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Skin necrosis is a rare complication of subcutaneous heparin therapy that usually occurs at injection sites.
[ { "ade": "Skin necrosis", "drug": "heparin" } ]
A 44-year-old woman is described in whom amiodarone, disopyramide, and quinidine, administered alone separately, induced atypical ventricular tachycardia (AVT, torsade de pointes).
[ { "ade": "AVT", "drug": "quinidine" }, { "ade": "AVT", "drug": "disopyramide" }, { "ade": "torsade de pointes", "drug": "quinidine" }, { "ade": "atypical ventricular tachycardia", "drug": "quinidine" }, { "ade": "AVT", "drug": "amiodarone" }, { "ade": "torsade de pointes", "drug": "amiodarone" }, { "ade": "atypical ventricular tachycardia", "drug": "disopyramide" }, { "ade": "atypical ventricular tachycardia", "drug": "amiodarone" }, { "ade": "torsade de pointes", "drug": "disopyramide" } ]
A patient with severe cholestatic jaundice induced by captopril is presented.
[ { "ade": "severe cholestatic jaundice", "drug": "captopril" } ]
Four days after the initial injection of 3.6 mg of goserelin acetate, severe dyspnea developed due to worsening pleuritis carcinomatosa, which was considered as a flare-up.
[ { "ade": "flare-up", "drug": "goserelin acetate" }, { "ade": "worsening pleuritis carcinomatosa", "drug": "goserelin acetate" }, { "ade": "severe dyspnea", "drug": "goserelin acetate" } ]
After stopping indapamide, glucose tolerance impairing may be reversed.
[ { "ade": "glucose tolerance impairing", "drug": "indapamide" } ]
Intrathecal methotrexate-induced acute cerebellar syndrome.
[ { "ade": "acute cerebellar syndrome", "drug": "methotrexate" } ]
We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.
[ { "ade": "parkinsonism", "drug": "metoclopramide" } ]
Three patients are reported without a history of angina pectoris who had clinical and electrocardiographic evidence of myocardial ischemia during and immediately after BCNU infusion.
[ { "ade": "myocardial ischemia", "drug": "BCNU" } ]
Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia and thrombocytopenia.
[ { "ade": "thrombocytopenia", "drug": "IFN" }, { "ade": "hypoalbuminemia", "drug": "IFN" }, { "ade": "ocular side effects", "drug": "IFN" } ]
Both the longitudinal melanonychia and the multiple skin cancers first appeared after approximately 6 months of hydroxyurea treatment.
[ { "ade": "multiple skin cancers", "drug": "hydroxyurea" }, { "ade": "longitudinal melanonychia", "drug": "hydroxyurea" } ]
Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus.
[ { "ade": "cortical negative myoclonus", "drug": "pregabalin" } ]
The authors describe a woman with chronic schizophrenia who experienced delirium, grand mal seizure, and photosensitivity after the addition of propranolol to her neuroleptic regimen.
[ { "ade": "grand mal seizure", "drug": "propranolol" }, { "ade": "photosensitivity", "drug": "propranolol" }, { "ade": "delirium", "drug": "propranolol" } ]
Thus, we confirm that desensitization may be a safe procedure in patients with cancer who experience methotrexate-induced anaphylaxis.
[ { "ade": "anaphylaxis", "drug": "methotrexate" } ]
Amphotericin B nephrotoxicity in humans decreased by salt repletion.
[ { "ade": "nephrotoxicity", "drug": "Amphotericin B" } ]
Adverse effects of amiodarone including pulmonary toxicity, hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well understood.
[ { "ade": "hepatotoxicity", "drug": "amiodarone" }, { "ade": "aggravation of arrhythmia", "drug": "amiodarone" }, { "ade": "pulmonary toxicity", "drug": "amiodarone" }, { "ade": "thyroid diseases", "drug": "amiodarone" } ]
A 51-year old physically fit woman experienced angio-oedema and hypotensive shock after irbesartan ingestion requiring noradrenaline infusion.
