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Superficial cultures in neonatal sepsis evaluations. Impact on antibiotic decision making. The authors performed a retrospective analysis of neonatal superficial cultures and their effect on antimicrobial decision making during a nine-month period at Nashville General Hospital. They obtained and reviewed charts of in...
0Bacterial Infections and Mycoses
Catheter-related sepsis: prospective, randomized study of three methods of long-term catheter maintenance. We studied the infectious risk of different methods of managing vascular catheters during long-term use. Consecutive surgical ICU patients requiring triple lumen catheters, pulmonary artery catheters, or arteria...
0Bacterial Infections and Mycoses
Effect of blood transfusion on oxygen consumption in pediatric septic shock. Treatment plans for pediatric septic shock advocate increasing oxygen consumption (VO2). Recent studies in septic shock indicate that improving oxygen delivery (DO2) by increasing blood flow will increase VO2. We prospectively examined the ...
0Bacterial Infections and Mycoses
Effects of epinephrine on hemodynamics and oxygen metabolism in dopamine-resistant septic shock. The hemodynamic effects of epinephrine were prospectively studied in 13 patients with septic shock who remained hypotensive after both fluid loading and dopamine. Hemodynamic measurements were performed before and one hou...
0Bacterial Infections and Mycoses
Denatured muscle grafts for nerve repair. An experimental model of nerve damage in leprosy About 20% of patients with leprosy develop localised granulomatous lesions in peripheral nerves. We report experiments in guinea-pigs in which freeze-thawed autogenous muscle grafts were used for the treatment of such mycobact...
0Bacterial Infections and Mycoses
Selection of antibiotic coverage in vascular patients undergoing cystoscopy. Bacteremic seeding of prosthetic vascular grafts represents a cause for graft infection; transurethral procedures account for one source of bacteremia. Therefore, a prospective study of 200 patients undergoing cystoscopy was conducted to ide...
0Bacterial Infections and Mycoses
Possible role of bacterial siderophores in inflammation. Iron bound to the Pseudomonas siderophore pyochelin can function as a hydroxyl radical catalyst. Tissue injury has been linked to neutrophil associated hydroxyl radical (.OH) generation, a process that requires an exogenous transition metal catalyst such as iron...
0Bacterial Infections and Mycoses
Treatment of fungal skin infections: state of the art. The number of cases of mycotic infections are increasing, presenting physicians today with an unprecedented challenge in handling the treatment and prophylactic control of these disorders. The increase in mycotic disorders is due to many factors, such as longer l...
0Bacterial Infections and Mycoses
Itraconazole in tinea versicolor: a review. Itraconazole, a new orally active triazole antifungal, has been tested in patients with pityriasis versicolor. A number of studies have shown that itraconazole is effective for this mild fungal skin disease. The total dose required for effective treatment is 1000 mg, and i...
0Bacterial Infections and Mycoses
Itraconazole in common dermatophyte infections of the skin: fixed treatment schedules. Itraconazole is an effective medication against the most common dermatophytoses. It has been shown to be more active than griseofulvin and ketoconazole. Ease of use, affinity for keratinized tissues, lack of toxicity, continued ac...
0Bacterial Infections and Mycoses
Treatment of oral candidosis with itraconazole: a review. Oral candidosis is a common infection in infants, elderly persons, patients receiving immunosuppressive therapy, and patients with acquired immunodeficiency syndrome (AIDS). The orally active antifungal agent itraconazole has been evaluated in a number of diff...
0Bacterial Infections and Mycoses
Individualizing treatment of vaginal candidiasis. Clinicians have a vast array of effective antimycotics for the treatment of vaginal candidiasis. Multiple topical formulations are available, yet there is little evidence to suggest that formulation per se influences outcome. A growing number of highly effective oral...
0Bacterial Infections and Mycoses
Itraconazole treatment of phaeohyphomycosis. Nineteen patients with phaeohyphomycosis were treated with itraconazole. Of these, 17 were assessable for clinical outcome. Of these, two had received no prior therapy, five had failed amphotericin B therapy, four had failed ketoconazole or miconazole therapy, and five ha...
0Bacterial Infections and Mycoses
Clostridium difficile invasion and toxin circulation in fatal pediatric pseudomembranous colitis. The direct involvement of Clostridium difficile in the lesional tissue of pseudomembranous colitis has not been demonstrated; the organism's effects have been assumed to be strictly toxin mediated. Because C. difficile ...
