Datasets:
id int64 1 100 | wiki1 stringlengths 34 70 | wiki2 stringlengths 36 104 | q stringlengths 72 211 | a stringlengths 3 50 |
|---|---|---|---|---|
1 | https://en.wikipedia.org/wiki/Lyme_disease | https://en.wikipedia.org/wiki/Doxycycline | What antibiotic is recommended for early localized Lyme disease in a pregnant patient with no penicillin allergy, who cannot take cephalosporins due to a severe allergy? | Amoxicillin |
2 | https://en.wikipedia.org/wiki/Syphilis | https://en.wikipedia.org/wiki/Penicillin_allergy | What antibiotic is recommended for treating primary syphilis in a non-pregnant patient with a documented anaphylactic penicillin allergy? | Doxycycline |
3 | https://en.wikipedia.org/wiki/Hyperthyroidism | https://en.wikipedia.org/wiki/Methimazole | What antithyroid medication is recommended for hyperthyroidism in a patient during the first trimester of pregnancy? | Propylthiouracil |
4 | https://en.wikipedia.org/wiki/Chlamydia_infection | https://en.wikipedia.org/wiki/Doxycycline | What is the recommended antibiotic for treating chlamydia in a pregnant patient? | Azithromycin |
5 | https://en.wikipedia.org/wiki/Invasive_candidiasis | https://en.wikipedia.org/wiki/Anidulafungin | In a patient with invasive candidiasis and decompensated liver cirrhosis, which antifungal is preferred given concern for hepatotoxicity? | Anidulafungin |
6 | https://en.wikipedia.org/wiki/Streptococcal_pharyngitis | https://en.wikipedia.org/wiki/Macrolide | For a patient with an immediate hypersensitivity reaction to beta-lactams being treated for streptococcal pharyngitis, which antibiotic is recommended? | Azithromycin |
7 | https://en.wikipedia.org/wiki/Major_depressive_disorder | https://en.wikipedia.org/wiki/Bupropion | Which antidepressant used to treat major depressive disorder is contraindicated in patients with bulimia nervosa? | Bupropion |
8 | https://en.wikipedia.org/wiki/Migraine | https://en.wikipedia.org/wiki/Propranolol | Which medication used for migraine prophylaxis is also indicated for hypertension and other cardiovascular conditions? | Propranolol |
9 | https://en.wikipedia.org/wiki/Trigeminal_neuralgia | https://en.wikipedia.org/wiki/Carbamazepine | In a patient with trigeminal neuralgia who cannot take carbamazepine due to drug-induced agranulocytosis, what is the preferred alternative treatment? | Oxcarbazepine |
10 | https://en.wikipedia.org/wiki/Generalized_anxiety_disorder | https://en.wikipedia.org/wiki/Benzodiazepine | In patients with generalized anxiety disorder who require long-term pharmacologic treatment, which class of anxiolytic is not recommended as a first-line therapy? | Benzodiazepines |
11 | https://en.wikipedia.org/wiki/Pneumocystis_pneumonia | https://en.wikipedia.org/wiki/Sulfonamide_(medicine) | What oral agent is recommended for mild Pneumocystis pneumonia in patients with a sulfonamide allergy? | Atovaquone |
12 | https://en.wikipedia.org/wiki/Alcohol_withdrawal_syndrome | https://en.wikipedia.org/wiki/Lorazepam | What benzodiazepine is recommended for alcohol withdrawal in patients with advanced liver cirrhosis? | Lorazepam |
13 | https://en.wikipedia.org/wiki/Acne_vulgaris | https://en.wikipedia.org/wiki/Retinoid | Which class of acne medications must be avoided during pregnancy due to teratogenic risk in both oral and topical formulations? | Retinoids |
14 | https://en.wikipedia.org/wiki/Bipolar_disorder | https://en.wikipedia.org/wiki/Lithium_(medication) | Which mood stabilizer for bipolar disorder is specifically preferred in a patient with recurrent suicidal ideation? | Lithium |
15 | https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug | https://en.wikipedia.org/wiki/Misoprostol | Which gastroprotective medication used alongside chronic NSAID therapy is absolutely contraindicated in women of childbearing age? | Misoprostol |
