panel_design/split/9_top50.csv

Unnamed: 0,Gene symbol,Ranking,Annotation & reasoning,Additional note,Paper links,Gene Symbol
1,SNAP25,1.0,Regional and laminal marker : Gray matter ,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed,SNAP25
2,MBP,2.0,Regional and laminal marker : White matter ,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed,MBP
3,PCP4,3.0,Regional and laminal marker :  L5 ,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed,PCP4
4,RELN,4.0,Regional and laminal marker :  L1 / Gabaergic neuron subclass: LAMP5/RELN/LHX7,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed,RELN
5,NR4A2,5.0,Regional and laminal marker :  L6 ,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed,NR4A2
6,HTRA1,6.0,Regional and laminal marker :  L1 sublayer,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed,HTRA1
7,SPARC,7.0,Regional and laminal marker :  L1 sublayer,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed,SPARC
8,CLDN5,8.0,Brain vasculature/endothelial cell marker,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed,CLDN5
9,AQP4,9.0,Regional and laminal marker :  L1 /Astrocyte marker,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed,AQP4
10,NeuN,10.0,Neuronal marker,"Key neuron parent annotation: Linnarson lab - Siletti et al., 2023 - Transcriptomic diversity of cell types across the adult human brain",https://www.science.org/doi/10.1126/science.add7046#supplementary-materials,NeuN
11,INA,11.0,Neuronal marker,"Key neuron parent annotation: Linnarson lab - Siletti et al., 2023 - Transcriptomic diversity of cell types across the adult human brain",https://www.science.org/doi/10.1126/science.add7046#supplementary-materials,INA
12,SLC17A6,12.0,Glutamergic neuron marker,"Key neuron parent annotation: Linnarson lab - Siletti et al., 2023 - Transcriptomic diversity of cell types across the adult human brain",https://www.science.org/doi/10.1126/science.add7046#supplementary-materials,SLC17A6
13,SLC17A7,13.0,Glutamergic neuron marker,"Key neuron parent annotation: Linnarson lab - Siletti et al., 2023 - Transcriptomic diversity of cell types across the adult human brain",https://www.science.org/doi/10.1126/science.add7046#supplementary-materials,SLC17A7
14,SLC32A1,14.0,Gabaergic neuron marker ,"Key neuron parent annotation: Linnarson lab - Siletti et al., 2023 - Transcriptomic diversity of cell types across the adult human brain",https://www.science.org/doi/10.1126/science.add7046#supplementary-materials,SLC32A1
15,PTRPC,15.0,Immune cell marker,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,PTRPC
16,ACTA2,16.0,Smooth muscle cell,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,ACTA2
17,CEMIP,17.0,VCMC,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,CEMIP
18,PCDH8,18.0,Glutamergic neuron subclass: L3-3 IT ,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,PCDH8
19,OPRK1,19.0,Glutamergic neuron subclass: L6-IT 1/2 Glut,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,OPRK1
20,RORB,20.0,Glutamergic neuron subclass: L3-5IT 1/2/3 Glut,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,RORB
21,FEZF2,21.0,Glutamergic neuron subclass: L5ET,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,FEZF2
22,HTR2C,22.0,Glutamergic neuron subclass: L5-6 NP,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,HTR2C
23,SYT6,23.0,Glutamergic neuron subclass: L6 CT,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,SYT6
24,CTGF,24.0,Glutamergic neuron subclass: L6 B,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,CTGF
25,LAMP5,25.0,Gabaergic neuron subclass: LAMP5/RELN/LHX6,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,LAMP5
26,LHX6,26.0,Gabaergic neuron subclass: LAMP5/RELN/LHX8,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,LHX6
27,VIP,27.0,Gabaergic neuron subclass VIP,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,VIP
28,KCNG1,28.0,Gabaergic neuron subclass VIP KCNG1,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,KCNG1
29,SST,29.0,Gabaergic neuron subclass SST,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,SST
30,HGF,30.0,Gabaergic neuron subclass SST HGF,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,HGF
31,PVALB,31.0,Gabaergic neuron subclass SST PVALB,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,PVALB
32,CHC,32.0,Gabaergic neuron subclass SST PVALB CHC,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,CHC
33,FABP7,33.0,"Non neuronal subclass, Astrocytes and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,FABP7
34,AQP1,34.0,"Non neuronal subclass, Astrocytes and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,AQP1
35,SLC1A2,35.0,"Non neuronal subclass, Astrocytes and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,SLC1A2
36,GFAP,36.0,"Non neuronal subclass, Astrocytes and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,GFAP
37,OSMR,37.0,"Non neuronal subclass, Astrocytes and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,OSMR
38,PDGFRA,38.0,"Non neuronal subclass, OPC and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,PDGFRA
39,PCDH15,39.0,"Non neuronal subclass, OPC and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,PCDH15
40,MOG,40.0,"Non neuronal subclass, Oligodendrocytes and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,MOG
41,CDH7,41.0,"Non neuronal subclass, Oligodendrocytes and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,CDH7
42,OPALIN,42.0,"Non neuronal subclass, Oligodendrocytes and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,OPALIN
43,GSN,43.0,"Non neuronal subclass, Oligodendrocytes and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,GSN
45,P2RY12,44.0,"Non neuronal subclass, microglia and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,P2RY12
46,IGKC,45.0,"Immune cell, B cell ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,IGKC
47,CD247,46.0,"Immune cell, T cell ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,CD247
48,COLEC12,47.0,"Immune cell, Macrophage","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials,COLEC12
50,FOS,48.0,Neuronal activity gene - cFos,"Aparicio et al., 2022 - Current Opinion on the Use of c-Fos in Neuroscience",https://www.mdpi.com/2673-4087/3/4/50,FOS
51,CALM1,49.0,Neuronal activity gene - Calmodulin 1,"Jensen et al., 2024 - Neurological consequences of human calmodulin mutations
",https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10749624/,CALM1
52,APBB7IP,50.0,"Non neuronal subclass, microglia and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",,APBB7IP