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39,711,963
Direct comparison of an ultrasensitive real-time PCR assay with droplet digital PCR for the detection of PIK3CA hotspot mutations in primary tumors, plasma cell-free DNA and paired CTC-derived gDNAs.
Frontiers in oncology
Front Oncol
14
null
10.3389/fonc.2024.1435559
eng
2,024
null
null
2,024
12
6
[INTRODUCTION] Detection of PIK3CA mutations in primary tumors and liquid biopsy samples is of increasing importance for treatment decisions and therapy resistance in many types of cancer. The aim of the present study was to directly compare the efficacy of a relatively inexpensive ultrasensitive real-time PCR with the...
DNA melting curve analysis; PIK3CA mutations; breast cancer; circulating tumor cells; droplet digital PCR; liquid biopsy; plasma cell-free DNA; ultrasensitive molecular assay
1.075
156
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
39,711,881
Recurrent abdominal pain in children in Wuhu, China was not associated with Helicobacter pylori infection, but associated with 1 h/day physical activity and academic stress.
Frontiers in pediatrics
Front Pediatr
12
null
10.3389/fped.2024.1481125
eng
2,024
null
null
2,024
12
6
[BACKGROUND] Recurrent abdominal pain (RAP) is one of the most common gastrointestinal disorders in children. The aim of this study was to investigate the relationship between RAP and Helicobacter pylori infection in children in Wuhu, China as well as the risk factors for Helicobacter pylori infection in this region. [...
Helicobacter pylori infection; academic stress; children; physical activity; recurrent abdominal pain
0.738
83
Pediatrics, Perinatology and Child Health
Medicine
2,024
39,711,850
Husband's Contributions to Stimulate Wife's Confidence Experiencing Role Transition: Cross-Sectional Study.
SAGE open nursing
SAGE Open Nurs
10
null
10.1177/23779608241304716
eng
2,024
null
null
2,024
12
20
[INTRODUCTION] Pregnancy can cause various physical and physiological changes. It affects confidence, resulting in depression and disturbing health not only for a mother but also for her fetus. These will also determine the ability of the mother to take care of her baby after delivery. [OBJECTIVES] To analyze the husba...
husband; primigravida pregnancy; role transition; self-confidence; wife
0.752
24
Nursing
Nursing
2,024
39,711,454
Assessment of Ketamine's Influence on In Vitro Angiogenesis.
Anesthesia progress
Anesth Prog
71
4
10.2344/23-0011
eng
2,024
12
4
2,024
12
4
[OBJECTIVE] Angiogenesis is associated with angiogenic therapy and wound healing processes. It is important for anesthesiologists to understand the effects of perioperative and long-term use of anesthetics on angiogenesis. This study aimed to determine the effects of ketamine on in vitro angiogenesis: the proliferation...
Angiogenesis; Cell Proliferation; Human umbilical vein endothelial cells; Ketamine; Migration
null
null
null
null
null
39,711,430
The efficacy and safety of anlotinib plus PD-1 inhibitor in locally advanced/metastatic esophageal squamous cell carcinoma (ESCC) patients who progressed on prior immune checkpoint inhibitors (ICIs): a retrospective real-world study (NCT 04984096).
Annals of medicine
Ann Med
57
1
10.1080/07853890.2024.2443811
eng
2,025
12
null
2,024
12
23
[BACKGROUND] Several studies have shown that combining immune checkpoint inhibitors (ICIs) with antiangiogenic tyrosine kinase inhibitors is effective for solid tumors, including esophageal squamous cell carcinoma (ESCC). However, most of these studies were focused on immunotherapy-naive patients. This retrospective re...
Anlotinib; PD-1 inhibitor; combination therapeutic regimen; esophageal squamous cell carcinoma; progressed on prior ICI
1.204
133
Medicine
Medicine
2,024
39,711,368
The expression of Siglec-10 on naive B cells is involved in the pathology of systemic lupus erythematosus.
Clinical and experimental rheumatology
Clin Exp Rheumatol
43
3
10.55563/clinexprheumatol/hlnpiz
eng
2,025
3
null
2,024
12
21
[OBJECTIVES] Previous studies have reported the expansion of CD19+Siglec-10+ B cells in systemic lupus erythematosus (SLE) patients. However, the composition of this cell population, phenotype and characteristics are still unknown. [METHODS] We examined this memory B-cell subset's composition and phenotype and determin...
null
1.004
112
Immunology; Immunology and Allergy; Rheumatology
Immunology and Microbiology; Medicine
2,024
39,711,282
Image use in aphasia rehabilitation: Practices of speech-language pathologists in South Africa and international contexts.
International journal of speech-language pathology
Int J Speech Lang Pathol
null
null
10.1080/17549507.2024.2434229
eng
2,024
12
23
2,024
12
23
[PURPOSE] The study aimed to explore speech-language pathologists' practices regarding image selection and use in the treatment of people living with aphasia. Images are widely utilised with people living with aphasia, however, supporting their communication optimally remains challenging. [METHOD] Ninety-two speech-lan...
images; people with aphasia; practices; speech-language pathologist; survey; visuographic supports
0.614
58
Linguistics and Language; LPN and LVN; Otorhinolaryngology; Research and Theory; Speech and Hearing
Health Professions; Medicine; Nursing; Social Sciences
2,024
39,711,082
The IMAP and MICAP Flaps for Autologous Breast Reconstruction: An Anatomic, Clinical, and Outcome Study.
Aesthetic surgery journal
Aesthet Surg J
45
4
10.1093/asj/sjae249
eng
2,025
3
17
null
null
null
[BACKGROUND] Local flaps for breast reconstruction are becoming recognized as a viable alternative to remote flaps. [OBJECTIVES] The purpose of this article was to describe the anatomy and clinical outcomes of internal mammary artery perforators and lateral intercostal artery perforator flaps for breast reconstruction....
null
1.254
86
Medicine; Surgery
Medicine
2,024
39,710,959
Modifiable Risk Factors for Breast Cancer: Insights From Systematic Reviews.
Public health nursing (Boston, Mass.)
Public Health Nurs
42
2
10.1111/phn.13504
eng
2,025
null
null
2,024
12
22
[OBJECTIVE] To conduct a comprehensive review of reversible factors associated with breast cancer, with the aim of offering insights for the creation of early intervention strategies for breast cancer prevention. [METHODS] The PubMed, EMBASE, and Scopus databases were systematically searched to collect systematic revie...
breast cancer; lifestyle; overview of systematic reviews; risk factors
0.723
63
Nursing; Public Health, Environmental and Occupational Health
Medicine; Nursing
2,024
39,710,660
Survey on the current practice of research ethics committees in the Czech academic environment: a mixed-methods study.
BMC medical ethics
BMC Med Ethics
25
1
10.1186/s12910-024-01157-2
eng
2,024
12
23
2,024
12
23
[BACKGROUND] The primary objective of this study was to conduct a comprehensive questionnaire survey on the practices of research ethics committees reviewing academic research projects in Czechia. The study aims to provide an unbiased and objective assessment of the current practices of research ethics committees, name...
academic research institutions; human subject research; international ethics standards; research ethics; research ethics committees; research ethics governance
1.082
66
Health Policy; Health; Issues, Ethics and Legal Aspects
Medicine; Nursing; Social Sciences
2,024
39,710,276
The interplay of plant-based antioxidants, inflammation, and clinical outcomes in asthma: A systematic review.
Respiratory medicine
Respir Med
236
null
10.1016/j.rmed.2024.107918
eng
2,025
1
null
2,024
12
20
[BACKGROUND] Asthma is a chronic inflammatory disease and a leading cause of disability, posing a huge economic and social burden. Plant-based antioxidants have the potential to block proinflammatory pathways and protect against oxidative damage, which could improve asthma management. [OBJECTIVE] This review examines t...
Antioxidants; Asthma; Oxidative stress; Plants
1.063
145
Pulmonary and Respiratory Medicine
Medicine
2,024
39,710,155
Lateral Opening Distal Femoral Osteotomy With Concomitant Medial Patellofemoral Ligament Reconstruction Is Efficacious in Addressing Patellar Instability.
Arthroscopy : the journal of arthroscopic related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association
Arthroscopy
41
8
10.1016/j.arthro.2024.12.016
eng
2,025
8
null
2,024
12
20
[PURPOSE] To describe the clinical and radiographic outcomes of patients undergoing a lateral opening distal femur osteotomy (DFO) to address valgus alignment and restore patellar stability. [METHODS] A retrospective review of patients who underwent lateral opening DFO for recurrent patellar instability in the setting ...
null
null
null
null
null
null
39,709,888
Exploring nurse educators' experiences and perceptions debriefing virtual simulations related to sexual orientation and gender identity: A qualitative study.
Nurse education today
Nurse Educ Today
146
null
10.1016/j.nedt.2024.106550
eng
2,025
3
null
2,024
12
18
[BACKGROUND] Sexual orientation and gender identity (SOGI) impact health, yet healthcare providers often lack the necessary education to address the unique needs of the 2SLGBTQIA+ community. The SOGI Nursing Toolkit was developed to enhance cultural humility among healthcare providers using virtual simulation experienc...
