entry stringlengths 6 10 | entry_name stringlengths 5 11 | protein_name stringlengths 3 2.44k | sequence stringlengths 2 35.2k | function stringlengths 7 11k |
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A0A1S4AUX8 | ODC1A_TOBAC | Ornithine decarboxylase 1A, chloroplastic (EC 4.1.1.17) | MAGQTIIVSGLNPAAILQSTIGGGASPTAAAAENGTRKVIPLSRDALQDFMLSIITQKLQDEKQPFYVLDLGEVVSLIDQWKSALPNIRPFYAVKCNPEPSFLSILSAMGSNFDCASRAEIEYVLSLGISPDRIVFANPCKPESDIIFAAKVGVNLTTYDSEDEVYKIRKHHPKSELLLRIKPMFDGNARCPMGPKYGALPEEVEPLLRAAQAARLTVSGVSFHIGSGDADSNAYLGAIAAAKEVFETAAKLGMSKMTVLDVGGGFTSGHQFTTAAVAVRSALKQHFDDQPELTIIAEPGRFFAETAFTLATTIIGKRVR... | Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins) nornicotine serves as the precursor in the synthesis of the carcinogen... |
A0A1S4BDC4 | MPO1_TOBAC | N-methylputrescine oxidase 1, peroxisomal (NtMPO1) (EC 1.4.3.-) (Copper methylamine oxidase) (EC 1.4.3.21) | MATTKQKVTAPSPSPSSSTASCCPSTSILRREATAAIAVVGDGLQNWTNIPSVDEKQKKTASSALASLPTTEPLSTNTSTKGIQIMTRAQTCHPLDPLSAAEISVAVATVRAAGETPEVRDGMRFIEVVLVEPDKSVVALADAYFFPPFQSSLMPRTKGGSQIPTKLPPRRARLIVYNKKTNETSIWIVELNEVHAAARGGHHRGKVIASNVVPDVQPPIDAQEYAECEAVVKSYPPFRDAMRRRGIDDLDLVMVDPWCVGYHSEADAPSRRLAKPLVFCRTESDCPMENGYARPVEGIYVLVDVQNMQIIEFEDRKLVP... | Involved in the biosynthesis of pyridine alkaloid natural products, leading mainly to the production of anabasine, anatabine, nicotine and nornicotine, effective deterrents against herbivores with antiparasitic and pesticide properties (neurotoxins) nornicotine serves as the precursor in the synthesis of the carcinogen... |
A0A1S4F020 | CBPB1_AEDAE | Carboxypeptidase B1 (AaCPB-I) (CPBAe1) (EC 3.4.17.2) | MIPRIVVVLLSVLAVVTARRSYEGYKVYGIVPESPDEAEILYQIRQSNPDLDFWHLTKQPGDEARVLVAPKDQRSFLIKLIRHGLHYQEVISDVEGTLAPYNEPRTRGMSLDRDVSTSYLRHNEINEYLQTLSQKYPSLVSVEEAGTSYEGRSIKTITINKKPGNAVVFLDAGIHAREWIAPATALYAIEQLVEHSSENQEVLSNLTWVIMPVVNPDGYEFSHETDRFWRKTRKPTGKTCKGTDGNRNFDYHWGEVGASTQACADTFRGETAFSEPETRAVRDAVMKLKGSCKFYLSLHSYGNYILYPWGWTSKLPETWE... | Carboxypeptidase that preferentially hydrolyzes arginine and lysine residues at the C-terminus. During infection by dengue virus, may play a role in preventing viral packaging, maturation, and release from the midgut. |
A0A1S4GMJ4 | CLC9_ANOGA | CLIP domain-containing serine protease C9 (EC 3.4.21.-) [Cleaved into: CLIP domain-containing serine protease C9 subunit p12; CLIP domain-containing serine protease C9 subunit p30] | MCILTLVERKHLKNMVHVRLLVMMHILIIYSTFGAVRRPINIRVLEGNSCDTPQVIGGKCMNISLCDPAFVHSIAYQEHTPVCQQNAFYRVICCQPFLDFCENSKQFQIMHGIEAEPGMFPHLARLGLKSEEDGIAWTCSANIISERFLLTAAHCNPVNIAGLGCAESMQCDQQNTVKSFISNPKYKTSFKYHDIALVELEQNIRFNKRVLPICPYISKTDLHESEDLVIAGWGATESHFQSPRLMFATVRTVLQNDCKDHYASLLKASPNKKLHQGITDEMYCAQGALVDNVTEYIDACSGDSGGPLQTKQNNNLYLIG... | Probable serine protease which plays an essential role in the innate immune response against bacteria and protozoa infection by activating the melanization cascade. In the susceptible strain G3, appears to be dispensable for ookinete elimination which occurs by lysis. |
A0A1S4H5M5 | CLA28_ANOGA | Inactive CLIP domain-containing serine protease A28 [Cleaved into: Inactive CLIP domain-containing serine protease A28 light chain; Inactive CLIP domain-containing serine protease A28 heavy chain] | MKVLLFCIVISLTTLIASGQDIEEELRCPGGYCVSKYLCPNGTFIDDIKHAQTTQLIGLRAGLDIDDFDDCNDYLLVCCQSAPAPTATSTEKPATSDELIEPPPSTNLACGQANEGGLIYDLRNNETLSQYAEYPWVVYILALKKQEANSGDFVCGGTLIHSRLVVTTAHNTDGKTDLVARFGEWDISTTKEPFPQQDIDVAEVIKHPQYVFNPIQNDIALLVLAENVQYAAHIRPICLPQPTDEFVGQRCVSNGWGKERGVYANVMKKLTLPVIGRANCTRMLRYAGLGPFYTLREGFLCAGGEVAVDMCKGDGGSPLA... | Inactive serine protease which plays an essential role in the innate immune response against bacteria, fungi and protozoa infection by activating the melanization cascade. In the melanization cascade, acts downstream of TEP1, SPCLIP1 and CLIPA8 to promote CLIPC9 proteolytic cleavage. In the susceptible strain G3, appea... |
A0A1S4H5S2 | CLA8_ANOGA | Inactive CLIP domain-containing serine protease A8 [Cleaved into: Inactive CLIP domain-containing serine protease A8 light chain; Inactive CLIP domain-containing serine protease A8 heavy chain] | MPSWWCCCCLVVLLYAQRMIVPSSAQNDGSDELQECPGGFCSPKYLCPNGTYNEANAQNQEIIMLRFGEEDVCQDYMQVCCSNATSMRYELVTNNEPVEYGCGISNPGGLIYQVEGNRTYAQYGEFPWVVAILEAFYSSNEQQFTYVGGGTLIHPRFVVTAAHIFNKTENLVASFGEWDMNRDENVYPKQNIDIDRTIIVHPEYNSVGLLNDIALAQLKQNVVYDKHIRPICLPNPTDRFDDQLCISTGWGIEALTSAYANVLKRVDLPVIARASCKKLFAETRLGPFFRLHKSVLCAGGEEGADMCDGDGGSGLACPNE... | Inactive serine protease which plays an essential role in the innate immune response against bacteria, fungi and protozoa infection by activating the melanization cascade. In the melanization cascade, acts downstream of TEP1 and SPCLIP1 to promote CLIPA28 and CLIPC9 proteolytic cleavage and CLIPC9 recruitment to microb... |
A0A1S4HE51 | CLA30_ANOGA | Inactive CLIP domain-containing serine protease A30 (Inactive CLIP domain-containing serine protease SPCLIP1) | MAFSLRIGIRTTDSKRCLVLLVLVVLLTVLACLPPSVEGNFPVGKFRRCNNNKGICVSREQCLNGQINTVGHTQIEPRLLNDDDIDECDVYGMQCCNLPSTNVPADSDEEEQEEEEKEKKGGTVTTTTTEEPDDPDWSRQCGQRTDVTERADQDGETNRFEFPWSVALFSKAQFFGKVRKEFLCGGTLIDDYLVLTAARCVNQKDRNTLVVQLGRWNLDAGKESRMQEIAVEELIIHRGYVLSSHLHNVALLVLANGAQLGRAANRVCLPDHSVQFGPDTLCYVVGWSNSPSPNTSNRQLKLRSMVAPVQECTATIRRST... | Probable inactive serine protease which plays an essential role in the innate immune response against bacteria and protozoa infection by activating the melanization cascade. Binds to the surface of parasite P.berghei ookinetes and bacterium E.coli where it promotes the accumulation of mature TEP1 which leads to the mel... |
A0A1S4NYE3 | CDIA_ECOST | tRNA nuclease CdiA (tRNase CdiA) (EC 3.1.-.-) (Contact-dependent inhibitor A) (CdiA-STECO31) (Toxin CdiA) | MHQPPVRFPYRLLSYLISTIIAGQPLLPAVGAVITPQNGAGMDKAANGVPVVNIATPNGAGISHNRFTDYNVGKEGLILNNATGKLNPTQLGGLIQNNPNLKAGGEAKGIINEVTGGNRSLLQGYTEVAGKAANVMVANPYGITCDGCGFINTPRATLTTGRPVMNADGSLQALEVTEGSITINGAGLDGTRSDAVSIIARATEVNAALHAKDLTVTAGANRVTADGRVSALKGEGDVPKVAVDTGALGGMYARRIHLTSTESGVGVNLGNLYAREGDIILSSSGKLVLKNSLAGGNTTVTGTDVSLSGDNKAGGNLSVT... | Toxic component of a toxin-immunity protein module, which functions as a cellular contact-dependent growth inhibition (CDI) system. CDI modules allow bacteria to communicate with and inhibit the growth of closely related neighboring target bacteria in a contact-dependent fashion (target cell counts decrease 1000- to 10... |
A0A1S5RW73 | KPS_SALDI | (-)-kolavenyl diphosphate synthase, chloroplastic (SdKPS) (EC 5.5.1.28) (Clerodienyl diphosphate synthase) (Kolavenyl diphosphate synthase CPS2) (SdCPS2) | MSFATSLPRPTTTGAAGFGLPLATCISLSVSHSFSPKFGICNNTSLRLKSKAGSGCYEGIHRSQLAASTILEGHTPINPEVESEKIRLIERIRLMFRSMDDGEISVSPYDTAWVALVEDIGGSGGPQFPTSLEWISNNQLDDGSWGDRKFVLYDRILNTLACVVALTTWKMHPNKCEKGLRFISDNIEKLADEDEELMPVGFEIALPSLIDLAKRLCIEIPDNSASIKNIYAKRDSKLKRIPMDLMHKKPTSLLFSLEGMEGLNWDKLLDFQSEGSFLSSPSSTAYALHHTKDELCLEYLLKAVKKFNGGVPNAYPVDMF... | Involved in the biosynthesis of clerodane diterpenoids natural products, including salvinorin A with potent agonistic activity on brain kappa-opioid receptors, thus confering hallucinogenic properties. Diterpene synthase that catalyzes the formation of (-)-kolavenyl diphosphate from geranylgeranyl diphosphate (GGPP) as... |
A0A1S6M251 | B4GT5_PIG | Beta-1,4-galactosyltransferase 5 (Beta-1,4-GalTase 5) (Beta4Gal-T5) (b4Gal-T5) (EC 2.4.1.-) (Beta-1,4-GalT II) (Glucosylceramide beta-1,4-galactosyltransferase) (EC 2.4.1.274) (Lactosylceramide synthase) (LacCer synthase) (UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 5) (UDP-galactose:beta-N-acetylglucosamine bet... | MRVRRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLFMMQAQGILIRDNMRTIGAQVYEQVVRSAYAKRNSSVNDSDYPLDLNHSETFLQTTTFLPEDFTYFANHTCPERLPSMKGPIDINMSEIGMDTIHELFSKDPAIKLGGHWKPSDCVPRWKVAILIPFRNRHEHLPVLLRHLIPMLQRQRLQFAFYVVEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLVFHDVDHIPENDRNYYGCGQMPRHFATKLDKYMYLLPYNEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGD... | Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (By similarity). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation a... |
A0A1S7LCW6 | MAMP_MAGMO | Multi-heme protein MamP (EC 1.-.-.-) (Magnetochrome MamP) (Magnetosome-associated protein MamP) | MKLKGTTIVALGMLVVAIMVLASMIDLPGSDMSATPAPPDTPRGAPIVGGQGQAMGLPVAMQRRRGEQRAPVPALSDANGGFVAPNVQFSEAHWQGMEALPLSIELKRKLKLPLDLEGLLIDETSLNAAVSGLLAGDVLVAINGRKVKTLKKMQKETRRVQMDRRASLTVYRKGRLLTLTLSEEKNLGLAQVETAPMILPGDIMPHPYRGPCTQCHAIGTTGHITPDPDGIVLPPGPIRAGAKMPHRDRGPCAACHAIIQ | Oxidizes Fe(2+) at alkaline pH successively forms ferrihydrite (Fe(3+)(2)O(3) 0.5 H(2)O) then magnetite (Fe(3)O(4)) from an Fe(2+) solution. |
