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1. A comparative study was conducted on the molecular weights of glutathione S-transferases in the housefly and liver of the mouse and rat using Sephadex G-100 gel chromatography. 2. The values varied depending upon the buffers used in gel filtration. Molecular weights of 44,600, 53,600 and 43,000 daltons respectively ... | US |
1. Vitellogenin has been purified from mature eggs and the hemolymph of adult females of Manduca sexta by a combination of gel permeation chromatography and sodium bromide density gradient centrifugation. 2. It has a molecular weight of 2.6 x 10(5) and is a glycolipoprotein containing approx 11% lipids and 3% carbohydr... | US |
1. A major locus with two alleles is responsible for large differences in erythrocyte 2,3-diphosphoglycerate (DPG) levels in Rattus norvegicus. Blood from homozygous High-DPG, homozygous Low-DPG and heterozygous animals was used to measure blood indices and red cell enzyme activities. 2. Significant differences between... | US |
1. Superoxide dismutase (superoxide: superoxide oxido-reductase, E.C. 1.15.1.1) in different species was determined quantitatively and qualitatively. Although quantitative differences were minor, there were significant differences in the isoenzyme patterns among the species. 2. No quantitative differences were found in... | US |
1. The occurrence and distribution of twelve dehydrogenases have been studied histochemically in two species of rhabdocoel turbellarians entosymbiotic in marine bivalves. 2. Both species (Paravortex scrobiculariae in Scrobicularia plana and P. cardii in Cerastoderma edule) possess dehydrogenases concerned with the thre... | US |
1. Isolated canine haptoglobin behaved identically to the alpha 2 beta 2 structure typical of human haptoglobin type 1-1 on alkaline polyacrylamide gel electrophoresis and on gel filtration. 2. In the presence of urea or sodium dodecyl sulphate canine haptoglobin dissociated into alpha beta subunits that separated into... | US |
1. Uropygial glands of domestic goose and mallard which synthesize methyl-branched fatty acids, contain large quantities of cytosolic malonyl-CoA decarboxylase and a small quantity of mitochondrial enzyme. 2. Uropygial glands of chicken and the liver of geese which generate little methyl-branched acids, contain only sm... | US |
1. The plasma membrane of the dogfish erythrocyte is characterized. 2. Surface membranes were isolated from dogfish red cells. 3. Cells suspended in a hypotonic zinc chloride buffer (0.5 mM ZnCl2, 5 mM Tris-HCl, pH 8.0) tended to enucleate spontaneously. 4. By gentle homogenization relatively high yields of red cell "g... | US |
1. Amino acid sequences of the soluble tryptic peptides of yellowfin tuna myoglobin, comprising 60% of the total residues, are presented. 2. The amino terminus is acetylated as shown by Fourier transform nuclear magnetic resonance spectroscopy of an N-terminal dipeptide. 3. Comparison of peptide sequences from yellowfi... | US |
1. A study has been made of the gelatins obtained by treating a number of fresh and fossil collagens with dilute formic acid. 2. Compositions of their peptides separated by filtration through polyacrylamide gels has been established. 3. Solubilization results in the freeing of much aspartic acid and less glycine, the a... | US |
Patterns of mortality in 11 air-conditioned and 9 un-air-conditioned nursing homes in New York City have been investigated to determine the impacts of heat waves on nursing home occupants and the efficacy of air conditioning in reducing these impacts. During each of four heat waves in 1972 and 1973, the number of death... | US |
The effect of dietary vitamin A and NO2 exposure on the hamster lung was evaluated by histopathology, electron microscopy, and thymidine uptake studies. Hamsters were maintained on deficient (0 micrograms), adequate (100 micrograms), and high (200 micrograms) dose levels of vitamin A while being exposed repeatedly to 1... | US |
An animal model for asymptomatic and overt lead toxicity is presented in which rabbit pups, 1 to 30 days of age, were fed a milk supplement containing Pb(NO3)2. Reduced body growth, increased mortality, hematologic abnormalities, kidney and liver histopathology, as well as encephalopathy, were observed in rabbits 2 to ... | US |
The tooth lead level of 30 lead-exposed children was measured in situ using an X-ray fluorescence technique. The tooth lead concentration divided by the child's age correlated with the free erythroporphyrin (FEP) (r = 0.51) and the blood lead levels (r = 0.31). The mean tooth lead concentrations of 10 Class IV children... | US |
