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The presence of brain metastases is the most important prognostic factor. The neurological symptoms caused by the presence of these lesions, but also by the local treatments offered, affect patients' quality of life, although improvements in surgical and radiotherapy techniques have significantly reduced the need for p... |
International guidelines do not recommend systematic brain MRI in the absence of neurological symptoms, either in the adjuvant or metastatic stages of this disease. However, there may be a role for more systematic and earlier screening for cerebral recurrence, as single cerebral recurrences without extracranial involve... |
To date, no clinical or histological prognostic factor (proliferation index, HR expression, etc.) has been used to identify a population of patients at high risk of cerebral relapse, allowing monitoring and treatment to be personalised. |
New tools for these indications would significantly modify our clinical practice, allowing the identification of a subpopulation at high risk of cerebral recurrence, suitable for increased monitoring and therapeutic adjustment. conditions: HER2-positive Breast Cancer studyType: OBSERVATIONAL observationalModel: COHORT ... |
<|newrecord|> nctId: NCT06358612 id: DALNSHA2024ABR001 briefTitle: Evaluation of an Anxiety Reduction Tool During Thyroid and Prostate Biopsy Procedures overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-12-20 date: 2025-08-31 date: 2024-04-10 date: 2024-04-10 name: Nova Scotia Health Authority class: OTHER ... |
<|newrecord|> nctId: NCT06358599 id: TUO-UR-21-01 briefTitle: The Impact of Neoadjuvant Chemotherapy on Survival Outcomes in Patients With Variant Histologies Bladder Cancer Who Underwent Radical Cystectomy overallStatus: COMPLETED date: 2021-01-07 date: 2023-10-20 date: 2024-01-15 date: 2024-04-10 date: 2024-04-10 nam... |
<|newrecord|> nctId: NCT06358586 id: 044(H)MD21176 id: CRO-PK-21-356 type: OTHER domain: CRO code briefTitle: New Paediatric Formulation of Tachipirina® overallStatus: COMPLETED date: 2022-04-09 date: 2022-04-25 date: 2022-04-25 date: 2024-04-10 date: 2024-04-10 name: Aziende Chimiche Riunite Angelini Francesco S.p.A c... |
The aim of the present study is to investigate the palatability of the newly developed Tachipirina® 120 mg/5 mL oral suspension with strawberry flavour. The study will be conducted in paediatric volunteers that represent the target population for this product. conditions: Healthy studyType: INTERVENTIONAL phases: NA al... |
<|newrecord|> nctId: NCT06358573 id: SAKK 66/22 briefTitle: Intratumoral INT230-6 Followed by Neoadjuvant Immuno-chemotherapy in Patients With Early TNBC. INVINCIBLE-4-SAKK overallStatus: NOT_YET_RECRUITING date: 2024-06-30 date: 2026-03 date: 2029-12 date: 2024-04-10 date: 2024-04-10 name: Swiss Group for Clinical Can... |
<|newrecord|> nctId: NCT06358560 id: BrainHealthClinics briefTitle: Applied Clinical Neuroscience and Its Effect on Self-reported Stress and Other Physiological Markers overallStatus: RECRUITING date: 2024-03-04 date: 2024-12-15 date: 2024-12-15 date: 2024-04-10 date: 2024-04-10 name: Dylan Saulsbery class: OTHER brief... |
<|newrecord|> nctId: NCT06358547 id: H-23072469 briefTitle: Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Women Aged 37-41 Years overallStatus: NOT_YET_RECRUITING date: 2024-04-01 date: 2028-04-01 date: 2029-04-01 date: 2024-04-10 date: 2024-04-10 name: Rigshospitalet, Denmark class: OTHER briefSummary: A m... |
<|newrecord|> nctId: NCT06358534 id: RTEU-SBF-KB-01 briefTitle: The Effect of Acceptance and Commitment Therapy in Patients With Chronic Renal Failure overallStatus: ACTIVE_NOT_RECRUITING date: 2023-06-01 date: 2023-11-30 date: 2024-07-30 date: 2024-04-10 date: 2024-04-26 name: Recep Tayyip Erdogan University class: OT... |
