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1
https://en.wikipedia.org/wiki/Lyme_disease
https://en.wikipedia.org/wiki/Doxycycline
What antibiotic is recommended for early localized Lyme disease in a pregnant patient with no penicillin allergy, who cannot take cephalosporins due to a severe allergy?
Amoxicillin
2
https://en.wikipedia.org/wiki/Syphilis
https://en.wikipedia.org/wiki/Penicillin_allergy
What antibiotic is recommended for treating primary syphilis in a non-pregnant patient with a documented anaphylactic penicillin allergy?
Doxycycline
3
https://en.wikipedia.org/wiki/Hyperthyroidism
https://en.wikipedia.org/wiki/Methimazole
What antithyroid medication is recommended for hyperthyroidism in a patient during the first trimester of pregnancy?
Propylthiouracil
4
https://en.wikipedia.org/wiki/Chlamydia_infection
https://en.wikipedia.org/wiki/Doxycycline
What is the recommended antibiotic for treating chlamydia in a pregnant patient?
Azithromycin
5
https://en.wikipedia.org/wiki/Invasive_candidiasis
https://en.wikipedia.org/wiki/Anidulafungin
In a patient with invasive candidiasis and decompensated liver cirrhosis, which antifungal is preferred given concern for hepatotoxicity?
Anidulafungin
6
https://en.wikipedia.org/wiki/Streptococcal_pharyngitis
https://en.wikipedia.org/wiki/Macrolide
For a patient with an immediate hypersensitivity reaction to beta-lactams being treated for streptococcal pharyngitis, which antibiotic is recommended?
Azithromycin
7
https://en.wikipedia.org/wiki/Major_depressive_disorder
https://en.wikipedia.org/wiki/Bupropion
Which antidepressant used to treat major depressive disorder is contraindicated in patients with bulimia nervosa?
Bupropion
8
https://en.wikipedia.org/wiki/Migraine
https://en.wikipedia.org/wiki/Propranolol
Which medication used for migraine prophylaxis is also indicated for hypertension and other cardiovascular conditions?
Propranolol
9
https://en.wikipedia.org/wiki/Trigeminal_neuralgia
https://en.wikipedia.org/wiki/Carbamazepine
In a patient with trigeminal neuralgia who cannot take carbamazepine due to drug-induced agranulocytosis, what is the preferred alternative treatment?
Oxcarbazepine
10
https://en.wikipedia.org/wiki/Generalized_anxiety_disorder
https://en.wikipedia.org/wiki/Benzodiazepine
In patients with generalized anxiety disorder who require long-term pharmacologic treatment, which class of anxiolytic is not recommended as a first-line therapy?
Benzodiazepines
11
https://en.wikipedia.org/wiki/Pneumocystis_pneumonia
https://en.wikipedia.org/wiki/Sulfonamide_(medicine)
What oral agent is recommended for mild Pneumocystis pneumonia in patients with a sulfonamide allergy?
Atovaquone
12
https://en.wikipedia.org/wiki/Alcohol_withdrawal_syndrome
https://en.wikipedia.org/wiki/Lorazepam
What benzodiazepine is recommended for alcohol withdrawal in patients with advanced liver cirrhosis?
Lorazepam
13
https://en.wikipedia.org/wiki/Acne_vulgaris
https://en.wikipedia.org/wiki/Retinoid
Which class of acne medications must be avoided during pregnancy due to teratogenic risk in both oral and topical formulations?
Retinoids
14
https://en.wikipedia.org/wiki/Bipolar_disorder
https://en.wikipedia.org/wiki/Lithium_(medication)
Which mood stabilizer for bipolar disorder is specifically preferred in a patient with recurrent suicidal ideation?
Lithium
15
https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug
https://en.wikipedia.org/wiki/Misoprostol
Which gastroprotective medication used alongside chronic NSAID therapy is absolutely contraindicated in women of childbearing age?
Misoprostol
16
https://en.wikipedia.org/wiki/Erectile_dysfunction
https://en.wikipedia.org/wiki/Sildenafil
What is an alternative treatment for erectile dysfunction in patients who cannot take PDE5 inhibitors due to concurrent nitrate use?
Alprostadil
17
https://en.wikipedia.org/wiki/Hyperphosphatemia
https://en.wikipedia.org/wiki/Sevelamer
