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This study is conducted according to the principles of the Declaration of Helsinki regarding experimentation involving human subjects, and written informed consent will be obtained from all participants before enrollment. conditions: Anxiety conditions: Pancreatic Cancer conditions: Pancreatic Cystic Lesions conditions... |
<|newrecord|> nctId: NCT06268093 id: XWTETS briefTitle: The Therapeutic Effect of Thalidomide in Syringomyelia overallStatus: RECRUITING date: 2024-02 date: 2027-02 date: 2028-02 date: 2024-02-20 date: 2024-02-20 name: Xuanwu Hospital, Beijing class: OTHER briefSummary: Purpose: This phase II clinical trial aims to eva... |
Primary outcome measure: The primary endpoint is the change of ASIA at week 12. The clinical efficacy is defined as ASIA increase ≥ 1 at week 12, as compared with that before thalidomide usage. conditions: Syringomyelia conditions: Thalidomide studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: S... |
<|newrecord|> nctId: NCT06268080 id: A+9317 briefTitle: Depth of Anesthesia on Postoperative Delirium and Cognitive After Surgery acronym: Balanced-2 overallStatus: NOT_YET_RECRUITING date: 2024-03-31 date: 2027-12-31 date: 2028-12-31 date: 2024-02-20 date: 2024-02-20 name: Auckland City Hospital class: OTHER_GOV brief... |
Delirium is the most common serious surgical complication, occurring in an estimated one in four older adults undergoing major surgery. Delirium causes significant distress to patients and family, and is associated with prolonged hospital stay, physical disability, progression to dementia-like illnesses, and discharge ... |
Older adults (aged ≥65 years, or Indigenous, Pasific patients aged ≥55 years) undergoing major surgery with general anesthesia (excluding heart and brain surgery) and able to provide consent will be able to participate. Participants will be randomized to two groups - a lighter general anesthesia group and a deeper gene... |
If found to be effect, this simple, cheap, and widely available treatment could reduce disability, preserve brain health and wellbeing of many older adults undergoing surgery worldwide, and save millions in healthcare dollars. conditions: Delirium, Postoperative conditions: Anesthesia conditions: Surgery-Complications ... |
<|newrecord|> nctId: NCT06268067 id: Renal uptake at F18 FDG PET/CT briefTitle: Kidney Uptake at F-18 FDG PET/CT Studies and Renal Function Status overallStatus: NOT_YET_RECRUITING date: 2024-03-01 date: 2025-03-01 date: 2025-04-01 date: 2024-02-20 date: 2024-02-20 name: Assiut University class: OTHER briefSummary: Sea... |
<|newrecord|> nctId: NCT06268054 id: DEH113-III-0123 briefTitle: Efficacy and Safety of DEH113 in the Treatment of Menstrual Cramp Pain Associated With Primary Dysmenorrhea acronym: LIBERTÀ overallStatus: NOT_YET_RECRUITING date: 2025-02 date: 2027-02 date: 2027-09 date: 2024-02-20 date: 2024-02-22 name: EMS class: IND... |
<|newrecord|> nctId: NCT06268041 id: 427659 id: R01HD093694 type: NIH link: https://reporter.nih.gov/quickSearch/R01HD093694 briefTitle: HIT-Stroke Trial 2 acronym: HST2 overallStatus: RECRUITING date: 2024-02-09 date: 2028-01 date: 2028-04 date: 2024-02-20 date: 2024-02-20 name: University of Cincinnati class: OTHER n... |
<|newrecord|> nctId: NCT06268028 id: BELMA TA briefTitle: Discharge Training Given to Primiparous Mothers Who Had a Cesarean Delivery overallStatus: ENROLLING_BY_INVITATION date: 2024-01-10 date: 2024-06-10 date: 2024-11-10 date: 2024-02-20 date: 2024-02-21 name: Aydin Adnan Menderes University class: OTHER briefSummar... |
The research is a pre-test-post-test, randomized controlled experimental study. conditions: Education studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: OTHER masking: SINGLE whoMasked: PARTICIPANT count: 70 type: ESTIMATED name: Training measure: A pre-test will be ... |
<|newrecord|> nctId: NCT06268015 id: Pro00115311 briefTitle: Botensilimab and Balstilimab Optimization in Colorectal Cancer acronym: BBOpCo overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2028-07 date: 2028-07 date: 2024-02-20 date: 2024-02-22 name: Nicholas DeVito, MD class: OTHER name: Gateway for Cancer Resear... |