2SLGBTQ; Debrief; Nursing education; Virtual simulation
1.483
109
Education; Nursing
Nursing; Social Sciences
2,024
39,709,476
Targeted long-read sequencing to quantify methylation of the C9orf72 repeat expansion.
Molecular neurodegeneration
Mol Neurodegener
19
1
10.1186/s13024-024-00790-0
eng
2,024
12
21
2,024
12
21
[BACKGROUND] The gene C9orf72 harbors a non-coding hexanucleotide repeat expansion known to cause amyotrophic lateral sclerosis and frontotemporal dementia. While previous studies have estimated the length of this repeat expansion in multiple tissues, technological limitations have impeded researchers from exploring ad...
Amyotrophic lateral sclerosis; C9orf72; Frontotemporal dementia; Long-read sequencing; Methylation; Repeat expansions
5.488
126
Cellular and Molecular Neuroscience; Molecular Biology; Neurology
Biochemistry, Genetics and Molecular Biology; Medicine; Neuroscience
2,024
39,709,455
The evaluation of awareness, attitude, and performance of the residents of Bandar Abbas in relation to preventive behaviors and methods for controlling dengue fever.
BMC research notes
BMC Res Notes
17
1
10.1186/s13104-024-07046-6
eng
2,024
12
21
2,024
12
21
[OBJECTIVE] Dengue fever is a rapidly spreading viral disease transmitted by mosquitoes, and it is becoming a global concern. This study aimed to assess the awareness, attitude, and performance of the people in Hormozgan province in carrying out preventive behaviors and dengue fever control methods. [METHOD] This descr...
Attitude; Awareness; Bandar Abbas; Dengue Fever; Iran; Performance
0.435
101
Biochemistry, Genetics and Molecular Biology; Medicine
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
39,709,427
Complications and patient-reported outcomes after radiotherapy in breast cancer patients undergoing implant-based breast reconstruction: a retrospective study from a large Chinese breast disease center.
World journal of surgical oncology
World J Surg Oncol
22
1
10.1186/s12957-024-03618-9
eng
2,024
12
21
2,024
12
21
[BACKGROUND] Postmastectomy radiation therapy (PMRT) can influence the outcome of implant-based breast reconstruction (IBBR). This study aims to investigate the complications and patient-reported outcomes (PROs) following PMRT between direct-to-implant (DTI) and tissue expander-to-implant (TEI) reconstruction. [METHODS...
Breast cancer; Complication; Implant-based breast reconstruction; Patient-reported outcome; Postmastectomy radiation therapy
0.782
82
Surgery; Oncology
Medicine
2,024
39,709,366
SYNTAX I score is associated with genetically confirmed familial hypercholesterolemia in chinese patients with coronary heart disease.
BMC cardiovascular disorders
BMC Cardiovasc Disord
24
1
10.1186/s12872-024-04428-3
eng
2,024
12
21
2,024
12
21
[BACKGROUND] Familial hypercholesterolemia (FH) is a genetically inherited disorder caused by monogenic mutations or polygenic deleterious variants. Patients with FH innate with significantly elevated risks for coronary heart disease (CHD). FH prevalence based on genetic testing in Chinese CHD patients is missing. Whet...
Familial hypercholesterolemia; Monogenic; Polygenic; Prevalence; SYNTAX I score
0.708
76
Cardiology and Cardiovascular Medicine
Medicine
2,024
39,709,110
Gender differences in the association between insulin resistance assessed by estimated glucose disposal rate and the risk of all-cause and cardiovascular deaths in adults without diabetes.
Diabetes research and clinical practice
Diabetes Res Clin Pract
219
null
10.1016/j.diabres.2024.111966
eng
2,025
1
null
2,024
12
19
[AIM] We intended to examine the relationship between estimated glucose disposal rate (eGDR) and risks of all-cause and cardiovascular deaths in non-diabetic adults. [METHODS] 38,175 participants from the National Health and Nutrition Examination Survey (1999-2018) were included, and deaths were identified through the ...
Death; Gender; Non-diabetic; Risk; eGDR
1.537
146
Endocrinology; Endocrinology, Diabetes and Metabolism; Internal Medicine; Medicine
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
39,709,075
Indicator-based tuberculosis infection control assessments with knowledge, attitudes, and practices evaluations among health facilities in China, 2017 to 2019.
American journal of infection control
Am J Infect Control
53
4
10.1016/j.ajic.2024.12.013
eng
2,025
4
null
2,024
12
19
[BACKGROUND] Tuberculosis Building and Strengthening Infection Control Strategies (TB BASICS) aimed to achieve improvements in TB infection prevention and control (IPC) through structured training and mentorship. [METHODS] TB BASICS was implemented in 6 Chinese provinces from 2017 to 2019. Standardized, facility-based ...
China; Health care workers; Infection prevention; KAP
0.911
133
Health Policy; Epidemiology; Infectious Diseases; Public Health, Environmental and Occupational Health
Medicine
2,024
39,708,432
Neonatal Seizures and Associated Neurobehavioral Profiles in Preschool Age Children.
Pediatric neurology
Pediatr Neurol
163
null
10.1016/j.pediatrneurol.2024.11.008
eng
2,025
2
null
2,024
11
28
[BACKGROUND] Neonatal seizures are common with acute brain injury. Up to 25% of survivors develop postneonatal epilepsy. We hypothesized postneonatal epilepsy diagnosed by age 24 months would increase risk for early markers of neurobehavioral disorders than acute provoked neonatal seizures alone. [METHODS] Neonates wit...
Adaptive functioning; Behavior; Development; Epilepsy; Neonatal seizure; Neurobehavioral profiles; Social skills
0.825
111
Pediatrics, Perinatology and Child Health; Neurology; Neurology; Developmental Neuroscience
Medicine; Neuroscience
2,024
39,708,411
Causative diseases of bloody sputum and hemoptysis in respiratory clinics in Japan.
Respiratory investigation
Respir Investig
63
1
10.1016/j.resinv.2024.12.006
eng
2,025
1
null
2,024
12
20
[BACKGROUND] No previous studies have compared respiratory clinics and respiratory specialized facilities regarding causative diseases for bloody sputum and hemoptysis in Japan. [METHODS] We retrospectively compared causative diseases for bloody sputum and hemoptysis between 3 respiratory clinics (clinic group) and 7 d...
Bloody sputum; Bronchiectasis; Chronic obstructive pulmonary disease; Hemoptysis; Lung cancer
0.584
43
Pulmonary and Respiratory Medicine
Medicine
2,024
39,708,235
Assessing the causality between pulmonary arterial hypertension and cancer: insights from Mendelian randomization.
Discover oncology
Discov Oncol
15
1
10.1007/s12672-024-01727-1
eng
2,024
12
21
2,024
12
21
[BACKGROUND] Previous clinical studies have suggested an increased risk of tumor development in patients with pulmonary arterial hypertension (PAH). However, it remains unclear whether there is a causal relationship between PAH and tumor occurrence. This study investigates the causal link between PAH and cancer from a ...
Cancer; GWAS; Mendelian randomization; Pulmonary arterial hypertension
0.88
47
Endocrine and Autonomic Systems; Endocrinology; Endocrinology, Diabetes and Metabolism; Oncology; Cancer Research
Biochemistry, Genetics and Molecular Biology; Medicine; Neuroscience
2,024
39,758,752
Visual Performance Correlation with Corneal Aberrometric Profile and Pupil Size After Implantation of a Trifocal Hydrophobic IOL.
Clinical ophthalmology (Auckland, N.Z.)
Clin Ophthalmol
18
null
10.2147/OPTH.S500386
eng
2,024
null
null
2,024
12
31
[PURPOSE] To evaluate clinical outcomes obtained after cataract surgery involving the implantation of a trifocal hydrophobic intraocular lens (IOL) and to determine if pupil size and the corneal aberrometric profile correlate to visual acuity at different distances. [METHODS] 49 patients (98 eyes) underwent bilateral c...
aberrations; diffractive; hydrophobic; intraocular lens; pupil size; trifocal
0.936
84
Ophthalmology
Medicine
2,024
39,758,480
Factors Influencing Virtual Reality Sickness in Emergency Simulation Training.
Medical science educator
Med Sci Educ
34
6
10.1007/s40670-024-02102-z
eng
2,024
12
null
2,024
7
5
[INTRODUCTION] Virtual reality-based simulation is an educational tool that has been proven to increase participants' self-perceived, confidence, and skill. However, the use of VR is associated with virtual reality sickness (VRS). The purpose of this study is to determine related factors of VRS in an emergency setting ...
Cybersickness; Emergency Simulation; Learning Experiences; Virtual Reality
0.547
29
Education; Medicine
Medicine; Social Sciences
2,024
39,758,246
Prognostic Significance of Lymphocyte-to-Monocyte Ratio in Patients With Unresectable Biliary Tract Cancer Undergoing Systemic Chemotherapy.
Cancer diagnosis & prognosis
Cancer Diagn Progn
5
1
10.21873/cdp.10422
eng
2,025
null
null
2,025
1
3
[BACKGROUND/AIM] The incidence of biliary tract cancers (BTC), including cholangiocarcinoma and gallbladder cancer, has been increasing worldwide. Approximately 70% of BTC patients have advanced disease at diagnosis, leading to a poor survival rate. Recent clinical trials have demonstrated that the addition of immune c...
