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Vaccines rely on immune modulation or augmentation. Vaccination either excites or reinforces the immune competence of a host to ward off infection, leading to the activation of macrophages, the production of antibodies, inflammation, and other classic immune reactions. Antibacterial vaccines have been responsible for a...
Phage therapy is another option that is being looked into for treating resistant strains of bacteria. The way that researchers are doing this is by infecting pathogenic bacteria with their own viruses, more specifically, bacteriophages. Bacteriophages, also known simply as phages, are precisely bacterial viruses that i...
In April 2013, the Infectious Disease Society of America (IDSA) reported that the weak antibiotic pipeline does not match bacteria's increasing ability to develop resistance. Since 2009, only 2 new antibiotics were approved in the United States. The number of new antibiotics approved for marketing per year declines con...
Possible improvements include clarification of clinical trial regulations by FDA. Furthermore, appropriate economic incentives could persuade pharmaceutical companies to invest in this endeavor. Antibiotic Development to Advance Patient Treatment (ADAPT) Act aims to fast track the drug development to combat the growing...
Windows 8 introduced major changes to the operating system's platform and user interface to improve its user experience on tablets, where Windows was now competing with mobile operating systems, including Android and iOS. In particular, these changes included a touch-optimized Windows shell based on Microsoft's "Metro"...
Windows 8 was released to a mixed critical reception. Although reaction towards its performance improvements, security enhancements, and improved support for touchscreen devices was positive, the new user interface of the operating system was widely criticized for being potentially confusing and difficult to learn (esp...
Windows 8 development started before Windows 7 had shipped in 2009. At the Consumer Electronics Show in January 2011, it was announced that the next version of Windows would add support for ARM system-on-chips alongside the existing x86 processors produced by vendors, especially AMD and Intel. Windows division presiden...
Three milestone releases of Windows 8 leaked to the general public. Milestone 1, Build 7850, was leaked on April 12, 2011. It was the first build where the text of a window was written centered instead of aligned to the left. It was also probably the first appearance of the Metro-style font, and its wallpaper had the t...
The build was released for download later in the day in standard 32-bit and 64-bit versions, plus a special 64-bit version which included SDKs and developer tools (Visual Studio Express and Expression Blend) for developing Metro-style apps. The Windows Store was announced during the presentation, but was not available ...
On February 29, 2012, Microsoft released Windows 8 Consumer Preview, the beta version of Windows 8, build 8250. Alongside other changes, the build removed the Start button from the taskbar for the first time since its debut on Windows 95; according to Windows manager Chaitanya Sareen, the Start button was removed to re...
Many other builds were released until the Japan's Developers Day conference, when Steven Sinofsky announced that Windows 8 Release Preview (build 8400) would be released during the first week of June. On May 28, 2012, Windows 8 Release Preview (Standard Simplified Chinese x64 edition, not China-specific version, build ...
On August 1, 2012, Windows 8 (build 9200) was released to manufacturing with the build number 6.2.9200.16384 . Microsoft planned to hold a launch event on October 25, 2012 and release Windows 8 for general availability on the next day. However, only a day after its release to manufacturing, a copy of the final version ...
Relatively few changes were made from the Release Preview to the final version; these included updated versions of its pre-loaded apps, the renaming of Windows Explorer to File Explorer, the replacement of the Aero Glass theme from Windows Vista and 7 with a new flat and solid-colored theme, and the addition of new bac...
Microsoft began an advertising campaign centered around Windows 8 and its Surface tablet in October 2012, starting with its first television advertisement premiering on October 14, 2012. Microsoft's advertising budget of US$1.5–1.8 billion was significantly larger than the US$200 million campaign used to promote Window...
In May 2013, Microsoft launched a new television campaign for Windows 8 illustrating the capabilities and pricing of Windows 8 tablets in comparison to the iPad, which featured the voice of Siri remarking on the iPad's limitations in a parody of Apple's "Get a Mac" advertisements. On June 12, 2013 during game 1 of the ...
New features and functionality in Windows 8 include a faster startup through UEFI integration and the new "Hybrid Boot" mode (which hibernates the Windows kernel on shutdown to speed up the subsequent boot), a new lock screen with a clock and notifications, and the ability for enterprise users to create live USB versio...
