text stringlengths 22 455 | relations listlengths 1 24 |
|---|---|
RESULTS: The patient, a 27-year-old married Japanese woman with borderline personality disorder, developed an increased libido with the administration of fluvoxamine. | [
{
"ade": "increased libido",
"drug": "fluvoxamine"
}
] |
Levofloxacin-induced toxic epidermal necrolysis in an elderly patient. | [
{
"ade": "toxic epidermal necrolysis",
"drug": "Levofloxacin"
}
] |
Cimetidine-induced fever. | [
{
"ade": "fever",
"drug": "Cimetidine"
}
] |
Secondary acute myeloid leukemia after etoposide therapy for haemophagocytic lymphohistiocytosis. | [
{
"ade": "acute myeloid leukemia",
"drug": "etoposide"
}
] |
The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment. | [
{
"ade": "subacute interstitial pneumonitis-related pulmonary fibrosis",
"drug": "docetaxel"
}
] |
The patient continued to have fever and autonomic instability without evidence of infection which entirely resolved within 24 hours of reinstitution of full preadmission dosing of oral baclofen. | [
{
"ade": "autonomic instability",
"drug": "baclofen"
},
{
"ade": "fever",
"drug": "baclofen"
}
] |
The exact mechanism of IVIG-associated acute renal failure remains unclear. | [
{
"ade": "acute renal failure",
"drug": "IVIG"
}
] |
Can magnesium sulfate therapy impact lactogenesis? | [
{
"ade": "lactogenesis",
"drug": "magnesium sulfate"
}
] |
Severe akathisia during olanzapine treatment of acute schizophrenia. | [
{
"ade": "Severe akathisia",
"drug": "olanzapine"
}
] |
Accelerated nodulosis during methotrexate therapy for juvenile rheumatoid arthritis. | [
{
"ade": "Accelerated nodulosis",
"drug": "methotrexate"
}
] |
A syndrome of increased affect in response to risperidone among patients with schizophrenia. | [
{
"ade": "syndrome of increased affect",
"drug": "risperidone"
}
] |
Development of an extensive skin rash following a single dose of MTX may be an early warning sign for life-threatening bone marrow aplasia. | [
{
"ade": "extensive skin rash",
"drug": "MTX"
}
] |
A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold. | [
{
"ade": "lichen planus",
"drug": "gold"
}
] |
Losartan-induced angioedema. | [
{
"ade": "angioedema",
"drug": "Losartan"
}
] |
With the negative viral serologies, the clinical picture was most consistent with an infectious mononucleosis-like syndrome produced by the minocycline ingestion. | [
{
"ade": "mononucleosis-like syndrome",
"drug": "minocycline"
}
] |
The observation of cutaneous vasculitis during administration of propylthiouracil suggested that clinical awareness of this complication should be of considerable importance. | [
{
"ade": "cutaneous vasculitis",
"drug": "propylthiouracil"
}
] |
We describe a patient who became hypothyroid while taking ferrous sulfate. | [
{
"ade": "hypothyroid",
"drug": "ferrous sulfate"
}
] |
Albeit rare among Western patients, such lithium-associated thyroid dysfunctions appeared to be more likely to occur in Hong Kong Chinese. | [
{
"ade": "thyroid dysfunctions",
"drug": "lithium"
}
] |
Stuttering priapism complicating warfarin therapy in a patient with protein C deficiency. | [
{
"ade": "Stuttering priapism",
"drug": "warfarin"
}
] |
Hypersensitivity reaction following chloramphenicol administration in a patient with typhoid fever. | [
{
"ade": "Hypersensitivity reaction",
"drug": "chloramphenicol"
}
] |
Concomitant administration of lithium with olanzapine may place patients at risk for NMS. | [
{
"ade": "NMS",
"drug": "olanzapine"
},
{
"ade": "NMS",
"drug": "lithium"
}
] |
After five and six weeks of continuous oral administration of methylprednisolone, the boys developed steroid diabetes. | [
{
