Pubmed Text
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Collection of pubmed 2024 papers. • 11 items • Updated
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11098484 | UFT: mechanism of drug action. | The mechanism of action of fluorouracil (5-FU) and the oral fluoropyrimidines and the importance of biochemical modulation and inhibition of dihydropyrimidine dehydrogenase for oral application of the prodrugs of 5-FU are discussed. The regulation of thymidylate synthase, as well as its roles as a target for antineopla... |
11098485 | Oral DPD-inhibitory fluoropyrimidine drugs. | Over the past decade, increasing data have emphasized both the importance of dihydropyrimidine dehydrogenase (DPD), the initial, rate-limiting enzyme in the catabolism of fluorouracil (5-FU), and its role as a control step in 5-FU metabolism, regulating the availability of 5-FU for anabolism. It is now clear that DPD a... |
11098486 | UFT/leucovorin vs 5-FU/leucovorin in colon cancer. | Adjuvant chemotherapy has been shown to alter the natural history of resected colon cancer. Two regimens (fluorouracil [5-FU] plus leucovorin and 5-FU plus levamisole) have been found to prolong disease-free survival and overall survival in affected patients. parisons of these two regimens indicate that 5-FU plus leuco... |
11098487 | UFT/leucovorin plus irinotecan in advanced or metastatic colorectal cancer. | UFT (with leucovorin) and irinotecan both have single-agent activity in colorectal cancer, with non-cross-resistant mechanisms of action. Combining these drugs would be anticipated to increase response rates while maintaining the advantages of a regimen based on an orally administered fluoropyrimidine. This trial aims ... |
11098488 | UFT/leucovorin combined with mitomycin-C in metastatic colorectal Ca. | UFT is an investigational agent that may be useful treatment for colorectal carcinoma and other cancers for which fluorinated pyrimidines are a useful treatment. bination of continuous-infusion fluorouracil (5-FU) with leucovorin and mitomycin-C can significantly delay recurrence and may prolong life. UFT may be an att... |
11098489 | Impact of UFT on tumoral TS and DPD levels in colorectal cancer. | This was an open lable, pilot translational clinical pharmacology study of a brief (7 day) course of UFT, 300 mg/m2/day, bination with leucovorin, 90 mg/day, in six patients with newly diagnosed advanced colorectal cancer. The primary objectives of the study were to examine the impact of this treatment course on the UF... |
11098490 | UFT/leucovorin plus weekly irinotecan in advanced or metastatic colorectal cancer. | This is an open-label, nonrandomized phase I trial to determine the safety and maximum tolerated dose of irinotecan with a fixed dose of UFT plus oral leucovorin in patients with advanced or metastatic colorectal cancer. A secondary objective of the study is to determine the response rate in this patient population. Ad... |
11098491 | UFT plus leucovorin for metastatic colorectal cancer: Japanese experience. | In the United States and Europe, bination of oral UFT plus leucovorin has been reported to produce objective responses and survival rates similar to those achieved with standard intravenous 5-fluorouracil plus leucovorin in patients with metastatic colorectal cancer, with reduced toxicity. However, because knowledge an... |
11098492 | A phase I study. UFT/leucovorin combined with paclitaxel for anthracycline-pretreated advanced breast cancer. | Taxanes are the most active drugs in the treatment of metastatic breast and ovarian cancer. Weekly therapy with paclitaxel produces notable activity, with remarkably low toxicity. bination therapy with paclitaxel and fluorouracil (5-FU) exhibits high activity in anthracycline-pretreated breast cancer patients: recent s... |
11098493 | UFT/leucovorin plus bolus epirubicin and cyclophosphamide in advanced/metastatic breast cancer. | This article describes the design and early results of an open-label, nonrandomized phase I/II trial of oral UFT plus leucovorin therapy bination with bolus injections of epirubicin and cyclophosphamide in patients with advanced or metastatic breast cancer. This study was designed as a cohort dose-escalation study with... |
11098495 | A phase I study. Preoperative UFT/leucovorin and radiation therapy in rectal cancer. | The use bined modality regimens has been well established in the treatment of stages II and III rectal cancer. The mon chemotherapy regimens used include continuous-infusion 5-FU delivered with the help of a central venous catheter and the use of portable pumps. These regimens are expensive and can potentially develop ... |
11098494 | UFT/leucovorin plus vinorelbine combination for advanced breast cancer. | This phase I study was undertaken to define the maximum tolerated dose, the dose-limiting toxicity, and the mended dose of UFT plus leucovorin and vinorelbine bination treatment of patients with metastatic breast cancer previously treated with one chemotherapy regimen. The pharmacokinetics of UFT and vinorelbine were a... |
