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Bayesian Analysis for Inference of an Emerging Epidemic: Citrus Canker in Urban Landscapes Outbreaks of infectious diseases require a rapid response from policy makers. The choice of an adequate level of response relies upon available knowledge of the spatial and temporal parameters governing pathogen spread, affecting...
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Public enemy number one The new coronavirus is no small threat, but we are starting to understand how it works, reports Michael Marshall
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An outbreak of COVID‐19 caused by a new coronavirus: what we know so far
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SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection Autophagy is an essential cellular process affecting virus infections and other diseases and Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated protein 2 (SKP2) as E3 l...
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Virome genomics: a tool for defining the human virome High throughput, deep sequencing assays are powerful tools for gaining insights into virus–host interactions. Sequencing assays can discover novel viruses and describe the genomes of novel and known viruses. Genomic information can predict viral proteins that can be...
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Understanding the emerging coronavirus: what it means for health security and infection prevention
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Protecting the psychological health of children through effective communication about COVID-19
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An evolutionary change in diagnostic virology. The earliest laboratory diagnoses of viral infections were made by microscopy just after the turn of the twentieth century. Animal and egg inoculation were the methods of choice until tissue culture and serology accelerated the field of diagnostic virology during the fifti...
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How the SARS coronavirus causes disease: host or organism? The previous epidemic of severe acute respiratory syndrome (SARS) has ended. However, many questions concerning how the aetiological agent, the novel SARS coronavirus (CoV), causes illness in humans remain unanswered. The pathology of fatal cases of SARS is dom...
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Climate change and infectious disease: time for a new normal?
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Integrated urban services: Experience from four cities on different continents Abstract Rapid urbanization combined with climate change necessitates new types of urban services that make best use of science and technology. The Integrated Urban Hydro-Meteorological, Climate and Environmental Services and systems are a n...
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Contributions of the viral genetic background and a single amino acid substitution in an immunodominant CD8+ T-cell epitope to murine coronavirus neurovirulence. The immunodominant CD8+ T-cell epitope of a highly neurovirulent strain of mouse hepatitis virus (MHV), JHM, is thought to be essential for protection against...
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Insights from the Association of SARS-CoV S-Protein with its Receptor, ACE2
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Scientific Opinion on the welfare of cattle kept for beef production and the welfare in intensive calf farming systems Information given in previous Opinions “Welfare of cattle kept for beef production” (SCAHAW, 2001) and “The risks of poor welfare in intensive calf farming systems” (EFSA, 2006) is updated and recent s...
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Managing business relationships during a pandemic: Conducting a relationship audit and developing a path forward Abstract During stable times, firms will generally aim to create reliable B2B relationships that provide increased efficiency and profitability. However, tumultuous times, such as the time during a major pan...
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Genetic diversity and evolution of SARS-CoV-2 Abstract COVID-19 is a viral respiratory illness caused by a new coronavirus called SARS-CoV-2. The World Health Organization declared the SARS-CoV-2 outbreak a global public health emergency. We performed genetic analyses of eighty-six complete or near-complete genomes of ...
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Émergences et barrières d’espèces Résumé Les infections virales émergentes sont définies ici comme celles dont l’incidence a augmenté les 20 dernières années. Ces infections concernent l’homme, mais aussi les viroses animales, touchant les animaux domestiques ou sauvages. Pour l’homme, les émergences virales sont d’ori...
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Emergency Preparedness—Planning and Management In general, emergencies can be divided into internal and external situations. Regardless of the nature of the emergency, the organizational response will be quite different when the emergency condition exists within the facility from when it occurs at some distant location...
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How the SARS vaccine effort can learn from HIV—speeding towards the future, learning from the past A remarkable collaborative effort coordinated by the severe acute respiratory syndrome (SARS) team at WHO resulted in discovery of the etiologic agent of severe acute respiratory syndrome less than 2 months after the anno...
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Chapter 6 Ecoepidemiology of Alphaviruses and Flaviviruses Abstract Within the ecosystems, the balance is important since the populations maintain their size and the food habits that are constant over time; in contrast, the disappearance of natural sources or the alteration of habitat at different levels can cause majo...
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A double epidemic model for the SARS propagation BACKGROUND: An epidemic of a Severe Acute Respiratory Syndrome (SARS) caused by a new coronavirus has spread from the Guangdong province to the rest of China and to the world, with a puzzling contagion behavior. It is important both for predicting the future of the prese...