<|newrecord|> nctId: NCT06268002 id: 5876557033 briefTitle: Effect of Vernonia Cinerea Lozenges as a Smoking Cessation Aid in Patients With Non-communicable Diseases overallStatus: COMPLETED date: 2017-09-01 date: 2021-09-30 date: 2021-12-31 date: 2024-02-20 date: 2024-02-28 name: Chulalongkorn University class: OTHER ... |
<|newrecord|> nctId: NCT06267989 id: Gothenburg University briefTitle: The Effectiveness of Early Intervention to Correct the Position of PDC:s acronym: PDC overallStatus: RECRUITING date: 2024-02-12 date: 2027-12-30 date: 2027-12-30 date: 2024-02-20 date: 2024-02-21 name: Region Örebro County class: OTHER briefSummary... |
It has been suggested that if the primary ('baby' or 'milk') canine is extracted at an appropriate time in a child with a suspected palatally displaced canine, then the displaced tooth might spontaneously correct its position (Ericson and Kurol, 1988b) and the extraction of the baby canine when a clinician suspects tha... |
Other authors have suggested that using a RME (Rapid Maxillary expansion) or headgrear (EOT) to create sufficient space within the dental arch for the permanent canine tooth will encourage the tooth to erupt (Baccetti et al., 2011). This approach might be less traumatic to a child who may have had no experience of dent... |
<|newrecord|> nctId: NCT06267976 id: REB23-1003 briefTitle: Validation of the ProSomnus® RPMO2 Device overallStatus: NOT_YET_RECRUITING date: 2024-04-10 date: 2024-05-31 date: 2024-06-30 date: 2024-02-20 date: 2024-04-02 name: ProSomnus Sleep Technologies class: INDUSTRY briefSummary: The purpose of the study is to: |
1. Evaluate the SpO2 accuracy of the oximeter component of the ProSomnus RPMO2 Device during non-motion conditions over the range of 70-100% SaO2 by comparison to SaO2 values determined by arterial blood sample specimen analyzed by a CO-oximeter. |
2. Evaluate the pulse rate performance simultaneously collected over the SpO2 range. conditions: Healthy studyType: OBSERVATIONAL observationalModel: COHORT timePerspective: PROSPECTIVE count: 15 type: ESTIMATED name: ProSomnus RPMO2 measure: SpO2 accuracy measure: Pulse rate accuracy sex: ALL minimumAge: 18 Years maxi... |
<|newrecord|> nctId: NCT06267963 id: C4391010 id: 2023-507074-40-00 type: REGISTRY domain: CTIS (EU) briefTitle: A Study to Understand What the Body Does to the Study Medicine Called PF-07220060 When Taken by Healthy Adults overallStatus: ACTIVE_NOT_RECRUITING date: 2024-01-31 date: 2024-04-18 date: 2024-04-18 date: 20... |
The study is seeking for participants who: |
* are males aged 18 to 65 years and are healthy. |
* have Body mass index (BMI) between 17.5 and 30.5 kilograms/meter2 |
* have a total body weight of at least 50 kilograms. |
The study consists of two groups. In group 1, participants will take one amount of PF-07220060 by mouth. In group 2, participants will take one amount by mouth and one amount as an injection through a vein at the study clinic. |
In group 1, participants will stay at the clinic site for up to 15 days. In group 2, the duration of participants' stay depends on the results of group 1. |
During their stays, participants will have their blood, urine, and feces collected by the study doctors several times. We will measure the level of PF-07220060 in participants' blood, urine, and feces samples. This will help to know how much the study medicine is getting taken up by the body. At the end of the study, p... |
<|newrecord|> nctId: NCT06267950 id: PILUO-INFANT briefTitle: Effect of Oral Feeding in Infants With Pierre Robin Syndrome overallStatus: RECRUITING date: 2024-02-29 date: 2024-10 date: 2024-10 date: 2024-02-20 date: 2024-03-06 name: Zeng Changhao class: OTHER briefSummary: This was a randomized controlled study. The i... |
<|newrecord|> nctId: NCT06267937 id: 101 briefTitle: Hip Fractures in Chile: Implications for Public Health Policy and Healthcare Delivery overallStatus: COMPLETED date: 2023-03-10 date: 2023-03-10 date: 2024-01-30 date: 2024-02-20 date: 2024-02-20 name: University of Chile class: OTHER name: Instituto Sistemas Complej... |
<|newrecord|> nctId: NCT06267924 id: Olith10703 briefTitle: SENSE-VM: Safety and Effectiveness of a Novel Medical Device for Symptom Ease in Vestibular Migraines overallStatus: ENROLLING_BY_INVITATION date: 2024-02-28 date: 2024-08-31 date: 2024-09-30 date: 2024-02-20 date: 2024-03-19 name: Otolith Labs class: INDUSTRY... |