11098496 | Postoperative radiation therapy for rectal cancer combined with UFT/leucovorin. | bined-modality therapy with fluorouracil (5-FU) and radiation therapy is accepted practice for high-risk rectal cancer. Postoperative pelvic radiotherapy alone may improve pelvic control, but is not associated with an improvement in survival. Protracted infusional 5-FU has been associated with decreased tumor recurrenc... |
11098497 | UFT/leucovorin plus weekly paclitaxel in the treatment of solid tumors. | The palliation of symptoms and improvement of quality of life are important aspects of therapy in patients with incurable metastatic cancer. This article describes the preliminary results of a phase I study of uracil and tegafur, an orally available fluorouracil (5-FU) bined with oral leucovorin plus weekly intravenous... |
11098498 | UFT and its metabolites inhibit cancer-induced angiogenesis. Via a VEGF-related pathway. | Treatment with UFT for spontaneous lung metastasis of murine renal carcinoma (RENCA) after resection of the primary tumor has resulted in significant prolongation of the life span of tumor-bearing animals. UFT inhibited the growth of metastatic nodules in the lung, apparently via decreased density of microvessels in th... |
11098499 | UFT plus carboplatin for head and neck cancer. | Cisplatin plus fluorouracil (5-FU) is widely accepted as neoadjuvant and adjuvant chemotherapy in the treatment of head and neck squamous cell carcinoma; UFT is also an active agent against this disease. In the first retrospective study, we examined the efficacy of UFT as adjuvant chemotherapy in patients with maxillar... |
11098500 | A phase I study of paclitaxel, UFT, and leucovorin. | This phase I study examines the dose escalation of UFT given bination with fixed doses of oral leucovorin and weekly doses of paclitaxel in patients with metastatic solid tumor malignancies (excluding colorectal cancer). There are two main objectives for this study. The first is to determine both the maximum tolerated ... |
11098502 | Evaluation of adjuvant UFT for gastric cancer. | In a trial of adjuvant chemotherapy with mitomycin and 5-FU followed by oral UFT for T1 and T2 gastric cancer after curative gastrectomy, there was no significant difference in survival between the treated and control (surgery alone) groups (5-year survival rate, 82.9% control vs 85.8% treated). Although not significan... |
11098501 | UFT/leucovorin in advanced squamous cell carcinoma of the head and neck administered with radiotherapy. | This is an open-label, nonrandomized phase I study to determine the maximum tolerated dose and dose-limiting toxicity of UFT plus leucovorin when given itantly with hyperfractionated radiotherapy in patients with head and neck cancer. The study period is determined by the course of radiotherapy, which is given as 1.7 G... |
11098503 | A novel weekday-on/weekend-off UFT schedule. | In a step toward a clinical trial, the tumor response and survival of a weekday-on/weekend-off schedule of UFT pared with its conventional daily schedule in a cancer-bearing rat model. The dose-intensive schedule--600 mg of UFT for 5 days followed by 2 drug-free days--amounts to a weekly dose similar to the conventiona... |
11098504 | Irinotecan and UFT/leucovorin in patients with advanced cancers. | bination of irinotecan and fluorouracil (5-FU) is synergistic when applied to human colon cancer cell lines in vitro and appears to be schedule-dependent: maximal activity occurs when irinotecan is administered prior to 5-FU. In this phase I study, irinotecan is administered bination with UFT and leucovorin in patients... |
11098505 | Limited small-cell lung cancer: a potentially curable disease. | Patients with limited-stage small-cell carcinoma of the lung are treated bined-modality therapy with the intent to cure. Standard therapy consists of bination chemotherapy, thoracic irradiation, and for responders, prophylactic cranial irradiation. Despite this aggressive approach, too few patients achieve 5-year survi... |
11098508 | High-dose chemotherapy in poor-risk germ-cell tumors. | Testicular cancer is a highly curable cancer. However, 30% of patients are refractory to standard therapy and will need additional therapy. This article focuses on the use of high-dose chemotherapy in germ-cell tumors. High-dose chemotherapy use is discussed both in the refractory setting and as either first-salvage or... |
11098511 | Indications for selective neck dissection: when, how, and why. | Selective neck dissection is a procedure that is primarily indicated in patients with clinically negative nodal disease in which there is a high risk of occult metastases. Others have advocated its use for patients with positive nodes, although under very specific circumstances and bination with postoperative radiation... |
11098512 | Multidisciplinary management of pediatric soft-tissue sarcoma. | The management of pediatric soft-tissue as has improved drastically through the use of multimodal therapy. These tumors include as and as. Both are staged using physical, radiographic, and histologic evaluation, and both have intricate staging and grouping systems that correlate closely with prognosis. However, approac... |
