text stringlengths 22 455 | relations listlengths 1 24 |
|---|---|
Based on these findings, the patient was diagnosed with diabetes insipidus secondary to lithium therapy and was treated successfully with amiloride. | [
{
"ade": "diabetes insipidus",
"drug": "lithium"
}
] |
Mental nerve neuropathy as a result of hepatitis B vaccination. | [
{
"ade": "Mental nerve neuropathy",
"drug": "hepatitis B vaccination"
}
] |
Prick tests and intradermal tests with a series of dilutions of carboplatin and cisplatin were performed on three patients who had exhibited medium and severe hypersensitivity reactions to carboplatin. | [
{
"ade": "severe hypersensitivity",
"drug": "carboplatin"
}
] |
Possible induction of diabetes by treatment of hypertension with indapamide (with four case reports). | [
{
"ade": "diabetes",
"drug": "indapamide"
}
] |
The role of Adriamycin in the production of cardiotoxicity is reviewed. | [
{
"ade": "cardiotoxicity",
"drug": "Adriamycin"
}
] |
Growth and adrenal suppression in asthmatic children treated with high-dose fluticasone propionate. | [
{
"ade": "Growth and adrenal suppression",
"drug": "fluticasone propionate"
}
] |
Both patients developed hypoadrenalism while on o,p'-DDD and apparently adequate dexamethasone replacement therapy. | [
{
"ade": "hypoadrenalism",
"drug": "o,p'-DDD"
}
] |
A patient that received methadone for cancer-associated pain developed myoclonus as a side effect. | [
{
"ade": "myoclonus",
"drug": "methadone"
}
] |
In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine. | [
{
"ade": "severe systemic CMV infection",
"drug": "cyclosporine"
}
] |
OBJECTIVE: To report a case of colchicine-induced myopathy in a teenager with familial Mediterranean fever (FMF). | [
{
"ade": "myopathy",
"drug": "colchicine"
}
] |
Though physicians treating large populations of patients with HIV are well aware of this complication, only one other report of nevirapine-associated SJS has been documented in the dermatology literature. | [
{
"ade": "SJS",
"drug": "nevirapine"
}
] |
The international literature regarding opportunistic infections after immunosuppressive therapy with alemtuzumab with particular attention on fungal infections has also been reviewed. | [
{
"ade": "fungal infections",
"drug": "alemtuzumab"
},
{
"ade": "opportunistic infections",
"drug": "alemtuzumab"
}
] |
It is concluded that 'cerebral atrophy' on CT scans may represent an accumulative effect of ACTH and that ACTH should be given with the utmost discretion, and in as low a dose as possible. | [
{
"ade": "cerebral atrophy",
"drug": "ACTH"
}
] |
To our knowledge, these cases represent the first reports of TDF-associated irreversible renal failure and rickets in pediatric patients. | [
{
"ade": "irreversible renal failure",
"drug": "TDF"
},
{
"ade": "rickets",
"drug": "TDF"
}
] |
Diphenylhydantoin apparently adversely affected both the clinical and biochemical parameters of the acute intermittent porphyria. | [
{
"ade": "acute intermittent porphyria",
"drug": "Diphenylhydantoin"
}
] |
We introduce a case of a sixty years old woman with several previous episodes of rhinitis, conjunctivitis and perspiration immediately after the administration of salmon calcitonin with nasal spray or intramuscular administration (Calsynar). | [
{
"ade": "rhinitis",
"drug": "calcitonin"
},
{
"ade": "perspiration",
"drug": "calcitonin"
},
{
"ade": "conjunctivitis",
"drug": "Calsynar"
},
{
"ade": "conjunctivitis",
"drug": "calcitonin"
},
{
"ade": "rhinitis",
"drug": "Calsynar"
},
{
"ade": "perspiration",
"drug": "Calsynar"
}
] |
Caution in longterm usage and early recognition of pentazocine toxicity as a neuromuscular complication are important in order to prevent irreversible drug-induced fibrous myopathy and localized neuropathy. | [
