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The authors describe a case of interstitial granulomatous dermatitis associated with darifenacin.
|
[
{
"ade": "interstitial granulomatous dermatitis",
"drug": "darifenacin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The authors describe a case of interstitial granulomatous dermatitis associated with darifenacin.",
"role": "user"
},
{
"content": "[{'ade': 'interstitial granulomatous dermatitis', 'drug': 'darifenacin'}]",
"role": "assistant"
}
] |
When DSCG was withdrawn, urticaria vanished and the child remained symptom-free.
|
[
{
"ade": "urticaria",
"drug": "DSCG"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: When DSCG was withdrawn, urticaria vanished and the child remained symptom-free.",
"role": "user"
},
{
"content": "[{'ade': 'urticaria', 'drug': 'DSCG'}]",
"role": "assistant"
}
] |
Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.
|
[
{
"ade": "Retinopathy",
"drug": "ribavirin"
},
{
"ade": "Retinopathy",
"drug": "pegylated interferon"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Retinopathy in hepatitis C patients due to combination therapy with pegylated interferon and ribavirin.",
"role": "user"
},
{
"content": "[{'ade': 'Retinopathy', 'drug': 'ribavirin'}, {'ade': 'Retinopathy', 'drug': 'pegylated interferon'}]",
"role": "assistant"
}
] |
Torsade de pointes during loading with amiodarone.
|
[
{
"ade": "Torsade de pointes",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Torsade de pointes during loading with amiodarone.",
"role": "user"
},
{
"content": "[{'ade': 'Torsade de pointes', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
An amiodarone optic neuropathy has been described.
|
[
{
"ade": "optic neuropathy",
"drug": "amiodarone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: An amiodarone optic neuropathy has been described.",
"role": "user"
},
{
"content": "[{'ade': 'optic neuropathy', 'drug': 'amiodarone'}]",
"role": "assistant"
}
] |
Prior to surgery, levodopa induced dyskinesia had improved (< or = 50%) under treatment with amantadine (400 mg/day, po) in all three patients.
|
[
{
"ade": "dyskinesia",
"drug": "levodopa"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Prior to surgery, levodopa induced dyskinesia had improved (< or = 50%) under treatment with amantadine (400 mg/day, po) in all three patients.",
"role": "user"
},
{
"content": "[{'ade': 'dyskinesia', 'drug': 'levodopa'}]",
"role": "assistant"
}
] |
METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.
|
[
{
"ade": "vomiting",
"drug": "Viokase"
},
{
"ade": "vomiting",
"drug": "Pancrease MT 16"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: METHODS: Double-blind, placebo-controlled titrated oral challenges with pancreatic enzymes resulted in definite vomiting within 1 to 1.5 hours after challenges with Viokase and Pancrease MT 16, but not with placebo.",
"role": "user"
},
{
"content": "[{'ade': 'vomiting', 'drug': 'Viokase'}, {'ade': 'vomiting', 'drug': 'Pancrease MT 16'}]",
"role": "assistant"
}
] |
It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.
|
[
{
"ade": "hypersensitivity syndrome",
"drug": "dapsone"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: It may cause a severe adverse drug reaction with multiorgan involvement known as dapsone hypersensitivity syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'hypersensitivity syndrome', 'drug': 'dapsone'}]",
"role": "assistant"
}
] |
The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.
|
[
{
"ade": "electrophysiologic effect",
"drug": "procainamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The failure of therapy with disopyramide and mexiletine to reproduce this observation suggests either a previously unreported electrophysiologic effect of, or idiosyncratic response to, procainamide.",
"role": "user"
},
{
"content": "[{'ade': 'electrophysiologic effect', 'drug': 'procainamide'}]",
"role": "assistant"
}
] |
Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide.
|
[
{
"ade": "Acute intravascular hemolysis",
"drug": "glyburide"
},
{
"ade": "Acute intravascular hemolysis",
"drug": "chlorpropamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide.",
"role": "user"
},
{
"content": "[{'ade': 'Acute intravascular hemolysis', 'drug': 'glyburide'}, {'ade': 'Acute intravascular hemolysis', 'drug': 'chlorpropamide'}]",
"role": "assistant"
}
] |
Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.