[ { "ade": "angio-oedema", "drug": "irbesartan" }, { "ade": "hypotensive shock", "drug": "irbesartan" } ]
In three of these patients the infection was clinically unsuspected; in the fourth, cutaneous herpes zoster developed after administration of 300 mg of cytarabine daily for the preceding five days.
[ { "ade": "cutaneous herpes zoster", "drug": "cytarabine" } ]
We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma.
[ { "ade": "choroidal detachment", "drug": "dorzolamide" } ]
After reviewing the literature we suggest the CPM was a complication of lithium toxicity which affected the lateral geniculate nucleus which produced blindness.
[ { "ade": "blindness", "drug": "lithium" }, { "ade": "CPM", "drug": "lithium" } ]
The patient was positive for antibody against complexes of heparin and platelet factor 4, and was diagnosed as heparin-induced thrombocytopenia with thrombosis syndrome (HITTS).
[ { "ade": "thrombosis syndrome", "drug": "heparin" }, { "ade": "thrombocytopenia", "drug": "heparin" } ]
Delayed pseudocyst of the pancreas can be a complication of intramuscular L-asparaginase.
[ { "ade": "Delayed pseudocyst of the pancreas", "drug": "L-asparaginase" } ]
Captopril-induced acute reversible renal failure.
[ { "ade": "acute reversible renal failure", "drug": "Captopril" } ]
Sulindac (Clinoril), a nonsteroidal anti-inflammatory agent, has few reported neurologic toxic effects, all of which have been associated with systemic disease.
[ { "ade": "neurologic toxic effects", "drug": "Sulindac" }, { "ade": "neurologic toxic effects", "drug": "Clinoril" } ]
Acute leukopenia associated with silver sulfadiazine therapy.
[ { "ade": "Acute leukopenia", "drug": "silver sulfadiazine" } ]
Intranasal desmopressin-induced hyponatremia.
[ { "ade": "hyponatremia", "drug": "desmopressin" } ]
While the mechanism of dextran-associated renal failure remains unsolved, plasma exchange seems to be effective therapy.
[ { "ade": "renal failure", "drug": "dextran" } ]
Nine eyes from 6 patients, 74 years to 90 years of age, referred by ophthalmologists for repair of cicatricial entropion after at least 2 years of twice-a-day application of dipivefrin.
[ { "ade": "cicatricial entropion", "drug": "dipivefrin" } ]
Methemoglobinemia is another common finding among patients receiving dapsone therapy, but rarely does it result in prominent symptoms other than transient pallor.
[ { "ade": "Methemoglobinemia", "drug": "dapsone" } ]
Isoniazid and ethambutol as a cause of optic neuropathy.
[ { "ade": "optic neuropathy", "drug": "Isoniazid" }, { "ade": "optic neuropathy", "drug": "ethambutol" } ]
We report the first case of fulminant adult respiratory distress syndrome (ARDS) associated with pegylated interferon alpha-2a (pegIFNalpha-2a) and ribavirin use for hepatitis C, complicated by subsequent and ultimately fatal sepsis and multiorgan failure.
[ { "ade": "ARDS", "drug": "pegylated interferon alpha-2a" }, { "ade": "ARDS", "drug": "pegIFNalpha-2a" }, { "ade": "ARDS", "drug": "ribavirin" }, { "ade": "adult respiratory distress syndrome", "drug": "ribavirin" }, { "ade": "adult respiratory distress syndrome", "drug": "pegylated interferon alpha-2a" }, { "ade": "adult respiratory distress syndrome", "drug": "pegIFNalpha-2a" } ]
OBJECTIVE: To test the hypothesis that tumor necrosis factor (TNF)-alpha may mediate the loss and the dedifferentiation of subcutaneous fat tissue in the insulin-induced lipoatrophies of a diabetic patient who presented extensive lesions.
