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Electrical spinal cord stimulation (ESS) is a validated technique in the management of chronic neuropathic pain. Several publications suggest that it could be effective on postural disorders in PD. Thus, authors report the case of a Parkinson's patient afflicted with painful camptocormia refractory to drug treatments a... |
<|newrecord|> nctId: NCT06291038 id: 2021/0381/HP briefTitle: Efficacy of Glutamine Supplementation in Patients Suffering From Irritable Bowel Syndrome With Impaired Intestinal Permeability acronym: MISSISIIPI overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2029-03-01 date: 2029-03-01 date: 2024-03-04 date: 20... |
One of the functional abnormalities described during IBS is increased intestinal permeability. This increase in intestinal permeability is primarily present in the diarrheal subtype (IBS-D) and can be measured using the lactulose/mannitol test. |
Glutamine is a non-essential amino acid which regulates numerous metabolic pathways, and which plays a key role in the intestine because it is the preferential substrate of enterocytes and immune cells. Ex vivo, glutamine is able to restore the expression of tight junction proteins in patients suffering from IBS-D. On ... |
Our working hypothesis would be that all patients suffering from IBS with permeability disorder, measured by the lactulose/mannitol test, could benefit from oral glutamine supplementation. conditions: Irritable Bowel Syndrome studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interv... |
<|newrecord|> nctId: NCT06291025 id: 2021/0374/HP briefTitle: Efficacy and Safety of Immunosuppression, Caplacizumab and Plasma Infusion Without Therapeutic Plasma Exchange in Immune-mediated Thrombotic Thrombocytopenic Purpura: Multicentric Non-inferiority Single-arm Study acronym: PEX-FREE overallStatus: NOT_YET_RECR... |
<|newrecord|> nctId: NCT06291012 id: RECHMPL22_0399 id: 2024-512236-30-00 type: REGISTRY domain: EUCT Number briefTitle: Stopping Pneumonia Antibiotherapy Regimen Early acronym: SPARE overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2027-05-01 date: 2027-09-01 date: 2024-03-04 date: 2024-03-04 name: University ... |
<|newrecord|> nctId: NCT06290999 id: CHUBX 2023/80 briefTitle: Study of Multifrequential Impedancemetry in Pulsatile Tinnitus acronym: MADMAN overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2025-09-15 date: 2025-12-15 date: 2024-03-04 date: 2024-03-04 name: University Hospital, Bordeaux class: OTHER briefSumma... |
<|newrecord|> nctId: NCT06290986 id: Pyrocardan® RCT briefTitle: Pyrocardan® Implant Arthroplasty or LRTI for Trapeziometacarpal Osteoarthritis overallStatus: RECRUITING date: 2022-09-26 date: 2025-09-30 date: 2025-09-30 date: 2024-03-04 date: 2024-03-04 name: Herlev and Gentofte Hospital class: OTHER briefSummary: Thi... |
<|newrecord|> nctId: NCT06290973 id: PI-23-3017 briefTitle: Quality of Life and Health Perception After Surgery of Varicose Veins overallStatus: COMPLETED date: 2023-01-02 date: 2023-02-28 date: 2023-11-14 date: 2024-03-04 date: 2024-03-04 name: Hospital Clínico Universitario de Valladolid class: OTHER briefSummary: Th... |
<|newrecord|> nctId: NCT06290947 id: BFR-AE-DT2-2023-01 id: IRB 2022/C/20/N type: OTHER_GRANT domain: AAUP briefTitle: BFR Walking for Insulin and Aerobic Improvement in Type 2 Diabetes acronym: BRAID overallStatus: COMPLETED date: 2022-03-06 date: 2023-12-20 date: 2024-01-08 date: 2024-03-04 date: 2024-03-04 name: Ara... |
The primary objectives of the study are to determine: If Blood-Flow Restriction Walk Training (BFRw) can improve insulin sensitivity in individuals with Type 2 Diabetes (T2D). |
Whether Blood-Flow Restriction Walk Training (BFRw) enhances aerobic capacity in individuals with Type 2 Diabetes (T2D). |
Participants in the study are divided into two groups. One group undergoes Blood-Flow Restriction Walk Training (BFRw), and the other serves as a control. Both groups attend three treadmill walking sessions weekly for eight weeks. The BFRw group has a restriction cuff placed around both thighs during their sessions, wh... |