11098513 | Follow-up care for cancer: making the benefits equal the cost. | Posttreatment follow-up is a staple of oncologic practice. Clinicians have traditionally presumed that close surveillance improves clinical e. However, new evidence reveals that frequent, procedure-intensive follow-up may provide no more significant benefit to patients than simpler approaches. Several recent consensus ... |
11098524 | Heart failure in women. | Heart failure affects more than 5 million Americans. Each year, about 400,000 individuals develop heart failure, making it the nation's most rapidly growing cardiac problem. Almost one third of these individuals have New York Heart Association Functional Class III or IV heart failure and are faced with progressive clin... |
11098525 | Optimum bedside cardiac monitoring. | Correct electrode placement is critical to obtaining accurate information from any monitoring lead. The choice of lead should be based on the goals of monitoring for a specific patient population and on the individual patient's clinical situation. When using a 5-wire monitoring cable, arm electrodes should be placed on... |
11098526 | Salt sensitivity and hypertension in African Americans: implications for cardiovascular nurses. | Hypertension is a major public health problem in the U.S. Salt sensitivity is an important factor associated with hypertension and plications, yet it has not been addressed in the nursing literature. Salt sensitivity is a directionally appropriate rise or fall in blood pressure when salt is added or removed, respective... |
11098533 | [Therapeutic potential of thrombopoietin]. | Thrombocytopenia induced by disease and/or chemotherapy is one of the plications in the treatment of patients with hemato-oncological malignancies. The discovery of Mpl ligand, a hematopoietic growth factor that stimulates megakaryopoiesis and thrombopoiesis lineage-specifically both in vitro and in preclinical models,... |
11098534 | Admission for syncope: evaluation, cost and prognosis. | Despite extensive in-hospital evaluation the cause of syncope remains unexplained in up to 40% of patients. |
11098535 | Seroprevalence of ehrlichiosis, Lyme borreliosis and tick-borne encephalitis infections in children and young adults in Slovenia. | Little is known about the seroprevalence of ehrlichiosis in adults and much less about the same in children. |
11098536 | Nontoxigenic sorbitol-fermenting Escherichia coli O157:H- associated with a family outbreak of diarrhoea. | A recent study from Germany reported the isolation of E. coli O157:H7/H- from patients with non-bloody diarrhoea and hemolytic uremic syndrome, questioning the role of Shiga toxin as the main trait of virulence for human disease. We isolated 6 sorbitol-fermenting E. coli O157:H- strains that do not contain Shiga toxin ... |
11098537 | [Importance of computer tomography in preoperative diagnostics of polyposis nasi]. | Computed tomography (CT) is a very important diagnostic tool prior to endoscopic nasal or paranasal sinus surgery. However, it is frequently notice during endonsal surgery of the paranasal sinuses, that the intraoperative results do pletely agree with the radiological ones. The objective of the present study was pare c... |
11098539 | [Heterotopic cystic pancreas as a growing submucous tumor close to the cardia of the stomach]. | Ectopic pancreas, presenting as a growing submucosal tumor, is a rarity in stomach surgery. Up to now, only about 250 cases of ectopic pancreas have been described. To our knowledge this is the first report of ectopic pancreas found near the cardia. A 52 year old female patient suffered from unclear upper abdominal dis... |
11098538 | Primary breast cancer of the vulva: a case report and review of the literature. | Since 1872, 40 cases of ectopic mammary gland tissue in the vulva have been reported in the literature. Out of these, 12 had a primary cancer in the ectopic breast tissue. Seven metastases of an orthotopic breast cancer have been found in this location. We are presenting the 20th case of cancerous breast tissue in the ... |
11098540 | [Myocardial contrast echocardiography. Research instrument or already clinical application?]. | Increasing interest has been focused on myocardial contrast echocardiography (MCE) since latest imaging technologies allow the detection of echocontrast agents within myocardial structures following intravenous injections. Although numerous studies on different aspects of pre-clinical and clinical applications have bee... |
11098542 | [Myocardial contrast echocardiography with harmonic power Doppler and lung traversing SHU 563A ultrasound contrast medium for imaging myocardial perfusion disorders]. | The current approach for the assessment of myocardial perfusion using contrast echocardiography involves black-and-white gray scale imaging in b-mode. For better appreciation of perfusion abnormalities, off-line postprocessing techniques including color encoding are used. In this study, we examined whether we could exp... |