Recent investigation into a possible association between exposure to Leptophos and neurological symptoms in insecticide factory workers makes study of the neurological effects of Leptophos in the experimental situation particularly important. The present study utilizes a single oral dose of 200 mg/kg of Leptophos in 20... | US |
Lead nitrate was administered intravenously at 50 mg/kg to five inbred strains (MHA, LSH, LHC, CB, and P)4) and the non-inbred LVG strain of pregnant hamsters early on the 8th gestation day. All fetuses from treated and control hamsters were collected on the 15th gestation day and examined for the frequency and kinds o... | US |
Quantitative birefringent particle counts per 10 high-power fields in lung tissue were correlated with age, sex, and occupational exposure in 37 cases of pulmonary alveolar proteinosis. Counts were significantly higher in pulmonary alveolar proteinosis cases in both regions of alveolar proteinosis (47 +/- 11) and periv... | US |
Resting and stimulated fluxes of sodium and potassium across the giant axon of the marine annelid, Myxicola infundibulum, have been characterized using the technique of internal dialysis. In most respects the ion movements were found to be similar to those in squid axons. Sodium efflux and potassium influx were found t... | US |
Air-water interface films of purified cattle rhodopsin and defined phospholipids are formed by the osmotic lysis of reconstituted membrane vesicles. The interface films thus formed consist of a phospholipid monolayer containing vesicle membrane fragments. Rhodopsin molecules at the interface are restricted within the m... | US |
C57B16 mice were immunized with either live, attenuated TC-83 strain VEE virus vaccine or formalin-inactivated VEE vaccine combined with Bordetella pertussis. The kinetics of specific donor and adoptively-immunized recipient anti-VEE neutralizing antibody responses were studied. Donor mice immunized with either live or... | US |
1. Hexokinase III was partially purified from the liver of the American bullfrong, Rana catesbeiana, using DEAE-cellulose column chromatography. 2. It was inhibited by glucose concentrations above 5 x 10(-5) M (pH 5.9), 10(-4) M (pH 6.7) or 10(-3) M (pH 7.5). 3. There was virtually no inhibition by excess glucose at pH... | US |
1. Leopard frog (Rana pipiens) erythrocytes are agglutinated by the plant lectins concanavalin A and phytohemagglutinin. 2. Concanavalin A hemagglutination can be specifically inhibited by the sugars mannose, glucose, arabohexulose, alpha-methyl-D-mannopyranoside, N-acetyl-D-glucosamine, maltose, sucrose, trehalose and... | US |
After human skin is treated with 2 N sodium thiocyanate, epidermis is easily separated from dermis. The level of cleavage occurs at the lamina lucida of the basement membrane zone. Bullous pemphigoid antigen remains attached to the epidermis. | US |
In the yeast Saccharomyces cerevisiae we have carried out a detailed study of the response of transcription to the inhibition of translation. Measurement of the incorporation of labeled bases and nucleosides into the nucleoside triphosphate pools revealed that amino acid deprivation brings about a 10- to 50-fold inhibi... | US |
A 16-year-old girl with advanced cirrhosis and severe alpha 1-antitrypsin deficiency of the homozygous Pi ZZ phenotype was treated by orthotopic liver transplantation. After replacement of the liver with a homograft from a donor with the normal Pi MM phenotype, the alpha 1-antitrypsin concentration in the recipient's s... | US |
Some of the spontaneous streptomycin-resistant mutants of Escherichia coli strain C600 exhibit pleiotropic effects in addition to the antibiotic resistance. These effects include decreased growth rates, reduced levels of certain enzymes, and poor support of bacteriophage growth. One of these mutants, strain SM3, was st... | US |
The theoretical relations between replication, initiation, termination, and deoxyribonucleic acid (DNA) accumulation were derived for experiments in which the length of the time required for the replication of the bacterial chromosome (C period) can be varied. This theory enables one to determine absolute values of the... | US |
The electron microscopic changes in genetic and acquired disorders of granulocytes have been reviewed. In rare situations, such as the Chédiak-Higashi syndrome, there are bizarre giant lysosomes. In other conditions associated with abnormal phagocytic function, such as chronic granulomatous disease, there are no qualit... | US |
Trends in renal transplantation stem from recognition of the virtues and drawbacks of this kind of treatment and from a better appreciation of the interrelationship between transplantation and dialysis. | US |
