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To assess the association of insulin-like growth factor 1 (IGF-1) with the risk of incident ischaemic stroke and outcome after ischaemic stroke.</AbstractText>A systematic review of primary studies.</AbstractText>Hospitals in Western Sweden, Italy, China and Denmark.</AbstractText>A search was carried out in eligible s... |
<b>Objective:</b> This study explored the thromboembolism risk of low-risk atrial fibrillation (AF) patients (CHA<sub>2</sub>DS<sub>2</sub>-VASc score of 0 or 1 for male and 1 or 2 for female) with different clinical characteristics to provide the basis for anticoagulation decision-making in these patients. <b>Methods:... |
In July 2015, King Faisal Hospital Family Medicine clinics (KFH-FMC) successfully implemented a paperless, fully integrated, electronic healthcare system. The aim of this study is to evaluate the impact of moving to a fully integrated electronic medical record system, with clinical decision support (CDS) systems, on th... |
Minimally invasive knee arthroplasty is rapidly gaining recognition with the aim of reducing the damage to the extensional mechanism of traditional medial parapatellar approach and achieving faster recovery of patients after surgery. The purpose of this meta-analysis was to compare the efficacy and safety of mini-subva... |
Symptoms of gastroesophageal reflux disease (GERD) are common in various chronic respiratory diseases, but little is known about GERD in the setting of chronic obstructive pulmonary disease (COPD). The aim of this study was to determine the effect of GERD symptoms on COPD exacerbations and subsequent hospitalization an... |
The potential for coordinated, multidisciplinary telehealth to help connect people with Parkinson disease (PD) in rural areas to PD specialists is crucial in optimizing care. Therefore, this study aimed to test the feasibility, safety, and signal of efficacy of a coordinated telehealth program, consisting of speech the... |
PURPOSE: To evaluate the clinical efficacy of a curved nitinol stent-graft for
repair of thoracic aortic aneurysms.
METHODS: The Matsui-Kitamura stent-graft (MKSG), composed of a self-expanding
nitinol stent and polyester fabric, was shaped to match the aortic curvature of
11 patients (6 men; mean age 72.6 years, ra... |
OBJECTIVES: This study was conducted to determine the association between radial
access, guided femoral access, and non-guided femoral access on postprocedural
bleeding and vascular complications after percutaneous coronary intervention
(PCI).
BACKGROUND: Bleeding events and major vascular complications after PCI ar... |
sinus rhythm. poor r wave progression - probable normal variant. borderline ecg. |
The famous quotation of Winston Churchill, made in his radio broadcast of 1939 regarding Russia's next move, specifically "A riddle wrapped up in a mystery, inside an enigma," perfectly fits the current understanding of unusual accessory atrioventricular pathways, including the variants producing ventricular pre-excita... |
consider acute st elevation mi ***. sinus rhythm with pvc(s). --- suspect arm lead reversal - only avf, v1-v6 analyzed ---. possible biatrial enlargement. possible extensive infarct - age undetermined. septal st elevation, consider acute infarct. low qrs voltages in precordial leads. abnormal ecg. |
For years, the mammary gland serves as a perfect example to study the self-renew and differentiation of adult stem cells, and the regulatory mechanisms of these processes as well. To assess the function of given genes and/or other factors on stemness of mammary cells, several <i>in vitro</i> assays were developed, such... |
Protein supplements are consumed frequently by athletes and recreationally active adults for various reasons, including improved exercise performance and recovery after exercise. Yet, far too often, the decision to purchase and consume protein supplements is based on marketing claims rather than available evidence-base... |