{
"ade": "fibrous myopathy",
"drug": "pentazocine"
},
{
"ade": "neuromuscular complication",
"drug": "pentazocine"
},
{
"ade": "pentazocine toxicity",
"drug": "pentazocine"
},
{
"ade": "neuropathy",
"drug": "pentazocine"
}
] |
A case is described of severe splenic hemorrhage and rupture which developed 3 h after completion of tPA infusion for suspected acute myocardial infarction. | [
{
"ade": "severe splenic hemorrhage and rupture",
"drug": "tPA"
}
] |
Coadministration of antidepressant agents such as nefazodone, or any other drug that inhibits the CYP3A4 isoenzyme subfamily, should be anticipated to interfere with tacrolimus metabolism. | [
{
"ade": "interfere with tacrolimus metabolism",
"drug": "tacrolimus"
},
{
"ade": "interfere with tacrolimus metabolism",
"drug": "nefazodone"
}
] |
Although dyspnea associated with verapamil administration has been reported, this is the first report of an elderly asymptomatic asthmatic patient with hypertension who developed an acute asthma attack following sustained-release verapamil administration. | [
{
"ade": "dyspnea",
"drug": "verapamil"
},
{
"ade": "acute asthma",
"drug": "verapamil"
}
] |
On the other hand, MTX-induced pneumonitis seems to be very rare in psoriatic arthritis (PsA). | [
{
"ade": "pneumonitis",
"drug": "MTX"
}
] |
Three patients with no history of asthma or allergy developed bronchospasm while taking propranolol for hypertension. | [
{
"ade": "bronchospasm",
"drug": "propranolol"
}
] |
Two infants developed hyperkalemia shortly after cessation of prolonged ACTH therapy for infantile spasms. | [
{
"ade": "hyperkalemia",
"drug": "ACTH"
}
] |
A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment. | [
{
"ade": "hepatic angiosarcoma",
"drug": "cyclophosphamide"
}
] |
Sustained monomorphic ventricular tachycardia after adenosine infusion. | [
{
"ade": "Sustained monomorphic ventricular tachycardia",
"drug": "adenosine"
}
] |
An episode of leukoencephalopathy is reported in a 13-year-old girl who, after standard radiotherapy for a posterior fossa medulloblastoma, received 8 treatments with a protocol containing a 4-hour infusion of 500 mg/m2 methotrexate and 12 mg intrathecal methotrexate. | [
{
"ade": "leukoencephalopathy",
"drug": "methotrexate"
}
] |
Alveolar-interstitial pneumopathy after gold-salts compounds administration, requiring mechanical ventilation. | [
{
"ade": "Alveolar-interstitial pneumopathy",
"drug": "gold"
}
] |
Disseminated tuberculous lesions post intravesical BCG therapy are rare but need to be identified and treated quickly. | [
{
"ade": "Disseminated tuberculous lesions",
"drug": "BCG"
}
] |
The literature is also reviewed for ARF associated with mannitol infusion in patients who received dialysis and those who did not receive dialysis; and the possible mechanism(s) of mannitol nephrotoxicity are discussed. | [
{
"ade": "nephrotoxicity",
"drug": "mannitol"
},
{
"ade": "ARF",
"drug": "mannitol"
}
] |
Propoxyphene-induced wide complex dysrhythmia responsive to sodium bicarbonate therapy has not been previously reported in the literature. | [
{
"ade": "wide complex dysrhythmia",
"drug": "Propoxyphene"
}
] |
Sixteen hours after the first administration of IFN, IFN was suspended by the symptoms of congestive heart failure (CHF). | [
{
"ade": "CHF",
"drug": "IFN"
},
{
"ade": "congestive heart failure",
"drug": "IFN"
}
] |
We report on a patient who developed acute rhabdomyolysis after taking cerivastatin. | [
{
"ade": "acute rhabdomyolysis",
"drug": "cerivastatin"
}
] |
Four cases of fat embolism are described in infants receiving prolonged intravenous infusion of fat (Intralipid 20%). | [
{
"ade": "fat embolism",
"drug": "Intralipid"
}
] |