|
[
{
"ade": "DRESS",
"drug": "Linezolid"
},
{
"ade": "drug rash with eosinophilia and systemic symptoms",
"drug": "Linezolid"
},
{
"ade": "acute interstitial nephritis",
"drug": "Linezolid"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Linezolid-associated acute interstitial nephritis and drug rash with eosinophilia and systemic symptoms (DRESS) syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'DRESS', 'drug': 'Linezolid'}, {'ade': 'drug rash with eosinophilia and systemic symptoms', 'drug': 'Linezolid'}, {'ade': 'acute interstitial nephritis', 'drug': 'Linezolid'}]",
"role": "assistant"
}
] |
Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.
|
[
{
"ade": "nephrotoxicity",
"drug": "cisplatinum"
},
{
"ade": "cardiotoxicity",
"drug": "adriamycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Complications of chemotherapy for a synovial sarcoma in an eight-year old boy included cisplatinum nephrotoxicity and adriamycin cardiotoxicity.",
"role": "user"
},
{
"content": "[{'ade': 'nephrotoxicity', 'drug': 'cisplatinum'}, {'ade': 'cardiotoxicity', 'drug': 'adriamycin'}]",
"role": "assistant"
}
] |
Triazolam-induced nocturnal bingeing with amnesia.
|
[
{
"ade": "amnesia",
"drug": "Triazolam"
},
{
"ade": "nocturnal bingeing",
"drug": "Triazolam"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Triazolam-induced nocturnal bingeing with amnesia.",
"role": "user"
},
{
"content": "[{'ade': 'amnesia', 'drug': 'Triazolam'}, {'ade': 'nocturnal bingeing', 'drug': 'Triazolam'}]",
"role": "assistant"
}
] |
When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.
|
[
{
"ade": "vague symptoms",
"drug": "desmopressin"
},
{
"ade": "hyponatremia",
"drug": "desmopressin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: When vague symptoms develop during desmopressin therapy, hyponatremia must be considered as part of the differential diagnosis.",
"role": "user"
},
{
"content": "[{'ade': 'vague symptoms', 'drug': 'desmopressin'}, {'ade': 'hyponatremia', 'drug': 'desmopressin'}]",
"role": "assistant"
}
] |
A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.
|
[
{
"ade": "massive proteinuria",
"drug": "methicillin"
},
{
"ade": "acute nephritic syndrome",
"drug": "methicillin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: A drug addict with staphylococcal endocarditis treated with methicillin, who developed massive proteinuria and acute nephritic syndrome is described.",
"role": "user"
},
{
"content": "[{'ade': 'massive proteinuria', 'drug': 'methicillin'}, {'ade': 'acute nephritic syndrome', 'drug': 'methicillin'}]",
"role": "assistant"
}
] |
Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.
|
[
{
"ade": "Withdrawal emergent syndrome",
"drug": "haloperidol"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Withdrawal emergent syndrome in an infant associated with maternal haloperidol therapy.",
"role": "user"
},
{
"content": "[{'ade': 'Withdrawal emergent syndrome', 'drug': 'haloperidol'}]",
"role": "assistant"
}
] |
Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.
|
[
{
"ade": "aplastic anemia",
"drug": "gold"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia.",
"role": "user"
},
{
"content": "[{'ade': 'aplastic anemia', 'drug': 'gold'}]",
"role": "assistant"
}
] |
Aliskiren-associated acute renal failure with hyperkalemia.
|
[
{
"ade": "acute renal failure",
"drug": "Aliskiren"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Aliskiren-associated acute renal failure with hyperkalemia.",
"role": "user"
},
{
"content": "[{'ade': 'acute renal failure', 'drug': 'Aliskiren'}]",
"role": "assistant"
}
] |
Lower extremity arterial insufficiency after long-term methysergide maleate therapy.
|
[
{
"ade": "arterial insufficiency",
"drug": "methysergide maleate"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Lower extremity arterial insufficiency after long-term methysergide maleate therapy.",
"role": "user"
},
{
"content": "[{'ade': 'arterial insufficiency', 'drug': 'methysergide maleate'}]",
"role": "assistant"
}
] |
Hepatotoxicity related to itraconazole: report of three cases.