Biliary tract cancer; gemcitabine; lymphocyte-to-monocyte ratio; overall survival
null
null
null
null
null
39,757,816
Graph Machine Learning With Systematic Hyper-Parameter Selection on Hidden Networks and Mental Health Conditions in the Middle-Aged and Old.
Psychiatry investigation
Psychiatry Investig
21
12
10.30773/pi.2024.0249
eng
2,024
12
null
2,024
12
23
[OBJECTIVE] It takes significant time and energy to collect data on explicit networks. This study used graph machine learning to identify hidden networks and predict mental health conditions in the middle-aged and old. [METHODS] Data came from the Korean Longitudinal Study of Ageing (2016-2018), with 2,000 participants...
Graph machine learning; Life satisfaction; Mental health; Subjective class; Systematic hyper-parameter selection
0.703
57
Psychiatry and Mental Health; Biological Psychiatry
Medicine; Neuroscience
2,024
39,757,794
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of a Nutraceutical Supplement With Standardized Botanicals in Males With Thinning Hair.
Journal of cosmetic dermatology
J Cosmet Dermatol
24
1
10.1111/jocd.16778
eng
2,025
1
null
null
null
null
[BACKGROUND] Hair thinning in men is a prevalent issue for which treatment oftentimes consists of a multi-modal approach. Targeting key root causes of hair thinning, such as hormones, stress, and metabolism through vitamins, minerals, and botanicals, has been shown to be effective in improving hair growth and quality i...
MPHL; botanicals; hair thinning; male pattern hair loss; nutraceutical; supplement
0.764
67
Dermatology
Medicine
2,024
39,757,723
Atezolizumab plus bevacizumab in patients with unresectable or metastatic mucosal melanoma: 3-year survival update and multi-omics analysis.
Clinical and translational medicine
Clin Transl Med
15
1
10.1002/ctm2.70169
eng
2,025
1
null
null
null
null
[BACKGROUND] Atezolizumab plus bevacizumab has shown promising efficacy in advanced mucosal melanoma in the multi-centre phase II study. This report updates 3-year survival outcomes and multi-omics analysis to identify potential response biomarkers. [METHODS] Forty-three intention-to-treat (ITT) patients received intra...
VEGF inhibitor; atezolizumab; bevacizumab; immunotherapy; mucosal melanoma
3.03
24
Medicine; Molecular Medicine
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
39,757,619
KIF4A on TGF-Β1/Smad3 Pathway: A Preliminary Investigation on the Proliferation and Immune Response in In-Vitro Cultured Breast Cancer Cells.
Combinatorial chemistry & high throughput screening
Comb Chem High Throughput Screen
null
null
10.2174/0113862073356925241122055343
eng
2,024
12
26
2,024
12
26
[AIM] This study aims to explore the relevant biomarkers in breast cancer (BC). [BACKGROUND] Kinesin family member 4A (KIF4A) is a member of the Kinesin 4 subfamily of kinesin-related proteins, which has already been investigated in diverse types of tumors. [OBJECTIVE] Our current study aims to investigate the involvem...
Kinesin family member 4A; breast cancer; epithelial-tomesenchymal transition.; immune response; proliferation
null
null
null
null
null
39,757,589
'I am a Drinker': A Content, Correlational, and Factor Analytic Study of Measures of Drinker Identity Among College Students.
Substance use & misuse
Subst Use Misuse
60
5
10.1080/10826084.2024.2447429
eng
2,025
null
null
2,025
1
5
[UNLABELLED] ABSTRACT Background: Drinker identity research has proliferated over the last decade, resulting in 10 self-report questionnaire measures of this construct. However, it is unknown to what extent these measures accurately reflect the theorized multi-dimensional conceptualization of drinker identity. [OBJECTI...
Drinker identity; alcohol use; assessment; drinker self-concept; psychometrics
null
null
null
null
null
39,757,402
Middle Cerebral Artery M2 Occlusions: Impact of Segment Dominance and Benefit of Direct Aspiration for the First-Pass Effect.
Journal of neuroimaging : official journal of the American Society of Neuroimaging
J Neuroimaging
35
1
10.1111/jon.70001
eng
2,025
null
null
null
null
null
[BACKGROUND AND PURPOSE] Endovascular thrombectomy (EVT) for acute ischemic stroke (AIS) with M2 segment occlusion of the middle cerebral artery (MCA) is debatable. This study assessed the efficacy, safety, and functional outcomes of EVT in M2 occlusion patients, examining differences in outcomes based on the dominance...
M2 occlusion; distal; ischemic stroke; middle cerebral artery; thrombectomy
0.855
75
Radiology, Nuclear Medicine and Imaging; Medicine; Neurology
Medicine
2,024
39,756,681
Suboptimal Refeeding Compensates Stunting in a Mouse Model of Juvenile Malnutrition.
The Journal of nutrition
J Nutr
155
3
10.1016/j.tjnut.2025.01.002
eng
2,025
3
null
2,025
1
3
[BACKGROUND] Early postnatal life is a critical period of rapid growth in mammals, heavily reliant on adequate nutrition. Protein-energy malnutrition (PEM) during this window can lead to stunting and wasting, with lasting health consequences. [OBJECTIVES] This study developed a mouse model of juvenile PEM to assess the...
double burden of malnutrition; mice; probiotic intervention; protein energy malnutrition; stunting
1.152
306
Medicine; Nutrition and Dietetics
Medicine; Nursing
2,024
39,756,426
Schizophrenia Following Early Adolescence Prodrome: A Neurodevelopmental Subtype With Autism-like Sensorimotor and Social Cognition Deficits.
Schizophrenia bulletin
Schizophr Bull
null
null
10.1093/schbul/sbae202
eng
2,025
1
5
2,025
1
5
[BACKGROUND AND HYPOTHESIS] While age at onset in schizophrenia (SCZ) is usually defined by age at onset of psychosis, the illness actually occurs earlier, with a prodrome often starting in childhood or adolescence. We postulated that SCZ with early-adolescence prodromes (SCZ-eaP) presents with social cognition deficit...
neuroimaging; neurological soft signs; prodrome; psychosis
2.138
228
Psychiatry and Mental Health
Medicine
2,024
39,756,405
Exploring novel determinants of exercise behavior: a lagged exposure-wide approach.
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine
Ann Behav Med
59
1
10.1093/abm/kaae082
eng
2,025
1
4
null
null
null
[UNLABELLED] Many middle-aged to older adults do not engage in regular exercise at all, despite its importance for healthy aging. Extensive research grounded in behavioral and social science theories has identified numerous determinants of exercise. However, few studies used an exposure-wide approach, a data-driven exp...
exercise; lagged exposure-wide analysis; midlife; physical activity
1.491
156
Medicine; Psychiatry and Mental Health; Psychology
Medicine; Psychology
2,024
39,756,237
Melanosis of the bladder: Case study of a rare and obscure entity.
International journal of surgery case reports
Int J Surg Case Rep
126
null
10.1016/j.ijscr.2024.110802
eng
2,025
1
null
2,024
12
28
[INTRODUCTION AND IMPORTANCE] Melanosis of the bladder is a rare condition defined by the development of melanin in the bladder's urothelium and/or macrophages in the lamina propria. This condition first became known in humans in 1986, with fewer than 30 cases described in the English medical literature to date. [CASE ...
Bladder; Melanin; Melanosis; Pigmentation
0.238
31
Surgery
Medicine
2,024
39,755,896
Clinical Pharmacokinetics of Atogepant in Healthy Japanese and White Adults.
Neurology and therapy
Neurol Ther
14
1
10.1007/s40120-024-00699-2
eng
2,025
2
null
2,025
1
4
[INTRODUCTION] Atogepant is a calcitonin gene-related peptide receptor antagonist approved for the preventive treatment of migraine in adults in the USA, EU, and several other countries. The objectives of this study were to evaluate the pharmacokinetics (PK) and dose proportionality of atogepant in healthy Japanese par...
Atogepant; CGRP receptor antagonist; Japanese; Migraine; Pharmacokinetics
1.376
41
Neurology; Neurology
Medicine; Neuroscience
2,024
39,755,478
Two types of cannulated screw fixation based on Letenneur classification for the treatment of Hoffa fracture: A finite element analysis.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association
J Orthop Sci
null
null
10.1016/j.jos.2024.11.012
eng
2,025
1
3
2,025
1
3
[PURPOSE] A finite element analysis was performed to simulate the biomechanical differences between anterior-posterior (AP) direction and posterior-anterior (PA) direction placement of two cannulated screws in Hoffa fractures. [METHODS] Computed tomography images of an healthy male volunteer were used to simulate Leten...
Cannulated screw; Finite element analysis; Hoffa fracture
0.515
86
Orthopedics and Sports Medicine; Surgery
Medicine
2,024
39,755,441
Individual Rumination in Adult Cancer Care: A Concept Analysis.
Seminars in oncology nursing
Semin Oncol Nurs
41
1
10.1016/j.soncn.2024.151802
eng
2,025
2
null
2,025
1
3
[OBJECTIVE] To conceptualize rumination in adult cancer care. [METHODS] Walker and Avant's concept analysis method was used to examine rumination in adults with cancer. A systematic search was conducted across psychology, nursing, medicine, and public health disciplines in PsycINFO, PubMed, Web of Science, CINAHL, and ...