A decline in mortality rates during the first 12 months of antiretroviral therapy (ART) has been mainly linked to increased ART initiation at higher CD4 counts and at less advanced World Health Organization (WHO) clinical stages of HIV infection; however, the role of improved patient care has not been well studied. We ... |
To assess the possible involvement of catecholaminergic neurotransmitters in maintenance of spatial cognition, the present work investigated the effects of dopaminergic and noradrenergic receptor antagonists on memory performance of rats in a partially baited radial eight-arm maze. Food-deprived rats were first trained... |
Interleukin-7 (IL-7) is a critical cytokine in B- and T-lymphocyte development and maturation. Recent evidence suggests that IL-7 is a preferential homeostatic and survival factor for RORγt<sup>+</sup> innate T cells such as natural killer T (NKT) cells, γδT cells, and mucosal-associated invariant T (... |
sinus rhythm.. left anterior fascicular block. poor r wave progression - probable normal variant. lateral t wave changes are nonspecific. borderline ecg. |
atrial fibrillation with frequent multifocal pvcs or aberrant ventricular conduction.. possible inferior infarct - age undetermined. anterolateral st-t changes are nonspecific. abnormal ecg. |
Epilepsy (Ep) is a chronic neural disease. The diagnosis of epilepsy depends on detailed seizure history and scalp electroencephalogram (EEG) examinations. The automatic recognition of epileptic EEG is an artificial intelligence application developed from machine learning (ML).</AbstractText>This study compares the cla... |
Background Mutations in <i>ATP1A2</i> gene encoding the Na,K-ATPase α<sub>2</sub> isoform are associated with familial hemiplegic migraine type 2. Migraine with aura is a known risk factor for heart disease. The Na,K-ATPase is important for cardiac function, but its role for heart disease remains unknown. We hypo... |
Transcription networks composed of various transcriptional factors specifically expressed in undifferentiated embryonic stem (ES) cells have been implicated in the regulation of pluripotency in ES cells. However, the molecular mechanisms responsible for self-renewal, maintenance of pluripotency, and lineage specificati... |
Neuroimaging allows in vivo visualization of neuronal structures/processes to assess their involvement in bodily functions. This is particularly valuable for the assessment of complex, multilevel neuronal controlled functions, such as urine storage and micturition. Using positron emission tomography or functional magne... |
This study aimed to assess the early effect of trans-catheter aortic valve
implantation (TAVI) on right (RV) and left ventricular (LV) function in severe
aortic stenosis (AS) patients. Twenty AS patients (age 79±6 years) were examined
before, one week and six weeks after TAVI using Doppler echocardiography. LV
ejec... |
Zebra finches show a multifaceted response to playback of tape-recorded birdsong. A novel song induces an overt listening behavior, accompanied by a distinct electrophysiological signature and a wave of gene expression in the auditory telencephalon. With repetition of the same song these responses all habituate; habitu... |
PURPOSE: To report an illustrative case demonstrating the efficacy of
endovascular treatment for traumatic blunt renal allograft injury.
CASE REPORT: A 19-year-old man sustained an injury to his renal allograft after
a traffic accident secondary to lap belt compression. Angiography revealed
contrast extravasation fr... |
BACKGROUND: Vasovagal syncope is one of the most common medical conditions in
young adults. Previous trials have shown effectiveness of tilt training in
treating this condition. We conducted a prospective, randomized study in order
to evaluate the role of tilt-training in young adults with vasovagal syncope.