[ { "ade": "lipoatrophies", "drug": "insulin" } ]
Nephropathy caused by methicillin therapy for staphylococcal septicemia.
[ { "ade": "Nephropathy", "drug": "methicillin" } ]
PURPOSE: To report a case of severe corticosteroid-induced glaucoma after intravitreal injection of triamcinolone acetate in a 34-year-old man without a history of glaucoma.
[ { "ade": "glaucoma", "drug": "triamcinolone acetate" }, { "ade": "glaucoma", "drug": "corticosteroid" } ]
Four patients who manifested symptoms of the antiepileptic drug (AED) hypersensitivity syndrome during therapy with carbamazepine are reported.
[ { "ade": "hypersensitivity syndrome", "drug": "carbamazepine" } ]
In these patients, long-acting octreotide may trigger serious hypoglycemia.
[ { "ade": "serious hypoglycemia", "drug": "octreotide" } ]
This is the first report of UFT-induced scleroderma-like reaction.
[ { "ade": "UFT-induced scleroderma-like reaction", "drug": "UFT" } ]
We report a case of penile fibrosis after intracavernous self-injection of a combination of phentolamine and papaverine.
[ { "ade": "penile fibrosis", "drug": "papaverine" }, { "ade": "penile fibrosis", "drug": "phentolamine" } ]
CONCLUSIONS: There was a temporal relationship between the onset of nonconvulsive status epilepticus and initiation of ifosfamide infusion.
[ { "ade": "nonconvulsive status epilepticus", "drug": "ifosfamide" } ]
Phenolphthalein-induced toxic epidermal necrolysis.
[ { "ade": "toxic epidermal necrolysis", "drug": "Phenolphthalein" } ]
The ampicillin rash occurring in cases of infectious mononucleosis is well documented.
[ { "ade": "ampicillin rash", "drug": "ampicillin" } ]
We also describe a case of timolol-induced ocular pemphigoid.
[ { "ade": "ocular pemphigoid", "drug": "timolol" } ]
Traumatic late flap dehiscence and Enterobacter keratitis following LASIK.
[ { "ade": "Traumatic late flap dehiscence", "drug": "LASIK" }, { "ade": "Enterobacter keratitis", "drug": "LASIK" } ]
Contrary to previous recommendations, our experience cautions against the further use of high-dose cytarabine in patients who develop PPE, and is a timely reminder of the potential toxicity of this agent, which is now increasingly being used as first-line treatment in the management of haematologic malignancies.
[ { "ade": "PPE", "drug": "cytarabine" } ]
After 5-ASA was discontinued, the polyneuropathy symptoms recovered gradually.
[ { "ade": "polyneuropathy", "drug": "5-ASA" } ]
Additionally, danazol produces hepatocellular damage in approximately 10% of women.
[ { "ade": "hepatocellular damage", "drug": "danazol" } ]
There is no consensus on the treatment of ticlopidine-induced marrow aplasia.
[ { "ade": "marrow aplasia", "drug": "ticlopidine" } ]
Piloerection induced by replacing fluvoxamine with milnacipran.
[ { "ade": "Piloerection", "drug": "fluvoxamine" }, { "ade": "Piloerection", "drug": "milnacipran" } ]
We describe a 43-year-old man who developed signs and symptoms of bilateral optic neuropathy during treatment with ethambutol.
[ { "ade": "bilateral optic neuropathy", "drug": "ethambutol" } ]
We report a case of pediatric bupropion ingestion resulting in multiple seizures.
[ { "ade": "multiple seizures", "drug": "bupropion" } ]
Lethal anuria complicating high dose ifosfamide chemotherapy in a breast cancer patient with an impaired renal function.
[ { "ade": "Lethal anuria", "drug": "ifosfamide" } ]
Lichen planus induced by hepatitis B vaccination: a new case and review of the literature.