Adaptation; Adult; Cancer care; Concept Analysis; Rumination
0.651
61
Oncology
Nursing
2,024
39,755,169
A Prospective Phase II Trial of First-Line Osimertinib for Patients With EGFR Mutation-Positive NSCLC and Poor Performance Status (OPEN/TORG2040).
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
J Thorac Oncol
20
5
10.1016/j.jtho.2024.12.027
eng
2,025
5
null
2,025
1
2
[INTRODUCTION] Osimertinib is the first-line treatment for patients with NSCLC who have EGFR mutations and favorable performance status (PS). Despite the increasing clinical data on osimertinib, evidence for its use in patients with impaired PS remains limited. Therefore, a multicenter phase II trial (OPEN/TORG2040) wa...
EGFR; Osimertinib; Poor performance status; Quality of life
7.948
190
Medicine; Oncology; Pulmonary and Respiratory Medicine
Medicine
2,024
39,755,032
Two types of arteriopathies, arteriomegaly and aneurysms, frequently develop at diverse locations in vertebrobasilar dolichoectasia patients: A retrospective analysis and a meta-analysis.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
J Clin Neurosci
133
null
10.1016/j.jocn.2024.111027
eng
2,025
3
null
2,025
1
3
[BACKGROUND] Past studies have reported that vertebrobasilar dolichoectasia (VBD) patients may develop similar arteriopathies other than the vertebrobasilar system. However, the details of these VBD-related arteriopathies are still unclear. [METHODS] We retrospectively enrolled patients diagnosed with VBD at two stroke...
Aortic aneurysm; Arteriomegaly; Dolichoectasia; Intracranial aneurysm; Stroke; Visceral artery aneurysm
0.654
104
Medicine; Surgery; Neurology; Neurology; Physiology
Medicine; Neuroscience
2,024
39,754,975
Longer survival with precision medicine in late-stage cancer patients.
ESMO open
ESMO Open
10
1
10.1016/j.esmoop.2024.104089
eng
2,025
1
null
2,025
1
3
[BACKGROUND] In a per-protocol analysis of molecularly profiled patients with treatment-refractory, end-stage cancer discussed at the National Molecular Tumor Board (NMTB), we aimed to assess the overall survival (OS) outcome of targeted treatment compared with no targeted treatment. [MATERIALS AND METHODS] Patients we...
clinical trial; molecular pathway analysis; precision medicine; prognosis; tissue agnostic
3.582
70
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
39,754,762
Atrial Fibrillation-Related Bradycardia and/or Bradycardia-Related Atrial Fibrillation: When and How to Intervene.
Current vascular pharmacology
Curr Vasc Pharmacol
null
null
10.2174/0115701611336002241030072954
eng
2,025
1
1
2,025
1
1
[INTRODUCTION/OBJECTIVE] Atrial fibrillation (AF) could present with slow ventricular-response; bradycardia could facilitate the emergence of AF. The conviction that one "does not succumb" from bradycardia as an escape rhythm will emerge unless one sustains a fatal injury following syncope is in stark difference with v...
Atrial fibrillation; bradycardia; cardiac arrhythmia; heart block; sinus bradycardia; slow ventricular response
null
null
null
null
null
39,754,660
Novel Selective Cardiac Myosin-Targeted Inhibitors Alleviate Myocardial Ischaemia-Reperfusion Injury.
Cardiovascular drugs and therapy
Cardiovasc Drugs Ther
null
null
10.1007/s10557-024-07663-0
eng
2,025
1
4
2,025
1
4
[PURPOSE] Reperfusion of the ischaemic heart is essential to limit myocardial infarction. However, reperfusion can cause cardiomyocyte hypercontracture. Recently, cardiac myosin-targeted inhibitors (CMIs), such as Mavacamten (MYK-461) and Aficamten (CK-274), have been developed to treat patients with cardiac hypercontr...
Aficamten; Hypercontracture; Ischaemia; Mavacamten; Myocardial infarction; Reperfusion
1.002
83
Cardiology and Cardiovascular Medicine; Medicine; Pharmacology; Pharmacology
Medicine; Pharmacology, Toxicology and Pharmaceutics
2,024
39,754,460
Transthoracic Echocardiography for Central Venous Catheter Tip Positioning in Children: An Observational Study Using Transesophageal Echocardiography as Reference Method.
Paediatric anaesthesia
Paediatr Anaesth
35
4
10.1111/pan.15059
eng
2,025
4
null
2,025
1
4
[BACKGROUND] Children who need to have major surgery or are critically ill often require the insertion of a central venous catheter (CVC). To avoid serious complications, it is important to correctly position the CVC tip at the junction of the distal superior vena cava and the right atrium (cavoatrial junction). Transt...
anesthesia; central venous catheter tip position; infant; pediatric; ultrasound
0.658
102
Anesthesiology and Pain Medicine; Pediatrics, Perinatology and Child Health
Medicine
2,024
39,754,452
Electroacupuncture improves postoperative cognitive dysfunction by inhibiting ferroptosis via the TFR1-DMT1-FPN pathway.
Acupuncture in medicine : journal of the British Medical Acupuncture Society
Acupunct Med
43
2
10.1177/09645284241302816
eng
2,025
4
null
2,025
1
4
[OBJECTIVE] The aim of this study was to investigate the role of ferroptosis in the occurrence of postoperative cognitive dysfunction (POCD) using a mouse model and to elucidate whether electroacupuncture (EA) can improve POCD by suppressing ferroptosis via the transferrin receptor 1 (TFR1)-divalent metal transporter 1...
eletroacupuncture; ferroptosis; postoperative cognitive dysfunction; tibial fractures
0.703
57
Complementary and Alternative Medicine; Medicine; Neurology
Medicine
2,024
39,754,304
Differential Effects of the Type of Physical Exercise on Blood Pressure in Independent Older Adults.
Sports health
Sports Health
null
null
10.1177/19417381241303706
eng
2,025
1
3
2,025
1
3
[BACKGROUND] Exercise and its effect on cardiovascular diseases have been extensively studied in the elderly population. The difference in blood pressure (BP) between fit and unfit subjects can be >5 mmHg. It is not well established whether the positive effects of exercising on BP are associated with exercise type, be ...
aging; hypertension; training programs
1.366
74
Orthopedics and Sports Medicine; Physical Therapy, Sports Therapy and Rehabilitation
Health Professions; Medicine
2,024
39,754,294
Impact of number of passes and futile reperfusion in basilar artery occlusion acute ischaemic stroke.
Singapore medical journal
Singapore Med J
null
null
10.4103/singaporemedj.SMJ-2023-255
eng
2,025
1
3
2,025
1
3
[INTRODUCTION] Mechanical thrombectomy (MT) is the standard of care in anterior circulation large vessel occlusion. A vital modifiable factor is successful reperfusion. While multiple passes improve the rates of successful reperfusion, previous studies have reported progressively diminishing returns. This study aimed t...
null
0.42
74
Medicine
Medicine
2,024
39,754,165
Providing an e-cigarette starter kit for smoking cessation and reduction as adjunct to usual care to smokers with a mental health condition: findings from the ESCAPE feasibility study.
BMC psychiatry
BMC Psychiatry
25
1
10.1186/s12888-024-06387-7
eng
2,025
1
3
2,025
1
3
[BACKGROUND] Smoking rates in the UK have declined steadily over the past decades, masking considerable inequalities, as little change has been observed among people with a mental health condition. This trial sought to assess the feasibility and acceptability of supplying an electronic cigarette (e-cigarette) starter k...
E-cigarette; Harm reduction; Mental illness; Randomised controlled trial; Smoking cessation; Vaping
1.375
151
Psychiatry and Mental Health
Medicine
2,024
39,754,141
Determinants of anemia in school-going adolescents: a case study in Douala, Cameroon.
BMC public health
BMC Public Health
25
1
10.1186/s12889-024-21224-y
eng
2,025
1
4
2,025
1
4
[CONTEXT] Anemia is a medical condition resulting from a reduction in the number of red blood cells below the reference range. It is a major public health problem, particularly among adolescents, as it can have negative effects on cognitive performance, growth and reproduction. This study aims to assess the determinant...
Adolescents; Anemia; Cameroon; Douala; School environment
1.359
211
Public Health, Environmental and Occupational Health
Medicine
2,024
39,753,850
Group-Based Trajectory Modeling Identifies Distinct Patterns of Sympathetic Hyperactivity Following Traumatic Brain Injury.
Neurocritical care
Neurocrit Care
42
3
10.1007/s12028-024-02186-w
eng
2,025
6
null
2,025
1
3
[BACKGROUND] Paroxysmal sympathetic hyperactivity (PSH) occurs with high prevalence among critically ill patients with traumatic brain injury (TBI) and is associated with worse outcomes. The PSH-Assessment Measure (PSH-AM) consists of a Clinical Features Scale and a diagnosis likelihood tool (DLT) intended to quantify ...