<|newrecord|> nctId: NCT06358521 id: 6040471 briefTitle: Determining the Impact of a Physiotherapist-led Primary Care Model for Hip and Knee Pain - A Cluster Trial overallStatus: RECRUITING date: 2023-10-02 date: 2025-11-01 date: 2025-11-01 date: 2024-04-10 date: 2024-04-10 name: Queen's University class: OTHER name: C... |
<|newrecord|> nctId: NCT06358508 id: VP-0786 briefTitle: Sapphire 3 CTO Study overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-07 date: 2025-07 date: 2024-04-10 date: 2024-04-15 name: OrbusNeich class: INDUSTRY name: Avania briefSummary: A prospective, open label, multi-center, single arm, observational study... |
One hundred seventy (170) subjects will be enrolled with a target of one hundred fifty-three (153) evaluable subjects by the angiographic core laboratory at up to 15 clinical sites with the Sapphire 3 0.85, 1.0 and 1.25mm diameter PTCA dilatation catheter to pre-dilate CTO lesions in coronary arteries during their inde... |
<|newrecord|> nctId: NCT06358495 id: REB24-0253 briefTitle: Improving Sleep to Prevent Depression & Anxiety in Adolescents at High Risk overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-30 date: 2025-07-30 date: 2024-04-10 date: 2024-04-15 name: University of Calgary class: OTHER name: Hotchkiss Brain In... |
<|newrecord|> nctId: NCT06358482 id: ORAL1 briefTitle: Electric Toothbrush Efficacy in Preventing Dental Plaque Development acronym: E-TOOTH overallStatus: RECRUITING date: 2023-01-30 date: 2024-04-30 date: 2024-07-30 date: 2024-04-10 date: 2024-04-15 name: Riccardo Polosa class: OTHER briefSummary: The present study w... |
<|newrecord|> nctId: NCT06358469 id: VU2 briefTitle: STRatIfication of Vulvar SCC by HPV and p53 Status to Guide Excision acronym: STRIVE overallStatus: NOT_YET_RECRUITING date: 2024-06-30 date: 2030-06-30 date: 2031-11-30 date: 2024-04-10 date: 2024-04-10 name: Canadian Cancer Trials Group class: NETWORK name: Austral... |
<|newrecord|> nctId: NCT06358456 id: 20-928 briefTitle: Influence of Artificial Tears on Keratometry and Biometry Measurements With Different Devices overallStatus: COMPLETED date: 2020-11-20 date: 2022-04-22 date: 2022-04-22 date: 2024-04-10 date: 2024-04-10 name: University Clinic Frankfurt class: OTHER briefSummary:... |
* Do artificial tears alter the measurements of the corneal surface |
* Is there a difference between the devices used in this study |
This is relevant because high quality measurements improve the postoperative outcome after cataract surgery. conditions: Healthy studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionModel: PARALLEL interventionModelDescription: one arm for each diagnostic device (three in total) primaryPurpose: DIAGN... |
<|newrecord|> nctId: NCT06358443 id: PF-Jarlsberg/IIIB briefTitle: The Long-term Effect of Daily Jarlsberg Cheese Intake in Patient With Osteopenia acronym: PF-JB3 overallStatus: NOT_YET_RECRUITING date: 2024-04-02 date: 2024-10-18 date: 2025-02-23 date: 2024-04-10 date: 2024-04-10 name: Meddoc class: OTHER name: Tine ... |
Study population: Post-menopausal women and men above 55 years of age in risk of Osteoporosis Treatment: Daily OED Jarlsberg cheese + vitamin D and Calcium tablets. Design: An open and one-armed observational study. Main variables: Bone Mineral Density (BMD), Bone turnover markers (BTMs), Osteocalcin and K2 vitameres. |
Study Procedure: Prior to inclusion in this study, all the patients have undergone 32 days of daily OED intake of Jarlsberg cheese + vitamin D and caicium tablets. Thid is the baseline of this observational study. The duration of this study is 12 months with clinical examination and bloodsampling after 6 and 12 months. |
Sample size: At least 16 patients will be included conditions: Osteoporosis conditions: Osteopenia studyType: INTERVENTIONAL phases: NA allocation: NA interventionModel: SINGLE_GROUP interventionModelDescription: One armed observational study primaryPurpose: PREVENTION masking: NONE count: 20 type: ESTIMATED name: Jarl... |