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Caution on Kidney Dysfunctions of COVID-19 Patients Summary Background: To date, large amounts of epidemiological and case study data have been available for the Coronavirus Disease 2019 (COVID-19), which suggested that the mortality was related to not just respiratory complications. Here, we specifically analyzed kidn...
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A large and accurate collection of peptidase cleavages in the MEROPS database Peptidases are enzymes that hydrolyse peptide bonds in proteins and peptides. Peptidases are important in pathological conditions such as Alzheimer's disease, tumour and parasite invasion, and for processing viral polyproteins. The MEROPS dat...
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Synchronized shift of oral, faecal and urinary microbiotas in bats and natural infection dynamics during seasonal reproduction Seasonal reproduction is a period of extreme physiological and behavioural changes, yet we know little about how it may affect host microbial communities (i.e. microbiota) and pathogen transmis...
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Diseases of the Liver and Hepatobiliary System
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Zoonotic disease risk perceptions in the British veterinary profession Abstract In human and veterinary medicine, reducing the risk of occupationally-acquired infections relies on effective infection prevention and control practices (IPCs). In veterinary medicine, zoonoses present a risk to practitioners, yet little is...
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Adaptive human behavior in epidemiological models. The science and management of infectious disease are entering a new stage. Increasingly public policy to manage epidemics focuses on motivating people, through social distancing policies, to alter their behavior to reduce contacts and reduce public disease risk. Person...
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Ethics and Terror Medicine The field of medicine has long been defined not only by diagnostic and treatment techniques but also by standards of behavior. The Hippocratic Oath was introduced about the same time as the concept of case histories and prognosis, in ancient Greece, fifth century BCE. Despite vast changes in ...
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Pathogen seasonality and links with weather in England and Wales: a big data time series analysis BACKGROUND: Many infectious diseases of public health importance display annual seasonal patterns in their incidence. We aimed to systematically document the seasonality of several human infectious disease pathogens in Eng...
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; previously provisionally named 2019 novel coronavirus or 2019-nCoV) disease (COVID-19) in China at the end o...
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Cytokine systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates BACKGROUND: The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic and pathogenic potential of emerging coronaviruse...
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Work-related Covid-19 transmission Importance: Our study helps fill the knowledge gap related to work-related transmission in the emerging coronaviral pandemic. Objective: To demonstrate high-risk occupations for early coronavirus disease 2019 (Covid-19) local transmission. Methods: In this observational study, we extr...
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Epitope-based chimeric peptide vaccine design against S, M and E proteins of SARS-CoV-2 etiologic agent of global pandemic COVID-19: an in silico approach Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing pandemic of coronavirus disease 2019 (COVID-19), a public health emergency o...
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Estimating excess 1- year mortality from COVID-19 according to underlying conditions and age in England: a rapid analysis using NHS health records in 3.8 million adults RAPID COMMUNICATION 22 March 2020 Estimating excess 1- year mortality from COVID-19 according to underlying conditions and age in England: a rapid anal...
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Climate Change and Health in Canada
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Climate Change and Human Health Impacts in the United States: An Update on the Results of the U.S. National Assessment The health sector component of the first U.S. National Assessment, published in 2000, synthesized the anticipated health impacts of climate variability and change for five categories of health outcomes...
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An oncologist perspective on COVID 19: A mysterious cryptic virus
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Ecology of Neglected Rodent-Borne American Orthohantaviruses The number of documented American orthohantaviruses has increased significantly over recent decades, but most fundamental research has remained focused on just two of them: Andes virus (ANDV) and Sin Nombre virus (SNV). The majority of American orthohantaviru...
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COVID-19: time for paradigm shift in the nexus between local, national and global health
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Modeling Disease Spread at Global Mass Gatherings: Data Requirements and Challenges Spread of infectious diseases at global mass gatherings can pose health threats to both the hosting country and the countries where participants originate. The travel patterns at the end of these international events may result in epide...
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Do Face Masks Create a False Sense of Security? A COVID-19 Dilemma Face masks have become an emblem of the public response to COVID-19, with many governments mandating their use in public spaces. The logic is that face masks are low cost and might help prevent some transmission. However, from the start, the assumption ...
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Provider Burnout and Fatigue During the COVID-19 Pandemic: Lessons Learned From a High-Volume Intensive Care Unit
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Seasonal Fluctuations of Astrovirus, But Not Coronavirus Shedding in Bats Inhabiting Human-Modified Tropical Forests Emerging infectious diseases (EIDs) are considered a major threat to global health. Most EIDs appear to result from increased contact between wildlife and humans, especially when humans encroach into for...
