pubmedid int64 32.7M 39M | language stringclasses 12
values | title stringlengths 15 300 | abstract stringlengths 73 5.85k | termIds stringlengths 22 295 |
|---|---|---|---|---|
38,960,662 | jpn | [Challenges and strategies for improving efficacy in CAR-T therapy]. | CAR-T cell therapy targeting CD19 and BCMA for relapsed or refractory hematopoietic tumors has been adopted in routine practice and has shown dramatic results. However, half of patients who achieve remission with CAR-T therapy eventually relapse, and thus efforts to improve the efficacy of CAR-T therapy are gaining mom... | ['D006801', 'D016219', 'D019337', 'D018941', 'D016896', 'D000076962'] |
38,960,659 | jpn | [Coagulation and complement crosstalk: molecular mechanisms of complement-mediated diseases]. | The complement and coagulation systems are ancestrally related mechanisms of serine protease-induced protein activation. Recent studies have shown that the complement system enhances platelet aggregation by activating platelets and vascular endothelial cells. This system is also involved in the expression of tissue fac... | ['D006801', 'D003167', 'D003165', 'D001777', 'D013927', 'D000818'] |
38,960,658 | jpn | [Advances in the treatment of thrombotic thrombocytopenic purpura]. | Thrombotic thrombocytopenic purpura (TTP) is a fatal thrombotic disease caused by a marked decrease in the activity of ADAMTS13, a von Willebrand factor cleaving protease. In congenital TTP, ADAMTS13 activity is decreased by an abnormality in ADAMTS13, and in acquired TTP, by anti-ADAMTS13 autoantibody. Death from thro... | ['D011697', 'D006801', 'D000071120', 'D010951', 'D015316', 'D061905'] |
38,960,657 | jpn | [Novel treatment strategies for acquired hemophilia A]. | Acquired hemophilia A (AHA) is a bleeding disorder caused by autoantibody (inhibitor) production targeting blood coagulation factor VIII (FVIII). It is characterized by sudden onset, and often causes extensive and severe bleeding in soft tissue. Acquired hemophilia A is diagnosed when coagulation tests show normal PT, ... | ['D006467', 'D006801', 'D005169', 'D018033', 'D007166', 'D061067'] |
38,960,655 | jpn | [Novel therapies for multiple myeloma]. | B-cell maturation antigen (BCMA)-targeting therapy is the most common approach to immunotherapy and cellular therapy for multiple myeloma (MM). Three major agents, CAR-T cells, bispecific antibodies, and ADC have been developed as novel therapeutic agents. CAR-T therapy showed favorable efficacy in the treatment of rel... | ['D009101', 'D006801', 'D018033', 'D053301', 'D007167', 'D058990', 'D016219'] |
38,960,654 | jpn | [CAR T-cell therapy for malignant lymphoma]. | Advances in understanding of the pathogenesis of B-cell lymphoma have led to development of various novel targeted therapies. Among them, CD19-targeted chimeric antigen receptor (CAR) T-cell therapies for relapsed and refractory B-cell lymphomas have shown remarkable efficacy in clinical trials, and three CAR T-cell pr... | ['D006801', 'D016219', 'D008223', 'D000076962', 'D002986', 'D016393'] |
38,960,645 | jpn | [TCL1-family negative T-cell prolymphocytic leukemia with rapid progression of extranodal disease despite a normal white blood cell count]. | Here we describe the case of a 69-year-old man who was found to have moderate thrombocytopenia and severe splenomegaly during a medical checkup at the age of 67. At the first visit, his white blood cell (WBC) count was 7,400/µl with 80% lymphocytes, and bone marrow aspiration showed 24% atypical lymphocytes. Flow cytom... | ['D006801', 'D008297', 'D000368', 'D018450', 'D015461', 'D007958', 'D011518'] |
38,960,623 | eng | Roles of Tubulin Concentration during Prometaphase and Ran-GTP during Anaphase of Caenorhabditis elegans Meiosis. | In many animal species, the oocyte meiotic spindle, which is required for chromosome segregation, forms without centrosomes. In some systems, Ran-GEF on chromatin initiates spindle assembly. We found that in Caenorhabditis elegans oocytes, endogenously-tagged Ran-GEF dissociates from chromatin during spindle assembly b... | ['D000818', 'D017173', 'D014404', 'D008941', 'D000705', 'D029742', 'D009865', 'D049468', 'D008540', 'D020931', 'D006160', 'D002843', 'D020090'] |
38,960,622 | eng | Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation. | A pleiotropic immunoregulatory cytokine, TGF-β, signals via the receptor-regulated SMADs: SMAD2 and SMAD3, which are constitutively expressed in normal cells. Here, we show that selective repression of SMAD3 induces cDC differentiation from the CD115+ common DC progenitor (CDP). SMAD3 was expressed in haematopoietic ce... | ['D000818', 'D002454', 'D003713', 'D051900', 'D050796', 'D051379', 'D050835', 'D051797', 'D018345', 'D008810', 'D051941', 'D011518', 'D051899', 'D010766', 'D015398'] |
38,960,510 | eng | Impact of Lipoprotein(a) Level on Low-Density Lipoprotein Cholesterol- or Apolipoprotein B-Related Risk of Coronary Heart Disease. | Conventional low-density lipoprotein cholesterol (LDL-C) quantification includes cholesterol attributable to lipoprotein(a) (Lp(a)-C) due to their overlapping densities. | ['D006801', 'D017270', 'D008078', 'D008297', 'D005260', 'D003327', 'D008875', 'D001055', 'D000368', 'D000328', 'D012307', 'D018570', 'D015994'] |
38,960,508 | eng | Comparative Cardiovascular Benefits of Bempedoic Acid and Statin Drugs. | In the CLEAR (Cholesterol Lowering via Bempedoic Acid, an ACL-Inhibiting Regimen) Outcomes trial, treatment of statin-intolerant patients with bempedoic acid produced a 21% decrease in low-density lipoprotein cholesterol (LDL-C) relative to placebo and a 13% relative reduction in the risk of major adverse cardiovascula... | ['D006801', 'D008297', 'D019161', 'D005260', 'D008875', 'D003998', 'D005227', 'D008078', 'D000368', 'D002318', 'D016896', 'D004311'] |
38,960,495 | eng | Social Induction via a Social Behavioral Intervention on Changes in Metabolic Risk Factors: A Randomized Controlled Trial in Rural Appalachia, United States. | To conduct a randomized controlled trial examining the effects of a social network intervention on health. | ['D006801', 'D008297', 'D005260', 'D001061', 'D008875', 'D012424', 'D000328', 'D006442', 'D055105', 'D001794'] |
38,960,488 | eng | A model of microtubule depolymerization by kinesin-8 motor proteins. | The dimeric kinesin-8 motors have the biological function of depolymerizing microtubules (MTs) from the plus end. However, the molecular mechanism of the depolymerization promoted by the kinesin-8 motors is still undetermined. Here, a model is proposed for the MT depolymerization by the kinesin-8 motors. Based on the m... | ['D016547', 'D008870', 'D058105', 'D006801', 'D000818'] |
38,960,487 | eng | Metalloproteins structural and functional insights into immunological patterns. | Metalloproteins play a crucial role in regulating different aspects of the immune system in humans. They have various functions in immunity, including recognizing and presenting antigens, aiding in the movement and effectiveness of immune cells, and facilitating interactions between the host and pathogens. Understandin... | ['D006801', 'D008667', 'D000818'] |