The time course of washout of tracer from the myocardium provides an estimate of the flow per unit volume when the blood-tissue exchange is flow-limited. Methods of testing for the flow-limitation and for the absence of influences of low permeability or diffusion on the washout include the uses of paired or multiple tr... | US |
Kidneys were transplanted in mongrel dogs so that renal venous drainage was into the portal system of the hosts. Thirty-one recipients were not treated, 11 were given one dose of 3 mg of azathioprine per kg, and 11 were given 2 mg of azathioprine per day. Survival was not statistically increased compared with that in t... | US |
Forty-one dog livers were preserved with cold, lactated Ringer's, plasma, or intracellular (Collins) solutions. Consistent survival was obtained with all three solutions for 9 hr. After 18 hr, the plasma and Collins solutions permitted survival, with the Collins solution having a slight overall advantage. The method us... | US |
A set of partially overlapping DNA restriction fragments that support promoter-dependent transcription of the tRNATyr1 gene of Escherichia coli has been used to study site-specific termination in vitro. Transcription termination occurs at a specific site 224-226 nucleotides beyond the end of the structural gene and is ... | US |
Paired immunofluorescent staining with antibodies specific for the major isotypes of mouse immunoglobulin was used to study the ontogenetic expression of diversity of cell surface immunoglobulin. The first B lymphocytes to emerge, derived from cytoplasmic IgM+ precursors, express sIgM exclusively. Between birth and 3 d... | US |
Motile, but generally nonchemotactic (che) mutants of Escherichia coli were examined for complementation and recombination with specialized lambdafla transducing phages. The complex complementation behavior of these mutants found previously in F-prime tests could largely be accounted for by intragenic complementation a... | US |
Fractions of IgG from sera of patients with pemphigoid and pemphigus added to monolayer cultures of mouse epidermal cells resulted in a sparse distribution of cells. Direct immunofluorescence studies of these monolayers revealed epidermal cell surface antigens reacting with pemphigoid and pemphigus antibodies. We sugge... | US |
The transmembrane chemical gradient for Na+ that most living cells maintain represents an energy source which is not sufficient to account for observed cellular sugar or amino acid gradients. This short review summarizes the literature pointing to the above conclusion, and described experimental evidence from a variety... | US |
A patient suffering from chronic active hepatitis with macronodular cirrhosis, positive for hepatitis B surface antigen (HBsAg), was treated with an orthotopic liver allograft. The HBs antigenemia, as measured with several precipitation tests and by complement fixation, became negative after transplantation and remaine... | US |
The ability of E. coli to adapt to constant levels of attractant and repellent chemicals was studied by examining the patterns of flagellar movement in cells subjected to abrupt concentration changes. Wild-type bacteria exhibited transient responses to such stimuli, in support of previous findings. Nonchemotactic mutan... | US |
Juvenile dermatitis herpetiformis occurred in a 20-month-old girl. She had granular lgA, C3, and fibrin bound to the basement membrane zone of the skin by direct immunofluorescence and negative serum antibodies against the skin on indirect immunofluorescence. The HLA typing of peripheral lymphocytes was A1, Aw30, B8, B... | US |
Liver transplantation in humans was first attempted more than 15 yr ago. The 1-yr survival has slowly improved until it has now reached about 50%. In our experience, 46 patients have lived for at least 1 yr, with the longest survival being 9 yr. The high acute mortality in early trials was due in many cases to technica... | US |
This assessment of the role of liver transplantation in treating end-stage liver disease today is based on two major series, one from Denver and the other from the Cambridge/Kings College Hospital, England. The findings of these groups are highlighted, as are the changes in technique that have led to considerably impro... | US |
Between March 1963 and January 1978, 74 patients 18 years of age or younger have had liver replacements at the University of Colorado Medical Center, Denver. The most common cause of native liver failure was biliary atresis (48/74, 65%); the second most common cause was chronic aggressive hepatitis (12/74, 16%). Twenty... | US |