11098541 | [Echocardiographic online quantification of left ventricular systolic function in children: comparison with conventional off-line determination]. | Accurate and efficient echocardiographic on-line determination of left ventricular volume would be advantageous in the care of children with congenital heart disease and children with hemodynamic instability. The prospective study was performed to evaluate the clinical usefulness of the on-line automatic border detecti... |
11098543 | [Assessment of myocardial vitality with dobutamine echocardiography: current review]. | Myocardial stunning (contractile dysfunction in the presence of normalized perfusion) and myocardial hibernation (contractile dysfunction matching reduced perfusion) have represented separate concepts of viable, but dyssynergic myocardium in the past. However, in vivo experimental and clinical work suggests that repeti... |
11098545 | [Indirect genotype analysis as a diagnostic procedure in Marfan syndrome]. | Marfan syndrome (MFS) is an autosomal dominant disorder of connective tissue characterized by skeletal, ocular and cardiovascular manifestations. The disease is caused by mutations in the FBN1 gene, encoding fibrillin, an ponent of elastic fibers. Diagnosis of Marfan syndrome is currently based on detailed clinical exa... |
11098546 | [Significance of matrix metalloproteinases in cardiovascular diseases]. | The cardiovascular interstitial space is posed of type I and III fibrillar collagens. Tissue structure, form and function are determined not only by the collagen content but also by the ratio of different collagens to each other. Matrix metalloproteinases are members of a family of secreted and membrane-bound enzymes t... |
11098544 | [Reconstruction of the bicuspid aortic valve]. | Reconstruction of a regurgitant bicuspid aortic valve is a new alternative to aortic valve replacement. With itant aortic root dilatation adequate reconstruction is feasible by valve-sparing aortic replacement. Between 10/95 and 02/00, 30 patients underwent reconstruction of a regurgitant bicuspid aortic valve. Additio... |
11098547 | [Aortic isthmus stenosis with open ductus Botalli as etiology of severe heart failure in a 36-year-old patient--case report of successful surgical treatment]. | We report on the history of a 36-year-old woman with untreated coarctation of the aorta and patent ductus arteriosus who developed refractory heart failure due to severely impaired left ventricular function. After coarctation repair and duct resection, left ventricular function improved to normal. Even in the presence ... |
11098549 | [Progression of an intramural hematoma to dissection]. | Intramural hematoma is a spontaneous, localized bleeding in the wall of the thoracic aorta without evidence of intimal tear. Clinically, intramural hematoma manifests itself as an acute thoracical pain in patients with hypertension and therefore shows parallels with the classical aortic dissection. In the literature th... |
11098548 | [Interventional therapy of aortic isthmus stenosis with concomitant thoracic aortic aneurysm with a stent graft]. | A 23 year old male presented with hypertension and a systolic murmur. ECG and echo revealed signs of left ventricular hypertrophy. Aortography showed aortic coarctation (delta p max. 40 mmHg) bination with an aneurysm originating from the coarcted segment distal from the origin of the left subclavian artery. Coarctatio... |
11098554 | [New ways of imaging diagnosis of the heart with electron beam tomography]. | Electron puted tomography is a noninvasive imaging tool for diagnosing heart disease. The method offers new insights into coronary heart disease, because the quantification of coronary artery calcification provides a fast, low-risk and cost efficient estimation of coronary risk with greater prognostic power than tradit... |
11098553 | [Pathogenesis of coronary disease]. | Being overweight (OW) was recognized very early as a risk factor for coronary heart disease (CHD). Its significance in the pathogenesis of CHD has been strengthened by observations showing that OW is responsible for the development of diabetes, hypertension and lipid disorders due to its induction of insulin resistance... |
11098552 | An overview of the evolution of the atherosclerotic plaque: from fatty streak to plaque rupture and thrombosis. | Today, there is a wealth of information concerning the chronology of the cellular and molecular events associated with the development of cardiovascular diseases. It is now clear that atherosclerosis is largely a result of a dysregulated fibroproliferative inflammatory response [1]. Treatment of cardiovascular disease ... |
11098555 | [New strategies in the treatment of restenosis]. | Twenty-three years after introduction of coronary angioplasty (PTCA), the inhibition of restenosis formation continues to be the major challenge for the interventional cardiologist. About 35-50% of all patients undergoing PTCA develop a renarrowing of the intravascular lumen within the following six months. The use of ... |