A0A1U8F5V2 | IFI4E_CAPAN | Eukaryotic translation initiation factor isoform 4E (eIF(iso)-4E) (eIF(iso)4E) (eIF-(iso)4F 25 kDa subunit) (eIF-(iso)4F p28 subunit) (mRNA cap-binding protein) | MATEAPPPVDTTEVPPFTAAETAVKQPHKLERKWTFWFDNQSKPKQGAAWGSSLKKAYTFDTVEEFWSLYDQIFKPSKLTVNADFHLFKAGIEPKWEDPECANGGKWTVTSSRKANLETMWLETLMALVGEQFDDSEDICGVVASVRRSQDKLSLWTKTATNEAAQMGIGRKWKEIIDTEKISYSFHDDSKRERSAKSRYTV | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of prote... |
A0A1U8GR65 | IF4E1_CAPAN | Eukaryotic translation initiation factor 4E-1 (eIF4E-1) (eIF-4F 25 kDa subunit) (eIF-4F p26 subunit) (mRNA cap-binding protein) | MATAEMEKTTTFDEAEKVKLNANEADDEVEEGEIVEETDDTTSYLSKEIATKHPLEHSWTFWFDNPVAKSKQAAWGSSLRNVYTFSTVEDFWGAYNNIHHPSKLVVGADLHCFKHKIEPKWEDPVCANGGTWKMSFSKGKSDTSWLYTLLAMIGHQFDHEDEICGAVVSVRGKGEKISLWTKNAANETAQVSIGKQWKQFLDYSDSVGFIFHDDAKRLDRNAKNRYTV | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and... |
A0A1U8QK63 | PKIC_EMENI | Fatty acid synthase beta subunit pkiC (EC 2.3.1.86) [Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase [NADH] (EC 1.3.1.9); [Acyl-carrier-protein] acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] malonyltransferase (EC 2.3.1.39); S-acyl fatty acid sy... | MALEEVPSVSRDLDHSALRALSSASPSSLPSSCSRSTTSLLFQSKGIEFRLSIPDTFLSLVEPHRNAFLASYSTQGNTQSPLELALSFLYFLLDQKVSPLVLSSVLRAFNLEFLGNRSEIHSLIADLTPIPKQRQRWLGIYYRFLEASDDKRAEIPLSSIFQHARTNEFQLMAVFGGQGECSRTCLNEFAELYSSYEPMLRRLVGVIGPCLYNLSTSDEYSSYYRNQPLDLKAWITDENHVPDLGFVASAPVSVPVIGALSLARYCVTCHITGCNPGLMRSMLRTATGHSQGLLAAIVVAVSHSWDSFYQATEEVIELLF... | Fatty acid synthase beta subunit part of the pki gene cluster that mediates the biosynthesis of 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde. The first step in the pathway is the generation of the decanoyl starter unit by the FAS composed of subunits pkiB and pkiC, which is then transferred directly from the FAS... |
A0A1U8QLG8 | PBCB_EMENI | Geranylgeranyl pyrophosphate synthase AN1592 (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)... | MSPPLDSALEPLSEYKETAFPRTEKDPSQYKEHDLVTPEKEIQTGYFSPRGSHSSHGSHDSSASSNISLDDARMSDVNNSPNVFHDDPDTIDEKLSMYWKAANETVIREPYDYIAGIPGKEIRRKLLEAFNHWYKVDEQSCQAIATTVGMAHNASLLIDDIQDSSKLRRGVPCAHEVFGIAQTINSANYVYFLAQNQLFRLRSWPQAISVFNEEMVNLHRGQGMELFWRDNLLPPSMDDYLQMIANKTGGLFRMIVRLLQTSSRQVIDVEQLVDVLGLYFQILDDYKNIREEKMAAQKGFFEDLTEGKFSFPICHAIGEG... | Geranylgeranyl pyrophosphate synthase part of the gene cluster that mediates the biosynthesis of the diterpene ent-pimara-8(14),15-diene (PD). Within the cluster, the HMG-CoA reductase AN1593 functions in the mevalonate pathway, which produces isoprenoid precursors. The geranylgeranyl pyrophosphate (GGPP) synthase AN15... |
A0A1U8QNG8 | HXNS_EMENI | Nicotinate hydroxylase hnxS (EC 1.-.-.-) (Nicotinate catabolism cluster protein hxnS) (Purine hydroxylase II) (PHII) (Xanthine dehydrogenase II) | MDALLPRSSPQLKFYLNGTPISLTSPHPRWTLLDFIRSQDGLKGTKLGCGEGGCGALSGKHVITIEGLGTVDHPHPLQERIAQLHGSQCGFCTPGIVMSLYAMIRNAYDPVTGKFQLSADDIESKGHLDGNLCRCTGYKPILNAARTFIEDDLGSVPSIVESELVGTEEETESDMGAHSGSGDTGSRSSGSCGRPGGCCKDSPGISSCSSRETDMTTPSLPDSPVLKQYDFIPYTPTTELIYPPGLAKFVPELLCYGDAEQAWVKPRSVQEALEILSQCPSATLVTGASEVQVDVRFKDFRPSVSVFVGDITEMTGISWS... | Nicotinate hydroxylase, part of the hnx cluster involved in the purine degradation. The nicotinate hydroxylase hnxS accepts nicotinate as a substrate and catalyzes the first step of nicotinate catabolism. HnxS accepts also hypoxanthine, but not xanthine, as a substrate. The major facilitator-type transporters hxnP and ... |
A0A1U8QWA2 | ATR12_EMENI | Glycine betaine reductase ATRR (Nonribosomal peptide synthetase-like protein ATRR) [Includes: Carboxylic acid reductase (EC 1.2.1.-); Aldehyde reductase (EC 1.1.1.-)] | MAIIDTTKDLSALFTQQVRASPNALALEDDKTSYTYAELDKEVEELSRRLRSYGVSRDSLVGVLLPRSAHFVIACLAALRAGGAFLVLELAYPPDLLADVLEDATPAVVVTHRSETGKIKGSVPVISLDEPPVDANGHTVEPGPLPVDDDLDRLAFVSYSSGTTGKPKGIANPHRAPVLSYNLRFGVQDLQPGDRVACNVFFIWEILRPLIRGATVVAVPDDHSYDPAALVDLLASRHITETLMTPTLLATILSRHSDIGARLPELRTLWLNGEVVTTDLARRAIRALPNTRLLNCYSACETHEIACGDIKEIVSDESQY... | NRPS-like enzyme with an unusual domain architecture that converts back glycine betaine to choline via a 2-step reduction mechanism, and thereby can be an alternative source of choline. Permits direct reutilization of endogenously stored glycine betaine for on-demand biosynthesis of choline and choline derivatives, inc... |
A0A1V0E492 | TPS1_PIPNI | Terpene synthase 1 (PnTPS1) (Alpha-humulene synthase) (EC 4.2.3.104) (Beta-caryophyllene synthase) (PnCPS) (EC 4.2.3.57) | MACVSDLVAFTQPLIIGAKPLEIVRRSAAFHPNVWGDYFLKLSQDEKKLESMRERAKVLKEKVLKKLSTIEGGERLELIDTLYHLGVAYNFEKEIEEALEKIYKAYDEDATQDNLCTLALRFRLLRQHGWNASSDVFNKFKETKNGNFKESVASDVLGMLSLYEASYVGTKEDKILEEAISFTTRNLSAALPNMEPLLAERVAHSLELPLHKRLQRLEARYFITMYEKNNAHDEMLLEYAKLDYNLLQALHQNEMKELTKWWTKIDLVGKMKFPRDRVTECYFWPLGAFFEPQHSRGRIFATKITQLTSIIDDLYDVYGT... | Sesquiterpene synthase involved in the biosynthesis of volatile compounds that contribute to the characteristic flavors of black pepper. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into beta-caryophyllene and, as a minor compound, into alpha-humulene. |
A0A1V0E4A6 | TPS2_PIPNI | Terpene synthase 2 (PnTPS2) (Cadinene synthase) (PnCDS) (EC 4.2.3.-) (Cadinol synthase) (PnCO) (EC 4.2.3.-) | MDAVSCAINALSAQAPPKHLGGNNVGRKSVTFPKDIWGDYFLKISPNEEKLDSWRVRAKELKEKVFDILSCAKGAEQVHIIDALYHLGVSYQFEKEIEEALKNMLTTYNDDTSTEDDLYTLALRFRLLRQNGFHASTKALNKFKDAHGSFREDLASDVMGLLSLYEASYAGTVDDLILDEALAFTKIHLKAALPHLDSHLAQRVSHSLELPLHKRIQRLEAREFISLCEKDDSIVIKELLEFAKLDYNILQALHQWELKELTKWWKKLNLVGKMTFARDRMTEIYFYVSGFFFEPQYSRGRIISSKILAICSVVDDEYDV... | Sesquiterpene synthase involved in the biosynthesis of volatile compounds that contribute to the characteristic flavors of black pepper. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into alpha-cadinene, delta-cadinene and delta-cadinol. |
A0A1W2P872 | NOVA2_MOUSE | RNA-binding protein Nova-2 | MEPEAPDSRKRPLETPPEVVCTKRSNTGEEGEYFLKVLIPSYAAGSIIGKGGQTIVQLQKETGATIKLSKSKDFYPGTTERVCLVQGTAEALNAVHSFIAEKVREIPQAMTKPEVVNILQPQTTMNPDRAKQAKLIVPNSTAGLIIGKGGATVKAVMEQSGAWVQLSQKPEGINLQERVVTVSGEPEQVHKAVSAIVQKVQEDPQSSSCLNISYANVAGPVANSNPTGSPYASPADVLPAAAAASAAAASGLLGPAGLAGVGAFPAALPAFSGTDLLAISTALNTLASYGYNTNSLSLGLNSAAASGVLAAVAAGANPAA... | Functions to regulate alternative splicing in neurons by binding pre-mRNA in a sequence-specific manner to activate exon inclusion or exclusion. It binds specifically to the sequences 5'-YCAY-3' and regulates splicing in only a subset of regulated exons. Binding to an exonic 5'-YCAY-3' cluster changes the protein compl... |
A0A1W5T1U1 | POXE_PENOX | Hybrid PKS-NRPS synthetase poxE (PKS-NRPS) (EC 2.3.1.-) (EC 6.3.2.-) (Oxaleimides biosynthesis cluster protein E) | MAPSQAPREPIAIVGSGCRFPGESSSPSKLWELLQAPRDVQTEIPPTRFNPHGFYHPDNLHHGTSNVRHSYLLTEDHRHFDAQFFGIKPAEAHCIDPQQRLLMETVYESLESAGLRLEDLRGSETAVYVGLMCGDYADIVLRDPESFPMYLSTGTARSIMSNRISYFFDWHGPSMTIDTACSSSLVAVHEAVQTLRLGRSRVAVAAGSNLCLSPEPYIAESKLQMLSPTGRSRMWDIQADGYARGDGVAAVVLKTLSAALADGDHIECLIRETSVNQDGRTRGITMPSSEAQTRLIQDTYARAGLDPLKPQERCQYFEAH... | Hybrid PKS-NRPS synthetase part of the gene cluster that mediates the biosynthesis of oxaleimides, cytotoxic compounds containing an unusual disubstituted succinimide moiety. The first step of the pathway is provided by the HR-PKS poxF that serves in a new mode of collaborative biosynthesis with the PKS-NRPS poxE, by p... |
A0A1Z0YU59 | MAMB1_DENAN | Mambaquaretin-1 (MQ-1) (MQ1) (Upsilon-Da2a) | RPSFCNLPVKPGPCNGFFSAFYYSQKTNKCHSFTYGGCKGNANRFSTIEKCRRTCVG | Selectively interacts with vasopressin V2 receptor (V2R/AVPR2) and fully inhibits three major signaling pathways of this receptor that are GalphaS protein, the interaction with beta-arrestin and activation of MAP kinase. Inhibits vasopressin binding human V2R in the nanomolar range (Ki=5.02 nM), and also potently inhib... |
A0A1Z2R986 | EGLN_DANRE | Endoglin | MKSICCVLVLCLLLCRRSTASESICELKDVSGNSNDWIVLREKPLGCWTDFQTENGTEVHIINLEDNPSVFTVNLLKANKSVVIFTSSSAQSSHAMLFDNPAVSIYVTNKTSLTFIHPTQKPLQILTAPPAGNVSAVLRWAAETFGGVTSVTNARNPKTITFTGVKGSQNSSRCELMPETPTEKPFIHLELNEPIEALKSCYMKHEGEKLHIINIPDGVTIRHVSVHLLSDCNVVLRGPAGTHWIIKNSLRIGILSNNQIHLQSFPLRPRMAISDNPTDIRQKALSYFSSGFISSYSEIRLNVTNVELWITDYSISSAPT... | Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Important for endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology duri... |