The quality of life after liver transplantation ranges from poor to superior. The social and vocational outcome is dependent on the quality of homograft function and on the steroid doses necessary to maintain function. A good long-term prognosis is usually evident by 1 year postoperatively. The complete rehabilitation ... | US |
In this series of 150 orthotopic hepatic transplants, clinically significant gastrointestinal hemorrhage occurred in 34 patients (23%). Five patients (15%) survived this complication. Enteric perforations occurred in 20 patients following 198 biliary-enteric procedures. Only one patient survived. Enteric perforations u... | US |
During a 16-month period when 93 renal transplants were performed, eight kidney graft ruptures were detected within 18 days of transplantation, without evidence of venous obstruction. Six grafts were removed at the time of an exploratory operation for rupture and only one showed signs of probable irreversible rejection... | US |
The structure and organization of the gene clusters coding for the two tyrosine-accepting tRNA species (tRNA1Tyr and tRNA2Tyr) on the E. coli chromosome have been determined. The mature structural sequences of the two tRNATyr genes, located on opposite sides of the E. coli chromosome, differ by only 2 bp, but sequences... | US |
Twenty-seven consecutive recipients of cadaveric kidneys, including five with pre-existing warm cytotoxic antibodies, were treated with thoracic duct drainage before and after transplantation. Fourteen patients who had lymph drainage for 26 to 58 days before transplantation had minor cytotoxic antibody responses after ... | US |
This paper reviews some of the major evidence and arguments currently available to support the view that human speech perception may require the use of specialized neural mechanisms for perceptual analysis. Experiments using synthetically produced speech signals with adults are briefly summarized and extensions of thes... | US |
Female Swiss Webster mice were immunized intraperitoneally with mouse epididymal spermatozoa or with phosphate buffered saline (PBS) and their fertility was compared by (1) incidence and size of litters, (2) number of uterine implantation sites, and (3) incidence and number of fertilized eggs in the oviducts. Statistic... | US |
Analysis of pulmonary structure-function relationships by microscopy requires that the lung be fixed under carefully controlled physiological conditions, since lung structure is extremely responsive to the relationship between airway and vascular pressures. Unfortunately, standard post-mortem fixation techniques leave ... | US |
The accuracy of absolute quantitation within thick, mineralized tissue specimens is influenced by count rate variations of characteristic X-rays during electron microprobe analysis. The variations occur for electron doses approximately greater than 10(-10) C/micrometer2 and are primarily dependent upon the light elemen... | US |
An acidic proteolytic enzyme which digests host haemoglobin can be isolated and purified from schistosomes. This small glycoprotein is an allergen which sensitizes the host, as shown by immediate hypersensitivity reactions. These are specific for either Schistosoma haematobium or S. mansoni and can be demonstrated by m... | US |
Seventy-five spina bifida infants were studied for results of selectin for treatment. The 31 nonoperated infants had a survival rate of 70% at 18 months, a figure higher than anticipated. Practical difficulties in adhering to the selectin protocol and controlling medical management in a large North American city were n... | US |
In this report the ability of nuclei to carry out mixed function oxidase activity has been discussed. The properties of the nuclear system have been contrasted with those of microsomes and the localization of the nuclear mixed function oxidase has been definitively established. In addition, the nuclei have been shown t... | US |
Cylindrical polyacrylamide gels were automatically analyzed for radioactive 14C using a commercially available radiochromatogram scanner. This method was capable of detecting peaks of [14C]protein containing 50 000--1 000 000 cpm. Under optimal conditions, gels could be scanned at a rate of 1 cm per min, allowing for a... | US |
The individual and combined effects of PGD2, PGI2 and an aortic proteoglycan on human platelet aggregation and plasma clotting were studied. PGI2 was at least 10 times more potent than PGD2 in inhibiting platelet aggregation. Small doses of prostaglandins inhibited ADP- and thrombin-induced aggregation, but only prolon... | US |