METHODS... |
Deep brain stimulation (DBS) is one of the most important clinical therapies for neurological disorders. DBS also has great potential to become a great tool for clinical neuroscience research. Recently, the National Engineering Laboratory for Neuromodulation at Tsinghua University held an international Deep Brain Stimu... |
Carotid artery blowout syndrome is a rare complication of head and neck cancer treatment. It defines a rupture of the carotid artery wall through vessel wall necrosis. This is typically precipitated by radiotherapy, direct tumour invasion, or a combination of these factors. We describe a rare case of three consecutive ... |
This study aims to explore the markers of frailty in a "real world" population of MM patients, and to monitor changes to those markers throughout treatment and follow-up. Clinical, physical and biological parameters will be collected by interviewing the patients via questionnaires, physical tests and blood analyses. Al... |
This preliminary study deals with the dynamics of the PR interval during exercise testing by using a Bruce protocol in 31 nonmedicated, normal patients with ages of 33 +/- 14 years. The behavior of the PR interval permitted its categorization into 2 groups. In Group I (27 of 31, 87.1% of patients) the PR interval showe... |
ventricular pacing. pacemaker rhythm - no further analysis. abnormal ecg. |
sinus rhythm. inferior t wave changes are nonspecific. borderline ecg. |
Early diagnosis of congenital heart disease (CHD) can improve the prognosis of neonates with CHD. We retrospectively evaluated the value of prenatal diagnosis of CHD by comparing the pregnancy outcomes. Prenatal diagnosis of CHD was established by echocardiographic evaluation of fetal heart. Amniotic fluid and/or cord ... |
sinus bradycardia. iv conduction defect. inferior infarct - age undetermined. lateral st-t changes may be due to myocardial ischemia. abnormal ecg. |
sinus bradycardia. rsr'(v1) - probable normal variant. lateral st-t changes are nonspecific. borderline ecg. |
sinus rhythm. low qrs voltages in precordial leads. borderline ecg. |
An 18-year-old man with a history of type 3 von Willebrand disease (VWD) presented with a spontaneous pyohaemothorax. Type 3 VWD may present with both mucocutaneous and deep-seated bleeds, such as visceral haemorrhages, intracranial bleeds and haemarthrosis. There have been very few cases described in children of spont... |
Naghavi M, Barlas Z, Siadaty S, Naguib S, Madjid M, Casscells W. Association of influenza vaccination and reduced risk of recurrent myo- cardial infarction. Circulation. 2000;102:3039–3045. 441. Nichol KL, Nordin J, Mullooly J, Lask R, Fillbrandt K, Iwane M. Influenza vaccination and reduction in hospitalizations for c... |
To assess gender differences in in-hospital mortality and 90-day readmission rates among patients undergoing transcatheter aortic valve replacement (TAVR) in the USA.</AbstractText>Hospitalizations for TAVR were retrospectively identified in the National readmissions database (NRD) from 2012 to 2017. Gender based diffe... |
OBJECTIVE: To determine the effect of nitroglycerin on coronary blood flow
velocity during controlled hypotensive anesthesia in humans.
DESIGN: Internally controlled prospective study.
SETTING: Single university hospital.
PARTICIPANTS: Twenty American Society of Anesthesiologists class I and II
patients undergoing ge... |
sinus rhythm.. inferior infarct - age undetermined. abnormal ecg. |
OBJECTIVE: Autologous endothelial cell seeding was used to improve the patency
of 4-mm polytetrafluoroethylene vascular prostheses.
METHODS: Since 1995, 14 patients with coronary artery disease received 21
autologous endothelial cell-seeded polytetrafluoroethylene vascular bypass
grafts for coronary artery revascula... |
The present study compares the senior level operative experience of graduates from the traditional vascular surgery fellowship (5 + 2) and integrated vascular surgery training programs (0 + 5) using contemporary operative case log data.</AbstractText>The Accreditation Council for Graduate Medical Ed... |
sinus rhythm. normal ecg. |
The current attitudes among European bariatric surgeons toward the laparoscopic bariatric operations were examined.</AbstractText>150 questionnaires were sent to recognized bariatric surgeons in Europe, and 60% responded.</AbstractText>47% of respondents perform laparoscopic Roux-en-Y gastric bypass (LRYGBP), 81% lapar... |
To highlight an uncommon problem of heparin induced thrombocytopenia after coronary artery bypass operation.</AbstractText>We report the case of a 59-year-old man who suffered severe type II heparin induced thrombocytopenia (HIT) after coronary artery bypass operation. He experienced extensive skin necrosis at sites of... |
