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[
{
"type": "text",
"content": "A Phase I Study of Pelabresib (CPI-0610), a Small-Molecule Inhibitor of BET Proteins, in Patients with Relapsed or Refractory Lymphoma"
}
] | Purpose: NF-κB, a transcription factor essential for inflammatory responses, is constitutively activated in many lymphomas. In preclinical studies, pelabresib (CPI-0610), an investigational (BET) bromodomain inhibitor, downregulated NF-κB signaling and demonstrated antitumor activity in vitro . Here we report the safet... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "Introduction",
"paragraphs": [
{
"aggregated_text": "Bromodomain and extraterminal domain (BET) proteins include a family of four related proteins (BRD2, BRD3, BRD4, and BRDT), each containing two tandem amino-terminal bromodomains (... | Cancer Research Communications | PMC10010313 | 10.1158/2767-9764.CRC-22-0060 | CRC-22-0060 | [
[
"Blum",
"Kristie A.",
"aff1"
],
[
"Supko",
"Jeffrey G.",
"aff2"
],
[
"Maris",
"Michael B.",
"aff3"
],
[
"Flinn",
"Ian W.",
"aff4"
],
[
"Goy",
"Andre",
"aff5"
],
[
"Younes",
"Anas",
"aff6"
],
[
"Bobba",
"Suresh"... | [
[
"aff1",
"Emory University School of Medicine, Atlanta, Georgia."
],
[
"aff2",
"Massachusetts General Hospital, Boston, Massachusetts."
],
[
"aff3",
"Colorado Blood Cancer Institute, Denver, Colorado."
],
[
"aff4",
"Sarah Cannon Research Institute and Tennessee Oncology ... | 2,022 | 01-8-2022 | 11-8-2022 | Research Article; Epigenetics; Hematological Cancers; Lymphomas; Clinical Trial Results; Phase I clinical trials; Small Molecule Agents; Epigenetic-Targeted Agents | null | Authors’ Disclosures
K.A. Blum reports grants from Constellation Pharmaceuticals during the conduct of the study. J.G. Supko reports other from Constellation Pharmaceuticals during the conduct of the study. M.B. Maris reports other from Constellation Pharmaceuticals during the conduct of the study. I.W. Flinn reports g... | [
{
"ref_id": "bib1",
"pmid_cited": "24751816",
"doi_cited": "",
"article_title": "Targeting bromodomains: epigenetic readers of lysine acetylation",
"name": "P Filippakopoulos; S Knapp",
"year": "2014",
"journal": "Nat Rev Drug Discov",
"journal_type": "journal"
},
{
"ref_id":... | CC BY | no | |
[
{
"type": "text",
"content": "Discounting money and health effects from communicable and noncommunicable diseases in Thailand"
}
] | The purpose of this study was to determine the discount rates for money and health outcomes in the Thai context, including the discount rates for communicable and non-communicable diseases. Moreover, this study aimed to explore the socio-demographic characteristics that influence discounting. The computer-based experim... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "Introduction",
"paragraphs": [
{
"aggregated_text": "Discounting is a method of adjusting the future costs and benefits of healthcare interventions such as devices, medicines, vaccines, procedures, and healthcare systems to their pre... | Scientific Reports | 36849620 | PMC9969024 | 10.1038/s41598-023-30559-2 | 30559 | [
[
"Yadee",
"Jirawit",
"Aff1"
],
[
"Yadee",
"Jirawit",
"Aff2"
],
[
"Yadee",
"Jirawit",
"Aff3"
],
[
"Permsuwan",
"Unchalee",
"Aff2"
],
[
"Permsuwan",
"Unchalee",
"Aff3"
],
[
"Guntawongwan",
"Kansinee",
"Aff4"
],
[
"Him... | [
[
"Aff1",
"grid.7132.7 0000 0000 9039 7662 Degree Program in Pharmacy, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand"
],
[
"Aff2",
"grid.7132.7 0000 0000 9039 7662 Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand"
... | 2,023 | 01-01-2023 | 27-2-2023 | Article | null | Competing interests
The authors declare no competing interests. | [
{
"ref_id": "CR1",
"pmid_cited": "",
"doi_cited": "",
"article_title": "",
"name": "MF Drummond; MJ Sculpher; K Claxton; GL Stoddart; GW Torrance",
"year": "2015",
"journal": "Methods for the Economic Evaluation of Health Care Programmes",