The present study examined the effect of prostacyclin (PGI2) on ventricular arrhythmias following coronary artery occlusion in the cat. The left anterior descending coronary artery (LAD) was occluded abruptly in 50 cats anesthetized with alpha-chloralose. The ECG (Lead II) along with arterial blood pressure were monito... | US |
High concentrations of ethanol are effective in reducing the intermolecular cross-linking which predominates when the reactions of tetranitromethane with the carboxypeptidase inhibitor from potatoes, a chymotrypsin inhibitor also from potatoes, and insulin are carried out under standard conditions. Including reagents s... | US |
Because systemic spread occurs early in the growth of many malignancies, control of occult micrometastases must be an integral part of cancer treatment. For this reason, surgery and radiation therapy alone may fail to achieve a cure despite eradication of the primary tumor. Chemotherapy is potent and systemic in its ef... | US |
Resection of the superior tarsal muscle (STM) is effective in correcting congenital or acquired blepharoptosis in patients who have satisfactory elevation of the eyelid with a preoperative phenylephrine eye drops test. Advantages of this procedure are that only the STM is resected, the conjunctiva and basic lacrimal se... | US |
The recently published method of treatment of amblyopia by the use of rotating gratings is very similar to an older technique. Used apparently extensively during the 1930s in the United States, the method, called 'visual gyration' was based on use of a rotating disk pattern like a grating. Differences between the old a... | US |
Amino acids appear to be prime regulators of autophagy and proteolysis in liver. They both attain a maximum rapidly when livers from fed rats are perfused in the single-pass mode without amino acids and are suppressed to basal levels by amino acid additions. The fact that their greatest responsiveness to amino acids oc... | US |
The increased protein degradation associated with diabetes appears to be different in many respects from protein catabolism in normal, well-nourished cells. In all normal eukaryotic cells examined, degradation of cytosolic proteins exhibits several striking features. Large proteins tend to be degraded more rapidly than... | US |
Phototherapy has been shown to be an effective therapy for severe neonatal jaundice. However, because of its seemingly innocuous effect on normal babies, this therapeutic modality has been widely used to prevent jaundice in circumstances where it may be neither necessary nor beneficial. The present report summarizes re... | US |
Interest in the formulation of quantitative structure-activity relationships (QSAR) for antitumor drugs has begun to develop in the past decade. The work in this area has been reviewed briefly, using as examples studies on nitrosoureas, aniline mustards, and aryl triazenes. A salient conclusion from this analysis is th... | US |
Renin was extracted and purified from human, dog, hog, rat, beef, rabbit and sheep kidneys. The renin "concentration" of these preparations was determined and expressed in international (Goldblatt) units by measuring the pressor effect produced by intravascular injection into normal dogs of a permanent colony. The reni... | US |
We investigated the effect of stimuli activate the sympathetic nervous system on plasma catecholamines, renin activity, urinary metanephrine and normetanephrine, and various hemodynamic parameters in normal subjects (NIs) and borderline hypertensive (BH) subjects. No differences were observed in sympathetic nervous sys... | US |
The interrelationships of arterial pressure, plasma volume (PV), and plasma renin activity were studied in 152 consecutive male patients with uncomplicated essential hypertension. Of these, 22 (17 white and 5 black) subjects had normal plasma volumes and because of the small number were not included in the analysis of ... | US |
Irradiation can eradicate the microscopic disease that radical surgical procedures cannot remove, but high doses of irradiation fail to control large volumes of cancer. The concept "either irradiation or surgery" for all clinical situations should be eliminated. If irradiation has no place as the sole treatment for a d... | US |
The presence of acetone-soluble renin inhibitors in normal plasma has been proposed to explain the variation of plasma reactivity (PRR) in samples from normotensive and hypertensive subjects. In our experience, acetone extraction decreased PRR in relation to unextracted control values, an observation which is not consi... | US |
The response of the placental circulations to prostaglandin I2 (maternal dose 20 microgram/kg, fetal dose 180 microgram/kg) was observed in 10 near-term sheep with chronically implanted vascular catheters. The blood flows before and 90 s after the injection of prostaglandin I2 were measured using radioactive microspher... | US |
