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* Their disease progresses, or another illness interferes with taking the study drug, or |
* The sponsors stops the study. conditions: RAS Mutation conditions: NF1 Mutation conditions: RAF Mutation conditions: Advanced Solid Tumors studyType: INTERVENTIONAL phases: PHASE1 allocation: NA interventionModel: SEQUENTIAL interventionModelDescription: 3+3 dose expansion primaryPurpose: TREATMENT masking: NONE coun... |
<|newrecord|> nctId: NCT06299826 id: D9090C00008 briefTitle: A Phase IIb Study of AZD5462 in Patients With Chronic Heart Failure acronym: LUMINARA overallStatus: NOT_YET_RECRUITING date: 2024-06-10 date: 2025-11-24 date: 2025-11-24 date: 2024-03-08 date: 2024-03-08 name: AstraZeneca class: INDUSTRY briefSummary: The ma... |
<|newrecord|> nctId: NCT06299813 id: 771.284 id: 2022-002955-20 type: EUDRACT_NUMBER briefTitle: Effectiveness of a Single Dose of Betamethasone in Children With Symptomatic Adenovirus Infection acronym: Adeno-beta overallStatus: RECRUITING date: 2024-03-20 date: 2025-01-15 date: 2026-04-01 date: 2024-03-08 date: 2024-... |
The experimentation is conducted to answer this question: "Can betamethasone help reduce fever more quickly in a child with viral adenovirus infection? "The secondary objective is to assess if the child's overall clinical conditions improve more rapidly (reduced sore throat, quicker return to regular eating) and a redu... |
<|newrecord|> nctId: NCT06299800 id: CE385/2023 briefTitle: Phenotyping Patients With Type 2 Diabetes Mellitus and Cancer acronym: TCPT2023 overallStatus: RECRUITING date: 2024-02-04 date: 2025-02-04 date: 2025-02-04 date: 2024-03-08 date: 2024-03-08 name: Azienda Ospedaliero Universitaria Maggiore della Carita class: ... |
Primary objective of the study: |
- identify the risk factors affecting the occurrence of cancer in the population affected by type 2 diabetes mellitus; |
Secondary objectives of the study: |
* description of the demographic, clinical and first-line therapy characteristics of patients diagnosed with type 2 diabetes mellitus; |
* assess risk factors for recurrence, presence of a second tumour not related to the first and the presence of both events in patients who have had a tumor within 10 years of diagnosis of diabetes; |
* assess the relationship between the characteristics of patients and the time to the onset of cancer. conditions: Diabetes Mellitus, Type 2 conditions: Cancer studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: RETROSPECTIVE count: 779 type: ESTIMATED name: phenotyping of patients followed at a third-... |
<|newrecord|> nctId: NCT06299787 id: 058-2021 briefTitle: Cognitive Dysfunction in the Addictions Study - Project 4 (P4) acronym: CDiA-P4 overallStatus: RECRUITING date: 2022-02-07 date: 2024-12-31 date: 2025-07-01 date: 2024-03-08 date: 2024-03-08 name: Centre for Addiction and Mental Health class: OTHER briefSummary:... |
<|newrecord|> nctId: NCT06299774 id: 2023P003383 briefTitle: Emergency Care at Home overallStatus: RECRUITING date: 2024-02-02 date: 2025-02-02 date: 2025-03-02 date: 2024-03-08 date: 2024-03-08 name: Brigham and Women's Hospital class: OTHER briefSummary: This study will assess the efficacy of receiving emergency care... |
<|newrecord|> nctId: NCT06299761 id: BBI-825-101 briefTitle: Study of the RNR Inhibitor BBI-825 in Subjects With Tumors With Resistance Gene Amplifications acronym: STARMAP overallStatus: RECRUITING date: 2024-03-28 date: 2027-02 date: 2027-02 date: 2024-03-08 date: 2024-04-29 name: Boundless Bio class: INDUSTRY briefS... |
<|newrecord|> nctId: NCT06299748 id: ARGX-113-PAC-2206 briefTitle: A Worldwide Pregnancy Safety Study to Assess Maternal, Fetal, and Infant Outcomes Following Exposure to Efgartigimod During Pregnancy and/or Breastfeeding. overallStatus: NOT_YET_RECRUITING date: 2024-02-29 date: 2033-12 date: 2033-12 date: 2024-03-08 d... |
<|newrecord|> nctId: NCT06299735 id: AsenaIremYildiz1 briefTitle: Comparison of Airway Management With Bronchial Blocker and Double-Lumen Tube in Single-Lung Ventilation overallStatus: RECRUITING date: 2024-02-01 date: 2024-08-31 date: 2024-09-30 date: 2024-03-08 date: 2024-04-17 name: Ankara City Hospital Bilkent clas... |
