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During the 1800s Christian missionaries from Great Britain and the United States followed traders to the Hawaiian islands. Long-termly, the Anglo-Saxon presence negatively impacted the level of regard Hawaiian royal women held for their own indigenous looks. For centuries prior the arrival of Christians, first nation H...
Racial discrimination continued to be enacted in new laws in the 20th century, for instance the one-drop rule was enacted in Virginia's 1924 Racial Integrity Law and in other southern states, in part influenced by the popularity of eugenics and ideas of racial purity. People buried fading memories that many whites had ...
The phenomenon known as "passing as white" is difficult to explain in other countries or to foreign students. Typical questions are: "Shouldn't Americans say that a person who is passing as white is white, or nearly all white, and has previously been passing as black?" or "To be consistent, shouldn't you say that someo...
Population testing is still being done. Some Native American groups that have been sampled may not have shared the pattern of markers being searched for. Geneticists acknowledge that DNA testing cannot yet distinguish among members of differing cultural Native American nations. There is genetic evidence for three major...
Some multiracial individuals feel marginalized by U.S. society. For example, when applying to schools or for a job, or when taking standardized tests, Americans are sometimes asked to check boxes corresponding to race or ethnicity. Typically, about five race choices are given, with the instruction to "check only one." ...
Prior to the one-drop rule, different states had different laws regarding color. More importantly, social acceptance often played a bigger role in how a person was perceived and how identity was construed than any law. In frontier areas, there were fewer questions about origins. The community looked at how people perfo...
Since the late twentieth century, the number of African and Caribbean ethnic African immigrants have increased in the United States. Together with publicity about the ancestry of President Barack Obama, whose father was from Kenya, some black writers have argued that new terms are needed for recent immigrants. They sug...
In the 1980s, parents of mixed-race children began to organize and lobby for the addition of a more inclusive term of racial designation that would reflect the heritage of their children. When the U.S. government proposed the addition of the category of "bi-racial" or "multiracial" in 1988, the response from the public...
The social identity of the children was strongly determined by the tribe's kinship system. Among the matrilineal tribes of the Southeast, the mixed-race children generally were accepted as and identified as Indian, as they gained their social status from their mother's clans and tribes, and often grew up with their mot...
In the late 19th century, three European-American middle-class female teachers married Indigenous American men they had met at Hampton Institute during the years when it ran its Indian program. In the late nineteenth century, Charles Eastman, a physician of European and Sioux ancestry who trained at Boston University, ...
The writer Sherrel W. Stewart's assertion that "most" African Americans have significant Native American heritage, is not supported by genetic researchers who have done extensive population mapping studies. The TV series on African-American ancestry, hosted by the scholar Henry Louis Gates, Jr., had genetics scholars w...
Interracial relationships have had a long history in North America and the United States, beginning with the intermixing of European explorers and soldiers, who took native women as companions. After European settlement increased, traders and fur trappers often married or had unions with women of native tribes. In the ...
Of numerous relationships between male slaveholders, overseers, or master's sons and women slaves, the most notable is likely that of President Thomas Jefferson with his slave Sally Hemings. As noted in the 2012 collaborative Smithsonian-Monticello exhibit, Slavery at Monticello: The Paradox of Liberty, Jefferson, then...
After the Civil War, racial segregation forced African Americans to share more of a common lot in society than they might have given widely varying ancestry, educational and economic levels. The binary division altered the separate status of the traditionally free people of color in Louisiana, for instance, although th...
Chinese men entered the United States as laborers, primarily on the West Coast and in western territories. Following the Reconstruction era, as blacks set up independent farms, white planters imported Chinese laborers to satisfy their need for labor. In 1882, the Chinese Exclusion Act was passed, and Chinese workers wh...
Multiracial people who wanted to acknowledge their full heritage won a victory of sorts in 1997, when the Office of Management and Budget (OMB) changed the federal regulation of racial categories to permit multiple responses. This resulted in a change to the 2000 United States Census, which allowed participants to sele...
