immunogenicity: legacy arms, and species keyed on the restricting allele
Browse filesThe Calis deposit's Species column is the host, not the restriction, and they disagree on 31% of its
rows -- HLA-transgenic mice. Keyed on the allele its human arm is 1,619 immunogenic against 272, not
1,113 against one.
immunogenicity/SOURCES.md
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tested is assumed non-immunogenic. 38,322 rows in the rebuild have a measured negative T-cell assay
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instead, held under evidence `tcell_negative` and deliberately **not** merged into the arm: swapping
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the negative definition changes what every AUROC recorded on these corpora means.
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tested is assumed non-immunogenic. 38,322 rows in the rebuild have a measured negative T-cell assay
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instead, held under evidence `tcell_negative` and deliberately **not** merged into the arm: swapping
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the negative definition changes what every AUROC recorded on these corpora means.
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### `immunogenicity_legacy_arms.tsv.gz` (2026-08-19)
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The published deposits and the legacy Kešmir arms in one table, keyed `corpus` ∈ {`chowell_vanilla`,
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`kesmir_S1`, `kesmir_S2`, `kesmir_S3`}, so a held-out evaluation can be reproduced without the
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copyrighted spreadsheets. 15,991 rows.
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**Species is keyed on the restricting allele, not on the deposit's own `Species` column.** The two
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disagree on 777 of the 2,508 Calis rows (31%), which carry `Species = Mus` with an HLA restriction —
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HLA-transgenic mice, murine host and human restricting molecule. Both readings describe the
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experiment; they build different corpora. Keyed on the host, the Calis human arm is 1,113
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immunogenic against **one** non-immunogenic; keyed on the allele it is **1,619 against 272** and the
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mouse arm is H-2 throughout. The reported host is retained as `host_reported`.
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Regenerate with `bench/neoag/corpus_legacy.py` then `deposit_arms.py`.
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### What the recognition model is fitted on
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`chowell_iedb_full` is the training arm for `mhcmatch.recognition` (0.15.0). Two choices were made
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by measurement and are recorded in `bench/results/recognition_model.md` and
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`feature_importance.md`:
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- **The unmatched arm ships.** Resampling negatives to match population HLA usage costs 0.019
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(human) and 0.058 (mouse) AUROC on held-out published deposits.
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- **ESM2 and the physicochemical features are both kept.** ESM2 adds +0.022/+0.042 over physchem
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alone; physchem adds +0.009/+0.019 over ESM2 alone. Permutation importance on held-out data ranks
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the two ESM face-pools first (0.19–0.27), then `kf_tcr`; the whole-peptide Kidera aggregate is
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worth 0.0165/0.0012 and is not shipped, being exactly the sum of the two role columns.
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immunogenicity/chowell_iedb_full.tsv.gz
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immunogenicity/chowell_iedb_full_matched.tsv.gz
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immunogenicity/immunogenicity_legacy_arms.tsv.gz
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size 119696
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