Windows Explorer, which has been renamed File Explorer, now includes a ribbon in place of the command bar. File operation dialog boxes have been updated to provide more detailed statistics, the ability to pause file transfers, and improvements in the ability to manage conflicts when copying files. A new "File History" ...
Task Manager has been redesigned, including a new processes tab with the option to display fewer or more details of running applications and background processes, a heat map using different colors indicating the level of resource usage, network and disk counters, grouping by process type (e.g. applications, background ...
New security features in Windows 8 include two new authentication methods tailored towards touchscreens (PINs and picture passwords), the addition of antivirus capabilities to Windows Defender (bringing it in parity with Microsoft Security Essentials). SmartScreen filtering integrated into Windows, Family Safety offers...
Windows 8 supports a feature of the UEFI specification known as "Secure boot", which uses a public-key infrastructure to verify the integrity of the operating system and prevent unauthorized programs such as bootkits from infecting the device's boot process. Some pre-built devices may be described as "certified" by Mic...
Windows 8 provides heavier integration with online services from Microsoft and others. A user can now log in to Windows with a Microsoft account, which can be used to access services and synchronize applications and settings between devices. Windows 8 also ships with a client app for Microsoft's SkyDrive cloud storage ...
Internet Explorer 10 is included as both a desktop program and a touch-optimized app, and includes increased support for HTML5, CSS3, and hardware acceleration. The Internet Explorer app does not support plugins or ActiveX components, but includes a version of Adobe Flash Player that is optimized for touch and low powe...
Windows 8 also incorporates improved support for mobile broadband; the operating system can now detect the insertion of a SIM card and automatically configure connection settings (including APNs and carrier branding), and reduce its internet usage in order to conserve bandwidth on metered networks. Windows 8 also adds ...
Windows 8 introduces a new style of application, Windows Store apps. According to Microsoft developer Jensen Harris, these apps are to be optimized for touchscreen environments and are more specialized than current desktop applications. Apps can run either in a full-screen mode, or be snapped to the side of a screen. A...
Windows Store apps run within a new set of APIs known as Windows Runtime, which supports programming languages such as C, C++, Visual Basic .NET, C#, along with HTML5 and JavaScript. If written in some "high-level" languages, apps written for Windows Runtime can be compatible with both Intel and ARM versions of Windows...
Retail versions of Windows 8 are only able to install these apps through Windows Store—a namesake distribution platform which offers both apps, and listings for desktop programs certified for comparability with Windows 8. A method to sideload apps from outside Windows Store is available to devices running Windows 8 Ent...
The term "Immersive app" had been used internally by Microsoft developers to refer to the apps prior to the first official presentation of Windows 8, after which they were referred to as "Metro-style apps" in reference to the Metro design language. The term was phased out in August 2012; a Microsoft spokesperson denied...
Exceptions to the restrictions faced by Windows Store apps are given to web browsers. The user's default browser can distribute a Metro-style web browser in same package as the desktop version, which has access to functionality unavailable to other apps, such as being able to permanently run in the background, use mult...
The developers of both Chrome and Firefox committed to developing Metro-style versions of their browsers; while Chrome's "Windows 8 mode" uses a full-screen version of the existing desktop interface, Firefox's version (which was first made available on the "Aurora" release channel in September 2013) uses a touch-optimi...
Windows 8 introduces significant changes to the operating system's user interface, many of which are aimed at improving its experience on tablet computers and other touchscreen devices. The new user interface is based on Microsoft's Metro design language, and uses a Start screen similar to that of Windows Phone 7 as th...
A vertical toolbar known as the charms (accessed by swiping from the right edge of a touchscreen, or pointing the cursor at hotspots in the right corners of a screen) provides access to system and app-related functions, such as search, sharing, device management, settings, and a Start button. The traditional desktop en...
Several notable features have been removed in Windows 8, beginning with the traditional Start menu. Support for playing DVD-Video was removed from Windows Media Player due to the cost of licensing the necessary decoders (especially for devices which do not include optical disc drives at all) and the prevalence of onlin...
Backup and Restore, the backup component of Windows, is deprecated. It still ships with Windows 8 and continues to work on preset schedules, but is pushed to the background and can only be accessed through a Control Panel applet called "Windows 7 File Recovery".:76 Shadow Copy, a component of Windows Explorer that once...