0Bacterial Infections and Mycoses
Cerebrospinal fluid changes after 48 hours of effective therapy for Hemophilus influenzae type B meningitis. Interval cerebrospinal fluid (CSF) analysis is often performed to assess efficacy of treatment for bacterial meningitis. The authors reviewed 101 cases of pediatric bacterial meningitis resulting from Hemophil...
0Bacterial Infections and Mycoses
Streptococcus mitis sepsis in bone marrow transplant patients receiving oral antimicrobial prophylaxis. PURPOSE: Streptococcal infection has increasingly become a problem in neutropenic patients. We report on an outbreak of Streptococcus mitis sepsis in six bone marrow transplant patients receiving oral antimicrobial...
0Bacterial Infections and Mycoses
Intraamniotic infection in the very early phase of the second trimester. A total of 157 consecutive patients were studied in an effort to examine prospectively the incidence of asymptomatic intraamniotic infection in the early phase of the second trimester. All patients were referred for amniotic fluid karyotyping. ...
0Bacterial Infections and Mycoses
hemofiltration reverses left ventricular dysfunction during sepsis in dogs. Depressed left ventricular (LV) contractility in sepsis has been ascribed to the presence of circulating cardiodepressant substance (filterable cardiodepressant factor in sepsis [FCS]); however, this finding is controversial. The authors hypo...
0Bacterial Infections and Mycoses
Ceftazidime/clindamycin versus tobramycin/clindamycin in the treatment of intra-abdominal infections. In order to assess the efficacy and toxicity of ceftazidime as a substitute for aminoglycosides in the treatment of intra-abdominal sepsis, a prospective randomized trial was conducted. Ninety-four patients (49% trau...
0Bacterial Infections and Mycoses
Effects of method of hemostasis on wound-infection rate. Adequate hemostasis is important in preventing postoperative wound infection. This study compared four methods of hemostasis: specific pinpoint vessel electrocautery (SPC), specific vessel ligation with 4-0 vicryl (SVL), nonspecific electrocautery of vessel plu...
0Bacterial Infections and Mycoses
Congenital insensitivity to pain with neuroparalytic keratitis. Congenital insensitivity to pain is a well-defined entity in the group of sensory deficiency syndromes. To the best of our knowledge, unilateral neuroparalytic keratitis associated with congenital insensitivity to pain has not been reported. We report s...
0Bacterial Infections and Mycoses
In vitro evaluation of nicotinamide riboside analogs against Haemophilus influenzae. Exogenous NAD, nicotinamide mononucleotide, or nicotinamide riboside is required for the growth of Haemophilus influenzae. These compounds have been defined as the V-factor growth requirement. We have previously shown that the inter...
0Bacterial Infections and Mycoses
Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers. beta-Lactamase production (nitrocefin disk method) and aga...
0Bacterial Infections and Mycoses
Activity of compound G2 isolated from alfalfa roots in experimental dermatophyte infection. Compound G2 isolated from alfalfa roots was applied topically to skin lesions of guinea pigs experimentally infected with the dermatophyte Trichophyton mentagrophytes var. granulare. After 12 to 15 applications, 80% of the in...
0Bacterial Infections and Mycoses
In vitro susceptibility of Xanthomonas (Pseudomonas) maltophilia to newer antimicrobial agents. The susceptibilities of 45 clinical and 3 environmental isolates of Xanthomonas maltophilia to 14 antimicrobial agents was determined by broth microdilution. The newer quinolones PD117596, PD117558, PD127391, A-56620, amif...
0Bacterial Infections and Mycoses
Comparison of cilofungin and amphotericin B for therapy of murine candidiasis. We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis. Three different dosages of each drug plus controls were evaluated. Statistically improved survival was noted only among m...
0Bacterial Infections and Mycoses
Emergence of ciprofloxacin resistance in nosocomial methicillin-resistant Staphylococcus aureus isolates. Resistance during ciprofloxacin plus rifampin therapy for methicillin-resistant S aureus colonization. We initiated a randomized, single-blinded trial of ciprofloxacin plus rifampin vs sulfamethoxazole and trimeth...