38,960,485 | eng | Exploring metalloproteins found in the secretion of venomous species: Biological role and therapeutical applications. | Several species during evolution suffered random mutations in response to various environmental factors, which resulted in the formation of venom in phylogenetically distant species. The composition of the venom of most species is poorly known. Snake venom is well characterized while most species have poorly known comp... | ['D000818', 'D006801', 'D012910', 'D008667'] |
38,960,484 | eng | Gut microbial metalloproteins and its role in xenobiotics degradation and ROS scavenging. | The gut microbial metalloenzymes play an important role in maintaining the balance between gut microbial ecosystem, human physiologically processes and immune system. The metals coordinated into active site contribute in various detoxification and defense strategies to avoid unfavourable environment and ensure bacteria... | ['D015262', 'D006801', 'D000069196', 'D008667', 'D017382'] |
38,960,483 | eng | G-protein coupled receptors regulates Tauopathy in neurodegeneration. | In Alzheimer's disease, the microtubule-associated protein, Tau misfolds to form aggregates and filaments in the intra- and extracellular region of neuronal cells. Microglial cells are the resident brain macrophage cells involved in constant surveillance and activated by the extracellular deposits. Purinergic receptors... | ['D006801', 'D024801', 'D016875', 'D017628', 'D058925', 'D000818', 'D043562'] |
38,960,482 | eng | The crosstalk between extracellular matrix proteins and Tau. | Alzheimer's disease is progressive neurodegenerative disease characterize by the presence of extracellular accumulation of amyloid-β plaques and intracellular deposits of neurofibrillary tangles of Tau. Apart from axonal depositions pathological aggregated Tau protein is known to secrete into extracellular spaces and p... | ['D016875', 'D006801', 'D016326', 'D000544', 'D010587', 'D000818', 'D015525', 'D017628'] |
38,960,480 | eng | Vesicle transport of matrix metalloproteinases. | Multicellular organisms consist of cells and extracellular matrix (ECM). ECM creates a cellular microenvironment, and cells locally degrade the ECM according to their cellular activity. A major group of enzymes that modify ECM belongs to matrix metalloproteinases (MMPs) and play major roles in various pathophysiologica... | ['D020782', 'D006801', 'D000818', 'D016547', 'D005109', 'D001692', 'D008870'] |
38,960,479 | eng | Long-term culture of patient-derived mammary organoids in non-biogenic electrospun scaffolds for identifying metalloprotein and motor protein activities in aging and senescence. | We recently identified TMEM230 as a master regulator of the endomembrane system of cells. TMEM230 expression is necessary for promoting motor protein dependent intracellular trafficking of metalloproteins for cellular energy production in mitochondria. TMEM230 is also required for transport and secretion of metalloprot... | ['D006801', 'D009940', 'D000375', 'D008565', 'D016922', 'D005260', 'D054457', 'D042361'] |
38,960,478 | eng | Single-cell transcriptomic analysis to identify endomembrane regulation of metalloproteins and motor proteins in autoimmunity. | TMEM230 promotes antigen processing, trafficking, and presentation by regulating the endomembrane system of membrane bound organelles (lysosomes, proteosomes and mitochondria) and phagosomes. Activation of the immune system requires trafficking of various cargos between the endomembrane system and cell plasma membrane.... | ['D006801', 'D008667', 'D059010', 'D015551', 'D008565', 'D000818', 'D020869'] |
38,960,477 | eng | Transmembrane protein TMEM230, regulator of metalloproteins and motor proteins in gliomas and gliosis. | Glial cells provide physical and chemical support and protection for neurons and for the extracellular compartments of neural tissue through secretion of soluble factors, insoluble scaffolds, and vesicles. Additionally, glial cells have regenerative capacity by remodeling their physical microenvironment and changing ph... | ['D006801', 'D008565', 'D005910', 'D005911', 'D000818', 'D018000'] |
38,960,476 | eng | The mechanistic insights into different aspects of promiscuity in metalloenzymes. | Enzymes are nature's ultimate machinery to catalyze complex reactions. Though enzymes are evolved to catalyze specific reactions, they also show significant promiscuity in reactions and substrate selection. Metalloenzymes contain a metal ion or metal cofactor in their active site, which is crucial in their catalytic ac... | ['D008667', 'D004798', 'D013379', 'D008670', 'D020134', 'D010084'] |
38,960,472 | eng | Metalloproteins and metalloproteomics in health and disease. | Metalloproteins represents more than one third of human proteome, with huge variation in physiological functions and pathological implications, depending on the metal/metals involved and tissue context. Their functions range from catalysis, bioenergetics, redox, to DNA repair, cell proliferation, signaling, transport o... | ['D006801', 'D008667', 'D040901', 'D009369', 'D019636'] |
38,960,471 | eng | Transcriptomic analysis reveals zinc-mediated virulence and pathogenicity in multidrug-resistant Acinetobacter baumannii. | Acinetobacter baumannii is a gram-negative bacterium well known for its multidrug resistance and connection to nosocomial infections under ESKAPE pathogens. This opportunistic pathogen is ubiquitously associated with nosocomial infections, posing significant threats within healthcare environments. Its critical clinical... | ['D040981', 'D015032', 'D024901', 'D014774', 'D006801', 'D020869', 'D059467', 'D000151', 'D001426'] |
38,960,469 | eng | Effects of almond consumption compared with the consumption of traditional isocaloric cereal/pulse-based snacks on glycaemic control and gut health in adults with pre-diabetes in rural India: protocol for a 16-week, parallel-arm, cluster randomised controlled trial. | Almonds have prebiotic potential to maintain gut health and regulate glycaemia. Western studies have shown their positive effects on preventing non-communicable diseases like diabetes and cardiovascular diseases. However, there is a lack of research involving Asian Indians, who have a higher predisposition to diabetes ... | ['D006801', 'D007194', 'D000328', 'D000068181', 'D005260', 'D008297', 'D008875', 'D011236', 'D000085002', 'D016032', 'D062410', 'D055815', 'D002523', 'D012424', 'D001786', 'D006442'] |
38,960,465 | eng | Same-visit hepatitis C testing and treatment to accelerate cure among people who inject drugs (the QuickStart Study): a cluster randomised cross-over trial protocol. | Despite universal access to government-funded direct-acting antivirals (DAAs) in 2016, the rate of hepatitis C treatment uptake in Australia has declined substantially. Most hepatitis C is related to injecting drug use; reducing the hepatitis C burden among people who inject drugs (PWID) is, therefore, paramount to rea... | ['D006801', 'D000998', 'D018592', 'D015819', 'D006526', 'D001315', 'D016032', 'D018937', 'D016174'] |