<|newrecord|> nctId: NCT06358430 id: 2023-1017 id: NCI-2024-03107 type: OTHER domain: NCI-CTRP Clinical Registry briefTitle: Phase 1 Dose Escalation and Expansion Study of TROP2 CAR Engineered IL-15- Transduced Cord Blood-derived NK Cells in Combination With Cetuximab in Patient With Colorectal Cancer (CRC) With Minima... |
<|newrecord|> nctId: NCT06358417 id: 2024P000873 briefTitle: CHW Intervention to Improve Nutrition Security of Patients With Hypertension acronym: HeartWell overallStatus: NOT_YET_RECRUITING date: 2024-08-01 date: 2027-01-31 date: 2027-05-01 date: 2024-04-10 date: 2024-04-10 name: Massachusetts General Hospital class: ... |
<|newrecord|> nctId: NCT06358404 id: 2024P000615 briefTitle: Developing a Peer Support Intervention for Depression in SCD overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2026-04-30 date: 2026-04-30 date: 2024-04-10 date: 2024-04-10 name: Massachusetts General Hospital class: OTHER name: National Institutes of ... |
<|newrecord|> nctId: NCT06358391 id: TS-RF system briefTitle: To Compare and Evaluate the Efficacy and Safety Between TS-RF System and BRK Transseptal Needles Used for Transseptal Puncture for Left Atrial Access. overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-12-31 date: 2025-03-31 date: 2024-04-10 date:... |
<|newrecord|> nctId: NCT06358378 id: 995 briefTitle: Accuracy of Cuffless Ambulatory Blood Pressure Monitors Compared to Cuff-based Monitors in an Ambulatory Elderly Population: A Pilot Study overallStatus: NOT_YET_RECRUITING date: 2024-04-15 date: 2024-08-30 date: 2024-09-30 date: 2024-04-10 date: 2024-04-10 name: Sli... |
Several novel cuffless wearables have been developed to overcome the limitations of cuff-based monitors. These devices offer significant advantages over cuff-based devices, including improved patient tolerance and user acceptability. Numerous cuffless monitors are now commercially available. However, validation of such... |
There are limited clinical trials comparing 24-hour cuff-based devices directly to cuffless devices, and even fewer specifically in an elderly population where they may be particularly advantageous due to design features that improve tolerability. This study thus aims to address this important gap in the literature to ... |
<|newrecord|> nctId: NCT06358365 id: AQP-DCL-026 briefTitle: Enhancing Fluid Transfer Through the Skin, by Increased Sweat Rate, on Hemodialysis Patients overallStatus: COMPLETED date: 2023-03-29 date: 2023-11-02 date: 2023-11-07 date: 2024-04-10 date: 2024-04-10 name: AquaPass Medical Ltd. class: INDUSTRY briefSummary... |
<|newrecord|> nctId: NCT06358352 id: M18080921 briefTitle: Clinical and Radiographic Assessment of PRF Versus Lutein Placement overallStatus: COMPLETED date: 2021-10-01 date: 2022-02-01 date: 2023-05-01 date: 2024-04-10 date: 2024-04-10 name: Mansoura University class: OTHER briefSummary: Thirty patients seeking for pr... |
Inclusion criteria: 1. Badly destructed maxillary single rooted teeth due to trauma or caries. 2. Age between 20 and 45 years. 3. Good oral hygiene. 4. Patients willing to complete the study follow up intervals. 5. Patients will be informed about the aim of the study and a written consent will be obtained. The patients... |
Exclusion criteria: 1. periapical infection in the teeth to be replaced. 2. Alcohol or drug abuse. 3. Patients with systemic diseases that absolutely contraindicate implant placement 4. Pregnancy. 5. Patients with parafunctional habits (bruxism and clenching) 6. Uncooperative patients 7. Heavy smokers. |
7 |
Patients grouping: Patients will be randomly divided into three groups: |
Group A: Immediate implant placement with leaving the gap distance empty |
Group B: Immediate implant placement then placement of PRF around the implant in the gap distance |
Group C: Immediate implant placement then placement of lutein around the implant in the gap distance |
Clinical evaluation: |
Patients will be evaluated clinically for: |