[ { "ade": "Lichen planus", "drug": "hepatitis B vaccination" } ]
Paraplegia following intrathecal cytosine arabinoside.
[ { "ade": "Paraplegia", "drug": "cytosine arabinoside" } ]
Primary central nervous system lymphoma in a patient treated with natalizumab.
[ { "ade": "Primary central nervous system lymphoma", "drug": "natalizumab" } ]
Although risk factors for MTX-induced pulmonary toxicity are poorly understood, the presence in 3 out of 5 of our patients of pre-existing lung disease, represented by diffuse interstitial changes on chest X-ray, and mild bronchial asthma in two RA patients and by pulmonary silicosis in the patient with PsA may account for a predisposition to the development of MTX pneumonitis.
[ { "ade": "pulmonary toxicity", "drug": "MTX" }, { "ade": "pneumonitis", "drug": "MTX" } ]
At the end of his fifth cycle of sunitinib therapy, the patient complained of the development of abnormally large mammary glands associated with pain and peri-areolar erythema.
[ { "ade": "pain", "drug": "sunitinib" }, { "ade": "development of abnormally large mammary glands", "drug": "sunitinib" }, { "ade": "peri-areolar erythema", "drug": "sunitinib" } ]
A 62-year-old Caucasian man with atrial fibrillation who was taking warfarin reported an episode of hematochezia; his international normalized ratio (INR) was 1.74.
[ { "ade": "hematochezia", "drug": "warfarin" } ]
Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.
[ { "ade": "thrombocytopenia", "drug": "heparin" }, { "ade": "Massive pulmonary embolism", "drug": "heparin" } ]
Portal vein thrombosis in a patient with severe haemophilia A and F V G1691A mutation during continuous infusion of F VIII after intramural jejunal bleeding--successful thrombolysis under heparin therapy.
[ { "ade": "Portal vein thrombosis", "drug": "F VIII" } ]
CONCLUSIONS: Spontaneous hemothorax is a rare phenomenon in conjunction with LMWH but should be considered in cases of acute respiratory distress following commencement of LMWH.
[ { "ade": "Spontaneous hemothorax", "drug": "LMWH" } ]
We report the case of a patient with chronic lymphocytic leukemia (CLL) who developed fatal intravascular autoimmune hemolytic anemia (AIHA) after fludarabine treatment.
[ { "ade": "fatal intravascular autoimmune hemolytic anemia", "drug": "fludarabine" }, { "ade": "AIHA", "drug": "fludarabine" } ]
Photo-onycholysis caused by olanzapine and aripiprazole.
[ { "ade": "Photo-onycholysis", "drug": "olanzapine" }, { "ade": "Photo-onycholysis", "drug": "aripiprazole" } ]
Four days after intravenous Zoledronic acid, the patient presented to emergency room with complaints of carpopedal spasm and bronchospasm.
[ { "ade": "bronchospasm", "drug": "Zoledronic acid" }, { "ade": "carpopedal spasm", "drug": "Zoledronic acid" } ]
The potential development of SJS/TEN, a severe life-threatening illness, emphasizes the need for judicious use of TMP-Sx and close monitoring and follow-up for patients who were given TMP-Sx for SSTIs.
[ { "ade": "TEN", "drug": "TMP-Sx" }, { "ade": "SJS", "drug": "TMP-Sx" } ]
Nephrogenic diabetes insipidus (NDI) is a well-documented complication of lithium use.
[ { "ade": "Nephrogenic diabetes insipidus", "drug": "lithium" }, { "ade": "NDI", "drug": "lithium" } ]
Bleomycin and cyclophosphamide toxicity simulating metastatic nodules to the lungs in childhood cancer.
[ { "ade": "metastatic nodules", "drug": "cyclophosphamide" }, { "ade": "metastatic nodules", "drug": "Bleomycin" } ]
A new type of minocycline-induced cutaneous hyperpigmentation.