38,960,429 | eng | Malignancy and mass-forming phenotypes of IgG4-related disease: a challenging diagnosis. | Mass-forming phenotypes of IgG4-related disease (IgG4-RD) mimic malignancy and histological confirmation can be challenging. A woman in her 70s with HIV infection presented with painless obstructive jaundice and weight loss. Magnetic resonance imaging was suggestive of unresectable cholangiocarcinoma. Tumour markers an... | ['D006801', 'D005260', 'D000077733', 'D003937', 'D010190', 'D000368', 'D018281', 'D017809', 'D010641', 'D007074', 'D008279', 'D041781', 'D014057', 'D001650', 'D006104'] |
38,960,425 | eng | Measles in the vaccinated host. | A woman in her 40s known to have systemic lupus erythematosus presented with a maculopapular rash on her face, neck and chest following measles exposure. She had received a single-dose measles vaccine as a child in the 1970s and was therefore presumed to be immune, and thus not infectious. As a result, she was initiall... | ['D006801', 'D008457', 'D005260', 'D008458', 'D000328', 'D008459', 'D022542', 'D008180', 'D014611', 'D008875', 'D000914', 'D007075'] |
38,960,420 | eng | Budd-Chiari syndrome associated with congenital afibrinogenaemia reversed after orthotopic liver transplant. | A woman in her mid-20s, a known case of congenital afibrinogenaemia, presented with abdominal pain and distension. She was diagnosed with decompensated liver cirrhosis due to Budd-Chiari syndrome. She underwent deceased donor liver transplantation. Preoperatively, her serum fibrinogen level was undetectable and prothro... | ['D006801', 'D006502', 'D016031', 'D000347', 'D005260', 'D000328', 'D008103', 'D005340', 'D019934'] |
38,960,415 | eng | Effect of ripasudil after trabeculectomy with mitomycin C: a multicentre, randomised, prospective clinical study. | To investigate if there are improvements in trabeculectomy outcomes supporting filtration bleb formation caused by Rho-associated protein kinase (ROCK) inhibitors. | ['D006801', 'D014130', 'D008297', 'D007429', 'D011446', 'D005260', 'D005902', 'D007546', 'D000368', 'D013449', 'D016685', 'D008875', 'D054460', 'D016896', 'D000477'] |
38,960,409 | eng | Antibody design using deep learning: from sequence and structure design to affinity maturation. | Deep learning has achieved impressive results in various fields such as computer vision and natural language processing, making it a powerful tool in biology. Its applications now encompass cellular image classification, genomic studies and drug discovery. While drug development traditionally focused deep learning appl... | ['D000077321', 'D000906', 'D006801', 'D000915', 'D019295', 'D015195'] |
38,960,407 | eng | AttABseq: an attention-based deep learning prediction method for antigen-antibody binding affinity changes based on protein sequences. | The optimization of therapeutic antibodies through traditional techniques, such as candidate screening via hybridoma or phage display, is resource-intensive and time-consuming. In recent years, computational and artificial intelligence-based methods have been actively developed to accelerate and improve the development... | ['D000077321', 'D000936', 'D000941', 'D000915', 'D000595', 'D019295', 'D006801', 'D009154', 'D000906'] |
38,959,931 | eng | Refractory chronic spontaneous urticaria after heterologous COVID-19 booster vaccination. | Chronic spontaneous urticaria (CSU) involves recurrent, pruritic wheals lasting more than 6 weeks in response to various etiologies, including unknown causality. Though most cutaneous reactions to the COVID-19 vaccine series are self-limited and of short duration, more complex presentations including chronic spontaneou... | ['D006801', 'D000080223', 'D000086663', 'D007117', 'D000090982', 'D005260', 'D000069444', 'D000086382', 'D008875', 'D008297', 'D000328'] |
38,959,927 | eng | Drug-Induced dermatomyositis following COVID-19 vaccination. | Dermatomyositis (DM) is a multi-organ idiopathic inflammatory myopathy that presents with proximal symmetric muscle weakness accompanied by characteristic cutaneous findings. Most individuals present with skin manifestations prior to muscle involvement and its course can involve the blood vessels, joints, esophagus, an... | ['D006801', 'D003882', 'D008297', 'D008875', 'D000086663', 'D000090982', 'D000086382'] |
38,959,923 | eng | Generalized Hailey-Hailey disease associated with c.2395C>T ATP2C1 gene mutation and fatal outcome. | Hailey-Hailey disease (HHD) is a rare, autosomal dominant genodermatosis caused by a mutation of the ATP2C1 gene and presenting as an erosive dermatosis, particularly in the intertriginous areas. Generalized HHD is a rare variant. We present a case of widespread, recalcitrant HHD in a middle-aged woman with a fatal out... | ['D006801', 'D016506', 'D005260', 'D000252', 'D008875', 'D017809', 'D009154'] |
38,959,917 | eng | Squamoid eccrine ductal carcinoma: clinical, histological and immunohistochemical features. | Squamoid eccrine ductal carcinoma (SEDC) is a cutaneous adnexal malignancy that is histologically challenging to distinguish from squamous cell carcinoma. We report three cases of this rare entity and review the present literature regarding clinical, histological, and immunohistochemical features. Patients presented wi... | ['D006801', 'D008297', 'D002294', 'D013544', 'D000368', 'D005260', 'D004439', 'D044584', 'D000369', 'D007150', 'D012878', 'D002272', 'D003937', 'D018396', 'D008875'] |
38,959,915 | eng | Merkel cell carcinoma associated with TNF inhibitor therapy: a systematic review of case reports. | A rare neuroendocrine skin cancer called Merkel cell carcinoma (MCC) primarily affects elderly people. The objective of this study is to comprehensively review the impact of immunosuppressive medications, particularly TNF inhibitors, on the emergence of MCC. | ['D006801', 'D015266', 'D012878', 'D008875', 'D000079424', 'D000068800', 'D000368', 'D005260', 'D008297', 'D000069285', 'D000911', 'D000068879', 'D000328', 'D007166', 'D001172', 'D014409'] |
38,959,864 | eng | Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease. | Population-level variation and mechanisms behind insulin secretion in response to carbohydrate, protein, and fat remain uncharacterized. We defined prototypical insulin secretion responses to three macronutrients in islets from 140 cadaveric donors, including those with type 2 diabetes. The majority of donors' islets e... | ['D006801', 'D000078790', 'D040901', 'D003924', 'D008297', 'D005260', 'D007328', 'D007515', 'D008875', 'D000078622', 'D000328', 'D005947', 'D000368', 'D005227'] |
38,959,859 | eng | From whence it came: Mitochondrial mRNA leaves, a protein returns. | Small peptides have previously been reported to be encoded in mitochondrial rRNA and translated by cytosolic ribosomes. In this issue of Cell Metabolism, Hu et al. use mass spectrometry to identify a cytosolically translated protein, encoded instead in mitochondrial mRNA, that is surprisingly targeted back into the mit... | ['D012333', 'D008928', 'D000077278', 'D014176', 'D024101', 'D006801', 'D003600', 'D013058'] |