"journal_type": "book"
},
{
"ref_id"... | CC BY | no |
[
{
"type": "text",
"content": "Endoscopic surgery suturing techniques: a randomized study on learning"
}
] | Background Surgeons have widely adopted endoscopic suturing techniques using conventional laparoscopic instruments and the more advanced robotic systems. The FlexDex is a novel articulating laparoscopic needle driver providing enhanced dexterity in laparoscopic surgery. This study evaluates and compares the learning cu... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "Background",
"paragraphs": [
{
"aggregated_text": "Over the years constant innovation and technological advancement have facilitated surgeons to expand their practice of laparoscopic surgery [ 1 – 8 ]. Nonetheless, laparoscopic intra... | BMC Surgery | 35172810 | PMC8851769 | 10.1186/s12893-022-01513-2 | 1513 | [
[
"Voskens",
"F. J.",
"Aff1"
],
[
"Voskens",
"F. J.",
"Aff3"
],
[
"van der Schans",
"E. M.",
"Aff1"
],
[
"van der Schans",
"E. M.",
"Aff3"
],
[
"Ruurda",
"J. P.",
"Aff2"
],
[
"Broeders",
"I. A. M. J.",
"Aff1"
],
[
"B... | [
[
"Aff1",
"grid.414725.1 0000 0004 0368 8146 Department of Surgery, Meander Medical Center, Maatweg 3, Amersfoort, The Netherlands"
],
[
"Aff2",
"grid.7692.a 0000000090126352 Department of Gastro-Intestinal and Oncologic Surgery, University Medical Center, Utrecht, The Netherlands"
... | 2,022 | 01-01-2022 | 17-2-2022 | Research Article | null | Competing interests
Ivo A.M.J. Broeders is a consultant for Johnson & Johnson and Intuitive Surgical. Jelle P. Ruurda is a consultant for Intuitive Surgical. Frank J. Voskens and Emma M. van der Schans have no conflicts of interest or financial ties to disclose. | [
{
"ref_id": "CR1",
"pmid_cited": "25958296",
"doi_cited": "",
"article_title": "Open versus laparoscopic cholecystectomy in acute cholecystitis. Systematic review and meta-analysis",
"name": "F Coccolini; ",
"year": "2015",
"journal": "Int J Surg",
"journal_type": "journal"
},
{
... | CC BY | no |
[
{
"type": "text",
"content": "Scaling up of Eco-Bio-Social Strategy to Control"
},
{
"type": "text",
"content": "Aedes aegypti"
},
{
"type": "text",
"content": "in Highly Vulnerable Areas in Fortaleza, Brazil: A Cluster, Non-Randomized Controlled Trial Protocol"
}
] | Aedes aegypti is a cosmopolitan vector for arboviruses dengue, Zika and chikungunya, disseminated in all Brazilian states. The Eco-Bio-Social (EBS) strategy is vital in Aedes aegypti control as it mobilizes stakeholders (government, professionals, society, and academics) to promote healthy environments. This paper desc... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "1. Introduction",
"paragraphs": [
{
"aggregated_text": "Millions of people get sick and die from diseases transmitted by Aedes aegypti . For example, a study on dengue’s public health burden in 2010 estimated about 390 million Dengue... | International Journal of Environmental Research and Public Health | 33572650 | PMC7908398 | 10.3390/ijerph18031278 | ijerph-18-01278 | [
[
"de Macêdo",
"Suyanne Freire",
"af1-ijerph-18-01278"
],
[
"de Macêdo",
"Suyanne Freire",
"af2-ijerph-18-01278"
],
[
"Silva",
"Kellyanne Abreu",
"af1-ijerph-18-01278"
],
[
"de Vasconcelos",
"Renata Borges",
"af1-ijerph-18-01278"
],
[
"de Sousa",
... | [
[
"af1-ijerph-18-01278",
"Collective Health Postgraduate Program, State University of Ceará, Fortaleza 60714-903, Brazil; kellyanneabreu@gmail.com (K.A.S.); renatinhaam28@gmail.com (R.B.d.V.); izasousa222@gmail.com (I.V.d.S.); lyvia_mesquita@hotmail.com (L.P.S.M.); robertadumaia@gmail.com (R.D.M.B... | 2,021 | 01-2-2021 | 31-1-2021 | Study Protocol | null | Conflicts of Interest
The authors declare no conflict of interest. The funders had no role in the study’s design; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. | [
{
"ref_id": "B1-ijerph-18-01278",
"pmid_cited": "23563266",
"doi_cited": "",