What phosphate binder is recommended for hyperphosphatemia in patients with hypercalcemia?
Sevelamer
18
https://en.wikipedia.org/wiki/Acute_mountain_sickness
https://en.wikipedia.org/wiki/Acetazolamide
What medication is recommended to prevent or treat acute mountain sickness in patients who cannot take acetazolamide due to a sulfonamide allergy?
Dexamethasone
19
https://en.wikipedia.org/wiki/Esophageal_varices
https://en.wikipedia.org/wiki/Beta_blocker
What procedure or treatment is recommended to prevent esophageal variceal bleeding in patients with asthma?
Endoscopic variceal ligation
20
https://en.wikipedia.org/wiki/Tuberculosis_management
https://en.wikipedia.org/wiki/Pyrazinamide
Which antitubercular drug should be avoided in patients with acute gout?
Pyrazinamide
21
https://en.wikipedia.org/wiki/Supraventricular_tachycardia
https://en.wikipedia.org/wiki/Ebstein%27s_anomaly
What is the preferred pharmacologic treatment for terminating SVT in a patient with Ebstein's anomaly?
Procainamide
22
https://en.wikipedia.org/wiki/Gestational_hypertension
https://en.wikipedia.org/wiki/Labetalol
Which first-line antihypertensive for gestational hypertension is contraindicated in patients with asthma?
Labetalol
23
https://en.wikipedia.org/wiki/Scrub_typhus
https://en.wikipedia.org/wiki/Doxycycline
What antibiotic is recommended for treating scrub typhus during pregnancy?
Azithromycin
24
https://en.wikipedia.org/wiki/Breast_cancer
https://en.wikipedia.org/wiki/Aromatase_inhibitor
What adjuvant hormonal therapy is recommended for ER-positive breast cancer in premenopausal women?
Tamoxifen
25
https://en.wikipedia.org/wiki/Psychosis
https://en.wikipedia.org/wiki/Parkinson%27s_disease
Which antipsychotic is preferred for treating drug-induced psychosis in Parkinson's disease?
Clozapine
26
https://en.wikipedia.org/wiki/Pulmonary_embolism
https://en.wikipedia.org/wiki/Ventilation/perfusion_scan
What imaging test is preferred for suspected pulmonary embolism in a patient with iodinated contrast allergy?
V/Q scan
27
https://en.wikipedia.org/wiki/Pulmonary_embolism
https://en.wikipedia.org/wiki/Ventilation/perfusion_scan
Following a pulmonary embolism, which imaging test is recommended to screen for chronic thromboembolic pulmonary hypertension (CTEPH)?
V/Q scan
28
https://en.wikipedia.org/wiki/CT_pulmonary_angiogram
https://en.wikipedia.org/wiki/Pregnancy
What imaging test is preferred for suspected pulmonary embolism in a pregnant patient?
V/Q scan
29
https://en.wikipedia.org/wiki/Cardiac_stress_test
https://en.wikipedia.org/wiki/Asthma
What pharmacologic stress agent is preferred for cardiac stress testing in a patient with moderate-to-severe asthma with a history of bronchospasm?
Dobutamine
30
https://en.wikipedia.org/wiki/Cholecystitis
https://en.wikipedia.org/wiki/Cholescintigraphy
What imaging test is preferred for suspected acute cholecystitis when ultrasound is non-diagnostic?
HIDA scan
31
https://en.wikipedia.org/wiki/Bowel_obstruction
https://en.wikipedia.org/wiki/Medical_imaging_in_pregnancy
What imaging modality is recommended for evaluating a pregnant patient with suspected bowel obstruction when plain radiographs are to be avoided and ultrasound is inconclusive?
MRI
32
https://en.wikipedia.org/wiki/Appendicitis
https://en.wikipedia.org/wiki/Medical_imaging_in_pregnancy
What imaging test is preferred for suspected appendicitis during the second or third trimester of pregnancy?
MRI
33
https://en.wikipedia.org/wiki/Appendicitis
https://en.wikipedia.org/wiki/Pediatrics
What imaging test is preferred as first-line for suspected appendicitis in children to avoid radiation exposure?
Ultrasound
34
https://en.wikipedia.org/wiki/Myelography
https://en.wikipedia.org/wiki/Artificial_cardiac_pacemaker
What spinal imaging technique is used for patients with pacemakers who cannot undergo MRI?
CT myelogram
35
https://en.wikipedia.org/wiki/CT_scan
https://en.wikipedia.org/wiki/Artificial_cardiac_pacemaker
