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<|newrecord|> nctId: NCT06388070 id: HUC3-053 briefTitle: To Evaluate the Efficacy and Safety of HUC3-053 in Patients With Dry Eye Syndrome overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-03 date: 2025-04 date: 2024-04-29 date: 2024-04-29 name: Huons Co., Ltd. class: INDUSTRY briefSummary: This is a multi-ce... |
After a 2-week run-in period, patients will be randomized equally to the HUC3-053 or Hyalein Mini Drops administered bilaterally five to six times a day for 12 weeks. conditions: Dry Eye Syndromes studyType: INTERVENTIONAL phases: PHASE3 allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose: TREATMENT maski... |
<|newrecord|> nctId: NCT06388057 id: 5836 briefTitle: Intraoperative Ultrasound in Crohn's Disease overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-06-30 date: 2025-09-01 date: 2024-04-29 date: 2024-04-29 name: Fondazione Policlinico Universitario Agostino Gemelli IRCCS class: OTHER briefSummary: To study ... |
<|newrecord|> nctId: NCT06388044 id: PRO00115010 briefTitle: ACT for Infertility: Case Series overallStatus: NOT_YET_RECRUITING date: 2024-04 date: 2025-04 date: 2025-04 date: 2024-04-29 date: 2024-04-29 name: Duke University class: OTHER briefSummary: In the United States, around 19% of reproductive-aged couples suffe... |
<|newrecord|> nctId: NCT06388031 id: CAPTRAL2024v1 briefTitle: ICI Rechallenge for Advanced NSCLC With Long-Term Response to First-Line ICI overallStatus: NOT_YET_RECRUITING date: 2024-05-10 date: 2027-01-10 date: 2027-12-10 date: 2024-04-29 date: 2024-04-29 name: Peking Union Medical College Hospital class: OTHER brie... |
This study aims to evaluate efficacy and safety of ICI rechallenge in long-term responders to prior ICI. Furthermore, it seeks to identify biomarkers capable of predicting the efficacy of immunotherapy and prognosis. conditions: Non-small Cell Lung Cancer studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interven... |
<|newrecord|> nctId: NCT06388018 id: NRG-GY032 id: NCI-2023-09355 type: REGISTRY domain: CTRP id: CCTG EN.10 type: OTHER domain: CCTG id: U10CA180868 type: NIH link: https://reporter.nih.gov/quickSearch/U10CA180868 briefTitle: Tailoring Therapy in Post-surgical Patients With Low-risk Endometrial Cancer overallStatus: S... |
<|newrecord|> nctId: NCT06388005 id: 2021-060 briefTitle: The Application of Emotion Release Technology in Anxiety Patients Before Daytime Thyroid Surgery overallStatus: COMPLETED date: 2022-03-01 date: 2022-07-31 date: 2022-07-31 date: 2024-04-29 date: 2024-04-29 name: Yantai Yuhuangding Hospital class: OTHER briefSum... |
1 Data collection and evaluation tools |
1. The general data record sheet was self-designed by the research team, and the collected content included age, gender, BMI, occupation, general family status, economic situation, history of hypertension and cardiovascular diseases, history of anxiety and depression, self-rating anxiety scale (SAS) score, blood pressu... |
2. The anxiety was self-scored using the VAS-A (0-10 points), with 0 point as no anxiety and 10 as severe anxiety. |
3. Negative emotional intensity was scored using the subjective unit of disturbance scale (SUDS, 0-10 points), with 0 point as no and 10 points as severe. |
4. Nursing satisfaction was scored by the self-designed questionnaire (1-5 points): 5 points, very satisfied; 4 points, relatively satisfied; 3 points, satisfied; 2 points, medium; 1 point, dissatisfied. |
2 Intervention method of the control group The control group was given routine nursing. After entering the pre-anesthesia room, the patients were scored using the VAS-A, and those with VAS-A score ≥ 5 were considered to meet the inclusion criteria. After identity authentication, the preoperative precautions and reasons... |