A simplified circuit of modified ultrafiltration (MUF) is described. The technique described is simple, inexpensive, allows both conventional ultrafiltration (CUF) and modified ultrafiltration with minimum manipulation of the circuit, allows re-institution of cardiopulmonary bypass (CPB) in an emergency, reduces the ri... |
age not entered, assumed to be 50 years old for purpose of ecg interpretation. sinus rhythm. |
sinus tachycardia. left atrial enlargement. nonspecific t abnormalities, diffuse leads. prolonged qt interval. |
Recent reports suggest that the COVID-19 lockdown resulted in changes in mental health, however, potential age-related changes and risk factors remain unknown. We measured COVID-19 lockdown-induced stress levels and the severity of depressive symptoms prior to and during the COVID-19 lockdown in different age groups an... |
BACKGROUND: Several lines of evidence support a pathophysiological role of
immunity in atherosclerosis. Tyrosine-nitrated proteins, a footprint of oxygen-
and nitrogen-derived oxidants generated by cells of the immune system, are
enriched in atheromatous lesions and in circulation of patients with coronary
artery d... |
Atherosclerotic plaque progression and rupture are believed to be associated with mechanical stress conditions. In this paper, patient-specific in vivo intravascular ultrasound (IVUS) coronary plaque image data were used to construct computational models with fluid-structure interaction (FSI) and cyclic bending to inve... |
The aim of the present study was to investigate how early the onset of ischaemia-induced changes in gene expression is in remote myocardium, and whether these changes would be different for left and right ventricles. Wistar rats (n=27) were randomly assigned to left coronary artery (LCA) ligation for 30 or 120 min and ... |
Although a lot of studies have  shown serum uric acid (SUA) could be a marker of adverse prognosis in patients with acute myocardial infarction, the role of SUA as a risk factor for myocardial infarction is controversial. This study aimed to evaluate the association between hyperuricemia and short-term outcomes of... |
Bress AP, Colantonio LD, Cooper RS, et al. Potential cardiovascular disease events prevented with adoption of the 2017 American College of Cardi- ology/American Heart Association blood pressure guideline. Circulation. 2019;139:24–36. 21. Bundy JD, Mills KT, Chen J, et al. Estimating the association of the 2017 and 2014... |
OBJECTIVES: The purpose of this study was to determine whether the speed of
response to clopidogrel loading predicts the final degree of response.
BACKGROUND: Fast inhibition of platelet aggregation is important in the setting
of acute coronary syndromes and percutaneous coronary intervention, but its
association wi... |
atrial fibrillation. leftward axis. possible inferior infarct - age undetermined. anterior t wave changes are nonspecific. abnormal ecg. |
This study was designed to determine the effect of all-trans retinoic acid (RA)
on the development of cardiac remodeling in a pressure overload rat model. Male
Sprague-Dawley rats were subjected to sham operation and the aortic constriction
procedure. A subgroup of sham control and aortic constricted rats were treat... |
When there is an echocardiographic diagnosis of severe mobile atherosclerotic
plaque in the aortic arch or descending aorta, perfusion toward the aortic arch
during cardiopulmonary bypass may create a high risk of embolic neurologic
injury. Other perfusion methods, such as cannulation of the femoral or axillary
art... |
sinus rhythm. normal ecg. |
To help ensure successful outcomes of open-heart surgery, surgeon and perfusionist must coordinate their activities during management of cardioplegia. This research aims to understand the basis for this coordination. We employed the framework of distributed cognition and the methodology of cognitive ethnography to desc... |
sinus rhythm. normal ecg. |
Transient episodes of ischemia in a remote organ (remote ischemic preconditioning, RIPC) bears the potential to attenuate myocardial injury, but the underlying mechanisms are only poorly understood. In the pilot experimental study presented we investigated cellular and molecular effects of RIPC in heart tissue of cardi... |
atrial fibrillation. inferior/lateral st-t changes are nonspecific. abnormal ecg. |
Prior trials provide strong evidence supporting minimally invasive sacroiliac joint (SIJ) fusion using triangular titanium implants (TTI) for chronic SIJ dysfunction.</AbstractText>To assess the safety and effectiveness of SIJF using a 3D-printed TTI.</AbstractText>Fifty-one subjects with carefully diagnosed SIJ dysfun... |