11098557 | [Percutaneous myocardial laser revascularization (PMR), a new therapeutic procedure for patients with refractory angina pectoris]. | In patients with severe angina pectoris due to coronary artery disease, who are not candidates for either percutaneous coronary angioplasty or coronary artery bypass surgery, transmyocardial laser revascularization (TMR) often leads to improvement of clinical symptoms and increased exercise capacity. One drawback of TM... |
11098556 | [Neoangiogenesis by local gene therapy: a new therapeutic concept in the treatment of coronary disease]. | This article presents the results of our initial clinical experience with the human growth factor FGF-1 as applied to the ischemic human myocardium. After pletion of extensive preliminary animal experiments, the human angiogenetic growth factor FGF-1, obtained from a genetically transformed strain of E. coli was introd... |
11098558 | [Multiple myocardial revascularization on the beating heart: risks, benefits and outlooks]. | Avoidance of extracorporeal circulation during beating heart surgery (OP CAB = Off-Pump Coronary Artery Bypass Surgery) for aortocoronary bypass grafting (ACBG) is gaining increasing importance in modern cardiac surgery. With the development of new mechanical stabilization devices, the revascularization of the posterio... |
11098559 | Surgery of acute type A dissection: what have we learned during the past 25 years? | Every acute dissection involving the ascending aorta (Stanford type A) must undergo emergency surgical repair. However, the surgical techniques must vary according to the clinical presentation of the patients or the anatomical patterns observed. Furthermore, surgery is generally difficult because of the poor condition ... |
11098560 | [Heart failure and sudden cardiac death: pharmacological and nonpharmacological treatment possibilities from the viewpoint of the rhythmologist]. | Recent multicenter studies have shown that the implantable cardioverter defibrillator (ICD) is pared to antiarrhythmic agents after sudden cardiac death (SCD) in patients with congestive heart failure. Further ICD studies have to be performed for primary prevention of SCD in patients with heart failure. Primary prevent... |
11098561 | [Therapeutic inhibition of platelets in a acute coronary syndrome and in coronary intervention: mechanisms and clinical results]. | Platelets play a crucial role in the pathogenesis of atherosclerosis and especially in the final ischemic consequences such as acute coronary syndromes. Furthermore, platelets are central mediators of acute or plications of coronary interventions. Therefore, therapeutic inhibition of platelet function is of major inter... |
11098562 | Left ventricular restoration by endoventricular circular patch plasty (EVCPP). | The Endoventricular Circular Patch Plasty technique, developed to reorganize the left ventricular cavity after post-ischemic modification, is described as it has been used since 1984. Experience of more than 900 cases demonstrates the efficiency of the technique in terms of left ventricular shape, left ventricular perf... |
11098563 | [Reverse remodeling by surgery--fact or fiction?]. | Mortality of chronic heart failure in industrial countries remains unacceptably high despite advances in medical therapy. Heart transplantation, the gold standard in the treatment of end-stage heart failure is reserved for only a few patients because of the shortage of donor hearts. Surgical alternatives to transplanta... |
11098565 | [Advances and perspectives in mechanical heart assist]. | Mechanical circulatory support devices were first developed to permanently replace the failing heart. Today, however, the majority of these devices are used as a mechanical bridge in patients awaiting heart transplantation. With this indication, important information on using mechanical assist devices has been assemble... |
11098564 | [Advances and perspectives of heart-lung transplantation]. | Thoracic organ transplantation has evolved as standard therapy in end-stage cardiac and pulmonary failure. Meanwhile more than 50,000 heart, 2500 heart-lung and 10,000 lung transplantations have been performed worldwide. Improvements in patient selection as well as in the postoperative management have led to 1-year sur... |
11098566 | [Robotic-guided techniques in heart surgery]. | The rigid design of conventional endoscopic instruments with limited degrees of freedom has not allowed for endoscopic cardiac surgery. Using a surgical telemanipulation system that is operated from a master console, endoscopic coronary artery bypass grafting and mitral valve repair can be performed with high precision... |
11098567 | Loss of sinus compliance, cause of degenerative aortic valve disease, and early failure of biological valves. | Loss pliance of aortic sinuses due to aging or graft replacement causes significant aortic valve leaflet dysfunction. This event leads to stress overload and induces degenerative changes in the patient's (natural or bioprosthetic) valve and unfavorably influences leaflet longevity. |