"article_title": "The global distribution and burden of dengue",
"name": "S. Bhatt; P.W. Gething; O.J. Brady; J.P. Messina; A.W. Farlow; C.L. Moyes; J.M. Drake; J.S. Brownstein; A.G. Hoen; O. Sankoh; ",
"year": "201... | CC BY | no |
[
{
"type": "text",
"content": "Nurse-led, telephone-based secondary preventive follow-up benefits stroke/TIA patients with low education: a randomized controlled trial sub-study"
}
] | Background The objective of this study was to analyze the impact of two forms of secondary preventive follow-up on the association between education level and levels of blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) after stroke/transient ischemic attack (TIA). Methods We included a population-base... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "Background",
"paragraphs": [
{
"aggregated_text": "Patients with a previous stroke or transient ischemic attack (TIA) are at high risk of subsequent cardiovascular events, including stroke [ 1 – 4 ], myocardial infarction [ 2 , 3 , 5... | Trials | 30646948 | PMC6334622 | 10.1186/s13063-018-3131-4 | 3131 | [
[
"Irewall",
"Anna-Lotta",
"Aff1"
],
[
"Ögren",
"Joachim",
"Aff1"
],
[
"Bergström",
"Lisa",
"Aff1"
],
[
"Laurell",
"Katarina",
"Aff2"
],
[
"Söderström",
"Lars",
"Aff3"
],
[
"Mooe",
"Thomas",
"Aff1"
]
] | [
[
"Aff1",
"0000 0001 1034 3451 grid.12650.30 Department of Public Health and Clinical Medicine, Östersund, Umeå University, Umeå, Sweden"
],
[
"Aff2",
"0000 0001 1034 3451 grid.12650.30 Department of Pharmacology and Clinical Neuroscience, Östersund, Umeå University, Umeå, Sweden"
... | 2,019 | 01-01-2019 | 15-1-2019 | Research | null | Ethics approval and consent to participate
The Regional Ethics Committee in Umeå approved the NAILED study on October 28, 2009 (Dnr 09-142 N). All participants provided written informed consent.
Consent for publication
Not applicable.
Competing interests
The authors declare that they have no competing interests.
Publis... | [
{
"ref_id": "CR1",
"pmid_cited": "21454819",
"doi_cited": "",
"article_title": "Risk and cumulative risk of stroke recurrence: a systematic review and meta-analysis",
"name": "KM Mohan; CD Wolfe; AG Rudd; PU Heuschmann; PL Kolominsky-Rabas; AP Grieve",
"year": "2011",
"journal": "Stroke"... | CC BY | no |
[
{
"type": "text",
"content": "Safety, tolerability, pharmacokinetics, and pharmacodynamics of low dose lysergic acid diethylamide (LSD) in healthy older volunteers"
}
] | Abstract Research has shown that psychedelics, such as lysergic acid diethylamide (LSD), have profound anti-inflammatory properties mediated by 5-HT 2A receptor signaling, supporting their evaluation as a therapeutic for neuroinflammation associated with neurodegenerative disease. Objective This study evaluated the saf... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "Introduction",
"paragraphs": [
{
"aggregated_text": "Lysergic acid diethylamide (LSD) is a classic serotonergic hallucinogenic (psychedelic) drug from the ergoline family. LSD has a complex polypharmacology, interacting with essentia... | Psychopharmacology | 31853557 | PMC7036065 | 10.1007/s00213-019-05417-7 | 5417 | [
[
"Family",
"Neiloufar",
"Aff1"
],
[
"Maillet",
"Emeline L.",
"Aff1"
],
[
"Williams",
"Luke T. J.",
"Aff1"
],
[
"Krediet",
"Erwin",
"Aff1"
],
[
"Carhart-Harris",
"Robin L.",
"Aff2"
],
[
"Williams",
"Tim M.",
"Aff3"
],
[
... | [
[
"Aff1",
"Eleusis Benefit Corporation, New York, NY USA"
],
[
"Aff2",
"grid.7445.2 0000 0001 2113 8111 Imperial College London, London, UK"
],
[
"Aff3",
"grid.5337.2 0000 0004 1936 7603 Bristol University, Bristol, UK"
],
[
"Aff4",
"grid.279863.1 0000 0000 8954 ... | 2,020 | 01-01-2020 | 18-12-2019 | Original Investigation | null | Conflict of interest
All authors were paid consultants of Eleusis Benefit Corporation. | [
{
"ref_id": "CR1",
"pmid_cited": "",
"doi_cited": "10.1016/j.biopsych.2019.03.876",