We present the case of an adult Crohn's disease patient with a parvovirus B19 infection and leukopenia during long-term AZA therapy. | [
{
"ade": "leukopenia",
"drug": "AZA"
}
] |
Acute renal failure during lisinopril and losartan therapy for proteinuria. | [
{
"ade": "Acute renal failure",
"drug": "losartan"
},
{
"ade": "Acute renal failure",
"drug": "lisinopril"
}
] |
A 23-year-old woman with systemic lupus erythematosus had a severe hypersensitivity reaction to the drug ibuprofen. | [
{
"ade": "severe hypersensitivity reaction",
"drug": "ibuprofen"
}
] |
Life-threatening acute hyponatraemia induced by low dose cyclophosphamide and indomethacin. | [
{
"ade": "acute hyponatraemia",
"drug": "indomethacin"
},
{
"ade": "acute hyponatraemia",
"drug": "cyclophosphamide"
}
] |
Multifocal inflammatory leukoencephalopathy associated with levamisole therapy. | [
{
"ade": "Multifocal inflammatory leukoencephalopathy",
"drug": "levamisole"
}
] |
Pharmacokinetic determinants of 6-mercaptopurine myelotoxicity and therapeutic failure in children with acute lymphoblastic leukemia. | [
{
"ade": "myelotoxicity",
"drug": "6-mercaptopurine"
}
] |
A 32-year-old man with a family history of type 2 diabetes mellitus presented with circulatory collapse and deep coma after 9 days of treatment with perospirone hydrochloride, a recently developed atypical antipsychotic agent available only in Japan. | [
{
"ade": "circulatory collapse",
"drug": "perospirone hydrochloride"
},
{
"ade": "deep coma",
"drug": "perospirone hydrochloride"
}
] |
CONCLUSIONS: Topiramate may be associated with ciliochoroidal effusion with forward displacement of the lens-iris diaphragm and anterior chamber shallowing, resulting in acute myopia and angle-closure glaucoma. | [
{
"ade": "angle-closure glaucoma",
"drug": "Topiramate"
},
{
"ade": "anterior chamber shallowing",
"drug": "Topiramate"
},
{
"ade": "displacement of the lens-iris diaphragm",
"drug": "Topiramate"
},
{
"ade": "acute myopia",
"drug": "Topiramate"
},
{
"ade": "ciliochoroidal effusion",
"drug": "Topiramate"
}
] |
An adult male presented with central blindness after ingesting methanol. | [
{
"ade": "central blindness",
"drug": "methanol"
}
] |
Their parkinsonism improved on discontinuation of metoclopramide therapy. | [
{
"ade": "parkinsonism",
"drug": "metoclopramide"
}
] |
Delay of corneal wound healing in patients treated with colchicine. | [
{
"ade": "Delay of corneal wound healing",
"drug": "colchicine"
}
] |
Cutaneous reactions to propylthiouracil and methimazole occur in 3%-5% of adults. | [
{
"ade": "Cutaneous reactions",
"drug": "methimazole"
},
{
"ade": "Cutaneous reactions",
"drug": "propylthiouracil"
}
] |
To our knowledge, these cases are the first published reports of lovastatin-induced rhabdomyolysis associated with azithromycin and clarithromycin. | [
{
"ade": "rhabdomyolysis",
"drug": "lovastatin"
},
{
"ade": "rhabdomyolysis",
"drug": "clarithromycin"
},
{
"ade": "rhabdomyolysis",
"drug": "azithromycin"
}
] |
We present here a female patient who developed acute bilateral parotitis within minutes of i.v. enalaprilat injection and recovered within 24 hours of stopping the drug and with symptomatic treatment. | [
{
"ade": "acute bilateral parotitis",
"drug": "enalaprilat"
}
] |
CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone. | [
{
"ade": "increase of INR",
"drug": "levamisole"
},
{
"ade": "increase of INR",
"drug": "5-FU"
},
{
"ade": "increase of INR",
"drug": "warfarin"
}
] |
In addition to disease refractoriness, rare instances of disease progression from chronic phase to blast crisis during imatinib therapy have recently been anecdotally reported. | [
{
"ade": "blast crisis",
"drug": "imatinib"
}
] |
Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin. | [
{
"ade": "hemorrhage",
"drug": "metformin"
}