[ { "ade": "cutaneous hyperpigmentation", "drug": "minocycline" } ]
So far, few cases of pulmonary side effects caused by ticlopidine have been reported.
[ { "ade": "pulmonary side effects", "drug": "ticlopidine" } ]
As this relapse coincided with development of a strong delayed-type hypersensitivity response to tuberculin and improved after treatment with the anti-inflammatory agent oxpentifylline, it was probably caused by restoration of pathogen-specific cellular immunity.
[ { "ade": "hypersensitivity response", "drug": "tuberculin" } ]
The findings were judged to be consistent with soft-tissue injury associated with intravenous administration of phenytoin, also termed purple glove syndrome.
[ { "ade": "soft-tissue injury", "drug": "phenytoin" }, { "ade": "purple glove syndrome", "drug": "phenytoin" } ]
After rechallenge with monotherapy pegvisomant, however, the hepatic enzyme disturbances reappeared within a few weeks, indicating that most likely pegvisomant alone and not the long-acting somatostatin analog or the combination of these two drugs was responsible for this case of drug-induced hepatitis.
[ { "ade": "hepatitis", "drug": "pegvisomant" }, { "ade": "hepatic enzyme disturbances", "drug": "pegvisomant" } ]
This patient rapidly progressed from mild neurotoxicity to fatal encephalopathy after one dose of intrathecal methotrexate during his third cycle of chemotherapy.
[ { "ade": "fatal encephalopathy", "drug": "methotrexate" }, { "ade": "mild neurotoxicity", "drug": "methotrexate" } ]
Development of sarcoidosis during interferon alpha 2b and ribavirin combination therapy for chronic hepatitis C--a case report and review of the literature.
[ { "ade": "sarcoidosis", "drug": "ribavirin" }, { "ade": "sarcoidosis", "drug": "interferon alpha 2b" } ]
Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients.
[ { "ade": "Agranulocytosis", "drug": "vancomycin" } ]
Three months after starting citalopram, she experienced episodes of chest tightness and dizziness.
[ { "ade": "chest tightness", "drug": "citalopram" }, { "ade": "dizziness", "drug": "citalopram" } ]
While for ribavirin antidepressant effects are not known, we suppose that antidepressants may prevent changes in serotonergic or noradrenergic neurotransmission caused by IFN-alpha.
[ { "ade": "changes in serotonergic or noradrenergic neurotransmission", "drug": "IFN-alpha" } ]
This is an image and brief case report of a 13-year-old boy who presented with severe rash and systemic symptoms after starting oxcarbazepine.
[ { "ade": "severe rash", "drug": "oxcarbazepine" } ]
Reversible heart failure in a patient receiving etanercept for ankylosing spondylitis.
[ { "ade": "Reversible heart failure", "drug": "etanercept" } ]
A 66-year-old mand suffering from severe coronary heart disease took digoxin with suicidal intent an was treated for the ensuing complete atrioventricular block with digoxin-specific antibody fragments.
[ { "ade": "complete atrioventricular block", "drug": "digoxin" } ]
Severe C. difficile colitis occurred in 2 patients (6.1%) after receiving cisplatin-based combination chemotherapy for ovarian malignancies.
[ { "ade": "C. difficile colitis", "drug": "cisplatin" } ]
Metoclopramide-induced parkinsonism.
[ { "ade": "parkinsonism", "drug": "Metoclopramide" } ]
Acne provoked by gold seems not to have been described elsewhere.
[ { "ade": "Acne", "drug": "gold" } ]
A 54-year-old man developed TEN 4 weeks after beginning lamotrigine for complex partial seizures related to a glioblastoma multiforme brain tumor.
[ { "ade": "TEN", "drug": "lamotrigine" } ]
Two children, 1 with idiopathic nephrotic syndrome and 1 with endo-extracapillary glomerulonephritis, presented an episode of seizures and transient blindness at different times after i.v. pulse methylprednisolone (IVPMP) treatment.
