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[
{
"type": "text",
"content": "A Phase I Study of Pelabresib (CPI-0610), a Small-Molecule Inhibitor of BET Proteins, in Patients with Relapsed or Refractory Lymphoma"
}
] | Purpose: NF-κB, a transcription factor essential for inflammatory responses, is constitutively activated in many lymphomas. In preclinical studies, pelabresib (CPI-0610), an investigational (BET) bromodomain inhibitor, downregulated NF-κB signaling and demonstrated antitumor activity in vitro . Here we report the safet... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "Introduction",
"paragraphs": [
{
"aggregated_text": "Bromodomain and extraterminal domain (BET) proteins include a family of four related proteins (BRD2, BRD3, BRD4, and BRDT), each containing two tandem amino-terminal bromodomains (... | Cancer Research Communications | PMC10010313 | 10.1158/2767-9764.CRC-22-0060 | CRC-22-0060 | [
[
"Blum",
"Kristie A.",
"aff1"
],
[
"Supko",
"Jeffrey G.",
"aff2"
],
[
"Maris",
"Michael B.",
"aff3"
],
[
"Flinn",
"Ian W.",
"aff4"
],
[
"Goy",
"Andre",
"aff5"
],
[
"Younes",
"Anas",
"aff6"
],
[
"Bobba",
"Suresh"... | [
[
"aff1",
"Emory University School of Medicine, Atlanta, Georgia."
],
[
"aff2",
"Massachusetts General Hospital, Boston, Massachusetts."
],
[
"aff3",
"Colorado Blood Cancer Institute, Denver, Colorado."
],
[
"aff4",
"Sarah Cannon Research Institute and Tennessee Oncology ... | 2,022 | 01-8-2022 | 11-8-2022 | Research Article; Epigenetics; Hematological Cancers; Lymphomas; Clinical Trial Results; Phase I clinical trials; Small Molecule Agents; Epigenetic-Targeted Agents | null | Authors’ Disclosures
K.A. Blum reports grants from Constellation Pharmaceuticals during the conduct of the study. J.G. Supko reports other from Constellation Pharmaceuticals during the conduct of the study. M.B. Maris reports other from Constellation Pharmaceuticals during the conduct of the study. I.W. Flinn reports g... | [
{
"ref_id": "bib1",
"pmid_cited": "24751816",
"doi_cited": "",
"article_title": "Targeting bromodomains: epigenetic readers of lysine acetylation",
"name": "P Filippakopoulos; S Knapp",
"year": "2014",
"journal": "Nat Rev Drug Discov",
"journal_type": "journal"
},
{
"ref_id":... | CC BY | no | |
[
{
"type": "text",
"content": "Discounting money and health effects from communicable and noncommunicable diseases in Thailand"
}
] | The purpose of this study was to determine the discount rates for money and health outcomes in the Thai context, including the discount rates for communicable and non-communicable diseases. Moreover, this study aimed to explore the socio-demographic characteristics that influence discounting. The computer-based experim... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "Introduction",
"paragraphs": [
{
"aggregated_text": "Discounting is a method of adjusting the future costs and benefits of healthcare interventions such as devices, medicines, vaccines, procedures, and healthcare systems to their pre... | Scientific Reports | 36849620 | PMC9969024 | 10.1038/s41598-023-30559-2 | 30559 | [
[
"Yadee",
"Jirawit",
"Aff1"
],
[
"Yadee",
"Jirawit",
"Aff2"
],
[
"Yadee",
"Jirawit",
"Aff3"
],
[
"Permsuwan",
"Unchalee",
"Aff2"
],
[
"Permsuwan",
"Unchalee",
"Aff3"
],
[
"Guntawongwan",
"Kansinee",
"Aff4"
],
[
"Him... | [
[
"Aff1",
"grid.7132.7 0000 0000 9039 7662 Degree Program in Pharmacy, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand"
],
[
"Aff2",
"grid.7132.7 0000 0000 9039 7662 Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand"
... | 2,023 | 01-01-2023 | 27-2-2023 | Article | null | Competing interests
The authors declare no competing interests. | [
{
"ref_id": "CR1",
"pmid_cited": "",
"doi_cited": "",
"article_title": "",
"name": "MF Drummond; MJ Sculpher; K Claxton; GL Stoddart; GW Torrance",
"year": "2015",
"journal": "Methods for the Economic Evaluation of Health Care Programmes",
"journal_type": "book"
},
{
"ref_id"... | CC BY | no |
[
{
"type": "text",
"content": "Endoscopic surgery suturing techniques: a randomized study on learning"
}