0Bacterial Infections and Mycoses
Buccal cellulitis. Buccal cellulitis (BC) is an innocuous appearing infection of the cheek that is found in children and has a high incidence of concomitant bacteremia. Typically, the child is younger than 12 months and has a 2 to 8 hour prodrome of coryza and fever before developing the cellulitis on the cheek. A p...
0Bacterial Infections and Mycoses
Intraocular pressure changes and postural changes of intraocular pressure in experimentally induced Hansen's disease of rhesus, mangabey, and African green monkeys. In our long term evaluation of patients with Hansen's disease we have frequently found reduction of their intraocular pressure. Furthermore, we noted cha...
0Bacterial Infections and Mycoses
Seven-day administration of recombinant human granulocyte colony-stimulating factor to newborn rats: modulation of neonatal neutrophilia, myelopoiesis, and group B Streptococcus sepsis. Single-pulse administration of rhG-colony-stimulating factor (CSF) to neonatal rats was previously demonstrated to induce peripheral ...
0Bacterial Infections and Mycoses
Ringer's acetate and dextran-70 with or without hypertonic saline in endotoxin-induced shock in pigs. The effects of Ringer's acetate, 6% dextran-70, 7.5% NaCl, and the combination of 7.5% NaCl and dextran-70 were tested in resuscitation from endotoxin shock induced by continuous iv infusion of Escherichia coli endoto...
0Bacterial Infections and Mycoses
Infection control in the nursing home: the physician's role. Infection control in the nursing home or long-term care facility is an increasingly complex activity. The high rates (approximately 15%) and special risks (group activities, crowding) for nosocomial infection demand special attention by attending physicians...
0Bacterial Infections and Mycoses
Use of latex agglutination technique for detecting Legionella pneumophila (serogroup 1) antibodies. Following the outbreak of Legionnaires' disease in Stafford in 1985, 500 serum samples were submitted to the indirect immunofluorescence antibody test and a latex agglutination. Latex agglutination using ultrasonically...
0Bacterial Infections and Mycoses
History of antifungals. Until two to three decades ago, only a few drugs were available for the treatment of fungal infections. The status of antifungal therapy changed dramatically in the late 1960s with the introduction of newer broader spectrum agents, such as the iodinated trichlorophenols and the imidazoles, tha...
0Bacterial Infections and Mycoses
A clinical trial of topical terbinafine (a new allylamine antifungal) in the treatment of tinea pedis. Twenty-three patients were enrolled in a randomized, double-blind trial of terbinafine 1% cream compared with placebo vehicle in the treatment of tinea pedis. Of the 20 patients who were evaluated for efficacy, 10 r...
0Bacterial Infections and Mycoses
Efficacy and tolerability of topical terbinafine in the treatment of tinea cruris. Thirty men with clinical and mycologic evidence of tinea cruris were enrolled in a controlled, randomized, double-blind trial comparing terbinafine 1% cream and its cream vehicle as placebo. Patients applied the test medications to the...
0Bacterial Infections and Mycoses
Treatment of tinea cruris with topical terbinafine. Twenty-three patients were enrolled in a randomized, double-blind trial of terbinafine 1% cream versus its vehicle (placebo) in the treatment of tinea cruris. One patient had a negative initial culture and was excluded, and two patients were dropouts, one because of...
0Bacterial Infections and Mycoses
Oral terbinafine versus griseofulvin in the treatment of moccasin-type tinea pedis. The safety and effectiveness of oral terbinafine, 125 mg twice daily, and griseofulvin, 250 mg twice daily, in patients with moccasin-type tinea pedis were examined in a double-blind randomized trial. At the end of the 6-week treatmen...
0Bacterial Infections and Mycoses
Leprotic involvement of peripheral nerves in the absence of skin lesions. Case report and literature review. In the absence of clinically apparent cutaneous lesions, primarily neural leprosy is uncommon. Primarily neural leprosy presents clinically as a peripheral neuropathy that most frequently affects motor nerves ...
0Bacterial Infections and Mycoses
Bioaerosols: prevalence and health effects in the indoor environment. Assessing the role of bioaerosols in residence-related symptoms involves (1) determining that symptoms are related to the residence by medical examination and careful questioning, (2) connecting reported symptoms with known or hypothesized effects o...