<|newrecord|> nctId: NCT06299722 id: N-20230055 briefTitle: Strength Training Exercises to Minimise Late Effects of Childhood Leukaemia or Lymphoma Among Adolescents acronym: STEEL overallStatus: RECRUITING date: 2024-03-15 date: 2025-07 date: 2025-07 date: 2024-03-08 date: 2024-03-19 name: Aalborg University class: OT... |
<|newrecord|> nctId: NCT06299709 id: VX23-121-012 briefTitle: A Study To Evaluate the Relative Bioavailability, Food Effect, and Dose Proportionality of a Granule Formulation of Vanzacaftor/Tezacaftor/Deutivacaftor(VNZ/TEZ/D-IVA) overallStatus: RECRUITING date: 2024-03-13 date: 2024-06 date: 2024-06 date: 2024-03-08 da... |
<|newrecord|> nctId: NCT06299696 id: VX23-121-011 briefTitle: A Study of Vanzacaftor/Tezacaftor/Deutivacaftor (VNZ/TEZ/D-IVA) in Healthy Adult Panelists overallStatus: ENROLLING_BY_INVITATION date: 2024-03-26 date: 2024-05 date: 2024-05 date: 2024-03-08 date: 2024-04-08 name: Vertex Pharmaceuticals Incorporated class: ... |
<|newrecord|> nctId: NCT06299683 id: 230487 id: 1R01DK133415-01A1 type: NIH link: https://reporter.nih.gov/quickSearch/1R01DK133415-01A1 briefTitle: Pain Type and Interstitial Cystitis/Bladder Pain Syndrome Treatment overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2027-04-05 date: 2028-08-04 date: 2024-03-08 d... |
<|newrecord|> nctId: NCT06299670 id: 939 briefTitle: Efficacy of Combination of Hdroxyurea and Thalidomide Over Either Hydroxyurea or Thalidomide Alone in the Treatment of Transfusion Dependent Thalassemia in Children: A Quasi-Randomised Clinical Trial overallStatus: RECRUITING date: 2023-11-01 date: 2024-06-30 date: 2... |
Recent studies with combination of HU and Thalidomide have shown promising results in treatment of Thalassemia patients. However, most of those studies are retrospective or single arm nonrandomized trials \& The study population includes both adult and children age group . So the effectiveness of combination therapy of... |
This single centered non blinded quasi randomized clinical trial will be conducted at the Department of Pediatric Hematology and Oncology in Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh for one year of period. Thirty transfusion dependent thalassemia children of 3-18 years old will be included in eac... |
<|newrecord|> nctId: NCT06299657 id: 2023H0286 briefTitle: Intervention for Managing Physical Reactions to Overwhelming Emotions acronym: IMPROVE overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-03 date: 2026-03 date: 2024-03-08 date: 2024-03-08 name: Ohio State University class: OTHER briefSummary: The clini... |
This study will enroll 40 adults who are currently enrolled in IOP, have a substance use disorder, and experience elevated anxiety. 20 individuals will be randomized to the experimental intervention, "Intervention for Managing Physical Reactions to Overwhelming Emotions" (IMPROVE), and 20 individuals will be randomized... |
Participants will be asked to complete a baseline assessment of mood, substance use, and psychophysiology. Participants will then completed ecological momentary assessments (EMA) via smartphone technology 4 times a day for \~ 28 days (the day following the baseline assessment until the 3rd intervention session). Partic... |
<|newrecord|> nctId: NCT06299644 id: 2023P003282 briefTitle: Endoscopic Sleeve Gastroplasty Technique Comparison for Weight Loss overallStatus: NOT_YET_RECRUITING date: 2025-05-01 date: 2026-07-01 date: 2026-12-31 date: 2024-03-08 date: 2024-03-08 name: Brigham and Women's Hospital class: OTHER name: Endo Tools Therape... |
<|newrecord|> nctId: NCT06299631 id: RECHMPL23_0187 briefTitle: Endoscopic Relapse Risks Evaluation After Ileocolic Resection for Crohn's Disease acronym: RIC-1 overallStatus: COMPLETED date: 2015-01 date: 2023-06 date: 2023-12 date: 2024-03-08 date: 2024-03-08 name: University Hospital, Montpellier class: OTHER name: ... |
To evaluate risk factors of endoscopic relapse after ileocolic resection in a cohort of Crohn's disease patients treated with anti-TNF agents. |
Methods: |