38,961,353 | eng | JARID2, a novel regulatory factor, promotes cell proliferation, migration, and invasion in oral squamous cell carcinoma. | Accurate regulation of gene expression is crucial for normal development and function of cells. The prognostic significance and potential carcinogenic mechanisms of the related gene JARID2 in OSCC are not yet clear, but existing research has indicated a significant association between the two. | ['D006801', 'D009062', 'D049109', 'D002465', 'D011379', 'D045744', 'D009361', 'D015972', 'D005260', 'D008297', 'D063151', 'D002294', 'D008875', 'D014408', 'D055785'] |
38,961,351 | eng | Association of selected adipokines with vitamin D deficiency in children with inflammatory bowel disease. | Adipose tissue is significantly involved in inflammatory bowel disease (IBD). Vitamin D can affect both adipogenesis and inflammation. The aim of this study was to compare the production of selected adipokines, potentially involved in the pathogenesis of IBD - adiponectin, resistin, retinol binding protein 4 (RBP-4), a... | ['D006801', 'D014808', 'D008297', 'D005260', 'D002648', 'D016022', 'D054392', 'D000293', 'D014807', 'D054839', 'D052243', 'D000080866', 'D052242', 'D002135', 'D050556', 'D004268', 'D015415', 'D015212'] |
38,961,336 | eng | Cytokines assets in PLWH in two-drug dolutergravir based or three-drug antiretroviral regimen. | To minimize the toxicity and impact of combined antiretroviral therapy (cART) on the lifestyle of people living with Human Immunodeficiency Virus (PLWH), scientific community evaluated the efficacy, safety and sustained virologic response of two drugs antiretroviral regimens, in particular dolutegravir (DTG). The effec... | ['D006801', 'D015658', 'D016207', 'D008297', 'D005260', 'D000328', 'D008875', 'D006575', 'D010078', 'D010879', 'D011728', 'D019562', 'D004359', 'D019380', 'D018791'] |
38,961,325 | eng | WTAP/IGF2BP3-mediated GBE1 expression accelerates the proliferation and enhances stemness in pancreatic cancer cells via upregulating c-Myc. | Pancreatic cancer (PC) is one of the most malignant cancers with highly aggressiveness and poor prognosis. N6-methyladenosine (m6A) have been indicated to be involved in PC development. Glucan Branching Enzyme 1 (GBE1) is mainly involved in cell glycogen metabolism. However, the function of GBE1 and Whether GBE1 occurs... | ['D006801', 'D049109', 'D016601', 'D016271', 'D045744', 'D000818', 'D014411', 'D010190', 'D015972', 'D051379', 'D015854', 'D008819', 'D011379'] |
38,961,317 | eng | HCN channels in the lateral habenula regulate pain and comorbid depressive-like behaviors in mice. | Comorbid anxiodepressive-like symptoms (CADS) in chronic pain are closely related to the overactivation of the lateral habenula (LHb). Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have been implicated to play a key role in regulating neuronal excitability. However, the role of HCN channels in the ... | ['D000818', 'D019262', 'D064428', 'D051379', 'D008297', 'D003863', 'D009437', 'D008810', 'D059350', 'D015221'] |
38,961,268 | eng | A CRISPR/Cas9 screen in embryonic stem cells reveals that Mdm2 regulates totipotency exit. | During early embryonic development, the transition from totipotency to pluripotency is a fundamental and critical process for proper development. However, the regulatory mechanisms governing this transition remain elusive. Here, we conducted a comprehensive genome-wide CRISPR/Cas9 screen to investigate the 2-cell-like ... | ['D000818', 'D064113', 'D051379', 'D051736', 'D000066450', 'D002454', 'D044127', 'D018507'] |
38,961,264 | eng | Sex differences in PD-L1-induced analgesia in paclitaxel-induced peripheral neuropathy mice depend on TRPV1-based inhibition of CGRP. | Paclitaxel (PTX) is extensively utilized in the management of diverse solid tumors, frequently resulting in paclitaxel-induced peripheral neuropathy (PIPN). The present study aimed to investigate sex differences in the behavioral manifestations and underlying pathogenesis of PIPN and search for clinically efficacious i... | ['D000818', 'D017239', 'D008297', 'D005260', 'D051379', 'D015740', 'D008810', 'D050916', 'D060890', 'D012727', 'D010523', 'D000972', 'D013116', 'D006930'] |
38,961,253 | eng | Protein and fat intake impact on growth of primary school girls in Kerman, Iran. | The school age period is characterized by significant physical and intellectual growth, necessitating the monitoring of macronutrient intake and its impact on weight and height. The objective of this study is to investigate the association between the quality and quantity of protein and fat consumption with anthropomet... | ['D005260', 'D007492', 'D006801', 'D002648', 'D003430', 'D004041', 'D012574', 'D004044'] |
38,961,252 | eng | Role of ultrasound in predicting telomerase reverse transcriptase (TERT) promoter mutation in follicular thyroid carcinoma. | Telomerase reverse transcriptase (TERT) promoter mutations are associated with tumor aggressiveness. This study aimed to demonstrate the ultrasonographic (US) features of TERT promoter-mutated follicular thyroid cancer (FTC) and evaluate their predictive performance. A total of 63 patients with surgically confirmed FTC... | ['D006801', 'D019098', 'D011401', 'D005260', 'D008297', 'D009154', 'D008875', 'D014463', 'D018263', 'D000328', 'D013964', 'D000368', 'D012189'] |
38,961,245 | eng | Mammalian cell display with automated oligo design and library assembly allows for rapid residue level conformational epitope mapping. | Precise epitope determination of therapeutic antibodies is of great value as it allows for further comprehension of mechanism of action, therapeutic responsiveness prediction, avoidance of unwanted cross reactivity, and vaccine design. The golden standard for discontinuous epitope determination is the laborious X-ray c... | ['D006801', 'D000086402', 'D018604', 'D000939', 'D064370', 'D000086382', 'D019151', 'D000914', 'D000818', 'D057809', 'D061505', 'D015723'] |
38,961,219 | eng | AANAT1 regulates insect midgut detoxification through the ROS/CncC pathway. | Insecticide resistance has been a problem in both the agricultural pests and vectors. Revealing the detoxification mechanisms may help to better manage insect pests. Here, we showed that arylalkylamine N-acetyltransferase 1 (AANAT1) regulates intestinal detoxification process through modulation of reactive oxygen speci... | ['D000818', 'D017382', 'D008658', 'D047068', 'D019476', 'D000330', 'D007306', 'D041981'] |
38,961,200 | eng | Biparatopic anti-PCSK9 antibody enhances the LDL-uptake in HepG2 cells. | Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a promising therapeutic target to reduce lipids. In 2020, we reported a chimeric camelid-human heavy chain antibody VHH-B11-Fc targeting PCSK9. Recently, it was verified that VHH-B11 binds one linear epitope in the PCSK9 hinge region. To enhance its d... | ['D006801', 'D000071449', 'D056945', 'D000091362', 'D020349', 'D011973', 'D000939', 'D008077'] |
38,961,199 | eng | Characterization of the GGP gene family in potato (Solanum tuberosum L.) and Pepper (Capsicum annuum L.) and its expression analysis under hormonal and abiotic stresses. | GDP-L-galactose phosphorylase (GGP) is a key rate-limiting enzyme in plant ascorbic acid synthesis, which plays an important role in plant growth and development as well as stress response. However, the presence of GGP and its function in potato and pepper are not known. In this study, we first identified two GGP genes... | ['D011198', 'D002212', 'D018506', 'D013312', 'D010802', 'D010940', 'D005810', 'D010937', 'D011401'] |