Laws dating from 17th-century colonial America defined children of African slave mothers as taking the status of their mothers, and born into slavery regardless of the race or status of the father, under partus sequitur ventrem. The association of slavery with a "race" led to slavery as a racial caste. But, most famili...
Reacting to media criticism of Michelle Obama during the 2008 presidential election, Charles Kenzie Steele, Jr., CEO of the Southern Christian Leadership Conference said, "Why are they attacking Michelle Obama, and not really attacking, to that degree, her husband? Because he has no slave blood in him." He later claime...
Some early male settlers married Indigenous American women and had informal unions with them. Early contact between Indigenous Americans and Europeans was often charged with tension, but also had moments of friendship, cooperation, and intimacy. Marriages took place in both English and Latin colonies between European m...
Colonial records of French and Spanish slave ships and sales, and plantation records in all the former colonies, often have much more information about slaves, from which researchers are reconstructing slave family histories. Genealogists have begun to find plantation records, court records, land deeds and other source...
European colonists created treaties with Indigenous American tribes requesting the return of any runaway slaves. For example, in 1726, the British governor of New York exacted a promise from the Iroquois to return all runaway slaves who had joined them. This same promise was extracted from the Huron Nation in 1764, and...
Interracial relationships, common-law marriages, and marriages occurred since the earliest colonial years, especially before slavery hardened as a racial caste associated with people of African descent in the British colonies. Virginia and other English colonies passed laws in the 17th century that gave children the so...
Many Latin American migrants have been mestizo, Amerindian, or other mixed race. Multiracial Latinos have limited media appearance; critics have accused the U.S. Hispanic media of overlooking the brown-skinned indigenous and multiracial Hispanic and black Hispanic populations by over-representation of blond and blue/gr...
In Virginia prior to 1920, for example, a person was legally white if having seven-eights or more white ancestry. The one-drop rule originated in some Southern United States in the late 19th century, likely in response to whites' attempt to maintain white supremacy and limit black political power following the Democrat...
Stanley Crouch wrote in a New York Daily News piece "Obama's mother is of white U.S. stock. His father is a black Kenyan," in a column entitled "What Obama Isn't: Black Like Me." During the 2008 campaign, the African-American columnist David Ehrenstein of the LA Times accused white liberals of flocking to Obama because...
The 2000 U.S. Census in the write-in response category had a code listing which standardizes the placement of various write-in responses for automatic placement within the framework of the U.S. Census's enumerated races. Whereas most responses can be distinguished as falling into one of the five enumerated races, there...
Interracial relations between Indigenous Americans and African Americans is a part of American history that has been neglected. The earliest record of African and Indigenous American relations in the Americas occurred in April 1502, when the first Africans kidnapped were brought to Hispaniola to serve as slaves. Some e...
Some biographical accounts include the autobiography Life on the Color Line: The True Story of a White Boy Who Discovered He Was Black by Gregory Howard Williams; One Drop: My Father's Hidden Life—A Story of Race and Family Secrets written by Bliss Broyard about her father Anatole Broyard; the documentary Colored White...
By the 1980s, parents of mixed-race children (and adults of mixed-race ancestry) began to organize and lobby for the ability to show more than one ethnic category on Census and other legal forms. They refused to be put into just one category. When the U.S. government proposed the addition of the category of "bi-racial"...
In the early 19th century, the Indigenous American woman Sacagawea, who would help translate for and guide the Lewis and Clark Expedition in the West, married the French trapper Toussaint Charbonneau. Most marriages between Europeans and Indigenous Americans were between European men and Indigenous American women. Depe...
For African Americans, the one-drop rule was a significant factor in ethnic solidarity. African Americans generally shared a common cause in society regardless of their multiracial admixture, or social/economic stratification. Additionally, African Americans found it, near, impossible to learn about their Indigenous Am...