16 | https://en.wikipedia.org/wiki/Erectile_dysfunction | https://en.wikipedia.org/wiki/Sildenafil | What is an alternative treatment for erectile dysfunction in patients who cannot take PDE5 inhibitors due to concurrent nitrate use? | Alprostadil |
17 | https://en.wikipedia.org/wiki/Hyperphosphatemia | https://en.wikipedia.org/wiki/Sevelamer | What phosphate binder is recommended for hyperphosphatemia in patients with hypercalcemia? | Sevelamer |
18 | https://en.wikipedia.org/wiki/Acute_mountain_sickness | https://en.wikipedia.org/wiki/Acetazolamide | What medication is recommended to prevent or treat acute mountain sickness in patients who cannot take acetazolamide due to a sulfonamide allergy? | Dexamethasone |
19 | https://en.wikipedia.org/wiki/Esophageal_varices | https://en.wikipedia.org/wiki/Beta_blocker | What procedure or treatment is recommended to prevent esophageal variceal bleeding in patients with asthma? | Endoscopic variceal ligation |
20 | https://en.wikipedia.org/wiki/Tuberculosis_management | https://en.wikipedia.org/wiki/Pyrazinamide | Which antitubercular drug should be avoided in patients with acute gout? | Pyrazinamide |
21 | https://en.wikipedia.org/wiki/Supraventricular_tachycardia | https://en.wikipedia.org/wiki/Ebstein%27s_anomaly | What is the preferred pharmacologic treatment for terminating SVT in a patient with Ebstein's anomaly? | Procainamide |
22 | https://en.wikipedia.org/wiki/Gestational_hypertension | https://en.wikipedia.org/wiki/Labetalol | Which first-line antihypertensive for gestational hypertension is contraindicated in patients with asthma? | Labetalol |
23 | https://en.wikipedia.org/wiki/Scrub_typhus | https://en.wikipedia.org/wiki/Doxycycline | What antibiotic is recommended for treating scrub typhus during pregnancy? | Azithromycin |
24 | https://en.wikipedia.org/wiki/Breast_cancer | https://en.wikipedia.org/wiki/Aromatase_inhibitor | What adjuvant hormonal therapy is recommended for ER-positive breast cancer in premenopausal women? | Tamoxifen |
25 | https://en.wikipedia.org/wiki/Psychosis | https://en.wikipedia.org/wiki/Parkinson%27s_disease | Which antipsychotic is preferred for treating drug-induced psychosis in Parkinson's disease? | Clozapine |
26 | https://en.wikipedia.org/wiki/Pulmonary_embolism | https://en.wikipedia.org/wiki/Ventilation/perfusion_scan | What imaging test is preferred for suspected pulmonary embolism in a patient with iodinated contrast allergy? | V/Q scan |
27 | https://en.wikipedia.org/wiki/Pulmonary_embolism | https://en.wikipedia.org/wiki/Ventilation/perfusion_scan | Following a pulmonary embolism, which imaging test is recommended to screen for chronic thromboembolic pulmonary hypertension (CTEPH)? | V/Q scan |
28 | https://en.wikipedia.org/wiki/CT_pulmonary_angiogram | https://en.wikipedia.org/wiki/Pregnancy | What imaging test is preferred for suspected pulmonary embolism in a pregnant patient? | V/Q scan |
29 | https://en.wikipedia.org/wiki/Cardiac_stress_test | https://en.wikipedia.org/wiki/Asthma | What pharmacologic stress agent is preferred for cardiac stress testing in a patient with moderate-to-severe asthma with a history of bronchospasm? | Dobutamine |
30 | https://en.wikipedia.org/wiki/Cholecystitis | https://en.wikipedia.org/wiki/Cholescintigraphy | What imaging test is preferred for suspected acute cholecystitis when ultrasound is non-diagnostic? | HIDA scan |
31 | https://en.wikipedia.org/wiki/Bowel_obstruction | https://en.wikipedia.org/wiki/Medical_imaging_in_pregnancy | What imaging modality is recommended for evaluating a pregnant patient with suspected bowel obstruction when plain radiographs are to be avoided and ultrasound is inconclusive? | MRI |
32 | https://en.wikipedia.org/wiki/Appendicitis | https://en.wikipedia.org/wiki/Medical_imaging_in_pregnancy | What imaging test is preferred for suspected appendicitis during the second or third trimester of pregnancy? | MRI |