3 Intervention method of the experimental group 3.1 Researcher training Before intervention, 4 nurses were trained for 5 d by a nurse with EFT qualification certificate, 1 h per day. The training content included: theoretical knowledge of EFT, tapping techniques, etc. After training, two assessments were conducted. Onl... |
3.2 Operating instructions The acupoint diagram was distributed to the experimental group by nurses, and the essentials and precautions of acupoint tapping were explained. The nurses demonstrated and tapped the acupoints on the patients while explaining, and then instructed them to tap on their own until they were able... |
3.3 Intervention content After routine nursing, the patients received EFT intervention. In addition, subjective anxiety was scored, blood pressure and heart rate were monitored, and nursing satisfaction was surveyed after admission and intervention. The specific methods are as follows. |
1. Preparation stage The patients with VAS-A score ≥ 5 meeting the inclusion criteria were in a comfortable position with eyes closed, and adopted breathing exercise to relax their whole body. The patients were guided to summarize the main current distresses, such as fear, tension, pain, surgical prognosis, economic bu... |
2. Tapping stage The patients were guided to gently massage the sore points on both sides of the body (2-3 fingers below the midpoint of the clavicle) with their five fingers together in a clockwise direction, while silently reciting the prompt 3 times. Then, the patients were guided to close their index and middle fin... |
3. Feedback stage After tapping, the patients communicated with the nurses at least once about their evaluated negative emotional intensity score and whether the score was accepted. If the tapping effect was not obvious, the evaluation was conducted by nurses, and the patients were guided to massage the sore points whi... |
<|newrecord|> nctId: NCT06387992 id: PP24023 briefTitle: Evaluation of the Agreement Between a Consultation With a Nurse Acquiring Three-dimensional Intraoral Images Made With a 3D Intraoral Camera and the Standard Consultation With a Dental Surgeon, in Institutionalized Elderly Subjects acronym: GEROdonto3D overallSta... |
Agreement on the results between the interpretation of the 3D images acquired by a nurse and the standard consultation by a dental surgeon could lead, in the long term, to a significant step forward in dental care of institutionalized patients. |
Indeed, training nursing home nurses to acquire 3D dental images would enable the identification of patients in need of immediate dental care and thus extend the possibilities of access to consultations with a dentist for these patients. This would increase the efficiency of care. conditions: Dental Care for Institutio... |
<|newrecord|> nctId: NCT06387979 id: 19-010725 id: NCI-2024-01000 type: REGISTRY domain: CTRP (Clinical Trial Reporting Program) id: 19-010725 type: OTHER domain: Mayo Clinic in Florida id: P30CA015083 type: NIH link: https://reporter.nih.gov/quickSearch/P30CA015083 id: R33CA240181 type: NIH link: https://reporter.nih.... |
<|newrecord|> nctId: NCT06387966 id: H-FNTN-PI-Ia briefTitle: A Randomized, Double-blind,Dose-escalating, Single-dose, Oral Phase I Clinical Study of Flunotinib Healthy People overallStatus: RECRUITING date: 2024-02-29 date: 2024-08-29 date: 2024-12-30 date: 2024-04-29 date: 2024-04-29 name: Chengdu Zenitar Biomedical ... |
<|newrecord|> nctId: NCT06387953 id: STUDY00019480 briefTitle: Mitigation of Emergence Agitation Through Implementation of Masimo Bridge Therapy overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-06 date: 2025-06 date: 2024-04-29 date: 2024-04-29 name: University of Washington class: OTHER briefSummary: This is... |
Primary Objective: Activation of Bridge Therapy from the time of the pre incision "time out" until 24 hours after admission to the PACU (Post Anesthesia Care Unit) is associated with reduced frequency and intensity of emergence agitation. |