What imaging modality is preferred for brain imaging in a patient with an MRI-unsafe pacemaker?
CT scan
36
https://en.wikipedia.org/wiki/Renal_cell_carcinoma
https://en.wikipedia.org/wiki/Radiocontrast_agent
What imaging modality is preferred for evaluating a renal mass in a patient with an allergy to iodinated contrast material?
MRI
37
https://en.wikipedia.org/wiki/Echocardiography
https://en.wikipedia.org/wiki/Obesity
In obese patients where transthoracic echocardiography yields suboptimal images, what alternative cardiac imaging approach is recommended?
Transesophageal echocardiography (TEE)
38
https://en.wikipedia.org/wiki/Coronary_artery_disease
https://en.wikipedia.org/wiki/Chronic_kidney_disease
What cardiac imaging modality is preferred for evaluating suspected coronary artery disease in a patient with severe chronic kidney disease?
Stress echocardiography
39
https://en.wikipedia.org/wiki/Contrast-induced_nephropathy
https://en.wikipedia.org/wiki/Magnetic_resonance_angiography
What vascular imaging modality avoids iodinated contrast and is preferred in patients at high risk for contrast-induced nephropathy?
MR angiography
40
https://en.wikipedia.org/wiki/Abdominal_aortic_aneurysm
https://en.wikipedia.org/wiki/Computed_tomography_angiography
What imaging test is preferred to evaluate abdominal aortic aneurysm before endovascular repair and assess anatomic suitability?
CT angiography
41
https://en.wikipedia.org/wiki/Crohn%27s_disease
https://en.wikipedia.org/wiki/Magnetic_resonance_enterography
What imaging modality is preferred for evaluating small bowel inflammation in pediatric Crohn's disease to avoid ionizing radiation?
Magnetic Resonance Enterography
42
https://en.wikipedia.org/wiki/Stroke
https://en.wikipedia.org/wiki/Diffusion-weighted_magnetic_resonance_imaging
What imaging modality is superior to CT for detecting acute ischemic stroke in the posterior circulation involving the brainstem or cerebellum?
MRI
43
https://en.wikipedia.org/wiki/Pyloric_stenosis
https://en.wikipedia.org/wiki/Upper_gastrointestinal_series
What imaging test can confirm infantile hypertrophic pyloric stenosis when ultrasound findings are equivocal?
Upper GI series
44
https://en.wikipedia.org/wiki/Intussusception_(medical_disorder)
https://en.wikipedia.org/wiki/CT_scan
What imaging modality is preferred for diagnosing intussusception in an adult patient?
CT scan
45
https://en.wikipedia.org/wiki/Kidney_stone_disease
https://en.wikipedia.org/wiki/Medical_imaging_in_pregnancy
What imaging modality is preferred for suspected kidney stones in a pregnant patient to avoid radiation exposure?
Ultrasound
46
https://en.wikipedia.org/wiki/Deep_vein_thrombosis
https://en.wikipedia.org/wiki/Venography
What imaging modality is preferred for suspected iliofemoral deep vein thrombosis when compression ultrasound cannot adequately visualize the iliac veins?
CT venography
47
https://en.wikipedia.org/wiki/Hepatocellular_carcinoma
https://en.wikipedia.org/wiki/Chronic_kidney_disease
What imaging modality is preferred for characterizing a liver mass in a patient with chronic kidney disease who cannot receive iodinated contrast?
MRI
48
https://en.wikipedia.org/wiki/Ovarian_cyst
https://en.wikipedia.org/wiki/Magnetic_resonance_imaging
What imaging modality is recommended for further characterization of an ovarian cyst larger than 7 cm or with indeterminate features on ultrasound?
MRI
49
https://en.wikipedia.org/wiki/Lyme_disease
https://en.wikipedia.org/wiki/Amoxicillin
Which antibiotic is the most effective for early Lyme disease and does not pose fetal risk when used during pregnancy?
Amoxicillin
50
https://en.wikipedia.org/wiki/Graves%27_disease
https://en.wikipedia.org/wiki/Propylthiouracil
Which antithyroid drug is preferred over methimazole in thyroid storm due to its additional mechanism of action?
Propylthiouracil (PTU)
51
https://en.wikipedia.org/wiki/Atrial_fibrillation