|
[
{
"ade": "Hepatotoxicity",
"drug": "itraconazole"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Hepatotoxicity related to itraconazole: report of three cases.",
"role": "user"
},
{
"content": "[{'ade': 'Hepatotoxicity', 'drug': 'itraconazole'}]",
"role": "assistant"
}
] |
We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.
|
[
{
"ade": "mild hypotension",
"drug": "pilocarpine"
},
{
"ade": "muscarinic symptoms",
"drug": "pilocarpine"
},
{
"ade": "bradycardia",
"drug": "pilocarpine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report a case of unintentional overdose of oral pilocarpine tablets that resulted in bradycardia, mild hypotension, and muscarinic symptoms in a patient with Sjogren's syndrome.",
"role": "user"
},
{
"content": "[{'ade': 'mild hypotension', 'drug': 'pilocarpine'}, {'ade': 'muscarinic symptoms', 'drug': 'pilocarpine'}, {'ade': 'bradycardia', 'drug': 'pilocarpine'}]",
"role": "assistant"
}
] |
We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.
|
[
{
"ade": "eosinophilic cystitis",
"drug": "dimethyl sulfoxide"
},
{
"ade": "eosinophilic cystitis",
"drug": "DMSO"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We report the first case of an acute flare of eosinophilic cystitis in a 51-year-old woman after bladder instillation with dimethyl sulfoxide (DMSO) for presumed interstitial cystitis.",
"role": "user"
},
{
"content": "[{'ade': 'eosinophilic cystitis', 'drug': 'dimethyl sulfoxide'}, {'ade': 'eosinophilic cystitis', 'drug': 'DMSO'}]",
"role": "assistant"
}
] |
OBJECTIVE: To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.
|
[
{
"ade": "neutropenia",
"drug": "vancomycin"
},
{
"ade": "neutropenia",
"drug": "teicoplanin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: OBJECTIVE: To report teicoplanin-related neutropenia that developed after an episode of neutropenia induced by vancomycin therapy.",
"role": "user"
},
{
"content": "[{'ade': 'neutropenia', 'drug': 'vancomycin'}, {'ade': 'neutropenia', 'drug': 'teicoplanin'}]",
"role": "assistant"
}
] |
Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.
|
[
{
"ade": "cerebrospinal fluid eosinophilia",
"drug": "vancomycin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Intraventricular vancomycin-induced cerebrospinal fluid eosinophilia: report of two patients.",
"role": "user"
},
{
"content": "[{'ade': 'cerebrospinal fluid eosinophilia', 'drug': 'vancomycin'}]",
"role": "assistant"
}
] |
We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.
|
[
{
"ade": "stroke",
"drug": "PPA"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We present a case of stroke after PPA ingestion that occurred 4 months after the recall in an 8-year-old boy on chronic peritoneal dialysis.",
"role": "user"
},
{
"content": "[{'ade': 'stroke', 'drug': 'PPA'}]",
"role": "assistant"
}
] |
We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.
|
[
{
"ade": "ulcerative proctitis",
"drug": "ibuprofen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We describe a case of ulcerative proctitis after ibuprofen treatment in a girl with juvenile systemic lupus erythematosus.",
"role": "user"
},
{
"content": "[{'ade': 'ulcerative proctitis', 'drug': 'ibuprofen'}]",
"role": "assistant"
}
] |
CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.
|
[
{
"ade": "worsening of chronic aphthous ulcers",
"drug": "tacrolimus"
},
{
"ade": "worsening of chronic aphthous ulcers",
"drug": "sirolimus"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CASE: We present an 11-year old male with Budd-Chiari syndrome who experienced profound worsening of chronic aphthous ulcers after immunosuppressive therapy was changed from tacrolimus to sirolimus.",
"role": "user"
},
{
"content": "[{'ade': 'worsening of chronic aphthous ulcers', 'drug': 'tacrolimus'}, {'ade': 'worsening of chronic aphthous ulcers', 'drug': 'sirolimus'}]",
"role": "assistant"
}
] |
Linear IgA bullous dermatosis occurring after carbamazepine.
