panel_design/9.csv

Gene symbol,Ranking,Annotation & reasoning,Additional note,Paper links
,,"First 50 - regional/structural, cell type and subclass/subtype annotation, neuronal activation","In Schizophrenia, downregulation of neuronal activity in the DLPFC has been reported (Smucny et al., 2022 - https://www.nature.com/articles/s41386-021-01089-0). What neuronal cell types activity is affected and what non-neuronal and other cell types are proximal to the affected neuronal cell types?",
SNAP25,1.0,Regional and laminal marker : Gray matter ,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
MBP,2.0,Regional and laminal marker : White matter ,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
PCP4,3.0,Regional and laminal marker :  L5 ,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
RELN,4.0,Regional and laminal marker :  L1 / Gabaergic neuron subclass: LAMP5/RELN/LHX7,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
NR4A2,5.0,Regional and laminal marker :  L6 ,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
HTRA1,6.0,Regional and laminal marker :  L1 sublayer,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
SPARC,7.0,Regional and laminal marker :  L1 sublayer,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
CLDN5,8.0,Brain vasculature/endothelial cell marker,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
AQP4,9.0,Regional and laminal marker :  L1 /Astrocyte marker,"Region annotation: Maynard lab - Huuki-Myers et al., 2024 - A data-driven single-cell and spatial transcriptomic map of the human prefrontal cortex",https://www.science.org/doi/10.1126/science.adh1938?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
NeuN,10.0,Neuronal marker,"Key neuron parent annotation: Linnarson lab - Siletti et al., 2023 - Transcriptomic diversity of cell types across the adult human brain",https://www.science.org/doi/10.1126/science.add7046#supplementary-materials
INA,11.0,Neuronal marker,"Key neuron parent annotation: Linnarson lab - Siletti et al., 2023 - Transcriptomic diversity of cell types across the adult human brain",https://www.science.org/doi/10.1126/science.add7046#supplementary-materials
SLC17A6,12.0,Glutamergic neuron marker,"Key neuron parent annotation: Linnarson lab - Siletti et al., 2023 - Transcriptomic diversity of cell types across the adult human brain",https://www.science.org/doi/10.1126/science.add7046#supplementary-materials
SLC17A7,13.0,Glutamergic neuron marker,"Key neuron parent annotation: Linnarson lab - Siletti et al., 2023 - Transcriptomic diversity of cell types across the adult human brain",https://www.science.org/doi/10.1126/science.add7046#supplementary-materials
SLC32A1,14.0,Gabaergic neuron marker ,"Key neuron parent annotation: Linnarson lab - Siletti et al., 2023 - Transcriptomic diversity of cell types across the adult human brain",https://www.science.org/doi/10.1126/science.add7046#supplementary-materials
PTRPC,15.0,Immune cell marker,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
ACTA2,16.0,Smooth muscle cell,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
CEMIP,17.0,VCMC,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
PCDH8,18.0,Glutamergic neuron subclass: L3-3 IT ,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
OPRK1,19.0,Glutamergic neuron subclass: L6-IT 1/2 Glut,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
RORB,20.0,Glutamergic neuron subclass: L3-5IT 1/2/3 Glut,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
FEZF2,21.0,Glutamergic neuron subclass: L5ET,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
HTR2C,22.0,Glutamergic neuron subclass: L5-6 NP,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
SYT6,23.0,Glutamergic neuron subclass: L6 CT,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
CTGF,24.0,Glutamergic neuron subclass: L6 B,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
LAMP5,25.0,Gabaergic neuron subclass: LAMP5/RELN/LHX6,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
LHX6,26.0,Gabaergic neuron subclass: LAMP5/RELN/LHX8,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
VIP,27.0,Gabaergic neuron subclass VIP,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
KCNG1,28.0,Gabaergic neuron subclass VIP KCNG1,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
SST,29.0,Gabaergic neuron subclass SST,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
HGF,30.0,Gabaergic neuron subclass SST HGF,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
PVALB,31.0,Gabaergic neuron subclass SST PVALB,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
CHC,32.0,Gabaergic neuron subclass SST PVALB CHC,"Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
FABP7,33.0,"Non neuronal subclass, Astrocytes and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
AQP1,34.0,"Non neuronal subclass, Astrocytes and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
SLC1A2,35.0,"Non neuronal subclass, Astrocytes and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
GFAP,36.0,"Non neuronal subclass, Astrocytes and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
OSMR,37.0,"Non neuronal subclass, Astrocytes and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
PDGFRA,38.0,"Non neuronal subclass, OPC and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
PCDH15,39.0,"Non neuronal subclass, OPC and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
MOG,40.0,"Non neuronal subclass, Oligodendrocytes and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
CDH7,41.0,"Non neuronal subclass, Oligodendrocytes and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
OPALIN,42.0,"Non neuronal subclass, Oligodendrocytes and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
GSN,43.0,"Non neuronal subclass, Oligodendrocytes and subtypes","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
CCL3,,"Non neuronal subclass, microglia and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",
P2RY12,44.0,"Non neuronal subclass, microglia and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
IGKC,45.0,"Immune cell, B cell ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
CD247,46.0,"Immune cell, T cell ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
COLEC12,47.0,"Immune cell, Macrophage","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",https://www.science.org/doi/10.1126/science.abo7257#supplementary-materials
GLDN,,"Non neuronal subclass, microglia and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",
FOS,48.0,Neuronal activity gene - cFos,"Aparicio et al., 2022 - Current Opinion on the Use of c-Fos in Neuroscience",https://www.mdpi.com/2673-4087/3/4/50
CALM1,49.0,Neuronal activity gene - Calmodulin 1,"Jensen et al., 2024 - Neurological consequences of human calmodulin mutations
",https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10749624/
APBB7IP,50.0,"Non neuronal subclass, microglia and subtypes ","Neuronal subclass, non-neuronal subtypes annotation: Sheston lab - Ma et al., 2022 - Molecular and cellular evolution of the primate dorsolateral prefrontal cortex",
,,Next 50-100 - Synaptic markers and Schizophrenia risk genes in GRNs and Cell-Cell communication ,synaptic markers can aid in identifying cell-cell communications and disease relevant L-R pairs can aid in identifying downstream signalling  mechanisms ,
NRXN3,51.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
SYN1,52.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
SYN2,53.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
SYN3,54.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
SYP,55.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
SYT1,56.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
STX1A,57.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
VAMP2,58.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
VGAT,59.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
VGLUT1,60.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
VGLUT2,61.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