] |
We describe a case of prolonged terbinafine-induced cholestatic liver disease. | [
{
"ade": "cholestatic liver disease",
"drug": "terbinafine"
}
] |
A 57-year-old man developed chronic, watery diarrhea four weeks after Helicobacter pylori eradication therapy including lansoprazole followed by lansoprazole monotherapy for gastroesophageal reflux disease. | [
{
"ade": "chronic, watery diarrhea",
"drug": "lansoprazole"
}
] |
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered. | [
{
"ade": "Gynecomastia",
"drug": "phenobarbital"
},
{
"ade": "Gynecomastia",
"drug": "fluoresone"
},
{
"ade": "Gynecomastia",
"drug": "phenytoin"
}
] |
Acute coronary syndromes can be associated with the infusion of rituximab. | [
{
"ade": "Acute coronary syndromes",
"drug": "rituximab"
}
] |
In this report we present four patients treated with a combination of different psychotropic drugs, in whom asterixis was triggered either by adding carbamazepine (CBZ) to a treatment regimen, or by increasing its dosage. | [
{
"ade": "asterixis",
"drug": "CBZ"
},
{
"ade": "asterixis",
"drug": "carbamazepine"
}
] |
Cardiomyopathy after widely separated courses of adriamycin exacerbated by actinomycin-D and mithramycin. | [
{
"ade": "Cardiomyopathy",
"drug": "adriamycin"
},
{
"ade": "Cardiomyopathy",
"drug": "mithramycin"
},
{
"ade": "Cardiomyopathy",
"drug": "actinomycin-D"
}
] |
Early recognition of hereditary motor and sensory neuropathy type 1 can avoid life-threatening vincristine neurotoxicity. | [
{
"ade": "life-threatening vincristine neurotoxicity",
"drug": "vincristine"
}
] |
Serotonin syndrome caused by selective serotonin reuptake-inhibitors-metoclopramide interaction. | [
{
"ade": "Serotonin syndrome",
"drug": "metoclopramide"
}
] |
Although this combination agent has been associated with a hypersensitivity syndrome involving cutaneous skin eruptions, pediatric cases of TMP-SMX-induced hepatotoxicity are rare. | [
{
"ade": "cutaneous skin eruptions",
"drug": "TMP-SMX"
},
{
"ade": "hypersensitivity syndrome",
"drug": "TMP-SMX"
},
{
"ade": "hepatotoxicity",
"drug": "TMP-SMX"
}
] |
Complications associated with primary and secondary perforation of the bladder following immediate instillations of epirubicin after transurethral resection of superficial urothelial tumours. | [
{
"ade": "primary and secondary perforation of the bladder",
"drug": "epirubicin"
}
] |
After having received gemcitabine on day 1 of the second course, the patient developed dry cough, subfebrile temperatures and dyspnea within 48 h. | [
{
"ade": "dyspnea",
"drug": "gemcitabine"
},
{
"ade": "dry cough",
"drug": "gemcitabine"
},
{
"ade": "subfebrile temperatures",
"drug": "gemcitabine"
}
] |
Nonoliguric acute renal failure after captopril therapy. | [
{
"ade": "Nonoliguric acute renal failure",
"drug": "captopril"
}
] |
RTA is one type of nephrotoxicity induced by FK506, and it is reversible in mild cases when appropriately treated. | [
{
"ade": "RTA",
"drug": "FK506"
},
{
"ade": "nephrotoxicity",
"drug": "FK506"
}
] |
Based on our findings, it is thus concluded that cisplatin may cause C. difficile colitis. | [
{
"ade": "C. difficile colitis",
"drug": "cisplatin"
}
] |
With the first cyclosporine dose, the patient complained of leg pain that was most severe during the cyclosporine infusion. | [
{
"ade": "leg pain",
"drug": "cyclosporine"
}
] |
Exacerbation of anthracycline-induced early chronic cardiomyopathy with ATRA: role of B-type natriuretic peptide as an indicator of cardiac dysfunction. | [
{
"ade": "early chronic cardiomyopathy",
"drug": "anthracycline"
}
] |
Therefore, clinicians should pay close attention to possible onset of RD in patients with multiple risk factors for TD, even when SDA therapy is used. | [
{
"ade": "RD",
"drug": "SDA"