33 | https://en.wikipedia.org/wiki/Appendicitis | https://en.wikipedia.org/wiki/Pediatrics | What imaging test is preferred as first-line for suspected appendicitis in children to avoid radiation exposure? | Ultrasound |
34 | https://en.wikipedia.org/wiki/Myelography | https://en.wikipedia.org/wiki/Artificial_cardiac_pacemaker | What spinal imaging technique is used for patients with pacemakers who cannot undergo MRI? | CT myelogram |
35 | https://en.wikipedia.org/wiki/CT_scan | https://en.wikipedia.org/wiki/Artificial_cardiac_pacemaker | What imaging modality is preferred for brain imaging in a patient with an MRI-unsafe pacemaker? | CT scan |
36 | https://en.wikipedia.org/wiki/Renal_cell_carcinoma | https://en.wikipedia.org/wiki/Radiocontrast_agent | What imaging modality is preferred for evaluating a renal mass in a patient with an allergy to iodinated contrast material? | MRI |
37 | https://en.wikipedia.org/wiki/Echocardiography | https://en.wikipedia.org/wiki/Obesity | In obese patients where transthoracic echocardiography yields suboptimal images, what alternative cardiac imaging approach is recommended? | Transesophageal echocardiography (TEE) |
38 | https://en.wikipedia.org/wiki/Coronary_artery_disease | https://en.wikipedia.org/wiki/Chronic_kidney_disease | What cardiac imaging modality is preferred for evaluating suspected coronary artery disease in a patient with severe chronic kidney disease? | Stress echocardiography |
39 | https://en.wikipedia.org/wiki/Contrast-induced_nephropathy | https://en.wikipedia.org/wiki/Magnetic_resonance_angiography | What vascular imaging modality avoids iodinated contrast and is preferred in patients at high risk for contrast-induced nephropathy? | MR angiography |
40 | https://en.wikipedia.org/wiki/Abdominal_aortic_aneurysm | https://en.wikipedia.org/wiki/Computed_tomography_angiography | What imaging test is preferred to evaluate abdominal aortic aneurysm before endovascular repair and assess anatomic suitability? | CT angiography |
41 | https://en.wikipedia.org/wiki/Crohn%27s_disease | https://en.wikipedia.org/wiki/Magnetic_resonance_enterography | What imaging modality is preferred for evaluating small bowel inflammation in pediatric Crohn's disease to avoid ionizing radiation? | Magnetic Resonance Enterography |
42 | https://en.wikipedia.org/wiki/Stroke | https://en.wikipedia.org/wiki/Diffusion-weighted_magnetic_resonance_imaging | What imaging modality is superior to CT for detecting acute ischemic stroke in the posterior circulation involving the brainstem or cerebellum? | MRI |
43 | https://en.wikipedia.org/wiki/Pyloric_stenosis | https://en.wikipedia.org/wiki/Upper_gastrointestinal_series | What imaging test can confirm infantile hypertrophic pyloric stenosis when ultrasound findings are equivocal? | Upper GI series |
44 | https://en.wikipedia.org/wiki/Intussusception_(medical_disorder) | https://en.wikipedia.org/wiki/CT_scan | What imaging modality is preferred for diagnosing intussusception in an adult patient? | CT scan |
45 | https://en.wikipedia.org/wiki/Kidney_stone_disease | https://en.wikipedia.org/wiki/Medical_imaging_in_pregnancy | What imaging modality is preferred for suspected kidney stones in a pregnant patient to avoid radiation exposure? | Ultrasound |
46 | https://en.wikipedia.org/wiki/Deep_vein_thrombosis | https://en.wikipedia.org/wiki/Venography | What imaging modality is preferred for suspected iliofemoral deep vein thrombosis when compression ultrasound cannot adequately visualize the iliac veins? | CT venography |
47 | https://en.wikipedia.org/wiki/Hepatocellular_carcinoma | https://en.wikipedia.org/wiki/Chronic_kidney_disease | What imaging modality is preferred for characterizing a liver mass in a patient with chronic kidney disease who cannot receive iodinated contrast? | MRI |
