adenocarcinoma conditions: Endoscopic Ultrasound conditions: Digital Pathology studyType: OBSERVATIONAL observationalModel: COHORT timePerspe... |
<|newrecord|> nctId: NCT06315426 id: GR1802-011 briefTitle: A Study of IL4Rα Monoclonal Antibody in Patients With Seasonal Allergic Rhinitis(SAR). overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-10 date: 2024-12 date: 2024-03-18 date: 2024-03-21 name: Genrix (Shanghai) Biopharmaceutical Co., Ltd. class: INDU... |
<|newrecord|> nctId: NCT06315413 id: Composite plug vs d-PTFE briefTitle: Composite Plug vs d-PTFE Membrane in Socket Preservation overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2025-08-01 date: 2025-12-01 date: 2024-03-18 date: 2024-03-18 name: Cairo University class: OTHER briefSummary: The aim of the curre... |
<|newrecord|> nctId: NCT06315400 id: ING-07-2023 briefTitle: Efficacy and Safety of Ingavirin®, Capsules, 60 mg, in Children With Influenza and Other Acute Respiratory Viral Infections overallStatus: RECRUITING date: 2023-12-19 date: 2025-12-31 date: 2025-12-31 date: 2024-03-18 date: 2024-04-01 name: Valenta Pharm JSC ... |
<|newrecord|> nctId: NCT06315387 id: GIB-01-01-2023 briefTitle: Safety, Tolerability and Pharmacokinetics of 4-MUST, Tablets, 128 mg (Valenta Pharm JSC) During Single and Multiple Oral Administration in Healthy Volunteers overallStatus: RECRUITING date: 2023-12-04 date: 2024-12-31 date: 2024-12-31 date: 2024-03-18 date... |
<|newrecord|> nctId: NCT06315374 id: FJUH112267 briefTitle: 3D-Printed Aerosolized Medication Delivery Assist Device in Patients With Chronic Respiratory Diseases overallStatus: NOT_YET_RECRUITING date: 2024-03-30 date: 2024-07-31 date: 2024-07-31 date: 2024-03-18 date: 2024-03-19 name: Fu Jen Catholic University class... |
<|newrecord|> nctId: NCT06315361 id: 2445 briefTitle: DIAbetes and NAFLD acronym: DIANA overallStatus: ACTIVE_NOT_RECRUITING date: 2019-05-20 date: 2035-12-31 date: 2035-12-31 date: 2024-03-18 date: 2024-03-18 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: Non-alcoholic hep... |
The clinical impact of NAFLD in diabetes is considerable and represents a real driver of the major clinical outcomes that impact on the health of the individual, consequently creating a real 'burden of disease' especially in those populations considered to be at higher risk of disease severity. |
Individuals with diabetes are, in fact, those at greatest risk of developing the clinical sequelae of NAFLD and often do not receive adequate hepatological support and a correct hepatic pathology. In fact, it has been documented in the literature that the presence of diabetes increases the severity of liver damage, bri... |
In subjects with diabetes, moreover, the presence of NAFLD is not only associated with worse glycaemic control, but also with micro- and macro-vascular complications as well as nephrological and neuropathic complications and increased mortality. |
Therefore, the possibility of applying the non-invasive fibrosis scores currently available for NAFLD on a large scale, in a population at high risk of progressive liver disease, would make it possible to characterise (a) the true epidemiology of significant fibrosis (F3 or higher); (b) allow primary prevention actions... |
<|newrecord|> nctId: NCT06315348 id: URI_116301123 briefTitle: Effect on Periodontal Phenotype of Flapless Piezoincission During Orthodontic Treatment acronym: Piezo_Ortho overallStatus: RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-03-18 date: 2024-03-21 name: Universidad Complutense de Madrid class:... |
While the reduction in treatment times and the patient satisfaction after periodontally accelerated osteogenic orthodontics (PAOO) are well sustained in the scientific literature, there is still controversy regarding if grafting leads to i) change of the periodontal phenotype and ii) greater stability of post-orthodont... |
Aims of the Project |
The aim of this randomized clinical trial (RCT) is to compare piezocision-assisted orthodontics, concomitant to soft tissue grafting (volume-stable collagen matrix), with piezocision-assisted orthodontics, concomitant to bone grafting with a xenograft and a native collagen membrane, in orthodontic non-growing patients.... |
