entry stringlengths 6 10 | entry_name stringlengths 5 11 | protein_name stringlengths 3 2.44k | sequence stringlengths 2 35.2k | function stringlengths 7 11k |
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G5EDB2 | MADD3_CAEEL | Probable dual specificity protein kinase madd-3 (EC 2.7.11.-) (Muscle arm development defective protein 3) | MPILHQKIASTGGQPSTNSLALRRLPLVVIPRKRKYKNYVSRRRNTQLLASLRRCVSDPNVYKSYNHWKALLRPMTPIKSGAPTPKTVTPMPVPQIPPHQKMTPNPTPTQNPVQLPLPHAVSEKPGDKKSTGPTPSPVPSKAPISAAKLPGTVTKVAPLLSAAQPPPKTLAPAPGASETNSGSGPVSKQVSGKLTELKSKNGTVTEKTEKAVLRIPSSASTRAKAASAVAPEANPAPVPTATKPSPFAPAIAPLRDGAPAQPPAPIQASAPLRPPVAKQNSLQKPPEPKRSVGAPPKALPSELVNKIDGIEFLPQSSNQN... | [Isoform a]: Probable dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Negatively regulates p38 MAPK signaling to allow for the plasma membrane of body wall muscle cells to form projections, also called muscle arms, that extend and connect the body wall muscles to target motor... |
G5EDB9 | RPGF_CAEEL | Rap guanine nucleotide exchange factor (RA-GEF) (PDZ-domain-containing exchange factor) | MDPRKPRQDPVNDARFYESLIKPPHLRTPDDIRNVYEQLRQLDTFSNLFIGPLKALCKTARYERHPAQYILFRDGDVARSWYILLSGSVFIENQIYMPYGCFGKRTGQNHRRTHNCLLLQESEMIVIDYPTEPQSNGMSPRTPPRGIHHSGEPVHQKTPRKSAPNMSVDSIAMPPPPVPPRPLRLPQTAAKGPAPLPPRGLPRTYPLDFPVDIPTTSSSSSNTSYNDQHRSQVYLNGLSADEDTLVRVKHRREKSNSVGGQAQNGISTARRLRGRSTASSTTTEGETASNEGADSDEDEGSMPSQESSSGGFMDLRDSVR... | Acts as a guanine nucleotide exchange factor for small G protein GTPases like rap-1 and rap-2. Required in the hypodermis, especially in the seam cells, for proper formation of the cuticle. |
G5EDE1 | GFI1H_CAEEL | Zinc finger protein GFI1 homolog pag-3 (Pattern of reporter gene expression abnormal protein 3) (Transcription factor pag-3) | MSTEHVSNVYSVESLLSNVEKSSVSPTESIEDRNEFMITEDVMSSWQRMAATISLQQKLLMMQQTMPRPPPVNILGNFPFGFLNAPMFWQQYLRSMAMGIIPQNPESPSASVWNRTPTPPVEIKPFHCQKCTKLFSTIAALEQHQQVHVSDKQFECKQCGKTFKRSSTLSTHLLIHSDTRPYPCEYCGKRFHQKSDMKKHTYIHTGEKPHKCTVCGKAFSQSSNLITHTRKHTGFKPFACDVCGRTFQRKVDRRRHRESHHPGHPEECVSASQISSDLSPKGYMTPPTSNGYLDSSDEFLNVFRLPAELLAIKAEMGEEM... | Transcription factor. Plays a role in the determination of neuroblast cell fate and neuronal differentiation. Negatively modulates expression of several components of dense-core vesicles (DCVs), thereby, in a DCV membrane protein ida-1-dependent manner, regulating neurosecretion. Negatively modulates the transcription ... |
G5EDE2 | CBXH2_CAEEL | Chromobox protein homolog hpl-2 (HP1-like heterochromatin protein 2) | MSSKSTKRAKIEDPKDNVFMVEKVLDKRTGKAGRDEFLIQWQGFPESDSSWEPRENLQCVEMLDEFEREFSKREKPIRKRHSQKPEPSEDQADPEEDKDEKKETNQNDKFSLEGKQLKCIVGLTKGPGELHFLCKFSDDTARLLPAKEVNSRYPSQVIRYYESKLTIQDPKADEL | Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Probably does not act as global transcriptional repressor, instead targeting a subset of genes. Involved in RNA processing mediated by Tar DNA-binding protein homolog tdp-1. Plays a role in linking epigenetic regulation with the innate... |
G5EDE5 | RGMB_CAEEL | Repulsive guidance molecule B homolog drag-1 (DRAGON homolog) | MSIVYLVSITFIFSVFKPITSCRVEECAAWFQKTKDYENLVPKATERYCQVLQTYLKCMNDTQRYCHGNLRFHSSELIMRRHWKEFECEKWESCNDNSHVKRKHVNTCYFNPPPSNRKLKYCSLFGDPHLIMFNGSVQTCSEEGARPLVDNRYFLVQVTNRNVRGEALTTTVTKVTVLVRKHNCTASLRYEASSDEEGLPRGFVDGTTFQMTSKHSVEVLWQDDNYVEIALHFIHSSIHIRRQGPYLSVSVRAPTIVLETGGDVARELCWSGCRKSSRIPAELAVEMTKKFAECYRRRVHVPKKVAEDRCKDIGNIGVFF... | Probably in association with the cell surface receptor unc-40, positively modulates the BMP-like Sma/Mab signaling pathway through interaction with both the ligand dbl-1 and its type I receptor sma-6. Regulates body size and this may be through modulation of the Sma/Mab signaling pathway. |
G5EDF7 | SEK1_CAEEL | Dual specificity mitogen-activated protein kinase kinase sek-1 (MAP kinase kinase sek-1) (EC 2.7.12.2) | MERKGRERKLPGMKIVMPTPVETPTMNLEDRCLIKLTNESEEIEIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRRSDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYKIGKHIPEPFIGKMALSVIEGLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPERIDGETKSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGFSVDCQYFVKRCLEKDYNERPKYPELLAMPFMEQARNEKQF... | Dual specificity protein kinase which acts as an essential component of the p38 signal transduction pathway which is also composed of upstream effector nsy-1 and downstream effector pmk-1. May phosphorylate pmk-1. Downstream of CaMKII unc-43 and adapter protein tir-1, plays a role in determining asymmetric cell fates i... |
G5EDJ0 | FAX1_CAEEL | Nuclear hormone receptor family member fax-1 | MSDEDEPLNFSTSKATEESKEGILGVRSIFNTPLLFPPPMFNAGVISPHIAAALAMSFNQQRMNASVSPPLDHTTISVNSFPSMGSVKTDSPPTASSPTLCCAVCGDVSSGKHYGILACNGCSGFFKRSVRRRLIYRCQAGTGNCVVDKAHRNQCQACRLKKCLNKGMNKDAVQNERQPRNTATIRPALDMDPQNFFREYAGAVSAIMGHSNMMKREDSPSSASDGKTEDEKKDSLQETTMSQLESVLQWAQQFRLFTVLTNSEKRQIILTQWPRLLCISLCEQAEDVSFDDHLTSLMLKFRRLDVSPAEFNCLKAITIF... | Orphan nuclear receptor that binds DNA containing an extended core motif half-site sequence 5'-ANGTCA-3'. Required for locomotion, neuron axon pathfinding, and regulation of expression of some peptide neurotransmitter precursors and of NMDA glutamate receptor genes. Involved in specifying interneuron identity, in conce... |
G5EDJ4 | SOC1_CAEEL | Multisubstrate adapter protein soc-1 (Suppressor Of Clr protein 1) | MSIPDENIILEGSLKRCKKYKLFKTKWVEHYFVLHCRDRERNLFAIDEFKTSRKNDLKKRFKLEFVIRVESNLSVSDPSILCTAGGGHQEESMLNCIFGVGFRFENIVKDLYLVAKNDEEMTLWVNEICKLCKLHRQHDEGDSSHAAESSISGMSMSSQSLDMSIIEQQQYAENIPESKQYHRMHHFKSVISHNSLPSNPNYNNLPDPLESSRSETSSMYSSRRTEDDSVSYTSGPPVPPPRTRHTLNRFVKNGQVGRLHMIPASTSMGQVVKVEDAEDSSGETLKLDTPEQYPESVTSSEGFPVYERNGKTLIRRAPPP... | Adapter protein which modulates signaling mediated by several receptor tyrosine kinases. Plays a role in fluid homeostasis, probably downstream of receptor egl-15 and upstream of let-60/Ras. Involved in nicotinic acetylcholine receptor (nAChR)-mediated sensitivity to nicotine and levamisole and gamma-aminobutyric acid ... |
G5EDK5 | CELR_CAEEL | Cadherin EGF LAG seven-pass G-type receptor fmi-1 (Protein flamingo homolog) | MMLDRIMFLLFFILSLVIGSFSEYLDDKYYSTNSIDVVCKPCAVPSSNSVIWLPASRPPCLHPGQPIIHWPDLSDNLACPVPGLPDSVHSSQISLLEGEGLLLTKERICFFDGPIDFHYDYVCDGKLYRSKMRIGHSIASKKKLETRRTKRWARRRNPDANAVHFQQEKYVKELPEDTPIETIIASVKASHASSQPLYYSMVAPQDSRSQNLFTLDTMSGEIRLAKSMDREVLDKHILKVTAYERVDPTISASTTVVVHVLDVQDNSPIFEKDSYFGEIREDAPIGTTVLSVFARDLDSGENGEIEYSLGEGNGKNLLAI... | During ventral cord development, required for axon fasciculation and navigation, mediating both pioneer and follower axon extension, guidance and track formation. Acts in CEPsh glia and SubL neurons to guide follower axons into the nerve ring. Promotes motorneuron development by positively regulating the extension of t... |
G5EDM4 | NHRF1_CAEEL | Na(+)/H(+) exchange regulatory cofactor-like protein nrfl-1 (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) | MVHIPSDVTPPRLCVVEKLNGENEYGYNLHAEKGRGQFVGTVDPDSPAERGGLITGDRIFAVNGHSIIGENHKKVVERIKANPNRCEMLVISEEGAKWYNENNVQITLDLPNIERVSPMSKETPVFVPPPPPPTDAMPYLPRLAELNKGTPDQEFGFNLHAERGRGHFIGTVDAGGIGEKAGLEAGQRIVGVNGQLIYPTTGHKEVVALIKKDTMKTTLLVASEDVDKYHKDHNIAYSWDNVERVDTRPVINVETHHHHEEVSVPKSNGYDVPPLNPHSIQVNEEREISKMTTTTRTETITNSNSAYQYKESSTAYDAYA... | Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression (By similarity). Anchors the amino acid transporter protein aat-6 to the apical cell membrane of intestinal cells, par... |
G5EDM7 | DAF5_CAEEL | Ski protein homolog (Abnormal dauer formation protein 5) | MSDSPIGSSQQVEPEHRTPDLMDIDPLIANLKALHEETRSDDDDDGQPSTSAKRKDSRADGIVIHQKKYSDPGRFLWIWLLGVRVPALSIDGEPHLPIEILDDMLTKKDKKDQMSFQNLLRYKNVYIRMASPSQFRAVMEKSKECENLNITSLSLMSRSDIERIMGELRLESMLTLAEHDNWDISDRVHVVHVNFIDYCSEWLESDDLEEDVMQSGTHGYWYKNRRNMRCIECQHCEGKFTPTDFIMHHHYPIKPSGFVHTGCNSFQWIRLIEVFDKSNENLEAWNKFVLNSHRAGKREYDEAAPHQAPPKRPAMETPVP... | Probable component of transcriptional regulatory complex with SMAD protein daf-3. Required to regulate entry into a developmentally arrested larval state known as dauer, in response to harsh environmental conditions. Involved in larvae undergoing cell-cycle arrest during the dauer stage. |
G5EDN3 | TIM_CAEEL | Protein timeless homolog | MNVLVQGAVHALGYYEDGKYSREPDCYESIRDLIRYLREDGDDHTARIECGRHNLVEQDLVPMVKCEDLTDDEFDIAIRLMVNLCQPAISTMRGKPPADRDQWKMYWELEENLRRAKTAFSDAHFFTAIKKRIDNYFIDTEYEDRDERLRLVVERIVLLIKYVFSINPDTSEGRRTRIEDSSHDRVIIAFLESGIDKTLMHIANQPREKEFHVTILDIFALILKEQTAEDLATKSEEVSTAEQKKTEEEFRKIIENHVVKETQKRKSFSRFGGSYTIKGLKGISANSSQVVFKPIQNVEKHNFLDDRKAKKRAPRNRRPF... | Plays an important role in chromosome cohesion during both mitosis and meiosis. In prophase of meiosis, it is involved in the formation of the synaptonemal complex (SC) and specifically, in the diplotene and diakinesis phases of prophase, it stabilizes the association of homologous chromosomes during synapsis and siste... |