48 | https://en.wikipedia.org/wiki/Ovarian_cyst | https://en.wikipedia.org/wiki/Magnetic_resonance_imaging | What imaging modality is recommended for further characterization of an ovarian cyst larger than 7 cm or with indeterminate features on ultrasound? | MRI |
49 | https://en.wikipedia.org/wiki/Lyme_disease | https://en.wikipedia.org/wiki/Amoxicillin | Which antibiotic is the most effective for early Lyme disease and does not pose fetal risk when used during pregnancy? | Amoxicillin |
50 | https://en.wikipedia.org/wiki/Graves%27_disease | https://en.wikipedia.org/wiki/Propylthiouracil | Which antithyroid drug is preferred over methimazole in thyroid storm due to its additional mechanism of action? | Propylthiouracil (PTU) |
51 | https://en.wikipedia.org/wiki/Atrial_fibrillation | https://en.wikipedia.org/wiki/Warfarin | Which anticoagulant class is required for stroke prevention in atrial fibrillation when a mechanical heart valve is present? | Warfarin (Coumadin) |
52 | https://en.wikipedia.org/wiki/Management_of_HIV/AIDS | https://en.wikipedia.org/wiki/Abacavir | Which antiretroviral backbone agent is chosen instead of abacavir in an HIV treatment regimen when the patient tests positive for the HLA-B*5701 allele? | Tenofovir (TDF or TAF) |
53 | https://en.wikipedia.org/wiki/Trigeminal_neuralgia | https://en.wikipedia.org/wiki/Carbamazepine | Which first-line anticonvulsant for trigeminal neuralgia requires pharmacogenomic screening before initiation in certain ethnic populations? | Carbamazepine |
54 | https://en.wikipedia.org/wiki/Gout | https://en.wikipedia.org/wiki/Nonsteroidal_anti-inflammatory_drug | Which drug class is the alternative preferred treatment for an acute gout flare in a patient with active peptic ulcer disease? | Colchicine |
55 | https://en.wikipedia.org/wiki/Rheumatoid_arthritis | https://en.wikipedia.org/wiki/Methotrexate | Which DMARD is safe to continue for Rheumatoid Arthritis during pregnancy? | Hydroxychloroquine |
56 | https://en.wikipedia.org/wiki/Aspergillosis | https://en.wikipedia.org/wiki/Voriconazole | Which antifungal is most effective for invasive aspergillosis in patients with prolonged QT interval? | Amphotericin B |
57 | https://en.wikipedia.org/wiki/Uric_acid | https://en.wikipedia.org/wiki/Xanthic_urolithiasis | A patient receiving allopurinol for hyperuricemia develops radiolucent kidney stones due to increased xanthine excretion. Which type of urolithiasis has developed as a complication of uric acid-lowering therapy? | Xanthic urolithiasis |
58 | https://en.wikipedia.org/wiki/Ankylosing_spondylitis | https://en.wikipedia.org/wiki/Secukinumab | In a patient with ankylosing spondylitis who has had an inadequate response to TNF inhibitor therapy, which alternative biologic is recommended? | Secukinumab |
59 | https://en.wikipedia.org/wiki/Cholangitis,_primary_sclerosing | https://en.wikipedia.org/wiki/Jaundice | What is the most effective treatment for cholestatic pruritus in primary sclerosing cholangitis? | Cholestyramine |
60 | https://en.wikipedia.org/wiki/Ankylosing_spondylitis | https://en.wikipedia.org/wiki/Methotrexate | Which conventional DMARD is used for peripheral arthritis in ankylosing spondylitis but requires regular hepatic monitoring? | Methotrexate |
61 | https://en.wikipedia.org/wiki/Cortisol | https://en.wikipedia.org/wiki/Adrenogenital_syndrome | In a growing child with congenital adrenal hyperplasia, which glucocorticoid is preferred for cortisol replacement to minimize growth suppression? | Hydrocortisone |
62 | https://en.wikipedia.org/wiki/Lymphoma | https://en.wikipedia.org/wiki/Epstein%E2%80%93Barr_virus%E2%80%93associated_lymphoproliferative_diseases | Which immunotherapy is most effective for lymphoma-spectrum disease in EBV-associated lymphoproliferative condition? | Rituximab |