<|newrecord|> nctId: NCT06315335 id: UP0118 briefTitle: A Study to Assess the Safety and Pharmacokinetics of a Single Dose of UCB9741 in Healthy Caucasian and Japanese Participants overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2025-07-29 date: 2025-07-29 date: 2024-03-18 date: 2024-04-16 name: UCB Biopharma SRL... |
<|newrecord|> nctId: NCT06315322 id: EP0224 id: 2023-508095-11-00 type: REGISTRY domain: EU Trial Number id: U1111-1303-1174 type: OTHER domain: Universal Trial Number briefTitle: A Study to Test the Long-term Safety and Tolerability of Brivaracetam in Study Participants With Childhood Absence Epilepsy or Juvenile Abse... |
<|newrecord|> nctId: NCT06315309 id: IRB-300012281 (UAB 23146) briefTitle: Trial of 2 Step ATG for Acute GVHD Prevention Post Myeloablative Allogeneic Stem Cell Transplant overallStatus: NOT_YET_RECRUITING date: 2024-06-29 date: 2025-10-29 date: 2027-02 date: 2024-03-18 date: 2024-04-03 name: University of Alabama at B... |
<|newrecord|> nctId: NCT06315296 id: iRISID-2023-1985 briefTitle: An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer overallStatus: RECRUITING date: 2023-12-13 date: 2028-06-30 date: 2028-... |
<|newrecord|> nctId: NCT06315283 id: TV44749-BA-10196 id: 2023-505664-11-00 type: REGISTRY domain: CTIS briefTitle: An Open-Label Trial to Assess the Comparative Bioavailability of TV-44749 to Oral Olanzapine in Participants With Schizophrenia overallStatus: RECRUITING date: 2024-03-20 date: 2025-04-15 date: 2025-04-15... |
A secondary objective of this trial is to evaluate the safety and tolerability of multiple doses of TV-44749 administered sc in participants with schizophrenia. |
Another secondary objective of this trial is to compare additional pharmacokinetic parameters of TV-44749 administered sc with oral olanzapine (ZYPREXA®) at steady state in participants with schizophrenia. |
The total duration of participation in the trial for each participant is planned to be approximately 21 weeks. conditions: Schizophrenia studyType: INTERVENTIONAL phases: PHASE1 allocation: NON_RANDOMIZED interventionModel: CROSSOVER primaryPurpose: TREATMENT masking: NONE count: 116 type: ESTIMATED name: TV-44749 name... |
<|newrecord|> nctId: NCT06315270 id: 24K040-001 briefTitle: To Explore the Feasibility of Dynamic Changes of TCR Diversity in Peripheral Blood in Monitoring Recurrence and Evaluating Prognosis of Epithelial Ovarian Cancer overallStatus: NOT_YET_RECRUITING date: 2024-03-20 date: 2029-03-20 date: 2029-03-20 date: 2024-03... |
<|newrecord|> nctId: NCT06315257 id: J23105sIRB id: IRB00388854 type: OTHER domain: Johns Hopkins briefTitle: A Clinical Trial to Assess PVX7 Immunotherapy Regimens in Advanced Cervical Cancer Patients overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2026-08 date: 2027-03 date: 2024-03-18 date: 2024-03-18 name: Si... |
<|newrecord|> nctId: NCT06315244 id: 2558 briefTitle: Perforating Cutaneous Nerve Injection Efficacy in Chronic Coccydynia: A Randomized, Double-Blind Study overallStatus: RECRUITING date: 2024-04-01 date: 2024-07-01 date: 2024-10-01 date: 2024-03-18 date: 2024-03-18 name: Sisli Hamidiye Etfal Training and Research Hos... |
<|newrecord|> nctId: NCT06315231 id: SIM0308-02-Y-2-201 briefTitle: Edaravone Dexborneol Sublingual Tablet for the PSCI in Acute Ischemic Stroke Patients overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2024-12-31 date: 2025-05-30 date: 2024-03-18 date: 2024-03-18 name: Simcere Pharmaceutical Co., Ltd class: OT... |
The goal of this clinical trial is to assess the safety and efficacy of edaravone dexborneol sublingual tablets for post-stroke cognitive impairment in patients with acute ischemic stroke. |
Participants will be required to receive 12 weeks treatment of edaravone dexborneol sublingual tablets or placebo during this study. The safety and efficacy endpoints will be compared in the patients with edaravone dexborneol sublingual tablets or placebo. conditions: Post-stroke Cognitive Impairment studyType: INTERVE... |