https://en.wikipedia.org/wiki/Warfarin
Which anticoagulant class is required for stroke prevention in atrial fibrillation when a mechanical heart valve is present?
Warfarin (Coumadin)
52
https://en.wikipedia.org/wiki/Management_of_HIV/AIDS
https://en.wikipedia.org/wiki/Abacavir
Which antiretroviral backbone agent is chosen instead of abacavir in an HIV treatment regimen when the patient tests positive for the HLA-B*5701 allele?
Tenofovir (TDF or TAF)
53
https://en.wikipedia.org/wiki/Trigeminal_neuralgia
https://en.wikipedia.org/wiki/Carbamazepine
Which first-line anticonvulsant for trigeminal neuralgia requires pharmacogenomic screening before initiation in certain ethnic populations?
Carbamazepine
54
https://en.wikipedia.org/wiki/Gout
https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug
Which drug class is the alternative preferred treatment for an acute gout flare in a patient with active peptic ulcer disease?
Colchicine
55
https://en.wikipedia.org/wiki/Rheumatoid_arthritis
https://en.wikipedia.org/wiki/Methotrexate
Which DMARD is safe to continue for Rheumatoid Arthritis during pregnancy?
Hydroxychloroquine
56
https://en.wikipedia.org/wiki/Aspergillosis
https://en.wikipedia.org/wiki/Voriconazole
Which antifungal is most effective for invasive aspergillosis in patients with prolonged QT interval?
Amphotericin B
57
https://en.wikipedia.org/wiki/Uric_acid
https://en.wikipedia.org/wiki/Xanthic_urolithiasis
A patient receiving allopurinol for hyperuricemia develops radiolucent kidney stones due to increased xanthine excretion. Which type of urolithiasis has developed as a complication of uric acid-lowering therapy?
Xanthic urolithiasis
58
https://en.wikipedia.org/wiki/Ankylosing_spondylitis
https://en.wikipedia.org/wiki/Secukinumab
In a patient with ankylosing spondylitis who has had an inadequate response to TNF inhibitor therapy, which alternative biologic is recommended?
Secukinumab
59
https://en.wikipedia.org/wiki/Cholangitis,_primary_sclerosing
https://en.wikipedia.org/wiki/Jaundice
What is the most effective treatment for cholestatic pruritus in primary sclerosing cholangitis?
Cholestyramine
60
https://en.wikipedia.org/wiki/Ankylosing_spondylitis
https://en.wikipedia.org/wiki/Methotrexate
Which conventional DMARD is used for peripheral arthritis in ankylosing spondylitis but requires regular hepatic monitoring?
Methotrexate
61
https://en.wikipedia.org/wiki/Cortisol
https://en.wikipedia.org/wiki/Adrenogenital_syndrome
In a growing child with congenital adrenal hyperplasia, which glucocorticoid is preferred for cortisol replacement to minimize growth suppression?
Hydrocortisone
62
https://en.wikipedia.org/wiki/Lymphoma
https://en.wikipedia.org/wiki/Epstein%E2%80%93Barr_virus%E2%80%93associated_lymphoproliferative_diseases
Which immunotherapy is most effective for lymphoma-spectrum disease in EBV-associated lymphoproliferative condition?
Rituximab
63
https://en.wikipedia.org/wiki/Tyrosinemia
https://en.wikipedia.org/wiki/Tetrahydrobiopterin
In tyrosinemia type I, which drug prevents the toxic accumulation of succinylacetone by blocking an upstream enzyme in the tyrosine degradation pathway?
Nitisinone (NTBC)
64
https://en.wikipedia.org/wiki/Hymenolepiasis
https://en.wikipedia.org/wiki/Praziquantel
What is the most effective treatment for hymenolepiasis in high-burden autoinfection?
Praziquantel
65
https://en.wikipedia.org/wiki/Gestational_trophoblastic_disease
https://en.wikipedia.org/wiki/Dactinomycin
What is the most effective chemotherapy for gestational trophoblastic neoplasia in low-risk disease?
Dactinomycin
66
https://en.wikipedia.org/wiki/Glioblastoma
https://en.wikipedia.org/wiki/Temozolomide
What is the most effective chemotherapy for glioblastoma in MGMT-promoter-methylated tumors?
Temozolomide
67
https://en.wikipedia.org/wiki/Melanoma
https://en.wikipedia.org/wiki/Dabrafenib
Which targeted therapy is indicated for unresectable or metastatic melanoma with a BRAF V600E mutation?