Two siblings with Cockayne syndrome (CS) are described and the literature on the subject is briefly reviewed. Of particular interest were the unusual neuropathological findings in 1 of the patients. These included microcephaly, white matter atrophy with patchy loss of myelinated fibers, calcifications of the basal gang... | US |
The need for special dietary products marketed for use by individuals with diabetes mellitus and the safety and efficacy of certain nutritive sweetener substitutes for sucrose are reviewed. Special foods for individuals with diabetes mellitus are not necessary to achieve the dietary objectives recommended by leading Un... | US |
The in vitro cloning technique for detecting megakaryocyte precursor cells was employed to compare stimuli known to influence megakaryocytopoiesis. Preparations of thrombopoietic stimulating factor (TSF) did not directly stimulate the growth of megakaryocyte colonies (CFU-m) but increased the frequency of CFU-m when TS... | US |
The biologic characteristics and specificity of rabbit anti-mouse brain (RAMB) serum for pluripotent hemopoietic stem cells (CFU-s) is reviewed. The application of RAMB serum to the functional analysis of stem cell differentiation and self renewal characteristics is discussed. Preliminary data are presented which sugge... | US |
The experiments presented test the hypothesis that pluripotential stem cells (assayed in the mouse as CFU-S) are normally not in cycle and that the failure of normal marrow transfusions to take in normal recipients is due to the absence of a stimulus to turn CFU-S into cycle. Following marrow transfusion from male dono... | US |
One hundred twenty-seven cultures were taken from donor eyes in McCarey Kaufman (M-K) media and 60 from anterior chamber cultures of whole eyes. From the 127 eyes, 17 positive culture were obtained, 13 of which came from anterior chamber cultures of the whole eye and 4 from the M-K media. Of the 16 eyes used for cornea... | US |
Prostaglandin E1 and methylprednisolone sodium succinate were administered simultaneously after shock in an intact canine hemorrhagic shock model and compared to treatment with each agent singly and with a 60 cc saline infusion. A detrimental effect of the prostaglandin E1/steroid combination was evidenced by decreased... | US |
A theoretical model for the kinetics of uptake of a putative precursor molecule into nucleotide pools and into replicating DNA has been developed. The relationship between the accumulation of radioactively labeled precursors in the pool and the appearance of radioactivity in DNA is then derived. Experiments have been c... | US |
We have examined the role of complement in eliciting a lethal response in C3H/HeJ and C3H/St mice. The results reported here indicate that endotoxin-initiated complement activation, leading to significant drops in circulating C3 levels, is not sufficient to cause lethality. The complement system in both strains was dem... | US |
Hemoglobin A1 concentrations were measured in 230 patients with diabetes mellitus. Diabetic patients controlled by diet alone had significantly lower HbA1 levels compared to the insulin or oral hypoglycemic treated groups. Only 13% of insulin-treated patients had HbA1 levels below 10%, while 26% of the oral agent treat... | US |
This study was undertaken to evaluate the hypoglycemic effects of endotoxin in C3H/HeJ (nonresponder) mice. Endotoxin from Salmonella enteritidis ser Typhimurium strain SR-11 was used and the median lethal dosed (LD50) for random-outbred Swiss-Webster mice and C3H/HeJ mice were 450 microgram and 3,000 microgram, respec... | US |
Atrial myocardium of guinea pigs was used to study effects of Escherichia coli endotoxin shock on inotropic characteristics of heart muscle free from noncardiac influences of the in vivo shock state. In vitro exposure of atrial muscle to large concentrations of endotoxin (10-1,000 microgram/ml, final concentration) for... | US |
Tissue temperature and in vitro glucose metabolism by rat soleus muscle were studied following a 3-second burn on one hind limb in 90 degrees C water. The injury increased the subcutaneous temperature in the calf of the burned limb to 53.4 +/- 0.7 (SE) degrees C and that between soleus muscle and fibula to 49.4 +/- 1.3... | US |
Corticosteroids have been reported to potentiate infections, and yet recent clinical and experimental studies have documented their therapeutic effectiveness in both septic and endotoxin shock. This study was designed to determine if methylprednisolone sodium succinate (MP) affects the clearance of live E coli organism... | US |
