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Inclusion criteria: |
1. age ≥ 18 years of age |
2. indication for radiation treatment of a malignant disease |
3. Karnofsky Performance score (KPS) ≥ 70% |
4. Life expectancy ≥ 3 months |
Exclusion criteria: |
1. Inability to provide informed consent |
2. Inability to attend study visits and fulfill data collection requirements |
3. Simultaneous participation in other studies which could interfere with this study Primary outcome: Financial burden as expressed by the COST score, measured at baseline and 3 months after completion of radiotherapy |
Secondary outcomes: |
* Socio-Economic factors at baseline |
* Health-related quality of life (EORTC QLQ-C30) at baseline and 3 months |
* Depression (PHQ-9) at baseline and 3 months |
* Coping mechanisms to address financial burden |
Primary Endpoint: Influence of secondary outcomes on changes of the primary outcome (COST-Score) between baseline and 3 months. |
Secondary Endpoints: |
* Changes in the COST-Score over time |
* Changes in PHQ-9 over time |
* Changes in EORTC QLQ-C30 over time |
This is an exploratory pilot study. To assess the compliance and effectiveness of the used methods all patients willing to participate in the given time period will be enrolled. |
To be assessed for eligibility: n = 300 To be allocated/randomised (if applicable) to trial: n = 150 To be analysed: n = 120 conditions: Financial Toxicity studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 225 type: ESTIMATED name: Questionnaire measure: Financial Toxicity measure:... |
<|newrecord|> nctId: NCT06278818 id: MNESYS-PE0000006 briefTitle: Effects of Telerehabilitation on Brain Network Connectivity overallStatus: RECRUITING date: 2023-12-07 date: 2024-06-07 date: 2026-03-01 date: 2024-02-26 date: 2024-02-26 name: University of Pavia class: OTHER name: University of Parma name: University o... |
This longitudinal and multicenter study applies innovative cognitive telerehabilitation (TR) methods and evaluates their impact on functional parameters obtained with high-density electroencephalogram (HD-EEG) and resting-state functional magnetic resonance imaging (rsFMRI). The goal is to identify neurophysiological c... |
The study aims to: |
* Identify correlations between improvement in cognitive performance and functional brain data. |
* Use acquired knowledge to develop neurologically guided TR approaches for broader use. |
The research will include patients diagnosed with MCI associated with neurodegenerative diseases. Primary outcome measures include changes in resting-state brain connectivity assessed through HD-EEG and rsFMRI. Secondary outcomes involve the assessment of changes in neuropsychological measures, caregiver burden, immedi... |
The study is designed to last 30 months, with follow-up assessments at three time points. The primary outcomes will be evaluated using rsFMRI and HD-EEG instrumental acquisitions, the secondary outcomes will be evaluated using clinical assessments and neuropsychological tests. conditions: Mild Cognitive Impairment stud... |
<|newrecord|> nctId: NCT06278805 id: ayk22 briefTitle: Adaptation and Validation of the LUNS for Use in Turkey. overallStatus: RECRUITING date: 2024-03-01 date: 2024-12-01 date: 2025-02-01 date: 2024-02-26 date: 2024-04-11 name: Uşak University class: OTHER name: Ankara University name: Istanbul University briefSummary... |
Our hypothesis in this study is: |
- The Turkish Longer-term Unmet Needs after Stroke Questionnaire (T-LUNS) is a valid tool for assessing the unmet needs of stroke patients in the Turkish population. conditions: Stroke conditions: Disability Physical conditions: Quality of Life studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: CROSS_... |
<|newrecord|> nctId: NCT06278792 id: Z-2021104 briefTitle: Readily Available Urinary Sodium Analysis in Patients With Acute Decompensated Heart Failure acronym: EASY-HF overallStatus: COMPLETED date: 2022-03-07 date: 2023-07-12 date: 2024-01-05 date: 2024-02-26 date: 2024-02-26 name: Ziekenhuis Oost-Limburg class: OTHE... |
* difference in natriuresis and diuresis |
* feasibility of the protocol. |
Participants will be asked to gather two 24 h urine collections. |
Researchers will compare SOC versus nurse-led diuretic titration to see if there is a difference in natriuresis after 48 hours. conditions: Acute Decompensated Heart Failure studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The EASY-HF study was a sing... |
<|newrecord|> nctId: NCT06278779 id: X23-0311 briefTitle: Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression acronym: TREK overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2027-04 date: 2027-04 date: 2024-02-26 date: 2024-03-13 name: The George Institute class: OTHER name: ... |
* How the two formulations compare in terms of their effectiveness in treating TRD. |
* How the two formulations compare in their acceptability to patients, safety, effects on patient quality of life and function, and cost effectiveness. |
Participants will be randomised to receive either Spravato® or racemic ketamine treatment and asked to complete some questionnaires to assess the effects on mood, treatment acceptability, side effects, quality of life and function, and health economic outcomes. conditions: Treatment Resistant Depression studyType: INTE... |
<|newrecord|> nctId: NCT06278766 id: M24-416 briefTitle: A Study to Assess the Mass Balance of [14C] ABBV-552 in Healthy Male Participants Following Single Oral Dose Administration overallStatus: COMPLETED date: 2024-02-21 date: 2024-04-19 date: 2024-04-19 date: 2024-02-26 date: 2024-04-29 name: AbbVie class: INDUSTRY ... |