"ade": "steroid diabetes",
"drug": "methylprednisolone"
}
] |
Acute lung injury associated with 5-fluorouracil and oxaliplatinum combined chemotherapy. | [
{
"ade": "Acute lung injury",
"drug": "oxaliplatinum"
},
{
"ade": "Acute lung injury",
"drug": "5-fluorouracil"
}
] |
Paradoxical ventricular tachycardia and fibrillation after intravenous bretylium therapy. | [
{
"ade": "fibrillation",
"drug": "bretylium"
},
{
"ade": "Paradoxical ventricular tachycardia",
"drug": "bretylium"
}
] |
Potential causes of methamphetamine-related keratitis can be divided into four categories resulting from (a) direct pharmacologic and physical effects of methamphetamine; (b) the toxic effects of diluting or "cutting" agents such as lidocaine and quinine; (c) effects related to the route of drug administration (intravenous, inhalation, smoking); and (d) manufacture-related effects of exposure to unintentional caustic contaminants in the final product. | [
{
"ade": "keratitis",
"drug": "methamphetamine"
},
{
"ade": "toxic effects",
"drug": "methamphetamine"
},
{
"ade": "toxic effects",
"drug": "lidocaine"
},
{
"ade": "keratitis",
"drug": "lidocaine"
},
{
"ade": "keratitis",
"drug": "quinine"
},
{
"ade": "toxic effects",
"drug": "quinine"
}
] |
In the third child, the tics ceased after CBZ discontinuation. | [
{
"ade": "tics",
"drug": "CBZ"
}
] |
The pro-arrhythmic effects of procainamide may be explained on the basis of both its vagolytic action on the atrioventricular node as well as by prolongation of refractoriness in the accessory pathway. | [
{
"ade": "pro-arrhythmic effects",
"drug": "procainamide"
}
] |
Atenolol induced memory impairment: a case report. | [
{
"ade": "memory impairment",
"drug": "Atenolol"
}
] |
We report the specifics of 12 cases of severe hypertension after the intraoperative use of topical phenylephrine, submucosal epinephrine, or both. | [
{
"ade": "severe hypertension",
"drug": "phenylephrine"
},
{
"ade": "severe hypertension",
"drug": "epinephrine"
}
] |
There was a clear relationship between restarting the Accutane and recurrence of the transient myopia. | [
{
"ade": "transient myopia",
"drug": "Accutane"
}
] |
Niflumic acid-induced skeletal fluorosis: iatrogenic disease or therapeutic perspective for osteoporosis? | [
{
"ade": "skeletal fluorosis",
"drug": "Niflumic acid"
}
] |
Acute coronary events following cisplatin-based chemotherapy. | [
{
"ade": "Acute coronary events",
"drug": "cisplatin"
}
] |
A case of polymyositis with dilated cardiomyopathy associated with interferon alpha treatment for hepatitis B. | [
{
"ade": "polymyositis",
"drug": "interferon alpha"
},
{
"ade": "dilated cardiomyopathy",
"drug": "interferon alpha"
}
] |
Musculoskeletal complaints were the presenting symptoms in four of 44 children (9%) treated for relapsed Wilms' tumors with ifosfamide, a derivative of cyclophosphamide. | [
{
"ade": "Musculoskeletal complaints",
"drug": "cyclophosphamide"
},
{
"ade": "Musculoskeletal complaints",
"drug": "ifosfamide"
}
] |
Posterior reversible encephalopathy syndrome (PRES) induced by cyclosporine use in a patient with collapsing focal glomeruloesclerosis. | [
{
"ade": "Posterior reversible encephalopathy syndrome",
"drug": "PRES"
},
{
"ade": "cyclosporine",
"drug": "PRES"
}
] |
Fulminant hepatitis associated with disulfiram. | [
{
"ade": "Fulminant hepatitis",
"drug": "disulfiram"
}
] |
We report four cases of sensorimotor axonal neuropathy in children aged 10-15 years, treated with thalidomide for myxopapillary ependymoma, Crohn's disease and recurrent giant aphthous ulceration. | [
{
"ade": "sensorimotor axonal neuropathy",
"drug": "thalidomide"
}
] |
