entities list | text stringlengths 10 3.62k | split stringclasses 3
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|---|---|---|
[
"VU0360172",
"polyphosphoinositide",
"MTEP",
"Glutamate"
] | Absence epilepsy is generated by the cortico-thalamo-cortical network, which undergoes a finely tuned regulation by metabotropic glutamate (mGlu) receptors. We have shown previously that potentiation of mGlu1 receptors reduces spontaneous occurring spike and wave discharges (SWDs) in the WAG/Rij rat model of absence ep... | train |
[
"corticosterone"
] | Neonatal exposure to low dose corticosterone persistently modulates hippocampal mineralocorticoid receptor expression and improves locomotor/exploratory behaviour in a mouse model of Rett syndrome. | train |
[
"CORT",
"corticosterone"
] | Rett syndrome (RTT) is a pervasive neurodevelopmental disorder, primarily affecting girls. RTT causes a wide variety of debilitating symptoms and no cure currently exists. Mouse models bearing mutations in the Mecp2 gene recapitulate most physiological and behavioural RTT-related abnormalities. Stimulating neonatal env... | train |
[
"phenoxazine"
] | Isolation, characterisation and biological evaluation of a phenoxazine, a natural dyestuff isolated from leaves of Peristrophe bivalvis. | train |
[
"peristrophine"
] | Peristrophe bivalvis (L.) Merr. (Acanthaceae) is a wild growing and cultivated plant used for dyeing of foods by the ethnic minorities of Vietnam. The major component of the colour aqueous extract (CAE) of its leaves was identified as peristrophine by spectral analysis, especially the 2D NMR spectra (HSQC, HMBC and NOE... | train |
[] | Bearberry identification by a multidisciplinary study on commercial raw materials. | train |
[
"arbutin"
] | Herbal species different from the official bearberry, Arctostaphylos uva-ursi, are sold through conventional markets and also through non-controlled Internet websites, putting consumer safety at risk owing to the lack of quality control. Recently, Arctostaphylos pungens has become one of the most used species as a raw ... | train |
[] | Lipid biomarkers of oxidative stress in a genetic mouse model of Smith-Lemli-Opitz syndrome. | train |
[
"oxysterols",
"3β-hydroxysterol",
"isoprostanes",
"oxysterol",
"DHCEO",
"7-Dehydrocholesterol",
"IsoPs",
"arachidonic acid",
"neuroprostanes",
"docosahexaenoic acid",
"3β,5α-dihydroxycholest-7-en-6-one",
"NeuroPs",
"7-DHC"
] | 7-Dehydrocholesterol (7-DHC) accumulates in tissues and fluids of patients with Smith-Lemli-Opitz syndrome (SLOS), which is caused by mutations in the gene encoding 3β-hydroxysterol-Δ(7)-reductase (DHCR7). We recently reported that 7-DHC is the most reactive lipid molecule toward free radical oxidation (lipid peroxidat... | train |
[] | Cytotoxic constituents from the fungus Daldinia concentrica (Xylariaceae). | train |
[
"isocoumarin",
"6,8-dihydroxy-3-methyl-3,4-dihydroisocoumarin",
"ergosterol",
"methanol",
"(22R)-hydroxylanosta-7,9(11),24-trien-3-one"
] | Phytochemical study on the methanol extract of the fruit bodies of Vietnamese fungus Daldinia concentrica has led to the isolation and structural elucidation of three cytotoxic constituents, 6,8-dihydroxy-3-methyl-3,4-dihydroisocoumarin (1), (22R)-hydroxylanosta-7,9(11),24-trien-3-one (2) and ergosterol (3). Their stru... | train |
[] | Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency. | train |
[
"resorcinol",
"pPD",
"DNCB",
"lactic acid"
] | At present, the identification of potentially sensitizing chemicals is carried out using animal models. However, it is very important from ethical, safety and economic point of view to have biological markers to discriminate allergy and irritation events, and to be able to classify sensitizers according to their potenc... | train |
[
"D-Serine",
"cocaine"