A0A218N034 | WTF4_SCHKA | Meiotic driver wtf4 | MKNKDYPLRSSMDELSTKNDNEIDLEKGPLPEYNSEDESTLPPYSEIWKYIKTVSEDSSTGPTETTNPNVERRQEFKDSHPNIYSLLRLLISVLAVIVVFFTAWVCVNPLEKSIFGKVAFFVTIGITCPILLITIFCFFETWTQAVAQCIKVTVIFLAQCVKVTAVGLYNSREKWVVIIWLLWVVICYTLFLRSKFGNLNLNKALICSTCSISAALLLFLLYVRLPFWTLKHMFSGLFQVLGVQSCVVIVTKGLTYLFDKHIDATGYEIEASSLFVIGNFLFFYEMECPGALKRMPKFIRNGIASFLEGIGNIGRAFRGA... | Promotes unequal transmission of alleles from the parental zygote to progeny spores by acting as poison/antidote system where the poison and antidote proteins are produced from the same locus the poison component is trans-acting and targets all spores within an ascus whereas the antidote component is spore-specific, le... |
A0A219CMY0 | BMNL5_BOMOR | Bombinin-like peptides [Cleaved into: Bombinin-BO1; Bombinin H-BO1] | MNFKYIIAVSFLIASAYARSEEYDIQSLSQRDVLEEESLRKIRGIGSAILSAGKSIIKGLAKGLAEHFGKRTAEDHEVMKRLEAAMRDLDSLDYPEEASERETRGFNQEEKEKRIIGPVLGLVGKALGGLLG | [Bombinin-BO1]: Has antimicrobial activity against Gram-negative bacterium E.coli (MIC=26.3 uM), Gram-positive bacterium S.aureus (MIC=26.3 uM) and yeast C.albicans (MIC=52.5 uM). Has moderate hemolytic activity towards human erythrocytes at a concentration of 52.2 uM. |
A0A250YGJ5 | SIR6_CASCN | NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVRQSSNVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFENARPTQTHMALVQLERVGLLHFVVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKTTGRLCTVAKARGLRACRGELRDTILDWEDALPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGKLVIVNLQPTKHDRHADLRIHGYVDDVMTQLMKHLGLEIPAWDGPRVLEKALPPLPRPPTPKLEPTDKSLAQLNGSVPADSKPEPC... | NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging (By similarity). Displays protein-lysine deacetylase or defatty-acylase (demyristoylase and depalmitoylase) a... |
A0A286R227 | NIA_ULVPR | Nitrate reductase [NADH] (NR) (EC 1.7.1.1) | MGVRHSASKDYIAGRPLVPGEAPLDKKNSNFSSWKPVTEIDDRDAKCADNWVPRHPDLIRLTGKHPFNSEPPHADVMKEGWLTPVSMHFVRNHGAVPRLEWGSHRITITGLVERPMEITMDDIAKLPAVTVPCLLTCCGNRRKEVNMVKNSQGFSWGPGAVSVNNWTGARLSDVLKLVGVKSQAQGAKYVHFCGPKGELPKGVDGSYGTALTLGHALDPSMDVLIAYKQNGQFLHPDHGFPCRMLIPGWIGGRSVKWLSHLHVSDKDSQNWYHFHDNKVLPPHVDAESAAKQGWWKDPSFILKELNINSTISSPGHDERI... | Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria. |
A0A286Y9D1 | PHF14_DANRE | PHD finger protein 14 | MDRGSKRRQVKPLADSLLDALDYDSSDDSDFKVGESSGSEGTGNGSDEEGSKESAAGSESDSDAAAASADEEGIDDLETKDLNQEDDEEEKVKESFSEETSSKETGGSSRSRKKGEKSSDMEPNGSATTEENSAEPKKWNLRRNRPMLDFTTMEELNEMDDYDSEDDNDWRPTQGKKKGKASSGKEKEGSGEEDDDDDDGGSDEEDNEDDNDDDDDDDDEGNDDESSSSDSEEEGKKPKKKAGKNTGAFDEEETNDSHSTSHGKGNEDSLLERPQTWSSQRMEHILICCVCLGDNSEDADEIIQCDNCGVTVHEGCYGVD... | Histone-binding protein. Binds preferentially to unmodified histone H3 but can also bind to a lesser extent to histone H3 trimethylated at 'Lys-9' (H3K9me3) as well as to histone H3 monomethylated at 'Lys-27' (H3K27ac) and trimethylated at 'Lys-27' (H3K27me3). Represses PDGFRA expression, thus playing a role in regulat... |
A0A287B8J2 | DCTN1_PIG | Dynactin subunit 1 (150 kDa dynein-associated polypeptide) (p150-glued) | MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLRREGTDSNAKTSKLRGPKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPALTSPGAAPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAES... | Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules provi... |
A0A291NUG3 | STING_PTEPA | Stimulator of interferon genes protein (STING) | MLHSSLHPSIPQPRGRRAKKAAFVLLSVCLVVLWDLGERPEHILQWLMLHLASLQLGLLFKGVCSLVEELRHVHSRYQGSYWKAVRACLGCPIRCGTLLLLSCYFYTPFPNTTHLPFTWTLALLGLSQALSILLDLQDLAPAEVSAVCERRNLNVAQGMAWSFYIGYLRLILPGLPARIHSYNQHHNNLLRGAGSHRLYILFPLDCGVPDDLSMVDPNIRFLHELPLQKADRAGIKSRVYTNSVYELLENGRPVGACVLEYATPLQTLFAMSQDSRAGFSREDRLEQAKLFCKTLEDILADAPECQNNCRLVVYQEPAEG... | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes low production of type I interferon (IFN-alpha and IFN-beta). Compared to other mammals, STING1-dependent type I interferon induction is strongly reduced in bats, suggesting that the cGAS-STING pathway p... |
A0A291NUI4 | STING_RHIFE | Stimulator of interferon genes protein (STING) | MPHSSLHPSIPRPRGHRAKKAAFVLLSTCLAALWELGEPADHILRWLVLHLASEQLGLLFKGLCSLAEEIRHVHSRYQGSYWRAFRACLGCPIRCGVLLLLSCYCYTFLPNTAGLPFAWIVALLGLSQALNILLDLQGLAPAVVSTVCEQGNFNVAHGLAWSYYIGYLRLILPGLQARIHTYNQRHNNTVRGTGVHKLYILLPLDCGVPDDLSVADPNIRFLHELPKQSADRAGIKGRVYTNSIYEILENGKPVGTCVLEYATPLQTLFAMSQDSRAGFSREERLEQAKLFCQTLGDILADVPESQYCRLIVYLDAAEGS... | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes low production of type I interferon (IFN-alpha and IFN-beta). Compared to other mammals, STING1-dependent type I interferon induction is strongly reduced in bats, suggesting that the cGAS-STING pathway p... |
A0A291NUI5 | STING_EIDHE | Stimulator of interferon genes protein (STING) | MSHSSLHPSIPWPRGHKAKVAAFVLLIVCLAALWKLGEPSDHLLQWLVLHLASLHLRLLFKRVCCLAEELCHIHPRYQGNYSRAVRACLGCPIRYGAVLLLSCYFYVSLPNTVDLPLTWMLAHLGLSEALNILLGLQSLTPAEISTICEQRNFNVAHGLAWSYYIGYLQLILPGLRARIHTYNQLHSNTLQGVGSHRLYILFPLDCGVLDDLSAADPNIRFLHELPRQSADRAGIKGRVYTNSVYELLEKGKPVGTCVLEYATPLQTLFAMSQDGRAGFSQEDRLEQAKLFCRTLEDILADAPESQKNCRLIVYQEPTEE... | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes low production of type I interferon (IFN-alpha and IFN-beta). Compared to other mammals, STING1-dependent type I interferon induction is strongly reduced in bats, suggesting that the cGAS-STING pathway p... |
A0A2H4DGV8 | C7BL6_INUHU | Germacrene A acid 8-beta-hydroxylase (Ih8H) (IhG8H) (EC 1.14.14.168) (Cytochrome P450 71BL6) (Germacrene A acid 8-alpha-hydroxylase) (EC 1.14.14.170) | MEPFTTFSLVASSLILLICWALVKANKPAKNLPPGPPKLPIIGNMHQLESQSPHRVLRKLSRKYGPIMHLQLGQVPTVVISTPRLVEEVVKHHDINFADRPTNTTSQIFYYNNQNVAWSSYGNYWRQIKKIVTLELLSVKKVRSFSSIRAEELTRAVKSVEPSVGSTINFRDLTSQTVNNMVSRATLGDVCKERHILLDTMNDILKTFNSFNVVNFFPSLQFLNVITGKKAKWLKIHKQLDHILENILEEHKSKPKGNQDDEDLIDVLLRVKDAGGQELPITNDNVKAITLEMLTAGTSSSSMTIEWAFCELMRHPEVMK... | Involved in the biosynthesis of germacrene-derived sesquiterpene lactones. Hydroxylates germacrene A acid to 8-beta-hydroxy-germacrene A and 8-alpha-hydroxy-germacrene A acids. Unlike 8-alpha-hydroxy-germacrene A acid with is spontaneously converted into inunolide (12, 8-alpha), 8-beta-hydroxy-germacrene A cannot under... |
A0A2I0BVG8 | CDPK1_PLAFO | Calcium-dependent protein kinase 1 (EC 2.7.11.1) (PfCDPK1) | MGCSQSSNVKDFKTRRSKFTNGNNYGKSGNNKNSEDLAINPGMYVRKKEGKIGESYFKVRKLGSGAYGEVLLCREKHGHGEKAIKVIKKSQFDKMKYSITNKIECDDKIHEEIYNEISLLKSLDHPNIIKLFDVFEDKKYFYLVTEFYEGGELFEQIINRHKFDECDAANIMKQILSGICYLHKHNIVHRDIKPENILLENKHSLLNIKIVDFGLSSFFSKDNKLRDRLGTAYYIAPEVLRKKYNEKCDVWSCGVILYILLCGYPPFGGQNDQDIIKKVEKGKYYFDFNDWKNISEEAKELIKLMLTYDYNKRITAKEAL... | Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase. By phosphorylating various proteins, required for microneme secretion and thus merozoite egress from and invasion of host erythrocytes (By similarity). During gam... |
A0A2I0C265 | PLM9_PLAFO | Plasmepsin IX (EC 3.4.23.-) (Plasmepsin 9) | MFFINFKKIKKKQFPIYLTQHRIITVFLIFIYFINLKDCFHINNSRILSDVDKHRGLYYNIPKCNVCHKCSICTHENGEAQNVIPMVAIPSKRKHIQDINKEREENKYPLHIFEEKDIYNNKDNVVKKEDIYKLRKKKKQKKNCLNFLEKDTMFLSPSHDKETFHINHMNKIKDEKYKQEYEEEKEIYDNTNTSQEKNETNNEQNLNINLINNDKVTLPLQQLEDSQYVGYIQIGTPPQTIRPIFDTGSTNIWIVSTKCKDETCLKVHRYNHKLSSSFKYYEPHTNLDIMFGTGIIQGVIGVETFKIGPFEIKNQSFGLV... | During the asexual blood stage, initiates the proteolytic maturation of several rhoptry proteins and thus, is required for merozoite invasion of host erythrocytes and probably the subsequent development of the ring-stage. Cleaves rhoptry associated protein 1 RAP1 and apical sushi protein ASP during schizont maturation.... |
A0A2I4E5L6 | VCL6_JUGRE | Vicilin Jug r 6.0101 (Allergen Jug r 6) (Vicilin Jug r 6) (allergen Jug r 6.0101) | MAFKPKIPIALLLLTSLLAICAGLALAMQDPELKQCKHQCRHQRQFDEQEKEHCQRSCDEYHIEKKARERAERRRSEEGSSREEGYEEEELGGEREEENPYVFEDEDFETRVRTDEGRIQVLEKFTKRSKLLRGIENFRVAILEANPQTFISPAHFDAELVVFVAKGRATITTVREEKRENFNVEQGDIMRIPAGTPVYLINRDENEKLYIVKILRPVSVPGHFEAFHGSGGEDPESFYRAFSWEVLEAALKTRRDQLEKLFGKQTQGVIIKASKEQIRSMSKHEETTPRIWPFGGDSTHPFNLFHKRPSQSNQFGRLFE... | Seed storage protein. |