The figure of the "tragic octoroon" was a stock character of abolitionist literature: a mixed-race woman raised as if a white woman in her white father's household, until his bankruptcy or death has her reduced to a menial position She may even be unaware of her status before being reduced to victimization. The first c...
By the 1890s the profound effect of adrenal extracts on many different tissue types had been discovered, setting off a search both for the mechanism of chemical signalling and efforts to exploit these observations for the development of new drugs. The blood pressure raising and vasoconstrictive effects of adrenal extra...
While highly effective, the requirement for injection limited the use of norepinephrine[clarification needed] and orally active derivatives were sought. A structurally similar compound, ephedrine, was identified by Japanese chemists in the Ma Huang plant and marketed by Eli Lilly as an oral treatment for asthma. Follow...
A series of experiments performed from the late 1800s to the early 1900s revealed that diabetes is caused by the absence of a substance normally produced by the pancreas. In 1869, Oskar Minkowski and Joseph von Mering found that diabetes could be induced in dogs by surgical removal of the pancreas. In 1921, Canadian pr...
In 1903 Hermann Emil Fischer and Joseph von Mering disclosed their discovery that diethylbarbituric acid, formed from the reaction of diethylmalonic acid, phosphorus oxychloride and urea, induces sleep in dogs. The discovery was patented and licensed to Bayer pharmaceuticals, which marketed the compound under the trade...
In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan. Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes...
The modern pharmaceutical industry traces its roots to two sources. The first of these were local apothecaries that expanded from their traditional role distributing botanical drugs such as morphine and quinine to wholesale manufacture in the mid 1800s. Rational drug discovery from plants started particularly with the ...
Ehrlich’s approach of systematically varying the chemical structure of synthetic compounds and measuring the effects of these changes on biological activity was pursued broadly by industrial scientists, including Bayer scientists Josef Klarer, Fritz Mietzsch, and Gerhard Domagk. This work, also based in the testing of ...
Early progress toward the development of vaccines occurred throughout this period, primarily in the form of academic and government-funded basic research directed toward the identification of the pathogens responsible for common communicable diseases. In 1885 Louis Pasteur and Pierre Paul Émile Roux created the first r...
In 1937 over 100 people died after ingesting "Elixir Sulfanilamide" manufactured by S.E. Massengill Company of Tennessee. The product was formulated in diethylene glycol, a highly toxic solvent that is now widely used as antifreeze. Under the laws extant at that time, prosecution of the manufacturer was possible only u...
The aftermath of World War II saw an explosion in the discovery of new classes of antibacterial drugs including the cephalosporins (developed by Eli Lilly based on the seminal work of Giuseppe Brotzu and Edward Abraham), streptomycin (discovered during a Merck-funded research program in Selman Waksman's laboratory), th...
During the years 1940-1955, the rate of decline in the U.S. death rate accelerated from 2% per year to 8% per year, then returned to the historical rate of 2% per year. The dramatic decline in the immediate post-war years has been attributed to the rapid development of new treatments and vaccines for infectious disease...
On 2 July 2012, GlaxoSmithKline pleaded guilty to criminal charges and agreed to a $3 billion settlement of the largest health-care fraud case in the U.S. and the largest payment by a drug company. The settlement is related to the company's illegal promotion of prescription drugs, its failure to report safety data, bri...
In the US, starting in 2013, under the Physician Financial Transparency Reports (part of the Sunshine Act), the Centers for Medicare & Medicaid Services has to collect information from applicable manufacturers and group purchasing organizations in order to report information about their financial relationships with phy...
A Federal Trade Commission report issued in 1958 attempted to quantify the effect of antibiotic development on American public health. The report found that over the period 1946-1955, there was a 42% drop in the incidence of diseases for which antibiotics were effective and only a 20% drop in those for which antibiotic...