11098568 | [Reconstructive surgery of the aortic root]. | Surgical treatment of proximal aortic disease traditionally consists posite replacement of valve and aorta. Recent reconstructive procedures on the aortic root allow for treatment of aortic dilatation and itant aortic valve regurgitation without the associated disadvantages of mechanical heart valves. From 10/95 to 09/... |
11098570 | [Lymph nodes and malignant tumors]. | The planning of locoregional tumor therapy (radical surgical resection, curative radiotherapy) is based on the knowledge of locoregional tumor spread, in particular lymph node metastasis. In general, lymphatic spread follows anatomic rules, skipping of nodes is observed maximally in 3%. According to tumor site, uni- or... |
11098571 | [Significance of immunohistochemically detectable tumor cells in lymph nodes]. | Distant metastasis is mainly determined by the tumor biology, whereas local relapse plete (R0) resection of solid tumors is largely determined by the effectiveness of the surgeon. The detection of a minimal tumor cell spread in lymph nodes became recently possible by the introduction of sensitive immunohistochemical an... |
11098572 | [Significance of lymph nodes in tumor surgery. Value of minimally invasive staging]. | Malignant tumors require an exact staging in order to initiate individual tumor related therapeutic concepts to avoid unnecessary explorative laparotomy and pare different treatment regimes. The assessment of the lymph node status with regard to tumor involvement using any of the actual imaging methods is quite unsatis... |
11098573 | [Immunotherapy in malignant melanoma]. | The malignant melanoma is because of its ability to form metastasis even at early stages of disease the deadliest of all skin tumors. Its incidence rises faster than that of any other human tumor. Today, treatment of melanoma is based on surgical removal, and depending on the stage, chemotherapy and/or biological respo... |
11098574 | [Melanoma. Results with "sentinel node" sampling]. | Since June 1995 we have practised a gamma probe guided sentinel lymphadenectomy (SLNE) in 274 patients after injecting a colloidal 99 m-Tc labelled solution around the tumor. By this technique the detection and excision of the SLN succeeded in 99.3% of all cases. We found micrometastases in about 53.1% of patients with... |
11098575 | [Importance of lymph node involvement in breast carcinoma for the oncologist]. | Axillary node status is the most important prognostic information regarding treatment and prognosis for breast cancer patients. Localisation and number of involved lymph nodes add further information and are of prognostic relevance as well. The problem of the involvement of different axilla levels as well as skip metas... |
11098576 | ["Sentinel" lymph node biopsy in breast carcinoma. Current experiences]. | Recent studies show the sentinel lymph node biopsy (SNB) as a reliable method for the determination of the nodal status in patients with breast cancer. We present our experience with this method during 3 years and discuss its potential and limitations. From 11/95 to 3/99 we performed a sentinel node detection in 146 pa... |
11098577 | [Surgical axilla dissection. Technical standard or obsolete method?]. | Axillary lymph node status remains the single most important prognostic parameter and has crucial therapeutic implications in patients with breast carcinoma. Surgical dissection of the axilla monly regarded as the standard procedure of axillary staging, its sensitivity and specificity being 99% and 100%, respectively. ... |
11098578 | [The significance of lymph node status in papillary and follicular thyroid gland carcinoma for the nuclear medicine physician]. | The impact of lymph node metastases on prognosis of differentiated thyroid cancer is discussed controversially. Therefore the data of 596 patients with papillary or follicular thyroid cancer are analysed retrospectively, which have been treated between 1980 and 1995 at the Clinic and Policlinic for Nuclear Medicine of ... |
11098579 | [Pro and contra lymphadenectomy in papillary and follicular thyroid gland carcinoma]. | Patients with papillary and follicular thyroid carcinomas are said to have an excellent long-term prognosis. However, over 90% of papillary carcinomas have synchrone lymph node metastases. Based on clinical, histopathologic and molecular-biological factors, different patient groups can be defined with an increased recu... |
11098580 | [The value of blood transfusion in tumor surgery. Experiences from randomized trials]. | Since the first publication by Tartter in 1982 [3] multiple studies were performed concerning the association between blood transfusion and e in surgical oncology. The hypothesis was that blood transfusion-associated immunosuppression influences postoperative infection rates and long-term prognosis. Due to the fact tha... |