Participants will be: |
* Enrolled up to 50 days; enrollment, 14 days in Baseline Phase (no device), 7 days in Transition Phase, 28 days in Treatment Phase (study device) |
* Randomized and stratified into groups based on the referring clinic to be assigned one study device |
* Asked to use the study device as instructed by the study coordinator |
* Asked to submit daily diaries reporting their symptoms and use of device, and to participate in tele-health visits with study coordinators |
* Asked to provide their vertigo diagnosis from their physician |
* Compensated for their participation |
Researchers will compare the randomized groups to determine which group responds better to which device. conditions: Vestibular Migraine conditions: Migraine Associated Vertigo studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: The proposed clinical tri... |
<|newrecord|> nctId: NCT06267911 id: 202223-10 id: 160/U/2022 type: OTHER_GRANT domain: Fundació La Marató de TV3 briefTitle: Rehabilitation Gaming System for Intensive Care Units acronym: RGS-ICU overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2026-04 date: 2026-04 date: 2024-02-20 date: 2024-04-23 name: Univers... |
This trial aims to evaluate the efficacy of an innovative neuropsychological e-health intervention for early cognitive stimulation and psychological support of people in critical care, i.e. the Rehabilitation Gaming System for Intensive Care Units (RGS-ICU) intervention, in improving comfort during ICU admission and co... |
The investigadors hypothesize that the cognitive stimulation and psychological support protocols of the RGS-ICU intervention, applied as an adjunct to standard ICU care, in addition to being safe for people in critical care units, will improve comfort during ICU admission and cognitive and mental health outcomes after ... |
The findings derived from this trial may contribute to establish a novel and superior paradigm of human-centered ICU care to improve the comfort of people admitted to the ICU. This achievement could also have a relevant impact on medical and economic costs during ICU admission, and on functionality and health-related q... |
The RGS-ICU intervention has been designed at Corporacion Parc Taulí with the collaboration of the University of the Balearic Islands and has been developed by Eodyne Systems S.L., a company dedicated to the development of science-based technological solutions for intervention, monitoring, diagnosis, and prognosis in s... |
<|newrecord|> nctId: NCT06267898 id: EBMT- 842205547 briefTitle: Non Interventional Study on Iron Toxicity After First Allo-transplant in MDS/CMML overallStatus: COMPLETED date: 2009-11-01 date: 2015-01-29 date: 2015-05-21 date: 2024-02-20 date: 2024-02-20 name: European Society for Blood and Marrow Transplantation cla... |
Toxic effects of iron may play an important role in the complications associated with HSCT. Iron chelation therapy may reduce the acute and chronic treatment-related toxicity by removing excess of iron, iron radicals and reactive oxygen species (ROS). |
There is little information about the efficacy and safety of iron chelation in MDS patients. This audit wants to evaluate the effect of iron toxicity on treatment-related mortality in untreated, adult MDS or CMML patients during and after treatment with myeloablative conditioning (MAC) and reduced intensity conditionin... |
<|newrecord|> nctId: NCT06267885 id: Children NOF fracture fixation briefTitle: Fixation of Fracture Neck of Femur in Children overallStatus: NOT_YET_RECRUITING date: 2024-03 date: 2026-02 date: 2026-03 date: 2024-02-20 date: 2024-02-20 name: Assiut University class: OTHER briefSummary: Find the best way for fixation o... |
<|newrecord|> nctId: NCT06267872 id: HVTN 309 briefTitle: A Clinical Trial in Adult Participants Without HIV and in Overall Good Health to Evaluate the Safety and Immunogenicity of CD4BS CH505M5 Pr-NP1 Followed by CH505 TF chTrimer Boost Both Adjuvanted With Either Lipid Nanoparticles (LNPs) or 3M-052-AF + Alum overall... |
About 42 people will take part in the HVTN 309 clinical trial. This clinical trial will take place at multiple sites in the US and South Africa and the clinical trial is divided into 3 parts: Part A, Part B and Part C. About 3 people will participate in Part A of this study. After results from Part A are reviewed, it w... |