0Bacterial Infections and Mycoses
Monoclonal antibody to mouse lipopolysaccharide receptor protects mice against the lethal effects of endotoxin. Specific endotoxic lipopolysaccharide (LPS) binding sites on the cell membranes of murine lymphocytes and macrophages that may serve as functional receptors for LPS have recently been identified using photoa...
0Bacterial Infections and Mycoses
Platelet-activating factor or a platelet-activating factor antagonist decreases tumor necrosis factor-alpha in the plasma of mice treated with endotoxin. When L-platelet-activating factor (PAF) or alprazolam (a PAF antagonist) was administered to lipopolysaccharide (LPS)-treated mice, the level of plasma tumor necrosi...
0Bacterial Infections and Mycoses
Protective effects of polyclonal sera and of monoclonal antibodies active to Salmonella minnesota Re595 lipopolysaccharide during experimental endotoxemia. Mice were passively immunized with sera from blood donors active for rough lipopolysaccharides (LPS), the J5 (Rc chemotype) mutant of Escherichia coli O111:B4, and...
0Bacterial Infections and Mycoses
Antimicrobial resistance of Shigella isolates in the USA: the importance of international travelers. A nationwide sample of Shigella isolates was collected and tested for resistance to 12 antimicrobial agents to assess the prevalence and epidemiologic correlates of antimicrobial resistance in Shigella. Of the isolate...
0Bacterial Infections and Mycoses
Cefuroxime treatment failure of nontypable Haemophilus influenzae meningitis associated with alteration of penicillin-binding proteins. A 10-year-old boy presented with nuchal rigidity and cerebrospinal fluid (CSF) leukocytosis initially and again on day 6 of intravenous cefuroxime therapy (200 mg/kg/day). Both CSF s...
0Bacterial Infections and Mycoses
Restriction endonuclease analysis of total cellular DNA of Aspergillus fumigatus isolates of geographically and epidemiologically diverse origin. No typing system exists for Aspergillus fumigatus, though isolates are distinguishable by phenotypic characteristics. DNA was prepared by lysis of protoplasts, followed by ...
0Bacterial Infections and Mycoses
Detection of interleukin-3 in the serum of mice infected with Mycobacterium lepraemurium. Infection of mice by Mycobacterium lepraemurium is accompanied by ablation of erythropoiesis in the bone marrow and gross enlargement of the spleen. This, together with increased monocytopoiesis and the earlier demonstration of ...
0Bacterial Infections and Mycoses
A large outbreak of antibiotic-resistant shigellosis at a mass gathering. In July 1987, a large outbreak of shigellosis occurred among attendees at a mass gathering in a national forest, the annual Rainbow Family Gathering. Sanitation in the campsite was poor, allowing widespread transmission of disease, probably by ...
0Bacterial Infections and Mycoses
Prevalence and diagnosis of Legionella pneumonia: a 3-year prospective study with emphasis on application of urinary antigen detection. During a 3-year period the frequency of legionellosis in hospitalized patients with community-acquired and nosocomial pneumonias was 3.4% (23/684 cases) and 5.9% (33/559), respectivel...
0Bacterial Infections and Mycoses
Tumor necrosis factor-alpha plays a role in host defense against Histoplasma capsulatum. Tumor necrosis factor-alpha was detected in supernatants collected from BALB/c mouse peritoneal macrophages incubated continuously with Histoplasma capsulatum. The levels of TNF alpha measured by actinomycin D bioassay peaked wit...
0Bacterial Infections and Mycoses
Occurrence of secondary attenuating mutations in avirulent Salmonella typhimurium vaccine strains. The attenuating delta aroA554 mutation in Salmonella typhimurium strain SL3261 was complemented in vitro by selecting for AroA+ recombinant DNA clones. SL3261 containing cloned aroA+ genes did not require exogenous phen...
0Bacterial Infections and Mycoses
Nasal carriage of Staphylococcus aureus: correlation with hormonal status in women. In view of recent observations on hormone-microorganism interactions, a study of Staphylococcus aureus nasal carriage in relation to sex-hormone status was undertaken. Prospectively in 479 women attending a colpocytologic clinic, horm...
0Bacterial Infections and Mycoses
Positive Lyme serology in subacute bacterial endocarditis. A study of four patients. Lyme borreliosis is a multisystem inflammatory disorder caused by the tick-borne spirochete Borrelia burgdorferi. Clinical manifestations are protean, involving the skin, joints, peripheral and central nervous systems, and the heart....