G5EDN6 | CANB_CAEEL | Protein phosphatase 2B regulatory subunit cnb-1 (Calcineurin subunit B) | MGADASLPMEMCSNFDAYELRRLTRRFKKLDVDGSGSLSVEEFMSLPELQQNPLVQRVIDIFDEDGNGEVDFREFIQGISQFSVKGDKNTKLKFAFRIYDMDRDGFISNGELFQVLKMMVGNNLKDSQLQQIVDKTILFHDKDGDGKISFQEFCDVVEHTEVHKKMVLENI | Regulatory subunit of tax-6/calcineurin A, a calcium-dependent, calmodulin-stimulated protein phosphatase. Confers calcium sensitivity. Plays a role in egg-laying, fertility, growth, movement and cuticle development. Plays a role in sensitivity to CO2 levels. Regulates expression of tax-6 inhibitor rcn-1. Negatively re... |
G5EDP2 | NLTP2_CAEEL | Non-specific lipid-transfer protein-like 2 (NSL-TP2) (EC 2.3.1.176) (3-keto-acyl-CoA thiolase) (Abnormal dauer formation protein 22) (Propanoyl-CoA C-acyltransferase) (Protein P-44) | MTPTKPKVYIVGVGMTKFCKPGSVPGWDYPDMVKEAVTTALDDCKMKYSDIQQATVGYLFGGTCCGQRALYEVGLTGIPIFNVNNACASGSSGLFLGKQIIESGNSDVVLCAGFERMAPGSLENLAAPIDDRALSVDKHISVMSETYGLEPAPMTAQMFGNAAKEHMEKYGSKREHYAKIAYKNHLHSVHNPKSQFTKEFSLDQVINARKIYDFMGLLECSPTSDGAAAAVLVSEKFLEKNPRLKAQAVEIVGLKLGTDEPSVFAENSNIKMIGFDMIQKLAKQLWAETKLTPNDVQVIELHDCFAPNELITYEAIGLCP... | Catalyzes the thiolytic cleavage of 3-ketoacyl-CoA with 8-16 carbon residues in the acyl group using a ping-pong mechanism whereby binding to 3-ketooctanoyl-CoA results in the release of acetyl-CoA and the subsequent addition of CoA produces 3-ketohexanohyl-CoA. Involved in the biosynthesis of the dauer pheromone by pr... |
G5EDR3 | 2AB1_CAEEL | Serine/threonine-protein phosphatase 2A regulatory subunit sur-6 (Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit sur-6) (Serine/threonine-protein phosphatase 2A regulatory subunit B sur-6) (SUR-6/B55) (SUR-6/PR55) | MVMEVDEPAVAATTSQNQPQEHANDFDMDTSEGPIENDETFEPVDQINWKFNQVKGNIDADVHTEADVISCVEFSHDGEYLATGDKGGRVVIFQRDQSGKYVKGVRSREYNVYSTFQSHEPEFDYLKSLEIDEKINQIRWLKKKNAANFILSTNDKTIKLWKISERERKIGDDAWNLPRTNRINTSSFRGRLQIPSIVPMELIVEASPRRVYGNAHTYHVNSISVNSDQETFLSADDLRVNLWNLEITNESFNIVDIKPANMEELTEVITAAEFHPTQCNWFVYSSSKGSIRLCDMRDRALCDAYAKIFEEPEDPQSRSF... | Probable regulatory subunit of serine/threonine phosphatase let-92. Together with let-92 and constant regulatory subunit paa-1, positively regulates centriole duplication during early embryonic cell divisions by preventing the degradation of sas-5 and kinase zyg-1. In addition, during vulva development, may play a role... |
G5EDR5 | FUTA_CAEEL | Alpha-(1,3)-fucosyltransferase fut-1 (EC 2.4.1.214) (Fucosyltransferase fut-1) | MTARSIKLFFARWKYLMFACCITYLLVIYAPISKSEQKDWKEGEIELSNDHELDVPILQKEELKPQQRPSFEENVPKKKTFNFNPVGKEPFDVEEVLTSSDIKLEERMTATVIPGQKRLILSWNAGHSQDNLQGCPDWNCEFTQVRARAPDADAVLIAHMDNDFVPKPNQYVVYFSQESPANSGIQIPRPDYINMTLGFRHDTPAGSPYGYTVKLGAKSRKTGQVVDANLVNGKAKGAAWFVSHCQTNSKREDFVKKLQKHLQIDIYGGCGPMKCARGDSKCDTMLDTDYHFYVTFENSICEDYVTEKLWKSGYQNTIIP... | Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the first GlcNAc residue (with or without alpha 1,6-linked fucose), next to the peptide chains in N-glycans. Unlike in mammals, does not require the prior action of N-acetylglucosaminyltransferase I to generate complex N-glycans. |
G5EDS1 | VAB3_CAEEL | Paired box protein 6 homolog (Homeobox and paired domain-containing protein vab-3) (Protein male abnormal 18) (Variable abnormal morphology protein 3) | MSDAGHTGVNQLGGVFVNGRPLPDATRQRIVDLAHKGCRPCDISRLLQVSNGCVSKILCRYYESGTIRPRAIGGSKPRVATSDVVEKIEDYKRDQPSIFAWEIRDKLLADNICNNETIPSVSSINRVLRNLAAKKEQVTMQTELYDRIRIVDNFPYNSSWYGQWPIPMNGAVGLNPFVPAPLIEPKTEGEFEKDEDQKPPTEPEDDAAARMRLKRKLQRNRTSFTQVQIESLEKEFERTHYPDVFARERLAQKIQLPEARIQVWFSNRRAKWRREEKMRNKRSSGTMDSSLSNGTPTPTPGSVTGSNMTNPIGSPASTPN... | Transcription factor that binds a motif with the core sequence 5'-GCGTA-3' in the promoter of various genes. During development, required for cell fate specification probably by promoting or repressing expression of genes involved in specific cell fate. Involved in head epidermal morphogenesis. Involved in gonadal dist... |
G5EDT1 | LIN35_CAEEL | Retinoblastoma-like protein homolog lin-35 (Abnormal cell lineage protein 35) (Synthetic multivulva protein lin-35) | MPKRAADEPGTSTTDPFHEQSPFDAVLAGTETTDTICEEPPAKRIDLDIKQEFNGGVQSGGLIKNESELTQMTIKQETEGNINEARREEEDEEQDEDSRTSMPPALGEDDDYEEDDADSFIDKTNTPPPSQSFLEGCRAANLPNDIVTGAWETYNHAVQRVSLEGSESAWQLSAIYYYLLSKGIKRRGKTIRILIQPFPVSILTIANSFDISVAEMLDKTARFVEIIHSRKIRRYQEYIRRIQEGLAVSCVIFKKFCRIFCKIFEEIKVGSENCPSSHELFTVLWTSFLVMKSRMTVDDLISNYQLLFSILDQVYTEMCS... | Key regulator of cell division which acts as a transcriptional repressor and negatively regulates cell cycle progression in its active unphosphorylated form, but allows cell cycle progression when phosphorylated. When unphosphorylated and in its active form, interacts with E2F transcription factors such as efl-1 to rep... |
G5EDT6 | JKK1_CAEEL | Dual specificity mitogen-activated protein kinase kinase jkk-1 (MAP kinase kinase jkk-1) (EC 2.7.12.2) (JNK-1 activator kinase) (JNK kinase) | MENVCFQQRLRDLETRVRKWKFLKLGLTEVRLRPRDRRSTSVDQKHKECSSTSSSPQHQRPNNIGYLTSPMERKFTPLSMKPSPSRRDTEKDALEYEFLEGYKKSGTLEIDGEKQVVDPNEIHIISLLGSGSCGVVESATVRSKLMAVKTMYKNDNKENLKRILRDVRIMSMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFFPEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAHSKSAGCPPYMAPERLTIETNSKYDVRSDVWSLGITVYQLVTGL... | Dual specificity protein kinase which acts as an essential component of the JNK signal transduction pathway. May phosphorylate jnk-1. Plays a role in coordinating locomotion via D-type GABAergic motoneurons and in regulating synaptic vesicle transport downstream of adapter protein unc-16 and probably by activating jnk-... |
G5EDW2 | LPLT1_CAEEL | Latrophilin-like protein 1 | MRRNKTTYSLLQTILVACLLTVTPTFASNKPTTDESGTISHTICDGEAAELSCPAGKVISIVLGNYGRFSVAVCLPDNDIVPSNINCQNHKTKSILEKKCNGDSMCYFTVDKKTFTEDPCPNTPKYLEVKYNCVVPATTTTTTTTTSTTTTDSSLIVDEEEEAQKDALNSDVIKPVKKKEDVFCSATNRRGVNWQNTKSGTTSSAPCPEGSSGKQLWACTEEGQWLTEFPNSAGCESNWISSRNSVLSGVISSEDVSGLPEFLRNLGSETRRPMVGGDLPKVLHLLEKTVNVIAEESWAYQHLPLSNKGAVEVMNYMLRN... | Has a role in the establishment of anterior-posterior polarity in tissues during embryogenesis. Required for the alignment of the mitotic spindles and division planes. May have a role in cell death events. Required for normal defection and oocyte fertilization. Involved in sperm function. Operates in pharyngeal pumping... |
G5EDW5 | ADM2_CAEEL | Disintegrin and metalloproteinase domain-containing protein adm-2 (EC 3.4.24.-) | MTDTLDLKLSSRRQWNPVRCPVRLEVDGSAQTPTSLVQTALNNPSFDLVIAAPNGQNVYIPFTEDRKLFTANIADDPSTSSLISHCHFEGVTEDGRHALSLCDPGEITGLLMTQTNRFGLSTSNNGSFVLIPYVENNCDLGSLVHSSSRKKRQIGKQNTVIDRNPSYIREHLDGRKRFVELALVADYSVYTKYDSDEKKVNDYMQQTMNILNSLYFPLNIRITLVHSEIWKKGDQISVIPDSKETLNNFMEYKKIMLKDHFFDTGYLMTTLKFDEGVVGKAYKGTMCSYDYSGGIYVDHNNDTVETVATFAHELGHTFGM... | Metalloprotease that cleaves and releases a number of molecules (By similarity). Negative regulator of lrp-1 protein levels, potentially by influencing its endosomal trafficking. Involved in regulating the molting process. |
G5EDW7 | LIN8_CAEEL | Protein lin-8 (Abnormal cell lineage protein 8) | MSKIKTHSTGSKRTVPFYKLPPPVPLPPLPPPDPTRYFSTEKYIALSKDEKFKFDDYDVNDETLKKVVLNEIGKCPDIWSSRSQAAIMEHYPIVATETYRRTGLLLSIKSLKQIYKCGKDNLRNRLRVAIVSKRLTPAQVEAYMWRWEFYGFIRYYRDYTQRWEADLLKDLDVVLGLEARRASKNMEKVDSGELMEPMEPMDSTMDEMCVEEEPYEETGSNWSDPAPEPSQSKSQSPEAKYPQAYLLPEADEVYNPDDFYQEEHESASNAMYRIAFSQQYGGGGSPAVQKPVTFSAQPAPAPVREAPSPVVENVSSSSFT... | Acts as a synthetic multivulva class A (synMuvA) protein and redundantly inhibits lin-3/EGF expression to prevent inappropriate vulva induction. |
G5EDY0 | PIKI1_CAEEL | Phosphatidylinositol 3-kinase piki-1 (EC 2.7.1.137) (Phosphoinositide-3-kinase class 2) (PI3-kinase class 2) (PI3K class 2) | MSDDEELQLAIEISKKTFKDEQKLRSNDLDLIRFESPDEPARQRKINQIKQLYEANSPGPSSYSGSLATSPIDFRPVYNEPRAGPIPHSQSYPRNYFQDWSAIASTSQPPAFPPPPRPPKPEQYKFPPAPSVPLLHDRYFVPPPPPVPPRHSRVQQSPPVPIHPTPPVSSTPLRHSAPSFASDSQQFLSPIKPFEISFNSTVDTSSNQTGSHDHSIQYQPLTHLYVPYVMHSLNSSYGALLNGDLIDLSAFEDSSNASQDEIRKEFDPLFISTYSTDTPSPDNSMPAVNAYFSKPIDEPECVGGAKLIQENIEFPSSSFC... | Phosphatidylinositol 3-kinase involved in clearance of apoptotic cell corpses by phagosomes. Phagosome maturation requires two sequential and non-overlapping pulses of phosphatidylinositol-3-phosphate (PI3P) on the vesicle surface which mediates recruitment of sortins snx-1 and lst-4 and small GTPases rab-5, rab-2 and ... |