[ { "ade": "seizures", "drug": "methylprednisolone" }, { "ade": "transient blindness", "drug": "methylprednisolone" } ]
A 62-year-old Indian with diabetic nephropathy controlled with metformin, developed miliary tuberculosis for which he was treated with rifampicin, isoniazid and ethambutol.
[ { "ade": "miliary tuberculosis", "drug": "metformin" } ]
Based on our experience and on previously published data, serum ammonia levels appear to be indicated in all ED patients on valproic acid therapy who present with altered mental status.
[ { "ade": "altered mental status", "drug": "valproic acid" } ]
Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.
[ { "ade": "aggravation of nonalcoholic steatohepatitis", "drug": "raloxifene" } ]
Nitrendipine-induced gingival hyperplasia.
[ { "ade": "gingival hyperplasia", "drug": "Nitrendipine" } ]
OBJECTIVE: To report a case of severe chloroquine toxicity in the presence of high-grade chloroquine-resistant Plasmodium vivax.
[ { "ade": "severe chloroquine toxicity", "drug": "chloroquine" } ]
Methanol toxicity can cause severe central nervous system insult in which a characteristic pattern of bilateral putaminal injury is noted on brain imaging studies.
[ { "ade": "Methanol toxicity", "drug": "Methanol" }, { "ade": "severe central nervous system insult", "drug": "Methanol" }, { "ade": "bilateral putaminal injury", "drug": "Methanol" } ]
This case illustrates that the hemophagocytic syndrome associated with reactivation of EBV can occur as part of drug hypersensitivity reactions in RA patients taking sulfasalazine.
[ { "ade": "hemophagocytic syndrome", "drug": "sulfasalazine" } ]
PURPOSE: To report two cases of acute endophthalmitis following intravitreal bevacizumab injection.
[ { "ade": "acute endophthalmitis", "drug": "bevacizumab" } ]
Erythema multiforme associated with phenytoin and cranial radiation therapy: a report of three patients and review of the literature.
[ { "ade": "Erythema multiforme", "drug": "phenytoin" } ]
The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma.
[ { "ade": "diffuse subfascial hematoma", "drug": "alteplase" }, { "ade": "cutaneous ecchymosis", "drug": "alteplase" }, { "ade": "sudden fall in hemoglobin", "drug": "alteplase" } ]
We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).
[ { "ade": "GPP", "drug": "Molipaxin" }, { "ade": "generalized pustular psoriasis", "drug": "Molipaxin" }, { "ade": "GPP", "drug": "trazodone hydrochloride" }, { "ade": "generalized pustular psoriasis", "drug": "trazodone hydrochloride" } ]
A patient developed papilloedema and hepatic dysfunction while being treated with perhexiline maleate.
[ { "ade": "hepatic dysfunction", "drug": "perhexiline maleate" }, { "ade": "papilloedema", "drug": "perhexiline maleate" } ]
Reflex sympathetic dystrophy syndrome in renal transplanted patients under immunosuppression with tacrolimus.
[ { "ade": "Reflex sympathetic dystrophy syndrome", "drug": "tacrolimus" } ]
Imidazoline intoxication due to overdose or accidental ingestion but also after normal therapeutic usage is frequent in children.
[ { "ade": "Imidazoline intoxication", "drug": "Imidazoline" } ]
Allergic contact dermatitis to compound tincture of benzoin.
[ { "ade": "Allergic contact dermatitis", "drug": "benzoin" } ]
The diagnosis was supported by the temporal course of renal deterioration during exposure to cefuroxime and improvement on its discontinuation; the pattern repeated with rechallenge.
[ { "ade": "renal deterioration", "drug": "cefuroxime" } ]
Cephalosporin-induced leukopenia following rechallenge with cefoxitin.
[ { "ade": "leukopenia", "drug": "Cephalosporin" } ]