<|newrecord|> nctId: NCT06267859 id: No. 2 of 2023/11/7 briefTitle: Development of Methods for Effective Treatment and Improvement of Common Somatic Diseases in Children overallStatus: RECRUITING date: 2023-11-08 date: 2033-12-30 date: 2034-01-30 date: 2024-02-20 date: 2024-02-28 name: Tashkent Pediatric Medical Instit... |
The main questions it aims to answer: |
* Analysis of common congenital diseases among children; |
* Analysis of commonly diagnosed bronchopulmonary and cardiovascular diseases among children; |
* Based on the results of the primary research, common diseases among children will be identified; |
* Analysis of existing treatment methods and their effectiveness; |
* Development of modern methods of treatment and rehabilitation of children. conditions: Respiratory Diseases conditions: Congenital Heart Defects studyType: INTERVENTIONAL phases: EARLY_PHASE1 allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: identification of children from the group of ... |
<|newrecord|> nctId: NCT06267846 id: NBI-1070770-MDD2029 briefTitle: A Study to Evaluate the Efficacy and Safety of NBI-1070770 in Adults With Major Depressive Disorder overallStatus: RECRUITING date: 2024-03-20 date: 2025-09 date: 2025-12 date: 2024-02-20 date: 2024-04-12 name: Neurocrine Biosciences class: INDUSTRY b... |
<|newrecord|> nctId: NCT06267833 id: MSKUSBFFTR01 briefTitle: The Effect of Trunk and Upper Extremity Exercises Added to the Otago Exercise Program acronym: Otago Exercise overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2026-01-01 date: 2026-06-01 date: 2024-02-20 date: 2024-02-20 name: Muğla Sıtkı Koçman Univ... |
<|newrecord|> nctId: NCT06267820 id: 2010 briefTitle: Postoperative Pain Control by Adding Ketorolac to Bupivacaine in Transversus Abdominis Plane Block in Children overallStatus: COMPLETED date: 2023-06-01 date: 2023-12-01 date: 2023-12-10 date: 2024-02-20 date: 2024-02-20 name: Sohag University class: OTHER briefSumm... |
Ketorolac has analgesic effect comparable to morphine. Children were arranged randomly into two equal groups, forty-five children in each. |
Group (K) (n= 45): received ultrasound guided TAP block with bupivacaine 0.25% (0.5 ml/kg) and ketorolac (0.5 mg/kg). |
Group (T) (n =45): received ultrasound guided TAP block with bupivacaine 0.25% (0.5 ml/kg) conditions: Postoperative Pain, Acute studyType: INTERVENTIONAL phases: PHASE2 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: HEALTH_SERVICES_RESEARCH masking: QUADRUPLE whoMasked: PARTICIPANT whoMasked: CARE_... |
<|newrecord|> nctId: NCT06267807 id: 114369 id: NL84520.091.23 type: OTHER domain: Protocol ID METC briefTitle: Lymphatic Phenotype in Noonan Syndrome Spectrum Disorders acronym: LENS overallStatus: RECRUITING date: 2024-03-27 date: 2025-03-13 date: 2025-06-01 date: 2024-02-20 date: 2024-02-20 name: Radboud University ... |
<|newrecord|> nctId: NCT06267794 id: ODISEA Study briefTitle: Prolonged Release Pirfenidone Versus Placebo in Compensated Cirrhosis. acronym: ODISEA overallStatus: COMPLETED date: 2015-06-26 date: 2021-12-30 date: 2023-03-24 date: 2024-02-20 date: 2024-02-20 name: Jorge L Poo class: OTHER briefSummary: This will be a m... |
Methods to assign treatment: |
Before assigning numbers to subjects, the researcher must confirm that the inclusion criteria have been met, that none of the exclusion criteria apply, that written and signed informed consent has been obtained, that the evaluations of the scrutiny (of admission) and that the required laboratory results are available a... |
The person responsible for the medication at the research site will contact the Randomization center, where the treatment will be assigned to the patient. whoMasked: PARTICIPANT whoMasked: CARE_PROVIDER whoMasked: INVESTIGATOR count: 180 type: ACTUAL name: Pirfenidone 1200 mg name: Pirfenidone 1800 mg name: Placebo mea... |
<|newrecord|> nctId: NCT06267781 id: TRANSPLANT-PRO briefTitle: RRMS: Disease PROgression and Myeloid Profiling After Bone Marrow TRANSPLANTation and Second Line Therapies acronym: TRANSPLANTPRO overallStatus: RECRUITING date: 2022-09-02 date: 2027-09-02 date: 2027-09-02 date: 2024-02-20 date: 2024-02-20 name: IRCCS Sa... |
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