38,961,197 | eng | Integrative proteome and metabolome unveil the central role of IAA alteration in axillary bud development following topping in tobacco. | Axillary bud is an important aspect of plant morphology, contributing to the final tobacco yield. However, the mechanisms of axillary bud development in tobacco remain largely unknown. To investigate this aspect of tobacco biology, the metabolome and proteome of the axillary buds before and after topping were compared.... | ['D007210', 'D014026', 'D020543', 'D055442', 'D010940', 'D018506', 'D005419', 'D035264', 'D010937'] |
38,961,195 | eng | Structure and engineering of Brevibacillus laterosporus Cas9. | The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA targets complementary to an RNA guide, and is widely used as a powerful genome-editing tool. Here, we report the crystal structure of Brevibacillus laterosporus Cas9 (BlCas9, also known as BlatCas9), in complex with a guide RNA and its target DNA at 2.4-Å... | ['D058675', 'D000072669', 'D000076987', 'D000094704', 'D006801', 'D064113', 'D015202'] |
38,961,190 | eng | Analysis of culture and RNA isolation methods for precision-cut liver slices from cirrhotic rats. | Precision-cut liver slices (PCLS) are increasingly used as a model to investigate anti-fibrotic therapies. However, many studies use PCLS from healthy animals treated with pro-fibrotic stimuli in culture, which reflects only the early stages of fibrosis. The effects of different culture conditions on PCLS from cirrhoti... | ['D000818', 'D051381', 'D008099', 'D008103', 'D003907', 'D008297', 'D012313', 'D007328', 'D017207', 'D012643', 'D046509'] |
38,961,189 | eng | NF-κB inhibitor alpha controls SARS-CoV-2 infection in ACE2-overexpressing human airway organoids. | As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model overexpressing the ACE2 receptor (ACE2-OE) that supports robust viral replication ... | ['D006801', 'D009940', 'D000085962', 'D000086402', 'D000086382', 'D014779', 'D000072000', 'D016328'] |
38,961,188 | eng | Dexamethasone treatment influences tendon healing through altered resolution and a direct effect on tendon cells. | Inflammation, corticosteroids, and loading all affect tendon healing, with an interaction between them. However, underlying mechanisms behind the effect of corticosteroids and the interaction with loading remain unclear. The aim of this study was to investigate the role of dexamethasone during tendon healing, including... | ['D003907', 'D000818', 'D051381', 'D014945', 'D013708', 'D000125', 'D000071999', 'D008297', 'D017305', 'D000199', 'D003094', 'D017207', 'D013710', 'D005109', 'D012333', 'D051792'] |
38,961,181 | eng | EDTP enhances and protects the fluorescent signal of GFP in cleared and expanded tissues. | Advanced 3D high-resolution imaging techniques are essential for investigating biological challenges, such as neural circuit analysis and tumor microenvironment in intact tissues. However, the fluorescence signal emitted by endogenous fluorescent proteins in cleared or expanded biological samples gradually diminishes w... | ['D049452', 'D000818', 'D021621', 'D051379', 'D038761', 'D005453'] |
38,961,148 | eng | Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer's disease: a longitudinal study. | Understanding the exact pathophysiological mechanisms underlying the involvement of triggering receptor expressed on myeloid cells 2 (TREM2) related microglia activation is crucial for the development of clinical trials targeting microglia activation at different stages of Alzheimer's disease (AD). Given the contradict... | ['D006801', 'D000544', 'D011971', 'D008562', 'D015415', 'D005260', 'D008297', 'D000368', 'D008137', 'D016875', 'D059906', 'D000369', 'D016229', 'D049268', 'D058225', 'D017628'] |
38,961,143 | eng | Identification of hub genes associated with diabetic cardiomyopathy using integrated bioinformatics analysis. | Diabetic cardiomyopathy (DCM) is a common cardiovascular complication of diabetes, which may threaten the quality of life and shorten life expectancy in the diabetic population. However, the molecular mechanisms underlying the diabetes cardiomyopathy are not fully elucidated. We analyzed two datasets from Gene Expressi... | ['D058065', 'D019295', 'D000818', 'D051379', 'D053263', 'D060066', 'D006801', 'D017395', 'D020869', 'D017526', 'D063990', 'D005786'] |
38,961,131 | eng | PSA doubling time 4.65 months as an optimal cut-off of Japanese nonmetastatic castration-resistant prostate cancer. | A multicenter study of nonmetastatic castration-resistant prostate cancer (nmCRPC) was conducted to identify the optimal cut-off value of prostate-specific antigen (PSA) doubling time (PSADT) that correlated with the prognosis in Japanese nmCRPC. Of the 515 patients diagnosed and treated for nmCRPC at 25 participating ... | ['D006801', 'D008297', 'D017430', 'D064129', 'D000368', 'D008875', 'D007564', 'D011379', 'D000369', 'D000095225'] |
38,961,129 | eng | Undenatured type II collagen protects against collagen-induced arthritis by restoring gut-joint homeostasis and immunity. | Oral administration of harmless antigens can induce suppression of reactive immune responses, a process that capitalises on the ability of the gastrointestinal tract to tolerate exposure to food and commensal microbiome without triggering inflammatory responses. Repeating exposure to type II collagen induces oral toler... | ['D000818', 'D001169', 'D024043', 'D051379', 'D000069196', 'D006706', 'D008297', 'D007596', 'D008811', 'D020381', 'D000097043', 'D000284'] |
38,961,127 | eng | Deriving general structure-activity/selectivity relationship patterns for different subfamilies of cyclin-dependent kinase inhibitors using machine learning methods. | Cyclin-dependent kinases (CDKs) play essential roles in regulating the cell cycle and are among the most critical targets for cancer therapy and drug discovery. The primary objective of this research is to derive general structure-activity relationship (SAR) patterns for modeling the selectivity and activity levels of ... | ['D047428', 'D000069550', 'D013329', 'D018844', 'D006801', 'D016571', 'D055808'] |
38,961,108 | eng | KAT8-mediated H4K16ac is essential for sustaining trophoblast self-renewal and proliferation via regulating CDX2. | Abnormal trophoblast self-renewal and differentiation during early gestation is the major cause of miscarriage, yet the underlying regulatory mechanisms remain elusive. Here, we show that trophoblast specific deletion of Kat8, a MYST family histone acetyltransferase, leads to extraembryonic ectoderm abnormalities and e... | ['D014327', 'D000071616', 'D000818', 'D005260', 'D006801', 'D049109', 'D051379', 'D011247', 'D000066673', 'D051548', 'D000026', 'D018345', 'D006657', 'D002454', 'D010929'] |