Microsoft released minimum hardware requirements for tablet and laplet devices to be "certified" for Windows 8, and defined a convertible form factor as a standalone device that combines the PC, display and rechargeable power source with a mechanically attached keyboard and pointing device in a single chassis. A conver...
Windows 8 is available in three different editions, of which the lowest version, branded simply as Windows 8, and Windows 8 Pro, were sold at retail in most countries, and as pre-loaded software on new computers. Each edition of Windows 8 includes all of the capabilities and features of the edition below it, and add ad...
Windows 8 was distributed as a retail box product on DVD, and through a digital download that could be converted into DVD or USB install media. As part of a launch promotion, Microsoft offered Windows 8 Pro upgrades at a discounted price of US$39.99 online, or $69.99 for retail box from its launch until January 31, 201...
Unlike previous versions of Windows, Windows 8 was distributed at retail in "Upgrade" licenses only, which require an existing version of Windows to install. The "full version software" SKU, which was more expensive but could be installed on computers without an eligible OS or none at all, was discontinued. In lieu of ...
Retail distribution of Windows 8 has since been discontinued in favor of Windows 8.1. Unlike 8, 8.1 is available as "full version software" at both retail and online for download that does not require a previous version of Windows in order to be installed. Pricing for these new copies remain identical. With the retail ...
The three desktop editions of Windows 8 support 32-bit and 64-bit architectures; retail copies of Windows 8 include install DVDs for both architectures, while the online installer automatically installs the version corresponding with the architecture of the system's existing Windows installation. The 32-bit version run...
Windows RT, the only edition of Windows 8 for systems with ARM processors, only supports applications included with the system (such as a special version of Office 2013), supplied through Windows Update, or Windows Store apps, to ensure that the system only runs applications that are optimized for the architecture. Win...
Following the unveiling of Windows 8, Microsoft faced criticism (particularly from free software supporters) for mandating that devices receiving its optional certification for Windows 8 have secure boot enabled by default using a key provided by Microsoft. Concerns were raised that secure boot could prevent or hinder ...
Several notable video game developers criticized Microsoft for making its Windows Store a closed platform subject to its own regulations, as it conflicted with their view of the PC as an open platform. Markus "Notch" Persson (creator of the indie game Minecraft), Gabe Newell (co-founder of Valve Corporation and develop...
Reviews of the various editions of Windows 8 have been mixed. Tom Warren of The Verge said that although Windows 8's emphasis on touch computing was significant and risked alienating desktop users, a "tablet PC with Windows 8 makes an iPad feel immediately out of date" due to the capabilities of the operating system's ...
The interface of Windows 8 has been the subject of mixed reaction. Bright wrote that its system of hot corners and edge swiping "wasn't very obvious" due to the lack of instructions provided by the operating system on the functions accessed through the user interface, even by the video tutorial added on the RTM release...
However, according to research firm NPD, sales of devices running Windows in the United States have declined 21 percent compared to the same time period in 2011. As the holiday shopping season wrapped up, Windows 8 sales continued to lag, even as Apple reported brisk sales. The market research firm IDC reported an over...
Windows 8 surpassed Windows Vista in market share with a 5.1% usage rate according to numbers posted in July 2013 by Net Applications, with usage on a steady upward trajectory. However, intake of Windows 8 still lags behind that of Windows Vista and Windows 7 at the same point in their release cycles. Windows 8's table...
In March 2013, Microsoft also amended its certification requirements to allow tablets to use the 1024×768 resolution as a minimum; this change is expected to allow the production of certified Windows 8 tablets in smaller form factors—a market which is currently dominated by Android-based tablets. Despite the reaction o...
In February 2014, Bloomberg reported that Microsoft would be lowering the price of Windows 8 licenses by 70% for devices that retail under US$250; alongside the announcement that an update to the operating system would allow OEMs to produce devices with as little as 1 GB of RAM and 16 GB of storage, critics felt that t...
In May 2014, the Government of China banned the internal purchase of Windows 8-based products under government contracts requiring "energy-efficient" devices. The Xinhua News Agency claimed that Windows 8 was being banned in protest of Microsoft's support lifecycle policy and the end of support for Windows XP (which, a...
In June 2014, state broadcaster China Central Television (CCTV) broadcast a news story further characterizing Windows 8 as a threat to national security. The story featured an interview with Ni Guangnan, who stated that operating systems could aggregate "sensitive user information" that could be used to "understand the...