0Bacterial Infections and Mycoses
Changing epidemiology of group A streptococcal infection in the USA. To see whether changes in the epidemiology of group A streptococcal disease in the USA have been accompanied by a corresponding change in serotype distribution, epidemiological and M-typing and T-typing data for 5193 strains sent to the Centers for D...
0Bacterial Infections and Mycoses
A randomized, prospective field trial of a conjugate vaccine in the protection of infants and young children against invasive Haemophilus influenzae type b disease BACKGROUND. Haemophilus influenzae type b is the leading cause of invasive bacterial disease in young children. The capsular polysaccharide vaccine does...
0Bacterial Infections and Mycoses
Limited efficacy of a Haemophilus influenzae type b conjugate vaccine in Alaska Native infants. The Alaska H. influenzae Vaccine Study Group BACKGROUND. The prevention of invasive Haemophilus influenzae type b disease requires a vaccine that is effective when administered during the first six months of life. The in...
0Bacterial Infections and Mycoses
The use of prophylactic furazolidone to control a nosocomial epidemic of multiply resistant Salmonella typhimurium in pediatric wards. The nosocomial spread of enteric pathogens is often difficult to control in overcrowded pediatric wards. During 1983 and 1984, despite cohorting of patients and enforced hand washing,...
0Bacterial Infections and Mycoses
Safety evaluation of PRP-D Haemophilus influenzae type b conjugate vaccine in children immunized at 18 months of age and older: follow-up study of 30,000 children. We evaluated the safety of the PRP-D conjugate Hib vaccine (ProHIBit, Connaught) in 29,309 children vaccinated at 18-60 months of age in the Southern Calif...
0Bacterial Infections and Mycoses
Immunogenicity of Haemophilus b conjugate vaccine (meningococcal protein conjugate) in children with prior invasive Haemophilus influenzae type b disease. Children younger than 2 years of age with previous invasive Haemophilus influenzae (Hib) type b disease may not develop protective antibodies to antigens of Hib and...
0Bacterial Infections and Mycoses
Mycoplasmal pneumonia. Are you thinking of atypical presentations? The presentations of mycoplasmal pneumonia can be varied and sometimes complicated. The atypical nature of this illness, as opposed to the clear pattern of findings in classic bacterial pneumonias, leads the physician to the diagnosis. Appropriate th...
0Bacterial Infections and Mycoses
Early postoperative care of the cardiac transplantation patient: routine considerations and immunosuppressive therapy. The authors have attempted to outline the current state of the art with respect to the early postoperative management of the cardiac transplant recipient with special attention to immunosuppressive th...
0Bacterial Infections and Mycoses
Comparison of species distribution and antimicrobial susceptibility of aerobic actinomycetes from clinical specimens. To compare the species distribution and antimicrobial susceptibility of aerobic actinomycetes, we evaluated 366 isolates referred to the Centers for Disease Control from October 1985 through February 1...
0Bacterial Infections and Mycoses
Enterobacter bacteremia in pediatric patients. Enterobacter has emerged as an important human pathogen, particularly in sick, hospitalized patients. Previous reports of nonepidemic enterobacter bacteremia have focused on adult patients. In this report, the epidemiologic factors, clinical characteristics, treatment, ...
0Bacterial Infections and Mycoses
Quinolone antibiotics in the treatment of Salmonella infections The 4-fluoroquinolones are a new class of antimicrobial agents that possess broad in vitro antibacterial activity, including efficacy against enteric pathogens such as Salmonella, Shigella, Campylobacter, Yersinia, and Vibrio species. These drugs are cl...
0Bacterial Infections and Mycoses
Infectious diseases as a Canadian subspecialty, with projections to the year 2000. Infectious diseases is a relatively new subspecialty in Canada. During the past decade, however, important advances have been made. These include the formation of the Canadian Infectious Diseases Society and the development of the fir...
0Bacterial Infections and Mycoses
Protection of mice against the Lyme disease agent by immunizing with recombinant OspA. Lyme borreliosis is a tick-borne illness caused by Borrelia burgdorferi. The gene for outer surface protein A (OspA) from B. burgdorferi strain N40 was cloned into an expression vector and expressed in Escherichia coli. C3H/HeJ m...