Hemoglobin A1c (HbA1c) levels and maximal oxygen consumption (VO2 max) are monitored as indicators of insulin sensitivity and aerobic capacity, respectively. conditions: Type 2 Diabetes Mellitus studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This st... |
<|newrecord|> nctId: NCT06290934 id: GS-US-409-5704 id: 2023-508304-38 type: OTHER domain: European Medicines Agency briefTitle: Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis acronym: SWIFT overallStatus: RECRUITING date: 2024-03-27 date: 2027-05 date: 2028-03 date: 2024-03-04 d... |
The primary objectives of this study are: |
Part 1: To assess the efficacy of GS-1427, compared with placebo control, in achieving clinical response at Week 12 |
Part 2: To assess the efficacy of combination therapy with GS-1427 and ustekinumab, compared with GS-1427 and ustekinumab monotherapies, in achieving clinical response at Week 12 conditions: Ulcerative Colitis studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: SEQUENTIAL primaryPurpose: ... |
<|newrecord|> nctId: NCT06290921 id: 3472 briefTitle: Ovulation Triggering 2 vs 3 Follicles overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-22 date: 2024-12-31 date: 2025-02-20 date: 2024-03-04 date: 2024-03-04 name: Clinique Ovo class: INDUSTRY briefSummary: Poor responders in in-vitro fertilization (IVF) cycles re... |
<|newrecord|> nctId: NCT06290908 id: TF2018-001-01 briefTitle: RPE-P/TLIF for Lumbar Spinal Stenosis With Instability overallStatus: COMPLETED date: 2018-09-04 date: 2022-04-30 date: 2024-02-01 date: 2024-03-04 date: 2024-03-04 name: Wen-xi Sun class: OTHER name: Guangdong Provincial Hospital of Traditional Chinese Med... |
<|newrecord|> nctId: NCT06290895 id: 3465 briefTitle: Artificial Oocyte Activation overallStatus: ACTIVE_NOT_RECRUITING date: 2024-02-22 date: 2024-12-31 date: 2025-02-19 date: 2024-03-04 date: 2024-03-04 name: Clinique Ovo class: INDUSTRY briefSummary: Studies reported that calcium signal deficiency or insufficiency d... |
<|newrecord|> nctId: NCT06290882 id: ERMA trial briefTitle: Endoscopic Versus Robotic Myotomy for Treatment of Achalasia acronym: ERMA overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-01 date: 2026-01-31 date: 2027-01-01 date: 2024-03-04 date: 2024-03-05 name: Germans Trias i Pujol Hospital class: OTHER briefSummary:... |
The purpose of the study is to evaluate the clinical and quality of life results of the RHM and compare them with the results of POEM in treatment of achalasia. conditions: Achalasia Cardia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: Randomized c... |
<|newrecord|> nctId: NCT06290869 id: STUDY00006070 briefTitle: Tobacco Education and Lung Health Study (TEAL) acronym: TEAL overallStatus: RECRUITING date: 2024-02-22 date: 2026-02 date: 2026-04 date: 2024-03-04 date: 2024-03-06 name: Georgetown University class: OTHER briefSummary: Primary Objective To compare two smo... |
Secondary Objectives 1) To evaluate reach and engagement overall and by subgroup (e.g., race and ethnicity, underinsured, readiness to quit). 2) To conduct an economic analysis to evaluate intervention costs from the health system perspective. conditions: Smoking Cessation studyType: INTERVENTIONAL phases: PHASE3 alloc... |
<|newrecord|> nctId: NCT06290856 id: 651397 briefTitle: Clinical Utility of Selected Circulating Tumor DNA Assays in Patients With Advanced Malignancy overallStatus: RECRUITING date: 2024-01-15 date: 2025-12-15 date: 2025-12-15 date: 2024-03-04 date: 2024-03-07 name: Oslo University Hospital class: OTHER briefSummary: ... |
<|newrecord|> nctId: NCT06290843 id: AWFiS/2024_1_PE briefTitle: Analysis of Body Balance Parameters in Children With Idiopathic Scoliosis overallStatus: NOT_YET_RECRUITING date: 2024-04-05 date: 2024-05-30 date: 2024-05-30 date: 2024-03-04 date: 2024-04-04 name: Gdansk University of Physical Education and Sport class:... |
<|newrecord|> nctId: NCT06290830 id: OMUŞükranBaşgöl01 briefTitle: Abdominal Massage and Kegel Exercises on Constipation and Quality of Life in Female Students overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-05-31 date: 2024-06-01 date: 2024-03-04 date: 2024-03-12 name: Ondokuz Mayıs University class: OTH... |