A 38-year-old Caucasian man with a medical history significant for inflammatory bowel disease (IBD) and mesalamine use presented to the emergency department with stabbing, pleuritic, substernal chest pain over the previous 2 days. Findings of leucocytosis, elevated cardiac enzymes and inflammatory markers, T-wave or ST... |
Catheter-related right atrial thrombus (RAT) is an uncommon life-threatening complication. Few cases of endovascular cooling catheter–related complications have been reported. We report the first case of endovascular cooling catheter–related RAT. A 17-year-old adolescent boy was treated with therapeutic h... |
Childhood obesity is associated with cardiovascular risk factors. Being at risk for overweight has been defined as having a body mass index (BMI) between the 85th and 94th percentile for age and sex. In this study, we investigate the aortic and pulmonary artery stiffness and left and right ventricular function in child... |
ventricular pacing. pacemaker rhythm - no further analysis. abnormal ecg. |
sinus rhythm with borderline 1st degree a-v block. borderline ecg. |
The incidence of cardiac arrhythmias is estimated et 1.2 per 1000 pregnancies, usually in the third trimester and 50% of them are asymptomatic. They may appear for the first time in pregnancy or have a recurring character An important risk factor related to their appearance is the presence of structural heart disease, ... |
Classic G-quadruplex binders typically have a large aromatic core and interact with G-quadruplexes through π-π stacking with the quartets. There are rather few reports on natural flexible cyclic molecule from traditional Chinese medicine which has high binding affinity with G-quadruplex.</AbstractText>Elect... |
Darier disease is an autosomal dominant skin disorder caused by mutations in the ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 (ATP2A2) gene and previously reported to cosegregate with bipolar disorder and schizophrenia in occasional pedigrees. It is, however, unknown whether these associations exist also in... |
Neonatal diabetes mellitus (NDM) is a rare monogenic diabetes form, occurring mainly from ATP-binding cassette subfamily C member 8 (ABCC8</i>) and KCNJ11</i> mutations. ABCC8</i> mutations have also been found to cause adult-onset diabetes. What is new?: •Novel ABCC8</i> mutation in an NDM case •Heteroge... |
A substantial increase in chronic cardiovascular disease is projected for the next several decades. This is attributable to an aging population and accelerated rates of obesity and diabetes. Despite technological advances that have improved survival for acute events, there is suboptimal translation of research knowledg... |
Type I diabetes is associated with vascular endothelial abnormalities.
Vasoactive mediators such as endothelins and reactive oxygen species are
modulated in diabetic patients. We studied the hemodynamic profile and the
release of mediators alongside the onset of streptozotocin-induced type I
diabetes in rats. Arter... |
This paper presents a new approach for confidence interval estimation of the between-study variance in meta-analysis with normally distributed responses based on the concepts of generalized variables. Simulation study shows that the coverage probabilities of the proposed confidence intervals are generally satisfactory.... |
AIM: Neuromuscular blockade may improve outcomes in patients with acute
respiratory distress syndrome. In post-cardiac arrest patients receiving
therapeutic hypothermia, neuromuscular blockade is often used to prevent
shivering. Our objective was to determine whether neuromuscular blockade is
associated with improv... |
sinus rhythm. normal ecg. |
Chronic rhinosinusitis (CRS) is a heterogeneous disease at the clinical phenotype level (without nasal polyp [CRSsNP] vs with nasal polyp [CRSwNP]) and at the underlying inflammatory endotype level (type 2 vs non-type 2). Whether the endotype is associated with clinical presentation in patients with CRSsNP has yet to b... |
Solitary fibrous tumors (SFTs) are rare tumors thought to be of mesenchymal origin. Even though intracranial, especially intraventricular, SFTs are rare, this diagnosis should be considered in the differential for intraventricular lesions. Here, report the case of a female in her 60s who underwent a non-contrast-enhanc... |
The postthrombotic syndrome counts as a frequent long-term complication after deep vein thrombosis with approximately 20%-50% of affected patients after deep vein thrombosis. The earliest that diagnosis of postthrombotic syndrome can be made is 6 months after deep vein thrombosis. Most patients suffer from swelling and... |
sinus rhythm. normal ecg. |
BACKGROUND: The transthoracic echocardiographic (TTE) evaluation of the severity
of residual aortic regurgitation (AR) following transcatheter aortic valve
implantation (TAVI) has been controversial and lacks validation.