Dabrafenib
68
https://en.wikipedia.org/wiki/Hepatocellular_carcinoma
https://en.wikipedia.org/wiki/Sorafenib
Which targeted therapy is first-line for advanced (BCLC-C) unresectable hepatocellular carcinoma?
Sorafenib
69
https://en.wikipedia.org/wiki/Hepatocellular_carcinoma
https://en.wikipedia.org/wiki/Cabozantinib
Which targeted therapy is indicated for hepatocellular carcinoma with Child-Pugh A liver function after progression on first-line sorafenib?
Cabozantinib
70
https://en.wikipedia.org/wiki/Atrial_fibrillation
https://en.wikipedia.org/wiki/Warfarin
Which oral anticoagulant used in atrial fibrillation requires regular INR monitoring?
Warfarin
71
https://en.wikipedia.org/wiki/Glaucoma
https://en.wikipedia.org/wiki/Betaxolol
Which topical beta-blocker is preferred for treating glaucoma for the patient with a history of severe asthma?
Betaxolol
72
https://en.wikipedia.org/wiki/Migraine
https://en.wikipedia.org/wiki/Topiramate
Which migraine prophylactic medication is preferred for a patient with comorbid asthma?
Topiramate
73
https://en.wikipedia.org/wiki/Pain_management
https://en.wikipedia.org/wiki/Acetaminophen
Which analgesic is preferred for treating mild pain for a patient with active peptic ulcer disease?
Acetaminophen
74
https://en.wikipedia.org/wiki/Bipolar_disorder
https://en.wikipedia.org/wiki/Lamotrigine
Which mood stabilizer is preferred for treating bipolar disorder because the patient is currently pregnant and valproate is contraindicated?
Lamotrigine
75
https://en.wikipedia.org/wiki/Attention_deficit_hyperactivity_disorder
https://en.wikipedia.org/wiki/Atomoxetine
Which ADHD medication is preferred for a patient who has a personal history of stimulant substance use disorder?
Atomoxetine
76
https://en.wikipedia.org/wiki/Urinary_tract_infection
https://en.wikipedia.org/wiki/Cephalexin
Which antibiotic is preferred for treating a simple urinary tract infection in a patient who is in their third trimester of pregnancy?
Cephalexin
77
https://en.wikipedia.org/wiki/Insomnia
https://en.wikipedia.org/wiki/Ramelteon
Which hypnotic medication is preferred for a patient who has severe chronic obstructive pulmonary disease (COPD)?
Ramelteon
78
https://en.wikipedia.org/wiki/Hypercholesterolemia
https://en.wikipedia.org/wiki/Cholestyramine
Which lipid-lowering medication is preferred for a patient who is pregnant?
Cholestyramine
79
https://en.wikipedia.org/wiki/Schizophrenia
https://en.wikipedia.org/wiki/Ziprasidone
Which antipsychotic is preferred for a patient who has pre-existing metabolic syndrome?
Ziprasidone
80
https://en.wikipedia.org/wiki/Osteoporosis
https://en.wikipedia.org/wiki/Denosumab
Which pharmacological treatment is preferred for a patient who has osteoporosis and Stage 4 chronic kidney disease?
Denosumab
81
https://en.wikipedia.org/wiki/Major_depressive_disorder
https://en.wikipedia.org/wiki/Bupropion
Which antidepressant approved for major depressive disorder is also FDA-approved as a smoking cessation aid?
Bupropion
82
https://en.wikipedia.org/wiki/Benign_prostatic_hyperplasia
https://en.wikipedia.org/wiki/Tamsulosin
Which alpha-blocker is preferred for a patient who has benign prostatic hyperplasia and significant orthostatic hypotension?
Tamsulosin
83
https://en.wikipedia.org/wiki/Stroke
https://en.wikipedia.org/wiki/Clopidogrel
Which antiplatelet medication is preferred for secondary stroke prevention in a patient who has a confirmed aspirin allergy?
Clopidogrel
84
https://en.wikipedia.org/wiki/Psoriasis
https://en.wikipedia.org/wiki/TNF_inhibitor
Which class of biologic agents used for moderate-to-severe plaque psoriasis is contraindicated in patients with NYHA Class III or IV heart failure?
TNF inhibitors (anti-TNF biologics)
85
https://en.wikipedia.org/wiki/Hyperuricemia
https://en.wikipedia.org/wiki/Probenecid
Which medication is preferred for hyperuricemia in a patient who has chronic kidney disease with CrCl < 30 mL/min?