11098581 | [Transfusion use in curatively operated patients with colorectal carcinomas. Swiss Study Group for Clinical Cancer Research]. | Is there an improvement of the behaviour for restrective blood transfusions after the data in the literature and especially the preliminary data of the SAKK 40/81 study have been published? They have shown a worsening of the prognosis in patients with colorectal cancer after pre-/postoperative blood transfusions have b... |
11098582 | [Role of lymph nodes in rectal carcinoma]. | The significance of the lymph nodes for the therapy and the prognostics of the rectal cancer are reviewed. Not only the depth of penetrations, but the probability of lymph node involvement (in our series tumors staged T1 had in 12% positive lymph nodes, T2 in 20% respectively, T3 in 37% and T4 in 80%) determine the pos... |
11098583 | [The role of lymph nodes in colon carcinoma]. | Metastatic spread of colon cancer to intermediate lymph nodes is found, depending on tumor stage, in up to 44% of patients and to central lymph nodes in about 10%. The incidence of skip metastases is estimated not to exceed 5%. Tumorous involvement of pericolic lymph nodes occurs almost only within a 10 cm distance fro... |
11098593 | [Biology and needs of the aged]. | The elderly age group is growing rapidly as a proportion of the total population of Italy. By the year 2020 the population aged 65 and over is expected to increase from 17% to 23%. The biological process of aging leads to a loss of functional reserves, and so elderly people are frail and affected by multiple diseases. ... |
11098594 | [Work capacity and aging]. | Maintaining a good work ability depends on satisfactory health and employment status, which is supported by suitable working conditions and correct life styles. From the biological perspective, ageing means a foreseeable progressive and overall deterioration of the various physiological systems, but not of such a kind ... |
11098598 | [Aging at work and musculoskeletal disorders]. | By means of a critical review of the international literature and of their own published experiences, the Authors discuss the influence of the "age" factor on work related musculoskeletal disorders of the spine and upper limbs. Regarding the spine, the lumbosacral spine in particular, there is evidence (both in relatio... |
11098595 | [Deficiencies and resources of working population in relation to age: a multidisciplinary approach]. | The aging of the population as a whole and the later age at which young people start work are increasing the percentage of older employees. In situations where the working conditions are highly demanding, as in shiftwork, time-pressure jobs, and adaptation to modern technology or skill diversification, this demographic... |
11098600 | [ESTEV study on relationship between health, work and aging in Italy]. | A longitudinal epidemiological study into the relationships between age/health/work is currently under way in different geographical areas throughout Italy. The research is co-ordinated by INRCA (Italian National Research Centres on Aging) in Ancona with the collaboration of the Universities of Ancona, Verona and Bari.... |
11098601 | [Physical exercise in the prevention of musculoskeletal diseases in the elderly worker]. | This paper reviews the impact of ageing on physical work capacity in the elderly worker and the benefits of exercise programmes designed for the prevention of plaints. Physical work capacity generally declines significantly after 50 years of age as a consequence of a reduction in aerobic capacity and muscle strength. T... |
11098596 | [Psychological and psychosocial aspects in the elderly workers]. | The international literature is producing information about job performance of elderly workers that is in contrast with current prejudice. Objectively, the elderly worker exhibits changes in performance but these changes do not necessarily interfere in a negative way. On the contrary, they sometimes have an extremely p... |
11098609 | [Incidental findings in gastroenterology. Preventing overdiagnosis]. | The use of diagnostic imaging procedures and laboratory investigations in gastroenterology can sometimes lead to findings of questionable value. This highlights the problem--also from the point of view of costs--of deciding whether further diagnostic investigation is necessary or not. No requirement for action is given... |
11098597 | [Occupational aging and cardiovascular diseases]. | A short review of occupational aging and cardiovascular disease is presented. Coronary and stroke events are typical diseases of aging, in which rare monogenic disorders mon polymorphisms interact with environmental factors. Among these factors, particular attention has been given to social and occupational organizatio... |
11098610 | [Incidental findings in cardiology. Diagnosing today what can cause illness tomorrow]. | Among the anatomical and functional findings in cardiology, congenitally corrected transposition of the major vessels (ventricular inversion), bicuspid aortic valve and prolapse of the mitral valve with simultaneous mitral insufficiency have at least a potential for causing future problems. In such cases, regular cardi... |