A0A2I7G3B0 | ALDH1_TANCI | Aldehyde dehydrogenase 1 (TcALDH1) (EC 1.2.1.5) (Trans-chrysanthemic acid synthase) (EC 1.2.1.-) | MSSGANGNSKSLAYDIKFTKLFINGEFVDSISGSTFETIDPATEEVLATVAEGREEDVDLAVKAAREAFDNGPWPRLSGEARRKILLKFADLIEENADEIATLEVIDTGKPFQIARYVENSWTSETFRYFAGAADKIRGATLKMSSDFQAYTLREPIGVVGHIIPWNAPAYLFAMKVAPALAAGCTVVIKPAENTPLVGLFMAYLSKLAGVPDGVINVVNGFGSTAGAAVSSHMDIDAVTFTGSTKVGRTIMQAAAASNLKPVSLELGGKSPFIVFDDADIEKAAEIAVLGVLSNKGELCVAGSRVFVHEGIYDAFVKKL... | Component of the monoterpenoid pyrethrins biosynthesis pyrethrins are widely used plant-derived pesticide. Mediates the conversion of trans-chrysanthemal into trans-chrysanthemic acid. Can also use octanal, hept-2-enal, dodecanal, citral, farnesal, citronellal and perillyl aldehyde as substrates. |
A0A2J6L8Y7 | IF4E1_LACSA | Eukaryotic translation initiation factor 4E-1 (Ls-eIF4E-1) (eIF-4E-1) (eIF-4F 25 kDa subunit) (eIF-4F p26 subunit) (mRNA cap-binding protein) | MVEEIMKSEEQKLIDVNKHRGVRSDGEEDEQLEEGEIVGGDADTLSSSSSSRPGTAIAQHPLEHSWTFWFDTPSAKSKQVAWGSSMRPIYTFSSVEEFWSLYNNIHRPSKLAQGADFYCFKNKIEPKWEDPVCANGGKWTMTFTKAKSDTCWLYTLLAMIGEQFDHGDDICGAVVNVRARQEKIALWTKNAANESAQLSIGKQWKEFIDYNDTIGFIFHEDAKTLDRSAKNKYTV | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of prote... |
A0A2J8C362 | CUTI1_VERDA | Cutinase 11 (EC 3.1.1.74) (VdCUT11) | MQTSALLLAAQALVASAGLIERQSCPSIHVFGARETTVGPGYGSAGTVVNLILNAYPGSTAEAIVYPACGGQSSCGGISYGNSAMQGTNAVASAVNSFNQRCPNTQIVLVGYSQGGQIMDNALCGGGDPGSGITNTAVPLTASAVTAVKAAILMGSPRYRAGFPYNVGTCTAQGFAARPAGFVCPSGSKIQNYCDSPDPYCCTGNNQAVHQGYGGVYGQAALTFVRSKLNSGGSPPTTPPTTPPTTPPTTPPTTPPPSGSCAALYGQCGGQGWNGATCCSQGTCRASNQWYSQCL | Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. May degrade cutin, a macromolecule that forms the structure of the plant cuticle. May also degrade suberin, a specialized macromolecule found in the cell wall of various plant tissues. Allows pathogenic fungi to penetrate throug... |
A0A2K1ZPK4 | NRP32_POPTR | Metal transporter Nramp3.2 (PotriNRAMP3.2) (PtNRAMP3.2) (Natural resistance-associated macrophage protein 3.2) | MPVEENYQPLLQEEEERAYDSDEKVLIIGVDSDTESGGSTVLPPFSWKKLWLFTGPGFLMSIAFLDPGNLEGDLQAGAIAGYSLLWLLLWATAMGLLVQLLSARLGVATGRHLAELCREEYPTWASMVLWIMAELALIGADIQEVIGSAIAIKILSNGFVPLWAGVTITACDCFIFLFLENYGVRKLEAVFAVLIGIMAVTFGWMFADAKPSASELFLGILIPKLSSRTIQQAVGVVGCIIMPHNVFLHSALVQSREIDHNKKDRVQEALRYYSIESTTALVISFVINLFVTTVFAKGFYGTELANSIGLVNAGQYLQDK... | Divalent metal transporter. Can transport manganese (Mn) and iron (Fe). Involved in the release of metals stored in the vacuole. |
A0A2K3D5Z7 | CMD1_CHLRE | 5-methylcytosine-modifying enzyme 1 (5mC-modifying enzyme 1) (EC 1.14.99.-) (Ten-eleven translocation 1 gene protein homolog) (CrTET1) | MSVALASEYQLVQNAQLPQRWSQSARKSLAILEATARKEATAQMEAAGGSFCGQFPVDPAFKVLSLEYSAPNPDIARAIRRVDSVPNPPLPSHVVAIQSTAVDADLSLAMGVSLTPGRHTSYLVDARALQQSNSAAVAARKADGDKWGPACDEMFRGCRCVTGQEVVFYTAVKEPAGEVEGGEGSLFKPSFDGPAFRPSWGELSGKATGVVACVLQVPIGKETDIICAEYDNLVSKGQFATVDRFGGDHTVNMTGNALIQNDGKAISKGYAVAHRARVTSNVYGKANDVSLQRLAETVWSVVEKRLSFMPAYRDLVITEQ... | Dioxygenase that catalyzes DNA modification by mediating the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-glyceryl-methylcytosine (5gmC). Catalyzes the conjugation of a glyceryl moiety from L-ascorbate (vitamin C) to the methyl group of 5mC through a carbon-carbon bond. 5gmC DNA modification ma... |
A0A2K3DU55 | PGPP1_CHLRE | Phosphatidylglycerophosphate phosphatase 1, chloroplastic (CrPGPP1) (PGP phosphatase 1) (EC 3.1.3.27) | MRSVPGPSPPCTRSLAHSCRAAARGPCGSARPRARSVSARAHSSEASDMARVQQNFNSAGVGLFFSLFGGNQSLALPHLAAPDIRHVDWRALKAAGFKGLVFDKDNTLSLPFALEVEPRLQPALAGCLEAFGGRAVLYSNSAGLQQYDPEGKEAAALEAALGIPVLRHADKKPGGGCAELEAHFGCPAPQLIMVGDRYLTDIAFGNRHGMLTVHVQPLTTSGEPFGVVMARRIEEFWVARWTSFGVHPPAHSLAPHDTLAAYVKDQPIA | Phosphatidylglycerophosphate phosphatase involved in the biosynthesis of phosphatidylglycerol (PG), a phosphoglycerolipid predominantly present in chloroplastic thylakoid membranes and which has important photosynthetic function. Required for thylakoid membranes development and chloroplast function (By similarity). |
A0A2K3DZC4 | BSD2_CHLRE | Protein BUNDLE SHEATH DEFECTIVE 2, chloroplastic (CrBSD2) | MNSAALNARTASVAPQPQACHACKCRQLLSRRVPPAQRQVECSAIAPETLQDIIVGGAVVGAVSVALYAGLKKDPVPCSLCQGTGGIRCFACGGDGRNATVSRDDLYDSKALGGGVAPPKRDPLGRTINPRDCKVCRGAGLVLCSQCKGTGFQSAF | Chloroplast chaperone required for RuBisCo biogenesis and translational regulation of the RuBisCo large subunit (RbcL). Stabilizes an end-state assembly intermediate of eight RbcL subunits until the small subunits (RBCSs) become available to produce a complete stable RuBisCo complex containing eight small and eight lar... |
A0A2K5EJU6 | APOA1_AOTNA | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I] | MKAAVLIWLFLMGSQARHFWQQDEPPQSPWDRVKDLATVYVDSVKDSGRDYVSQFETSTLGKQLNLKLLDNWDSLTSTVNKLREQLGPVTQEFWDNLEKETEELRQEMSKDLEEVKAQVQPYLDNFQKNWQEEMNLYSQKLEPLRTELQEGALQKLQDLQEKLSPLAEQVRDRARAHVNTLRTQLAPYSDELRQRLATRLEALKENSGASLAEYHAKASEHLSALGEKAKPALDDLRQGLLPVLESFKVSFLSALEEYTKKLSSQ | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. |
A0A2K5QCI5 | APOA1_CEBIM | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I] | MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDSVKDSGRDYVSQFESSALGKQLNLKLLDNWDSLTSTVNKLREDLGPVTQEFWDNLEKETGWLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEVKLYSQKLEPLRTEFQEGALQKLQDLQEKLSPLAEQVRDRARAHVDTLRTQLAPYSDELRQRLATRLEVLKESGGASLAEYHAKASEHLSALGEKAKPALEDLRQGLLPVLESFKVSFLSALEEYAKKLSSQ | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. |
A0A2K5TU92 | SIR6_MACFA | NAD-dependent protein deacylase sirtuin-6 (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-6) (EC 2.3.1.286) (Protein mono-ADP-ribosyltransferase sirtuin-6) (EC 2.4.2.-) | MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSHVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPHVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGSCLEPC... | NAD-dependent protein deacetylase, deacylase and mono-ADP-ribosyltransferase that plays an essential role in DNA damage repair, telomere maintenance, metabolic homeostasis, inflammation, tumorigenesis and aging. Displays protein-lysine deacetylase or defatty-acylase (demyristoylase and depalmitoylase) activity, dependi... |
A0A2K6TRM6 | APOA1_SAIBB | Apolipoprotein A-I (Apo-AI) (ApoA-I) (Apolipoprotein A1) [Cleaved into: Proapolipoprotein A-I (ProapoA-I); Truncated apolipoprotein A-I] | MKAVVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDSVKESGKDYVSQFETSALGKQLNLKLLDNWDSLTSTVNKLREQLGPVTQEFWDNLEKETEQLRQEMNKDLEEVKAKVQPYLDDFQKKWQEEMNLYSQKLEPLRTEFQEGAFQKLQDLREKLRPVAEQVRDRARAHVDTLRTQLAPYSDELRQRLATRLEALKESGATLAEYQAKASEHLSALGEKAKPAFEDLRQGLLPVLESFKVSFLSALDEYAKKLSSQ | Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. |
A0A2K8FQU5 | TAT_CATRO | Tabersonine-19-hydroxy-O-acetyltransferase (EC 2.3.1.-) | MASKMVEIVSKMFIKPSSPTPQSLRRYNLSSIDQTIDSEVTSLAFFYTYNPSHESSKIGDLLKNSLSKTLVSYYQFAGRLIENDYIDCNDEGVEFVEVRIHGRMNDILKRGKSFATDLVLPTRIIALHEDSLLIVQLSHFDCGGIAIGFGASHKVSDGVSNVMFMKDWASSTSLSTFHKPTPLLTADSIFPPEDNKLLSNKSIVSFQQCLGKRFVFSTEAIEKLKSKAIEYGIQKPSRVEVVTAFLCQCAANCDLPRKKPYAIISAVNLRPYLALPQNSIGNIFSFYFCINDEGMDNQFSALISKLRNGKQKLLENIISK... | Component of the monoterpenoid indole alkaloids (MIAs, e.g. echitovenine, tabersonine, lochnericine, 19-hydroxytabersonine and horhammericine) biosynthetic pathway MIAs are used in cancer treatment and other medical applications. Acyltransferase catalyzing the conversion of horhammericine to 19-O-acetylhorhammericine, ... |
A0A2K9RFZ2 | TPS2_VITAC | Class I diterpene synthase 2, chloroplastic (VacTPS2) ((13S)-vitexifolin A synthase) (EC 4.2.3.-) (9,13-epoxylabda-14-ene synthase) (EC 4.2.3.189) (Viteagnusin D synthase) (EC 4.2.3.-) | MSLRFNLIVTPFSNHRIRNRRETFPAQEFPVATSKSAVKVKCNLITSTDLVGKVREKINGKVDNSLEVPAIHPVDIPSNLCMIDTLERLGVDRYFQSEIDGVLEETYRLWQQKEKDIFADVTCRAMAFRLLRVKGYEVSSDELAPYADQAHVNLQISDVTAVIELYRASQERIYEEESTLEKLHAWTSTYLKQQLVSGTISDKKLHKQVEYYLKNYHGILDLVGIRRSLDLYDIDHYQILKAADRFRTICKDLLAFSRQDFNNCQAQYQRELQLLQRWYEDCRLDKLNYGRDVLRISYFVSSAIIGDPELSDARLAFAKY... | Involved in the biosynthesis of labdane-type diterpenoid including cleroda-dienols, and peregrinol lactones and furan derivatives, dopaminergic diterpenoids that can bind to dopamine receptors in the human pituitary gland, have probably ability to lower prolactin levels, and are used to treat menstrual cycle disorders ... |
A0A2L0ART2 | TXF1A_SCOMU | Mu-scoloptoxin(15)-Ssm1a (Mu-SLPTX(15)-Ssm1a) (Potassium channel toxin SsTx) (Ssm spooky toxin) | MEKKIIFLVFLVALLALPGFISTEVIKKDTPYKKRKFPYKSECLKACATSFTGGDESRIQEGKPGFFKCTCYFTTG | Blocks voltage-gated potassium channels Kv7.4/KCNQ4 (IC(50)=2.5 uM), Kv7.1/KCNQ1 (IC(50)=2.8 uM), Kv7.2/KCNQ2 (IC(50)=2.7 uM) and Kv7.5/KCNQ5 (IC(50)=2.7 uM). Targets the pore domain, in particular negatively charged residues 'Asp-266' and 'Asp-288', of KCNQ4 and probably other KCNQ channel family members where these r... |