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Intrinsic resistance of feline peritoneal macrophages to coronavirus infection correlates with in vivo virulence. Cats infected with virulent feline coronavirus strains develop feline infectious peritonitis, an invariably fatal, immunologically mediated disease; avirulent strains cause either clinically inapparent infe...
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response Abstract Background and aim As a result of its rapid spread in various countries around the world, on March 11, 2020, WHO issued an announcement of the change in coronavirus disease 2019 status from epidemic t...
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El síndrome respiratorio agudo grave: primera pandemia del siglo XXI
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Reasoning of spike glycoproteins being more vulnerable to mutations among 158 coronavirus proteins from different species In this study, we used the probabilistic models developed by us over the last several years to analyze 158 proteins from coronaviruses in order to determine which protein is more vulnerable to mutat...
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Metronomic oral vinorelbine and lung cancer therapy during the COVID 19 pandemic: a single-center experience • Intravenous vinorelbine is a standard treatment for advanced NSCLC; • Oral vinorelbine is equally effective as compared to intravenous vinorelbine; • Metronomic oral formulation of vinorelbine is a safe and ac...
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Deep Learning Assisted Memetic Algorithm for Shortest Route Problems Finding the shortest route between a pair of origin and destination is known to be a crucial and challenging task in intelligent transportation systems. Current methods assume fixed travel time between any pairs, thus the efficiency of these approache...
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Rhinovirus-Induced Exacerbations of Asthma and COPD Over the past two decades, increasing evidence has shown that, in patients with chronic airways disease, viral infection is the most common cause of exacerbation. This review will examine the evidence for viral-induced exacerbations of asthma and chronic obstructive l...
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Chapter 2 Syndromic surveillance using web data: a systematic review Abstract During the recent years, a lot of debate is taken place about the evolution of Smart Healthcare systems. Particularly, how these systems can help people improve human conditions of health, by taking advantages of the new Information and Commu...
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Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants † Abstract The recent outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 in December 2019 raised global health concerns. The viral 3-chymotrypsin-like cysteine protease (3CLpro) enzyme controls coronavirus rep...
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Prediction of New Coronavirus Infection Based on a Modified SEIR Model BACKGROUND The outbreak of the new coronavirus infection in Wuhan City, Hubei Province in December 2019, poses a huge threat to China and even global public health security. Respiratory droplets and contact transmission are the main routes of transm...
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Disease ecology and the global emergence of zoonotic pathogens The incidence and frequency of epidemic transmission of zoonotic diseases, both known and newly recognized, has increased dramatically in the past 30 years. It is thought that this dramatic disease emergence is primarily the result of the social, demographi...
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Large-scale evolutionary surveillance of the 2009 H1N1 influenza A virus using resequencing arrays In April 2009, a new influenza A (H1N1 2009) virus emerged that rapidly spread around the world. While current variants of this virus have caused widespread disease, particularly in vulnerable groups, there remains the po...
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A review on microbial contaminants in stormwater runoff and outfalls: Potential health risks and mitigation strategies Abstract Demands on global water supplies are increasing in response to the need to provide more food, water, and energy for a rapidly growing population. These water stressors are exacerbated by clima...
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Outdoor environments and human pathogens in air Are pathogens in outdoor air a health issue at present or will they become a problem in the future? A working group called AirPath - Outdoor Environments and Human Pathogens in Air was set up in 2007 at University College London, UK with the aim of opening new discussion ...
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Medical mask versus cotton mask for preventing respiratory droplet transmission in micro environments Abstract The objective of this study was to investigate whether cotton mask worn by respiratory infection person could suppress respiratory droplet levels compared to medical mask. We recruited adult volunteers with co...
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Circulating influenza virus, climatic factors, and acute myocardial infarction: a time series study in England and Wales and Hong Kong. BACKGROUND Previous studies identifying associations between influenza and acute cardiac events may have been confounded by climatic factors. Differing seasonal patterns of influenza a...
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Redesigning a large school-based clinical trial in response to changes in community practice Background Asthma exacerbations are seasonal with the greatest risk in elementary-age students occurring shortly after returning to school following summer break. Recent research suggests that this seasonality in children is pr...
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Events postponed or cancelled because of the coronavirus outbreak A number of events that cover developments in sealing technology and related products have been postponed, or even cancelled, in response to the rapidly changing circumstances associated with the coronavirus (COVID-19) outbreak.