An upgrade to Windows 8 known as Windows 8.1 was officially announced by Microsoft on May 14, 2013. Following a presentation devoted to the upgrade at Build 2013, a public beta version of the upgrade was released on June 26, 2013. Windows 8.1 was released to OEM hardware partners on August 27, 2013, and released public...
The upgrade addressed a number of criticisms faced by Windows 8 upon its release, with additional customization options for the Start screen, the restoration of a visible Start button on the desktop, the ability to snap up to four apps on a single display, and the ability to boot to the desktop instead of the Start scr...
At no more than 200 kilometres (120 mi) north to south and 130 kilometres (81 mi) east to west, Swaziland is one of the smallest countries in Africa. Despite its size, however, its climate and topography is diverse, ranging from a cool and mountainous highveld to a hot and dry lowveld. The population is primarily ethni...
Swaziland is a developing country with a small economy. Its GDP per capita of $9,714 means it is classified as a country with a lower-middle income. As a member of the Southern African Customs Union (SACU) and Common Market for Eastern and Southern Africa (COMESA), its main local trading partner is South Africa. Swazil...
Swaziland derives its name from a later king named Mswati II. KaNgwane, named for Ngwane III, is an alternative name for Swaziland the surname of whose royal house remains Nkhosi Dlamini. Nkhosi literally means "king". Mswati II was the greatest of the fighting kings of Swaziland, and he greatly extended the area of th...
In 1903, after British victory in the Anglo-Boer war, Swaziland became a British protectorate. Much of its early administration (for example, postal services) being carried out from South Africa until 1906 when the Transvaal colony was granted self-government. Following this, Swaziland was partitioned into European and...
The constitution for independent Swaziland was promulgated by Britain in November 1963 under the terms of which legislative and executive councils were established. This development was opposed by the Swazi National Council (liqoqo). Despite such opposition, elections took place and the first Legislative Council of Swa...
Following the elections of 1973, the constitution of Swaziland was suspended by King Sobhuza II who thereafter ruled the country by decree until his death in 1982. At this point Sobhuza II had ruled Swaziland for 61 years, making him the longest ruling monarch in history. A regency followed his death, with Queen Regent...
The king appoints the prime minister from the legislature and also appoints a minority of legislators to both chambers of the Libandla (parliament) with help from an advisory council. The king is allowed by the constitution to appoint some members to parliament for special interests. These special interests are citizen...
The Swazi bicameral Parliament or Libandla consists of the Senate (30 seats; 10 members appointed by the House of Assembly and 20 appointed by the monarch; to serve five-year terms) and the House of Assembly (65 seats; 10 members appointed by the monarch and 55 elected by popular vote; to serve five-year terms). The el...
In 2005, the constitution was put into effect. There is still much debate in the country about the constitutional reforms. From the early seventies, there was active resistance to the royal hegemony. Despite complaints from progressive formations, support for the monarchy and the current political system remains strong...
Nominations take place at the chiefdoms. On the day of nomination, the name of the nominee is raised by a show of hand and the nominee is given an opportunity to indicate whether he or she accepts the nomination. If he or she accepts it, he or she must be supported by at least ten members of that chiefdom. The nominati...
As noted above, there are 55 tinkhundla in Swaziland and each elects one representative to the House of Assembly of Swaziland. Each inkhundla has a development committee (bucopho) elected from the various constituency chiefdoms in its area for a five-year term. Bucopho bring to the inkhundla all matters of interest and...
A small, landlocked kingdom, Swaziland is bordered in the North, West and South by the Republic of South Africa and by Mozambique in the East. Swaziland has a land area of 17,364 km2. Swaziland has four separate geographical regions. These run from North to South and are determined by altitude. Swaziland is located at ...
About 75% of the population is employed in subsistence agriculture upon Swazi Nation Land (SNL). In contrast with the commercial farms, Swazi Nation Land suffers from low productivity and investment. This dual nature of the Swazi economy, with high productivity in textile manufacturing and in the industrialised agricul...
Economic growth in Swaziland has lagged behind that of its neighbours. Real GDP growth since 2001 has averaged 2.8%, nearly 2 percentage points lower than growth in other Southern African Customs Union (SACU) member countries. Low agricultural productivity in the SNLs, repeated droughts, the devastating effect of HIV/A...