OBJECTIVES: This study sought to compare TTE and cardiac magnetic resonance
(CMR) for assessment... |
Vitamin E includes eight natural antioxidant compounds (four tocopherols and four tocotrienols), but α-tocopherol has been the main focus of investigation in studies of cognitive impairment and Alzheimer's disease.</AbstractText>To investigate the association between serum levels of tocopherols and tocotrienols, ... |
The secundum atrial septal defect (ASD II) is, after bicuspid aortic valve, the second most frequent congenital heart disease. In the majority of females with ASD II the course of pregnancy is uncomplicated, however, pregnancy-related cardiovascular changes may affect hemodynamic parameters of the defect.</AbstractText... |
We studied association of single-nucleotide SCN5A (rs1805124), GJA5 (rs35594137), and KCNN3 (rs13376333) polymorphisms and sudden cardiac death. Humans died suddenly from cardiac causes (N=379) and unrelated sex- and age-matched control subjects were genotyped. No significant intergroup differences were found in the fr... |
atrial fibrillation with pvc(s).. possible anterior infarct - age undetermined. generalized low qrs voltages. abnormal ecg. |
sinus rhythm.. inferior/lateral t wave changes are nonspecific. borderline ecg. |
sinus rhythm. probable left atrial enlargement. left ventricular hypertrophy. abnormal t, consider ischemia, lateral leads. anterior st elevation, probably due to lvh. |
In a rabbit model of Streptococcus pneumoniae meningitis, 5 mg of gemifloxacin mesylate (SB-265805) per kg/h reduced the bacterial titers in cerebrospinal fluid (CSF) almost as rapidly as 10 mg of ceftriaxone per kg/h (Deltalog CFU/ml/h +/- standard deviation [SD], -0.25 +/- 0.09 versus -0.38 +/- 0.11; serum and CSF co... |
The aim of this study was to determine predictors of cardiac morbidity and
mortality in patients undergoing endovascular repair of the thoracic aorta. This
was a retrospective cohort study that took place in a University-affiliated
county hospital. Preoperative and intraoperative variables were collected from a
con... |
A novel and simple method based on solidified floating organic drop microextraction followed by high-performance liquid chromatography with ultraviolet detection has been developed for simultaneous preconcentration and determination of phenobarbital, lamotrigine, and phenytoin in human plasma and urine samples. Factors... |
Segmentation and registration tools are commonly used in radiotherapy for target and at risk organs localisation. In this work the performances of three different segmentation tools and of a surface matching registration technique, used on computed tomography (CT) and magnetic resonance (MR) images for the treatment pl... |
We describe a case of relentless placoid chorioretinitis (RPC) that progressed despite administration of peribulbar and systemic corticosteroids, and was resolved by systemic combined with intravitreal methotrexate.</AbstractText>A 16-year-old male reported painless blurred vision and a temporal scotoma in his right ey... |
Amiodarone is an effective antiarrhythmic drug for supra­ven­tri­cular and ventricular arrhythmias. A majority of patients treated with amiodarone suffer from mild adverse events, however, serious life-threatening adverse events caused by amiodarone are also seen. This review describes the pharmacology, ... |
Heart failure is a highly prevalent disorder associated with increased mortality, repeated and lengthy hospitalization, and disability. Major progress has been made in the treatment of chronic heart failure associated with a reduced ejection fraction, through the development of neuromodulators such as angiotensin-conve... |
sinus rhythm. normal ecg. |
Immunoperoxidase techniques for demonstration of complement split product C4d on paraffin-embedded endomyocardial biopsy samples have been used for the evaluation of humoral rejection mainly in adult heart transplantation. Interpretation of suspected humoral rejection in children requires knowledge of the pattern and f... |
Nucleoside transporters that mediate cellular uptake of therapeutic nucleoside analogs are major determinants of the pharmacokinetic properties of these compounds. Understanding the substrate selectivity of these transporters is critical in the development of therapeutic nucleoside analogs with optimal pharmacokinetic ... |
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