}
] |
Isoniazid associated, painful, bilateral gynaecomastia. | [
{
"ade": "bilateral gynaecomastia",
"drug": "Isoniazid"
}
] |
Ciprofloxacin-induced psychosis. | [
{
"ade": "psychosis",
"drug": "Ciprofloxacin"
}
] |
Two of these patients, who also received the anti-emetic prochlorperazine, lost consciousness for 48-72 h and then fully recovered. | [
{
"ade": "lost consciousness",
"drug": "prochlorperazine"
}
] |
Disulfiram-like reactions with newer cephalosporins: cefmenoxime. | [
{
"ade": "Disulfiram-like reactions",
"drug": "cefmenoxime"
}
] |
Multiple syncopal episodes started to occur during thalidomide treatment, and a Holter electrocardiogram showed multiple abnormalities, with an episode of sustained ventricular tachycardia. | [
{
"ade": "sustained ventricular tachycardia",
"drug": "thalidomide"
},
{
"ade": "Multiple syncopal episodes",
"drug": "thalidomide"
}
] |
A 17-year-old female patient who had been taking oral minocycline (50 mg twice daily) for 3 weeks for acne developed an eruption that progressed to an exfoliative dermatitis. | [
{
"ade": "exfoliative dermatitis",
"drug": "minocycline"
},
{
"ade": "eruption",
"drug": "minocycline"
}
] |
As these cases revealed, close monitoring of blood chemistry is mandatory after starting spironolactone, and patients should be advised to stop spironolactone immediately if diarrhoea develops. | [
{
"ade": "diarrhoea",
"drug": "spironolactone"
}
] |
In the first patient, two episodes of ventricular tachycardia requiring cardioversion occurred in close temporal sequence with administering bretylium. | [
{
"ade": "ventricular tachycardia",
"drug": "bretylium"
}
] |
Captopril-induced pulmonary infiltrates with eosinophilia in an infant with congenital heart disease. | [
{
"ade": "pulmonary infiltrates with eosinophilia",
"drug": "Captopril"
}
] |
Sodium valproate and carbamazepine, antiepileptic drugs that are associated with a relatively low rate of adverse cutaneous reactions, should be added to the growing list of drugs that produce psoriasiform eruptions. | [
{
"ade": "psoriasiform eruptions",
"drug": "carbamazepine"
},
{
"ade": "psoriasiform eruptions",
"drug": "Sodium valproate"
}
] |
We report a case of seizure associated with L-asparaginase therapy but no evidence of hemorrhagic or thrombotic cerebrovascular events. | [
{
"ade": "seizure",
"drug": "L-asparaginase"
}
] |
Case 2, a 29-year-old woman, developed bilateral optic neuritis combined with numbness of the lower extremities as well as bowel and bladder dysfunction after a 22-month use of recombinant interferon alpha-2b for chronic myelogenous leukemia. | [
{
"ade": "bilateral optic neuritis",
"drug": "recombinant interferon alpha-2b"
},
{
"ade": "bowel and bladder dysfunction",
"drug": "recombinant interferon alpha-2b"
},
{
"ade": "numbness of the lower extremities",
"drug": "recombinant interferon alpha-2b"
}
] |
Two patients treated with 5-fluorouracil (5-FU) for disseminated adenocarcinoma of the colon developed cerebellar dysfunction typical of 5-FU neurotoxicity. | [
{
"ade": "neurotoxicity",
"drug": "5-FU"
},
{
"ade": "cerebellar dysfunction",
"drug": "5-FU"
},
{
"ade": "neurotoxicity",
"drug": "5-fluorouracil"
},
{
"ade": "cerebellar dysfunction",
"drug": "5-fluorouracil"
}
] |
Masculinization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment. | [
{
"ade": "Masculinization of a female fetus",
"drug": "norethisterone"
},
{
"ade": "clitoral hypertrophy",
"drug": "norethisterone"
}
] |
A typical case of dextran-40 associated acute renal failure is presented. | [
{
"ade": "acute renal failure",
"drug": "dextran-40"
}
] |
An unusual case of Ecstasy poisoning. | [
{
"ade": "Ecstasy poisoning",
"drug": "Ecstasy"
}
] |
Persistent light reactivity from systemic quinine. | [