G5EDZ2 | UMPS_CAEEL | Uridine 5'-monophosphate synthase (UMP synthase) [Includes: Orotate phosphoribosyltransferase (OPRT) (OPRTase) (EC 2.4.2.10); Orotidine 5'-phosphate decarboxylase (ODC) (ODCase) (EC 4.1.1.23)] | MSSLTDKTRNGALKRNLLRQMLKASVFKFGEFQLKSGQISPIYIDLRECFGHPGLLMLISEAISKQVEISEVQYAGVLGIPYAALPYASVAAGNYLKKPLLIVRKEAKSYGTKKLIEGLYQPNDRLILIEDVVTTGGSILDVVKVLHTENLVASDVFCILDREQGGRQKLQDAGVTLHSLLDMQTVLTFLYSTGAIGDEQWHGIVQALNLPYTSPTKLEINSELENLSSLPYVENVRTPLAERESLTESALIKKILGIMRRKKSNLCLAVDYTTVEQCLQMIELAGPFVLAIKLHADAITDFNEEFTRKLTTMANDMDFI... | Bifunctional enzyme which catalyzes the formation of UMP from orotate in the de novo pathway of pyrimidine biosynthesis. May also form UMP from uracil. Regulates the size of gut granules during embryonic development. Involved in resistance to DNA damaging agents including UV-C and X-ray radiation. |
G5EE01 | PTEN_CAEEL | Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase daf-18 (EC 3.1.3.16) (EC 3.1.3.48) (EC 3.1.3.67) (Abnormal dauer formation protein 18) | MVTPPPDVPSTSTRSMARDLQENPNRQPGEPRVSEPYHNSIVERIRHIFRTAVSSNRCRTEYQNIDLDCAYITDRIIAIGYPATGIEANFRNSKVQTQQFLTRRHGKGNVKVFNLRGGYYYDADNFDGNVICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRTGVMICALLIYINFYPSPRQILDYYSIIRTKNNKGVTIPSQRRYIYYYHKLRERELNYLPLRMQLIGVYVERPPKTWGGGSKIKVEVGNGSTILFKPDPLIISKSNHQRERATWLNNCDTPNEFDTGEQKYHGFVSKRAYCFMVP... | Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins (By similarity). Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. By dephosphorylating PtdIns(3,4,5)P3... |
G5EE06 | FUTD_CAEEL | Alpha-(1,3)-fucosyltransferase fut-5 (EC 2.4.1.65) (Fucosyltransferase fut-5) | MKHNTLRAVFQFSFFIGICTFIMIAGYSYQINYNQRMGIFYGGNITFKKVPKVVIYTATPFFDVPIENSILRDCSEKIKNSCTVTSNNKTFPIADAIVFHSRDINETKLSFFNKNRRYDIPYIMMAMENPFFAGLTVYHNFFNWTMTYRTDSDIFHPYGAFVKSYVPAEVNYSEIWNSKTKETLWMVSNGNAQNKRKELVEKLIKKGMSIDLYGQLYKKEPAECPRRRGPPGCDVKFHSPYKFAIAFENSNCKDYVTEKFWKKAGIYKTVPIVMSRKIYRDLGIPDSMYIAVDDYPNLEEFVHHIQNVTSNEEEYMKYHK... | Catalyzes the addition of fucose in alpha 1-3 linkage to GalNAc-beta-1->4-GlcNAc-beta-1->3-Gal-beta-1->4-Glc (LDNT)acceptor. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-(Fuc-alp... |
G5EE07 | XBP1_CAEEL | X-box-binding protein 1 | MSNYPKRIYVLPARHVAAPQPQRMAPKRALPTEQVVAQLLGDDMGPSGPRKRERLNHLSQEEKMDRRKLKNRVAAQNARDKKKERSAKIEDVMRDLVEENRRLRAENERLRRQNKNLMNQQNESVMYMEENNENLMNSNDACIYQNVVYEEEVVGEVAPVVVVGGEDRRAFESAAFINEPQQWEQARSTSINNNISNQLRRMDSKKNNTISVDMYLTIISILCNHMDRNKKMDTSNKSSNISRAQAESSIDSLLATLRKEQTVMQRLVQADPCTHLQKRVKHFRRIP | Required for transcriptional regulation of the unfolded protein response (UPR) in the endoplasmic reticulum (ER) under stressed conditions, acting downstream of ire-1, and also maintaining ER homeostasis via a negative feedback loop, in parallel with ER kinase pek-1. May also regulate Golgi protein trafficking distal t... |
G5EE18 | CEH28_CAEEL | Homeobox protein ceh-28 (NK-2 homeodomain factor CEH-28) | MQSTQISSTTVILPSEVIQPPQQSAVPSEFKNTLPSRLNLFEGFDQSFSELTNPYQPVIPLMQRESLLGASSYYSSPSQNQRSYQNHRQHSNPDTINLRSQQQKRKPRVLFTQHQVNELEERFKKQRYVTATEREELAQCLGLTATQVKIWFQNRRYKCKRLAQDRTLQLSQIPFNPMFASAFPFGINSFGTAPSSSSSGS | Probable transcription factor that regulates neuronal differention, including synapse assembly of the cholinergic motor neuron M4. Activates expression of growth factor, neuropeptide and transcription factor genes, such as TGF-beta dbl-1, FMRFamide-like flp-5 and transcription repressor zag-1, in the M4 neuron. Require... |
G5EE56 | SRC1_CAEEL | Tyrosine protein-kinase src-1 (EC 2.7.10.2) (SRC oncogene related protein 1) | MGCLFSKERRSGGSDMGVSERIDVSRFQTPQQQTVFHVNNGGNEGTISQLNGTSDGMMGNGRGGGGGGGAQERETLVALYPYDSRADGDLSFQKGDAMYLLDHSNCDWWYVRHQRTGQTGYVPRNFVAKQQTIESEEWYAGKIPRNRAERLVLSSHLPKGTFLIREREADTREFALTIRDTDDQRNGGTVKHYKIKRLDHDQGYFITTRRTFRSLQELVRYYSDVPDGLCCQLTFPAPRLAPTRPDLSHDTQQNWEIPRNQLHLKRKLGDGNFGEVWYGKWRGIVEVAIKTMKPGTMSPEAFLQEAQIMKQCDHPNLVKL... | Non-receptor tyrosine-protein kinase which plays a role in endoderm development by controlling spindle orientation in EMS blastomere, probably downstream of receptor mes-1. Also involved in embryonic body morphogenesis, especially in the formation of the pharynx and the intestine. May be dispensable for pharyngeal musc... |
G5EE72 | MRP5_CAEEL | Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member mrp-5) | MPSDSEEVCLQQSGTGVYENVVYSKETSDRAKRYAGDTNRKTIGRYSAAVQNLIPLRTTERNKNNGGSRIDDAGLFSFVTYSWVFPYLYQAVRGKLDRNQVWGCSFYDSCGLNMARLEVLWEDEKKANAKSPSLFKVIYRFISTRLWFSCAVFFFCLIFGFIGPTCFIRRLIAFAENPERDEQSRIVYSYGIALVAAISVVEFARVLSYGATWAVSYRTGIRVRGAVLALLYKNVLNSKDLCGKTESDVINIFANDGQRLFDAVTFAPLVLVGPLVLVGGIGYLLMVIGRWSLLGILVFFVFDVIQFGLGKSMVACRNLA... | Heme transporter required for the export of intestinal heme to different tissues and subcellular compartments. Also, required for the export of vitamin B12 from the intestine of the mother to the embryo to support embryonic development. |
G5EE86 | TTX3_CAEEL | LIM/homeobox protein ttx-3 (Abnormal thermotaxis protein 3) | MYFQSLSADPLDSVNTTTDFNQLAQLLLMLTNSSSKETIATHVVTNSVPSAFQFDWSSHFKEEYDLVEKLNSPQYTNLTSISPSSSTDSNNLILRQIQIPKIEPALLNQCCLCTFAIVDKEISVVDGKYYHNNCLRCQMCDIPFEYSDKCYVRDGVFLCRADHAKRYQKCCRKCEIPLNREDMVMKAKEMIFHHACFVCFICGIKLNPGDYYTMSPQGHLYCHAHYNAVRSTVLCEEAAVATVPAVVAPPPPPPTTTTAPPPAAPEQPPREASTEAEASTDEDGNGSGSQRSKRMRTSFKHHQLRAMKTYFALNHNPDAK... | Transcription factor. Binds to a sequence motif, 5'-TTATTGGCTTCGTTAA-3', which may be involved in AIY interneuron function, in the regulatory elements of target genes binding is more efficient, in vitro, together with homeobox protein ceh-10. Required for specification of the AIA and AIY interneurons and the NSM neuron... |
G5EE96 | DIC_CAEEL | Mitochondrial dicarboxylate carrier (DIC) (Solute carrier family 25 member 10 homolog) | MAEDKTKRLGRWYFGGVAGAMAACCTHPLDLLKVQLQTQQQGKLTIGQLSLKIYKNDGILAFYNGVSASVLRQLTYSTTRFGIYETVKKQLPQDQPLPFYQKALLAGFAGACGGMVGTPGDLVNVRMQNDSKLPLEQRRNYKHALDGLVRITREEGFMKMFNGATMATSRAILMTIGQLSFYDQIKQTLISSGVAEDNLQTHFASSISAASVATVMTQPLDVMKTRMMNAAPGEFKGILDCFMFTAKLGPMGFFKGFIPAWARLAPHTVLTFIFFEQLRLKFGYAPPVKA | Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across mitochondrial inner membrane. Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulf... |
G5EEA1 | LIM4_CAEEL | LIM/homeobox protein lim-4 | MDAHLVQAKKTSTASELSDSSLTFPFIGDYLSSPSLTTSDYVSDCSNLTVEGPVPANQEFSSSDESSVYISSALRLADYAFTPDDNIRIKPDAVIVICTQCQHQIQDKFFLSIDGRNYHENCLQCSTCENPLSNKCFYKDKTFYCKGCYFRTHVTSTASSCRELGPKCASCDRTIQATDWVRRARNYVYHLACFSCNQCKRQLSTGEEYALQEGNLLCKQHFLELVEGDSGVSSQKAKTKRVRTTFAEDQLSVLQTYFNRDSNPDGADLEKIASMTGLSKRVTQVWFQNSRARQKKWHQKSEGDNGDSQRSSVGPSSPSQ... | Transcription factor that binds to the promoter of target genes. Regulates genes involved in serotonin synthesis and release in serotonergic ADF neurons. Involved in specification of neuron cell fate, olfactory receptor expression, locomotion, and foraging behavior. Required in AWB olfactory neurons to repress AWC cell... |
G5EEB1 | FPR18_CAEEL | FMRFamide peptide receptor frpr-18 (FLP2 receptor) | MESQQLMACAILVIVLVGIFGNSLSFILFSRPHMRSSSVNVLLCALSFFDFSLLTLSIPIFVIPNLDLWANDLSLSTYMAYILKLIYPINLMMQTCSVYIMVMITLERWVAVCRPLQVRVWCTPRKSRNAILVIIVSAFLYNFVRFFEYRFVVTESGALYEKWLRDPGKHRWYYVGYYTILYIVTHFLVPFSVMAFANGHVIVAMCKLSKTRQMLTRQQQREQSTTVMLLIVTFVFAICNTLPFLLNVSESIFPTLFQDESTRGLAYWLNDLSNLLVVLNSGTTFIIYFTFSEKYRQTLVFILKNGCCATVSDYNNYTAM... | G-protein coupled receptor for flp-2 neuropeptides. May act through the G(q) alpha type of G proteins. Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide ... |
G5EEC2 | FLP7_CAEEL | FMRFamide-like neuropeptides 7 [Cleaved into: TPMQRSSMVRF-amide 1; SPMQRSSMVRF-amide 1; SPMQRSSMVRF-amide 2; SPMQRSSMVRF-amide 3; SPMERSAMVRF-amide; SPMDRSKMVRF-amide; SSIDRASMVRL-amide; TPMQRSSMVRF-amide 2] | MLGSRFLLLALGLLVLVLAEESAEQQVQEPTELEKSGEQLSEEDLIDEQKRTPMQRSSMVRFGRSPMQRSSMVRFGKRSPMQRSSMVRFGKRSPMQRSSMVRFGKRSPMERSAMVRFGRSPMDRSKMVRFGRSSIDRASMVRLGKRTPMQRSSMVRFGKRSMEFEMQSNEKNIEDSE | FMRFamide-like neuropeptides. Stimulates serotonin-induced fat loss by binding to and activating the npr-22 receptor which leads to induction of the atgl-1 lipase and subsequent fat loss. Together with atfs-1, negatively regulates the expression of the transcription regulator hlh-11, to promote expression of atgl-1, an... |
G5EEC5 | HAM1_CAEEL | Stork-head box protein ham-1 (HSN abnormal migration 1) | MTYLAVVLNGPKAKNGRKVFDSFLEQNRQMFWNRELTSACESITYMGFMRPGTLFVSGPASQLTVLKDAWARRILKPAMGYTITSLGDLGAIQQVEQMHFVPLGDVICDAVAQLNRQGLAATEQAIRQYVARHCPHVAPPGIEMVRQTITSLLSTGFVYKMADHYFVSVPTNSPMRPPAKAATKTTKTTVECQTGASMMCPQQTSTSSDEHVIEPAKKDHKKCQNSNRRSIFARLFSRGMKPQTIMPSASPIHVGGPPTPPPAAMLPTKNKYPTYHHDLNEECQRKARRRNHPRRGETQKLLSSSSECLKYYPVDMPETR... | Probable transcription factor. Required for asymmetric cell division in neuroblasts, perhaps acting by regulating spindle positioning and myosin polarization, and thus the position of the cleavage plane. Required to produce daughter cell size asymmetry in neuroblasts undergoing asymmetric cell division, usually giving ... |