38,961,106 | eng | Bergenin inhibits growth of human cervical cancer cells by decreasing Galectin-3 and MMP-9 expression. | Cervical cancer is still the leading cause of cancer mortality worldwide even after introduction of vaccine against Human papillomavirus (HPV), due to low vaccine coverage, especially in the developing world. Cervical cancer is primarily treated by Chemo/Radiotherapy, depending on the disease stage, with Carboplatin/Ci... | ['D006801', 'D020780', 'D001578', 'D005260', 'D002583', 'D037502', 'D049109', 'D045744', 'D062105', 'D037161', 'D015972', 'D017209', 'D006367', 'D001798'] |
38,961,103 | eng | An evaluation of inflammatory and endothelial dysfunction markers as determinants of peripheral arterial disease in those with diabetes mellitus. | The most serious long-term effects of diabetes is peripheral artery disease (PAD) which increases the chance of developing diabetic foot ulcers, gangrene and even lower limb amputation. The clinical manifestations of PAD which are typically not revealed until symptoms like intermittent claudication, rest pain and ische... | ['D006801', 'D015415', 'D058729', 'D008297', 'D005260', 'D003924', 'D008875', 'D019010', 'D000368', 'D007249', 'D015850', 'D018799', 'D016209', 'D004730', 'D016022'] |
38,961,101 | eng | NLRC5 promotes tumorigenesis by regulating the PI3K/AKT signaling pathway in cervical cancer. | Cervical cancer (CC) is the fourth most common cancer among women worldwide. NLR Family CARD Domain Containing 5 (NLRC5) plays an important role in tumorigenesis. However, its effect and mechanism in CC remains unclear. In this study, we aimed to investigate the function of NLRC5 in CC. NLRC5 was found to be down-regul... | ['D006801', 'D005260', 'D002583', 'D051057', 'D015398', 'D019869', 'D047908', 'D008875', 'D049109', 'D045744', 'D011379', 'D063646', 'D015972', 'D002465', 'D000328'] |
38,961,086 | eng | Generation of functional neurons from adult human mucosal olfactory ensheathing glia by direct lineage conversion. | A recent approach to promote central nervous system (CNS) regeneration after injury or disease is direct conversion of somatic cells to neurons. This is achieved by transduction of viral vectors that express neurogenic transcription factors. In this work we propose adult human mucosal olfactory ensheathing glia (hmOEG)... | ['D006801', 'D000818', 'D009457', 'D009474', 'D051379', 'D000328', 'D009831', 'D051792', 'D019070', 'D006624', 'D009830', 'D002478'] |
38,961,085 | eng | Flotillin-mediated stabilization of unfolded proteins in bacterial membrane microdomains. | The function of many bacterial processes depends on the formation of functional membrane microdomains (FMMs), which resemble the lipid rafts of eukaryotic cells. However, the mechanism and the biological function of these membrane microdomains remain unclear. Here, we show that FMMs in the pathogen methicillin-resistan... | ['D008565', 'D021962', 'D055624', 'D001426', 'D058767', 'D000255', 'D046915', 'D006801', 'D055550', 'D013203', 'D000818', 'D051379'] |
38,961,079 | eng | A mitochondrial checkpoint to NF-κB signaling. | Mitochondrial dysfunction can elicit multiple inflammatory pathways, especially when apoptotic caspases are inhibited. Such an inflammatory program is negatively regulated by the autophagic disposal of permeabilized mitochondria. Recent data demonstrate that the ubiquitination of mitochondrial proteins is essential for... | ['D016328', 'D015398', 'D006801', 'D008928', 'D000818', 'D054875', 'D017209', 'D024101', 'D001343', 'D051550'] |
38,961,076 | eng | Multi-omic characterization of allele-specific regulatory variation in hybrid pigs. | Hybrid mapping is a powerful approach to efficiently identify and characterize genes regulated through mechanisms in cis. In this study, using reciprocal crosses of the phenotypically divergent Duroc and Lulai pig breeds, we perform a comprehensive multi-omic characterization of regulatory variation across the brain, l... | ['D000818', 'D019175', 'D000483', 'D013552', 'D005260', 'D002843', 'D009928', 'D008099', 'D010920', 'D008297', 'D001921', 'D034421', 'D000073336', 'D011247', 'D000095028'] |
38,961,073 | eng | Barbed arrow-like structure membrane with ultra-high rectification coefficient enables ultra-fast, highly-sensitive lateral-flow assay of cTnI. | Acute myocardial infarction (AMI) has become a public health disease threatening public life safety due to its high mortality. The lateral-flow assay (LFA) of a typical cardiac biomarker, troponin I (cTnI), is essential for the timely warnings of AMI. However, it is a challenge to achieve an ultra-fast and highly-sensi... | ['D019210', 'D006801', 'D009203', 'D008567', 'D057230', 'D015415', 'D012680'] |
38,961,067 | eng | A(H2N2) and A(H3N2) influenza pandemics elicited durable cross-reactive and protective antibodies against avian N2 neuraminidases. | Human cases of avian influenza virus (AIV) infections are associated with an age-specific disease burden. As the influenza virus N2 neuraminidase (NA) gene was introduced from avian sources during the 1957 pandemic, we investigate the reactivity of N2 antibodies against A(H9N2) AIVs. Serosurvey of healthy individuals r... | ['D009439', 'D000818', 'D006801', 'D000914', 'D053122', 'D005260', 'D003429', 'D051379', 'D007251', 'D000368', 'D058873', 'D053121', 'D008297', 'D009976', 'D001717', 'D008875', 'D005585', 'D053127', 'D000328', 'D014764'] |
38,961,064 | eng | O-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer. | Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhibitors (CDK4/6i), such as palbociclib, remains a substantial challenge in clinical settings. Using high-through... | ['D006801', 'D051358', 'D001943', 'D051361', 'D051739', 'D005260', 'D019008', 'D010879', 'D011725', 'D045744', 'D017351', 'D000818', 'D051379', 'D047428', 'D023041'] |
38,961,063 | eng | Three SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective. | As the new SARS-CoV-2 Omicron variants and subvariants emerge, there is an urgency to develop intranasal, broadly protective vaccines. Here, we developed highly efficacious, intranasal trivalent SARS-CoV-2 vaccine candidates (TVC) based on three components of the MMR vaccine: measles virus (MeV), mumps virus (MuV) Jery... | ['D000818', 'D064370', 'D000281', 'D005260', 'D000086402', 'D000086382', 'D000914', 'D057134', 'D051379', 'D000086663', 'D006224', 'D006801', 'D022542', 'D008459', 'D007074', 'D009109', 'D018345', 'D008647', 'D007070'] |
38,961,057 | eng | Gestational valproic acid exposure enhances facial stimulation-evoked cerebellar mossy fiber-granule cell transmission via GluN2A subunit-containing NMDA receptor in offspring mice. | Valproic acid (VPA) is one of the most effective antiepileptic drugs, and exposing animals to VPA during gestation has been used as a model for autism spectrum disorder (ASD). Numerous studies have shown that impaired synaptic transmission in the cerebellar cortical circuits is one of the reasons for the social deficit... | ['D000818', 'D016194', 'D014635', 'D011247', 'D005260', 'D051379', 'D011297', 'D009435', 'D000067877', 'D004195', 'D008297', 'D002531', 'D000927'] |
38,961,055 | eng | Recreating the biological steps of viral infection on a cell-free bioelectronic platform to profile viral variants of concern. | Viral mutations frequently outpace technologies used to detect harmful variants. Given the continual emergence of SARS-CoV-2 variants, platforms that can identify the presence of a virus and its propensity for infection are needed. Our electronic biomembrane sensing platform recreates distinct SARS-CoV-2 host cell entr... | ['D000086402', 'D006801', 'D053586', 'D064370', 'D000086382', 'D008561', 'D002474', 'D009154', 'D053585'] |