63 | https://en.wikipedia.org/wiki/Tyrosinemia | https://en.wikipedia.org/wiki/Tetrahydrobiopterin | In tyrosinemia type I, which drug prevents the toxic accumulation of succinylacetone by blocking an upstream enzyme in the tyrosine degradation pathway? | Nitisinone (NTBC) |
64 | https://en.wikipedia.org/wiki/Hymenolepiasis | https://en.wikipedia.org/wiki/Praziquantel | What is the most effective treatment for hymenolepiasis in high-burden autoinfection? | Praziquantel |
65 | https://en.wikipedia.org/wiki/Gestational_trophoblastic_disease | https://en.wikipedia.org/wiki/Dactinomycin | What is the most effective chemotherapy for gestational trophoblastic neoplasia in low-risk disease? | Dactinomycin |
66 | https://en.wikipedia.org/wiki/Glioblastoma | https://en.wikipedia.org/wiki/Temozolomide | What is the most effective chemotherapy for glioblastoma in MGMT-promoter-methylated tumors? | Temozolomide |
67 | https://en.wikipedia.org/wiki/Melanoma | https://en.wikipedia.org/wiki/Dabrafenib | Which targeted therapy is indicated for unresectable or metastatic melanoma with a BRAF V600E mutation? | Dabrafenib |
68 | https://en.wikipedia.org/wiki/Hepatocellular_carcinoma | https://en.wikipedia.org/wiki/Sorafenib | Which targeted therapy is first-line for advanced (BCLC-C) unresectable hepatocellular carcinoma? | Sorafenib |
69 | https://en.wikipedia.org/wiki/Hepatocellular_carcinoma | https://en.wikipedia.org/wiki/Cabozantinib | Which targeted therapy is indicated for hepatocellular carcinoma with Child-Pugh A liver function after progression on first-line sorafenib? | Cabozantinib |
70 | https://en.wikipedia.org/wiki/Atrial_fibrillation | https://en.wikipedia.org/wiki/Warfarin | Which oral anticoagulant used in atrial fibrillation requires regular INR monitoring? | Warfarin |
71 | https://en.wikipedia.org/wiki/Glaucoma | https://en.wikipedia.org/wiki/Betaxolol | Which topical beta-blocker is preferred for treating glaucoma for the patient with a history of severe asthma? | Betaxolol |
72 | https://en.wikipedia.org/wiki/Migraine | https://en.wikipedia.org/wiki/Topiramate | Which migraine prophylactic medication is preferred for a patient with comorbid asthma? | Topiramate |
73 | https://en.wikipedia.org/wiki/Pain_management | https://en.wikipedia.org/wiki/Acetaminophen | Which analgesic is preferred for treating mild pain for a patient with active peptic ulcer disease? | Acetaminophen |
74 | https://en.wikipedia.org/wiki/Bipolar_disorder | https://en.wikipedia.org/wiki/Lamotrigine | Which mood stabilizer is preferred for treating bipolar disorder because the patient is currently pregnant and valproate is contraindicated? | Lamotrigine |
75 | https://en.wikipedia.org/wiki/Attention_deficit_hyperactivity_disorder | https://en.wikipedia.org/wiki/Atomoxetine | Which ADHD medication is preferred for a patient who has a personal history of stimulant substance use disorder? | Atomoxetine |
76 | https://en.wikipedia.org/wiki/Urinary_tract_infection | https://en.wikipedia.org/wiki/Cephalexin | Which antibiotic is preferred for treating a simple urinary tract infection in a patient who is in their third trimester of pregnancy? | Cephalexin |
77 | https://en.wikipedia.org/wiki/Insomnia | https://en.wikipedia.org/wiki/Ramelteon | Which hypnotic medication is preferred for a patient who has severe chronic obstructive pulmonary disease (COPD)? | Ramelteon |
78 | https://en.wikipedia.org/wiki/Hypercholesterolemia | https://en.wikipedia.org/wiki/Cholestyramine | Which lipid-lowering medication is preferred for a patient who is pregnant? | Cholestyramine |
79 | https://en.wikipedia.org/wiki/Schizophrenia | https://en.wikipedia.org/wiki/Ziprasidone | Which antipsychotic is preferred for a patient who has pre-existing metabolic syndrome? | Ziprasidone |
80 | https://en.wikipedia.org/wiki/Osteoporosis | https://en.wikipedia.org/wiki/Denosumab | Which pharmacological treatment is preferred for a patient who has osteoporosis and Stage 4 chronic kidney disease? | Denosumab |