] | D-Serine facilitates the effectiveness of extinction to reduce drug-primed reinstatement of cocaine-induced conditioned place preference. | train |
[
"cocaine",
"D-serine"
] | Addiction is a disease that is characterized by compulsive drug-seeking and use despite negative health and social consequences. One obstacle in treating addiction is a high susceptibility for relapse which persists despite prolonged periods of abstinence. Relapse can be triggered by drug predictive stimuli such as env... | train |
[] | What should we do about student use of cognitive enhancers? An analysis of current evidence. | train |
[] | This article reviews current data on the use of cognition enhancers as study aids in the student population. It identifies gaps and uncertainties in the knowledge required to make a balanced assessment of the need for some form of regulation. The review highlights the weak evidence on the prevalence of use of such drug... | train |
[] | Hippocampal long-term depression mediates spatial reversal learning in the Morris water maze. | train |
[
"AMPA",
"Ro25-6981"
] | Synaptic plasticity at hippocampal excitatory synapses has been proposed as the cellular mechanism underlying spatial learning and memory. However, most previous studies have focused on the role of long-term potentiation (LTP) in learning and memory, and much less is known about the role of long-term depression (LTD). ... | train |
[] | The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression. | train |
[] | The tumour suppressor p53, involved in DNA repair, cell cycle arrest and apoptosis, also inhibits blood vessel formation, that is, angiogenesis, a process strongly contributing to tumour development. The p53 gene expresses 12 different proteins (isoforms), including TAp53 (p53 (or p53α), p53β and p53γ) and Δ133p53 isof... | train |
[] | The Hedgehog processing pathway is required for NSCLC growth and survival. | train |
[] | Considerable interest has been generated from the results of recent clinical trials using smoothened (SMO) antagonists to inhibit the growth of hedgehog (HH) signaling-dependent tumors. This interest is tempered by the discovery of SMO mutations mediating resistance, underscoring the rationale for developing therapeuti... | train |
[
"20(S)-Protopanaxatriol",
"ppt"
] | The Inhibitory Effect of 20(S)-Protopanaxatriol (ppt) Towards UGT1A1 and UGT2B7. | train |
[
"UDP",
"20(S)-protopanaxatriol",
"ppt",
"ginsenosides"
] | Ginseng, a commonly used natural product, has been frequently reported to induce herb-drug interaction with many clinical drugs. The intestinal bacterial metabolites of ginsenosides have been widely regarded as the substance basis for ginseng-drug interactions. To date, little is known about the inhibitory effect of in... | train |
[] | A pathogenetic link between non-alcoholic fatty liver disease and celiac disease. | train |
[] | Non-alcoholic fatty liver disease (NAFLD) has recently been recognized as the leading cause of the abnormalities in the liver function tests in the Western countries. Celiac disease (CD) is a permanent immunological intolerance to gluten proteins in genetically predisposed individuals. CD has been reported in 4-13 % of... | train |
[
"glutamate"
] | Role of metabotropic glutamate receptors in persistent forms of hippocampal plasticity and learning. | train |
[
"Glutamate",
"glutamate"
] | Storage and processing of information at the synaptic level is enabled by the ability of synapses to persistently alter their efficacy. This phenomenon, known as synaptic plasticity, is believed to underlie multiple forms of long-term memory in the mammalian brain. It has become apparent that the metabotropic glutamate... | train |
[
"sulpiride"
] | The response to sulpiride in social anxiety disorder: D2 receptor function. | train |