38,961,054 | eng | DCAF15 control of cohesin dynamics sustains acute myeloid leukemia. | The CRL4-DCAF15 E3 ubiquitin ligase complex is targeted by the aryl-sulfonamide molecular glues, leading to neo-substrate recruitment, ubiquitination, and proteasomal degradation. However, the physiological function of DCAF15 remains unknown. Using a domain-focused genetic screening approach, we reveal DCAF15 as an acu... | ['D002868', 'D006801', 'D000097722', 'D018797', 'D015470', 'D045744', 'D004249', 'D004261', 'D000107', 'D000818', 'D009687', 'D051379', 'D002843', 'D044767', 'D017209', 'D049109', 'D057809'] |
38,961,053 | eng | Venetoclax resistance in acute lymphoblastic leukemia is characterized by increased mitochondrial activity and can be overcome by co-targeting oxidative phosphorylation. | Deregulated apoptosis signaling is characteristic for many cancers and contributes to leukemogenesis and treatment failure in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Apoptosis is controlled by different pro- and anti-apoptotic molecules. Inhibition of anti-apoptotic molecules like B-cell lymphoma 2 (BC... | ['D019086', 'D006801', 'D010085', 'D008928', 'D019008', 'D013449', 'D054198', 'D000818', 'D045744', 'D051379', 'D017209', 'D000970', 'D023041', 'D019253'] |
38,960,996 | eng | Identification of candidate gene associated with maize northern leaf blight resistance in a multi-parent population. | QTL mapping combined with genome-wide association studies, revealed a potential candidate gene for resistance to northern leaf blight in the tropical CATETO-related maize line YML226, providing a basis for marker-assisted selection of maize varieties Northern leaf blight (NLB) is a foliar disease that can cause severe... | ['D003313', 'D060467', 'D010935', 'D040641', 'D020641', 'D055106', 'D002874', 'D017343', 'D010641', 'D018515', 'D010940'] |
38,960,994 | eng | BIG coordinates auxin and SHORT ROOT to promote asymmetric stem cell divisions in Arabidopsis roots. | BIG regulates ground tissue formative divisions by bridging the auxin gradient with SHR abundance in Arabidopsis roots. The formative divisions of cortex/endodermis initials (CEIs) and CEI daughter cells (CEIDs) in Arabidopsis roots are coordinately controlled by the longitudinal auxin gradient and the radial SHORT ROO... | ['D017360', 'D007210', 'D029681', 'D018517', 'D018506', 'D060049', 'D009154', 'D013234', 'D016213', 'D002148', 'D014157'] |
38,960,949 | eng | A "Prime and Expand" strategy using the multifunctional fusion proteins to generate memory-like NK cells for cell therapy. | Adoptive cellular therapy (ACT) using memory-like (ML) natural killer (NK) cells, generated through overnight ex vivo activation with IL-12, IL-15, and IL-18, has shown promise for treating hematologic malignancies. We recently reported that a multifunctional fusion molecule, HCW9201, comprising IL-12, IL-15, and IL-18... | ['D007694', 'D006801', 'D000818', 'D011993', 'D051379', 'D007156', 'D064987', 'D016219', 'D019409'] |
38,960,936 | eng | Shaping Drosophila eggs: unveiling the roles of Arpc1 and cpb in morphogenesis. | The Drosophila egg chamber (EC) starts as a spherical tissue at the beginning. With maturation, the outer follicle cells of EC collectively migrate in a direction perpendicular to the anterior-posterior axis, to shape EC from spherical to ellipsoidal. Filamentous actin (F-actin) plays a significant role in shaping indi... | ['D000818', 'D029721', 'D000199', 'D005260', 'D009024', 'D004331', 'D008840', 'D051376', 'D051344', 'D010063'] |
38,960,916 | eng | PEGylation renders carnosine resistant to hydrolysis by serum carnosinase and increases renal carnosine levels. | Carnosine's protective effect in rodent models of glycoxidative stress have provided a rational for translation of these findings in therapeutic concepts in patient with diabetic kidney disease. In contrast to rodents however, carnosine is rapidly degraded by the carnosinase-1 enzyme. To overcome this hurdle, we sought... | ['D002336', 'D000818', 'D011092', 'D006868', 'D004150', 'D051379', 'D006801', 'D007668', 'D008297'] |
38,960,899 | eng | Impact of antiphospholipid antibodies on cardiac valve lesions in systemic lupus erythematosus: a systematic review and meta-analysis. | This meta-analysis assesses antiphospholipid antibodies' (aPLs) impact on heart valve disease in Systemic Lupus Erythematosus (SLE) patients. We searched PubMed, Embase, Cochrane, and Web of Science up to January 2024 for comparative studies of heart valve disease in aPL-positive versus aPL-negative SLE patients. Fixed... | ['D006801', 'D008180', 'D017152', 'D006349', 'D017153', 'D016682', 'D006351', 'D005260'] |
38,960,889 | eng | Galectin-1 Promotes Gastric Carcinoma Progression and Cisplatin Resistance Through the NRP-1/c-JUN/Wee1 Pathway. | Gastric cancer (GC) is among the deadliest malignancies and the third leading cause of cancer-related deaths worldwide. Galectin-1 (Gal-1) is a primary protein secreted by cancer-associated fibroblasts (CAFs); however, its role and mechanisms of action of Gal-1 in GC remain unclear. In this study, we stimulated GC cell... | ['D013274', 'D006801', 'D037483', 'D002945', 'D019008', 'D039942', 'D049109', 'D008297', 'D005260', 'D018450', 'D045744', 'D000970', 'D015398', 'D008875', 'D051379', 'D000818', 'D002465', 'D000072645'] |
38,960,704 | eng | Polycomb repressive complex 2 is critical for mouse cortical glutamatergic neuron development. | The Polycomb Repressive Complex 2 (PRC2) regulates corticogenesis, yet the consequences of mutations to this epigenetic modifier in the mature brain are poorly defined. Importantly, PRC2 core genes are haploinsufficient and causative of several human neurodevelopmental disorders. To address the role of PRC2 in mature c... | ['D000818', 'D063151', 'D009474', 'D051379', 'D055495', 'D018698', 'D002540', 'D008297', 'D008810', 'D005260', 'D008822'] |
38,959,503 | eng | Immune-Targeted Therapies for Depression: Current Evidence for Antidepressant Effects of Monoclonal Antibodies. | Importance: Increasing evidence suggests a potential role of immune-modulatory drugs for treatment-resistant depression. This scoping review explores the emerging evidence regarding the antidepressant effects of monoclonal antibodies (mAbs), a relatively newer class of immune therapeutics with favorable safety profile.... | ['D006801', 'D000911', 'D000928', 'D061218'] |
38,959,481 | eng | Normalization of C1 Inhibitor in a Patient with Hereditary Angioedema. | Hereditary angioedema is a potentially life-threatening autosomal dominant condition, causing attacks of angioedema due to failure to regulate bradykinin. Nearly all cases of hereditary angioedema are caused by mutations in the gene encoding C1 inhibitor, SERPING1. C1 inhibitor is a multifunctional protein produced in ... | ['D006801', 'D050718', 'D054179', 'D016031', 'D007223', 'D008297', 'D005260'] |