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Understanding SARS-CoV-2: Genetic Diversity, Transmission and Cure in Human As the SARS-CoV-2 virus race around the world across the different population, there needs to be a consolidated effort to understand the divergence of demographically distributed strains. The emerging trends in SARS-CoV-2 genome data show speci...
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Removal of atmospheric CO2 by rock weathering holds promise for mitigating climate change.
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Molecular Interactions in the Assembly of Coronaviruses Publisher Summary This chapter describes the interactions between the different structural components of the viruses and discusses their relevance for the process of virion formation. Two key factors determine the efficiency of the assembly process: intracellular ...
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Global rheumatology in the time of COVID-19
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Viral respiratory disease in pregnancy. PURPOSE OF REVIEW Recently there has been an increased concern over viral respiratory infections and their potential for a pandemic. This concern makes it important to review the most current guidelines for the management of viral respiratory diseases in pregnancy. RECENT FINDING...
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Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop The 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) originally arose as part of a major outbreak of respiratory disease centered on Hubei province, China. It is now a gl...
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Psychological responses, behavioral changes and public perceptions during the early phase of the COVID-19 outbreak in China: a population based cross-sectional survey Objective: To investigate psychological and behavioral responses to the threat of SARS-CoV-2 infections and their associations with public perceptions in...
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Timely mental health care for the 2019 novel coronavirus outbreak is urgently needed
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Changes in epithelial secretory cells and potentiation of neurogenic inflammation in the trachea of rats with respiratory tract infections In rats respiratory tract infections due to Sendai virus and coronavirus usually are transient, but they can have long-lasting consequences when accompanied by Mycoplasma pulmonis i...
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Why does the coronavirus spread so easily between people?
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Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design As the SARS-CoV-2 pandemic is rapidly progressing, the need for the development of an effective vaccine is critical. A promising approach for vaccine development is to generate, through codon pair deoptimization, an attenuated virus. T...
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Assessing the plausibility of subcritical transmission of 2019-nCoV in the United States Abstract: The 2019-nCoV outbreak has raised concern of global spread. While person-to-person transmission within the Wuhan district has led to a large outbreak, the transmission potential outside of the region remains unclear. Here...
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Coronavirus Endoribonuclease Activity in Porcine Epidemic Diarrhea Virus Suppresses Type I and Type III Interferon Responses Identifying viral antagonists of innate immunity and determining if they contribute to pathogenesis are critical for developing effective strategies to control emerging viruses. Previously, we re...
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Coronavirus Perceptions And Economic Anxiety We provide one of the first systematic assessments of the development and determinants of economic anxiety at the onset of the coronavirus pandemic. Using a global dataset on internet searches and two representative surveys from the US, we document a substantial increase in ...
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Review on Machine and Deep Learning Models for the Detection and Prediction of Coronavirus The novel Coronavirus disease has increased rapidly in the Wuhan city of China in December 2019. This fatal virus has spread across the whole world like a fire in different stages and affecting millions of population and thousand...
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Severe weather warnings predict fracture epidemics Abstract Winter epidemics of fractures have been described that greatly exceed normal seasonal variations and overwhelm resources. We investigated the relationship between severe weather warnings, the frequency of fractures, and fracture related workload. There was a s...
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SARS-CoV-2 mortality in blacks and temperature-sensitivity to an angiotensin-2 receptor blocker Tropical climates provoke adaptations in skin pigmentation and in mechanisms controlling the volume, salt-content and pressure of body fluids. For many whose distant ancestors moved to temperate climes, these adaptations pro...
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Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is an imminent ne...
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Design of Wide-Spectrum Inhibitors Targeting Coronavirus Main Proteases The genus Coronavirus contains about 25 species of coronaviruses (CoVs), which are important pathogens causing highly prevalent diseases and often severe or fatal in humans and animals. No licensed specific drugs are available to prevent their infe...
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SARS-CoV-2 is sensitive to type I interferon pretreatment. SARS-CoV-2, a novel coronavirus (CoV), has recently emerged causing an ongoing outbreak of viral pneumonia around the world. While genetically distinct from the original SARS-CoV, both group 2B CoVs share similar genome organization and origins to coronaviruses...
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Effectiveness of airport screening at detecting travellers infected with 2019-nCoV As the number of novel coronavirus cases grows both inside and outside of China, public health authorities require evidence on the effectiveness of control measures such as thermal screening of arrivals at airports. We evaluated the effe...
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COVID-19 lockdowns cause global air pollution declines with implications for public health risk The lockdown response to COVID-19 has caused an unprecedented reduction in global economic activity. We test the hypothesis that this has reduced tropospheric and ground-level air pollution concentrations using satellite dat...