Secondary Objective: Bridge Therapy activation will also result in a lower incidence of rescue pharmacologic treatment of agitation. |
Tertiary Objective: Activation of Bridge Therapy during a stable anesthetic state is associated with a reduced Patient State Index as measured on Sedline conditions: Emergence Delirium conditions: Agitation, Emergence studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL primaryPurpose... |
<|newrecord|> nctId: NCT06387940 id: UEC 2019 008 FHMS briefTitle: Acute Metabolic Effects of Carbohydrate Restriction at Varying Energy Levels overallStatus: COMPLETED date: 2019-11-05 date: 2020-04-01 date: 2022-11-20 date: 2024-04-29 date: 2024-04-29 name: University of Surrey class: OTHER briefSummary: This study i... |
<|newrecord|> nctId: NCT06387927 id: PT-NEUR-10/2023-520 briefTitle: Effect of Home-exercise Programs Versus Supervised Core Stability Exercises on Hypertensive Patient With Low Back Pain overallStatus: COMPLETED date: 2023-09-02 date: 2024-02-02 date: 2024-02-20 date: 2024-04-29 date: 2024-04-29 name: Ahram Canadian U... |
<|newrecord|> nctId: NCT06387914 id: PID 16707 id: 23/WM/0219 type: OTHER domain: Ethics Committee (South Birmingham REC) UK briefTitle: Efficacy of Pain Intervention With Deep Brain Stimulation Neuromodulation acronym: EPIONE overallStatus: NOT_YET_RECRUITING date: 2024-05-02 date: 2026-05-02 date: 2027-05-02 date: 20... |
* Does DBS lower the pain score in these participants. |
* What medical problems do participants have when having DBS? Researchers will compare different settings, to see if DBS works to treat severe post stroke pain. |
Participants will: |
* Undergo baseline screening procedures and have an MRI scan. |
* Have neurosurgery to put the DBS system in |
* Have follow up for 10 months |
* Visit the clinic at least 5 times in the study for check-ups and tests |
* Fill in questionnaires about pain and mood and have check ups remotely conditions: Central Post Stroke Pain studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: CROSSOVER interventionModelDescription: Double-blind trial, within subject randomisation and cross-over. primaryPurpose: TREATMENT ... |
Pseudo-ON =high frequency, low amplitude stimulation. Frequency up to 250 Hertz(Hz), Amplitude less than 0.5 milliamps(mA), Pulse Width 500 microseconds(uS). whoMasked: PARTICIPANT whoMasked: INVESTIGATOR whoMasked: OUTCOMES_ASSESSOR count: 30 type: ESTIMATED name: Stimulation ON name: Stimulation Pseudo-ON measure: Mc... |
<|newrecord|> nctId: NCT06387901 id: PABTOX - part 1 briefTitle: Investigating Paclitaxel Toxicity in Breast Cancer: The Roles of Physical Activity and Body Composition. acronym: PABTOX overallStatus: NOT_YET_RECRUITING date: 2024-05-06 date: 2025-05-06 date: 2025-10-31 date: 2024-04-29 date: 2024-04-29 name: Universit... |
The researchers are doing a detailed study with 40 women receiving paclitaxel treatment, tracking how the drug is processed in their bodies and how their body composition and physical activity might play a role in the side effects they experience. They are using a special method to monitor drug levels in the blood and ... |
The goal here is twofold: first, to better understand why these side effects happen to some people and not others, and second, to develop a model that can predict who might be at higher risk for these side effects based on their body composition, lifestyle, and how their body handles the drug. This could lead to more p... |
In simpler terms, this research is trying to find a way to make breast cancer treatment with paclitaxel safer and more comfortable by considering how a person's lifestyle and body type might affect their reaction to the drug. This could make a big difference in helping patients complete their treatment successfully and... |