From 2014 to 2022, all consecutive patients who underwent ileocolic resection for Crohn's disease treated with anti-TNF agents in two referral tertiary center were prospectively collected. |
Considering exclusion criteria, data from 114 patients were analyzed. The cohort was separated into 2 groups according to study period. |
Short and long-term outcomes were compared between the two groups. |
Primary outcome: |
Endoscopic recurrence (defined as \> i2 lesions according to Rutgeerts classification) 6 months after surgery conditions: Crohn's Disease studyType: OBSERVATIONAL observationalModel: CASE_ONLY timePerspective: PROSPECTIVE count: 133 type: ACTUAL name: Ileocolic resection measure: Endoscopic recurrence rate measure: Res... |
<|newrecord|> nctId: NCT06299618 id: ENIGMA-I briefTitle: Environmental Influence on Mental Illness Via Modifications of Genomes and Metabolomes in Adolescents With Autism acronym: ENIGMA-I overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-05 date: 2025-12 date: 2024-03-08 date: 2024-03-08 name: University Col... |
<|newrecord|> nctId: NCT06299605 id: SHARE2401 briefTitle: Triple Versus Quadruple Therapy for the Eradication of Helicobacter Pylori acronym: SHARE2401 overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2024-10 date: 2024-11 date: 2024-03-08 date: 2024-03-08 name: Shandong University class: OTHER name: Binzhou Mate... |
<|newrecord|> nctId: NCT06299592 id: 2023-1626 id: 1RF1AG082215-01 type: NIH link: https://reporter.nih.gov/quickSearch/1RF1AG082215-01 id: A538900 type: OTHER domain: UW- Madison id: SMPH/PSYCHIATRY/PSYCHIATRY type: OTHER domain: UW- Madison id: Protocol Version 10/15/2023 type: OTHER domain: UW- Madison briefTitle: C... |
* How airway inflammation in asthma affects the brain; and, |
* Whether airway inflammation in asthma is related to symptoms of depression and anxiety |
Over the course of 3 visits, participants will: |
* Complete questionnaires |
* Complete computer tasks |
* Undergo allergy skin test and breathing tests |
* Give two blood samples |
* Give a sputum sample |
* Complete brain imaging scans |
Researchers will compare results between participants with asthma, and participants who do not have asthma. conditions: Asthma studyType: OBSERVATIONAL observationalModel: CASE_CONTROL timePerspective: PROSPECTIVE count: 100 type: ESTIMATED name: PET/MRI using [18F]FEPPA tracer measure: Binding of [18F]-FEPPA measure: ... |
<|newrecord|> nctId: NCT06299579 id: WG-GD11-III-01 briefTitle: GD-11 for Injection in the Treatment of Acute Ischemic Stroke overallStatus: RECRUITING date: 2024-02-29 date: 2025-02-22 date: 2025-12-31 date: 2024-03-08 date: 2024-03-15 name: Beijing Tiantan Hospital class: OTHER name: Jiangsu Wangao Pharmaceutical Co.... |
<|newrecord|> nctId: NCT06299566 id: CF NGS briefTitle: Perceptions of the CF Screening Protocol Incorporating NGS overallStatus: COMPLETED date: 2022-01-19 date: 2023-02-28 date: 2023-02-28 date: 2024-03-08 date: 2024-03-08 name: King's College London class: OTHER name: University of Warwick name: Coventry University ... |
A trial of NGS in one centre in the UK, for one year found that it was technically feasible at reasonable cost and with an acceptable turn around time. In addition, the trial determined that using NGS could mitigate against some of the disadvantages described above. |
The purpose of this piece of work was to: |
1. Gather, compare and analyse the views of a range of stakeholders on the proposed CF screening protocol incorporating NGS. |
2. Use the outcomes to inform discussions and decisions by the fetal, maternal and child health (FMCH) group and UK National Screening Committee (NSC) about the proposed protocol |
3. Consider what generalisable information on the views of stakeholders on newborn screening could be generated from this exercise to inform other FMCH and UK NSC discussions |
4. Evaluate and learn from the exercise to inform future stakeholder engagement activities by the UK NSC and screening programmes. conditions: Cystic Fibrosis studyType: OBSERVATIONAL observationalModel: OTHER timePerspective: PROSPECTIVE count: 150 type: ACTUAL measure: Focus groups/interviews/questionnaires exploring... |