"article_title": "S125. Subjective and Behavioral Effects of Microdoses of LSD in Healthy Human Volunteers",
"name": "Anya Bershad; Scott Schepers; Michael Bremmer; Harriet de Wit",
"year": "2019",
"journ... | CC BY | no |
[
{
"type": "text",
"content": "Impact of Vitamin E supplementation on vascular function in haptoglobin genotype stratified diabetes patients (EVAS Trial): a randomised controlled trial"
}
] | Aims Vitamin E (Vit-E) may preferentially improve cardiovascular risk in haptoglobin 2-2 (Hp2-2) genotype diabetes individuals. We studied the impact of Vit-E supplementation on vascular function in diabetes individuals stratified by haptoglobin genotype in Singapore. Methods In this 24-week, double blind, placebo-cont... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "Introduction",
"paragraphs": [
{
"aggregated_text": "Type 2 Diabetes Mellitus (T2DM) leads to a high disease burden due to vascular complications 1 . The dysmetabolic state in T2DM fuels low-grade inflammation and oxidative stress, t... | Nutrition & Diabetes | 32341356 | PMC7186220 | 10.1038/s41387-020-0116-7 | 116 | [
[
"Dalan",
"Rinkoo",
"Aff1"
],
[
"Dalan",
"Rinkoo",
"Aff2"
],
[
"Dalan",
"Rinkoo",
"Aff3"
],
[
"Goh",
"Liuh Ling",
"Aff1"
],
[
"Lim",
"Chien Joo",
"Aff1"
],
[
"Seneviratna",
"Aruni",
"Aff1"
],
[
"Liew",
"Huiling"... | [
[
"Aff1",
"grid.240988.f Tan Tock Seng Hospital, Singapore, Singapore"
],
[
"Aff2",
"grid.59025.3b 0000 0001 2224 0361 Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore"
],
[
"Aff3",
"grid.4280.e 0000 0001 2180 6431 Yong Loo Lin Scho... | 2,020 | 01-01-2020 | 27-4-2020 | Article | null | Conflict of interest
The authors declare that they have no conflict of interest. | [
{
"ref_id": "CR1",
"pmid_cited": "20609967",
"doi_cited": "",
"article_title": "Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Emerging Risk Factors Collaboration",
"name": "N Sarwar; ",
"year": ... | CC BY | no |
[
{
"type": "text",
"content": "Effect of dolutegravir on folate, vitamin B12 and mean corpuscular volume levels among children and adolescents with HIV: a sub‐study of the ODYSSEY randomized controlled trial"
}
] | Abstract Introduction Dolutegravir‐based antiretroviral therapy (ART) is the preferred antiretroviral treatment for children and adolescents living with HIV. A large surveillance study in Botswana previously raised concerns about an association between pre‐conception dolutegravir and neural tube defects. Before these c... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "INTRODUCTION",
"paragraphs": [
{
"aggregated_text": "Dolutegravir‐based antiretroviral therapy (ART) has become the preferred treatment option for children living with HIV due to superior efficacy and similar safety compared to non‐d... | Journal of the International AIDS Society | 37766505 | PMC10534059 | 10.1002/jia2.26174 | JIA226174 | [
[
"Barlow‐Mosha",
"Linda Namutebi",
"jia226174-aff-0001"
],
[
"Ahimbisibwe",
"Grace Miriam",
"jia226174-aff-0001"
],
[
"Chappell",
"Elizabeth",
"jia226174-aff-0002"
],
[
"Amuge",
"Pauline Mary",
"jia226174-aff-0003"
],
[
"Nanduudu",
"Annet",
... | [
[
"jia226174-aff-0001",
"Makerere University‐Johns Hopkins University (MU‐JHU) Research Collaboration Kampala Uganda"
],
[
"jia226174-aff-0002",
"MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology London UK"
],
[
"jia226174-aff-0003",
"Baylor Colleg... | 2,023 | 01-9-2023 | 27-9-2023 | Research Article; Research Articles | null | COMPETING INTERESTS
AT has received funding for serving on a ViiV Healthcare advisory board with payment made to the employer. Other authors have no conflict of interest to declare. | [
{
"ref_id": "jia226174-bib-0001",
"pmid_cited": "34965338",
"doi_cited": "",
"article_title": "Dolutegravir as first‐ or second‐line treatment for HIV‐1 infection in children",
"name": "",
"year": "2021",
"journal": "N Engl J Med",
"journal_type": "journal"