The considerable spending did not lead to more growth and did not benefit the poor. Much of the increased spending has gone to current expenditures related to wages, transfers, and subsidies. The wage bill today constitutes over 15% of GDP and 55% of total public spending; these are some of the highest levels on the Af...
The Swazi economy is very closely linked to the economy of South Africa, from which it receives over 90% of its imports and to which it sends about 70% of its exports. Swaziland's other key trading partners are the United States and the EU, from whom the country has received trade preferences for apparel exports (under...
Swaziland's currency is pegged to the South African Rand, subsuming Swaziland's monetary policy to South Africa. Customs duties from the Southern African Customs Union, which may equal as much as 70% of government revenue this year, and worker remittances from South Africa substantially supplement domestically earned i...
83% of the total population adheres to Christianity, making it the most common religion in Swaziland. Anglican, Protestant and indigenous African churches, including African Zionist, constitute the majority of the Christians (40%), followed by Roman Catholicism at 20% of the population. On 18 July 2012, Ellinah Wamukoy...
In 2004, the Swaziland government acknowledged for the first time that it suffered an AIDS crisis, with 38.8% of tested pregnant women infected with HIV (see AIDS in Africa). The then Prime Minister Themba Dlamini declared a humanitarian crisis due to the combined effect of drought, land degradation, increased poverty,...
Education in Swaziland begins with pre-school education for infants, primary, secondary and high school education for general education and training (GET), and universities and colleges at tertiary level. Pre-school education is usually for children 5-year or younger after that the students can enroll in a primary scho...
The secondary and high school education system in Swaziland is a five-year programme divided into three years junior secondary and two years senior secondary. There is an external public examination (Junior Certificate) at the end of the junior secondary that learners have to pass to progress to the senior secondary le...
The University of Swaziland, Southern African Nazarene University, Swaziland Christian University are the institutions that offer university education in the country. A campus of Limkokwing University of Creative Technology can be found at Sidvwashini, a suburb of the capital Mbabane. There are some teaching and nursin...
The main centre for technical training in Swaziland is the Swaziland College of Technology which is slated to become a full university. It aims to provide and facilitating high quality training and learning in technology and business studies in collaboration with the Commercial, Industrial and Public Sectors. Other tec...
In addition to these institutions, Swaziland also has the Swaziland Institute of Management and Public Administration (SIMPA) and Institute of Development Management (IDM). SIMPA is a government owned management and development institute and IDM is a regional organisation in Botswana, Lesotho and Swaziland that provide...
The Sangoma is a traditional diviner chosen by the ancestors of that particular family. The training of the Sangoma is called "kwetfwasa". At the end of the training, a graduation ceremony takes place where all the local sangoma come together for feasting and dancing. The diviner is consulted for various reasons, such ...
Swaziland's most well-known cultural event is the annual Umhlanga Reed Dance. In the eight-day ceremony, girls cut reeds and present them to the queen mother and then dance. (There is no formal competition.) It is done in late August or early September. Only childless, unmarried girls can take part. The aims of the cer...
The Reed Dance today is not an ancient ceremony but a development of the old "umchwasho" custom. In "umchwasho", all young girls were placed in a female age-regiment. If any girl became pregnant outside of marriage, her family paid a fine of one cow to the local chief. After a number of years, when the girls had reache...
The English word "translation" derives from the Latin translatio (which itself comes from trans- and from fero, the supine form of which is latum—together meaning "a carrying across" or "a bringing across"). The modern Romance languages use equivalents of the English term "translation" that are derived from that same L...
Despite occasional theoretical diversity, the actual practice of translation has hardly changed since antiquity. Except for some extreme metaphrasers in the early Christian period and the Middle Ages, and adapters in various periods (especially pre-Classical Rome, and the 18th century), translators have generally shown...
In general, translators have sought to preserve the context itself by reproducing the original order of sememes, and hence word order — when necessary, reinterpreting the actual grammatical structure, for example, by shifting from active to passive voice, or vice versa. The grammatical differences between "fixed-word-o...
Generally, the greater the contact and exchange that have existed between two languages, or between those languages and a third one, the greater is the ratio of metaphrase to paraphrase that may be used in translating among them. However, due to shifts in ecological niches of words, a common etymology is sometimes misl...