A0A2L0VXR5 | PLE4_CLIPA | Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (GGS) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10) ... | MRIPNVFLSYLRQVAVDGTLSSCSGVKSRKPVIAYGFDDSQDSLVDENDEKILEPFGYYRHLLKGKSARTVLMHCFNAFLGLPEDWVIGVTKAIEDLHNASLLIDDIEDESALRRGSPAAHMKYGIALTMNAGNLVYFTVLQDVYDLGMKTGGTQVANAMARIYTEEMIELHRGQGIEIWWRDQRSPPSVDQYIHMLEQKTGGLLRLGVRLLQCHPGVNNRADLSDIALRIGVYYQLRDDYINLMSTSYHDERGFAEDMTEGKYTFPMLHSLKRSPDSGLREILDLKPADIALKKKAIAIMQDTGSLVATRNLLGAVKND... | Geranylgeranyl pyrophosphate synthase part of the gene cluster that mediates the biosynthesis of pleuromutilin, a tricyclic diterpene showing antibacterial properties. The geranylgeranyl diphosphate (GGPP) synthase catalyzes the first step in pleuromutilin biosynthesis. GGPP is then substrate of the premutilin synthase... |
A0A2L2DDD0 | FIG02_BOARA | Figainin 2 (Br22) | MAFLKKSLFLVLFLGIVSLSVCEEEKREGEEKEEKREEEEGKEENEDGNEEHKEKRFLGAILKIGHALAKTVLPMVTNAFKPKQ | Antimicrobial peptide that displays antibacterial, antiprotozoal, and antiviral activity. Exhibits antibacterial activity against the Gram-positive bacteria S.epidermidis ATCC 12228 (MIC=4 uM), E.casseliflavus ATCC 700327 (MIC=4 uM), S.aureus ATCC 25923 (MIC=8 uM) and E.faecalis ATCC 29212 (MIC=8 uM), and the Gram-nega... |
A0A2L2DDE6 | FIG01_BOARA | Figainin 1 (Br24) | MAFLKKSLFLVLFLGLVSLSIGEEEKREEEEKNEEGANQEENAENKEKRFIGTLIPLALGALTKLFKG | Antimicrobial peptide that displays antibacterial and antiprotozoal activity. Exhibits antibacterial activity against the Gram-positive bacteria S.epidermidis ATCC 12228 (MIC=2 uM), E.casseliflavus ATCC 700327 (MIC=16 uM), S.aureus ATCC 25923 (MIC=4 uM) and E.faecalis ATCC 29212 (MIC=8 uM), and the Gram-negative bacter... |
A0A2N6JFX7 | TRTA_HERS1 | Triuret hydrolase TrtA (EC 3.5.1.-) (Cysteine hydrolase) | MIRIDATPYPYQFHPRSTALVVIDMQRDFIEEGGFGSALGNDVRPLAAIVPTVAALLQLAREAGMLVVHTRESHLPDLSDCPRSKRLRGNPTLGIGDVGPMGRILVQGEPGNQILPQLAPVEGELVIDKPGKGAFYATDLHAQLQERRITHLLVAGVTTEVCVQTSMREANDRGYECLVIEDACASYFPDFHRITLEMLTAQGGIVGWRTPLAQLQAGVAAYTGENP | Involved in the degradation of triuret (carbonyldiurea), an impurity in agricultural urea fertilizer, and an intermediate of uric acid oxidation endogenously found in human urine and in prokaryotic metabolism. Catalyzes the hydrolysis of triuret to 1-carboxybiuret and ammonia. The product, carboxybiuret, channels into ... |
A0A2P1GIW2 | CS_CATRO | Catharanthine synthase (EC 4.-.-.-) (Hydrolase 1) (CrHL1) | MNSSTDPTSDETIWDLSPYIKIFKDGRVERLHNSPYVPPSLNDPETGVSWKDVPISSQVSARVYIPKISDHEKLPIFVYVHGAGFCLESAFRSFFHTFVKHFVAETKVIGVSIEYRLAPEHLLPAAYEDCWEALQWVASHVGLDNSGLKTAIDKDPWIINYGDFDRLYLAGDSPGANIVHNTLIRAGKEKLKGGVKILGAILYYPYFIIPTSTKLSDDFEYNYTCYWKLAYPNAPGGMNNPMINPIAENAPDLAGYGCSRLLVTLVSMISTTPDETKDINAVYIEALEKSGWKGELEVADFDADYFELFTLETEMGKNMF... | Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to catharanthine. |
A0A2P1GIW3 | TS_CATRO | Tabersonine synthase (EC 4.-.-.-) (Hydrolase 2) (CrHL2) | MGSSDETIFDLPPYIKVFKDGRVERLHSSPYVPPSLNDPETGGVSWKDVPISSVVSARIYLPKINNHDEKLPIIVYFHGAGFCLESAFKSFFHTYVKHFVAEAKAIAVSVEFRLAPENHLPAAYEDCWEALQWVASHVGLDISSLKTCIDKDPWIINYADFDRLYLWGDSTGANIVHNTLIRSGKEKLNGGKVKILGAILYYPYFLIRTSSKQSDYMENEYRSYWKLAYPDAPGGNDNPMINPTAENAPDLAGYGCSRLLISMVADEARDITLLYIDALEKSGWKGELDVADFDKQYFELFEMETEVAKNMLRRLASFIK | Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to tabersonine, a precursor of vindoline. |
A0A2R2JFI5 | OPHMA_OMPOL | Methyltransferase/ribosomally synthesized cyclic peptide omphalotin A precursor ophMA (Omphalotin A biosynthesis cluster protein MA) [Cleaved into: N-methyltranferase ophM (EC 2.1.1.-); Ribosomally synthesized omphalotin core peptide; Follower peptide] | METSTQTKAGSLTIVGTGIESIGQMTLQALSYIEAAAKVFYCVIDPATEAFILTKNKNCVDLYQYYDNGKSRLNTYTQMSELMVREVRKGLDVVGVFYGHPGVFVNPSHRALAIAKSEGYRARMLPGVSAEDCLFADLCIDPSNPGCLTYEASDFLIRDRPVSIHSHLVLFQVGCVGIADFNFTGFDNNKFGVLVDRLEQEYGAEHPVVHYIAAMMPHQDPVTDKYTVAQLREPEIAKRVGGVSTFYIPPKARKASNLDIIRRLELLPAGQVPDKKARIYPANQWEPDVPEVEPYRPSDQAAIAQLADHAPPEQYQPLAT... | Fusion protein of the methyltransferase ophM and the omphalotin core peptide part of the gene cluster that mediates the biosynthesis of omphalotin A, a highly methylated cyclic dodecapeptide with nematodicidal activity. Omphalotin A derives from the C-terminus of the ophMA protein, and it is the ophMA protein that meth... |
A0A2R4QKX7 | TPS3_PIPNI | Terpene synthase 3 (PnTPS3) (Copaene synthase) (PnCop) (EC 4.2.3.133) (Germacrene D synthase) (PnGDS) (EC 4.2.3.-) | MGFSFVTNAAIAAHMPPSKQEIIRRDAKFHPTIWGDHFIQYLDTPIDPPQKVVERMEELKKQVRAMLRDTNLDISLIDWIQRTGIAYHFEEQIAETLKHVYEASTLTTDSSKYLEHFDLRHIALRFRLSRQQGYHASTDVFKRFMDEGDKFKQSIANDIEGMLSLYEASFMSVKGEAILDEALAFTGKNLEATLPNLTGSLAQQVECALEIPLRRCTDLVKARRSISCYENKNGRNEVVLELAKLDFNLLQAVHQRELALLTSWWNELGASTNLPFTRNRVVELYFWVLEVLSKPEHARAREIMVKSIIMASILDDVYDV... | Sesquiterpene synthase involved in the biosynthesis of volatile compounds that contribute to the characteristic flavors of black pepper. Mediates the conversion of (2E,6E)-farnesyl diphosphate (FPP) into alpha-copaene and germacrene D. |
A0A2R8Q1W5 | KEP1B_DANRE | Kelch-like ECH-associated protein 1B | MTECKAEVTPSASNGHRVFSYTLESHTAAAFAIMNELRRERQLCDVTLRVRYCPLDTHVDFVAHKVVLASSSPVFRAMFTNGLKECGMEVVPIEGIHPKVMGRLIEFAYTASISVGEKCVIHVMNGAVMYQIDSVVQACCDFLVEQLDPSNAIGIASFAEQIGCTELHQKAREYIYMNFSQVATQEEFFTLSHCQLVTLISRDELNVRCESEVFHACVAWVQYDREERRPYVQALLQAVRCHSLTPHFLQRQLEHFEWDAQSKDYLSQIFRDLTLHKPTKVIPLRTPKVPQLIYTVGGYFRQSLSFLEAFNPCSGAWLRL... | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradat... |
A0A2R8QCI3 | DAPLE_DANRE | Protein Daple (Coiled-coil domain-containing protein 88C) | MDITVSELMSNFMDSPLVVWVKTFGPLGFSSEDKLSMFMDLVDGVFLHKIMTHIDPSPMNQRVNKQVNNDVNLRIQNLNTVIRHIKNYYQEHLQQLIVMNLPNVLAIAKDPLSGKSMEEMKRMLLLILGCAVQCDRKEEIIEKIKLLDIETQAAIVTHIQEVTHNQENVLDLQWMEVAEIPAEQLDPLSRTMAFHLRKLIDERDESAELVIELTQERDYLQSQQPSGLLGFPSPERTSLSPITLLSKEDRQHLAVELADTKAKLRRSRQELEEKTEQLIDAKNEIERLDSDIQKLKQENTQLLAEARSVRAYRDEVDSLR... | Positive regulator of Wnt signaling, acting synergistically with dvl2 (By similarity). Functions upstream of ctnnb1/beta-catenin in the canonical Wnt pathway, and also activates jnk in the Wnt/planar cell polarity (PCP) pathway (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to an... |
A0A2R8VHR8 | DT3UO_MOUSE | DDIT3 upstream open reading frame protein (Alternative DDIT3 proteins) (AltDDIT3) | MLKMSGWQRQSQNNSRNLRRECSRRKCIFIHHHT | [Isoform AltDDIT3]: Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. |
A0A2R9YJI3 | GPR22_DANRE | G-protein coupled receptor 22 | MESMPSSLTHQRFGLLNKHLTRTGNTREGRMHTPPVLGFQAIMSNVTVLDNIEPLDFEMDLKTPYPVSFQVSLTGFLMLEIVLGLSSNLTVLALYCMKSNLVSSVSNIVTMNLHVLDVLVCVGCIPLTIVVVLLPLEGNNALICCFHEACVSFASVATAANVLAITLDRYDISVRPANRVLTMGRAVALLGSIWALSFFSFLVPFIEEGFFSQAGNERNQTEAEEPSNEYYTELGLYYHLLAQIPIFFFTAVVMLVTYYKILQALNIRIGTRFHSVPKKKPRKKKTISMTSTQPESTDASQSSAGRNAPLGMRTSVSVII... | Orphan G-protein coupled receptor that regulates cilia length and structure in the Kupffer's vesicle leading to the left-right asymmetry development by establishing a directional fluid flow. |
A0A2S1XB67 | ASO_CATRO | O-acetylstemmadenine oxidase (CrASO) (EC 1.21.3.-) (Precondylocarpine acetate synthase) | MIKKVPIVLSIFCFLLLLSSSHGSIPEAFLNCISNKFSLDVSILNILHVPSNSSYDSVLKSTIQNPRFLKSPKPLAIITPVLHSHVQSAVICTKQAGLQIRIRSGGADYEGLSYRSEVPFILLDLQNLRSISVDIEDNSAWVESGATIGEFYHEIAQNSPVHAFPAGVSSSVGIGGHLSSGGFGTLLRKYGLAADNIIDAKIVDARGRILDRESMGEDLFWAIRGGGGASFGVIVSWKVKLVKVPPMVTVFILSKTYEEGGLDLLHKWQYIEHKLPEDLFLAVSIMDDSSSGNKTLMAGFMSLFLGKTEDLLKVMAENFP... | Component of the seco-iridoid and derivatives monoterpenoid indole alkaloids (MIAs, e.g. vinblastine, catharanthine, tabersonine, vincadifformine, vindoline, vincristine, quinine and strychnine) biosynthesis pathway. Converts O-acetylstemmadenine (OAS) to reactive acetylated intermediates, likely dihydroprecondylocarpi... |
A0A2S3R7M0 | MARTX_VIBVL | Multifunctional-autoprocessing repeats-in-toxin (MARTX) (EC 3.4.22.-) [Cleaved into: Actin cross-linking toxin F1 (EC 6.3.2.-); N-epsilon-fatty acyltransferase F2 (EC 2.3.1.-) (Rho inactivation domain-containing toxin F2) (RIDvc); ABH effector region toxin F5; Cysteine protease domain-containing toxin F3 (EC 3.4.22.-)] | MGKPFWRSVEYFFTGNYSADDGNNSIVAIGFGGEIHAYGGDDHVTVGSIGATVYTGSGNDTVVGGSAYLRVEDTTGHLSVKGAAGYADINKSGDGNVSFAGAAGGVSIDHLGNNGDVSYGGAAAYNGITRKGLSGNVTFKGAGGYNALWHETNQGNLSFAGAGAGNKLDRTWFNRYQGSRGDVTFDGAGAANSISSRVETGNITFRGAGADNHLVRKGKVGDITLQGAGASNRIERTRQAEDVYAQTRGNIRFEGVGGYNSLYSDVAHGDIHFSGGGAYNTITRKGSGSSFDAQGMEYAKAEDIVLTAAQMHGLSIDNGN... | [Multifunctional-autoprocessing repeats-in-toxin]: Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis m... |