<|newrecord|> nctId: NCT06387888 id: E-31034136-302.08.01-4221 briefTitle: The Effect of Mother's Voice on the Levels of Pain and Comfort in Newborns acronym: Newborn overallStatus: COMPLETED date: 2021-07-01 date: 2021-09-01 date: 2022-04-30 date: 2024-04-29 date: 2024-04-29 name: Istanbul Medipol University Hospital ... |
<|newrecord|> nctId: NCT06387875 id: Hangzhou Bay Cohort briefTitle: Cohort in Qianwan New District, Ningbo overallStatus: RECRUITING date: 2023-11-01 date: 2027-06-30 date: 2027-06-30 date: 2024-04-29 date: 2024-04-29 name: RenJi Hospital class: OTHER name: Ningbo Hangzhou Bay Hospital briefSummary: Our objective is t... |
<|newrecord|> nctId: NCT06387862 id: 2022SIMBIOV briefTitle: Pharmacokinetics of Inhaled Levosimendan acronym: Symbiov overallStatus: NOT_YET_RECRUITING date: 2024-04-20 date: 2024-11 date: 2025-01 date: 2024-04-29 date: 2024-04-29 name: Universitair Ziekenhuis Brussel class: OTHER briefSummary: Determination of biolog... |
<|newrecord|> nctId: NCT06387849 id: 03/2023 briefTitle: Aromatherapy Effect on Pain and Anxiety After C-section overallStatus: COMPLETED date: 2023-04-21 date: 2023-08-31 date: 2023-08-31 date: 2024-04-29 date: 2024-04-29 name: University Tunis El Manar class: OTHER briefSummary: A prospective randomized triple blinde... |
The aim of this study was to evaluate the effectiveness of lavender aromatherapy on postoperative pain and anxiety after cesarean section under spinal anesthesia in Tunisian women. conditions: Post-operative Pain conditions: Post-operative Anxiety studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED intervention... |
<|newrecord|> nctId: NCT06387836 id: B2024-063 briefTitle: LINC01844 as a Diagnostic Biomarker for POCD in Elderly Patients overallStatus: RECRUITING date: 2024-02-21 date: 2025-02-21 date: 2025-06-30 date: 2024-04-29 date: 2024-04-29 name: Shanghai Zhongshan Hospital class: OTHER briefSummary: Postoperative cognitive ... |
Does the relative level of LINC01844 in blood help diagnose POCD of older people after surgery? Participants undergoing elective lumbar decompression and fusion will finish neuropsychological evaluations one day before and 1st, 3rd and 5th day after surgery. At the same timepoint, the relative level of LINC01844 in blo... |
<|newrecord|> nctId: NCT06387823 id: K5321 briefTitle: Efficacy and Safety of Sivelestat Sodium and Dexamethasone in the Treatment of ARDS acronym: STAR overallStatus: NOT_YET_RECRUITING date: 2024-04-27 date: 2025-06-01 date: 2025-09-01 date: 2024-04-29 date: 2024-04-29 name: Peking Union Medical College Hospital clas... |
* Is Sivelestat sodium more effective in the treatment of patients with moderate to severe ARDS compared with placebo? |
* Is dexamethasone more effective in the treatment of patients with moderate to severe ARDS compared with placebo? Participants will receive Sivelestat sodium, dexamethasone or placebo. Researchers will compare the efficacy and safety of Sivelestat sodium, dexamethasone and placebo. conditions: Acute Respiratory Distre... |
<|newrecord|> nctId: NCT06387810 id: MA-PC-II-010 briefTitle: Irinotecan Liposome II in Combination With 5-FU/LV and Oxaliplatin in Perioperative Treatment of Borderline Resectable Pancreatic Cancer acronym: undetermined overallStatus: NOT_YET_RECRUITING date: 2024-04-17 date: 2026-04-30 date: 2026-06-30 date: 2024-04-... |
<|newrecord|> nctId: NCT06387797 id: UNLV-2023-321 briefTitle: Primary and Secondary Prevention of Type 2 Diabetes Mellitus in Clark County overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2025-05-30 date: 2025-05-31 date: 2024-04-29 date: 2024-04-29 name: University of Nevada, Las Vegas class: OTHER name: Univ... |
1. Cooking Matters for Adults (CMA) Curriculum Delivery over 6 weeks |