<|newrecord|> nctId: NCT06315218 id: Pro2023000968 briefTitle: Examining the Health Effects of iTHRIVE 365 Among Black Same Gender Loving Men overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2028-04 date: 2028-04 date: 2024-03-18 date: 2024-03-21 name: Rutgers, The State University of New Jersey class: OTHER name:... |
<|newrecord|> nctId: NCT06315205 id: ROV-LEBE-2023-01 id: 2023-503948-13 type: EUDRACT_NUMBER briefTitle: Evaluation of the Pharmacokinetics, Safety, and Tolerability of IM Letrozole LEBE in Healthy Post-menopausal Women acronym: LEILA-1 overallStatus: RECRUITING date: 2023-07-26 date: 2025-01 date: 2025-01 date: 2024-... |
<|newrecord|> nctId: NCT06315192 id: CIV-22-10-041006 briefTitle: Stroke Alarm Efficacy Trial acronym: StrokeAlarmEFF overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-12-31 date: 2026-06-30 date: 2024-03-18 date: 2024-03-18 name: Region Skane class: OTHER briefSummary: The aim of this study is to test the ... |
This is a multicenter, prospective observational single-arm trial with a registry-based propensity matched control population. |
A total of 500 patients will be included in the trial. An interim analysis will determine if the stroke onset frequency is sufficient to determine the main outcome. Should the number of stroke events differ from what is expected at interim analysis, study enrollment will continue to increase cohort size. |
Patients who meet the criteria for participation will, after signing consent, be included and receive the Stroke Alarm bracelets that are used for 3 months. Study data will be collected as baseline at inclusion, at follow-up 3 months after inclusion and by using national Swedish registry data after completion of the st... |
Patients with elevated stroke risk according assessed by presence of specific criteria associated with elevated risk caused by: |
1. recent TIA, OR |
2. recent stroke without persisting arm motor deficit, OR |
3. atrial fibrillation A control population matched for age, sex, NIHSS score and health care region will be identified in the Swedish national stroke registry, Riksstroke, and used for comparison. |
The combined efficacy goal is at least 60% sensitivity for Stroke Alarm b of stroke with unilateral arm motor deficit within 3 hours of onset (with a 95% confidence interval above 30%) and a specificity of at least 80% using a clinical stroke diagnosis as gold standard. conditions: Stroke Acute conditions: Atrial Fibri... |
<|newrecord|> nctId: NCT06315179 id: STUDY00004616 briefTitle: Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE) acronym: STRIDE overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2028-01 date: 2030-01 date: 2024-03-18 date: 2024-03-19 name: Seattle Children's Hospital class: ... |
<|newrecord|> nctId: NCT06315166 id: CIP-PLG_CLINICAL-22-04 briefTitle: Study on Using Radiofrequency to Treat Moderate to Severe Acne overallStatus: RECRUITING date: 2024-04-10 date: 2025-09 date: 2025-12 date: 2024-03-18 date: 2024-04-11 name: Pollogen class: INDUSTRY name: Lumenis Be Ltd. briefSummary: Evaluation of... |
<|newrecord|> nctId: NCT06315153 id: KS2023077-1 briefTitle: Comprehensive Assessment of Atherosclerotic Ischemic Stroke Risk and Development of a Prediction Model acronym: CAIS-pre overallStatus: ACTIVE_NOT_RECRUITING date: 2022-01-03 date: 2024-04-01 date: 2026-04-01 date: 2024-03-18 date: 2024-03-18 name: Xuanwu Hos... |
The objectives of the study were as follows: first, to integrate the degree of carotid stenosis and plaque characteristics assessed by vascular ultrasound for a comprehensive assessment of plaque vulnerability; second, to develop an assessment tool for the risk of future ischemic stroke in patients with asymptomatic ca... |
The main questions it aims to answer are: |
* How to screen high-risk patients and those eligible for revascularization from asymptomatic carotid stenosis patients for primary prevention of stroke. |