G5EED4 | NIPI3_CAEEL | Protein nipi-3 (No induction of peptide after drechmeria infection protein 3) (Tribbles homolog nipi-3) | MARTKCKTKTVANPRTGVRKTAKDLSEPVRQDAVSRRRPTTLPFVGNTSSRPRVFYDVLAKKNVVFPNVKAEYHYRVRNAPKIDPKNFGTTLPICYSSIGPAKTLELRPLGRLPPHIIKALNDHYVQLTRGSMVPAADLYNNGDHPAEQRIPTMLNENEYLRLIQELEEEEKSKQFSATSSSAPHVNPYSAQHLVNGEIIGIFVIYGTGLVTRAVCSQTREMFTAHVLPEWKASKVIDVIRRLQIPTDISSMTADEIRLSELCISKRMEIIKSNDRYILMNPCESATIHSYATERLDEITENDVMSIYQKVVEIVRFCHS... | Adapter protein that regulates different signaling pathways (By similarity). Required for larval development and viability. Involved in negatively modulating pmk-1 p38/MAPK signaling. Involved in innate immunity, acting either in a manner dependent upon, or independent of, the pmk-1 or pmk-3 p38/MAPK pathways. Has a pr... |
G5EEE1 | FUTE_CAEEL | Alpha-(1,3)-fucosyltransferase fut-6 (EC 2.4.1.-) | MSQIGGATCTWRYLGRFVTLGIYASVALFVWYTLVPTRSKHKDSIAINNNNADPATALIPVHTKNVVIYAATKFFGHPITTERFLATCPDVQNYCRITQEESEFDNADAVLFHNADYRGSTDKFKKMKSQRKPGVPYVLWSLESPTNDMFRPDSHMINWTMTYRTDSDVWAPYGTIVKLKNPVEVDLNAIWEGKTKTATWLASNCITQNHRFDLIKKIIDNGFEIDIWGNCGKQVSQCAGVDNQESPCVLELIKPYKFYISMENSNCKDYVTEKFWKALNDRMTIPIVLARKYYKDLGVPDSAYIAVDDYATLDEFLAHV... | Involved in the fucosylation of N-glycans. Preferentially catalyzes the addition of fucose in alpha 1-3 linkage to the distal GlcNAc residue in N-glycans. Catalyzes the transfer of fucose to Gal-beta-1-4-GlcNAc-alpha-pNP (LN-pNP) and Gal-beta-1-4-GlcNAc-beta-1-3-Gal-beta-1-4-Glc (LNnT). Unlike alpha-(1,3)-fucosyltransf... |
G5EEE9 | GCY23_CAEEL | Receptor-type guanylate cyclase gcy-23 (EC 4.6.1.2) | MRRELFIFLLLLGECANVKVKVGHIGAVGSMRNAEKILQLSKEQLTQEGVLGNDFDIEILNQMGCGESYEGVAVGADMYHVQGVRAFIGPYCNAELDAVAKMATFWNIPVVGYMASSNSFADKTIFKTLARVSLRTTNSLAEAAAALIKHYGWNKVAIATNTGAVAFERVQSFEEVFHQRGINVVRKIMLEEYTNAKAIMNSGLLQELENSARVVVCAFSSTRDMNKEFMQAVTLSGMNNANYAWILPWLQLETKDMAPWLGENGEYQQNVKDHFANSFIIDDVNGFDNTLVTPFKERLEASGYSTDDLEMKNIYGYIHL... | Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. |
G5EEG1 | NFYA1_CAEEL | Nuclear transcription factor Y subunit nfya-1 (CAAT box DNA-binding protein subunit nfya-1) | MNGASRGDVQRPTPVQAPAKRPIPPTVFRFEKASKIGTSLDTTPKELPIRRPVPLPGPRFVKDVNPSPPATSSPNVQTQCHQPPVVRSQTHQASVSQTTPTQTTPSQYTPASVSTARAPQFHRSSHVTPSQQQRIEQAFGPAPVSQSQPQNGSYIQYNEPSTSVASTTTSFYSPNESEPVFTHAISFKPNEPENGQKAREQLELLDSGKINEINQSKVPTTIELPPNCKLFQYSWVLDGIPRTLLVPMPMDATEEDVKAMLPKTLEMDSNLFNNARPRDELPVLSFPNGTVPNVEMIGPKVQQPMLVNPKQFNRIMRRRE... | Component of the sequence-specific heterotrimeric transcription factor (nfya-1-NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes to regulate their expression and control cellular identity in particular tissue types. In association with the components in the nfya-1-NF... |
G5EEG7 | SMU1_CAEEL | Smu-1 suppressor of mec-8 and unc-52 protein (Smu1) (Suppressor of Mec and Unc defects 1) | MSSIEIESSDVIRLIEQFLKESNLHRTLAILQEETNVSLNTVDSIDGFCNEITSGNWDNVLKTVQSLKLPAKKLIDLYEHVIIELVELRELATARLVARQTDPMILLKQIDPDRFARLESLINRPYFDGQEVYGDVSKEKRRSVIAQTLSSEVHVVAPSRLLSLLGQSLKWQLHQGLLPPGTAIDLFRGKAAQKEQIEERYPTMMARSIKFSTKSYPESAVFSPDANYLVSGSKDGFIEVWNYMNGKLRKDLKYQAQDNLMMMDAAVRCISFSRDSEMLATGSIDGKIKVWKVETGDCLRRFDRAHTKGVCAVRFSKDNS... | Involved in pre-mRNA splicing as a component of the spliceosome (By similarity). Selectively regulates alternative splicing of unc-52 exon 17. Thus, smu-1 mutants selectively suppress the effects of unc-52 nonsense mutations in exon 17 by promoting the accumulation of unc-52 isoforms that lack exon 17 and enhance the e... |
G5EEG9 | HLH2_CAEEL | Helix-loop-helix protein hlh-2 | MADPNSQLTSATTVATAAIAQPQVMLPNAYDYPYNIDPTTIQMPDYWSGYHLNPYPPMQTTDIDYSSAFLPTHPPTETPASVAAPTSATSDIKPIHATSSTSTTAPSTAPAPTSTTDVLELKPTTAPATNSAETSAIVAPQPLTNLTAPIDAMSSMYTWPQTYPGYLPPSEDNKASEAVNPYISIPPTYTFGADPSVADFSSYQQQLAGQPNGLGGDTNLVDYNHQFPPAGMSPHFDPNGYPGMTGMPPGSSASSVRNDKSASRATSRRRVQGPPSSGIPTRHSSSSRLSDNESMSDDKDTDRRSQNNARERVRVRDINS... | Transcription factor which binds the E box motif 5'-CA[TC][AG]TG-3'. Plays a key role in the anchor cell/ventral uterine precursor cell (AC/VU) decision required for VU fate. Regulates expression of lin-12/Notch receptor and putative ligand lag-2 in the presumptive AC and presumptive VU cells. Modulates expression of l... |
G5EEH5 | MXL1_CAEEL | Max-like protein 1 | MSDMSDLEDDQTGHCGSGEHSGPFDPKRHAREQHNALERRRRDNIKDMYTSLREVVPDANGERVQASRAVILKKAIESIEKGQSDSATLSVDVAEQESKNAKLREEIARLKAKKDPSSSQSIIQ | Transcriptional regulator which binds to the E box motif 5'-CACGTG-3', when in a heterodimeric complex with mdl-1. Involved in the control of lifespan in response to dietary restriction, the decline in protein homeostasis associated with normal aging and may overlap with the insulin-like signaling pathway. Involved in ... |
G5EEH9 | NUP98_CAEEL | Nuclear pore complex protein Nup98-Nup96 (EC 3.4.21.-) [Cleaved into: Nuclear pore complex protein Nup98 (98 kDa nucleoporin) (Nucleoporin Nup98) (CeNup98); Nuclear pore complex protein Nup96 (96 kDa nucleoporin) (Nucleoporin Nup96) (CeNup96)] | MFGQNKSFGSSSFGGGSSGSGLFGQNNQNNQNKGLFGQPANNSGTTGLFGAAQNKPAGSIFGAASNTSSIFGSPQQPQNNQSSLFGGGQNNANRSIFGSTSSAAPASSSLFGNNANNTGTSSIFGSNNNAPSGGGLFGASTVSGTTVKFEPPISSDTMMRNGTTQTISTKHMCISAMSKYDGKSIEELRVEDYIANRKAPGTGTTSTGGGLFGASNTTNQAGSSGLFGSSNAQQKTSLFGGASTSSPFGGNTSTANTGSSLFGNNNANTSAASGSLFGAKPAGSSLFGSTATTGASTFGQTTGSSLFGNQQPQTNTGGSL... | Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). Required for the nuclear import of hcp-4 during mitotic prophase, this step is essential for centrosome assembly and resolution. Regulates nucleoporin npp-5 localization to the nuclear membrane during interphase and to kine... |
G5EEI4 | ASP1_CAEEL | Aspartic protease 1 (EC 3.4.23.-) | MQTFVLLALVAACSAAVIQVPTHKTESLRAKLIKEGKYTAFLASQHAARAQQLNTGFQPFVDYFDDFYLGNITLGTPPQPATVVLDTGSSNLWVIDAACKTQACNGYPDSGYTKQKFDTTKSTTFVKETRKFSIQYGSGSCNGYLGKDVLNFGGLTVQSQEFGVSTHLADVFGYQPVDGILGLGWPALAVDQVVPPMQNLIAQKQLDAPLFTVWLDRNLQIAQGTPGGLITYGAIDTVNCAKQVTYVPLSAKTYWQFPLDAFAVGTYSETKKDQVISDTGTSWLGAPNTIVSAIVKQTKAVFDWSTELYTVDCSTMKTQP... | Aspartic protease, which is part of the necrosis cell death pathway. Promotes B.thuringiensis Cry6Aa stability by preventing its proteolysis by host gut proteases. Required for Cry6Aa-induced necrotic death of intestinal cells. Cry6Aa uptake into the host intestinal cells triggers an increase in intracellular Ca(2+) le... |
G5EEK3 | NOCA1_CAEEL | Non-centrosomal microtubule array protein 1 | MSNERVSTGSLGERLMLRTRSTRGSVRETLSKAIRSTLGRASSMERKDMPDRPKYGTALTAMTSTTPPSPKDRSSDSGDGDSPRPRKFSSKECARIYFSNTSSEHSSRSNSSTPRRVRHTTASSGYGSLSHLPPISYRKSSDPLNSLMSQSMYVQSPGMHIDEPKCTSLSQRRLYYEDSSETYIPSSPSLTTLKDFMMTNDDETFDDFDFDNDDVKSVISSASTSRIFSVDNRMSKYQKNQSLRQFLNSPVRLRKRGDTSRRDAVEAGFEPRDTVPRCHSTQSLRDVQRVRSYNNSQFQASDLSLNPNGSIRAACDSTSG... | Plays a role in the assembly of microtubule arrays in the germline acting redundantly with ptrn-1 to control circumferential microtubule assembly along the body which is necessary for larval development, viability, and morphology and integrity of the epidermis. Required for microtubule stability and anchorage by bindin... |
G5EEK9 | VPP2_CAEEL | V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa isoform a 2) (Rod-like larval lethality and dye-filling defective protein 1) | MGSLSRSEEMRFCQLIVEKDAAFNIVAEIGKQPYVQFKDLNPNVNSFQRTFVKDIRRYDEMERKLRFLESQIVKDEIVIPGRVDTGDYTILPTSELNTLEGTLTELEKDVKSMNDSDSQLKANFMDLKEWDAVLDKTDEFFQGGVDDQAQEELENLDEEGAVPRVEKGPVNYLVGIIRRERLNGFERVLWRACHHTAYIRSSDIEEELEDPGTGEKVHKSVFIIFLKGDRMRSIVEKVCDGFKAKLFKNCPKTFKERQSARNDVRARIQDLQTVLGQTREHRFRVLQAAANNHHQWLKQVRMIKTVFHMLNLFTFDGIGR... | Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in ... |
G5EEL0 | LIDB1_CAEEL | LIM domain-binding protein 1 | MYGHHPDYGYGNYGHPPPFAGPESSNSHYGMPPSQGTNSQNNMMMRSQATEPQPIGNTVSPLEFRIHDMNRRLYIFSSTGVSENDQQQWWDAFSHEFFDDDCKLWFVIGSEPVAFASRERYIINRQFIPKFFRSIFDSGMRELQYVLRGPSRECTLANGSQAYENENVLQITRYDQSSQFEVNTEGKLYVEFAPFDEVMNYRIKAWTLELKRSNEFVYNQNTADYRVEAQNPEQENKPRMGFFKSTFNLMTMLKILDPMQSIMSSAKSAPAITPREVMKRTLFQHHQVRQQNMRQQQLNQQMMIPAPEPEKPKPARKRQR... | Binds to the LIM domain of LIM domain-containing transcription factors. Required for the blmp-1-mediated transcriptional activation or repression of several hypodermal genes, such as bed-3. Regulates sam-10 nuclear localization in PLM neurons. Has a role in synaptic differentiation of PLM mechanosensory neurons. Involv... |
G5EEL5 | DBL1_CAEEL | Protein dbl-1 (Dpp and BMP-like protein 1) | MNDSVRTTTTISSTKSLVHSFQLSAILHLFLLISFTPMSAAADQHASHATRRGLLRKLGLEHVPVQTGPSIDVPQHMWDIYDDDNDVDWVRHYYPKEIIEDNEGFLLSYNLSLAARNAHNEEVTKATLKLRLRRNNKARRSGNISIYFFEDDINNDRFQIESRSVDNLTEWIDFDVTAAFLRRTNRISFFIDLPEDVEIEETQSSSLSSLPYARAQSAPLIVFSDLSEPSSVRRKRSAQTGNSERKNRKKGRKHHNTEAESNLCRRTDFYVDFDDLNWQDWIMAPKGYDAYQCQGSCPNPMPAQLNATNHAIIQSLLHSL... | Ligand for the serine/threonine-protein kinase receptor type-1 sma-6 which activates a TGF-beta-like signaling pathway. Multifunctional protein that is involved in body size, male ectodermal patterning, innate immunity, lipid metabolism and neural plasticity. Dose-dependent regulator of body size, probably influencing ... |