2. CMA + Enhanced cooking classes with added components comprising cooking practices specific to diabetes prevention, online information as well as short assignments and activities regarding sleep, stress, physical activity, and sedentary behaviors. The CMA+ arm will also have the opportunity to use a continuous glucos... |
<|newrecord|> nctId: NCT06387784 id: 2024/823 briefTitle: Acute Beetroot Juice Supplementation in Pre-eclampsia Pregnancies acronym: BEET_PE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2024-12 date: 2025-06 date: 2024-04-29 date: 2024-04-29 name: University of Sao Paulo class: OTHER name: Hospital das Clínica... |
<|newrecord|> nctId: NCT06387771 id: rs4680-tolcapona briefTitle: Evaluation of Tolcapone as a Cognitive Enhancer in Schizophrenia overallStatus: RECRUITING date: 2014-09-22 date: 2025-08 date: 2024-04-29 date: 2024-04-29 name: Clinica Universidad de Navarra, Universidad de Navarra class: OTHER briefSummary: Objective:... |
Methodology: 20 patients with chronic and stabilized schizophrenia (10 patients with genotype Val/Val and 10 patients with genotype Met/Met according to polymorphism rs4680) will receive treatment with tolcapone during 7 days. The cognitive function and clinical status will be evaluated with a neuropsychological batter... |
Hypothesis: Only patients with genotype Val/Val treated with tolcapone would show a cognitive improvement, a higher efficiency of the activation of the prefrontal cortex and an amelioration of some negative symptoms. conditions: Schizophrenia studyType: INTERVENTIONAL phases: PHASE2 allocation: NA interventionModel: SI... |
<|newrecord|> nctId: NCT06387758 id: UMMC-IRB-2022-473 briefTitle: Low Systemic/High Local Exercise Load in Peds SCD overallStatus: RECRUITING date: 2023-09-19 date: 2025-06-30 date: 2025-06-30 date: 2024-04-29 date: 2024-04-29 name: University of Mississippi Medical Center class: OTHER name: University of Alabama at B... |
<|newrecord|> nctId: NCT06387745 id: US-REFERRAL briefTitle: Referral of Patients to Hepatology With Hepatoscope acronym: US-REFERRAL overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2025-12 date: 2025-12 date: 2024-04-29 date: 2024-04-29 name: University Hospital, Antwerp class: OTHER name: E-Scopics briefSummary... |
<|newrecord|> nctId: NCT06387732 id: 161223 briefTitle: Mechanisms Underlying Antidepressant Effects of Physical Activity acronym: LIFE overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2027-08 date: 2028-01 date: 2024-04-29 date: 2024-04-29 name: University College, London class: OTHER name: King's College London ... |
To date the mechanisms driving the antidepressant effects of physical activity in humans are poorly understood. Building on links between depressive symptoms, reward processing and dopamine, plus evidence from animal studies that physical activity is anti-inflammatory and boosts both dopamine and reward processing, the... |
The key objective is to conduct a randomised controlled trial (RCT) in N=250 depressed participants comparing aerobic exercise to a stretching/relaxation control condition, examining a range of mechanistic factors. The proposed trial will examine the impact of physical activity at multiple, linked potential levels of e... |
<|newrecord|> nctId: NCT06387719 id: PREC-BED Study briefTitle: Precursors of Binge Eating Disorder in a Clinical Sample of Adolescents With Obesity acronym: PREC-BED overallStatus: RECRUITING date: 2023-07-21 date: 2025-03 date: 2026-05 date: 2024-04-29 date: 2024-04-29 name: Fundació Sant Joan de Déu class: OTHER nam... |
<|newrecord|> nctId: NCT06387706 id: GAP briefTitle: The Development of a Gamified Web-based Pain Management Program (GAP) for Community-dwelling Older Adults With Chronic Pain overallStatus: RECRUITING date: 2023-12-01 date: 2024-07-30 date: 2024-11-30 date: 2024-04-29 date: 2024-04-29 name: The Hong Kong Polytechnic ... |
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