A0A2S4N3N0 | OMPA_SHIFL | Outer membrane protein A (Outer membrane porin A) | MKKTAIAIAVALAGFATVAQAAPKDNTWYTGAKLGWSQYHDTGFIPNNGPTHENQLGAGAFGGYQVNPYVGFEMGYDWLGRMPYKGDNINGAYKAQGVQLTAKLGYPITDDLDIYTRLGGMVWRADTKANVPGGASFKDHDTGVSPVFAGGVEYAITPEIATRLEYQWTNNIGDANTIGTRPDNGLLSLGVSYRFGQGEAAPVVAPAPAPEVQTKHFTLKSDVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRA... | With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes an internal gate slows down solute passage. {ECO:0000255|HAMAP-Rule:MF_00842}. Required for conjugation with F-type plasmids pr... |
A0A2T4VDM4 | GSDM_VITXG | Gasdermin bGSDM (bGSDM) (Bacterial gasdermin) [Cleaved into: Gasdermin bGSDM, N-terminus] | MGLCSDPAITYLKRLGYNVVRLPREGIQPLHLLGQQRGTVEYLGSLEKLITQPPSEPPAITRDQAAAGINGQKTENLSFSIGINILKSVLAQFGAGAGIEAQYNQARKVRFEFSNVLADSVEPLAVGQFLKMAEVDADNPVLKQYVLGNGRLYVITQVIKSNEFTVAAEKSGGGSIQLDVPEIQKVVGGKLKVEASVSSQSTVTYKGEKQLVFGFKCFEIGVKNGEITLFASQPGAIAMALDAAGGVMPSDSALLDEGGLLDLEGF | [Gasdermin bGSDM]: Precursor of a pore-forming protein involved in defense against bacteriophages (By similarity). Expression of bGSDM and the neighboring protease gene (Ga0334635_1659) is toxic in E.coli. Cleavage of this precursor by its dedicated protease releases the active moiety (gasdermin bGSDM, N-terminus) whic... |
A0A2T5Y4G4 | CAP12_SPHFK | CD-NTase-associated protein 12 (Cap12) (NAD(+) hydrolase) (EC 3.2.2.5) (TIR-STING) (SfSTING) | MKKRIFIGSSSEQLTILNEIVDLLGDDVECIPWTDAFALNKSGLDSLIKQTRLADYSILIATKDDLTKQRGESLTKPRDNVVFEFGLFLGAAGPEKCYLIAEEDTDLPTDLDGITVAKFTRNSGQYNSLDKIVESIRTHLVKIAEMSQLGLLPSTALAIGYYNSFIKRVCEEIHGSECVELEGKKIKVKSFRVDVVIPETLDDNGVGNFTTLYNKRYGLSKATTCTNPALLGTRGFPFHFKVDPPDANQESPVDIHLLDIPSTLSTIVESLKLYLPSNQVGQDFDMDYLEMRELENFAKVLKYLIGRNAATKGYVNVLTN... | CBASS (cyclic oligonucleotide-based antiphage signaling system) provides immunity against bacteriophage. The CD-NTase protein synthesizes cyclic nucleotides in response to infection these serve as specific second messenger signals. The signals activate a diverse range of effectors, leading to bacterial cell death and t... |
A0A2U1LIM9 | NCPR1_ARTAN | NADPH--cytochrome P450 reductase 1 (CPR 1) (P450R 1) (EC 1.6.2.4) | MQSTTSVKLSPFDLMTALLNGKVSFDTSNTSDTNIPLAVFMENRELLMILTTSVAVLIGCVVVLVWRRSSSAAKKAAESPVIVVPKKVTEDEVDDGRKKVTVFFGTQTGTAEGFAKALVEEAKARYEKAVFKVIDLDDYAAEDDEYEEKLKKESLAFFFLATYGDGEPTDNAARFYKWFTEGEEKGEWLEKLQYAVFGLGNRQYEHFNKIAKVVDEKLVEQGAKRLVPVGMGDDDQCIEDDFTAWKELVWPELDQLLRDEDDTSVATPYTAAVAEYRVVFHDKPETYDQDQLTNGHAVHDAQHPCRSNVAVKKELHSPLS... | This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes (By similarity). It can also provide electron transfer to heme oxygenase and cytochrome B5 (By similarity). Involved in the biosynthesis of the antimalarial endoperoxide artemisinin. Acts as a redox partner for CYP71AV1 which catal... |
A0A2U8QPE6 | OXLA_MICMP | L-amino acid oxidase (LAO) (MipLAAO1) (EC 1.4.3.2) | MNVFFMFSLVFLAAFGSCADDTRPLGECFREADYEEFLEIARNGLKKTSNPKHVVVVGAGMSGLSAAYVLAKAGHKVTLLEASEGVGGRVKTYRNKQEGWYINLGPMRLPERHRIVREYIRKFHLPLSEFVQENENTWYYIKNIRKRVSEVKKNPDLFEYPVNPSEKGKSASQLYQESLEKVIDELKRTNCNHILNKYDTYSTKEYLIKEGNLSPGAVDMIGDLLNEDSSFYLSFIESLKSDDIFSYEKRFDEIVGGFDQLPISMYQAIAEMVHLNAQVIKIQHNAKKVIVTYQTPAKTLPSVTADYVIVCSTSRAARHI... | Catalyzes an oxidative deamination of predominantly hydrophobic and aromatic L-amino acids, thus producing hydrogen peroxide that may contribute to the diverse toxic effects of this enzyme. Shows activity on L-Leu, L-Trp, and L-Tyr. Is not active on L-His, L-Ser, L-Arg, L-Ala, L-Glu, L-Cys,L-Lys, L-Val, L-Ile, and L-Th... |
A0A2U9GGW3 | THS2_PAPSO | Thebaine synthase 2 (EC 4.2.99.24) | MAPLGVSGLVGKLSTELEVDCDAEKYYNMYKHGEDVKKAVPHLCVDVKIISGDPTSSGCIKEWNVNIDGKTIRSVEETTHDDETKTLRHRVFEGDVMKDFKKFDTIMVVNPKPDGNGCVVTRSIEYEKTNENSPTPFDYLQFGHQAIEDMNKYLRDSESN | Catalyzes the formation of thebaine from (7S)-salutaridinol 7-O-acetate at the expense of labile hydroxylated by-products, which are preferentially produced by spontaneous allylic elimination. No visible activity toward (7S)-salutaridinol (at pH 7). |
A0A2Z5D854 | C71Z4_PASSA | Xanthotoxol synthase (EC 1.14.14.-) (Cytochrome P450 CYP71AZ4) (Fraxetin synthase) (EC 1.14.14.-) | MDPAAIFLILAIPIASVYLLFYHKKRVNGLSSPPGPRGLPFIGHFYQIYKSECAHEYISNLSKQYGSLMTLHLGSVPALVVSSPKMAQEVLKTQDLVFCSRAQMTGSGKLSYNGLEMAFAPYGEHWRNVRKMCTLELFTQKRAQFNFRPVREDEVSRMVGRLSEAAAASEDVNAYECFTNFATSIISRVAFGKRYDEDNLGKEKFQRMVADIEAMFAAFFVSDFFPMFGWIDRLSGVKAVLDRNFNEMDTFYQELIDEHLKPDRPESLNGDLIDVMLKNKGSFLTMDSIKAILLNVFSGGIGTTGSALVFAMTALLRNQR... | Involved in the biosynthesis of coumarins and furanocoumarins (FCs), natural products required for defense responses against attacks by predators with potential medical and agroindustrial usages such as anticoagulant, rodenticide and artificial vanilla substitutes. Catalyzes the conversion of psoralen into xanthotoxol ... |
A0A2Z5XAU0 | PHM7_PYRSX | Diels-Alderase phm7 (EC 5.5.1.-) (Phomasetin biosynthesis cluster protein 7) | MSEPTSSSSLDITSNCIIETPLQPSDFLPKSANLFPKFPERISVDSWELWEFDTFDTNGSVAFGCSLYRDARGVEQGGFHAEVNALWPDGTHWGETLYFAVSEVVENSDGTTGGKWLSKDGGSITFHIASDYTAAALDFNVPGKVSGTMELRNHANVSPTSNLPASDAEAQLCPGVYYTFPMGPVATSVTATFSSVGANGESRELFISSGYGGMVRGWSARPWPTFMNDAYYVVAQVGPYMLQILRTLGSVFVQHKPFAVARLYLDGSLVSAANTVVGDELTAHADDVKGDAVRLTKVQPDEKSQGLSGKFRDGNVGYVL... | Diels-Alderase part of the gene cluster that mediates the biosynthesis of the trans-fused decalin-containing tetramic acid phomasetin, the stereochemical opposite of the HIV-1 integrase inhibitor equisetin. The PKS module of phm1 together with the enoylreductase phm4 catalyze the formation of the polyketide unit which ... |
A0A2Z5Z9X0 | ACT1_CRIJA | Deep-sea actinoporin Cjtox I (DELTA-actitoxin-Cja1a) (DELTA-AITX-Cja1a) | MNRLIILCLVAATIYSTIALPMKEDISNEERPTSVNEKPVKKSVAVAGAVIQGAALAFQVLDKILTSLGGIGRKIAIGVDNESGMKWAARNVYFYSGTSDTVLPYSVPHSKAFLYGARKTRGSVRGAVGVLAYSMSDGNTLGILFSVPYDYNWYSNWWNIKVYRGYKRANKWMYHDLYYYARPHKGNNEWHEKSLGYGLKSKGFMTSSGQTKLEIRVSRA | Probably acts in predation. Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cytolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjace... |
A0A336U966 | TYRP_ASPTE | Tyrosinase P (EC 1.14.18.-) | MGFYRNLVLVAASCTQALGLCPAPRCDSPDIRHEWGELSREDRLSYISAVQCMKDRPPELSVEEVPAVRSRYDDFTAVHINYTLQIHNSGIFLPWHRHFIWLWEKALREECGFTGTLPYWDWVMWPNLAASPLFDGTETSLSGDGEFNATEQPTELNPEPGLTITIPRGAGGGCVRTGPFKDWVINMGPFAFNESYEPALPDHAFDYNPRCLVRSLNDWVIQTYNNQTVVDTLLDSPDIVEFQNIMGGFPNPPIPIGPHAMGHRSLGPDMLDFFASPQDPAFWQHHGMVDRLWTVWQDADEPWRRFALNGSSTTWYKDDT... | Tyrosinase part of the gene cluster that mediates the biosynthesis of Asp-melanin, a pigment that confers resistance against UV light and hampers phagocytosis by soil amoeba. The nonribosomal peptide synthase melA converts 4-hydroxyphenylpyruvate (4-HPPA) to aspulvinone E. The tyrosinase tyrP then performs hydroxylatio... |
A0A343URW6 | TEX1_CATRO | Tabersonine 6,7-epoxidase isoform 1 (EC 1.14.14.-) (Cytochrome P450 71D521) | MEFVVSLFAFVVSCFILLKVAKNSKNPKRNTNLELPPGPKQLPIIGNLHQLGGGLAHHVLRNLGKQYGPLMHLKIGELSTIVVSSTEIAKEVFKTHDIHFSNRPSHILVFKIVSYDYKDIVLSQYGKYWRELRKVCNLELLSPNRVQSFRSIREDAVLNMMKSISSNDGKVVNLSEMILSLIYGITARAAFGVWSKKHEEFIRLESEIQRLATTFVLADMFPSIKFLGALSGLRYKVEKVHKKVDDILEGILKEHRRQNNNMTEENGKKDLVDVLLNIQKNGDMETPFTDQHIKAIIFDMFSAGTLTSTIAVDWAMAEMM... | Component of the monoterpenoid indole alkaloids (MIAs, e.g. echitovenine, tabersonine, lochnericine, 19-hydroxytabersonine and horhammericine) biosynthetic pathway MIAs are used in cancer treatment and other medical applications. Cytochrome P450 catalyzing the conversion of tabersonine to lochnericine. |
A0A383ZFX3 | ASAH1_BALAS | Acid ceramidase (AC) (ACDase) (Acid CDase) (EC 3.5.1.23) (Acylsphingosine deacylase) (N-acylethanolamine hydrolase ASAH1) (EC 3.5.1.-) (N-acylsphingosine amidohydrolase) [Cleaved into: Acid ceramidase subunit alpha; Acid ceramidase subunit beta] | MLGRSRLTFVLLSVTVTCSVAQHVPPWTEDCRKSTYPPSGPTYRGPVPWYTINLDLPPYKRWHELMVDKAPALKVIVNYLKNMINAFEPSGKIVQLVDQKLPGLLGSFPGPFEEEMKGIAAVTEIPLGEIILFNIFYEFFTICTSIITEDKEGHLLHARNMDFGVFLGWNVNNNTWVVTEELKPLTVNLDFQRNSKTVFKAAGFAGYVGMLTGFKPGLFSLTLNERFSTNGGFMGVIEWILGKKDAKWIGFIIRSVLENSTSYEEAKTILTKSKILAPAYFILGGSKSGEGCVITRDRVQSLDIYELDPKQGIWYVVQTN... | Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell... |