Autonomic nervous system diseases; Brain injuries (traumatic); Cluster analysis
1.177
97
Critical Care and Intensive Care Medicine; Neurology
Medicine
2,024
39,752,999
Photodynamic antimicrobial therapy with Erythrosin B, Eosin Y, and Rose Bengal for the inhibition of fungal keratitis isolates: An in vitro study.
Journal of photochemistry and photobiology. B, Biology
J Photochem Photobiol B
263
null
10.1016/j.jphotobiol.2024.113090
eng
2,025
2
null
2,024
12
27
[INTRODUCTION] Fungal keratitis is a leading cause of corneal blindness, with current antifungal treatments having limited efficacy. One promising treatment modality is Rose Bengal (RB) photodynamic antimicrobial therapy (PDAT) that has shown mixed success against fungal keratitis. Therefore, there is a need to explore...
Antifungal; Corneal infections; Eosin Y; Erythrosin B; Filamentous fungus; Fungal keratitis; Photodynamic therapy; Rose Bengal
null
null
null
null
null
39,752,801
Influence of spatial redistribution of heterogeneities in proton beam characteristics.
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)
Phys Med
129
null
10.1016/j.ejmp.2024.104882
eng
2,025
1
null
2,025
1
2
[OBJECTIVES] The purpose of this study was to investigate the fundamental properties of spot-scanning proton beams and compare them to Monte Carlo (MC) simulations, both with and without CT calibration, using spatially diverse combinations of materials. [METHODS] A heterogeneous phantom was created by spatially distrib...
Dose uncertainty; Pencil beam scanning; Proton; Proton Uncertainties
0.771
71
Physics and Astronomy; Biophysics; Medicine; Radiology, Nuclear Medicine and Imaging
Biochemistry, Genetics and Molecular Biology; Medicine; Physics and Astronomy
2,024
39,752,371
Investigating the point prevalence, types, severity, causes and predictors of vaccines administration errors during COVID-19 pandemic in Jordan.
PloS one
PLoS One
20
1
10.1371/journal.pone.0312050
eng
2,025
null
null
2,025
1
3
[BACKGROUND] There is a paucity of research regarding COVID-19 vaccines administration errors (VAEs) during the COVID-19 pandemic. This study aimed to investigate the prevalence, types, severity, causes and predictors of VAEs in Jordan during the recent pandemic. [METHOD] This was a 3-day (Sunday, Tuesday and Thursday ...
null
0.803
467
Multidisciplinary
Multidisciplinary
2,024
39,752,215
Sexual Fluidity and Suicidal Thoughts and Behaviors in Early and Middle Adulthood: Evidence From the National Longitudinal Study of Adolescent to Adult Health.
Archives of suicide research : official journal of the International Academy for Suicide Research
Arch Suicide Res
null
null
10.1080/13811118.2024.2445244
eng
2,025
1
3
2,025
1
3
[OBJECTIVE] The present study seeks to explore the relationship between sexual fluidity and suicidal thoughts (STs) and behaviors (STBs) among adults in early and middle adulthood. [METHODS] This study utilized data from Waves IV and V of the National Longitudinal Study of Adolescent to Adult Health (ADD Health). Parti...
ADD Health; sexual fluidity; suicidal behaviors; suicidal thoughts
null
null
null
null
null
39,751,949
Local infiltration anesthesia with high dose ropivacaine and dexmedetomidine in major knee surgery is safe.
Archives of orthopaedic and trauma surgery
Arch Orthop Trauma Surg
145
1
10.1007/s00402-024-05719-2
eng
2,025
1
3
2,025
1
3
[BACKGROUND] The role of local infiltration anesthesia (LIA) in knee surgery is significant. LIA can be more potent than a nerve block, but without the downsides. A wide range of agents are used for LIA, including some off-label medications such as dexmedetomidine and ropivacaine. Dexmedetomidine has recently received ...
Adverse reaction; Arthroplasty; Arthroscopy; Dexmedetomidine; Local infiltration anesthesia; Ropivacaine
1.05
98
Medicine; Orthopedics and Sports Medicine; Surgery
Medicine
2,024
39,751,814
The economic burden of diabetes in spinal fusion surgery: a systematic review and meta-analysis.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Eur Spine J
34
3
10.1007/s00586-024-08631-w
eng
2,025
3
null
2,025
1
3
[PURPOSE] This study aimed at comparing the costs of spinal fusion surgery between patients with and without diabetes. [METHODS] Following PRISMA guidelines, a systematic search of four databases was conducted. A meta-analysis was performed on comparative studies examining diabetic versus non-diabetic adults undergoing...
Cost analysis; Diabetes; Hospital costs; Resource utilization; Spinal fusion
1.076
173
Orthopedics and Sports Medicine; Surgery
Medicine
2,024
39,751,769
Patient Characteristics, Diagnoses, and Management in a Combined Uveitis-Rheumatology Clinic.
Ophthalmology and therapy
Ophthalmol Ther
14
2
10.1007/s40123-024-01090-y
eng
2,025
2
null
2,025
1
3
[INTRODUCTION] Combined uveitis-rheumatology clinics (combined clinics) are a relatively recent clinical care model. Here we report the demographics, ocular and systemic disease characteristics, and medications utilized in patients seen in a combined clinic at a tertiary care hospital in the USA. [METHODS] Medical reco...
Autoimmune disease; Immunomodulatory therapy; Ocular cicatricial pemphigoid; Ocular inflammation; Scleritis; Uveitis
1.187
42
Ophthalmology
Medicine
2,024
39,751,662
Cytokine profile of bronchoalveolar lavage in patients with and without checkpoint inhibitor pneumonitis.
Cancer immunology, immunotherapy : CII
Cancer Immunol Immunother
74
2
10.1007/s00262-024-03902-3
eng
2,025
1
3
2,025
1
3
[BACKGROUND] Checkpoint inhibitor pneumonitis (CIP) that develops following immune checkpoint inhibitor (ICI) treatment can be difficult to distinguish from other common etiologies of lung inflammation in cancer patients. Here, we evaluate the bronchoalveolar lavage fluid (BAL) for potential biomarkers specific to CIP....
Immune checkpoint inhibitor pneumonitis; cancer; immunotherapy
1.716
142
Cancer Research; Immunology; Immunology and Allergy; Medicine; Oncology
Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Medicine
2,024
39,750,011
Comparison of marginal fit between milled and three-dimensional printed polymethylmethacrylate prostheses for single crowns, anterior bridges, and pier abutment bridges: An in vitro study.
Journal of Indian Prosthodontic Society
J Indian Prosthodont Soc
25
1
10.4103/jips.jips_40_24
eng
2,025
1
1
2,025
1
3
[AIM] The purpose of this in vitro study was to compare the marginal fit of various three-dimensional (3D) printed and milled polymethylmethacrylate (PMMA) dental prostheses. [SETTINGS AND DESIGN] The study was conducted in an in vitro study setting. [MATERIALS AND METHODS] With a sample size of 45 for each fabrication...
null
0.41
35
Dentistry; Oral Surgery
Dentistry
2,024
39,749,969
Evaluation of the immunogenicity of a DNA vaccine for Leishmania major based on the Leishmania-activated C kinase antigen using calcium phosphate and chitosan adjuvants.
Transactions of the Royal Society of Tropical Medicine and Hygiene
Trans R Soc Trop Med Hyg
119
3
10.1093/trstmh/trae126
eng
2,025
3
7
null
null
null
[BACKGROUND] Leishmaniasis represents a significant parasitic disease with global health implications, and the development of an affordable and effective vaccine could provide a valuable solution. This study aimed to evaluate the immunogenicity of a DNA vaccine targeting Leishmania major specifically based on the Leish...
DNA vaccine; LACK; leishmaniasis; nano-adjuvants
0.644
120
Infectious Diseases; Medicine; Parasitology; Public Health, Environmental and Occupational Health
Immunology and Microbiology; Medicine
2,024
39,749,915
Issuing of albumin solutions to Danish public hospitals-A nationwide, retrospective, observational study based on pharmacy data from 2022.
Acta anaesthesiologica Scandinavica
Acta Anaesthesiol Scand
69
2
10.1111/aas.14570
eng
2,025
2
null
null
null
null
[BACKGROUND] Intravenous albumin is used for resuscitation and substitution but is not supported by high-certainty evidence. As clinical practice likely varies, we aimed to describe the issuing of albumin solutions across Danish public hospitals. [METHODS] We assessed issuing of intravenous albumin solutions (5% and 20...
albumin; fluid therapy; hospital fluid management; resuscitation fluids
0.749
126
Anesthesiology and Pain Medicine; Medicine
Medicine
2,024
39,749,821
Eosinopenia in bronchiectasis: A novel biomarker for morbidity and mortality.
Chronic respiratory disease
Chron Respir Dis
22
null
10.1177/14799731241296847
eng
2,025
null
null
null
null
null
[BACKGROUND] The paradigm of bronchiectasis is shifting away from its exclusive characterization as a neutrophilic condition. Patients with bronchiectasis and high eosinophil levels have been found to have a specific phenotype, but the clinical effect of eosinopenia remains unclear. [METHOD] A retrospective, single-cen...
Eosinophils; bronchiectasis; exacerbation
null
null
null
null
null
39,749,471
Utilising snake rescue data to understand snake-human conflict in Hooghly, West Bengal, India.