VGLUT3,62.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
GAP43,63.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
VMAT2,64.0,Pre synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
NRG1,65.0,Post synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
DLG4,66.0,Post synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
DLG3,67.0,Post synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
SHANK1,68.0,Post synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
SHANK3,69.0,Post synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
HOMER1,70.0,Post synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
HOMER2,71.0,Post synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
HOMER3,72.0,Post synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
GPHN,73.0,Post synaptic marker,https://www.alomone.com/synaptic-markers-for-pre-and-postsynaptic-regions?srsltid=AfmBOorvpugcJXthma_V9UY2fua_gCkNcxyRF6fHMPELLMW3HA5V5iv0#Presynaptic-Markers,
ICAM1,74.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5199
AKT1,75.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5200
MECP2,76.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5201
PTK2B,77.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5202
EPHA2,78.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5203
RARG,79.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5204
PML,80.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5205
EPB41,81.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5206
DMD,82.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5207
FOXO1,83.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5208
TEK,84.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5209
CDH5,85.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5210
COL3A1,86.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5211
HIST1HE,87.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5212
PRKDC,88.0,Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5213
HMGB1,89.0,Interacting ligands on non neuronal cells of Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5214
HMGB2,90.0,Interacting ligands on non neuronal cells of Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5215
PDGFB,91.0,Interacting ligands on non neuronal cells of Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5216
CRLF1,92.0,Interacting ligands on non neuronal cells of Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5217
NAMPT,93.0,Interacting ligands on non neuronal cells of Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5218
ANGPT1,94.0,Interacting ligands on non neuronal cells of Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5219
CXCL12,95.0,Interacting ligands on non neuronal cells of Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5220
ANGPT2,96.0,Interacting ligands on non neuronal cells of Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5221
PIK3CB,97.0,Interacting ligands on non neuronal cells of Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5222
SEMA5A,98.0,Interacting ligands on non neuronal cells of Schizophrenia risk gene receptors,"Ligand-receptor pairs Schizophrenia risk - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5223
,,"Key transcription factors (TFs) from cell type specific and broad gene regulatory networks (GRNs), Schizophrenia risk genes in GRNs",,
ZNF263,99.0,Transcription factor linked to GRN from prefrontal cortex (PFC) - Broad cell types ,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5199
MAZ,100.0,Transcription factor linked to GRN from prefrontal cortex (PFC) - Broad cell types ,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5200
ZNF148,101.0,Transcription factor linked to GRN from prefrontal cortex (PFC) - Broad cell types ,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5201
MEF2C,102.0,Transcription factor linked to GRN from prefrontal cortex (PFC) - Broad cell types ,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5202
SP2,103.0,Transcription factor linked to GRN from prefrontal cortex (PFC) - Broad cell types ,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5203
ZEB1,104.0,Transcription factor linked to GRN from prefrontal cortext (PFC) - more cell type specific,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5204
PU2F2,105.0,Transcription factor linked to GRN from prefrontal cortext (PFC) - more cell type specific,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5205
PPARA,106.0,Transcription factor linked to GRN from prefrontal cortext (PFC) - more cell type specific,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5206
PBX3,107.0,Transcription factor linked to GRN from prefrontal cortext (PFC) - more cell type specific,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5207
ELK4,108.0,Transcription factor linked to GRN from prefrontal cortext (PFC) - more cell type specific,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5208
ETV6,109.0,Transcription factor linked to GRN from prefrontal cortext (PFC) - more cell type specific,"GRNs and TFs - Emani et al., 2024, Single-cell genomics and regulatory networks for 388 human brains",https://www.science.org/doi/10.1126/science.adi5209
CLCN3,110.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
CNTN4,111.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
GATAD2A,112.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
GPM6A,113.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
MMP16,114.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
PSMA4,115.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
TCF4,116.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
NCAN,117.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
MAPK3,118.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
NMRAL1,119.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
CHRNB4,120.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
CHRNA3,121.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
CHRNA5,122.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
IREB2,123.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
PPP1R13B,124.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
BCL11B,125.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
PRKD1,126.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
OGFOD2,127.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
ATP2A2,128.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
SNX19,129.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
NRGN,130.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
DRD2,131.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
SERPING1,132.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
ZDHHC5,133.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
CACNB2,134.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
KCNV1,135.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
NNM16,136.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
SNAP91,137.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
GRIA1,138.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
PCDHA5,139.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
PCDHA8,140.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
HCN1,141.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
CLCN3,142.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
TMEM22,143.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
NEK4,144.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
PBRM1,145.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
ALMS1,146.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
VRK2,147.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
DUS2L,148.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
FURIN,149.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."
GRIN2A,150.0,Predicted causal Schizophrenia genes,"Predicted causal schizophrenia genes - Ma et al., 2018 - The integrated landscape of causal genes and pathways in schizophrenia","https://www.nature.com/articles/s41398-018-0114-x#:~:text=TCF4%20is%20one%20of%20the,a%20causal%20gene%20for%20schizophrenia."