We report a patient who developed spontaneous splenic infarction after the use of sumatriptan for the treatment of migraine headache. | [
{
"ade": "spontaneous splenic infarction",
"drug": "sumatriptan"
}
] |
CONCLUSION: To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature. | [
{
"ade": "colchicine intoxication",
"drug": "colchicine"
}
] |
After induction of general anesthesia and administration of a standard dose of intravenous esmolol hydrochloride, her cardiac rhythm progressed to asystole. | [
{
"ade": "asystole",
"drug": "esmolol hydrochloride"
}
] |
Perinatal vasoconstrictive renal insufficiency associated with maternal nimesulide use. | [
{
"ade": "renal insufficiency",
"drug": "nimesulide"
}
] |
Flucloxacillin-induced aplastic anaemia and liver failure. | [
{
"ade": "liver failure",
"drug": "Flucloxacillin"
},
{
"ade": "aplastic anaemia",
"drug": "Flucloxacillin"
}
] |
We present the first case (to our knowledge) of a potentially serious drug-drug interaction between zafirlukast and theophylline. | [
{
"ade": "drug-drug interaction",
"drug": "zafirlukast"
},
{
"ade": "drug-drug interaction",
"drug": "theophylline"
}
] |
Carbamazepine hypersensitivity syndrome is a rare, life-threatening condition. | [
{
"ade": "hypersensitivity syndrome",
"drug": "Carbamazepine"
}
] |
With itraconazole, hepatotoxic reactions have only very rarely been reported, and histologic data are lacking. | [
{
"ade": "hepatotoxic",
"drug": "itraconazole"
}
] |
The present study describes a patient who had unusual weight fluctuation under corticosteroid and psychotropic treatment such as mianserin and aripiprazole. | [
{
"ade": "unusual weight fluctuation",
"drug": "aripiprazole"
},
{
"ade": "unusual weight fluctuation",
"drug": "mianserin"
}
] |
A sixty-year-old woman with advanced breast cancer, previously treated with cisplatin, developed an irreversible lethal renal failure with anuria, the day after 5 g/m2 bolus ifosfamide. | [
{
"ade": "irreversible lethal renal failure",
"drug": "ifosfamide"
},
{
"ade": "anuria",
"drug": "ifosfamide"
}
] |
Pancreatitis has been noted to be a complication in 2-16% of patients undergoing treatment with L-asparaginase for a variety of pediatric neoplasms. | [
{
"ade": "Pancreatitis",
"drug": "L-asparaginase"
}
] |
Neutrophilic dermatoses in two children with idiopathic neutropenia: association with granulocyte colony-stimulating factor (G-CSF) therapy. | [
{
"ade": "Neutrophilic dermatoses",
"drug": "granulocyte colony-stimulating factor"
},
{
"ade": "Neutrophilic dermatoses",
"drug": "G-CSF"
}
] |
The female patient received clozapine in a daily dose of 400 mg, which induced agranulocytosis after 2 months. | [
{
"ade": "agranulocytosis",
"drug": "clozapine"
}
] |
Interstitial lung disease (ILD) related to therapy with the drug gefitinib has been well reported. | [
{
"ade": "Interstitial lung disease",
"drug": "gefitinib"
},
{
"ade": "ILD",
"drug": "gefitinib"
}
] |
The principle treatment for DPD-deficient patients with severe acute 5-FU reactions is supportive care; however, the administration of thymidine potentially may reverse severe 5-FU-induced neurologic symptoms such as encephalopathy and coma. | [
{
"ade": "coma",
"drug": "5-FU"
},
{
"ade": "encephalopathy",
"drug": "5-FU"
},
{
"ade": "neurologic symptoms",
"drug": "5-FU"
},
{
"ade": "severe acute 5-FU reactions",
"drug": "5-FU"
}
] |
However, peripheral neuropathy and bone marrow depression led to linezolid withdrawal in seven patients, and neuropathy may not be fully reversible in all patients. | [
{
"ade": "neuropathy",
"drug": "linezolid"
},
{
"ade": "peripheral neuropathy",
"drug": "linezolid"
},
{
"ade": "bone marrow depression",