0Bacterial Infections and Mycoses
Giant basilar aneurysm in the course of subacute bacterial endocarditis. We describe a man aged 42 years with mitral valve regurgitation who suffered from subacute bacterial endocarditis caused by Streptococcus morbillorum. The clinical picture began with a toxic syndrome. Five months later, the patient had an embol...
0Bacterial Infections and Mycoses
Percutaneous central venous catheterization. Three years' experience in a neonatal intensive care unit. Prolonged venous access is desirable in very-low-birth-weight infants and infants for whom feedings are contraindicated. We prospectively evaluated 481 small-diameter venous catheters placed percutaneously in 317 p...
0Bacterial Infections and Mycoses
Epidemiology of Lyme disease in Virginia. Prior to January 1986, only one case of Lyme disease was reported from Virginia. In 1986-87, however, the Virginia Department of Health observed an increase in reports of suspected Lyme disease by physicians, despite the fact that Ixodes dammini is not highly prevalent in the...
0Bacterial Infections and Mycoses
Epidemiologic differences between chlamydia and gonorrhea. To assess the prevalence, demographics, and transmission patterns of genital chlamydia infection, we screened 3,078 patients, and compared identified cases (N = 511) to gonorrhea cases (N = 291) diagnosed in the same setting. Chlamydia cases were younger and ...
0Bacterial Infections and Mycoses
Day care characteristics associated with Haemophilus influenzae disease. Haemophilus influenzae Study Group. To identify characteristics of day care facilities associated with H. influenzae disease, we compared 92 licensed facilities in which a case of H. influenzae disease had occurred with randomly selected facili...
0Bacterial Infections and Mycoses
Evidence for gonococcal transmission within a correctional system. In a study to examine sexually transmissible disease occurring within a large correctional system where sexual activity is prohibited, 27 male inmates acquired culture-proven gonorrhea from in-jail sexual activity during a three-month period. These re...
0Bacterial Infections and Mycoses
Recombinant capsular antigen (fraction 1) from Yersinia pestis induces a protective antibody response in BALB/c mice. Yersinia pestis produces a glycoprotein capsule, the biosynthesis of which appears to be temperature dependent. The fraction I (F1) component of this capsule is specific to Y. pestis and the detectio...
0Bacterial Infections and Mycoses
Tetanus immunization status and immunologic response to a booster in an emergency department geriatric population. STUDY OBJECTIVES: Although effective procedures for the prevention of tetanus have long been available, serosurveys done since 1977 demonstrate that 49% to 66% of the elderly population lacks a protective...
0Bacterial Infections and Mycoses
The inactivation of antithrombin III by serum elastase in patients with surgical infections. The relationship between serum elastase and antithrombin III was determined in septic surgical patients as a possible mechanism for intravascular thrombosis and hypercoagulability during sepsis. Eighteen patients with surgica...
0Bacterial Infections and Mycoses
Air contamination in open heart surgery with disposable coveralls, gowns, and drapes. The effect of a polypropylene coverall, replacing shirt and trousers, combined with sterile laminated gowns and drapes compared with an all-cotton system was studied in regard to the dispersion of bacteria and particles in a conventi...
0Bacterial Infections and Mycoses
Antimicrobial prophylaxis for open heart operations. Between 1986 and 1988, 450 adults undergoing coronary artery bypass, cardiac valve replacement, or both were enrolled into a prospective, randomized, comparative trial of cephalothin versus cefamandole as perioperative prophylaxis. They were assessed during their h...
0Bacterial Infections and Mycoses
Seroprevalence of Helicobacter pylori in Seventh-Day Adventists and other groups in Maryland. Lack of association with diet. To evaluate the possible role of diet in the transmission of Helicobacter pylori, we compared H pylori seroprevalence among Seventh-Day Adventists (who are vegetarian and abstain from alcohol, c...
0Bacterial Infections and Mycoses
Does survival depend on the amount of autotransplanted splenic tissue? Susceptibility to Streptococcus pneumoniae infection was studied in 11 groups of rats allocated to sham operation, splenectomy, or splenic autotransplantation of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, or 90% of the removed spleen. Three months la...