A0A384E129 | O16A_CONMB | Omega-conotoxin MoVIA [Cleaved into: Omega-conotoxin MoVIB] | MKLTCVVIVAVLFLTACQLITADDSRSTQRHRALRSTTKLSMSTRCKPPGSKCSPSMRDCCTTCISYTKRCRKYYN | [Omega-conotoxin MoVIA]: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin potently blocks mammalian N-type calcium channels (Cav2.2/CACNA1B) (IC(50)=330 nM on human channels). It is 9-fold more potent in displacing radiolabeled omega-conotoxin GVIA from... |
A0A386CAB9 | NLRP1_DANRE | NACHT, LRR and PYD domains-containing protein 1 homolog (EC 3.4.-.-) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)] | MSSDYTDRNNLASAIKTLGDMLEKDEAFQRLMYNASTKGEINRGRVNKVFLKALLSAGDKVGEFLNELIDHLNLFKVLGDFSWNPPVLKEAELNERTSQLRTQQHKYVERVSGFSHYGFGETGTPARGDITSPRGPQVASIEEDLATSKLAELLLAVGDHLEKIEKKGQFLPENVERFSLDCFITSESVKLSSEAVELAPCYTEPVIIQRSKEQTEKYCQEYVRSPHTSSHLLSNDKTQSIRIGQLFSPDSDGNTPKTVILCGDSGRGKSFVLEKIILDWVHLEHHFENFDAVFLLKYEELKCLSEEMSLTELLSRSCSL... | Acts as the sensor component of the nlrp1 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to subsequent pyroptosis. Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and pl... |
A0A386KZ50 | DABA_PSEMU | Magnesium-dependent glutamate N-prenyltransferase (EC 2.5.1.-) (Domoic acid biosynthesis cluster protein A) (PmDabA) | MKFATSIVAAIATTGAAFTVIPQKLSHPSQLNALNTMGSISSITAESPKEVLSRVQDAGLTLTNPNDLYWMVDFLKEKYYDNGDYYYPIKTVCDGESIDVKFYCPFEPSLSPHYLELYGSRDERASIYETTMKKYNRINSEKTSAICTPYSSYGDTQIVAYFYSMMYYINDQTAHLKLPESEIESELIDILNDDILIYLNEFMSIFEPEDAQDLERIWDFLDFYQPYFSKVDGKIVLDEKYLVRTPSQMPLIKTICEYVSEQFAPSKNITQVIWEVVRYIKGVKDEIHIRGDKSFTLSLQEYDDFRDKVTASPMAHAVSD... | Magnesium-dependent glutamate N-prenyltransferase: part of the gene cluster that mediates the biosynthesis of domoic acid (DA) and derivatives, natural products with neurochemical activity acting as ionotropic glutamate receptor (iGluR) agonists, thus being neurotoxins causing amnesic shellfish poisoning (ASP). Catalyz... |
A0A396GMX6 | DELA2_MEDTR | DELLA protein 2 (MtDELLA2) | MKREHKLEHEDMSSGSGKSGVCWEDDGGGMDELLAVVGYKVKSSDMAEVAQKLEQLEQAMMGNNFHDHDESTIAQHLSNDTVHYNPSDISNWLQTMLSNFDPQPNNPSVNSDDNDLNAIPGKAIYAADEFTSRKRVKRNESVTVTTESTTTRPIMVVETQEKGIRLVHSLMACAEAVEQNNLKMAEALVKQIGYLAVSQEGAMRKVATYFAEGLARRIYGVFPQHSVSDSLQIHFYETCPNLKFAHFTANQAILEAFQGKSSVHVIDFSINQGMQWPALMQALALRPGGPPAFRLTGIGPPASDNSDHLQQVGWRLAQFA... | Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway (By similarity). Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes (By similarity). Upon GA application, it is degraded by the proteasome, allowing the GA s... |
A0A396IUP1 | DELA1_MEDTR | DELLA protein 1 (MtDELLA1) | MKREHQESFGGGVISNNNKTNTNHLNSSKNINFGECSSMQNTNTKQNMWREEKETNGGGMDELLAALGYKVRSSDMADVAQKLEQLEMVMGSAQEEGINHLSSDTVHYDPTDLYSWVQTMLTELNPDSSQINDPLASLGSSSEILNNTFNDDSEYDLSAIPGMAAYPPQEENTAAKRMKTWSEPESEPAVVMSPPPAVENTRPVVLVDTQETGVRLVHTLMACAEAIQQKNLKLAEALVKHISLLASLQTGAMRKVASYFAQALARRIYGNPEETIDSSFSEILHMHFYESSPYLKFAHFTANQAILEAFAGAGRVHVID... | Probable transcriptional regulator that acts as a repressor of the gibberellin (GA) signaling pathway (By similarity). Probably acts by participating in large multiprotein complexes that repress transcription of GA-inducible genes (By similarity). Upon GA application, it is degraded by the proteasome, allowing the GA s... |
A0A396JG59 | EX70I_MEDTR | Exocyst complex component EXO70I (MtExo70I) (Exocyst subunit Exo70 family protein I) | MHKKQLMALLMVPQTSDSQDATITKLESAYSDLESLLRSSKQMEQNIETMETRFDLLHGSITTASRRVHPLQSLSMSRKALDTRINRAISPALALLETFKLAESLQNNLLNLSSKLSTEKTHQKRLSKLLDYMDCVDQLNEAINSISEVVEPVIMRLQEVVEFISRTKAADQYRTQRLREALITLKALYETEVDEMRFEGLLDQALLHMQDEFEVLLLKLKHRKLGDMSHMQNGGEDCDDHFEVSFELGSELEIEVLRRISNTLAANDCLDICIDIYVKVRYKRAAKALMKLNPDYLRTYTPEGIDEMEWENLETSITLW... | Component of an exocyst subcomplex specifically required for periarbuscular membrane (PAM) biogenesis during arbuscular mycorrhizal (AM) symbiosis with AM fungi (e.g. Glomus versiforme), especially critical during the early branching phase of arbuscule development probably involved in STR and STR2 delivery into the PAM... |
A0A3L7I2I8 | PLPL9_CRIGR | 85/88 kDa calcium-independent phospholipase A2 (CaI-PLA2) (EC 3.1.1.4) (2-lysophosphatidylcholine acylhydrolase) (EC 3.1.1.5) (Group VI phospholipase A2) (GVI PLA2) (Intracellular membrane-associated calcium-independent phospholipase A2 beta) (iPLA2-beta) (PLA2G6) (Palmitoyl-CoA hydrolase) (EC 3.1.2.2) (Patatin-like ph... | MQFFGRLVNTLSSVTNLFSNPFRVKEISVADYTSHERVREEGQLILFQNASNRTWDCILVSPRNPHSGFRLFQLESEADALVNFQQFSSQLPPFYESSVQVLHVEVLQHLSDLIRSHPSWTVTHLAVELGIRECFHHSRIISCANSTENEEGCTPLHLACRKGDSEILVELVQYCHAQMDVTDNKGETAFHYAVQGDNSQVLQLLGKNASAGLNQVNKQGLTPLHLACQMGKQEMVRVLLLCNARCNVMGPSGFPIHTAMKFSQKGCAEMIISMDSSQIHSKDPRYGASPLHWAKNAEMARMLLKRGCDVDSTSAAGNTA... | Calcium-independent phospholipase involved in phospholipid remodeling with implications in cellular membrane homeostasis, mitochondrial integrity and signal transduction. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity respectively),... |
A0A3Q0KDV9 | SEP10_SCHMA | Septin-10 (SmSEPT10) | MTADVLKALPPDVRTLKLSGHVGFDSLPDQLVNKAISQGFVFNILCVGETGIGKSTLLETLFNQKFDFSPSNHDLTDPKLKAVTYDLKEANVKLKLTVVETCGYGDQINKENNIKPVVDYIDNQFENYLQEELKMKRSMQAFHDTRVHVCLYFIAPTGHSLKSIDLVAMKKLENKVNVIPVIAKSDTITKSELQKFKARILSEIQSNEIGIYQFPTDDEAVSETNSVMNQHIPFAVVGSSEEVKINGKTVRVRQYPWGSVQVENENHCDFVRLREMLLRVNMEDLRERTHGVHYETYRRQRLIEMGFRDDEKMSLQETYE... | Filament-forming GTP-binding protein. Lacks GTPase activity, which is likely due to absence of an essential threonine residue important for hydrolytic activity in septins. May be involved in membrane remodeling, potentially by its nucleotide-dependent cellular membrane association/dissociation ability. Able to bind to ... |
A0A3Q0KR05 | NPRS_SCHMA | Beta-alanyl-bioamine nonribosomal peptide synthetase (EC 6.3.2.-) (Nonribosomal peptide synthetase) (SmNRPS) | MPQSTAQLKSPLLHTLLENLTQSSICTSTAIWHVPNPVNFVCNHNENSFDNKNNSVTTITTTDVSTNNHKNTNYDYEQQEQWSNEEINSNQESNEIYTMTFLKLNNAANRVAMNLANYLERKWSSITNKINRTQLNQHSLSIDEPIELRNQSDTVIALFMPPGIDRIVVQIACMKLHLAYMPLDRNVPAGRITQILHKLKPILILIDKDYYDFIYDDDHNDNDKMSDLSSSIDNNNKSLLSRKLSSNDFIIGNLNQLKLTFQLFDVKVYEYIKLMKLSKYYSRSDIYTASIPIRVCLFPFESDPIVLVLFTSGSTSSGPK... | Catalyzes the condensation of beta-alanine with tryptamine to form beta-alanyl-tryptamine (BATT). Beta-alanyl-tryptamine is an essential pheromone produced by the male that stimulates female sexual development during pairing. |
A0A3Q0NBH7 | PGDA_LISMG | Peptidoglycan-N-acetylglucosamine deacetylase PgdA (Peptidoglycan GlcNAc deacetylase) (EC 3.5.1.104) (N-acetylglucosamine de-N-acetylase PgdA) (Peptidoglycan N-deacetylase) (PG N-deacetylase) (Petptidoglycan deacetylase) (PG deacetylase) | MKIRWIRLSLVAILIIAVVFIGVIGFQKYQFSKSRNKVIMQMDRLMKDQDGGNFRRLDKKENGVEIISYIPKTTEKKDNEIIQKEIGKATDAEVKKLNRDKETQGIIFYTYQKHRMAEQAISYKAVQSEYVKEGRTKFVLKDKKDICKNIVTDAETGALLTLGEVLIKSNQTKLNLKTAVEEELIKTGDFSLKDVGNLGKIKSLVKWNQTDFEITNSEIILPVKIPGAPEPKKVKVKLADIASSVNKRYLPSSVKVPEVPKAKTNKRIALTFDDGPSSSVTPGVLDTLKRHNVKATFFVLGSSVIQNPGLVKRELEEGHQ... | Catalyzes the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan (PG). Deacetylates also N-acetylated PG. Does not deacetylate N-acetylmuramic acid. Confers host lysozyme resistance. Critical for virulence and escape from innate immune response of the host. Required for intracellular survival of ba... |
A0A3Q2TTB3 | PRIPO_CHICK | DNA-directed primase/polymerase protein (EC 2.7.7.-) | MKRKWEERVKKVEELASYYERNPLPTVYKPRLSKPLQPSRVWKIFCRQADAFRFVKTCKEDVHVFALERNTQNGQRFYLVTTYQELWYYYTKGYKTSLMHCYEVIPEKDACKLYFDLEFYKAANPGADGKDMVAKLIELVSQKLKELYDVNCSARDVLNLDSSTDEKFSRHLIFLPCKTVFKDNIHVGNFVRTILQPAIRLVGSNVAAPIAEGGAGYTSQCSAPTVELDGPLTNLTAVEDASKGWPAIADQRKETETSHHGENSEFSFLIVNNKEGDKQLFVDLGVYTRNRNFRMYKSSKAGKNVILTIAEDNKFVPNCE... | DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions. Shows a high c... |
A0A3Q7FGP1 | IF4E2_SOLLC | Eukaryotic translation initiation factor 4E-2 (eIF4E-2) (eIF-4F 25 kDa subunit) (eIF-4F p26 subunit) (mRNA cap-binding protein) | MADELNKAALEEYKSSSVEDRGEEGEIVGESDDTASSLGKQITMKHPLEHSWTFWFDNPSGKSKQAAWGSSIRPIYTFSTAEDFWSVYNNIHHPSKLAVGADFHCFKNKIEPKWEDPVCANGGKWTMNFSRGKSDTCWLYTLLALIGEQFDYGDEICGAVINVRVRQEKIALWTRNAANETAQVSIGKQWKEFLDYNDTIGFIFHDDAKKLDRAAKNRYSV | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of prote... |