[
"Sulpiride",
"sulpiride"
] | Some previous studies have suggested that patients with social anxiety disorder (SAD) have a hypoactive central dopaminergic system. Supporting this there have been reports from neuroimaging studies of reduced striatal D2 receptor binding in subjects with SAD. The aim of this study was to investigate D2 receptor sensit... | train |
[] | AMPK signalling and the control of substrate use in the heart. | train |
[
"ATP",
"serine",
"glucose",
"fatty acid",
"adenosine triphosphate",
"threonine",
"adenosine monophosphate"
] | All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply of substrates to match... | train |
[
"mirtazapine"
] | Predictors and mediators of add-on mirtazapine-induced cognitive enhancement in schizophrenia--a path model investigation. | train |
[
"mirtazapine",
"Mirtazapine"
] | We aimed to evaluate predictors and mediators of enhancing effect of adjunctive mirtazapine on cognition in schizophrenia. Patients with difficult-to-treat schizophrenia received either mirtazapine (n = 19) or placebo (n = 18) in a double-blind fashion for six weeks. Mirtazapine outperformed placebo on the Block Design... | train |
[
"cisplatin"
] | Dietary flaxseed oil supplementation ameliorates the effect of cisplatin on brush border membrane enzymes and antioxidant system in rat intestine. | train |
[
"cis-diamminedichloroplatinum II",
"Cisplatin",
"ω-3 polyunsaturated fatty acid",
"glutathione",
"sulfhydryl"
] | Cisplatin (CP; cis-diamminedichloroplatinum II) is a drug widely used against different types of solid tumors. Patients receiving CP, however, experience very profound and long lasting gastrointestinal symptoms. Recently, ω-3 polyunsaturated fatty acid-enriched flaxseed/flaxseed oil (FXO) has shown numerous health bene... | train |
[
"lanthanide"
] | Anion binding in water at lanthanide centres: from structure and selectivity to signalling and sensing. | train |
[
"lanthanide",
"lactate",
"urate",
"bicarbonate",
"citrate"
] | Reversible anion binding at lanthanide centres in aqueous media has emerged as an effective means of signalling and sensing the presence of selected anions. The constitution and configuration of a wide range of anion adducts has been defined by X-ray analyses and NMR methods, and both chelating and monodentate binding ... | train |
[
"Flavonoid"
] | Flavonoid constituents and biological screening of Astragalus bombycinus Boiss. | train |
[
"5,2',4'-trihydroxy-flavone-8-C-α-arabinopyranoside-7-O-β-glucopyranoside",
"apigenin 7-O-gentobioside",
"luteolin-7-O-β-glucopyranoside",
"daidzein",
"quercetin-3,7-di-O-β-glucopyranoside",
"quercetin-3,7-di-O-β-glucopyranoside 4'-O-α-rhamnopyranoside",
"luteolin",
"flavonoid",
"quercetin-3-O-β-glu... | Two new flavonoid compounds were isolated from Astragalus bombycinus Boiss. and identified as quercetin-3,7-di-O-β-glucopyranoside 4'-O-α-rhamnopyranoside and 5,2',4'-trihydroxy-flavone-8-C-α-arabinopyranoside-7-O-β-glucopyranoside. In addition, apigenin, apigenin-7-O-β-glucopyranoside, apigenin 7-O-gentobioside, luteo... | train |
[] | Bioactive alkaloids produced by Pseudomonas brassicacearum subsp. Neoaurantiaca, an endophytic bacterium from Salvia miltiorrhiza. | train |
[
"cyclodipeptides",
"cyclo-(L-Tyr-trans-4-hydroxy-L-Pro)",
"cyclo-(L-Pro-Gly)",
"cyclo-(L-Ala-L-Ala)",
"cyclo-(L-Pro-L-Ser)",
"3-methylhydantoin",
"2-piperidinone",
"cyclo-(L-Ala-trans-4-hydroxy-L-Pro)",
"cyclo-(Gly-L-Ala)",
"cyclo-(L-Ala-L-Tyr)",
"yclo-(L-Val-L-Pro)",
"cyclo-(Gly-L-Tyr)"
] | Eleven compounds were isolated from the culture of an endophytic bacterium Pseudomonas brassicacearum subsp. Neoaurantiaca in Salvia miltiorrhiza Bunge. Their structures were elucidated by spectroscopic methods as cyclo-(Gly-L-Ala) (1), cyclo-(L-Ala-L-Ala) (2), cyclo-(L-Pro-Gly) (3), cyclo-(L-Pro-L-Ser) (4), cyclo-(L-A... | train |