Transactions of the Royal Society of Tropical Medicine and Hygiene
Trans R Soc Trop Med Hyg
119
8
10.1093/trstmh/trae124
eng
2,025
8
8
null
null
null
[BACKGROUND] Snakebite envenoming, classified as a neglected tropical disease, poses a significant threat to life in India, where it is estimated to cause 58 000 fatalities as well as 140 000 morbidities annually. To reduce the occurrence of snakebite, we need a comprehensive understanding of human-snake conflict ecolo...
EpiCollect5; climate effects; ecology; snake rescue networks; snakebite mitigation
0.644
120
Infectious Diseases; Medicine; Parasitology; Public Health, Environmental and Occupational Health
Immunology and Microbiology; Medicine
2,024
39,749,307
Cytokine release syndrome treated with tocilizumab following ipilimumab-nivolumab combination therapy in advanced renal cell carcinoma.
IJU case reports
IJU Case Rep
8
1
10.1002/iju5.12812
eng
2,025
1
null
2,024
11
29
[INTRODUCTION] Cytokine release syndrome is a rare but potentially life-threatening complication of immune checkpoint inhibitor therapy. Its occurrence in renal cell carcinoma treated with combination therapy is less recognized and poses significant management challenges. [CASE PRESENTATION] A 50-year-old male with met...
cytokine release syndrome; immune checkpoint inhibitors; renal cell carcinoma; tocilizumab
null
null
null
null
null
39,749,098
Practical guidelines for developing digital health solutions to increase equity in dementia care in the UK.
Frontiers in digital health
Front Digit Health
6
null
10.3389/fdgth.2024.1490156
eng
2,024
null
null
2,024
12
19
[BACKGROUND] Digital Healthcare Solutions (DHS) are transforming healthcare by improving patients' experiences, safety and quality of care. However, despite all the proposed and observed advantages of DHS, a growing body of research suggests that these DHS are not equally accessible to all. This research aimed to asses...
UK; dementia; digital health solutions; equity; practical guidelines
1.07
32
Biomedical Engineering; Computer Science Applications; Health Informatics; Medicine
Computer Science; Engineering; Medicine
2,024
39,748,288
Continuous ambulatory peritoneal dialysis technique failure in adult patients treated at a tertiary hospital in central South Africa: a retrospective analytical study.
BMC nephrology
BMC Nephrol
26
1
10.1186/s12882-024-03927-x
eng
2,025
1
2
2,025
1
2
[BACKGROUND] Continuous ambulatory peritoneal dialysis (CAPD) is one of the kidney replacement therapy (KRT) modalities used in patients with kidney failure. It is the preferred modality in most resource-limited settings as it is more accessible and cost-effective. CAPD technique failure remains a challenge and is asso...
Continuous ambulatory peritoneal dialysis; Kidney replacement therapy; Patient survival; Peritonitis; Technique failure
0.805
83
Nephrology
Medicine
2,024
39,748,196
Identifying mild traumatic brain injury in the post-acute polytrauma setting: a scoping review of diagnostic approaches and screening tools.
Brain injury
Brain Inj
39
6
10.1080/02699052.2024.2443771
eng
2,025
5
12
2,025
1
2
[OBJECTIVE] Mild traumatic brain injury (mTBI) is frequently overlooked in polytrauma patients due to the overshadowing of more severe injuries, a fact that makes its identification in post-acute settings challenging since symptoms overlap with other conditions and no validated diagnostic tools exist. To address this g...
Concussion; adult brain injury; guidelines; head trauma; polytrauma; rehabilitation; screening tools
0.572
122
Developmental and Educational Psychology; Neurology; Neuroscience
Medicine; Neuroscience; Psychology
2,024
39,748,129
Oxaliplatin induces pyroptosis in hepatoma cells and enhances antitumor immunity against hepatocellular carcinoma.
British journal of cancer
Br J Cancer
132
4
10.1038/s41416-024-02908-z
eng
2,025
3
null
2,025
1
2
[BACKGROUND] Pyroptosis is closely associated with chemotherapeutic drugs and immune response. Here, we investigated whether oxaliplatin, a key drug in FOLFOX-hepatic artery infusion chemotherapy (FOLFOX-HAIC), induces pyroptosis in hepatoma cells and enhances antitumor immunity after tumor cell death. [METHODS] Hepato...
null
3.144
281
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
39,746,762
Rapid quantitative PCR on tongue swabs for pulmonary tuberculosis in adults: a prospective multicentre study.
The European respiratory journal
Eur Respir J
65
1
10.1183/13993003.01493-2024
eng
2,025
1
null
2,025
1
2
[BACKGROUND] Tuberculosis (TB) remains a major cause of infectious disease mortality globally, with significant underdiagnosis perpetuating transmission. Tongue swab analysis has emerged as a promising non-invasive method for pulmonary TB diagnosis. This study evaluates the diagnostic accuracy of the TB-EASY quantitati...
null
4.502
299
Medicine; Pulmonary and Respiratory Medicine
Medicine
2,024
39,746,411
Integrated bioinformatics and multi-omics to investigate the mechanism of Rhododendron molle Flos-induced hepatotoxicity.
Journal of ethnopharmacology
J Ethnopharmacol
341
null
10.1016/j.jep.2024.119308
eng
2,025
2
11
2,024
12
31
[ETHNOPHARMACOLOGICAL RELEVANCE] Drug-induced liver injury (DILI) is an important and common adverse drug event. Rhododendron molle Flos (RMF), as one of toxic Traditional Chinese medicines (TCMs), holds a prominent position in clinical practice for treating rheumatoid arthritis. However, the toxicity of RMF limits its...
Hepatotoxicity; Metabolomics; Network toxicology; Rhododendron molle; Transcriptomics
1.142
243
Drug Discovery; Pharmacology
Pharmacology, Toxicology and Pharmaceutics
2,024
39,745,401
Safety, efficacy, and changing trends in endoscopic ablation for dysplastic Barrett esophagus in Poland: a long-term multicenter retrospective analysis.
Polish archives of internal medicine
Pol Arch Intern Med
135
1
10.20452/pamw.16912
eng
2,025
1
30
2,025
1
2
[INTRODUCTION] Endoscopic ablation is the mainstay of treatment for dysplastic Barrett esophagus (BE), of which radiofrequency ablation (RFA) and argon plasma coagulation (APC) are the most widely available options. [OBJECTIVES] We aimed to analyze the safety and outcomes of endoscopic ablation for BE at the Polish cen...
null
0.554
48
Internal Medicine
Medicine
2,024
39,745,364
Structurally Oriented Classification of FOXA1 Alterations Identifies Prostate Cancers with Opposing Clinical Outcomes and Distinct Molecular and Immunologic Subtypes.
Clinical cancer research : an official journal of the American Association for Cancer Research
Clin Cancer Res
31
5
10.1158/1078-0432.CCR-24-3471
eng
2,025
3
3
null
null
null
[PURPOSE] Around 10% to 15% of prostate cancers harbor recurrent aberrations in the Forkhead Box A1 gene, FOXA1, whereby the alteration type and the effect on the forkhead (FKH) domain affect protein function. We developed a FOXA1 classification system to inform clinical management. [EXPERIMENTAL DESIGN] A total of 5,0...
null
4.8
392
Cancer Research; Oncology
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
39,745,278
Injury Patterns in Academy-Level Male Youth Soccer Players: A 3-Season Prospective Cohort Study.
Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine
Clin J Sport Med
35
4
10.1097/JSM.0000000000001288
eng
2,025
1
3
2,025
1
3
[OBJECTIVE] To report injury epidemiology in youth male academy-level athletes in the United States. [DESIGN] An observational study on injury occurrences and playing time over the 2019 to 2020, 2020 to 2021, and 2021 to 2022 soccer seasons. [SETTING] Data collected from a single midwestern soccer academy in the United...
United States; academy-level; injury epidemiology; male; soccer; youth
0.72
121
Orthopedics and Sports Medicine; Physical Therapy, Sports Therapy and Rehabilitation; Sports Science
Health Professions; Medicine
2,024
39,744,906
Automated Cone Beam Computed Tomography Segmentation of Multiple Impacted Teeth With or Without Association to Rare Diseases: Evaluation of Four Deep Learning-Based Methods.
Orthodontics craniofacial research
Orthod Craniofac Res
28
3
10.1111/ocr.12890
eng
2,025
6
null
2,025
1
2
[OBJECTIVE] To assess the accuracy of three commercially available and one open-source deep learning (DL) solutions for automatic tooth segmentation in cone beam computed tomography (CBCT) images of patients with multiple dental impactions. [MATERIALS AND METHODS] Twenty patients (20 CBCT scans) were selected from a re...
cone beam computed tomography; deep learning; impacted; orthodontics; surgery; tooth
null
null
null
null
null
39,744,237
Trajectories in waist circumference and waist-to-height ratio with left ventricular hypertrophy in childhood.