81 | https://en.wikipedia.org/wiki/Major_depressive_disorder | https://en.wikipedia.org/wiki/Bupropion | Which antidepressant approved for major depressive disorder is also FDA-approved as a smoking cessation aid? | Bupropion |
82 | https://en.wikipedia.org/wiki/Benign_prostatic_hyperplasia | https://en.wikipedia.org/wiki/Tamsulosin | Which alpha-blocker is preferred for a patient who has benign prostatic hyperplasia and significant orthostatic hypotension? | Tamsulosin |
83 | https://en.wikipedia.org/wiki/Stroke | https://en.wikipedia.org/wiki/Clopidogrel | Which antiplatelet medication is preferred for secondary stroke prevention in a patient who has a confirmed aspirin allergy? | Clopidogrel |
84 | https://en.wikipedia.org/wiki/Psoriasis | https://en.wikipedia.org/wiki/TNF_inhibitor | Which class of biologic agents used for moderate-to-severe plaque psoriasis is contraindicated in patients with NYHA Class III or IV heart failure? | TNF inhibitors (anti-TNF biologics) |
85 | https://en.wikipedia.org/wiki/Hyperuricemia | https://en.wikipedia.org/wiki/Probenecid | Which medication is preferred for hyperuricemia in a patient who has chronic kidney disease with CrCl < 30 mL/min? | Allopurinol |
86 | https://en.wikipedia.org/wiki/Rheumatoid_arthritis | https://en.wikipedia.org/wiki/Methotrexate | In a patient with rheumatoid arthritis on methotrexate who develops stomatitis and gastrointestinal side effects, which supplement is co-prescribed to reduce these adverse effects? | Folic acid |
87 | https://en.wikipedia.org/wiki/Smoking_cessation | https://en.wikipedia.org/wiki/Bupropion | Which pharmacotherapy approved for smoking cessation should be avoided in patients with a history of epilepsy or seizure disorder? | Bupropion |
88 | https://en.wikipedia.org/wiki/Allergic_rhinitis | https://en.wikipedia.org/wiki/Diphenhydramine | Which antihistamine is preferred for allergic rhinitis in an elderly patient who has symptomatic benign prostatic hyperplasia? | Loratadine |
89 | https://en.wikipedia.org/wiki/Diabetic_neuropathy | https://en.wikipedia.org/wiki/Amitriptyline | Which medication is preferred for diabetic neuropathy in a patient who has a second-degree atrioventricular block? | Gabapentin |
90 | https://en.wikipedia.org/wiki/Generalized_anxiety_disorder | https://en.wikipedia.org/wiki/Myasthenia_gravis | Which anxiolytic is preferred for generalized anxiety disorder in a patient who has Myasthenia Gravis? | Buspirone |
91 | https://en.wikipedia.org/wiki/Obsessive%E2%80%93compulsive_disorder | https://en.wikipedia.org/wiki/Citalopram | Which medication used in obsessive-compulsive disorder carries a dose-dependent risk of QTc prolongation and should be avoided in patients with cardiac conduction abnormalities? | Citalopram |
92 | https://en.wikipedia.org/wiki/Essential_tremor | https://en.wikipedia.org/wiki/Primidone | Which medication is used as second-line therapy for essential tremor in patients who cannot tolerate propranolol? | Primidone |
93 | https://en.wikipedia.org/wiki/Tuberculosis | https://en.wikipedia.org/wiki/Rifabutin | Which antimycobacterial drug should be replaced in the RIPE regimen for a patient who is HIV-positive and receiving protease inhibitors? | Rifabutin |
94 | https://en.wikipedia.org/wiki/Hyperkalemia | https://en.wikipedia.org/wiki/Sodium_polystyrene_sulfonate | In a patient with hyperkalemia and a history of obstructive bowel disease, which potassium-lowering agent is preferred? | Sodium zirconium cyclosilicate |
95 | https://en.wikipedia.org/wiki/Syphilis | https://en.wikipedia.org/wiki/Doxycycline | In a pregnant patient with primary syphilis and a confirmed penicillin allergy, what is the recommended approach to enable safe treatment? | Penicillin desensitization |