[
"terephthalic acid",
"iodide"
] | Correlation between iodide dosimetry and terephthalic acid dosimetry to evaluate the reactive radical production due to the acoustic cavitation activity. | train |
[
"terephthalic acid",
"iodide",
"KI"
] | Acoustic cavitation plays an important role in sonochemical processes and the rate of sonochemical reaction is influenced by sonication parameters. There are several methods to evaluate cavitation activity such as chemical dosimetry. In this study, to comparison between iodide dosimetry and terephthalic acid dosimetry,... | train |
[
"modafinil"
] | Association of a deficit of arousal with fatigue in multiple sclerosis: effect of modafinil. | train |
[
"Modafinil",
"modafinil"
] | Multiple sclerosis (MS) is a multifocal demyelinating disease of the central nervous system, leading to chronic disability. Fatigue is a common and distressing symptom of MS which is unrelated to its clinical form, stage of development, the degree of disability, or the lesion load on magnetic resonance imaging. Fatigue... | train |
[] | Postsynaptic mGluR mediated excitation of neurons in midbrain periaqueductal grey. | train |
[
"Glutamate",
"CNQX",
"CPCCOEt",
"DHPG",
"AP5",
"glutamate",
"antagonist MPEP",
"TBOA",
"MPEP"
] | Metabotropic glutamate (mGlu) receptors modulate pain from within the midbrain periaqueductal grey (PAG). In the present study, the postsynaptic mGlu receptor mediated effects on rat PAG neurons were examined using whole-cell patch-clamp recordings in brain slices. The selective group I agonist DHPG (10 μM) produced an... | train |
[
"glucose"
] | GLP-1 receptor activated insulin secretion from pancreatic β-cells: mechanism and glucose dependence. | train |
[
"glucose"
] | The major goal in the treatment of type 2 diabetes mellitus is to control the hyperglycaemia characteristic of the disease. However, treatment with common therapies such as insulin or insulinotrophic sulphonylureas (SU), while effective in reducing hyperglycaemia, may impose a greater risk of hypoglycaemia, as neither ... | train |
[] | New long-chain aliphatic compounds from Peperomia dindygulensis. | train |
[
"acylresorcinol",
"dindyguleranone",
"octaketide",
"dindygulerione C",
"(+)-2-heptadecyl-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one",
"2-(1,3-dihydroxyphenyl)-octacosan-1'-one",
"polyketide",
"(-)-(4S)-2-[(Z)-1'-(6″,7″-dihydroxyphenethyl-amino)octadec-11'-enylidene]-4-hydroxycyclohexane-1,3-dio... | Three long-chain aliphatic compounds, including one new polyketide derivative, dindygulerione C (1), one new octaketide derivative, dindygulerione D (2) and one new acylresorcinol derivative dindyguleranone (3) were isolated from the whole plant of the Chinese anticancer folk medicine Peperomia dindygulensis Miq. (Pipe... | train |
[
"hydroxyapatite",
"carbon"
] | Hydrothermally mixed hydroxyapatite-multiwall carbon nanotubes composite coatings on biomedical alloys by electrophoretic deposition. | train |
[
"n-butanol",
"H(3)PO(4)",
"carbon",
"Hydroxyapatite",
"Ca (CH(3)COO)(2)",
"Ti",
"Calcium acetate",
"phosphoric acid"
] | Hydroxyapatite (HA) coatings have been used to improve biological and mechanical fixation of metallic prosthesis. Because of extraordinary features of carbon nanotubes (CNTs), they have a lot of facilities, such as extremely strong nanoreinforcement materials for composites. HA powders were synthesized and mixed with m... | train |
[] | Quality assessment and scavenging activity of Siamese neem flower extract. | train |
[
"flavonoids",
"rutin",
"quercetin"
] | Young leaves and flowers of Siamese neem tree (Azadirachta indica A. Juss. var. siamensis Valeton) are commonly consumed as a bitter tonic vegetable. Active antioxidant components in the flowers are rutin and quercetin flavonoids. The aqueous extracts of young flowers collected from 14 different locations in Thailand w... | train |