G5EEM0 | NH114_CAEEL | Nuclear hormone receptor 114 | MTPQSSPSSSRDHVCLVCQDFASGYHYGVPSCVGCKTFFRRTIMKKQKYICQFEGNCPVDKTIRCACRYCRFEKCLSVGMDRNALQQNRDPIGYTKRTRRPKKELKTTSDCSSDEGASTPPSVSPLQLSPPPISPLLFQAAPLKPRRCILQTLAEREKCANDLRLSEYLPIRSLHEALCSKALLNDTAFLEKWGQPSERHQIFDLRFVNHDDYHYWHERDWFLLTEYAKTFDVFEALDYQDKAELVRHAAITVPVLVQVWNSPDYGPDTIVFPDGAYFDRTPEPTRPAGLNRKKYQMLDLVLKPFRDLQLDATEFAAFKA... | Probable transcription factor which may have a role in detoxifying dietary metabolites arising from bacterial tryptophan metabolism. Required for fertility and involved in proper postembryonic germline development, especially germline stem cell (GSC) proliferation. Required for activation of the methionine/S-adenosylme... |
G5EEM5 | ZYG9_CAEEL | Zygote defective protein 9 | MSNWDYLDEVDILPKLPPNFDELRESKKWQERKEALEALLKVLTDNERLSTKASYAELIGHLQMVLAKDANINCQALAAKCIGKFATGLRAKFSSFAGPLLPVIFEKMKEKKPMLREPLVDCSNEVGRTMQSLETGQEDILAALAKPNPQIKQQTALFVARQLDLVVPAKQPKGFIKAVVPVFGKLTGDADQDVREASLQGLGAVQRIIGDKNVKNLLGDASSDEGKMKKIGEYAEKSTASFAEEQAKNAPPVAPTSSTPSASAASGDPSGGTATAVVSSGAPVAEADPWDFLDAFDVLSKMPDGFDTNIESKKWQERKE... | Plays a major role in organizing microtubules and spindle poles during mitosis and meiosis in one-cell stage embryos. Required for default nucleus positioning in oocytes. |
G5EEM6 | TAB1_CAEEL | TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1-like protein 1) (TAK1 kinase/MOM-4 binding Protein) | MGDDGFLDQYPANTDAGIGTVHSCRYSKQKNPVQNNDFLSCSMCIHNGPIKLYGIFSGFNGGDSTAKFVMNRLVYEIFGENPITPTLLPYQVVEEFKRKFENVAERYLLMNTDDLNNRLLKLEEQSETGNNAVSEINQKIRQGTTAIVVMIINQDLYVLNCGNSLAIAMNSENVVQLNSNLHNNDNPLEIVRIKGLGINPETVLNPTRAIGDLQRTHLFEETEAFKNAKGPPVISTPDVQYTKIDPSWRHLVLISDGVVQNLKEVEVENIPTEVSVRLIEDHTVTSTAQALVDSFARKHRDAYTMSDDKNFCISNHREEM... | Involved in the Wnt signaling pathway by regulating mom-4 kinase activity. |
G5EEM9 | PLA1_CAEEL | Intracellular phospholipase A1 (IPLA-1) (PLA(1)) (EC 3.1.1.111) (EC 3.1.1.4) | MSGSEEEHLVSLTFRKNEEDMDEDEGKVKQKEKPKEKQMEFVNQNFVESTEDESEVSTPTAVGLPIGTSTPDGDETPTQPDPNGKYTMAQTKDADLSRPSGLPSNGNPGSSTTVPPASKSGPVAPPRPSGTPVAPQRNRRRKVTELKCSEVRWFFQEPKGTLWNPFNGRDSIMLEIKYRKEKGIELDEAMQEIYDESLTHYKMEMKDEPEIENGNIGMEQEKPMVVVMNGQYKVNKDNSKIDPIYWKDDSKEIRRGSWFSPDYQPLEMPLSDQIEKNHLQCFRNQMIPEGTTVFSKSETSNKPVLAELHVDGYDIRWSSV... | Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids, being phosphatidylinositol (PI) its major substrate. PI is a versatile lipid that not only serves as a structural component of cellular membranes, but also plays important roles in signal transduction through d... |
G5EEN4 | GCK3_CAEEL | Germinal center kinase 3 (EC 2.7.11.1) (STE20-like serine/threonine kinase) | MSSSNLAGNTNTTTTSSAASAAAAHSAANASTITSEYSTTQTTTGTFNTDTLSSIGSTSTLHGSQPSQPPPPPPPQVSSPIAAAAAASAALVAQLNPADRWPTEPSAYKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYDFKADIWSLGILAIELATGTA... | Plays a role in osmotic stress responses by regulating ion homeostasis and by controlling cell volume via the phosphorylation-mediated inhibition of the chloride channel clh-3. In addition, increases gpdh-1 translation upon osmotic stress, likely downstream of wnk-1. Involved in several developmental processes includin... |
G5EEQ5 | REF1_CAEEL | Regulator of fusion ref-1 | MVLISTPPPAYAHNRKTSQEKKRRDEINAKIKELQLLIQNESDNEKMTQGDVLNRAVEVVSRMETESPGPSSNPNRKGFFDGFRSIESLTYSFIKSLGVNSDVCQDFVQRAKQFFDRERSSLLSTVSGKSKRRSESEILHSSMSYRSQSSSPSTSESGITIDRKEVKKNREQDRRDRQGEAFDALKNFIIENKLMTSHQVEKMQRLNTLDIIIAYIQNKKHNFVSRSDQEQSLYAHAIAEGKKTAKNIAFQFFKSDRHLVVRCADLEKFFEFSLSPKPLFGFPSMPIPIPPPSFPIFPFRPFPFFPMPMAPMATSPKSQQ... | Probable transcription factor. Binds 5'-TGCCACGTGTCCA-3' in vitro, probably via the E-box motif 5'-CA[TC][AG]TG-3'. Acts in embryonic development in a Notch-dependent manner, perhaps as a direct target of transcriptional regulator lag-1 in the Notch signaling pathway. Also acts in embryonic development in a Notch-indep... |
G5EET5 | CBXH1_CAEEL | Chromobox protein homolog hpl-1 (HP1-like heterochromatin protein 1) | MSRQNPVRSTRGNSLRAREAQQAQDAPLFQESSSNVFVVEKVLNKRLTRGGSEYYIKWQGFPESECSWEPIENLQCDRMIQEYEKEAAKRTTRKRRYSPQPSTSSSAELQPSTSDEWAGKTLKTIIGITKAPGELHFLCKFSDDSVHLIPLREANVRFPSQVIKFYETRLVLQGVSPTIPGGMS | Seems to be involved in transcriptional silencing in heterochromatin-like complexes (By similarity). Involved in epigenetic repression (By similarity). Probably does not act as global transcriptional repressor. Plays a role in linking epigenetic regulation with the innate immune response. Acting in concert with chromob... |
G5EET6 | EFA6_CAEEL | Exchange factor for Arf-6 (Arf guanine nucleotide exchange factor efa-6) (Pleckstrin homology domain-containing protein efa-6) | MAKVASSGAEEALATIDGAPRRNVKKSEAFVMSGDVLISLNRNVSSTYAKLLGDQLPPGTTVASSIHPHQLSRATASAGVSFPSMNRNGAAAQKLSRLPVPVSTSQIERRGSLARKTSEESSPTAIRMLKTAPIERMESTDVEESEEETVMMTTDEKENQKKPNENDDEVMVVDEEQFIVVSNDMKSPNEEIVAKSLRSAMFTMPTDNHHHSYNSSPQISTLSPHLRSNGDGPSRSPVYDDVDDDLNGSLDAKDMSNNSHQQSFRSPENYSEKDTPSKHSVVTIDGSGVSNHYDQDGMFSHVYYSTQDTTPKHGSPSLRK... | Guanine nucleotide exchange factor for arf-6 (By similarity). Involved in response to injury in mechanosensory neurons. Inhibits axon regrowth via microtubule dynamics, possibly by inducing axonal microtubule catastrophes. Limits microtubule growth near the cellular cortex of early embryonic cells. |
G5EEU3 | AEX1_CAEEL | C2 domain-containing protein aex-1 | MREEALESICAALSISFTEDPDHLESIIDRFSEIFKVKDHLNQLRKKCEKFQTFTLEIRPVGSSNCTENVYAYIIESETCRQLELKPTGTTKLEIGSDKNVSLKFGLSQKKDSTTSKKGLSRSASLLKKLKFSDKKNLDELKISIFPLDIAVRKNINLGSGKSTLLEMKLIRNDHRNMIQCLEFDDFLEMTRSFHEWQAQISESELYDGSLGDPTFSMFYSIAFFFEIPSFVLKLTEMTCFLVWDDEMKKLDERALADVSLKMTACESEVDLQHPLLSPALSYLNDCTCNTIRCILVPFSTEPFFPPVSPSRLKSINVAL... | Involved in retrograde signaling from post-synaptic cells to pre-synaptic neurons, probably by regulating vesicle exocytosis in post-synaptic cells. Acts in muscles, to regulate the localization of synaptic vesicle fusion protein unc-13 likely during vesicle exocytosis and thus regulate retrograde signaling at the neur... |
G5EEV2 | TRR1_CAEEL | Transcription-associated protein 1 (Cel-trr-1) (TRRAP-like protein 1) | MDPAMASPGYRSVQSDRSNHLTELETRIQNLADNSQRDDVKLKMLQEIWSTIENHFTLSSHEKVVERLILSFLQVFCNTSPQFIAENNTQQLRKLMLEIILRLSNVEAMKHHSKEIIKQMMRLITVENEENANLAIKIVTDQGRSTGKMQYCGEVSQIMVSFKTMVIDLTASGRAGDMFNIKEHKAPPSTSSDEQVITEYLKTCYYQQTVLLNGTEGKPPLKYNMIPSAHQSTKVLLEVPYLVIFFYQHFKTAIQTEALDFMRLGLDFLNVRVPDEDKLKTNQIITDDFVSAQSRFLSFVNIMAKIPAFMDLIMQNGPLL... | Influences germ cell fate in hermaphrodites. Acts downstream of tra-2 and tra-3 and through the Tip60 histone acetyltransferase complex to regulate germ cell fate decisions (By similarity). Required for spermatogenesis and embryonic development (By similarity). Acts with tra-2 to promote expression of fog-3 and control... |
G5EEV9 | SID2_CAEEL | Systemic RNA interference defective protein 2 | MPRFVYFCFALIALLPISWTMDGILITDVEIHVDVCQISCKASNTASLLINDAPFTPMCNSAGDQIFFTYNGTAAISDLKNVTFILEVTTDTKNCTFTANYTGYFTPDPKSKPFQLGFASATLNRDMGKVTKTIMEDSGEMVEQDFSNSSAVPTPASTTPLPQSTVAHLTIAYVHLQYEETKTVVNKNGGAVAVAVIEGIALIAILAFLGYRTMVNHKLQNSTRTNGLYGYDNNNSSRITVPDAMRMSDIPPPRDPMYASPPTPLSQPTPARNTVMTTQELVVPTANSSAAQPSTTSNGQFNDPFATLESW | Plays a role in RNA-mediated gene silencing by mediating endocytic uptake of double-stranded RNA (dsRNA) ingested from the environment into intestinal cells from the intestinal lumen. Selective for dsRNAs of at least 50 bp. Required for avoidance behavior induced by small RNAs derived from pathogenic bacteria such as P... |
G5EEW6 | SIG7_CAEEL | Peptidyl-prolyl cis-trans isomerase sig-7 (EC 5.2.1.8) (Cyclophilin-like protein sig-7) (Silencer in germline 7) | MAVLIETTLGDLIIDLFVKERPRCSLNFLKLCKKKYYNLNQFHSIERNYVAQTGDPTGTGKGGESVYSDMYGEQGRYFEREDLPKMRHTRMGIVSFVNNGDNMLGSQFFITLGENLDYLDDQHTIFGQVTEGLETLEKLNEQLADTNNRPFKDIRISHTIVLDDPFDEDARISFPPRSPSPTYEMLVKTDQIALDEKEDEDEGKTAEEIAEELQQREMAEQAQILEMVGDLKDADEVPPENVLFVCKLNPVTTDEDLEIIFSRFGKINNCEIVRDRRSGDSLQYAFIEFDNAKSCEQAFFKMDNVLIDDRRIHVDFSQSV... | Probable PPIase that accelerates the folding of proteins (By similarity). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Involved in RNA polymerase II (RNA pol II)-mediated transcription elongation, and in primary transcript splicing, including co-transcriptio... |