Frontiers in nutrition
Front Nutr
11
null
10.3389/fnut.2024.1506191
eng
2,024
null
null
2,024
12
18
[BACKGROUND AND OBJECTIVE] Previous studies have shown positive associations of waist circumference (WC) and waist-to-height ratio (WHtR) with left ventricular hypertrophy (LVH) among children and adolescents. However, most of these studies were cross-sectional or limited to only two time points. We aim to estimate the...
central obesity; childhood; left ventricular hypertrophy; waist circumference; waist-to-height ratio
1.115
94
Food Science; Nutrition and Dietetics; Endocrinology, Diabetes and Metabolism
Agricultural and Biological Sciences; Medicine; Nursing
2,024
39,744,020
Neurodevelopmental benefits of judo training in preschool children: a multinational, mixed methods follow-up study.
Frontiers in psychology
Front Psychol
15
null
10.3389/fpsyg.2024.1457515
eng
2,024
null
null
2,024
12
18
[INTRODUCTION] In our quasi-experimental study, we evaluated the neurodevelopmental impact of judo on young children (n = 182) aged 4-7 years, specifically focusing on primitive reflex integration. Participants were divided into judo and non-judo control groups, and assessments were conducted over 6 months across Hunga...
CNS; cognitive development; judo; motor skills; neurodevelopment; primitive reflexes; visual perceptual test
0.872
212
Psychology
Psychology
2,024
39,743,743
Analyzing the Utilization of Simulation Within Public Health Nursing: A Systematic Review.
Public health nursing (Boston, Mass.)
Public Health Nurs
42
2
10.1111/phn.13518
eng
2,025
null
null
2,025
1
1
[BACKGROUND] Public and community health nursing curriculum falls short in providing an assessment of student achievement through competency-based education. The aim of this evidence-based practice research was to demonstrate a lack of simulation use as a pedagogical means for the assessment of student achievement of c...
public health; public health competencies; simulation
0.723
63
Nursing; Public Health, Environmental and Occupational Health
Medicine; Nursing
2,024
39,743,668
Predicting working alliance in psychotherapy: A multi-modal machine learning approach.
Psychotherapy research : journal of the Society for Psychotherapy Research
Psychother Res
35
2
10.1080/10503307.2024.2428702
eng
2,025
2
null
2,025
1
1
[OBJECTIVE] Session-by-session tracking of the working alliance enables clinicians to detect alliance deterioration and intervene accordingly, which has shown to improve treatment outcome, and reduce dropout. Despite this, regular use of alliance self-report measures has failed to gain widespread implementation. We aim...
machine learning; multi-modal; prediction; psychotherapy; working alliance
1.574
92
Clinical Psychology
Psychology
2,024
39,743,558
Plasma phospho-tau217 as a predictive biomarker for Alzheimer's disease in a large south American cohort.
Alzheimer's research therapy
Alzheimers Res Ther
17
1
10.1186/s13195-024-01655-w
eng
2,025
1
2
2,025
1
2
[BACKGROUND] Blood-based Alzheimer's disease (AD) biomarkers have been increasingly employed for diagnostic, prognostic, and therapeutic monitoring purposes, due to accuracy in distinguishing AD pathophysiologic process. Compared to other p-tau isoforms, plasma p-tau217 exhibits stronger associations with AD hallmarks ...
APOE; P-tau217; Plasma; Plasma biomarker
null
null
null
null
null
39,743,491
The rewards and challenges of self-managing National Disability Insurance Scheme: Exploration of parental perspectives.
Australian occupational therapy journal
Aust Occup Ther J
72
1
10.1111/1440-1630.13007
eng
2,025
2
null
null
null
null
[INTRODUCTION] Under the National Disability Insurance Scheme (NDIS), participants can self-manage their funding. This management style largely deviates from previous Australian service systems. The self-management option provides NDIS participants flexibility and choice in accessing any services; however, it generates...
NDIS; National Disability Insurance Scheme; caregivers; disability; parents of children with disabilities; policy
0.65
56
Occupational Therapy
Health Professions
2,024
39,743,218
Short-Term Hormonal Changes Following Microdissection Testicular Sperm Extraction among Men with Non-Obstructive Azoospermia: Findings from a Large Longitudinal Prospective Multicentric Study.
The world journal of men's health
World J Mens Health
43
3
10.5534/wjmh.240184
eng
2,025
7
null
2,024
11
27
[PURPOSE] We aimed to investigate possible hormonal changes following microdissection testicular sperm extraction (mTESE) in men with non-obstructive azoospermia (NOA) across three referral centers. [MATERIALS AND METHODS] We prospectively analyzed data from 102 consecutive NOA men. Patients with prior hormonal therapi...
Azoospermia; Infertility, male; Surgical procedures, operative; Testosterone
1.139
34
Health Policy; Pharmacology; Public Health, Environmental and Occupational Health; Reproductive Medicine; Urology; Aging; Psychiatry and Mental Health
Biochemistry, Genetics and Molecular Biology; Medicine
2,024
39,743,007
Evaluation of current patient-based real-time quality control in clinical chemistry testing.
Clinica chimica acta; international journal of clinical chemistry
Clin Chim Acta
567
null
10.1016/j.cca.2024.120115
eng
2,025
2
1
2,024
12
30
[INTRODUCTION] To perform simulation studies on patient-based real-time quality control (PBRTQC) for aspartate aminotransferase (AST), iron (Fe), potassium (K), and thyrotropin (thyroid stimulating hormone, TSH) analytes, focusing on optimizing systematic error detection while minimizing data loss. [METHODS] Clinical l...
Data Analytics; Laboratory Information System; Laboratory Management; Patient Based Real Time Quality Control; Systematic Error
null
null
null
null
null
39,742,692
Effects of Radiotherapy Alone Versus Concomitant Radiotherapy With Temozolomide Chemotherapy on the Outcome of IDH-wildtype Glioblastoma Patients.
Clinical oncology (Royal College of Radiologists (Great Britain))
Clin Oncol (R Coll Radiol)
38
null
10.1016/j.clon.2024.103741
eng
2,025
2
null
2,024
12
19
[BACKGROUND] Isocitrate dehydrogenase [IDH]-wildtype glioblastoma is an aggressive brain cancer associated with high recurrence and poor overall survival. [AIM] Our study aims to explore the prognostic effects of radiotherapy [RT] alone versus concomitant RT with temozolomide [TMZ]. [METHODS] A multicentre retrospectiv...
Chemotherapy; Glioblastoma; IDH-wildtype; Prognosis; Radiotherapy
0.965
94
Radiology, Nuclear Medicine and Imaging; Oncology
Medicine
2,024
39,742,668
Empowering Futures: The Impact of Surgical Research Pipeline Programs on Undergraduate Career Development.
Journal of surgical education
J Surg Educ
82
2
10.1016/j.jsurg.2024.103393
eng
2,025
2
null
2,024
12
31
[PURPOSE] Surgical research pipeline programs provide a unique insight into academic surgery, offering a distinctive opportunity for aspiring future surgeons and medical professionals to identify suitable mentorship. The objective of this study was to determine the impact of an academic summer research, shadowing, and ...
mentorship; pipeline; surgical education; undergraduate students
0.83
78
Education; Surgery
Medicine; Social Sciences
2,024
39,742,383
Targeted Treatment of Metastatic Triple-Negative Breast Cancer: A Systematic Review.
The breast journal
Breast J
2024
null
10.1155/2024/9083055
eng
2,024
null
null
2,024
7
11
[INTRODUCTION] Triple-negative breast cancer (TNBC) is a subgroup of breast cancer characterized by the absence of estrogen and the human epidermal 2 receptor and also a lack of targeted therapy options. Chemotherapy has so far been the only approved treatment option, and patients with metastatic cancer have a dismal p...
null
null
null
null
null
null
39,742,359
Digital Self-Management Intervention Paths for Early Breast Cancer Patients: Results of a Pilot Study.
The breast journal
Breast J
2024
null
10.1155/2024/8036696
eng
2,024
null
null
2,024
8
13
[BACKGROUND] Despite excellent prognosis of early breast cancer, the patients face problems related to decreased quality of life and mental health. There is a need for easily available interventions targeting modifiable factors related to these problems. The aim of this study was to test the use of a new digital suppor...
null
null
null
null
null
null
39,742,064
In vitro evaluation of anti-microbial efficacy of Trigonella foenum-graecum and its constituents on oral biofilms.
Journal of Indian Society of Periodontology
J Indian Soc Periodontol
28
3
10.4103/jisp.jisp_540_23
eng
2,024
null
null
2,024
12
2
[BACKGROUND AND OBJECTIVE] The extracts obtained from the leaves and seeds of Trigonella foenum-graecum (Fenugreek) are effective against various microbial infections. The phytoconstituents of Trigonella foenum-graecum have shown promising effects as anti-diabetics, anti-helmentic, anti-microbial, antifungal, and antip...
Antimicrobial; Trigonella foenum-graecum; fenugreek; herbal; oral diseases; periodontal disease; phytoconstituents
0.367
45
Periodontics
Dentistry
2,024
39,742,035
Impact of Fatigue on Work Productivity, Activity Impairment, and Healthcare Resource Utilization in Inflammatory Bowel Disease.