[
"Polyphenol"
] | Polyphenol distribution in plant organs of tomato introgression lines. | train |
[
"polyphenols",
"polyphenol",
"CaA",
"rutin",
"chlorogenic",
"ferulic acids",
"caffeic"
] | The content of total polyphenols, chlorogenic, caffeic (CaA) and ferulic acids, and rutin, was investigated in plant organs of three introgression lines (IL7-3, IL10-1 and IL12-4) of Solanum pennellii in Solanum lycopersicum cv M82 and compared with that of cropped parental. Such study aims to evidence factors associat... | train |
[] | The potential impact of strawberry on human health. | train |
[
"vitamin C",
"phenolic",
"folate"
] | The strawberry (Fragaria X ananassa, Duch.) represents a relevant source of micronutrients, such as minerals, vitamin C, folate and phenolic substances, most of which are natural antioxidants and contribute to the high nutritional quality of the fruit. All these compounds are essential for health and, in particular, st... | train |
[
"parabens"
] | Urinary excretion of parabens in pregnant Japanese women. | train |
[
"parabens",
"methyl, ethyl, n-propyl and n-butyl parabens",
"p-hydroxybenzoic acid"
] | Urinary excretion of free and total (free plus conjugated) forms of methyl, ethyl, n-propyl and n-butyl parabens (MP, EP, PP and BP, respectively) and their metabolite p-hydroxybenzoic acid were measured for 111 pregnant Japanese women. Frequent detection of parabens and their metabolite indicated that exposure takes p... | train |
[] | The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women. | train |
[] | To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, ... | train |
[
"Flavonoids"
] | Flavonoids and antioxidant activity of flowers of Mexican Crataegus spp. | train |
[
"quercetin 3-O-glucoside",
"quercetin 3-O-rhamnosyl-(1 → 2)-[rhamnosyl-(1 → 6)]-glucoside",
"quercetin 3-O-rhamnoside",
"flavonoids",
"Flavonoid",
"quercetin 3-O-rhamnosyl-(1 → 6)-glucoside",
"Flavonoids"
] | Flavonoids and antioxidant activity of extracts of flowers from some Mexican accessions of Crataegus were studied using six accessions with the purpose of contributing to the knowledge of the nutraceutical properties of the accessions of the Germplasm Bank of the Universidad Autonoma Chapingo. Flavonoids were identifie... | train |
[] | Antioxidant activity of Buglossoides purpureocaerulea (L.) I.M. Johnst. extracts. | train |
[
"lithospermic acid",
"DPPH",
"salvianolic acid C",
"ferric",
"methanol",
"caffeic acid",
"Trolox",
"ethanol",
"rosmarinic acid"
] | Buglossoides purpureocaerulea is a little-known plant used in the folk tradition for the preparation of a decoction in Sud, Italy, where it is appreciated for its beneficial effects on liver diseases. These properties may be due to the presence of antioxidant compounds. This study presents the phenolic characterisation... | train |
[
"progesterone"
] | Live-birth rates after HP-hMG stimulation in the long GnRH agonist protocol: association with mid-follicular hCG and progesterone concentrations, but not with LH concentrations. | train |
[
"progesterone",
"estradiol"
] | The aim of this retrospective study was to investigate the impact of endogenous and exogenous luteinizing hormone (LH) activity on treatment outcome, when taking into consideration potential confounding variables. Data were derived from IVF patients (n = 358) stimulated with highly purified menotrophin (HP-hMG) in a lo... | train |
[
"PEI",
"Li"
] | Development and characterization of composite YSZ-PEI electrophoretically deposited membrane for Li-ion battery. | train |
[
"LiFePO(4)",
"LiPF(6)",
"Li",
"polyethyleneimine"