},
{
"ref_id": "ji... | CC BY | no |
[
{
"type": "text",
"content": "Laparoscopic sacrohysteropexy versus vaginal hysterectomy and apical suspension: 7-year follow-up of a randomized controlled trial"
}
] | Introduction and hypothesis Laparoscopic mesh sacrohysteropexy offers a uterine-sparing alternative to vaginal hysterectomy with apical suspension, although randomised comparative data are lacking. This study was aimed at comparing the long-term efficacy of laparoscopic mesh sacrohysteropexy and vaginal hysterectomy wi... | [] | [] | [
{
"order": "1",
"subsections": [],
"section_title": "Introduction",
"paragraphs": [
{
"aggregated_text": "A woman’s lifetime risk of surgery for pelvic organ prolapse (POP) is between 11% and 19% [ 1 ]. Rates of surgical intervention are predicted to increase [ 2 ] as populations age. ... | International Urogynecology Journal | 34424347 | PMC9270299 | 10.1007/s00192-021-04932-6 | 4932 | [
[
"Izett-Kay",
"Matthew L.",
"Aff1"
],
[
"Izett-Kay",
"Matthew L.",
"Aff2"
],
[
"Rahmanou",
"Philip",
"Aff3"
],
[
"Cartwright",
"Rufus J.",
"Aff1"
],
[
"Price",
"Natalia",
"Aff1"
],
[
"Jackson",
"Simon R.",
"Aff1"
]
] | [
[
"Aff1",
"grid.410556.3 0000 0001 0440 1440 Department of Urogynaecology, Women’s Centre, The John Radcliffe Hospital, Oxford University Hospitals, Headington, Oxford, OX3 9FR UK"
],
[
"Aff2",
"grid.83440.3b 0000000121901201 UCL EGA Institute for Women’s Health, University College Lon... | 2,022 | 01-01-2022 | 23-8-2021 | Original Article | null | Conflicts of interest
None. | [
{
"ref_id": "CR1",
"pmid_cited": "20966694",
"doi_cited": "",
"article_title": "Lifetime risk of undergoing surgery for pelvic organ prolapse",
"name": "FJ Smith; CD Holman; RE Moorin; N Tsokos",
"year": "2010",
"journal": "Obstet Gynecol",
"journal_type": "journal"
},
{
"ref... | CC BY | no |
[
{
"type": "text",
"content": "Randomized clinical trial on the use of a colon-occlusion device to assist rectal washout"
}
] | Background Transrectal Natural Orifice Transluminal Endoscopic Surgery is currently limited by the inherent risk of surgical site infection due to peritoneal contamination after rectotomy. Coloshield has been developed as a temporary colon occlusion device to facilitate rectal washout. However, effectiveness and safety... | [] | [] | [
{
"order": "1",
"subsections": [
{
"order": "1.1",
"subsections": [],
"section_title": "Coloshield device",
"paragraphs": [
{
"aggregated_text": "The principle of Coloshield (certified according to the CE number 0297 (Conformité Européeene), A.M.I.... | Surgical Endoscopy | 32968914 | PMC8346441 | 10.1007/s00464-020-07992-9 | 7992 | [
[
"Cordewener",
"Carolin",
"Aff1"
],
[
"Zürcher",
"Manuel",
"Aff2"
],
[
"Müller",
"Philip C.",
"Aff3"
],
[
"Müller-Stich",
"Beat P.",
"Aff4"
],
[
"Zerz",
"Andreas",
"Aff5"
],
[
"Linke",
"Georg R.",
"Aff2"
],
[
"Stein... | [
[
"Aff1",
"Pelvic Floor Unit, Clarunis, University Center for Gastrointestinal and Liver Diseases, 4002 Basel, Switzerland"
],
[
"Aff2",
"Department of Surgery, Spital Thun STS AG, Krankenhausstrasse 12, 3600 Thun, Switzerland"
],
[
"Aff3",
"grid.412004.3 0000 0004 0478 9977 Depart... | 2,021 | 01-01-2021 | 23-9-2020 | Article | null | Disclosures
The Coloshield devices used in this trial were provided at no costs by A.M.I, Feldkirch, Austria. No further compensations, however, were obtained. C. Cordewener, M. Zürcher, P.C. Müller, B.P.Müller-Stich, A. Zerz, G.R. Linke, and D.C.Steinemann have no conflicts of interest or financial ties to disclose. | [
{
"ref_id": "CR1",
"pmid_cited": "21471754",
"doi_cited": "",
"article_title": "Transanal endoscopic microsurgery for residual rectal cancer after neoadjuvant chemoradiation therapy is associated with significant immediate pain and hospital readmission rates",
"name": "RO Perez; A Habr-Gama; GP ... | CC BY | no |
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