Allopurinol
86
https://en.wikipedia.org/wiki/Rheumatoid_arthritis
https://en.wikipedia.org/wiki/Methotrexate
In a patient with rheumatoid arthritis on methotrexate who develops stomatitis and gastrointestinal side effects, which supplement is co-prescribed to reduce these adverse effects?
Folic acid
87
https://en.wikipedia.org/wiki/Smoking_cessation
https://en.wikipedia.org/wiki/Bupropion
Which pharmacotherapy approved for smoking cessation should be avoided in patients with a history of epilepsy or seizure disorder?
Bupropion
88
https://en.wikipedia.org/wiki/Allergic_rhinitis
https://en.wikipedia.org/wiki/Diphenhydramine
Which antihistamine is preferred for allergic rhinitis in an elderly patient who has symptomatic benign prostatic hyperplasia?
Loratadine
89
https://en.wikipedia.org/wiki/Diabetic_neuropathy
https://en.wikipedia.org/wiki/Amitriptyline
Which medication is preferred for diabetic neuropathy in a patient who has a second-degree atrioventricular block?
Gabapentin
90
https://en.wikipedia.org/wiki/Generalized_anxiety_disorder
https://en.wikipedia.org/wiki/Myasthenia_gravis
Which anxiolytic is preferred for generalized anxiety disorder in a patient who has Myasthenia Gravis?
Buspirone
91
https://en.wikipedia.org/wiki/Obsessive%E2%80%93compulsive_disorder
https://en.wikipedia.org/wiki/Citalopram
Which medication used in obsessive-compulsive disorder carries a dose-dependent risk of QTc prolongation and should be avoided in patients with cardiac conduction abnormalities?
Citalopram
92
https://en.wikipedia.org/wiki/Essential_tremor
https://en.wikipedia.org/wiki/Primidone
Which medication is used as second-line therapy for essential tremor in patients who cannot tolerate propranolol?
Primidone
93
https://en.wikipedia.org/wiki/Tuberculosis
https://en.wikipedia.org/wiki/Rifabutin
Which antimycobacterial drug should be replaced in the RIPE regimen for a patient who is HIV-positive and receiving protease inhibitors?
Rifabutin
94
https://en.wikipedia.org/wiki/Hyperkalemia
https://en.wikipedia.org/wiki/Sodium_polystyrene_sulfonate
In a patient with hyperkalemia and a history of obstructive bowel disease, which potassium-lowering agent is preferred?
Sodium zirconium cyclosilicate
95
https://en.wikipedia.org/wiki/Syphilis
https://en.wikipedia.org/wiki/Doxycycline
In a pregnant patient with primary syphilis and a confirmed penicillin allergy, what is the recommended approach to enable safe treatment?
Penicillin desensitization
96
https://en.wikipedia.org/wiki/Chlamydia_infection
https://en.wikipedia.org/wiki/Azithromycin
In a non-pregnant patient with uncomplicated chlamydia who has a documented macrolide allergy precluding azithromycin use, which antibiotic is the preferred alternative?
Doxycycline
97
https://en.wikipedia.org/wiki/Cardiac_stress_test
https://en.wikipedia.org/wiki/Chronic_obstructive_pulmonary_disease
In a patient with stable COPD requiring pharmacologic cardiac stress testing, which vasodilator stress agent is preferred to minimize bronchospasm risk?
Regadenoson
98
https://en.wikipedia.org/wiki/Warfarin
https://en.wikipedia.org/wiki/Low-molecular-weight_heparin
In a pregnant patient requiring anticoagulation for venous thromboembolism, what is substituted for warfarin?
Low-molecular-weight heparin (LMWH)
99
https://en.wikipedia.org/wiki/Tyrosinemia
https://en.wikipedia.org/wiki/Nitisinone
In a patient with tyrosinemia type I on nitisinone therapy, what dietary intervention is mandatory to prevent ocular complications?
Restriction of tyrosine and phenylalanine intake
100
https://en.wikipedia.org/wiki/Acute_pancreatitis
https://en.wikipedia.org/wiki/Magnetic_resonance_imaging
In a patient with acute pancreatitis where ultrasound is inconclusive for choledocholithiasis, what non-invasive imaging technique is preferred for evaluating the biliary and pancreatic ducts?
MRCP (Magnetic Resonance Cholangiopancreatography)