<|newrecord|> nctId: NCT06290817 id: 2023-0724 briefTitle: Orelabrutinib Combined With R-CDOP for DLBCL Patients With High-risk of CNS Relapse Defined by CNS-IPI overallStatus: RECRUITING date: 2023-03-30 date: 2025-03-30 date: 2026-03-20 date: 2024-03-04 date: 2024-03-04 name: Second Affiliated Hospital, School of Med... |
<|newrecord|> nctId: NCT06290804 id: drezgiyucel0000000193593877 briefTitle: Assessing Sustainable Behaviors and Health Impacts of Climate Change overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-15 date: 2024-03 date: 2024-07 date: 2024-03-04 date: 2024-03-04 name: Eskisehir Osmangazi University class: OTHER briefSum... |
<|newrecord|> nctId: NCT06290791 id: K2020214 briefTitle: Does a Drain Tube Influence the Postoperative Epidural Haematoma for Lumbar Biportal Endoscopic Surgery? overallStatus: COMPLETED date: 2020-12-31 date: 2023-12-31 date: 2024-02-10 date: 2024-03-04 date: 2024-03-04 name: The Fourth Affiliated Hospital of Zhejian... |
<|newrecord|> nctId: NCT06290778 id: Baylor IRB #023-445 briefTitle: Peer Delivered, Emotion Regulation-Focused Mental Health Prevention Training for Fire Fighter Trainees acronym: PEER UP overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2027-08 date: 2027-08 date: 2024-03-04 date: 2024-03-05 name: Baylor Research... |
* Do firefighter recruits who receive peer-delivered Brief-Unified Protocol report lower PTSD symptom severity over time compared to those who receive psychoeducation? |
* Do firefighter recruits who receive peer-delivered Brief-Unified Protocol report lower AUD, depression, anxiety, and functional impairment symptom severity over time compared to those who receive psychoeducation? |
* Do changes in neuroticism or emotion regulation mediate the effect of receiving the Brief-Unified Protocol on the treatment outcomes? |
Participants will: |
* Participate in a Brief-Unified Protocol workshop or psychoeducation workshop during fire academy training. |
* Complete a questionnaire and clinical interview prior to the workshop. |
* Complete a questionnaire immediately following the workshop and follow up questionnaires at 6, 12, 18, and 24 months after completing the fire academy. |
Researchers will compare firefighters who receive a peer-delivered Brief-Unified Protocol workshop to firefighters who receive peer-delivered psychoeducation to see if the Brief-Unified Protocol is effective for preventing posttraumatic stress and other psychological health symptoms. conditions: PTSD conditions: Alcoho... |
<|newrecord|> nctId: NCT06290765 id: A23-401 briefTitle: Efficacy and Safety of Ropeginterferon Alfa 2b (P1101) for Patients With Low-Risk Polycythemia Vera acronym: PV overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-12-31 date: 2027-02-28 date: 2024-03-04 date: 2024-03-04 name: PharmaEssentia class: INDU... |
<|newrecord|> nctId: NCT06290752 id: KY-2024-030 briefTitle: Determining the Learning Curve for Ultrasound-guided Caudal Epidural Block overallStatus: RECRUITING date: 2024-03-01 date: 2024-11-30 date: 2024-12-31 date: 2024-03-04 date: 2024-03-12 name: The Fourth Affiliated Hospital of Zhejiang University School of Med... |
<|newrecord|> nctId: NCT06290739 id: JHuang886 briefTitle: A Machine-learning Model to Predict Lymph Node Metastasis of Intrahepatic Cholangiocarcinoma overallStatus: RECRUITING date: 2024-02-07 date: 2024-03-07 date: 2024-03-27 date: 2024-03-04 date: 2024-03-04 name: West China Hospital class: OTHER briefSummary: The ... |
<|newrecord|> nctId: NCT06290726 id: 202001927B0 briefTitle: Long-term Outcomes of Living Donor Liver Transplantations With Anti-HBc (+) Grafts in Pediatric Patients overallStatus: COMPLETED date: 2002-02 date: 2016-02 date: 2024-01 date: 2024-03-04 date: 2024-03-05 name: Chang Gung Memorial Hospital class: OTHER brief... |
<|newrecord|> nctId: NCT06290713 id: IRB202301491 id: 1R21AR079755-01 type: NIH link: https://reporter.nih.gov/quickSearch/1R21AR079755-01 id: PRO00050023 type: OTHER domain: UFIRST briefTitle: Vasodilator and Exercise Study for DMD (VASO-REx) overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-11 date: 2026-11 ... |
<|newrecord|> nctId: NCT06290700 id: MCBU_2880 briefTitle: Effect of Neonatal Care Education for Primiparous Pregnant Women on Postpartum Maternal Function and Quality of Life overallStatus: COMPLETED date: 2022-11-01 date: 2024-02-01 date: 2024-02-01 date: 2024-03-04 date: 2024-03-04 name: Celal Bayar University class... |