"drug": "linezolid"
}
] |
A case of acute respiratory failure due to diaphragmatic weakness following adalimumab therapy for psoriasis is described. | [
{
"ade": "acute respiratory failure",
"drug": "adalimumab"
}
] |
The patient developed occipital infarcts and was found to have extremely elevated levels of PPA in his blood and dialysis fluid. | [
{
"ade": "occipital infarcts",
"drug": "PPA"
},
{
"ade": "extremely elevated levels of PPA",
"drug": "PPA"
}
] |
There remains a paucity of information pertaining to alternative anticoagulation strategies for use during cardiopulmonary bypass concomitant with heparin-induced thrombocytopenia, especially in children. | [
{
"ade": "thrombocytopenia",
"drug": "heparin"
}
] |
He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil. | [
{
"ade": "fever",
"drug": "chlorambucil"
},
{
"ade": "hypereosinophilia",
"drug": "chlorambucil"
},
{
"ade": "acute renal failure",
"drug": "chlorambucil"
},
{
"ade": "skin rash",
"drug": "chlorambucil"
}
] |
Four Chinese female patients who suffered from manic-depressive disorder and underlying autoimmune thyroiditis developed transient episodes of thyrotoxicosis during maintenance lithium therapy. | [
{
"ade": "thyrotoxicosis",
"drug": "lithium"
}
] |
We report a case of long lasting respiratory depression after intravenous administration of morphine to a 7 year old girl with haemolytic uraemic syndrome. | [
{
"ade": "respiratory depression",
"drug": "morphine"
}
] |
The occurrence of BMTN in two children treated with RA in our unit is unlikely to be coincidental. | [
{
"ade": "BMTN",
"drug": "RA"
}
] |
Oncologists supervising future clinical trials for lung cancer should be alert to the fact that sorafenib can potentially induce serious interstitial lung disease, although this might depend on racial differences. | [
{
"ade": "interstitial lung disease",
"drug": "sorafenib"
}
] |
Dipyrone-induced granulocytopenia: a case for awareness. | [
{
"ade": "granulocytopenia",
"drug": "Dipyrone"
}
] |
We report the case of a patient with increased cerebral cortical excitability following intoxication with flupirtine, a centrally acting analgesic and antispastic drug. | [
{
"ade": "increased cerebral cortical excitability",
"drug": "flupirtine"
}
] |
Central nervous system effects secondary to ciprofloxacin treatment are uncommon and usually consist only of minor dizziness or mild headache, although rare occurrences of seizures and hallucinations have been reported. | [
{
"ade": "minor dizziness",
"drug": "ciprofloxacin"
},
{
"ade": "mild headache",
"drug": "ciprofloxacin"
},
{
"ade": "seizures",
"drug": "ciprofloxacin"
},
{
"ade": "hallucinations",
"drug": "ciprofloxacin"
}
] |
Hyponatremia in patients treated with lorcainide, a new antiarrhythmic drug. | [
{
"ade": "Hyponatremia",
"drug": "lorcainide"
}
] |
Since the bronchospasm was relieved with discontinuation of propranolol and supportive bronchodilator therapy, the bronchospasm was believed to be caused by propranolol. | [
{
"ade": "bronchospasm",
"drug": "propranolol"
}
] |
Provocation of non-convulsive status epilepticus by tiagabine in three adolescent patients. | [
{
"ade": "non-convulsive status epilepticus",
"drug": "tiagabine"
}
] |
Stupor and fast activity on electroencephalography in a child treated with valproate. | [
{
"ade": "Stupor",
"drug": "valproate"
}
] |
We conclude peripheral neuropathy with 5-FU is rare. | [
{
"ade": "peripheral neuropathy",
"drug": "5-FU"
}
] |
OBJECTIVE: To report 2 cases of serotonin syndrome with serious extrapyramidal movement disorders occurring when metoclopramide was coadministered with sertraline or venlafaxine. | [
{