A0A3Q7GYG2 | MOMT2_SOLLC | Myricetin 7/4'-O-methyltransferase 2 (SlMOMT2a) (SlMOMT2b) (EC 2.1.1.-) (3',4',5'-trimethyl myricetin 7-O-methyltransferase) (EC 2.1.1.-) (3',5'-dimethyl myricetin 7-O-methyltransferase) (7-O-methyl syringetin synthase) (Syringetin 7-O-methyltransferase) (EC 2.1.1.-) (3'-methyl quercetin 4'-O-methyltransferase) (4'-O-m... | MASNNNICAYELIEAEAQSWDYILSYLRPSCIKCAIQLGIPDILHKNADPIMSLSDLIAALPNLNPSKTTFIPILMRVLVDFGLFNYHQQQGDGYSLTTVGRLLVENHHFGNRSFFLFAQHPVVLNTAASVGDWLKDDLRTAFETADGKSHWDYCGADPEFNGVFNDAMAGDSRLMSNLLISDCCAGVFEGLTSLVDIGGGTGAVAMAIAGAFPSLKCIVLDLPHVIADRKGSGNLEFVAGSMFDKIPHANAILLKWILHNWDDEDCVKLLKKCKESISSRENGGKVIIIDMIMEDNYNNKQLVQSQHLMDLIMRITYAS... | Flavonoid 7/4'-O-methyltransferase involved in the biosynthesis of polymethoxylated flavonoids natural products such as myricetin derivatives, aroma compounds possessing antioxidant properties and exhibiting pharmacological activities such as anti-carcinogen, anti-viral, anti-thrombotic, anti-diabetic, anti-atheroscler... |
A0A3Q7HJG4 | CURE1_SOLLC | Cuscuta receptor 1 (CuRe1) (Leucine-rich repeat receptor-like protein Solyc08g016270) (LRR-RLP Solyc08g016270) | MGNIKFLLLVFFLIVVVVNGCWEEERNALLELQTNIMSSNGELLVDWAGYNAAHFVDCCFWDRVKCSLETGRVIKLDLEADFGTGDGWLFNASLFLPFKSLQVLLLSSQNIIGWTKNEGFSKLRQLPNLKEVDLQYNPIDPKVLLSSLCWISSLEVLKLGVDVDTSFSIPMTYNTNMMSKKCGGLSNLRELWFEGYEINDINILSALGELRNLEKLILDDNNFNSTIFSSLKIFPSLKHLNLAANEINGNVEMNDIIDLSNLEYLDLSDNNIHSFATTKGNKKMTSLRSLLLGSSYSNSSRVIRSLKSFSSLKSLSYKNS... | Involved in plant defense. Contributes to resistance against parasitic plant C.reflexa. Acts as a receptor for the 11 kDa glycine-rich protein (GRP) of C.reflexa inducing immune responses such as emission of stress-related phytohormone ethylene, reactive oxygen species (ROS) release, and hypersensitive cell death. Reco... |
A0A3Q7HRZ6 | MYC2_SOLLC | Transcription factor MYC2 (LeMYC2) (SlMYC2) (Basic helix-loop-helix protein 147) (Transcription factor bHLH147) (bHLH transcription factor bHLH147) | MTEYSLPTMNLWNNSTSDDNVSMMEAFMSSDLSFWATNNSTSAAVVGVNSNLPHASSNTPSVFAPSSSTSASTLSAAATVDASKSMPFFNQETLQQRLQALIDGARETWTYAIFWQSSVVDFSSPSVLGWGDGYYKGEEDKAKRKLSVSSPAYIAEQEHRKKVLRELNSLISGAPPGTDDAVDEEVTDTEWFFLISMTQSFVNGSGLPGQALYSSSPIWVAGTEKLAASHCERVRQAQGFGLQTIVCIPSANGVVELGSTELIVQSSDLMNKVRVLFNFSNDLGSGSWAVQPESDPSALWLTDPSSSGMEVRESLNTVQT... | Transcriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1. Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth. Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate ... |
A0A3Q7HYF0 | MOMT3_SOLLC | Myricetin 3-O-methyltransferase 3 (SlMOMT3) (EC 2.1.1.-) (3',4',5'-trimethyl myricetin 3-O-methyltransferase) (EC 2.1.1.-) (3',5'-dimethyl myricetin 3-O-methyltransferase) (Syringetin 3-O-methyltransferase) (EC 2.1.1.-) (3'-methyl myricetin 3-O-methyltransferase) (Laricitrin 3-O-methyltransferase) (EC 2.1.1.-) (3'-meth... | MALSMDNIVISNEEEIYMMKAMHIPCGLYLNMVLRAAIELDLFEIIAKSTTQKLSSYEIASQIPTKNPNASSLVLERILRFLASQSFLTCNITKNDDGNVHTSYNLTPLSQSLILDKDGTSIAPFLLLATDPVAVNSWFHFKDAILEGEIPFNKAHGVHAFEYHGKDSRFNGVFNKAMQNVTCIDMKRVLECYNGFEGVKEIIDVGGGLGISLASIISKYPNIKGINFDLPHVIKDAPTYEGIEHVGGDMFKSVPQRELILLKAILHDWDDECCVKILKNCWRALPKDGKVVVIEQMQPEYPEINLISKNSFSVDMLMMT... | Flavonoid 3-O-methyltransferase involved in the biosynthesis of polymethoxylated flavonoids natural products such as myricetin derivatives, aroma compounds possessing antioxidant properties and exhibiting pharmacological activities such as anti-carcinogen, anti-viral, anti-thrombotic, anti-diabetic, anti-atheroscleroti... |
A0A3Q7I7R4 | IFI4E_SOLLC | Eukaryotic translation initiation factor isoform 4E (SleIF(iso)4E) (eIF(iso)-4E) (eIF-(iso)4F 25 kDa subunit) (eIF-(iso)4F p28 subunit) (mRNA cap-binding protein) | MATEAPVEATEIPSVAAAETVEKQPHKLERKWTFWFDNQSKPKQGVAWGSSLRKAYTFETVEEFWSLYDQIFKPSKVTVNADFHLFKAGIEPKWEDPECANGGKWTATSSRKANLETMWLETLMALVGEQFDESEDICGVVASVRRSQDKLSLWTKTATNEAAQMGIGRKWKEIIDAEKISYSFHDDSKRERSAKSRYTV | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of prote... |
A0A3Q8GL18 | NEPS1_NEPRA | (+)-cis,trans-nepetalactol synthase NEPS1 (EC 5.5.1.34) (Nepetalactol-related short-chain dehydrogenase) (Nepetalactol dehydrogenase) (EC 1.1.1.419) (Nepetalactol-related short-chain reductase 1) (Nepetalactol-related SDR1) (NmNEPS1) | MASTANPMQVMKKKLEGKVVIVTGGASGIGQTAARVFAQHGARAVVIADIQSEVGKSVAKSIGDPCCYVQCDVSDEEEVKSMIEWTASAYGGLDMMFSNVGIMSKSAQTVMDLDLLEFDKVMRVNARGMAACLKHAARKMVELGTRGTIICTTTPLSSRGGQSMTDYAMSKHAVMGLVRSASIQLGAHGIRVNCVTPSVVLTPLAQRMGLATPDDFHTHFGNFTSLKGVYLTPEQVAEAVVYLASDDAAFITGHDLVLDGGLLCLPFFAPS | Bifunctional enzyme that possesses cyclase and dehydrogenase activities. Functions as a non-oxidoreductive cyclase to promote the formation of cis-trans-nepetalactol. Functions as dehydrogenase to oxidize cis-cis-nepetalactol and cis-trans-nepetalactol into nepetalactones, metabolites that are both insect-repellent and... |
A0A3S5YBC7 | EGCSE_RHOH1 | Endoglycoceramidase I (EGCase I) (EC 3.2.1.123) | MRKTVVAFAAAIAACSAVLSSTTTSAAPPATPITTLQADGTHLVDGYGRTVLLHGVNNVDKDAPYLPAGETLTPQDIDILVRHGFNTVRLGTSFDALMPQRGQIDEAYLDRLTGVVDALTARGMHVLLDNHQDGLSKAWGGNGFPEWAIESRPREWEPNPGFPLYYLMPSLNAGWDEVWGNTHGALDHLGTALGALAERVEGKPGVMGIELLNEPWPGSRFLSCFPNGCPDFDRTYQAAMQKLTDAVRAQNPTIPVYWEPNVTWNQMMPSNLFAPPVTPALTTADVVFAPHDYCIPSQLAIYLGLPQALRGLCVPQQDLT... | Hydrolyzes glycosphingolipids exhibits broad substrate specificity including monosialodihexosylganglioside (GM3), monosialotetrahexosylganglioside (GM1), fucosyl-GM1, lactosylceramide, globotriosylceramide, globotetraosylceramide, ganglioside GD1a, and ganglioside GD1b. No activity towards glucosylceramide and galactos... |
A0A3S7WQS5 | SPCS_LEIDO | O-phosphoseryl-tRNA(Sec) selenium transferase (EC 2.9.1.2) (Selenocysteine synthase) (Selenocysteinyl-tRNA(Sec) synthase) (Sep-tRNA:Sec-tRNA synthase) | MDDRSLKLAEDFVSARYIEAGRESLRATARIMRSILAQRCCPDEGLTDAAIELILRQLSLMDTNNLAHHVGGGEREGRVVSALVRMRHFHLTHGIGRSGDLFSEQPKAAGSSLLYKITNVLMLDLIRQAGAPSTAAAVVVPMATGMTLALVLRCVAKTHMKELMKEAEAVQLQRTVTKDSTSATSAAPVQEPPMSEADRDRHDRTSLPVPATPRYVIWPRIDQKTALKCIDAAGLVPVPVQLRPAVPLARSAAPCVSTNRDSLDRGQDSIGSPSTPTSSSSLFLECHVDDVAAAVNAVGGPSQVVCVLSTTSCFAPRLPD... | Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. |
A0A411EZW9 | PA21_AGKPL | Acidic phospholipase A2 AplTX-I (svPLA2) (EC 3.1.1.4) (Phosphatidylcholine 2-acylhydrolase) | MRTLWIMAVLLLGVEGDLMQFETLIMKIAKRSGMFWYSAYGCYCGWGGQGRPQDATDRCCFVHDCCYGKVTGCDPKLDSYTYSVENGDVVCGGNDPCKKEICECDRAAAICFRDNKVTYDNKYWRFPPQNCKEESEPC | Snake venom phospholipase A2 (PLA2) that triggers a high neuromuscular toxicity in chick biventer cervicis preparations, but not in mouse phrenic nerve-diaphragm (PND) preparations, suggesting a selective neurotoxin activity towards birds. Does not induce myotoxic, coagulant, anticoagulant, edema, and antibacterial act... |
A0A411MR89 | SZNF_STRC2 | Nitrosourea synthase (EC 1.14.13.250) (Multi-domain metalloenzyme SznF) | MSHVPPHVPFELSGAELRDAIVQYATNPIYHDNLDWLNHDNPYRRQLRPQVLPHLDYDKVPGRENILNYASLAVQRLLTSVYEADLVFFPKSGLKGKEEDFRAFYSPANRALGERIRPALERYAFGFLDDEVETSGTWTAQSLDAYLDSLDTAGGAEQSPVEKAILGSADRERAARMWLVQFAPDFLSEASPMMRNVLGYYGPAQSEWFKVVIDEYGYGVHDTKHSTLFERTLESVGLESDLHRYWQYYLNSSLLLNNYFHYLGKNHELFFRYVGALYYTESSLVDFCRRADHLLREVFGDTVDTTYFTEHIHIDQHHGR... | Involved in the biosynthesis of the glucosamine-nitrosourea antibiotic streptozotocin (SZN). Catalyzes a complex multi-step reaction: the overall reaction is an oxidative rearrangement of the guanidine group of N(omega)-methyl-L-arginine (L-NMA), generating an N-nitrosourea product. SznF first hydroxylates L-NMA to for... |
A0A445AGS0 | IFI4E_ARAHY | Eukaryotic translation initiation factor isoform 4E (PeaeIF(iso)4E) (eIF(iso)-4E) (eIF-(iso)4F 25 kDa subunit) (eIF-(iso)4F p28 subunit) (mRNA cap-binding protein) | MATETAGAVVESSSAATVPSPAPEAGSKHKLERKWTFWFDNQSKPKQGAAWGTSLREVYTFDTVEEFWCLYDQVFKPSKLPGNADFHLFKTGIEPKWEDPECAKGGKWTVTSNRKANLDNMWLETMMALIGEQFDDAEDICGVVASVRQRQDKLSLWTKTAANEAAQMGIGRKWKEIIDVTDKIIYNFHDDSRTRSSKSRYSV | Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of prote... |
A0A452E9Y6 | PERL_CAPHI | Lactoperoxidase (LPO) (EC 1.11.1.7) | MLVCLHLQVFLASVALFEVAASDTIAQAASTTTISDAVSKVKTQVNKAFLDSRTRLKTALSSEAPTTRQLSEYFKHAKGRTRTAIRNGQVWEESLKRLRRDTTLTNVTDPSLDLTALSWEVGCGAPVPLVKCDENSPYRTITGDCNNRRSPALGAANRALARWLPAEYEDGLAVPFGWTQRKTRNGFRVPLAREVSNKIVGYLDEEGVLDQNRSLLFMQWGQIVDHDLDFAPETELGSSEHSKVQCEEYCIQGDNCFPIMFPKNDPKLKTQGKCMPFFRAGFVCPTPPYQSLARDQINAVTSFLDASLVYGSEPSLASRL... | Heme-containing oxidoreductase which catalyzes the conversion of thiocyanate (SCN(-)) into antimicrobial agent hypothiocyanous acid (OSCN(-)) in the presence of hydrogen peroxide (H2O2) (By similarity). Also involved in the conversion of iodide (I(-)) into hypoiodite (IO(-)) in the presence of H2O2 (By similarity). Res... |
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