0Bacterial Infections and Mycoses
Immunogenicity in animals of a polysaccharide-protein conjugate vaccine against type III group B Streptococcus. The native capsular polysaccharide of type III group B Streptococcus elicits a specific antibody response in only 60% of nonimmune human subjects. To enhance the immunogenicity of this polysaccharide, we co...
0Bacterial Infections and Mycoses
The national immunization program of The Netherlands. After a brief explanation of the immunization policy in the Netherlands, the national immunization program is described, with special attention given to coupling of the municipal population records with a computerized database of individual immunization records at ...
0Bacterial Infections and Mycoses
Postneonatal infectious disease mortality: the French situation. Mortality caused by infectious and parasitic diseases represents a limited part of all postneonatal deaths in France, which have been stable for the past decade. This component is worthy of careful analysis because it is at least partially preventable. ...
0Bacterial Infections and Mycoses
Postneonatal mortality in Norway: a study of recent trends and comparison with other mortality rates in Norwegian children. Postneonatal mortality in Norway decreased rapidly from 1956 to 1980 but subsequently remained stable. In recent years the postneonatal death rate appears to be increasing, primarily due to grea...
0Bacterial Infections and Mycoses
Botulism among Alaska Natives. The role of changing food preparation and consumption practices. Alaska Natives have one of the highest rates of food-borne botulism worldwide. All outbreaks have been associated with the consumption of native foods, but in recent years outbreaks have occurred in previously unaffected a...
0Bacterial Infections and Mycoses
Impetigo. Current etiology and comparison of penicillin, erythromycin, and cephalexin therapies. We attempted to determine the causative bacterial pathogens of impetigo in children in our area, to compare the effectiveness of three frequently used oral antimicrobial treatment regimens, and to correlate the antimicrobi...
0Bacterial Infections and Mycoses
Lung function in children following empyema. Spirometry was performed and response to exercise was measured in 15 children following recovery from empyema to evaluate the impact of pleural infection on subsequent lung function. Seven children underwent chest tube drainage; eight did not. The two groups were similar ...
0Bacterial Infections and Mycoses
Group B streptococcus endocarditis following second-trimester abortion. An 18-year-old woman who underwent an elective second-trimester abortion developed Streptococcus agalactiae (group B streptococcus) endocarditis characterized by a large, pedunculated vegetation involving a previously normal tricuspid valve. Poly...
0Bacterial Infections and Mycoses
Initial evaluation of human monoclonal anti-lipid A antibody (HA-1A) in patients with sepsis syndrome. HA-1A, a human monoclonal immunoglobulin M antibody that binds specifically to the lipid A domain of endotoxin, was administered to septic patients to evaluate the safety, pharmacokinetics, and immunogenicity of the ...
0Bacterial Infections and Mycoses
Dependence of oxygen consumption on oxygen delivery in children with hyperdynamic septic shock and low oxygen extraction. We studied the effect of increasing systemic oxygen delivery (DO2) by packed RBC (PRBC) transfusion on oxygen consumption (VO2) in children with hyperdynamic septic shock. After routine resuscitat...
0Bacterial Infections and Mycoses
Accuracy in early prediction of prognosis of patients with septic shock by analysis of simple indices: prospective study. In 26 consecutive septic shock patients, we analyzed the clinical, hemodynamic, and metabolic data before and during volume infusion to test their circulatory reserve in response to fluid repletion...
0Bacterial Infections and Mycoses
Pseudomonas aeruginosa compared with Escherichia coli produces less endotoxemia but more cardiovascular dysfunction and mortality in a canine model of septic shock. We investigated the effects of two different Gram-negative bacteria and radiation-induced leukopenia on endotoxemia, cardiovascular abnormalities, and mor...
0Bacterial Infections and Mycoses
Reduction of contamination at total hip replacement by special working clothes. We assessed wound, air and operative field contamination at 50 total hip operations, performed in a zonal ventilation system. Theatre staff wore either a specially designed polypropylene non-woven coverall or conventional cotton shirt and...
0Bacterial Infections and Mycoses
Lack of association between medication use and the presence or absence of bacteriuria in elderly women. This study was undertaken to determine if there is an association between medication use and the presence or absence of bacteriuria in elderly ambulatory women. Of 198 women who participated in three urine culture ...