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Mitigating the air pollution effect? The remarkable decline in the pollution-mortality relationship in Hong Kong Abstract Using transboundary pollution from mainland China as an instrument, we show that air pollution leads to higher cardio-respiratory mortality in Hong Kong. However, the air pollution effect has dramat...
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Differential Diagnosis of Common Acute Toxicologic Versus Nontoxicologic Illness This table outlines common toxicologic versus nontoxicologic rule outs based on clinical abnormalities seen in an acutely ill animal. The purpose is to provide an initial guideline for considering toxicologic versus nontoxicologic rule out...
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First two months of the 2019 Coronavirus Disease (COVID-19) epidemic in China: real-time surveillance and evaluation with a second derivative model BACKGROUND: Similar to outbreaks of many other infectious diseases, success in controlling the novel 2019 coronavirus infection requires a timely and accurate monitoring of...
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Cold Exposure-Induced Up-Regulation of Hsp70 Positively Regulates PEDV mRNA Synthesis and Protein Expression In Vitro Porcine epidemic diarrhea (PED) is a highly contagious, intestinal infectious disease caused by porcine epidemic diarrhea virus (PEDV). PEDV as an emerging and re-emerging epizootic virus of swine cause...
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Post-translational modifications of coronavirus proteins: roles and function Post-translational modifications (PTMs) refer to the covalent modifications of polypeptides after they are synthesized, adding temporal and spatial regulation to modulate protein functions. Being obligate intracellular parasites, viruses rely ...
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Participants – Multilateral Organizations and International Financial Institutions Multilateral organizations are composed of sovereign governments. They may be regional, organized around a common issue or function, or global. International financial institutions (IFIs) are international banks composed of sovereign mem...
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Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study BACKGROUND: A range of public health measures have been implemented to suppress local transmission of coronavirus disease 2019 (COVID-19) in Hong Kong. We examined the effect of thes...
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Systematic Identification of Novel, Essential Host Genes Affecting Bromovirus RNA Replication Positive-strand RNA virus replication involves viral proteins and cellular proteins at nearly every replication step. Brome mosaic virus (BMV) is a well-established model for dissecting virus-host interactions and is one of ve...
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39yvniki
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Short Term Effects of Weather on Hand, Foot and Mouth Disease BACKGROUND: Hand, foot, and mouth disease (HFMD) outbreaks leading to clinical and fatal complications have increased since late 1990s; especially in the Asia Pacific Region. Outbreaks of HFMD peaks in the warmer season of the year, but the underlying factor...
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3ahp9tli
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Understanding Human Coronavirus HCoV-NL63 Even though coronavirus infection of humans is not normally associated with severe diseases, the identification of the coronavirus responsible for the outbreak of severe acute respiratory syndrome showed that highly pathogenic coronaviruses can enter the human population. Short...
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Frailty and Seasonality
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Single organelle analysis to characterize mitochondrial function and crosstalk during viral infection Mitochondria are key for cellular metabolism and signalling processes during viral infection. We report a methodology to analyse mitochondrial properties at the single-organelle level during viral infection using a rec...
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Estimation of basic reproduction number of the Middle East respiratory syndrome coronavirus (MERS-CoV) during the outbreak in South Korea, 2015 BACKGROUND: In South Korea, an outbreak of Middle East respiratory syndrome (MERS) occurred in 2015. It was the second largest MERS outbreak. As a result of the outbreak in Sou...
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SARS-CoV and SARS-CoV-2 main protease residue interaction networks change when bound to inhibitor N3 COVID-19 is a respiratory disease caused by the coronavirus SARS-CoV-2. SARS-CoV-2 has many similarities with SARS-CoV. Both viruses rely on a protease called the main protease, or M(pro), for replication. Therefore, in...
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Building resilience against biological hazards and pandemics: COVID-19 and its implications for the Sendai Framework Abstract 2020 has become the year of coping with COVID-19. This year was to be the “super year” for sustainability, a year of strengthening global actions to accelerate the transformations required for a...
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Association of COVID-19 Infections in San Francisco in Early March 2020 with Travel to New York and Europe Real-time dissemination of epidemiological survey data from positive COVID-19 cases is critical to support efforts to contain or reduce spread of viral infection in the community. Here we detected a significant as...
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Retinal pathology in multiple sclerosis: insight into the mechanisms of neuronal pathology
how does the coronavirus respond to changes in the weather
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