G5EF15 | POS1_CAEEL | RNA-binding protein pos-1 (Posterior segregation protein pos-1) (Zinc-finger protein pos-1) | MADNDFLSGEAIMVFKKEILDSHSDFTRSLSHQSASPEAYDQENVFSQDFQPFMKQDKETQNSASQPTSEQSLANRDPCTVPDDLREEMMRQRRKEDAFKTALCDAYKRSQACSYGDQCRFAHGVHELRLPMNPRGRNHPKYKTVLCDKFSMTGNCKYGTRCQFIHKIVDGNAAKLASGAHANTSSKSPARNAAAHNHSLFVPQGSTDRSMDLNQSLPIRQSDLVRAFARATRLDVSGYNSTAQLAQYFESQFQRIQQLSSHHH | RNA-binding protein that coordinates cell fate specification and differentiation during early embryogenesis. Binds to a consensus pos-1 recognition element (PRE) consisting of the sequence 5'-UA(U 2-3)RGD(N 1-3)G-3', where R is any purine, D is A, G, or U, and N is any base. The PRE motif is found within the 3' untrans... |
G5EF33 | MIG13_CAEEL | Abnormal cell migration protein 13 | MTKLLIALILFSICWKPYSAEPIASFFDGLDSRNECKARLDRRLTGFSGLLYSHSKYGQEPYNTSRNCVLMLVAPIGYSIRVRALQFDVASTENARTCEKDTLHVFDHETTLDPESYAPARIDDITSPGPIIGQFCGHFENRILNTSSHNALTLWWHSNPNGSNSKGFKLHWGSFRVSKTGNCVTGEFSCGNGECIPIESACDRFADCSNGEDLIHSRQMAANCQNIELDPLTTVSGVFVLLFSATIILSLCGFIMFVCCLCKCLKSTIPIKGASSHTTTTTATDYKPDPPQFYPPSPPKMPPPSAASSYTPRLHHHFEG... | Probable receptor that acts as an upstream signaling protein to promote the guidance, migration and positioning of the right Q neuroblast (QR) and its descendants along the anteroposterior body axis, and also the anterior migration of BDU interneurons during larval development. Associates with and recruits the downstre... |
G5EF48 | FLD1_CAEEL | TLC domain-containing protein fld-1 (Membrane fluidity homeostasis protein 1) | MRQLAELLTDLLGPVPTMFLWVIVSFAFFRALQFIVRWYLFGKWTWPNFNFFDIRNRIRRRRRGGQEAENTENPPENEAEAGEQVEQEPEPDSRDLSAIPPNKKWRISNECVSLFHSVISGLWAAYALLYYKQLVQDLVNYRCDVAINLVLMSAGYLFHDLVDLLVNEQSARIIELLFHHVVVLSAFAVTMFFNRFLGVVVFGLLMELNSIFLHSRSLLNLYGVDKKSPSFRIIALLNMVTLFAFRLCVSAYLVYFVVVSIPDLEWYVSIINGLVIASLASTNTVLTYRLLAADGLLGSRRTRRTPAATAETQVGDVESG... | Regulates the composition and fluidity of the plasma membrane. Inhibits the incorporation of membrane-fluidizing phospholipids containing omega-3 long-chain polyunsaturated fatty acids (LCPUFA) and thereby promotes membrane rigidity. Does not appear to have any effect on LCPUFA synthesis. |
G5EF53 | SWSN4_CAEEL | SWI/SNF chromatin remodeling complex core catalytic subunit swsn-4 (EC 3.6.4.-) (ATP-dependent helicase swsn-4) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) (CeSMARCA4) (SMARCA4) (SWI2/SNF2-like protein) | MSGRPAFEQFTAQPPQPAGEVVAQQAGDGAQGQELTISKLENAITSMEEQGLQNDHRHAKAVLLKQKLQSGLPDAVPGQENGGNQQITPAQLNQLRAQVSAYRLLARNEQVPANLIADAVMLRPKVTTLLPEPYEYPGEAENGEKLPYDLMKIFNLHQIRCNRPTTISVPSGIDPVGMLKQRENMIQNRIGLRMKLLNNLPADIPDHMKLKAEIELRALRLVNLQTQVRSEVMACLKRDTTLETALNPYAYRRTKRQSLREARVTEKLEKQQKMEQERKRRQKHTDLMQAIIQHGKEFKEYHRNNLLKMAKSRKAVMTYH... | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) (By similarity). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucle... |
G5EF60 | STIM1_CAEEL | Stromal interaction molecule 1 | MGRVSWIIALYLTINVVIVVNGDRVTRNVEVTAEEEKIRDKLGYEAIRDIHRDMDDDHSGSIDRNESTGFMKEDMQMRGSERTRRENKFHGDDDAITVDDLWEAWFESIERTWTNERLVEWLINDVNLPSIVEAVKAKKIDGKILPRFASPNSDFLNKELGIKSSVYRQKLRLNSLDVVLFGYKDNNNRTKDILLAFLALLLTSLIFLYVRQKQKAQQKVNELSNKLTELKCMETEFEDVQKMLNDERSKRSISDGVVNHTEMENLRVQLEEAERRLEANSNGSQAPLALQPLLRRTCENEMAFLEKQRQDCFKEMKEAI... | Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor which upon Ca(2+) depletion, activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, orai-1. Essential for Ca (2+) and IP3-dependent contractile activity ... |
G5EF76 | LIN22_CAEEL | Helix-loop-helix protein lin-22 (Lineage abnormal protein 22) | MTSFLCSDTEIESDGGISRCKKIKNKPLMEKKRRARINKSLSQLKQILIQDEHKNSIQHSKWEKADILEMAVEYLQQLRSAQPCSLSPSTSSISTPPTPKEEIRNIKVPLNPIASFLNPMMQQYVAYQQLAQLSMYTQLFNNPAGVPLRADAGVTAQSPELAEKLKIEDRSRV | Probable transcription factor. During development, required for cell fate specification, probably by promoting or repressing expression of genes involved in specific cell fate. Involved in specifying lineages derived from the epidermal stem cells of the lateral ectoderm, known as seam cells. Modulates symmetric divisio... |
G5EF96 | UNC40_CAEEL | Netrin receptor unc-40 (Uncoordinated protein 40) | MILRHFGFILIILTVYLSSTHATTRKHHRRSIDNDARNLGFQFVMEPRRNVTVMESSSHLLECSYVLAHERLVHDVRIEWKRDGVLLSERTSSRIKVMSNGSLWIESVSSAEEGTYQCAVHVTTKSDQTSDTWTFLSRKATLRLADLAKFELQAIDRTLAKGQPTAFHCLINSKPTPTAVWLHNDEPIVNGGEYHILPVSNTLEISSTQSRHEGTYRCTVEGAGKRRSSQTARLTVTTETVSNELVFITTPRLQVVEQGDEFLLECLVASLIRPQVRWLKDSRQIIVDGVRIRRVGVSSILVSRASIEDTGLYTCRASNN... | Receptor for netrin unc-6 required for asymmetric axon formation, axon guidance and cell migrations. Required during axon formation, in response to unc-6, to initiate, maintain and orient asymmetric neuronal growth, and may signal via phosphoinositide 3-kinase (PI3K). Mediates axon attraction of neuronal growth cones i... |
G5EFA2 | BIR1_CAEEL | Chromosomal passenger complex protein bir-1 (Baculoviral IAP repeat-containing protein bir-1) | MAPGTKKKSDMAKFTFYKDRLMTFKNFEYDRDPDAKCTSQAVAQAGFYCTGPQSGKCAFCNKELDFDPEDDPWYEHTKRDEPCEFVRIGKLDDSELTINDTVRLSQTAMIMTKLFEHEMMINNLSNHSSSDALFDQLKKVPNTASTTKSNSRRGK | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of chromosome segregation and cytokinesis. The CPC complex has essential functions at the centromere in ensuring correct chromosome condensation, alignment and segregation. In the complex, required to direct the Aurora B/air-2 ... |
G5EFC3 | KCNAG_CAEEL | Potassium voltage-gated channel protein egl-36 (Egg-laying defective protein 36) | MLDACSFNRFDSNRSSARRFSRRGSDYFGDKGISMDERIVLNVGGVRHETYQATLKKIPATRLSRLTPSLANFDPLLNEYFFDRHPAVFAMILNYYRTGKLHYPTDVCGPLFEEELQYWGLDASDTEPCCWMQLLHAKDTQETLAVLDRMDADHEDDPQLREQDTMKKFGWEEDYFQGKRTRWMKLKPQMWSLFDEPYSSQAAKLIAGISVLFIFISIFSFCLKTHQSFRLPVLIGQNITMPGGVVQPSIERVSTEPLPIFGQIEMLCNIWFTLELIIRFVFCPSKIRFFKSPLNMIDLVATLSFYADAMMVRVVEDEPK... | Voltage-dependent potassium channel involved in the excitation of muscles operating egg-laying and defecation. |
G5EFD2 | KSRA_CAEEL | Kinase suppressor of Ras A (EC 2.7.11.1) | MMQTQVASRAGYSNLPQFGAGIAQDIKTQAINNLKECLKLTTINRFLTSSYEEDAKSVERKIFSAVYQMTKIGLIDREKREINAIWFTFVGLSAQNIRHLEICSITDFNALFSITNQELRSLADRGRLDVETKRKLLQSTVILQNHWNAYHSRTSSGSTDEPSGQSTPAIVTPSPKFNVPSLSVTSAKMIQSSSMGFATTPKSPKTSSRLVHAIPHKWHRSTKFRFSGDAVCHFCQRPLGFGFLNAWEKCRSCKWKVHTQCKGRVGDSCGLTPDHLRFLFDKLIQENNGGMWKDPQSVPGSRSMNEPAFQFPDTAIDSSS... | Serine/threonine-protein kinase which positively regulates Ras-mediated signaling probably acting at the level of let-60/ras or/and lin-45/raf. Involved in sex myoblast migration. Plays a role in responses to M.nematophilum-mediated bacterial infection by promoting tail swelling and preventing constipation. Functions r... |
G5EFD4 | HMT1_CAEEL | Heavy metal tolerance factor 1 | MGFSPFLDECRAEGLWPIGPSCNKIISFGVYTFFIVVNFIVLCIPNSNSANNNYRRMTDDDASSTSKLTISKILSICTIFAVICQSIFYFCFTFYFHPYTHLLLAFCVSKLFFWILSLCSFSKWRNQPSTPISLAFAFSAALLIHCIPLTDWKKYFEPTSKNRGDLTFYIIELALVTVVFFFTIVTGLFNFSGCSSRESAWNNLSKKVVTVAPYIWPTKSISLQLRVVFCLFLLIIGRLINVSLPILSKWIVDELATPDTFQYSLLFLATFLKFLQGNGAMGGFLNTVRTYLWIPIQQYTTRELEVELFKHLHSLSLRWH... | May play a pivotal role in the detoxification of heavy metals such as cadmium but do not depend exclusively on phytochelatins (PC) synthesis. |
G5EFD5 | UNC71_CAEEL | Disintegrin and metalloproteinase domain-containing protein unc-71 (Uncoordinated protein 71) | MICASKITMLGLLVMCTLGGVLGKVDIRQTTANKAFMETMRADGYEVVHPFQIRDKNERIGIDTRNYFLKAQEHYSHVTIVIRSNQLGRLKLVLERNNFIFLNQTAFHKLDADGERVIQNRVENCYYQGTVGGEESSFVALSSCNGLRGVISFANGTTFGIWPLDGGDRNSRRHPHILYKSEWSQEAKCGSSMAHAVGQRRMKKHVHKHRSHHHEHNKKRDVSKRTKYVEVALIADYEFMKARGLHDLDAISYMLESLNIADSMLSRDLNIRLSAVYVELWTDVQRIDLWEDIERTLSGVVDYASGHIYHIQKDASILFT... | Involved in the migration of sex myoblasts (progenitors of egg-laying muscles), Q neuroblasts and BDU interneurons during development. Involved in axon branching and guidance of neurons including GABAergic type D motor neurons. Promotes sex myoblast migration and positioning independently of gonad attraction cues. May ... |
G5EFD9 | ADA10_CAEEL | Disintegrin and metalloproteinase domain-containing protein 10 homolog (ADAM 10 homolog) (EC 3.4.24.81) | MSSPIRNRLQLVVTLIFCLFFENVNGLNNFIDNFETLNYRATHVANQVTRRKRSIDSAASHYQEPIGFRFNAYNRTFHVQLHPIDDSLFHEDHMSDVDGGYADIKPSHFLYEGYLKDDPNSHVHGSVFDGVFEGHIQTGEGRRYSIDKAAKYFERDDRPTQYHSIIYRDDEINHRKWRVKRDAENLSEQMQGCGFSSRVRREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRTCSLYMQADHKLYEHIRMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEGTNFNGIKGLHFVIQRTSIYTPDSCDRGRA... | Metalloprotease (By similarity). Acts together with protease adm-4 and in a cell autonomous manner to facilitate lin-12/Notch signaling during developmental cell fate decision, including anchor cell/ventral uterine precursor cell decision and vulva precursor cell specification. By modulating glp-1/Notch signaling, play... |