CondMedQA

A diagnostic benchmark of 100 condition-dependent biomedical questions where the correct answer changes based on patient-specific factors such as comorbidities, allergies, pregnancy status, and contraindications.

Dataset Description

Real-world clinical reasoning is inherently conditional: treatment decisions depend on patient-specific factors such as comorbidities, drug allergies, pregnancy, and organ function. Existing biomedical QA benchmarks largely ignore this conditionality, testing only context-free factual recall.

CondMedQA fills this gap with 100 expert-curated questions that require reasoning over two Wikipedia source articles to arrive at a condition-appropriate answer. Each question presents a clinical scenario where the standard-of-care answer is modified by a specific patient condition.

Key Properties

  • Domain: Biomedical / clinical pharmacology / diagnostic imaging
  • Question type: Short-answer, condition-dependent
  • Multi-hop: Every question requires evidence from 2 source articles
  • Total questions: 100
  • Answer length: Typically 1–5 words
  • Split: Test only (diagnostic benchmark)

Dataset Format

A single CSV file (condmedqa.csv) with the following columns:

Column Description
id Question identifier (1–100)
wiki1 URL of the first Wikipedia source article (primary condition/disease)
wiki2 URL of the second Wikipedia source article (drug/test/modifier)
q The clinical question with patient-specific conditions
a The condition-appropriate answer

Usage

from datasets import load_dataset

dataset = load_dataset("jashparekh/CondMedQA")

Or directly:

import pandas as pd

df = pd.read_csv("condmedqa.csv")

Intended Use

  • Evaluating LLMs on condition-dependent clinical reasoning
  • Benchmarking retrieval-augmented generation (RAG) pipelines on context-sensitive medical QA
  • Testing whether models can integrate patient-specific constraints with medical knowledge
  • Diagnostic evaluation (100 questions — not intended as a training set)

Citation

@article{parekh2026conditiongated,
  title={Condition-Gated Reasoning for Context-Dependent Biomedical Question Answering},
  author={Parekh, Jash Rajesh and Kweon, Wonbin and Chan, Joey and Islamaj, Rezarta and Leaman, Robert and Jiang, Pengcheng and Wei, Chih-Hsuan and Wang, Zhizheng and Lu, Zhiyong and Han, Jiawei},
  journal={arXiv preprint arXiv:2602.17911},
  year={2026}
}

License

MIT

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