Crohn's colitis 360
Crohns Colitis 360
7
1
10.1093/crocol/otae073
eng
2,025
1
null
2,024
12
21
[OBJECTIVES] Fatigue is commonly reported in patients with Crohn's disease (CD) and ulcerative colitis (UC), including patients with inactive disease. We explored the impact of fatigue on healthcare utilization (HCU) and work productivity and activity impairment (WPAI). [METHODS] Data collected between 2017 and 2022 we...
CorEvitas IBD Registry; disease activity; fatigue; inflammatory bowel disease; work productivity
null
null
null
null
null
39,741,937
Knowledge, attitude, and practice toward foodborne disease among Chinese college students: a cross-sectional survey.
Frontiers in public health
Front Public Health
12
null
10.3389/fpubh.2024.1435486
eng
2,024
null
null
2,024
12
17
[BACKGROUND] More than 200 diseases are caused by eating food contaminated and the burden of foodborne disease is considered to be high worldwide. Foodborne diseases are an important public health issue, and the knowledge, attitudes and practices among college students are crucial in preventing outbreaks. [OBJECTIVE] T...
China; attitudes; foodborne diseases; knowledge; practices; students
1.027
119
Public Health, Environmental and Occupational Health
Medicine
2,024
39,741,792
Real-World Outcomes in Pre-Existing Neovascular Age-Related Macular Degeneration Subjects Undergoing Avacincaptad Therapy for Geographic Atrophy.
Clinical ophthalmology (Auckland, N.Z.)
Clin Ophthalmol
18
null
10.2147/OPTH.S497678
eng
2,024
null
null
2,024
12
27
[PURPOSE] To evaluate real-world outcomes in subjects with pre-existing neovascular age-related macular degeneration (AMD) undergoing intravitreal avacincaptad pegol (IVA) treatment for geographic atrophy (GA). [METHODS] This study was undertaken as a retrospective, case-controlled assessment of patients undergoing IVA...
Izervay; avacincaptad pegol; complement inhibition; geographic atrophy
0.936
84
Ophthalmology
Medicine
2,024
39,741,751
Identification of Angiogenesis-Related Gene Signatures and Prediction of Potential Therapeutic Targets in Ulcerative Colitis Using Integrated Bioinformatics.
Journal of inflammation research
J Inflamm Res
17
null
10.2147/JIR.S478880
eng
2,024
null
null
2,024
12
27
[OBJECTIVE] This study aims to clarify angiogenesis mechanisms in ulcerative colitis and identify potential therapeutic targets. [METHODS] The Gene Expression Omnibus (GEO) database was used to obtain expression profiles and clinical data for UC and healthy colon tissues. Angiogenesis-related gene sets were acquired fr...
GSEA; WGCNA; bioinformatics analysis; molecular docking; ulcerative colitis
1.14
58
Immunology; Immunology and Allergy
Immunology and Microbiology; Medicine
2,024
39,741,640
Antibodies Against Phosphorylcholine in Prediction of Cardiovascular Disease Among Women: A Population-Based Prospective Cohort Study.
JACC. Advances
JACC Adv
3
11
10.1016/j.jacadv.2024.101298
eng
2,024
11
null
2,024
10
2
[BACKGROUND] Antibodies against phosphorylcholine (anti-PC) have been reported as associated with protection against atherosclerosis, cardiovascular disease (CVD), and other chronic inflammatory diseases. Underlying potential mechanisms have been demonstrated and include anti-inflammatory, clearance of dead cells, and ...
antibodies; cardiovascular disease; myocardial infarction; phosphorylcholine; stroke
null
null
null
null
null
39,741,205
The impact of gender-affirming interventions on eating disorder diagnosis risk among transgender and gender-diverse individuals.
Communications medicine
Commun Med (Lond)
4
1
10.1038/s43856-024-00704-7
eng
2,024
12
31
2,024
12
31
[BACKGROUND] The objective of this study is to evaluate the risk of being diagnosed with an eating disorder among transgender and gender-diverse (TGD) individuals, specifically examining how this risk differs following gender-affirming medical therapy (GAMT). [METHODS] The study utilizes electronic medical record (EMR)...
null
2.098
28
Assessment and Diagnosis; Epidemiology; Internal Medicine; Medicine; Public Health, Environmental and Occupational Health
Medicine; Nursing
2,024
39,741,091
Risk Factors and Treatment Strategies for Anastomotic Ulcers in Pediatric Intestinal Failure.
Journal of pediatric surgery
J Pediatr Surg
60
6
10.1016/j.jpedsurg.2024.162118
eng
2,025
6
null
2,024
12
20
[PURPOSE] Anastomotic ulcers (AUs) are a rare cause of morbidity in intestinal failure (IF). Prior studies of AUs have been small, descriptive reports. We evaluated a large cohort of IF patients to identify risk factors and describe treatment strategies for AUs. [METHODS] This was a retrospective, case-control study of...
Anastomotic ulcer; Intestinal failure; Short bowel syndrome
0.95
147
Medicine; Pediatrics, Perinatology and Child Health; Surgery
Medicine
2,024
39,741,026
Dermatophytosis caused by Nannizzia gypsea: report of 155 cases from Western Mexico.
Enfermedades infecciosas y microbiologia clinica (English ed.)
Enferm Infecc Microbiol Clin (Engl Ed)
43
4
10.1016/j.eimce.2024.12.002
eng
2,025
4
null
2,024
12
30
[BACKGROUND] Dermatophytosis caused by Nannizzia gypsea are considered rare. The clinical picture is indistinguishable from that produced by other dermatophytes, but, being this a geophilic fungus, it can cause more inflammatory disease. [METHODS] Retrospective study. Patients with positive culture for N. gypsea observ...
Dermatofitosis; Dermatophytosis; Epidemiology; Infection; Mexico; Nannizzia gypsea; Tinea
0.337
49
Infectious Diseases; Microbiology; Microbiology
Immunology and Microbiology; Medicine
2,024
39,740,939
Scoping review of social workers' professional roles in primary care.
BMJ open
BMJ Open
14
12
10.1136/bmjopen-2024-090527
eng
2,024
12
31
2,024
12
31
[OBJECTIVES] Maximising social workers' contributions to primary care requires clarity about their scope of practice in this context. This scoping review sought to clarify what is known about social work's scope of practice in primary care settings. [DESIGN] A scoping review design guided by the five-stage scoping revi...
Health Services; Primary Care; Primary Health Care
1.016
176
Medicine
Medicine
2,024
39,740,654
Invasive Intracranial Electroencephalography Monitoring in the Child with a Bleeding Disorder: Challenges and Considerations.
Pediatric neurosurgery
Pediatr Neurosurg
60
1-2
10.1159/000543194
eng
2,025
null
null
2,024
12
31
[INTRODUCTION] Hereditary bleeding disorders stem from the absence or insufficient levels of particular clotting proteins, essential for facilitating coagulation in the clotting cascade. Among the most prevalent are hemophilia A (deficiency of factor VIII), hemophilia B (deficiency of factor IX), and von Willebrand dis...
Bleeding disorder; Epilepsy; Intracranial electroencephalography; Pediatrics
0.415
81
Pediatrics, Perinatology and Child Health; Surgery; Medicine; Neurology
Medicine
2,024
39,740,289
The pectoralis major myocutaneous pedicled flap-Its past and current practice in a dedicated microsurgery service. Review of the literature, and debunking controversies.
Journal of plastic, reconstructive aesthetic surgery : JPRAS
J Plast Reconstr Aesthet Surg
101
null
10.1016/j.bjps.2024.11.047
eng
2,025
2
null
2,024
11
28
[BACKGROUND] The pectoralis major myocutaneous pedicled (PMMP) flap is still considered by many a workhorse flap in head and neck (HN) reconstruction, despite free flap surgery advancing. The authors aimed to examine this claim and associated myths and controversies by analyzing literature trends and revealing the role...
Head and neck reconstruction; Head and neck surgeon; Pectoralis major flap
null
null
null
null
null
39,740,096
Association of hemoglobin levels with metabolic traits in women with PCOS.
Acta obstetricia et gynecologica Scandinavica
Acta Obstet Gynecol Scand
104
2
10.1111/aogs.15047
eng
2,025
2
null
2,024
12
30
[INTRODUCTION] Within normal variation, higher hemoglobin (Hb) levels are associated with poorer metabolic profile in population cohorts, underlying the link between oxygen delivery and cell metabolism. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women and is commonly accompanied by met...
PCOS; cohort studies; hemoglobin; metabolism
1.274
126
Medicine; Obstetrics and Gynecology
Medicine
2,024
39,739,234
Community pharmacists' perceptions of their challenges in relation to older adults prescribed psychotropic medications: a focus-group study.
International journal of clinical pharmacy
Int J Clin Pharm
47
3
10.1007/s11096-024-01856-1
eng
2,025
6
null
2,024
12
31
[BACKGROUND] The management of psychotropic medication in older adults is a challenge for every healthcare professional, but data concerning community pharmacists are scarce in the literature. [AIM] Our objectives were i) to understand the difficulties encountered by community pharmacists in managing older adults on ps...
Aged; Community pharmacy services; Focus groups; Latrogenic disease; Psychotropic drugs
0.748
74
Pharmaceutical Science; Pharmacy; Pharmacology; Pharmacology; Toxicology
Health Professions; Medicine; Pharmacology, Toxicology and Pharmaceutics
2,024