<|newrecord|> nctId: NCT06290687 id: CASE5824 briefTitle: Partial Cystectomy & Extended Pelvic Lymph Node Dissection With SOC Perioperative Systemic Therapy overallStatus: NOT_YET_RECRUITING date: 2024-08 date: 2026-01-29 date: 2027-01-29 date: 2024-03-04 date: 2024-03-06 name: Case Comprehensive Cancer Center class: O... |
<|newrecord|> nctId: NCT06290674 id: P.T.REC/012/004043 briefTitle: Extracorporeal Shockwave on Abdominal Adiposity and Lipid Profile overallStatus: COMPLETED date: 2022-09-11 date: 2024-01-01 date: 2024-02-01 date: 2024-03-04 date: 2024-03-07 name: Adly A Adam class: OTHER briefSummary: Almost postmenopausal women sto... |
<|newrecord|> nctId: NCT06290661 id: UHCT-IEC-SOP-016-03-01 briefTitle: Clinical Trial of the Safety and Efficacy of Peripheral Nerve Stimulation in the Treatment of Postherpetic Neuralgia. overallStatus: RECRUITING date: 2023-02-09 date: 2024-12-31 date: 2025-06-30 date: 2024-03-04 date: 2024-03-04 name: Wuhan Union H... |
1. The efficacy of percutaneous peripheral nerve stimulation in patients with postherpetic neuralgia |
2. The safety of percutaneous peripheral nerve stimulation in patients with postherpetic neuralgia Participants are going to undergo procedure that implant peripheral nerve stimulation electrode produced by Jiangsu CED Medtech Co., Ltd. Then the subjects, whose VAS scores decrease more 30% than baseline level, are clas... |
Researchers will compare pain scores between the two groups to see if peripheral nerve stimulation is effective to patients with postherpetic neuralgia. conditions: Neuropathic Pain conditions: Postherpetic Neuralgia studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose:... |
<|newrecord|> nctId: NCT06290648 id: 22-0868 id: 5R34MH130555 type: NIH link: https://reporter.nih.gov/quickSearch/5R34MH130555 briefTitle: Forging New Paths: Building Interventions to Treat Criminogenic Needs in Community Based Mental Health Settings acronym: FNP overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2... |
1. To examine the effectiveness of Forging New Paths at improving the primary study outcomes (aggression and community tenure). |
2. To test the ability of Forging New Paths to engage the study treatment targets (impulsivity and criminal attitudes) |
Participants will complete a screening interviews to see if they are eligible. Participants who are eligible will be randomly assigned to participate in one of two study conditions: Forging New Paths and usual care or usual care alone. All participants who are assigned to a study condition will participate in up to thr... |
<|newrecord|> nctId: NCT06290635 id: Pro00119668 briefTitle: Edmonton Dyspnea Inventory- Validation Study overallStatus: ACTIVE_NOT_RECRUITING date: 2022-11-11 date: 2024-05-30 date: 2024-12-30 date: 2024-03-04 date: 2024-04-11 name: University of Alberta class: OTHER briefSummary: Breathlessness is a common problem fo... |
<|newrecord|> nctId: NCT06290622 id: IRB300012414 (UAB23136) briefTitle: PD-1, LAG-3 and TIM-3 Checkpoint Blockade in DLBCL overallStatus: NOT_YET_RECRUITING date: 2024-06-30 date: 2026-06-30 date: 2028-01-31 date: 2024-03-04 date: 2024-04-24 name: University of Alabama at Birmingham class: OTHER briefSummary: This stu... |
<|newrecord|> nctId: NCT06290609 id: 72799 briefTitle: Vibrotactile Coordinated Reset for Spasticity After Spinal Cord Injury overallStatus: NOT_YET_RECRUITING date: 2024-03-15 date: 2024-06-15 date: 2024-06-15 date: 2024-03-04 date: 2024-03-04 name: Stanford University class: OTHER briefSummary: The purpose of our stu... |
<|newrecord|> nctId: NCT06290596 id: MSR/AZAST/AIP029/21/222/8/2023 briefTitle: Vasopressin Versus Tranexamic Acid for Control of Blood Loss Related to Abdominal Hysterectomy overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2024-10-01 date: 2024-10-01 date: 2024-03-04 date: 2024-03-06 name: Al-Azhar University ... |
<|newrecord|> nctId: NCT06290583 id: Prilocaine in cesarean section briefTitle: Comparing the Effect of Spinal Bupivacaine Versus Spinal Prilocaine on Maternal Blood Pressure in Cesarean Section overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-11 date: 2024-12 date: 2024-03-04 date: 2024-03-05 name: South Val... |