G5EFE7 | FUT8_CAEEL | Alpha-(1,6)-fucosyltransferase (Alpha1-6FucT) (EC 2.4.1.68) (Fucosyltransferase 8) (GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,6-fucosyltransferase) (GDP-fucose--glycoprotein fucosyltransferase) (Glycoprotein 6-alpha-L-fucosyltransferase) | MLKCIAAVGTVVWMTMFLFLYSQLSNNQSGGDSIRAWRQTKEAIDKLQEQNEDLKSILEKERQERNDQHKKIMEQSHQLPPNPENPSLPKPEPVKEIISKPSILGPVQQEVQKRMLDDRIREMFYLLHSQTIENSTKILLETQMISLMGLSAQLEKLEGSEEERFKQRTAITQRIFKSIEKLQNPKACSEAKTLVCNLDKECGFGCQLHHVTYCAITAFATQRMMVLKRDGSSWKYSSHGWTSVFKKLSKCSFDEAVGNTEAKPFAEPSPARVVSLGIVDSLITKPTFLPQAVPEQLLESLTSLHSHPPAFFVGTFISYL... | Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans. The addition is prevented if the GlcNAc residue is already fucosylated. Involved in susceptibility to the nematotoxic C.cinerea galectin Cgl2, likely by contributing to the synthesis of core alpha... |
G5EFF1 | ASD2_CAEEL | RNA-binding protein asd-2 (Alternative splicing defective protein 2) | MDCDNGVVSEISDDKELLNLETVIPPPPNDSGHEFIGPSSGPPQVTITPSGVQSGSANGVSTSQQQQYSAEYLSQLLKDKKQLAAFPNVFHHLERLADEEINKVRVVLFQCEFSKESAPLPDAEGDSTVHTEKVFVPAKEHPDYNFVGRILGPRGMTAKQLEQETGCKIMVRGRGSMRDKKKEELNRGKPNWEHLSEELHVLIQCEDTENRAKVKLMRAVEEVRKLLVPAPEGEDDLKRKQLMELAIINGTYRSGTDQSALAAAQLAAVKHQQQPFAAALQAAALQRGVLPMMANGLSRSPTMAVCGAPIVMSPSGRASS... | RNA-binding protein that binds to the 5'-NACUAAY-N(1,20)-UAAY-3' consensus sequence in pre-mRNA introns to promote alternative splicing. Required for mutually exclusive alternative splicing where it modulates the switch between mutually exclusive exons during pre-mRNA maturation. Involved in muscle-specific gene expres... |
G5EFF4 | SEM4_CAEEL | Spalt-like protein sem-4 (Sex muscle abnormal protein sem-4) (Transcription factor sem-4) | MNELLAEMAAVSSRRKQSKPRRMSGEGDAMMSPIDLSTKSFDENNCEKGAGGALPLEDRSNILPHFSVPFANPQQFLSLCAQLGNSSSRNVSSTASTTSSCPIQSCSQSFSSPAALTWHVLDAHEDEQEIFSCDVCTTTFSNGQDIREHKCQKTLASRSTSVPPSTIPSSVCFLSTPTTPCLQFSINESIGTSEIREEDEEEDMDVEDGEHVANQLFGHLLQKSDDKSKMASLFNHAFPPFAAFPNMPPPFLMRQPFDPRADVFAAGRHDNDDDWEALMEISTSDEAEKIRALVGDKAVPTTDPNQCILCRRVLSCKSAL... | Transcription factor, involved in positive and negative modulation of transcription. Binds to multiple DNA sequence motifs in the regulatory elements of target genes, including homeobox selector egl-5 and LIM homeobox mec-3. Involved in cell-fate regulation in multiple lineages, including neuronal, mesodermal and vulva... |
G5EFF5 | DAF12_CAEEL | Nuclear hormone receptor family member daf-12 (Abnormal dauer formation protein 12) | MGTNGGVIAEQSMEIETNENPDKVEEPVVRRKRVTRRRHRRIHSKNNCLTPPNSDDDPQMSTPDDPVIHSPPSIGAAPGMNGYHGSGVKLEESSGACGSPDDGLLDSSEESRRRQKTCRVCGDHATGYNFNVITCESCKAFFRRNALRPKEFKCPYSEDCEINSVSRRFCQKCRLRKCFTVGMKKEWILNEEQLRRRKNSRLNNTGTCNKRSQPGNQQSPQGPNQQPHLSPHHPGVAIYPPQPQRPLTINPMDNQMMHHMQANRPNAMPQLISPPGAQPYPLTSPVGSSASDSPPNRSLTMMHNGEKSPDGYDPNIMAHR... | Nuclear receptor which binds directly to response elements in target gene promoters. Activity is modulated by binding of steroid hormone ligands that include dafachronic acids. Regulates expression of genes involved in postembryonic development and the dauer diapause, in response to environmental cues. Inhibits the exp... |
G5EFF7 | UBQL_CAEEL | Ubiquilin | MATESALIKVHVKSPSNKYDVEIAADASVSELKDKVLVFVPTANKEQVCIIYTGKILKDEETLTQHKIADGHTVHLVIRNQARPTPAPAAATPTASSAPSSNPTPSSQPNPTNNPFAAMGGMGSPADILNNPDAMRSVMDNPITQQLLGNPEFMRTIIQSNPQFQALIERNPEVGHILNDPNVMRQTMEMIRNPNMFQEMMRNHDQAIRNLQGIPGGEAALERLYNDVQEPLLNSATNSLSGNPFASLRGDQSSEPRVDRAGQENNEALPNPWASNANQATNNQSNNRSADFNSLLDSPGISSLMEQMMSNPSMQASMFS... | May play a role in the ER-associated protein degradation pathway (ERAD) possibly via its interaction with ER-localized proteins ubxn-4 and cdc-48.1 and/or cdc48.2, providing a link between the polyubiquitinated ERAD substrates and the proteasome. Also plays an important role in the regulation of other protein degradati... |
G5EFH8 | CBS1_CAEEL | Cystathionine beta-synthase cbs-1 (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase) | MIQNEVSATHGSTKKGITYNTILEAAQRPTPLVPLKKLKVEHQLQSDIYVKLEYLNIAGSLEDRTADKAFQFAEEIGVVRGDEVFVTAGGSAAISYATVAAVKGIKLTIYAPKGEFDLVDTVLHTLGVKTVELPFGTFAEARVQTDEAAQQKGVFSLNKFTTNAAFVANLQKTALEIEKAVNNKSIGKVGAVVIPLNTGAAAAGIAAYYKGIGEHGVRVVGVTCKKDTIPEMGLDLKNDLLQEYNVEKREVEEDEAYSFTRHLIGTEGIMAGPSSGAAVLEAIKLAKELPAGSTIVVVLMDGIRNYLRHFLDDDWITANK... | Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. Plays a role in maintaining homocysteine homeostasis. Involved in cold-induced somatic longevity... |
G5EFI7 | MYRF1_CAEEL | Myelin regulatory factor homolog 1 (EC 3.4.-.-) (Polyglutamine-repeat protein 47) [Cleaved into: Myelin regulatory factor homolog 1, N-terminal; Myelin regulatory factor homolog 1, C-terminal] | MSSSDLLKGEFDGLNSEHFNMMQYLTQDTDEDDGSMVSPTSSADSMHQNLGVQQQQQQMLQAQQRQNQNGIFQPRRFPESPAMTDPCGNVSSSSSSSHHSDPMFSPNEFNGYAGANDNGNQTMNNIQSQQLSQQQHQQTRGGNLMMPQQSSIHAQMQNMNAPQFWSQPGTAAVNQPTNTLAQLNLFNIIRGGADSGMPSPVLEMPRKRSRLDTPCETPRIAPSFAGIDGFPDENYSQQQAIRFSKFQEEQWSPLYDINAQPLQQLQVHVVADKGFNYNSNDNCFVNQKKNHFQISVNVEASDTMPPKYVNFNNRLVPIRD... | [Myelin regulatory factor homolog 1]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor homolog 1, N-terminal component that specifically activates transcription of genes involved in synaptic rewiring during nervous system maturation. [M... |
G5EFI8 | PLCE1_CAEEL | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Phosphoinositide phospholipase C-epsilon plc-1) (Phosphoinositide-specific phospholipase PLC210) (Phospholipase C-epsilon plc-1) (PLC-epsilon plc-1) | MNWDTLKGVLKTRRLTKRTIPAYIHPTSRSDSTSSTQSATAGFILNEEPITLFRLELERLQYILHFPEEVAFQLSSTEYQLFYSIQPMDYVRYVSCDLTSVPVSENPSPVRNLVKRLSEVSSWITHVIVSQPTHDDRKVALTAILRIVETCWNIGNFNAAVEVLMGLKSEKLRPFWLSLRQEEKSQFDSLCETLLPANQALPSQAYINAVQRALRMPQSRVIPFFGIFLRDLYAIVNDLPNIVVIGQEGETQKLEFMSDPNGEDHFSSRIGVGGLLNADKINLVAIVLDNLELFHRHSRTMIKLLEEQAVPPIQIPQNER... | The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. plc-1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (R... |
G5EFJ4 | CAPG1_CAEEL | Condensin complex subunit capg-1 | MPPKKRIRGPKLPALREEKSTGTDVASDESFNESADFLNNEELNNDQNDAENTVLSEGVSTLRINENMTKEDRACISAALFIKKRVVESIRTVFQSRDDINDEIHTSSRKLIAAFKKADQNRKKKVDLMKVFLDEIDVRLSMIIEEVTVPEHRARVFKLIAVTITEIQAFKLPSDLLDFIINFINTWGHSDNVAARINTTCFISYIFETGKRYLTTEGEYSGFEVKIAAKMFLQLKRALLDKEQTARVPAIRGLGFLQEIPIPSNWPVDAMKHSPRELLLRSCRDTAWECRLVAVQSMVPLETDVRLLSDIVYYDKCLNV... | Member of two distinct condensin I complexes, the condensin I complex and the condensin I-like dosage compensation complex. The condensin I complex is required for conversion of interphase chromatin into mitotic-like condensed chromosomes and for chromosome segregation in meiosis and mitosis. As a member of the condens... |
G5EFJ9 | UN103_CAEEL | Potassium voltage-gated channel unc-103 (Ether-a-go-go-related gene potassium channel homolog) (ERG homolog) (Eag-related protein homolog) (Ether-a-go-go-related protein homolog) (Uncoordinated protein 103) | MKTAVFGRDSGEPGSPCGAPPSLTFTPPATLVPPTHHHSRSTNRGGVSGTGGGGSGGLQGAPGAGGPRASHSSRRTSRLHNNVSALGVLSLGADVLPEYKLQPTRIHHCTIVHYSPFKAVWDWIILLLVIYTAVFTPYVAAFLLRELQDTAKKSRFTEPLEIVDLIVDIMFIVDIIINFRTTYVNENDEACQVVSDPGKIATHYFKGWFIIDMVAAVPFDLLLVSTNSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLLLLMATFALIAHWLACIWYAIGSAELSHKEYTWLHQLSKQLAQPYTSTNGTIPTGG... | Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly (By similarity). Regulates the movements of the male's copulatory spicules before and during male mating behavior. |
G5EFL0 | GLD4_CAEEL | Poly(A) RNA polymerase gld-4 (EC 2.7.7.19) (Defective in germ line development protein 4) (Germline development defective-4) | MNEDSRLSSSQQPSTSTPRSSIPSTMNSDEPNTCRRLSQSQEQPSTSRTCKSETPEFGYSDSLPFAPWRRKRYGLNIQGLHEEIVDMYHWIKPNEIESRLRTKVFEKVRDSVLRRWKQKTIKISMFGSLRTNLFLPTSDIDVLVECDDWVGTPGDWLAETARGLEADNIAESVMVYGGAFVPIVKMVDRDTRLSIDISFNTVQGVRAASYIAKVKEEFPLIEPLVLLLKQFLHYRNLNQTFTGGLSSYGLVLLLVNFFQLYALNMRSRTIYDRGVNLGHLLLRFLELYSLEFNFEEMGISPGQCCYIPKSASGARYGHKQ... | Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. The enzymatic activity is enhanced by its interaction with gls-1. Required, together with gld-2, for early meiotic progression in male and female germ cells and for gld-1 protein accumulation in ... |
G5EFM9 | NEKL3_CAEEL | Serine/threonine-protein kinase nekl-3 (EC 2.7.11.34) (Molting protein MLT-1) (Never in mitosis A kinase-like 3) (NimA kinase-like 3) | MDKISNIYNFDDPPPDKLSLELFIIEKKIGKGQFSEVFRAQCTWVDLHVALKKIQVFEMVDQKARQDCLKEIDLLKQLNHVNVIRYYASFIDNNQLNIVLELAEAGDMSRMIKHFKKGGRLIPEKTIWKYFVQLARALAHMHSKRIMHRDIKPANVFITGNGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIQESGYNFKSDLWSTGCLLYEMAALQSPFYGDKMNLYSLCKKIENCEYPPLPADIYSTQLRDLVSRCILPEASKRPETSEVLQVAEHMNNYFSPSGDQSTTPSTQF | Probable serine/threonine-protein kinase required for the completion of molting. |