1-Postoperative Pain: By using a 10-point Visual Analogue Scale (VAS) for assessment of pain by the patient on the 1st, 3rd, and 7th days after surgery.(10) (0-1=None, 2-4=Mild, 5-7=Moderate, 8-10=Severe) 2. Implant stability Will be assessed at the time of implant insertion and at a period of 3, 6 and 12 months interv... |
3. Sulcus Bleeding Index (SBI) An early sign of gingivitis is bleeding on probing and, in 1971, Muhlemann and Son described the Sulcus Bleeding Index (SBI). It will be assessed at 3, 6 and 12 months intervals. |
4. Peri-implant probing depth: Depth of the peri-implant sulcus will be made at 3, 6 and 12 months intervals with light force to avoid undue tissue damage and over-extension into the healthy tissue. |
Radiographic evaluation: |
conebeam CT will be done to evaluate the vertical and horizontal changes to the alveolar bone following immediate implant placement. It will be done immediately after implant placement , after 3 months and after 12 months conditions: Osteogenesis studyType: INTERVENTIONAL phases: NA allocation: RANDOMIZED interventionM... |
<|newrecord|> nctId: NCT06358339 id: 72374095 briefTitle: TEEM-GIFTS: A Gamified mHealth to Reduce Post-Discharge Suicide Risk overallStatus: NOT_YET_RECRUITING date: 2024-09-01 date: 2027-08-31 date: 2027-12-31 date: 2024-04-10 date: 2024-04-10 name: Shenzhen Kangning Hospital class: OTHER briefSummary: Patients with ... |
<|newrecord|> nctId: NCT06358326 id: Karabuk-1 briefTitle: Dry Needling and Rehabilitatin Carpal Tunnel Syndrome overallStatus: RECRUITING date: 2024-04-05 date: 2024-08-30 date: 2024-09-30 date: 2024-04-10 date: 2024-04-10 name: Karabuk University class: OTHER briefSummary: Dry needling is used for myofascial release.... |
<|newrecord|> nctId: NCT06358313 id: 0023098816 briefTitle: Concomitant Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Minor Stroke or TIA overallStatus: RECRUITING date: 2024-04-10 date: 2025-04-10 date: 2025-05-10 date: 2024-04-10 date: 2024-04-10 name: Kafrelsheikh University class: OTHER brie... |
<|newrecord|> nctId: NCT06358300 id: Usakpcos2 briefTitle: Visceral Adiposity Index Differences Between Subtypes of Polycystic Ovary Syndrome overallStatus: COMPLETED date: 2022-01-01 date: 2022-09-01 date: 2023-07-20 date: 2024-04-10 date: 2024-04-10 name: Uşak University class: OTHER briefSummary: We aimed to investi... |
<|newrecord|> nctId: NCT06358287 id: STUDY19030375 briefTitle: Neural Correlates of Auriculotherapy overallStatus: COMPLETED date: 2021-07-15 date: 2022-11-07 date: 2022-11-07 date: 2024-04-10 date: 2024-04-10 name: Keith M. Vogt, MD, PhD class: OTHER briefSummary: Chronic pain continues to be a major health issue, cre... |
<|newrecord|> nctId: NCT06358274 id: MED-2024-32848 briefTitle: Nutritional and Metabolic Dynamics of Thru-Hiking: A Longitudinal Study on the Colorado Trail overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2024-07-01 date: 2024-07-01 date: 2024-04-10 date: 2024-04-10 name: University of Minnesota class: OTHER ... |
The specific aims include examining the metabolic responses and cardiovascular implications associated with thru-hiking, exploring correlations between dietary intake and blood lipid profiles, and elucidating the interplay between lifestyle factors and metabolic health in demanding environments. This study is not limit... |
<|newrecord|> nctId: NCT06358261 id: IRB00433279 id: R03DK135898 type: NIH link: https://reporter.nih.gov/quickSearch/R03DK135898 briefTitle: Study of a Diabetes Prevention Patient Activation Clinical Decision Support Tool overallStatus: NOT_YET_RECRUITING date: 2024-06 date: 2025-09 date: 2025-09 date: 2024-04-10 date... |
<|newrecord|> nctId: NCT06358248 id: SPHERE briefTitle: Standardized Physician-modified Fenestrated Endograft Registry acronym: SPHERE overallStatus: RECRUITING date: 2023-10-01 date: 2028-10-01 date: 2033-10-01 date: 2024-04-10 date: 2024-04-16 name: University Hospital Padova class: OTHER briefSummary: Multicenter re... |