<|newrecord|> nctId: NCT06290570 id: 23-007685 briefTitle: A Study of Artificial Intelligence ECG With ECG Devices to Detect Hypertrophic Cardiomyopathy Distinct From Athlete's Heart overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-09 date: 2025-09 date: 2024-03-04 date: 2024-04-03 name: Mayo Clinic class: OT... |
<|newrecord|> nctId: NCT06290557 id: 2023-507737-17-00 briefTitle: First-in-man Single-dose and Multiple Dose Study to Evaluate the Safety, Tolerability and Efficacy ofHY-133 acronym: HY-133 overallStatus: NOT_YET_RECRUITING date: 2024-07-01 date: 2025-07-01 date: 2026-07-01 date: 2024-03-04 date: 2024-03-05 name: Univ... |
As innovative product HY-133 a recombinant chimeric bacteriophage endolysin will be sprayed in both nostrils of healthy subjects once or five times in one day. To avoid possible bias the subjects will be randomized 3:2 verum vs placebo, moreover the subject as well as the investigator will be blinded to the group assig... |
<|newrecord|> nctId: NCT06290544 id: CCM 1552 briefTitle: Cardiovascular Risk Assessment in a Cohort of Italian Patients With Type 1 Diabetes Mellitus (CARDT1) acronym: CARDT1 overallStatus: RECRUITING date: 2021-11-29 date: 2026-07 date: 2026-07 date: 2024-03-04 date: 2024-03-04 name: Centro Cardiologico Monzino class... |
<|newrecord|> nctId: NCT06290531 id: CEBD-CU-2023-11-12 briefTitle: Different Methods for Reducing Buccal Infiltration Local Anesthesia Injection Pain overallStatus: COMPLETED date: 2022-01-16 date: 2023-09-28 date: 2023-09-28 date: 2024-03-04 date: 2024-03-04 name: Cairo University class: OTHER briefSummary: Local ane... |
The introduction of the Buzzy device is considered a distraction measure in the medical field. Alanazi et al., 2019, studied the effect of using the Buzzy device with cold and vibration compared to the conventional infiltration technique using 30-gauge needle. They concluded that the use of the Buzzy device resulted in... |
Ballard et al., 2019, mentioned in their systematic review the efficacy of the Buzzy device for pain management during needle-related procedures, they concluded that the use of the device may be promising. Ghaderi et al., 2013, evaluated the effect of cooling the injection site on pain perception before infiltration of... |
<|newrecord|> nctId: NCT06290518 id: PROBIFERT P051 briefTitle: Modulation of Reproductive Microbiota by Ligilactobacillus Salivarius CECT5713 overallStatus: COMPLETED date: 2020-09-01 date: 2023-05-03 date: 2024-01-29 date: 2024-03-04 date: 2024-03-04 name: Biosearch S.A. class: INDUSTRY name: Hospital San Carlos, Mad... |
<|newrecord|> nctId: NCT06290505 id: PALEO briefTitle: A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study acronym: PALEO overallStatus: RECRUITING date: 2021-12-08 date: 2027-07-31 date: 2028-01-31 date: 2024-03-04 date: 2024-03-04 name: Australasian Gastro-Intestinal... |
<|newrecord|> nctId: NCT06290492 id: AHMU-tDCS-insomnia briefTitle: Clinical Efficacy and Mechanism of High Definition tDCS Based on dmPFC in the Intervention of Chronic Insomnia overallStatus: RECRUITING date: 2023-05-01 date: 2023-12-30 date: 2024-11-01 date: 2024-03-04 date: 2024-03-04 name: WANG KAI class: OTHER br... |
<|newrecord|> nctId: NCT06290479 id: 20358 briefTitle: A Three-Group Study to Examine the Efficacy of the Air up® Drinking System at Improving Hydration and Associated Health Outcomes overallStatus: RECRUITING date: 2024-02-15 date: 2024-06-30 date: 2024-06-30 date: 2024-03-04 date: 2024-03-04 name: air up GmbH class: ... |
<|newrecord|> nctId: NCT06290466 id: FCN-437c-CP-004 briefTitle: Clinical Study on Pharmacokinetics of FCN-437c Capsule and Its Effect on QT Interval in Healthy Subjects overallStatus: COMPLETED date: 2022-11-11 date: 2023-02-08 date: 2023-02-08 date: 2024-03-04 date: 2024-03-04 name: Ahon Pharmaceutical Co., Ltd. clas... |
This study plans to set up 2 dose groups, low-dose group 300mg and high-dose group 400mg.Nine healthy subjects were planned to be enrolled in each dose group, with a 2:1 ratio of placebo control. |
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