G5EFN6 | FLP2_CAEEL | FMRFamide-like neuropeptides 2 [Cleaved into: SPREPIRF-amide; LRGEPIRF-amide] | MQVSGILSALFLVLLAVIVSPFQFVQPKRILPIPTSRDQLLRGQLAYLKGTTVAQPAVNDNTLGIFEASAMAKRLRGEPIRFGKRSPREPIRFGKRFNPLPDYDFQ | FMRFamide-like neuropeptides. Involved in mediating arousal from the sleep-like state called lethargus, which occurs during molting between larval and adult stages, in part by regulating touch sensitivity, and working in concert with neuropeptide pdf-1. Involved in neural modulation of systemic mitochondrial unfolded p... |
G5EFP5 | FUTC_CAEEL | Alpha-(1,3)-fucosyltransferase fut-3 (EC 2.4.1.65) (Fucosyltransferase fut-3) | MRVRPASVYRYLLLGVCALLGIYTVYSIIGYDDGSHVPIHRPQRHLYLTVSQDRIGSRFGKLAPKRILYWTTIFGATVPSTALSDCPGLTDRCVIDTNRHQLDSADAVVFHAADISKFPLPVSRKPDQIFVFNSMETPDNSGRFAVPDGFFNWTSTHLYSSDAIHKYGTFLIPTQIAESRGFKVQSYYVQPKRLVKTMKGIFGLISNCHTKSKRELALQELGKHINVTIGGKCASDDRLKSICPAGVECIDVFEQYPFYIAIENTVCNDYVTEKIWSRITVPSIPIVMRRRVYQNILPPKSFIAMDDYKNPSEMANHLRS... | Catalyzes the addition of fucose in alpha 1-3 linkage. Unlike fut-1, does not add fucose to Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-GlcNAc-beta-1-Asn (M3), Man-alpha-1->3-(Man-alpha-1->6)-Man-beta-1->4-GlcNAc-beta-1->4-(Fuc-alpha-1->6)-GlcNAc-beta-1-Asn (M3F6) or GlcNAc-beta-1->2-Man-alpha-1->3-(... |
G5EFQ0 | GCY18_CAEEL | Receptor-type guanylate cyclase gcy-18 (EC 4.6.1.2) | MLKTLLFILIFFNIPIIAIEEIPDIKENGEKSSYTQFDNGAKLEVNKEHKRVIKIGHIGAVGVMPNDARILNISKENLIEEGLVGDDIEFEIVSRQACSESFEGVAVAAELYHVHQVRAFIGPYCAAELEAVTKMATFWNIPIISYSSVPNAVSDRSVYKTLARVSSKNTNSIAEATVALLLHYKWLKVAIATNTGSTAFERVSIFEEIMHREGVTIVKKVMFDENTDANEMMNSGQLGDLAANARIIICLFSSTKELSKEFMQATYTMRMNNAEYAYIIPWLQSGTKDLTPWIGADGEMLQRVKDHYANAIIVDDVNGF... | Guanylate cyclase involved in the production of the second messenger cGMP (By similarity). Regulates thermotaxis responses in AFD sensory neurons. May regulate AFD neuronal activity such as calcium responses to temperature gradients. |
G5EFQ5 | RUNX1_CAEEL | Runt-related transcription factor rnt-1 | MTNVFHHVRNFIEQQPAPAKTLEKSSSPNILYTALPKHWRSNKSFQEPFYVVLLTPVPDNTEVSIWAGNDEKPCEEVRNEKAKVHRQVAKFNDLRFVGRSGRGRKFHLTIVIHSAPMMVATVKNVIKVTVDGPRDARIPKPQGSLKRQAEQQTIFPNDIIRTPGPPMPMTMIPPPWFPLPMTQTFPPSFFPLISPGPHPSISAALWKIHSESMKTPIKQKVEQENVSLNTSTCLSSPSIFITPTSDDRKLKRPSSPRSITKSSETSINLIQETPESVESKRRRNVSITSSNSSSPTIWRPF | Transcription factor (By similarity). Binds to regulatory DNA sequences in order to modulate transcription negatively autoregulates its own expression, perhaps dependent upon CBF beta homolog bro-1. Promotes proliferation, and prevents differentiation, of seam cells, a stem cell-like lineage, acting in concert with bro... |
G5EFR6 | MCA1_CAEEL | Plasma membrane calcium-transporting ATPase mca-1 (EC 7.2.2.10) (Membrane calcium ATPase-1) | MQKSQNVTAVTETNGVAAALGGHHTSPDTNAGKTKDAKEFGCSLGDLRGLMEARGAEAIVRLSTEHEGVEGLCKKLKTDSLVGLNGEQADLDRRRHVYGANTIPPAKSKGFVRLVLDACKDPTLVILVLSGFINLALSFYEPTSAAEDATQHLVNATTAAILANGTFMSTTEAPSEGHGTAWIEGVAILLCVIVVVLVTAVNDYSKERQFRSLQEKIETGQKFSVIRNGEAIDVPVSDLVVGDIARVKYGDLLPADGFLIQSNDLKIDESSLTGESDHIKKSIESDPVLLSGTYAMEGSGKMLITAVGVNSQTGIIMTLL... | Catalyzes the hydrolysis of ATP coupled with the transport of calcium across a membrane. |
G5EFS2 | MSI1H_CAEEL | RNA-binding protein Musashi homolog 1 (Musashi-1) | MTTTVSTGATAVATLRETSPPVDGHEEARLNADSDDGSHGSQDPGKMFIGGLSWQTTAENLRDYFGRFGEVNECMVMRDPATKRARGFGFITFVDPSSVDKVLNNREHELDGKKIDPKVAFPKRTQAKLVTKTKKVFIGGLSATSTLEDMKQYFETYGKVEDAMLMFDKATQRHRGFGFVTFDSDEVADKVCEIHFHEINGKMVECKKAQPKEVMLPVQLNKSRAAAARNLYGMPPETLLAYAQYLPRFGGNLMYPNFTNVFNNMPGGYSGLSTPGGSSNRPPHQFDTASLYSLNNGGQLLDSQAQMFMNQQSYHSHSKY | RNA binding protein that regulates the expression of target mRNAs at the translation level. Binds RNA containing the 5'-[GA]U(1-3)AGU-3' motif located in the 3' UTR of the target mRNA (By similarity). Binds to the mRNA of three Arp2/3 complex components arx-1, arx-2 and arx-3 and negatively regulates their translation ... |
G5EFS4 | DCPS_CAEEL | m7GpppX diphosphatase (EC 3.6.1.59) (Decapping scavenger enzyme) (Heat shock-like protein) (Protein DCS-1) (Scavenger mRNA-decapping enzyme DcpS) | MKRIADEELVREERAEESTQKWLQDAKFQEILGADSSHKSLFVLLSHPDGSQGILLANKSPFSEEKSDIEKLLATAQLQEISRNDIFGSYNIEIDPKLNLLKSQLIYPINDRLIAKYRQEEKFVIRETPELYETVTRPYIEKYQLNLNWVYNCLEKRSEVDKIVFEDPDNENGFVLLQDIKWDGKTLENLYVLAICHRHGLKSVRDLTGDDLEMLYNMRDKSLEAINQKYGLKTDQIKCYFHYQPSFYHLHVHFINLKYDAPASTTMSAILLDDVINNLELNPEHYKKSTLTFTRKNGDKLMEMFREALKN | Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs of the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) and tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)Gp... |
G5EFT4 | AMP1_CAEEL | Aminopeptidase ltah-1.1 (EC 3.4.11.6) (Aminopeptidase-1) (AP-1) (Arginine aminopeptidase 1) (Leukotriene A4 hydrolase homolog ltah-1.1) | MAPPHPRDPSTAANYEQVTVSHYALKWKVDFEKKHIAGDVSITLDVKQDTERIVLDTRDLSVQSVALNLNGEPKKAGFTLEDNQALGQKLVITTESLKSGDRPVLEIKYESSNNAAALQFLTAEQTTDRVAPYLFSQCQAINARSIVPCMDTPSVKSTYEAEVCVPIGLTCLMSAIGQGSTPSECGKRTIFSFKQPVSIPSYLLAIVVGHLERKEISERCAVWAEPSQAEASFYEFAETEKILKVAEDVAGPYVWGRYDLVVLPATFPFGGMENPCLTFITPTLLAGDRSLVNVIAHEISHSWTGNLVTNFSWEHFWLNE... | Aminopeptidase which preferentially removes N-terminal Arg and Lys residues from peptides and proteins. |
G5EFT5 | HSF1_CAEEL | Heat shock transcription factor hsf-1 | MQPTGNQIQQNQQQQQQLIMRVPKQEVSVSGAARRYVQQAPPNRPPRQNHQNGAIGGKKSSVTIQEVPNNAYLETLNKSGNNKVDDDKLPVFLIKLWNIVEDPNLQSIVHWDDSGASFHISDPYLFGRNVLPHFFKHNNMNSMVRQLNMYGFRKMTPLSQGGLTRTESDQDHLEFSHPCFVQGRPELLSQIKRKQSARTVEDKQVNEQTQQNLEVVMAEMRAMREKAKNMEDKMNKLTKENRDMWTQMGSMRQQHARQQQYFKKLLHFLVSVMQPGLSKRVAKRGVLEIDFCAANGTAGPNSKRARMNSEEGPYKDVCDL... | Functions as a stress-inducible and DNA-binding transcription factor, playing a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage. Upon exposure t... |
G5EFU0 | PK2_CAEEL | Serine/threonine-protein kinase pak-2 (EC 2.7.11.1) (p21-activated kinase 2) | MNRTFSLRRKVKKSEISTPSNFEHRIHAGFDARSGTYTGLPKQWQALLGPPRSISRPKPMVDPSCITPVDVAELKTVIRGPSSSFRYNSPLPFGMTNSPMPSVARSNSLRISATASPVVNVSSARHSFRPTLPPVSQRGYPFNDPSYAPLPLRNQKPPMSTTFGVEKPHQYQQIITIVAPSRTTTPQLQPKSPSTPQAMRQQPKCTEGVSDEEFRNALKFVVDGTDPRSDLTDYKQIGEGSTGVVEAAYKISTKQIVAVKRMNLRKQQRRELLFNEVSILRQYQHPNIVRFFSSHLVDDELWVVMEFMEGGSLTDIVTAT... | Serine/threonine-protein kinase which plays a redundant role with pak-1 in embryogenesis but, in contrast to pak-1, is not involved in commissural axon guidance of ventral cord motoneurons or in distal tip cell (DTC) migration. |
G5EFV3 | RSA2_CAEEL | Regulator of spindle assembly protein 2 | MSKIPVFKGSFKSWLAKNDEKPAKSVLLEPKYRDHHEKISFRNKENMEEGEKPVFVSMANPQPTREDYERYDEDRRLKDKARDLRIARRRNSATPEASPSSDQYFTPEPADDEFVTPSTSKKSQKPRSSDATPVSSKPPRYLPRTPLSEQYTSCLSRKMEENFSRMQELMISGHSPHEARQQTIQESSEQLEPRAKVTRSSSQPPPIDTLKPRVPRIESPLVKKTTETPIRRTSYVDTLVATHQIQLQYSDRVVVGVERQMTKLESIKNLAAANRSPIIAEEAKKRRNEAEAVRKLIEVETQNAKKRAVIQELKDRIDKL... | Recruits rsa-1 and, thereby, phosphatase let-92/paa-1 complex to the centrosomes. Recruits sys-1/beta-catenin to mitotic centrosomes during the first embryonic cell divisions. |
G5EFV5 | CDK7_CAEEL | Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 7) | MSRRYDTIKHLGEGQFANVYLAQDLESGECVAIKKIKLGSREEAKDGINRTAIREIKLLKEIHHDNIIGLRDVIGHRTSIQLVFDFMDTDLEHVIKDKEIILMPAHIKNITMQMLLGLEFLHVHWILHRDLKPNNLLMNKMGRVKLTDFGLARFFGSPNRNYTHQVVTRWYRAPELLFGARSYGVGIDIWSVGCIIAELLLRNPIFPGESDIDQLVKIFNILGCPTPETWPNMTEMNSYVIIKPQTEYMALNYYFSAAPQDLLDLMAGMWTFDPIKRLTCTQSLQMEYFRTQPFCCLDEELPLPKKQQPQKRSRRLDDDG... | Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Required for maintaining chromosome ploidy. May phosphorylate the large subunit of RNA polymerase II, ama-1. |
G5EFV8 | VPS52_CAEEL | Vacuolar protein sorting-associated protein 52 homolog | MPRTRVNLQKSEANDRSFTISSLEFCLSQLRKADPNLVKKAIASGDGLTESKNDVSTRLSEAHRYSVQQCLDNSEQLAQLHNQLVHCDNVFERLQATLYSFQDNLGSIGQDMKNLQLQSHHIHQELENRQKVRVELSQFVDDIAVSQTMMKTINDTDANDRGFLEALHELHHKITLILQRGNGDAVAVNDTMPILEGLKLKAVVKVREWLLQKMFQFRKPLSNYQVFQHQLLKCRFFYEFLLHHDLISAKELQDEYIDTISKMFFTYFKAYATRLFKLAMKDVATKEDALGSIDFAKPAGLGAIFSSKQHVVRNKATVFS... | Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex facilitates tethering as well as SNARE complex assembly at the Golgi. Plays a role in the trafficking of cargo to dense-core vesicles, probably through associat... |
G5EFW7 | IF122_CAEEL | Intraflagellar transport protein 122 homolog (Abnormal dauer formation protein 10) | MRPNLLWVDKILDENNEAGVCIYDLAFKPDGSELLLAADNKVYLFDVNEGGQMQTLKGHKDLVYTVAWSHNGELFASGGADKLVILWNEKHEGTLRYSHTDVIQCMMFNPCNQILLTCALNEFGLWSTADKNVIKQRSVVRCCSCAWNTDGTIFAIGHGDGTITLRKGTNATEEPSIIIQRDNEPIWGIAFSSNRTFASRDSQGNPMGIDEIMAVIDWNKTLSFYSLDGTFIESKNLEFEPHCISYCLNGEYLLIGGSDKILKIYTRKGVLLGTVAQMDHWIWSVTVRPNSQTVAMGCVDGTIACYNLVFSTVHCVDHAR... | Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Plays a role in chemotaxis and sensory perception. Required for entry into and exit from the dauer larval stage and this may be mediated by daf-12, daf-16 and daf-41. ... |
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