] | In this work, the electrophoretic-deposition (EPD) method was used to fabricate pristine and composite ceramic-polymer membranes for application in planar and 3D microbattery configurations. The major focus was on the effect of polyethyleneimine additive on the morphology, composition, and electrochemical properties of... | train |
[
"monophthalates"
] | Dose response analysis of monophthalates in the murine embryonic stem cell test assessed by cardiomyocyte differentiation and gene expression. | train |
[
"phthalate monoester",
"phthalate monoesters",
"MEHP",
"monobutyl phthalate",
"mono-(2-ethylhexyl) phthalate",
"MMP",
"monobenzyl phthalate",
"MBzP",
"MBuP",
"monomethyl phthalate"
] | The embryonic stem cell test (EST) is based on compound-induced inhibition of cardiomyocyte differentiation of pluripotent stem cells. We examined the use of transcriptomics to assess concentration-effect relationships and performed potency ranking within a chemical class. Three embryotoxic phthalate monoesters, monobu... | train |
[] | The antioxidant and anticancer effects of wild carrot oil extract. | train |
[
"DPPH",
"FeSO4",
"trypan blue",
"ferric",
"acetone",
"methanol",
"1,1-diphenyl-2-picryl hydrazyl",
"ferrous"
] | Daucus carota L. ssp. carota (Apiacea) is used in traditional medicine in Lebanon and in different regions throughout the world. The present study investigates the in vitro anticancer activities of Daucus carota oil extract (DCOE) on four human cancer cell lines as well as its in vitro antioxidant activity. DCOE was ex... | train |
[
"Saponin"
] | Protective Effects of a Purified Saponin Mixture from Astragalus corniculatus Bieb., in vivo Hepatotoxicity Models. | train |
[] | Influence of low ultrasound intensity on the degradation of dextran catalyzed by dextranase. | train |
[
"tryptophan"
] | In our current research work, the effect of ultrasound irradiation on the enzymatic activity and enzymatic hydrolysis kinetic parameters of dextran catalysis by dextranase were investigated. Furthermore, the effects of ultrasound irradiation on the structure of dextranase were investigated with the aid of fluorescence ... | train |
[
"Atomoxetine"
] | Atomoxetine modulates spontaneous and sensory-evoked discharge of locus coeruleus noradrenergic neurons. | train |
[
"isoflurane",
"Atomoxetine",
"ATM",
"norepinephrine"
] | Atomoxetine (ATM) is a potent norepinephrine (NE) uptake inhibitor and increases both NE and dopamine synaptic levels in prefrontal cortex, where it is thought to exert its beneficial effects on attention and impulsivity. At the behavioral level, ATM has been shown to cause improvements on the measures of executive fun... | train |
[
"fluoxetine"
] | Could maternal exposure to the antidepressants fluoxetine and St. John's Wort induce long-term reproductive effects on male rats? | train |
[
"FLX",
"fluoxetine"
] | Based on the limited number of studies that have investigated the adverse effects of maternal treatment with antidepressants on the development of male descendents, this study was carried out in rat in order to evaluate if maternal exposure to fluoxetine (FLX) or St. John's Wort (SJW) could disrupt the development of m... | train |
[] | Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke. | train |
[
"cadmium"
] | Embryonic stem cells (ESCs) provide a valuable in vitro model for testing toxicity of chemicals and environmental contaminants including cigarette smoke. Mouse ESCs were acutely or chronically exposed to smoke components, cigarette smoke condensate (CSC), or cadmium, an abundant component of CSC, and then evaluated for... | train |
[
"C60",
"thiophene"
] | Electrophoretic deposition of the thiophene-based copolymer and its composites with C60. | train |
[
"C(60)",
"toluene",
"poly(3-octylthiophene-2,5-diyl-co-3-decyloxythiophene-2,5-diyl)",
"acetonitrile",
"POT-co-DOT",
"thiophene"