* How to improve the prediction accuracy of atherosclerotic ischemic stroke based on existing prediction models for secondary prevention of stroke. conditions: Carotid Stenosis conditions: Ischemic Stroke studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: OTHER count: 500 type: ESTIMATED measure: The ... |
<|newrecord|> nctId: NCT06315140 id: 22-00248 id: 1R01ES033545-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R01ES033545-01 id: 5R01ES033545-02 type: NIH link: https://reporter.nih.gov/quickSearch/5R01ES033545-02 briefTitle: Assessing and Addressing Community Exposures to Environmental Contaminants overallSt... |
* Collect in-person/online survey information on demographics, health and food intake, nutrition, food security, and psychosocial stressors, and perform core anthropometric measurements (i.e., height, weight, body mass index, body circumference and blood pressure) at enrollment on Tribal members to inform health promot... |
* Determine individual-level contaminant burdens and micronutrient concentrations (e.g., iron, calcium, folate, vitamins) in urine and blood from surveyed (sub-aim 1a) Ramapough Turtle Clan volunteers. |
* Test soil, plants and surface water where Turtle Clan residents live, recreate and attend church in Ringwood, NJ using a community-based, citizen scientist approach. conditions: Environmental Exposure studyType: OBSERVATIONAL observationalModel: ECOLOGIC_OR_COMMUNITY timePerspective: PROSPECTIVE count: 400 type: ESTI... |
<|newrecord|> nctId: NCT06315127 id: 23-0119-A briefTitle: The CanDo (Canadian Donor Milk) Trial overallStatus: RECRUITING date: 2023-11-28 date: 2024-11-28 date: 2025-03-31 date: 2024-03-18 date: 2024-03-18 name: Mount Sinai Hospital, Canada class: OTHER name: Mitacs briefSummary: The goal of this clinical trial is to... |
<|newrecord|> nctId: NCT06315114 id: p-2023-15049 id: H-23064491 type: OTHER domain: Regional Committee of Health Research Ethics (VEK) briefTitle: A Transdiagnostic Mentalization-based Intervention for Parents With Mental Disorders acronym: LIGHTHOUSE overallStatus: RECRUITING date: 2024-03-11 date: 2028-04-01 date: 2... |
<|newrecord|> nctId: NCT06315101 id: K-2023-092 briefTitle: Effectiveness and Safety of Lenvatinib Combined With Chinese Herbal Medicine for Patients With Unresectable Hepatocellular Carcinoma: A Real-world Study in China overallStatus: COMPLETED date: 2023-09-01 date: 2023-12-31 date: 2023-12-31 date: 2024-03-18 date:... |
<|newrecord|> nctId: NCT06315088 id: 69HCL24_0144 briefTitle: Food Biodiversity and Human Health acronym: BIOQUALIM overallStatus: NOT_YET_RECRUITING date: 2024-10-01 date: 2025-03-01 date: 2025-03-01 date: 2024-03-18 date: 2024-03-18 name: Hospices Civils de Lyon class: OTHER briefSummary: In Western countries, one of... |
Furthermore, for several years, public health studies have indicated a chronic deficit in micronutrients (minerals/trace elements, vitamins, antioxidants) as well as fiber in the diet of the French population. This comes in particular from the impoverishment of the nutritional quality of the fruits/vegetables/cereals/l... |
The benefit of plant-based diets to reduce the risk of cancer is now established. In addition, certain cereals such as spelled have superior nutritional qualities to common wheat, notably their protein content and they also contain higher quantities of certain bioactive compounds with anti-cancer properties (such as ph... |
Furthermore, the potential impact of the oral microbiota on chronic diseases is now being studied: in healthy adults, a dysbiotic periodontal microbiota may be likely to lead to systemic para-inflammation. It has also been shown that a dietary change (Mediterranean diet) could lead to a reduction in pathogenic bacteria... |
This pilot clinical study plans to focus on the oral microbiota, with the aim of objectivizing a possible link between a modification of the diet by the introduction of cereals (einkorn type) and the evolution of certain bacteria of this microbiota. , notably P. gingivalis (but also T. forsythia, S. anginosus, A. actin... |
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