{
"ade": "Persistent light reactivity",
"drug": "quinine"
}
] |
A case of allopurinol hypersensitivity, possibly the first in a black African, is reported. | [
{
"ade": "hypersensitivity",
"drug": "allopurinol"
}
] |
RESULTS: A male and a female patient with spasticity treated with intrathecal baclofen were recognized to have sexual dysfunction side effects from treatment. | [
{
"ade": "sexual dysfunction",
"drug": "baclofen"
}
] |
AIM: Report of a case of a woman patient who developed celiac disease after pegylated interferon alpha-2a and ribavirin use for chronic hepatitis C. | [
{
"ade": "celiac disease",
"drug": "pegylated interferon alpha-2a"
},
{
"ade": "celiac disease",
"drug": "ribavirin"
}
] |
OBJECTIVE: To report the occurrence of acute cytolytic hepatitis in a patient exposed to pulse itraconazole therapy for 24 weeks and provide a concise review of the literature on cases of itraconazole-induced hepatitis. | [
{
"ade": "hepatitis",
"drug": "itraconazole"
},
{
"ade": "acute cytolytic hepatitis",
"drug": "itraconazole"
}
] |
We describe a heroin abuser in whom clinical and laboratory manifestations of acute hepatitis B and C appeared a few days after the insertion of a subcutaneous naltrexone implant. | [
{
"ade": "acute hepatitis B and C",
"drug": "naltrexone"
}
] |
CONCLUSIONS: Patients receiving intravitreal injections of bevacizumab should be evaluated for potential systemic risk factors such as carotid insufficiency, coagulopathy and poorly controlled diabetes mellitus. | [
{
"ade": "carotid insufficiency",
"drug": "bevacizumab"
},
{
"ade": "coagulopathy",
"drug": "bevacizumab"
},
{
"ade": "poorly controlled diabetes mellitus",
"drug": "bevacizumab"
}
] |
Cardiorespiratory toxicity due to miconazole. | [
{
"ade": "Cardiorespiratory toxicity",
"drug": "miconazole"
}
] |
His impaired memory was found to be due to the atenolol he was on and he made a complete recovery on withdrawing the beta-blocker. | [
{
"ade": "impaired memory",
"drug": "atenolol"
}
] |
There is documentation of ocular toxicity with ethambutol when administered at dosages generally pronounced as being safe. | [
{
"ade": "ocular toxicity",
"drug": "ethambutol"
}
] |
Acute sensorineural hearing loss following intravenous ketoralac administration. | [
{
"ade": "Acute sensorineural hearing loss",
"drug": "ketoralac"
}
] |
CONCLUSIONS: Clinicians should be aware of this adverse reaction when facing similar complex neurologic symptoms in patients who are receiving the antibiotic treatment described here, especially vancomycin. | [
{
"ade": "neurologic symptoms",
"drug": "vancomycin"
}
] |
A patient with monocular open-angle glaucoma had trichiasis, a condition associated with the use of a prostaglandin analog. | [
{
"ade": "trichiasis",
"drug": "prostaglandin"
}
] |
Fulminant hepatitis with severe lactate acidosis in HIV-infected patients on didanosine therapy. | [
{
"ade": "Fulminant hepatitis",
"drug": "didanosine"
},
{
"ade": "severe lactate acidosis",
"drug": "didanosine"
}
] |
Findings on discontinuation and rechallenge supported the assumption that the hair loss was a side effect of the paroxetine. | [
{
"ade": "hair loss",
"drug": "paroxetine"
}
] |
RESULTS: A 34-year-old man acquired visual field defects and severe vision loss in both eyes after intravitreal injection of triamcinolone for diabetic macular edema. | [
{
"ade": "visual field defects",
"drug": "triamcinolone"
},
{
"ade": "severe vision loss",
"drug": "triamcinolone"
}
] |
INTERVENTIONS AND RESULTS: Cardiac complications were observed in five pediatric patients who received between 4.6 and 40.8 mg/kg/d of amphotericin B. | [
{
"ade": "Cardiac complications",
"drug": "amphotericin B"
}
] |
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