"ade": "serotonin syndrome",
"drug": "venlafaxine"
},
{
"ade": "extrapyramidal movement disorders",
"drug": "venlafaxine"
},
{
"ade": "extrapyramidal movement disorders",
"drug": "sertraline"
},
{
"ade": "serotonin syndrome",
"drug": "metoclopramide"
},
{
"ade": "extrapyramidal movement disorders",
"drug": "metoclopramide"
},
{
"ade": "serotonin syndrome",
"drug": "sertraline"
}
] |
Pericardial hemorrhage due to acetylsalicylic acid in a patient with essential thrombocythemia. | [
{
"ade": "Pericardial hemorrhage",
"drug": "acetylsalicylic acid"
}
] |
During and after IFN therapy we should consider the possibility of occurrence of IDDM as well as other autoimmune diseases and observe the clinical course carefully. | [
{
"ade": "IDDM",
"drug": "IFN"
}
] |
This report describes a case of flucytosine-associated ulcerating enteritis in which the small bowel x-ray demonstrated severe luminal narrowing, ulceration, and marked separation of loops of bowel. | [
{
"ade": "ulcerating enteritis",
"drug": "flucytosine"
},
{
"ade": "severe luminal narrowing",
"drug": "flucytosine"
},
{
"ade": "marked separation of loops of bowel",
"drug": "flucytosine"
},
{
"ade": "ulceration",
"drug": "flucytosine"
}
] |
A case of mania associated with fluoxetine. | [
{
"ade": "mania",
"drug": "fluoxetine"
}
] |
Primary CNS lymphoma complicating treatment of myasthenia gravis with mycophenolate mofetil. | [
{
"ade": "CNS lymphoma",
"drug": "mycophenolate mofetil"
}
] |
Severe hyperkalemia as a complication of timolol, a topically applied beta-adrenergic antagonist. | [
{
"ade": "Severe hyperkalemia",
"drug": "timolol"
}
] |
Goiter and hypothyroidism during re-treatment with amiodarone in a patient who previously experienced amiodarone-induced thyrotoxicosis. | [
{
"ade": "thyrotoxicosis",
"drug": "amiodarone"
},
{
"ade": "hypothyroidism",
"drug": "amiodarone"
},
{
"ade": "Goiter",
"drug": "amiodarone"
}
] |
This entity is probably related to a combination of high doses of corticosteroids, vecuronium administration and metabolic abnormalities associated with respiratory failure. | [
{
"ade": "respiratory failure",
"drug": "vecuronium"
}
] |
The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia. | [
{
"ade": "pericardial hemorrhage",
"drug": "acetylsalicylic acid"
}
] |
Hepatotoxic effects in a child receiving valproate and carnitine. | [
{
"ade": "Hepatotoxic effects",
"drug": "valproate"
},
{
"ade": "Hepatotoxic effects",
"drug": "carnitine"
}
] |
Patients from endemic areas referred to transplant centers may be at high risk for disseminated histoplasmosis when treated with long-term prednisone for graft-versus-host disease. | [
{
"ade": "disseminated histoplasmosis",
"drug": "prednisone"
}
] |
Although both patients recovered from the colitis after the administration of vancomycin, the first case demonstrated a relapse of the colitis after receiving a subsequent course of the same chemotherapy with cisplatin. | [
{
"ade": "colitis",
"drug": "cisplatin"
}
] |
A mentally retarded 23-year-old woman with myoclonic astatic epilepsy developed an abnormal posture of extreme forward flexion, called camptocormia, during valproate monotherapy. | [
{
"ade": "abnormal posture of extreme forward flexion",
"drug": "valproate"
},
{
"ade": "camptocormia",
"drug": "valproate"
}
] |
The cause of these previously unreported side effects of niacin therapy is uncertain but may be related to prostaglandin-mediated vasodilatation, hyperalgesia of sensory nerve receptors, and potentiation of inflammation in the gingiva with referral of pain to the teeth. | [
{
"ade": "pain to the teeth",
"drug": "niacin"
},
{
"ade": "prostaglandin-mediated vasodilatation",