0Bacterial Infections and Mycoses
Absence of significant bacteremia during urinary catheter manipulation in patients with chronic indwelling catheters. The objective of this study was to quantify the microorganisms present in blood at urinary catheter removal and at reinsertion in patients with chronic indwelling urinary catheters. This was a prospec...
0Bacterial Infections and Mycoses
Mycobacterium leprae-specific T cells from a tuberculoid leprosy patient suppress HLA-DR3-restricted T cell responses to an immunodominant epitope on 65-kDa hsp of mycobacteria. The polar tuberculoid type (TT) of leprosy, characterized by high T cell reactivity to Mycobacterium leprae, is associated with HLA-DR3. Sur...
0Bacterial Infections and Mycoses
A general model of sexually transmitted disease epidemiology and its implications for control. Achieving control of STDs may be possible by integrating the activities discussed previously with further research to provide additional empiric data on sex behavior, to develop innovative strategies to access and communicat...
0Bacterial Infections and Mycoses
Syphilis in adults. This article reviews the clinical manifestations of syphilis, diagnostic tests that might help to diagnose accurately the disease, and current recommendations for therapy. The association of syphilis and human immunodeficiency virus infection raises additional questions related to transmission, di...
0Bacterial Infections and Mycoses
Amoxycillin plus probenecid versus doxycycline for treatment of erythema migrans borreliosis. 72 adults with erythema migrans (early Lyme borreliosis) were enrolled in a randomised prospective trial comparing amoxycillin 500 mg plus probenecid 500 mg three times a day with doxycycline 100 mg twice a day for 21 days. ...
0Bacterial Infections and Mycoses
Bird attack on milk bottles: possible mode of transmission of Campylobacter jejuni to man A case-control study was carried out to test the hypothesis that the rise in the rate of Campylobacter jejuni infection in the Brigend area of South Wales during May was due to the consumption or handling of milk from bottles th...
0Bacterial Infections and Mycoses
Interleukin-1 receptor antagonist reduces mortality from endotoxin shock. About five out of 1,000 patients admitted to hospital develop bacterial sepsis leading to shock, the mortality rate for which is high despite antibiotic therapy. The infection results in hypotension and poor tissue perfusion, and eventually lea...
0Bacterial Infections and Mycoses
End of preview. Expand in Data Studio

This dataset is an adaptation of the Ohsumed dataset made available in https://github.com/yao8839836/text_gcn, wich removes records from the original Ohsumed corpus belonging to more than one desease category. The dataset is divided into the same train and test splits defined in the original repository.

Numerical labels were converted to ClassLabels using string descriptors as names, based on the following relation (adapted from this repo):

Label Original Category Name
0 C01 Bacterial Infections and Mycoses
1 C02 Virus Diseases
2 C03 Parasitic Diseases
3 C04 Neoplasms
4 C05 Musculoskeletal Diseases
5 C06 Digestive System Diseases
6 C07 Stomatognathic Diseases
7 C08 Respiratory Tract Diseases
8 C09 Otorhinolaryngologic Diseases
9 C10 Nervous System Diseases
10 C11 Eye Diseases
11 C12 Urologic and Male Genital Diseases
12 C13 Female Genital Diseases and Pregnancy Complications
13 C14 Cardiovascular Diseases
14 C15 Hemic and Lymphatic Diseases
15 C16 Neonatal Diseases and Abnormalities
16 C17 Skin and Connective Tissue Diseases
17 C18 Nutritional and Metabolic Diseases
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To cite the original work:

@InProceedings{10.1007/BFb0026683,
  author="Joachims, Thorsten",
  editor="N{\'e}dellec, Claire
  and Rouveirol, C{\'e}line",
  title="Text categorization with Support Vector Machines: Learning with many relevant features",
  booktitle="Machine Learning: ECML-98",
  year="1998",
  publisher="Springer Berlin Heidelberg",
  address="Berlin, Heidelberg",
  pages="137--142",
  abstract="This paper explores the use of Support Vector Machines (SVMs) for learning text classifiers from examples. It analyzes the particular properties of learning with text data and identifies why SVMs are appropriate for this task. Empirical results support the theoretical findings. SVMs achieve substantial improvements over the currently best performing methods and behave robustly over a variety of different learning tasks. Furthermore they are fully automatic, eliminating the need for manual parameter tuning.",
  isbn="978-3-540-69781-7"
}
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