The influence of endotoxic administration (0.5 mg/kg) on hepatic pyruvate kinase activity in normal (nondiabetic) and diabetic dogs was investigated. Pyruvate kinase activity was not affected four hours after endotoxin injection in nondiabetic dogs. However, it was stimulated by 288% in dogs that were made diabetic pri... | US |
Psychoanalysis in America functioned first largely as an avant-garde phenomenon. Later psychoanalysis became a specialty within a bureaucratic society. Both roles help explain the importance and the limitations of freud's impact on American culture. | US |
Radiation therapy directed at the abdomen may damage the digestive tract, the type and extent of injury depending on the dose of the radiation and the radiation sensitivity of the gut. Characteristic early changes are manifest in the mucosa of the gut: for later ulceration, changes in the collagen tissues and particula... | US |
Cancer of the nose and paranasal sinuses (SNC) has been attributed to occupational exposure to nickel, chromium, radium, dichlordiethyl sulphide, isopropyl oil, and hydrocarbons. Occupational groups with an increased SNC risk include furniture, boot and show workers, and workers in U.S. countries heavily involved in bo... | US |
Aspects of the granulocyte-macrophage progenitor cell (CFU-GM) assay not previously used in the content of bone marrow transplantation were discussed in terms of the additional information which could be derived. This focused on the characteristics and responsiveness of the progenitor cells to regulatory activities and... | US |
Seventeen dogs with spontaneous generalized lymphoma in complete clinical remission induced with combination chemotherapy were given 1100 R total body irradiation (TBI) and autologous marrow grafts as consolidation therapy. Marrow was obtained immediately before TBI, stored at 4 degrees C, and infused immediately after... | US |
We have used in vitro immunotherapy before autologous bone marrow transplantation for three patients with acute lymphoblastic leukemia (ALL). Bone marrow was removed during remission, and mononuclear cells were separated by density-step centrifugation on Ficoll-Hypaque. The cells from each patient were treated with a h... | US |
From March, 1976 to February, 1979, 28 cases of adult acute leukemia of which 24 were evaluable were treated in irreversible relapse with high dose chemotherapy (piperazinedione) and supra-lethal total body irradiation (TBI) in conjunction with autologous bone marrow transplantation (ABMT). The marrow cells grafted wer... | US |
Following marrow transplantation, the clinical course of the patients is invariably complicated by severe infections due to neutropenia and immuno-incompetence. With a view to explore means of alleviating these complications, Bacillus Calmette-Guerin (BCG), methanol extraction residue of BCG (MER), Corynebacterium parv... | US |
Radiation therapy is used as total body treatment in preparation of the acute myelogenous leukemia (AML) patient for bone marrow transplantation. Many AML patients will have residual leukemia cells at the time of total body irradiation (TBI). In the present study, the effect of TBI on leukemic myeloid cells was compare... | US |
When sequential high dose drug-radiation cytoreductive regimens are employed, the interval between chemotherapy and total body irradiation (TBI) can markedly influence both toxicity in rapid cell renewal systems and the probability of successfully ablating normal and malignant hemopoietic stem cells. This is primarily ... | US |
Preliminary clinical trials using cryopreserved autologous bone marrow reinfusion have now been carried out at our institution in 5 children and 2 adults with advanced stages of neuroblastoma, rhabdomyosarcoma, non-Hodgkin's lymphoma and small cell carcinoma of the lung. Normal numbers of in vitro colony forming cells ... | US |
Ten patients with non-leukemic neoplasms received intensive, marrow-lethal doses of drugs and radiation followed by rescue with autologous cryopreserved bone marrow (nine) or marrow from an identical twin as part of a phase 1-2 study. Nine patients had extensive disease that was unresponsive to conventional therapy. Ma... | US |
Details are given of response and toxicity after high dose chemotherapy followed by autologous bone marrow infusion. High dose nitrosurea therapy (600-1000 mg/m2 BCNU) was predominantly associated with hematopoietic toxicity but recovery was within 4-5 weeks after BCNU therapy. High dose combination chemotherapy using ... | US |
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