The translator's role as a bridge for "carrying across" values between cultures has been discussed at least since Terence, the 2nd-century-BCE Roman adapter of Greek comedies. The translator's role is, however, by no means a passive, mechanical one, and so has also been compared to that of an artist. The main ground se...
Though earlier approaches to translation are less commonly used today, they retain importance when dealing with their products, as when historians view ancient or medieval records to piece together events which took place in non-Western or pre-Western environments. Also, though heavily influenced by Western traditions ...
Translation of material into Arabic expanded after the creation of Arabic script in the 5th century, and gained great importance with the rise of Islam and Islamic empires. Arab translation initially focused primarily on politics, rendering Persian, Greek, even Chinese and Indic diplomatic materials into Arabic. It lat...
Arabic translation efforts and techniques are important to Western translation traditions due to centuries of close contacts and exchanges. Especially after the Renaissance, Europeans began more intensive study of Arabic and Persian translations of classical works as well as scientific and philosophical works of Arab a...
The movement to translate English and European texts transformed the Arabic and Ottoman Turkish languages, and new words, simplified syntax, and directness came to be valued over the previous convolutions. Educated Arabs and Turks in the new professions and the modernized civil service expressed skepticism, writes Chri...
After World War I, when Britain and France divided up the Middle East's countries, apart from Turkey, between them, pursuant to the Sykes-Picot agreement—in violation of solemn wartime promises of postwar Arab autonomy—there came an immediate reaction: the Muslim Brotherhood emerged in Egypt, the House of Saud took ove...
Many non-transparent-translation theories draw on concepts from German Romanticism, the most obvious influence being the German theologian and philosopher Friedrich Schleiermacher. In his seminal lecture "On the Different Methods of Translation" (1813) he distinguished between translation methods that move "the writer ...
Comparison of a back-translation with the original text is sometimes used as a check on the accuracy of the original translation, much as the accuracy of a mathematical operation is sometimes checked by reversing the operation. But the results of such reverse-translation operations, while useful as approximate checks, ...
Mark Twain provided humorously telling evidence for the frequent unreliability of back-translation when he issued his own back-translation of a French translation of his short story, "The Celebrated Jumping Frog of Calaveras County". He published his back-translation in a 1903 volume together with his English-language ...
When a historic document survives only in translation, the original having been lost, researchers sometimes undertake back-translation in an effort to reconstruct the original text. An example involves the novel The Saragossa Manuscript by the Polish aristocrat Jan Potocki (1761–1815), who wrote the novel in French and...
Translation has served as a school of writing for many authors. Translators, including monks who spread Buddhist texts in East Asia, and the early modern European translators of the Bible, in the course of their work have shaped the very languages into which they have translated. They have acted as bridges for conveyin...
Interpreters have sometimes played crucial roles in history. A prime example is La Malinche, also known as Malintzin, Malinalli and Doña Marina, an early-16th-century Nahua woman from the Mexican Gulf Coast. As a child she had been sold or given to Maya slave-traders from Xicalango, and thus had become bilingual. Subse...
Web-based human translation is generally favored by companies and individuals that wish to secure more accurate translations. In view of the frequent inaccuracy of machine translations, human translation remains the most reliable, most accurate form of translation available. With the recent emergence of translation cro...
Relying exclusively on unedited machine translation, however, ignores the fact that communication in human language is context-embedded and that it takes a person to comprehend the context of the original text with a reasonable degree of probability. It is certainly true that even purely human-generated translations ar...
In Asia, the spread of Buddhism led to large-scale ongoing translation efforts spanning well over a thousand years. The Tangut Empire was especially efficient in such efforts; exploiting the then newly invented block printing, and with the full support of the government (contemporary sources describe the Emperor and hi...
The Arabs undertook large-scale efforts at translation. Having conquered the Greek world, they made Arabic versions of its philosophical and scientific works. During the Middle Ages, translations of some of these Arabic versions were made into Latin, chiefly at Córdoba in Spain. King Alfonso X el Sabio (Alphonse the Wi...
The first great English translation was the Wycliffe Bible (ca. 1382), which showed the weaknesses of an underdeveloped English prose. Only at the end of the 15th century did the great age of English prose translation begin with Thomas Malory's Le Morte Darthur—an adaptation of Arthurian romances so free that it can, i...