96 | https://en.wikipedia.org/wiki/Chlamydia_infection | https://en.wikipedia.org/wiki/Azithromycin | In a non-pregnant patient with uncomplicated chlamydia who has a documented macrolide allergy precluding azithromycin use, which antibiotic is the preferred alternative? | Doxycycline |
97 | https://en.wikipedia.org/wiki/Cardiac_stress_test | https://en.wikipedia.org/wiki/Chronic_obstructive_pulmonary_disease | In a patient with stable COPD requiring pharmacologic cardiac stress testing, which vasodilator stress agent is preferred to minimize bronchospasm risk? | Regadenoson |
98 | https://en.wikipedia.org/wiki/Warfarin | https://en.wikipedia.org/wiki/Low-molecular-weight_heparin | In a pregnant patient requiring anticoagulation for venous thromboembolism, what is substituted for warfarin? | Low-molecular-weight heparin (LMWH) |
99 | https://en.wikipedia.org/wiki/Tyrosinemia | https://en.wikipedia.org/wiki/Nitisinone | In a patient with tyrosinemia type I on nitisinone therapy, what dietary intervention is mandatory to prevent ocular complications? | Restriction of tyrosine and phenylalanine intake |
100 | https://en.wikipedia.org/wiki/Acute_pancreatitis | https://en.wikipedia.org/wiki/Magnetic_resonance_imaging | In a patient with acute pancreatitis where ultrasound is inconclusive for choledocholithiasis, what non-invasive imaging technique is preferred for evaluating the biliary and pancreatic ducts? | MRCP (Magnetic Resonance Cholangiopancreatography) |
CondMedQA
A diagnostic benchmark of 100 condition-dependent biomedical questions where the correct answer changes based on patient-specific factors such as comorbidities, allergies, pregnancy status, and contraindications.
Dataset Description
Real-world clinical reasoning is inherently conditional: treatment decisions depend on patient-specific factors such as comorbidities, drug allergies, pregnancy, and organ function. Existing biomedical QA benchmarks largely ignore this conditionality, testing only context-free factual recall.
CondMedQA fills this gap with 100 expert-curated questions that require reasoning over two Wikipedia source articles to arrive at a condition-appropriate answer. Each question presents a clinical scenario where the standard-of-care answer is modified by a specific patient condition.
Key Properties
- Domain: Biomedical / clinical pharmacology / diagnostic imaging
- Question type: Short-answer, condition-dependent
- Multi-hop: Every question requires evidence from 2 source articles
- Total questions: 100
- Answer length: Typically 1–5 words
- Split: Test only (diagnostic benchmark)
Dataset Format
A single CSV file (condmedqa.csv) with the following columns:
| Column | Description |
|---|---|
id |
Question identifier (1–100) |
wiki1 |
URL of the first Wikipedia source article (primary condition/disease) |
wiki2 |
URL of the second Wikipedia source article (drug/test/modifier) |
q |
The clinical question with patient-specific conditions |
a |
The condition-appropriate answer |
Usage
from datasets import load_dataset
dataset = load_dataset("jashparekh/CondMedQA")
Or directly:
import pandas as pd
df = pd.read_csv("condmedqa.csv")
Intended Use
- Evaluating LLMs on condition-dependent clinical reasoning
- Benchmarking retrieval-augmented generation (RAG) pipelines on context-sensitive medical QA
- Testing whether models can integrate patient-specific constraints with medical knowledge
- Diagnostic evaluation (100 questions — not intended as a training set)
Citation
@article{parekh2026conditiongated,
title={Condition-Gated Reasoning for Context-Dependent Biomedical Question Answering},
author={Parekh, Jash Rajesh and Kweon, Wonbin and Chan, Joey and Islamaj, Rezarta and Leaman, Robert and Jiang, Pengcheng and Wei, Chih-Hsuan and Wang, Zhizheng and Lu, Zhiyong and Han, Jiawei},
journal={arXiv preprint arXiv:2602.17911},
year={2026}
}
License
MIT
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