<|newrecord|> nctId: NCT06278753 id: 2025/05/02 briefTitle: Comparison of Standard Cystoscopy With Carbon Dioxide Cystoscopy overallStatus: RECRUITING date: 2021-07-01 date: 2024-03-01 date: 2024-04-01 date: 2024-02-26 date: 2024-02-26 name: Tepecik Training and Research Hospital class: OTHER briefSummary: For the eval... |
<|newrecord|> nctId: NCT06278740 id: SCIUSG24 briefTitle: Upper Extremity Pathologies in Spinal Cord Injuries overallStatus: NOT_YET_RECRUITING date: 2024-02-26 date: 2025-02-26 date: 2025-03-26 date: 2024-02-26 date: 2024-02-26 name: Afyonkarahisar Health Sciences University class: OTHER briefSummary: This study aims ... |
<|newrecord|> nctId: NCT06278727 id: SYSKY-2023-1173-01 briefTitle: Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical Therapy overallStatus: RECRUITING date: 2024-01-01 date: 2025-06-01 date: 2025-12-31 date: 202... |
<|newrecord|> nctId: NCT06278714 id: 0012 briefTitle: Influence of an Inspiratory Muscle Fatigue Protocol on Healthy Youngs on Respiratory Muscle Strength and Heart Rate Variability overallStatus: NOT_YET_RECRUITING date: 2024-03-04 date: 2024-03-11 date: 2024-03-20 date: 2024-02-26 date: 2024-02-26 name: Sierra Varona... |
According to our hypothesis, the execution of a protocol inducing inspiratory muscle fatigue in healthy youngs could influence cardiorespiratory function. |
In this study, subjects will be divided into three groups: the experimental group , the activation group and the control group. |
Measurements of variables, such as maximal inspiratory pressure, heart rate variability and diaphragmatic strength (ultrasound image), will be conducted. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT masking: DOUBLE maskingDescripti... |
<|newrecord|> nctId: NCT06278701 id: 2024-003-01 briefTitle: The Effect of Late-evening Snacks on Patients With Primary Hepatocellular Carcinoma After Hepatectomy overallStatus: ACTIVE_NOT_RECRUITING date: 2023-11-01 date: 2025-01-31 date: 2025-07-30 date: 2024-02-26 date: 2024-02-26 name: DU Yao class: OTHER briefSumm... |
The goal of this clinical trial is to learn about the effects of late-evening snacks on health conditions of hepatocellular carcinoma patients who underwent hepatectomy, and to further explore the effects of late-evening snacks on patients' metabolic patterns. The main question it aims to answer are: • the effect of la... |
* the effect of late-evening snacks on the recovery of liver function in liver cancer hepatectomy patients; |
* the effect of late-evening snacks on the complication rate of hepatic resection patients with hepatocellular carcinoma; |
* the effect of late-evening snacks on long-term quality of life of hepatic resection patients with hepatocellular carcinoma; |
* the effect of late-evening snacks on the metabolic pattern of hepatic resection patients with hepatocellular carcinoma. |
After learning about the 2 dietary modalities of the late-evening snacks and regular diet, patients will be placed in the different groups according to your preference. Patients who enter the test group will have additional meal 1h before bedtime every day, while patients in the control group will have normal diet. Pat... |
* eat 1h before bedtime; |
* follow the doctor's instructions during their stay in the hospital; |
* have follow-up examinations at 1 month, 3 months and 6 months after the operation, after which blood samples will be collected for metabolite testing. conditions: Liver Neoplasms studyType: INTERVENTIONAL phases: NA allocation: NON_RANDOMIZED interventionModel: PARALLEL interventionModelDescription: This study utiliz... |
<|newrecord|> nctId: NCT06278688 id: 112R10438Y briefTitle: Precision Probiotic Supplementation in Individuals With Mild Cognitive Impairment overallStatus: NOT_YET_RECRUITING date: 2024-03-18 date: 2025-07-31 date: 2027-07-31 date: 2024-02-26 date: 2024-02-26 name: National Yang Ming University class: OTHER name: Nati... |
Aim 1: To investigate the association between gut microbiota, MCI and AD biomarkers. Investigators plan to compare gut microbiota profiles in a well-characterized cohort between individuals with MCI and cognitively normal adults using metagenomics sequencing data. Also, the relationship between gut microbiota and AD bi... |
Aim 2: To determine the efficacy of precision probiotic supplementation on cognitive decline (primary outcome) and functional brain changes (secondary outcome) in individuals with MCI due to AD using a randomized, double-blind, placebo-controlled trial. Investigators plan to recruit 120 individuals with MCI due to AD, ... |
Aim 3: To investigate potential mediators underlying the effect of probiotic supplementation. The most apparent mediator will be a shift or changes in gut microbiota. Other potential mediators will be related to decreased lipopolysaccharide, proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interle... |
<|newrecord|> nctId: NCT06278675 id: SEOVA briefTitle: Multiple Study of Electroaccpuncture in ARDS overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2026-06-30 date: 2026-12-31 date: 2024-02-26 date: 2024-04-23 name: Nanjing University of Traditional Chinese Medicine class: OTHER briefSummary: In order to clari... |
<|newrecord|> nctId: NCT06278662 id: CIRCUS cmRCT briefTitle: Cohort Multiple Randomized Controlled Trial in Pediatric Asthma acronym: CIRCUS overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2034-04-01 date: 2034-04-01 date: 2024-02-26 date: 2024-02-26 name: Mattienne van der Kamp class: OTHER briefSummary: The... |
Primary Objectives within cmRCT cohort: |
* Provide a framework for multiple randomized (eHealth) interventions for asthmatic children |
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