|
[
{
"ade": "Linear IgA bullous dermatosis",
"drug": "carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Linear IgA bullous dermatosis occurring after carbamazepine.",
"role": "user"
},
{
"content": "[{'ade': 'Linear IgA bullous dermatosis', 'drug': 'carbamazepine'}]",
"role": "assistant"
}
] |
We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.
|
[
{
"ade": "panhypogammaglobulinaemia",
"drug": "prednisolone"
},
{
"ade": "panhypogammaglobulinaemia",
"drug": "cyclophosphamide"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We observed transient panhypogammaglobulinaemia in a patient with neuropsychiatric SLE after treatment with prednisolone and cyclophosphamide.",
"role": "user"
},
{
"content": "[{'ade': 'panhypogammaglobulinaemia', 'drug': 'prednisolone'}, {'ade': 'panhypogammaglobulinaemia', 'drug': 'cyclophosphamide'}]",
"role": "assistant"
}
] |
The patient was found to have no motile sperm with a normal sperm count, while taking a dose of 400 mg/day of carbamazepine.
|
[
{
"ade": "no motile sperm",
"drug": "carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The patient was found to have no motile sperm with a normal sperm count, while taking a dose of 400 mg/day of carbamazepine.",
"role": "user"
},
{
"content": "[{'ade': 'no motile sperm', 'drug': 'carbamazepine'}]",
"role": "assistant"
}
] |
The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented.
|
[
{
"ade": "exacerbating OCS",
"drug": "quetiapine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The first known report of quetiapine exacerbating OCS in a 43-year-old man with obsessive-compulsive disorder (OCD), trichotillomania, delusional disorder and bipolar II disorder is presented.",
"role": "user"
},
{
"content": "[{'ade': 'exacerbating OCS', 'drug': 'quetiapine'}]",
"role": "assistant"
}
] |
This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coronary vasospasm.
|
[
{
"ade": "refractory coronary vasospasm",
"drug": "cocaine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: This case report illustrates the use of continuous high-dose intracoronary nitroglycerin infusion through a 6 French coronary guiding catheter in the treatment of a patient with cocaine-induced refractory coronary vasospasm.",
"role": "user"
},
{
"content": "[{'ade': 'refractory coronary vasospasm', 'drug': 'cocaine'}]",
"role": "assistant"
}
] |
Generalized argyria after habitual use of AgNO3.
|
[
{
"ade": "Generalized argyria",
"drug": "AgNO3"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Generalized argyria after habitual use of AgNO3.",
"role": "user"
},
{
"content": "[{'ade': 'Generalized argyria', 'drug': 'AgNO3'}]",
"role": "assistant"
}
] |
Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour.
|
[
{
"ade": "significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons",
"drug": "HAL"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Animals treated with HAL showed a highly significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons in the substantia nigra, and 20% contraction of the TH stained dendritic arbour.",
"role": "user"
},
{
"content": "[{'ade': 'significant 32%-46% loss of tyrosine hydroxylase (TH) immunoreactive neurons', 'drug': 'HAL'}]",
"role": "assistant"
}
] |
Central nervous system toxicity associated with meperidine use in hepatic disease.
|
[
{
"ade": "Central nervous system toxicity",
"drug": "meperidine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Central nervous system toxicity associated with meperidine use in hepatic disease.",
"role": "user"
},
{
"content": "[{'ade': 'Central nervous system toxicity', 'drug': 'meperidine'}]",
"role": "assistant"
}
] |
CONCLUSION: Long-term treatment with rifabutin may have a reversible and previously undescribed side-effect on retinal function.
|
[
{
"ade": "side-effect on retinal function",
"drug": "rifabutin"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: CONCLUSION: Long-term treatment with rifabutin may have a reversible and previously undescribed side-effect on retinal function.",
"role": "user"
},
{
"content": "[{'ade': 'side-effect on retinal function', 'drug': 'rifabutin'}]",
"role": "assistant"
}
] |
The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.