38,961,171 | eng | Evaluation of EMLA cream with microneedle patches in palatal anesthesia in children: a randomized controlled clinical trial. | Palatal injections are considered to be one of the most painful dental procedures. As a result, it was important to find alternatives to this painful injection to improve children's cooperation. The dental literature mentioned using EMLA cream as a possible alternative to conventional injections, but its anesthetic eff... | ['D006801', 'D002648', 'D000077442', 'D005260', 'D008297', 'D000779', 'D010159', 'D009339', 'D010147', 'D000766', 'D008012'] |
38,958,292 | eng | Subdural Spread of Local Anesthetic Mimicking Cerebrovascular Accident: A Case Report of Horner's Syndrome, Upper Limb Paresthesia, and Motor Weakness After Thoracic Epidural Analgesia. | A 53-year-old woman underwent a thoracic epidural placement for a scheduled laparotomy. Postoperatively the patient had no appreciable epidural level after multiple epidural boluses and was noted to be severely hypotensive with right upper extremity weakness and numbness. She subsequently developed right-sided Horner's... | ['D006801', 'D005260', 'D008875', 'D006732', 'D015360', 'D020521', 'D010292', 'D018908', 'D000779', 'D034941', 'D003937'] |
38,957,912 | eng | Comparative evaluation of intranasal dexmedetomidine, intranasal midazolam, and nitrous oxide for conscious sedation of anxious children undergoing dental treatment: A randomized cross-over trial. | Pharmacological methods, specifically sedatives, have gained popularity in managing the behavior of children during dental appointments. | ['D006801', 'D009609', 'D008874', 'D002648', 'D000281', 'D018592', 'D006993', 'D020927', 'D016292', 'D008297', 'D005260', 'D016854', 'D000766', 'D018685', 'D019140', 'D002652', 'D011670'] |
38,957,911 | eng | Inferior alveolar nerve block anesthesia in children: The effect of ibuprofen and phentolamine mesylate on pain perception. | For successfully managing pediatric dental patients, local anesthesia is essential to eliminate pain during or after the operative period. An early recovery from soft-tissue anesthesia after an inferior alveolar nerve block (IANB) should benefit a young child patient by avoiding the risk of inadvertently biting the sof... | ['D006801', 'D010646', 'D002648', 'D007052', 'D009407', 'D000766', 'D005260', 'D008297', 'D008340', 'D000779', 'D058748', 'D010149', 'D011672', 'D008012', 'D018712', 'D010147'] |
38,957,910 | eng | A comparative evaluation of the efficiency of warm local anesthetic solution delivered on precooled injection sites with the conventional local anesthetic technique in 7-9-year-old children: A randomized split-mouth cross-over trial. | Both precooling the site and injecting a warm anesthetic solution have proven to be efficient in reducing pain individually. However, there is insufficient data on evaluating the efficiency of precooling the site of injection along with the simultaneous administration of a warm local anesthetic solution on the same sit... | ['D006801', 'D002648', 'D000779', 'D004311', 'D000766', 'D005260', 'D008297', 'D008012', 'D018592', 'D000772', 'D007267', 'D009407', 'D010147', 'D006358', 'D058748', 'D008340'] |
38,956,697 | eng | Effect of norepinephrine and phenylephrine on prothrombotic response in patients undergoing cesarean section under spinal anesthesia: protocol for a randomized, double-blind, controlled study. | Norepinephrine and phenylephrine are commonly used vasoactive drugs to treat hypotension during the perioperative period. The increased release of endogenous norepinephrine elicits prothrombotic changes, while parturients are generally in a hypercoagulable state. Therefore, this trial aims to investigate whether there ... | ['D006801', 'D002585', 'D000775', 'D005260', 'D009638', 'D004311', 'D011247', 'D010656', 'D014662', 'D016032', 'D000773', 'D000328', 'D005338', 'D005169', 'D016896', 'D001777', 'D006439'] |
38,956,694 | eng | Establishment and validation of a predictive nomogram for polyuria during general anesthesia in thoracic surgery. | To develop and evaluate a predictive nomogram for polyuria during general anesthesia in thoracic surgery. | ['D006801', 'D049451', 'D005260', 'D008297', 'D012189', 'D000768', 'D008875', 'D011141', 'D019616', 'D000368', 'D012372', 'D000328'] |
38,956,681 | eng | Effects of ultrasound-guided serratus plane block combined with general anesthesia on postoperative early quality of recovery and analgesia in patients undergoing transapical transcatheter aortic valve implantation surgery: study protocol for a randomized controlled trial. | Compared to traditional thoracotomy, transapical transcatheter aortic valve implantation (TAVI) surgery offers reduced trauma and faster recovery, fostering the adoption of enhanced recovery after surgery (ERAS) protocols in cardiac surgery. Despite these advancements, postoperative pain management has received insuffi... | ['D006801', 'D000768', 'D010149', 'D009407', 'D065467', 'D011446', 'D018084', 'D016032', 'D016896', 'D016058', 'D020127', 'D008297', 'D005260', 'D013997', 'D010147', 'D000368', 'D002681', 'D059408'] |
38,956,630 | eng | Biofeedback combined with percutaneous electrical pudendal nerve stimulation for the treatment of low anterior rectal resection syndrome: a study protocol for a randomized controlled trial. | Low anterior resection syndrome (LARS) is a distressing condition that affects approximately 25-80% of patients following surgery for rectal cancer. LARS is characterized by debilitating bowel dysfunction symptoms, including fecal incontinence, urgent bowel movements, and increased frequency of bowel movements. Althoug... | ['D006801', 'D001676', 'D060525', 'D016032', 'D016896', 'D004561', 'D011788', 'D005242', 'D012004', 'D005260', 'D015337', 'D008875', 'D013577', 'D008297', 'D000328', 'D017773', 'D020127', 'D002681', 'D003672', 'D000368', 'D000078542', 'D011183', 'D004576', 'D008365'] |
38,956,473 | eng | Comparison of analgesic effectiveness between nefopam and propacetamol in living kidney donors following rectus sheath block after hand-assisted living donor nephrectomy: a prospective, randomized controlled trial. | Nefopam and propacetamol are the most commonly used analgesics in postoperative multimodal analgesic regimens. Distinct mechanisms are involved in each drug's anti-nociceptive effects. No studies have compared pain relief efficacy between the two drugs in patients undergoing transplantation surgery. Here, we investigat... | ['D006801', 'D009340', 'D009392', 'D008297', 'D005260', 'D011446', 'D019520', 'D010149', 'D000082', 'D009407', 'D000328', 'D018712', 'D008875', 'D000701', 'D016058', 'D017568'] |
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PubMed articles with MeSH terms
Small dataset of article abstacts and titles with MeSH terms information.
Articles are selected with search for 100 top articles for level 1 MeSH terms. The articles with empty abstract are discarded.
Dataset columns:
- pubmedid - pubmed id of the article
- language - 3 character language code
- title - article title
- abstract - article abstract
- termIds - serialized list of MeSH term ids of the article
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