"drug": "niacin"
},
{
"ade": "hyperalgesia of sensory nerve receptors",
"drug": "niacin"
},
{
"ade": "potentiation of inflammation in the gingiva",
"drug": "niacin"
}
] |
RESULTS: One case of recurrent primary peritoneal carcinoma previously treated with a carboplatin-based regimen, developed a platinum hypersensitivity. | [
{
"ade": "platinum hypersensitivity",
"drug": "carboplatin"
}
] |
We suggest discontinuing gemcitabine if radiation recall is observed. | [
{
"ade": "radiation recall",
"drug": "gemcitabine"
}
] |
She was placed on adjuvant Adriamycin (doxorubicin) chemotherapy, but 6 months later died of Adriamycin toxicity. | [
{
"ade": "died",
"drug": "doxorubicin"
},
{
"ade": "Adriamycin toxicity",
"drug": "doxorubicin"
},
{
"ade": "Adriamycin toxicity",
"drug": "Adriamycin"
},
{
"ade": "died",
"drug": "Adriamycin"
}
] |
Although isradipine has been associated with hepatocellular injury, there are no reports of fulminant liver failure with this agent, and our patient had been treated for >2 years without signs of toxicity. | [
{
"ade": "hepatocellular injury",
"drug": "isradipine"
}
] |
Penicillin-induced Jarisch-Herxheimer reaction. | [
{
"ade": "Jarisch-Herxheimer reaction",
"drug": "Penicillin"
}
] |
Two patients on long-term lithium therapy developed the nephrotic syndrome. | [
{
"ade": "nephrotic syndrome",
"drug": "lithium"
}
] |
In this article lithium is not discussed, although there are a number of concerns about lithium's potential teratogenicity, and it has been implicated in Epstein's anomaly, a congenital heart defect among infants born to women taking lithium; as with other medications, however, the data have specific limitations. | [
{
"ade": "teratogenicity",
"drug": "lithium"
},
{
"ade": "Epstein's anomaly",
"drug": "lithium"
}
] |
Proconvulsive tendency of imipenem/cilastatin is one of its well-known side effects. | [
{
"ade": "Proconvulsive",
"drug": "imipenem"
},
{
"ade": "Proconvulsive",
"drug": "cilastatin"
}
] |
Methylene blue in the treatment and prevention of ifosfamide-induced encephalopathy: report of 12 cases and a review of the literature. | [
{
"ade": "ifosfamide-induced encephalopathy",
"drug": "ifosfamide"
}
] |
We report a girl with the Rett syndrome who had acute encephalopathy probably induced by calcium hopantenate (HOPA). | [
{
"ade": "acute encephalopathy",
"drug": "HOPA"
},
{
"ade": "acute encephalopathy",
"drug": "calcium hopantenate"
}
] |
This is the first description, to our knowledge, of ductopenia apparently caused by clindamycin. | [
{
"ade": "ductopenia",
"drug": "clindamycin"
}
] |
We evaluated a patient who developed a psychotic disorder after 4 months of isoniazid prophylaxis for a positive tuberculosis tine test. | [
{
"ade": "psychotic disorder",
"drug": "isoniazid"
}
] |
In this report, two newborns with congenital heart anomalies demonstrated the harlequin color change, one whose skin findings showed a course related to the dose of systemic prostaglandin E1, suggesting a possible association. | [
{
"ade": "harlequin color change",
"drug": "prostaglandin E1"
}
] |
A patient with coccidioidal meningitis was treated with intrathecally administered amphotericin B, and an acute toxic delirium with EEG abnormalities developed. | [
{
"ade": "EEG abnormalities",
"drug": "amphotericin B"
},
{
"ade": "acute toxic delirium",
"drug": "amphotericin B"
}
] |
Severe neurotoxicity with methyl G: CALGB experience. | [
{
"ade": "Severe neurotoxicity",
"drug": "methyl G: CALGB"
}
] |
Falling backward in two elderly patients taking bupropion. | [
{
"ade": "Falling backward",
"drug": "bupropion"
}
] |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.