] | Background Surgeons have widely adopted endoscopic suturing techniques using conventional laparoscopic instruments and the more advanced robotic systems. The FlexDex is a novel articulating laparoscopic needle driver providing enhanced dexterity in laparoscopic surgery. This study evaluates and compares the learning cu... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "Background",
"paragraphs": [
{
"aggregated_text": "Over the years constant innovation and technological advancement have facilitated surgeons to expand their practice of laparoscopic surgery [ 1 – 8 ]. Nonetheless, laparoscopic intra... | BMC Surgery | 35172810 | PMC8851769 | 10.1186/s12893-022-01513-2 | 1513 | [
[
"Voskens",
"F. J.",
"Aff1"
],
[
"Voskens",
"F. J.",
"Aff3"
],
[
"van der Schans",
"E. M.",
"Aff1"
],
[
"van der Schans",
"E. M.",
"Aff3"
],
[
"Ruurda",
"J. P.",
"Aff2"
],
[
"Broeders",
"I. A. M. J.",
"Aff1"
],
[
"B... | [
[
"Aff1",
"grid.414725.1 0000 0004 0368 8146 Department of Surgery, Meander Medical Center, Maatweg 3, Amersfoort, The Netherlands"
],
[
"Aff2",
"grid.7692.a 0000000090126352 Department of Gastro-Intestinal and Oncologic Surgery, University Medical Center, Utrecht, The Netherlands"
... | 2,022 | 01-01-2022 | 17-2-2022 | Research Article | null | Competing interests
Ivo A.M.J. Broeders is a consultant for Johnson & Johnson and Intuitive Surgical. Jelle P. Ruurda is a consultant for Intuitive Surgical. Frank J. Voskens and Emma M. van der Schans have no conflicts of interest or financial ties to disclose. | [
{
"ref_id": "CR1",
"pmid_cited": "25958296",
"doi_cited": "",
"article_title": "Open versus laparoscopic cholecystectomy in acute cholecystitis. Systematic review and meta-analysis",
"name": "F Coccolini; ",
"year": "2015",
"journal": "Int J Surg",
"journal_type": "journal"
},
{
... | CC BY | no |
[{"type":"text","content":"Scaling up of Eco-Bio-Social Strategy to Control"},{"type":"text","conten(...TRUNCATED) | "Aedes aegypti is a cosmopolitan vector for arboviruses dengue, Zika and chikungunya, disseminated i(...TRUNCATED) | [] | [] | [{"order":"1","subsections":[],"section_title":"1. Introduction","paragraphs":[{"aggregated_text":"M(...TRUNCATED) | International Journal of Environmental Research and Public Health | 33572650 | PMC7908398 | 10.3390/ijerph18031278 | ijerph-18-01278 | [["de Macêdo","Suyanne Freire","af1-ijerph-18-01278"],["de Macêdo","Suyanne Freire","af2-ijerph-18(...TRUNCATED) | [["af1-ijerph-18-01278","Collective Health Postgraduate Program, State University of Ceará, Fortale(...TRUNCATED) | 2,021 | 01-2-2021 | 31-1-2021 | Study Protocol | null | "Conflicts of Interest\nThe authors declare no conflict of interest. The funders had no role in the (...TRUNCATED) | [{"ref_id":"B1-ijerph-18-01278","pmid_cited":"23563266","doi_cited":"","article_title":"The global d(...TRUNCATED) | CC BY | no |
[{"type":"text","content":"Nurse-led, telephone-based secondary preventive follow-up benefits stroke(...TRUNCATED) | "Background The objective of this study was to analyze the impact of two forms of secondary prevent(...TRUNCATED) | [] | [] | [{"order":"1","subsections":[],"section_title":"Background","paragraphs":[{"aggregated_text":"Patien(...TRUNCATED) | Trials | 30646948 | PMC6334622 | 10.1186/s13063-018-3131-4 | 3131 | [["Irewall","Anna-Lotta","Aff1"],["Ögren","Joachim","Aff1"],["Bergström","Lisa","Aff1"],["Laurell"(...TRUNCATED) | [["Aff1","0000 0001 1034 3451 grid.12650.30 Department of Public Health and Clinical Medicine, (...TRUNCATED) | 2,019 | 01-01-2019 | 15-1-2019 | Research | null | "Ethics approval and consent to participate\nThe Regional Ethics Committee in Umeå approved the NAI(...TRUNCATED) | [{"ref_id":"CR1","pmid_cited":"21454819","doi_cited":"","article_title":"Risk and cumulative risk of(...TRUNCATED) | CC BY | no |
[{"type":"text","content":"Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose (...TRUNCATED) | "Abstract Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profo(...TRUNCATED) | [] | [] | [{"order":"1","subsections":[],"section_title":"Introduction","paragraphs":[{"aggregated_text":"Lyse(...TRUNCATED) | Psychopharmacology | 31853557 | PMC7036065 | 10.1007/s00213-019-05417-7 | 5417 | [["Family","Neiloufar","Aff1"],["Maillet","Emeline L.","Aff1"],["Williams","Luke T. J.","Aff1"],["Kr(...TRUNCATED) | [["Aff1","Eleusis Benefit Corporation, New York, NY USA"],["Aff2","grid.7445.2 0000 0001 2113 8111 (...TRUNCATED) | 2,020 | 01-01-2020 | 18-12-2019 | Original Investigation | null | Conflict of interest