<|newrecord|> nctId: NCT06358235 id: SDU-IH-HA-01 briefTitle: The Effect of Music Therapy on Dyspnea Severity and Vital Signs overallStatus: RECRUITING date: 2024-01-07 date: 2024-05-30 date: 2024-06-30 date: 2024-04-10 date: 2024-04-10 name: Suleyman Demirel University class: OTHER briefSummary: This study aims to inv... |
Patients in the experimental group will receive music therapy in the Hüseyni maqam, while those in the control group will not receive any music therapy. Life indicators and Modified Borg Scale (MBS) values of patients in the experimental group will be recorded before, immediately after, and 30 minutes post-application.... |
<|newrecord|> nctId: NCT06358222 id: LUNon-invasive briefTitle: Predicting Non-small Cell Lung Cancer (NSCLC) Lymph Node Metastasis: Integrating Circulating Tumor DNA (ctDNA) Mutation/ Methylation Profiling With Positron Emission Tomography-computed Tomography (PET-CT) Scan overallStatus: RECRUITING date: 2023-12-15 da... |
<|newrecord|> nctId: NCT06358209 id: LY2024-045-B briefTitle: Safety and Efficacy of Ventricular Irrigation for Ventriculitis overallStatus: NOT_YET_RECRUITING date: 2024-06-01 date: 2026-05-30 date: 2026-05-30 date: 2024-04-10 date: 2024-04-10 name: RenJi Hospital class: OTHER name: Southern Medical University, China ... |
Currently, treatments for ventriculitis recommended by guidelines primarily focus on the selection and administration of antibiotics, while the effects of surgical interventions have not been fully elucidated. In recent years, several studies have explored the use of ventricular irrigation in ventriculitis, indicating ... |
This multicenter randomized controlled trial aims to explore the safety and effectiveness of ventricular irrigation compared to conventional treatment for severe ventriculitis, analyze the effectiveness of ventricular irrigation across different pathogen subgroups, and investigate independent risk factors for different... |
<|newrecord|> nctId: NCT06358196 id: CESAH briefTitle: Complex Exploratory Study of Alcohol-Associated Hepatitis acronym: CESAH overallStatus: NOT_YET_RECRUITING date: 2024-05-01 date: 2025-04-30 date: 2026-04-30 date: 2024-04-10 date: 2024-04-10 name: Pavol Jozef Safarik University class: OTHER name: L Pasteur Univers... |
<|newrecord|> nctId: NCT06358183 id: ESC001 briefTitle: Surgical Capacity in Zimbabwean Public Hospitals overallStatus: COMPLETED date: 2019-04-24 date: 2024-02-25 date: 2024-03-15 date: 2024-04-10 date: 2024-04-10 name: Parirenyatwa Hospital class: OTHER briefSummary: This study aimed to understand how ready Zimbabwe'... |
<|newrecord|> nctId: NCT06358170 id: NYCU112169AF briefTitle: Effects of Circuit Training Combine With Square-Stepping Exercise, Strength Training and Balance Training on Senior Fitness and Fall Risk in Elderly in the Community acronym: SSE overallStatus: RECRUITING date: 2024-03-01 date: 2024-07-01 date: 2024-07-01 da... |
<|newrecord|> nctId: NCT06358157 id: CLN02001 briefTitle: The Ladera Large Bore Closure Feasibility Study overallStatus: NOT_YET_RECRUITING date: 2024-07 date: 2024-12 date: 2025-02 date: 2024-04-10 date: 2024-04-10 name: Ladera Medical class: INDUSTRY name: Avania briefSummary: This study evaluates the safety and perf... |
<|newrecord|> nctId: NCT06358144 id: IRB00111438 id: R01DA053209 type: NIH link: https://reporter.nih.gov/quickSearch/R01DA053209 briefTitle: Cannabis Edibles Packaging Imagery Experiment overallStatus: NOT_YET_RECRUITING date: 2024-05 date: 2024-07 date: 2024-07 date: 2024-04-10 date: 2024-04-10 name: Wake Forest Univ... |
<|newrecord|> nctId: NCT06358131 id: R.21.10.1493 briefTitle: Propofol Versus Midazolam in Sedation for Upper and Lower Gastrointestinal Endoscopy. overallStatus: RECRUITING date: 2022-01-01 date: 2024-08-01 date: 2024-08-01 date: 2024-04-10 date: 2024-04-10 name: Mansoura University class: OTHER briefSummary: There ha... |
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