|
[
{
"ade": "multiple myeloma",
"drug": "DILANTIN"
},
{
"ade": "multiple myeloma",
"drug": "diphenylhydantoin"
},
{
"ade": "IgG lambda-type monoclonal gammopathy",
"drug": "diphenylhydantoin"
},
{
"ade": "IgG lambda-type monoclonal gammopathy",
"drug": "DILANTIN"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: The development of an IgG lambda-type monoclonal gammopathy and subsequent multiple myeloma in an epilepsy patient on diphenylhydantoin (DILANTIN) therapy for 20 years is reported.",
"role": "user"
},
{
"content": "[{'ade': 'multiple myeloma', 'drug': 'DILANTIN'}, {'ade': 'multiple myeloma', 'drug': 'diphenylhydantoin'}, {'ade': 'IgG lambda-type monoclonal gammopathy', 'drug': 'diphenylhydantoin'}, {'ade': 'IgG lambda-type monoclonal gammopathy', 'drug': 'DILANTIN'}]",
"role": "assistant"
}
] |
L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.
|
[
{
"ade": "pancreatitis",
"drug": "L-asparaginase"
},
{
"ade": "lethal complication",
"drug": "L-asparaginase"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: L-asparaginase-induced pancreatitis is an uncommon but potential lethal complication of the treatment of leukemia.",
"role": "user"
},
{
"content": "[{'ade': 'pancreatitis', 'drug': 'L-asparaginase'}, {'ade': 'lethal complication', 'drug': 'L-asparaginase'}]",
"role": "assistant"
}
] |
We believe the temporal association of the abnormal liver enzymes in this patient, in the absence of other offending agents, argues strongly in favor of 6-TG as a cause of liver enzyme abnormalities.
|
[
{
"ade": "abnormal liver enzymes",
"drug": "6-TG"
},
{
"ade": "liver enzyme abnormalities",
"drug": "6-TG"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: We believe the temporal association of the abnormal liver enzymes in this patient, in the absence of other offending agents, argues strongly in favor of 6-TG as a cause of liver enzyme abnormalities.",
"role": "user"
},
{
"content": "[{'ade': 'abnormal liver enzymes', 'drug': '6-TG'}, {'ade': 'liver enzyme abnormalities', 'drug': '6-TG'}]",
"role": "assistant"
}
] |
BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.
|
[
{
"ade": "teratogenic",
"drug": "Accutane"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: BACKGROUND: Accutane a teratogenic prescription drug licensed to treat severe, recalcitrant nodular acne.",
"role": "user"
},
{
"content": "[{'ade': 'teratogenic', 'drug': 'Accutane'}]",
"role": "assistant"
}
] |
Systemic allergic contact dermatitis to 8-methoxypsoralen (8-MOP).
|
[
{
"ade": "Systemic allergic contact dermatitis",
"drug": "8-MOP"
},
{
"ade": "Systemic allergic contact dermatitis",
"drug": "8-methoxypsoralen"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Systemic allergic contact dermatitis to 8-methoxypsoralen (8-MOP).",
"role": "user"
},
{
"content": "[{'ade': 'Systemic allergic contact dermatitis', 'drug': '8-MOP'}, {'ade': 'Systemic allergic contact dermatitis', 'drug': '8-methoxypsoralen'}]",
"role": "assistant"
}
] |
Diabetes Mellitus was observed in a patient given carbamazepine.
|
[
{
"ade": "Diabetes Mellitus",
"drug": "carbamazepine"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Diabetes Mellitus was observed in a patient given carbamazepine.",
"role": "user"
},
{
"content": "[{'ade': 'Diabetes Mellitus', 'drug': 'carbamazepine'}]",
"role": "assistant"
}
] |
Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.
|
[
{
"ade": "Bronchiolitis obliterans with organizing pneumonia",
"drug": "rituximab"
}
] |
[
{
"content": "Analyze the sentence and extract all relationships between drugs and their adverse drug effects (ADEs). Each sentence may contain multiple drug-ADE pairs. <sentence>: Bronchiolitis obliterans with organizing pneumonia after rituximab therapy for non-Hodgkin's lymphoma.",
"role": "user"
},
{
"content": "[{'ade': 'Bronchiolitis obliterans with organizing pneumonia', 'drug': 'rituximab'}]",
"role": "assistant"
}
] |
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