<|newrecord|> nctId: NCT06299553 id: INCB88888-040 PRO-MIND briefTitle: Study to Evaluate the Effectiveness of Tafasitamab in Combination With Lenalidomide Followed by Tafasitamab Monotherapy in Relapsed or Refractory Diffuse Large B-cell Lymphoma Non-transplant Eligible Patients in Italy (PRO-MIND) overallStatus: RECR... |
<|newrecord|> nctId: NCT06299540 id: 54179060CLL4033 id: 54179060CLL4033 type: OTHER domain: Janssen-Cilag France briefTitle: Benefits of Individual Physical Activity Intervention on Health-related Quality of Life in Participants With Chronic Lymphocytic Leukemia acronym: QOLIBRI overallStatus: NOT_YET_RECRUITING date:... |
<|newrecord|> nctId: NCT06299527 id: 01032024 briefTitle: Telerehabilitation in Patients With Fibromyalgia overallStatus: COMPLETED date: 2023-05-27 date: 2023-11-15 date: 2024-01-27 date: 2024-03-08 date: 2024-03-13 name: Marmara University class: OTHER briefSummary: Sixty-six FMS patients received the same exercise p... |
<|newrecord|> nctId: NCT06299514 id: 4754 briefTitle: RAFT-P&A Randomized Control Trial overallStatus: NOT_YET_RECRUITING date: 2024-03-10 date: 2028-12-31 date: 2029-12-31 date: 2024-03-08 date: 2024-03-12 name: Lawson Health Research Institute class: OTHER briefSummary: Atrial fibrillation (AF) is an irregular heartb... |
A complex pacemaker that stimulates both the right and left ventricles simultaneously (BiVP) has been used for the last decade prior to AV node ablation. More recently, a technique has been designed to reduce the number of leads in the heart, reduce procedure time and have a similar effect on the heart called Conductio... |
<|newrecord|> nctId: NCT06299501 id: LS 2015-1199 and 2017-24 briefTitle: How Can Child Health Services Identify and Respond to Family Violence overallStatus: COMPLETED date: 2017-08-23 date: 2019-08-31 date: 2019-08-31 date: 2024-03-07 date: 2024-03-08 name: Karolinska Institutet class: OTHER name: Jane and Dan Olsson... |
<|newrecord|> nctId: NCT06299488 id: PS03 briefTitle: Combined Effects of Prunus Cerasus and Apocynum Venetum On Sleep and Anxiety in Adults With Insomnia acronym: Sip2Sleep overallStatus: COMPLETED date: 2023-04-05 date: 2023-06-01 date: 2023-07-01 date: 2024-03-07 date: 2024-03-07 name: Lakshmi Nutraceuticals LLC cla... |
Participants in this study will complete a number of surveys about their difficulties falling asleep and staying asleep (insomnia), their energy level during the day and health status regarding their quality of sleep. |
There are no major risks associated with this study. conditions: Insomnia studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Participants will complete a 5-week study consisting of screening assessments, baseline scales and surveys, objective digit... |
<|newrecord|> nctId: NCT06299475 id: 2023-06755-01 briefTitle: Structured Online Contraceptive Counseling (LOWE Trial) at Emergency Contraception (EC) Pharmacy Provision LOWE+EC=LOWEC acronym: LOWEC overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2025-07 date: 2026-09 date: 2024-03-07 date: 2024-03-07 name: Karol... |
<|newrecord|> nctId: NCT06299462 id: PTCy-ATG-001 briefTitle: PTCy and ATG for MSD and MUD Transplants overallStatus: NOT_YET_RECRUITING date: 2024-05-21 date: 2031-06-01 date: 2031-06-01 date: 2024-03-07 date: 2024-03-07 name: Instituto Nacional de Cancer, Brazil class: OTHER_GOV briefSummary: Hematopoietic stem cell ... |
Since then, in view of this enormous success, efforts have been made to incorporate post-transplant cyclophosphamide in matched related and unrelated transplants, or with a mismatch. |
This is a prospective, 2-arm, non-randomized study. Arm 1, with related donors, and arm 2, with unrelated donors. Patients will be allocated in these arms according to donor availability (patients with a matched-sibling donor will receive a matched-sibling transplant; patients with no related donors but with unrelated ... |
Patients who are ready for transplantation with matched-sibling or unrelated donors will be recruited to participate in the study. |
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