11098599 | [Fatiguing work, aging and health: a cross-sectional study of a group of anesthesiologists]. | A cross-sectional study was carried out to verify if work as an anaesthetician-reanimator can be considered as a fatiguing job. An anonymous self-administered questionnaire was utilized to obtain information about the general characteristics of the subjects, job organization, human relations, perceived risks and previo... |
11098602 | [Aging and work: health aspects in cleaners]. | Over the last few years, studies on the relationship between ageing and work have attracted growing interest due to the increased probability among workers of developing major health problems as a consequence of ageing workers. Negative es for health are possible when an age-related imbalance appears between physical w... |
11098603 | [Aging and occupational accidents]. | Ageing and occupational accidents is an underestimated issue in Italy. This deals both with ings of data and proper studies in the matter and with safety culture and interventions. Nevertheless, some tables are presented showing a relation between ageing and occupational accidents both in frequency and in severity. The... |
11098611 | [Incidental findings in endocrinology. When to observe and when intervention is necessary]. | Hirsutism, astia or delayed puberty are usually benign conditions. However, underlying serious disorders must be excluded. Abnormalities in thyroid hormone measurements with contraceptives, glucocorticoids or severe nonthyroid disease must be differentiated from "true" impairments of thyroid function that require speci... |
11098618 | [Epidemiology, clinic and treatment of dermatomycoses caused by zoophilic dermatophytes] . | In the last 50 years the spectrum of agents of dermatophytoses changed. The change is remarkable especially in the case of zoophilic dermatophytes. Microsporum canis has displaced Trichophyton verrucosum. In the period from 1966 to 1970 2822 dermatophytoses were registered as occupational dermatoses in the former Germa... |
11098619 | [Incidence and control of cattle ringworm in Scandinavia]. | Clinical aspects, prophylactic as well as therapeutical vaccination with a live attenuated vaccine against Trichophyton verrucosum are dealt with in this article. Further, the epidemical and zoonotical view of the disease is described. The farmers' motives to vaccinate differ depending on type of herd. Hygienic and dis... |
11098620 | [Molecular biological methods and their consequences in taxonomy and diagnosis of dermatophytes]. | Trichophyton rubrum, T. mentagrophytes, T. verrucosum, Microsporum canis, M. gypseum and Epidermophyton flocoosum represent the cause of human dermatomycoses isolated most often at the University Hospital of Dermatology in Graz, Austria, between 1991 and 1998. So far, identification was mainly based on the cultivation ... |
11098621 | [Differentiation of yeasts in mastitis milk] . | Differentiating 174 yeasts from clinical samples to get a survey of those species found in mastitis milk and milking machines we identified five genera with 29 species. Species of the genus Candida dominated with 77% of all samples. More than 25% of yeasts from milk were identified as C. rugosa and more than 20% as C. ... |
11098622 | [Mycozoonoses with special regard to ringworm of cattle]. | Ringworm of cattle is nearly exclusively caused by Trichophyton verrucosum. This skin disease is worldwide present in cattle and is responsible for high economic losses in cattle farming. T. verrucosum may also be responsible for severe skin diseases in man. For economic and epidemiological causes a control of ringworm... |
11098623 | [Evidence of Cryptococcus neoformans in domestic and sports pigeons in Thyringia]. | 19 strains of Cryptococcus neoformans var. neoformans were isolated from 17 (= 40.5%) of 42 investigated pigeon breeder flocks in Thuringia. |
11098624 | [Asteroid bodies: host-pathogen reactions in mycoses]. | A review of the literature on asteroid bodies (Splendore-Hoeppli phenomenon) as well as an immunoelectronmicroscopic study on asteroid bodies with Candida albicans and electronmicroscopic observations on asteroid bodies with Aspergillus are presented. The following definitions are proposed: Asteroid bodies with Candida... |
11098625 | [Host-pathogen relations in yeasts]. | Allogenic and autogenic factors are decisive for a colonization of warmblooded hosts by yeasts where they can live inside as mensal or pathogen. To develop pathogenicity a capacity of yeasts for multiplication inside of humans or homoiothermic animals and resistance to environmental influences is not sufficient. Pathog... |
11098626 | [Molecular biological differentiation of yeasts]. | Regarding the rise and the epidemiological shifts in Candida infections, accurate and rapid identification of yeasts to species level is exceedingly important. Furthermore, non-albicans species (e.g. C. glabrata, C. dubliniensis, C. inconspicua, C. krusei and C. norvegensis) have recently emerged as azole-resistant pat... |
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