] | Electrophoretic deposition is a useful and efficient technique to deposit conjugated polymers, if suitable suspension of the target polymer is obtained. Unfortunately, neither general theory nor universal procedure for the preparation of a suspension suitable for electrophoretic deposition has seemed to be established ... | train |
[
"oximes"
] | Structural requirements for effective oximes - Evaluation of kinetic in vitro data with phosphylated human AChE and structurally different oximes. | train |
[
"organophosphorus",
"bispyridinium oximes",
"oximes",
"oxime"
] | Treatment of poisoning by various organophosphorus (OP) nerve agents with established acetylcholinesterase (AChE) reactivators (oximes) is insufficient. In consequence, extensive research programs have been undertaken in various countries in the past decades to identify more effective oximes. The efficacy of new compou... | train |
[] | Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips. | train |
[
"hydroxy-omeprazole",
"tolbutamide",
"midazolam",
"dextromethorphan",
"paraxanthine",
"1-OH-midazolam",
"acetaminophen",
"dextrorphan",
"omeprazole sulfone",
"repaglinide",
"hydroxyl-repaglinide",
"omeprazole",
"dextromethorpahn",
"Fluorescein diacetate",
"caffeine"
] | We present characterization of the metabolic performance of human cryopreserved hepatocytes cultivated in a platform of parallelized microfluidic biochips. The RTqPCR analysis revealed that the mRNA levels of the cytochromes P450 (CYP 1A2, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, 3A4) were reduced after the adhesion period (when... | train |
[
"Vitamin A",
"retinoic acid"
] | Vitamin A deficiency disturbs collagen IV and laminin composition and decreases matrix metalloproteinase concentrations in rat lung. Partial reversibility by retinoic acid. | train |
[
"all-trans-retinoic acid",
"Vitamin A",
"vitamin A",
"retinol",
"retinoids",
"retinoic acid",
"vitamin-A"
] | Vitamin A is essential for lung development and pulmonary cell differentiation. Its deficiency leads to altered lung structure and function and to basement membrane architecture and composition disturbances. Previously, we showed that lack of retinoids thickens the alveolar basement membrane and increases collagen IV, ... | train |
[
"barium ferrite"
] | The alignment of barium ferrite nanoparticles from their suspensions in electric and magnetic fields. | train |
[
"dodecylbenzenesulphonic acid",
"1-butanol",
"barium ferrite"
] | The alignment of plate-like barium ferrite nanoparticles, with diameters of 10-350 nm and thicknesses of 3-10 nm, in electric and/or magnetic fields was studied. Stable suspensions were prepared in 1-butanol with dodecylbenzenesulphonic acid as a surfactant. The deposits were produced from the suspensions with classic ... | train |
[] | Sclerostin antibody improves skeletal parameters in a Brtl/+ mouse model of osteogenesis imperfecta. | train |
[
"Gly",
"Cys"
] | Osteogenesis imperfecta (OI) is a genetic bone dysplasia characterized by osteopenia and easy susceptibility to fracture. Symptoms are most prominent during childhood. Although antiresorptive bisphosphonates have been widely used to treat pediatric OI, controlled trials show improved vertebral parameters but equivocal ... | train |
[] | Hospitalized osteoporotic vertebral fracture increases the risk of stroke: a population-based cohort study. | train |
[
"aspirin",
"nitrates"
] | The association between osteoporosis and cardiovascular diseases has been demonstrated. Higher cardiovascular risk has also been correlated with vertebral fractures. However, the association between osteoporotic vertebral fracture and the possibly higher risk of stroke remains uncertain. This study aimed to evaluate th... | train |
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