All authors were paid consultants of Eleusis Benefit Corporation. | [{"ref_id":"CR1","pmid_cited":"","doi_cited":"10.1016/j.biopsych.2019.03.876","article_title":"S125.(...TRUNCATED) | CC BY | no |
[{"type":"text","content":"Impact of Vitamin E supplementation on vascular function in haptoglobin g(...TRUNCATED) | "Aims Vitamin E (Vit-E) may preferentially improve cardiovascular risk in haptoglobin 2-2 (Hp2-2) ge(...TRUNCATED) | [] | [] | [{"order":"1","subsections":[],"section_title":"Introduction","paragraphs":[{"aggregated_text":"Type(...TRUNCATED) | Nutrition & Diabetes | 32341356 | PMC7186220 | 10.1038/s41387-020-0116-7 | 116 | [["Dalan","Rinkoo","Aff1"],["Dalan","Rinkoo","Aff2"],["Dalan","Rinkoo","Aff3"],["Goh","Liuh Ling","A(...TRUNCATED) | [["Aff1","grid.240988.f Tan Tock Seng Hospital, Singapore, Singapore"],["Aff2","grid.59025.3b 00(...TRUNCATED) | 2,020 | 01-01-2020 | 27-4-2020 | Article | null | Conflict of interest
The authors declare that they have no conflict of interest. | [{"ref_id":"CR1","pmid_cited":"20609967","doi_cited":"","article_title":"Diabetes mellitus, fasting (...TRUNCATED) | CC BY | no |
[{"type":"text","content":"Effect of dolutegravir on folate, vitamin B12 and mean corpuscular volume(...TRUNCATED) | "Abstract Introduction Dolutegravir‐based antiretroviral therapy (ART) is the preferred antiretrov(...TRUNCATED) | [] | [] | [{"order":"1","subsections":[],"section_title":"INTRODUCTION","paragraphs":[{"aggregated_text":"Dolu(...TRUNCATED) | Journal of the International AIDS Society | 37766505 | PMC10534059 | 10.1002/jia2.26174 | JIA226174 | [["Barlow‐Mosha","Linda Namutebi","jia226174-aff-0001"],["Ahimbisibwe","Grace Miriam","jia226174-a(...TRUNCATED) | [["jia226174-aff-0001","Makerere University‐Johns Hopkins University (MU‐JHU) Research Collabora(...TRUNCATED) | 2,023 | 01-9-2023 | 27-9-2023 | Research Article; Research Articles | null | "COMPETING INTERESTS\nAT has received funding for serving on a ViiV Healthcare advisory board with p(...TRUNCATED) | [{"ref_id":"jia226174-bib-0001","pmid_cited":"34965338","doi_cited":"","article_title":"Dolutegravir(...TRUNCATED) | CC BY | no |
[{"type":"text","content":"Laparoscopic sacrohysteropexy versus vaginal hysterectomy and apical susp(...TRUNCATED) | "Introduction and hypothesis Laparoscopic mesh sacrohysteropexy offers a uterine-sparing alternative(...TRUNCATED) | [] | [] | [{"order":"1","subsections":[],"section_title":"Introduction","paragraphs":[{"aggregated_text":"A wo(...TRUNCATED) | International Urogynecology Journal | 34424347 | PMC9270299 | 10.1007/s00192-021-04932-6 | 4932 | [["Izett-Kay","Matthew L.","Aff1"],["Izett-Kay","Matthew L.","Aff2"],["Rahmanou","Philip","Aff3"],["(...TRUNCATED) | [["Aff1","grid.410556.3 0000 0001 0440 1440 Department of Urogynaecology, Women’s Centre, The Jo(...TRUNCATED) | 2,022 | 01-01-2022 | 23-8-2021 | Original Article | null | Conflicts of interest
None. | [{"ref_id":"CR1","pmid_cited":"20966694","doi_cited":"","article_title":"Lifetime risk of undergoing(...TRUNCATED) | CC BY | no |
[{"type":"text","content":"Randomized clinical trial on the use of a colon-occlusion device to assis(...TRUNCATED) | "Background Transrectal Natural Orifice Transluminal Endoscopic Surgery is currently limited by the (...TRUNCATED) | [] | [] | [{"order":"1","subsections":[{"order":"1.1","subsections":[],"section_title":"Coloshield device","pa(...TRUNCATED) | Surgical Endoscopy | 32968914 | PMC8346441 | 10.1007/s00464-020-07992-9 | 7992 | [["Cordewener","Carolin","Aff1"],["Zürcher","Manuel","Aff2"],["Müller","Philip C.","Aff3"],["Müll(...TRUNCATED) | [["Aff1","Pelvic Floor Unit, Clarunis, University Center for Gastrointestinal and Liver Diseases, 40(...TRUNCATED) | 2,021 | 01-01-2021 | 23-9-2020 | Article | null | "Disclosures\nThe Coloshield devices used in this trial were provided at no costs by A.M.I, Feldkirc(...TRUNCATED) | [{"ref_id":"CR1","pmid_cited":"21471754","doi_cited":"","article_title":"Transanal endoscopic micros(...TRUNCATED) | CC BY | no |
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