In March 2001, 40 multi-national pharmaceutical companies brought litigation against South Africa for its Medicines Act, which allowed the generic production of antiretroviral drugs (ARVs) for treating HIV, despite the fact that these drugs were on-patent. HIV was and is an epidemic in South Africa, and ARVs at the tim...
Prior to the 20th century drugs were generally produced by small scale manufacturers with little regulatory control over manufacturing or claims of safety and efficacy. To the extent that such laws did exist, enforcement was lax. In the United States, increased regulation of vaccines and other biological drugs was spur...
Patents have been criticized in the developing world, as they are thought to reduce access to existing medicines. Reconciling patents and universal access to medicine would require an efficient international policy of price discrimination. Moreover, under the TRIPS agreement of the World Trade Organization, countries m...
Pharmaceutical fraud involves deceptions which bring financial gain to a pharmaceutical company. It affects individuals and public and private insurers. There are several different schemes used to defraud the health care system which are particular to the pharmaceutical industry. These include: Good Manufacturing Pract...
A 2009 Cochrane review concluded that thiazide antihypertensive drugs reduce the risk of death (RR 0.89), stroke (RR 0.63), coronary heart disease (RR 0.84), and cardiovascular events (RR 0.70) in people with high blood pressure. In the ensuring years other classes of antihypertensive drug were developed and found wide...
Others have argued that excessive regulation suppresses therapeutic innovation, and that the current cost of regulator-required clinical trials prevents the full exploitation of new genetic and biological knowledge for the treatment of human disease. A 2012 report by the President's Council of Advisors on Science and T...
In 1952 researchers at Ciba discovered the first orally available vasodilator, hydralazine. A major shortcoming of hydralazine monotherapy was that it lost its effectiveness over time (tachyphylaxis). In the mid-1950s Karl H. Beyer, James M. Sprague, John E. Baer, and Frederick C. Novello of Merck and Co. discovered an...
In the U.S., a push for revisions of the FD&C Act emerged from Congressional hearings led by Senator Estes Kefauver of Tennessee in 1959. The hearings covered a wide range of policy issues, including advertising abuses, questionable efficacy of drugs, and the need for greater regulation of the industry. While momentum ...
Other notable new vaccines of the period include those for measles (1962, John Franklin Enders of Children's Medical Center Boston, later refined by Maurice Hilleman at Merck), Rubella (1969, Hilleman, Merck) and mumps (1967, Hilleman, Merck) The United States incidences of rubella, congenital rubella syndrome, measles...
The thalidomide tragedy resurrected Kefauver's bill to enhance drug regulation that had stalled in Congress, and the Kefauver-Harris Amendment became law on 10 October 1962. Manufacturers henceforth had to prove to FDA that their drugs were effective as well as safe before they could go on the US market. The FDA receiv...
The firm continued to pressure Kelsey and the agency to approve the application—until November 1961, when the drug was pulled off the German market because of its association with grave congenital abnormalities. Several thousand newborns in Europe and elsewhere suffered the teratogenic effects of thalidomide. Though th...
Prior to the second world war, birth control was prohibited in many countries, and in the United States even the discussion of contraceptive methods sometimes led to prosecution under Comstock laws. The history of the development of oral contraceptives is thus closely tied to the birth control movement and the efforts ...
In April 1994, the results of a Merck-sponsored study, the Scandinavian Simvastatin Survival Study, were announced. Researchers tested simvastatin, later sold by Merck as Zocor, on 4,444 patients with high cholesterol and heart disease. After five years, the study concluded the patients saw a 35% reduction in their cho...
Drug discovery is the process by which potential drugs are discovered or designed. In the past most drugs have been discovered either by isolating the active ingredient from traditional remedies or by serendipitous discovery. Modern biotechnology often focuses on understanding the metabolic pathways related to a diseas...
Drug discovery and development is very expensive; of all compounds investigated for use in humans only a small fraction are eventually approved in most nations by government appointed medical institutions or boards, who have to approve new drugs before they can be marketed in those countries. In 2010 18 NMEs (New Molec...
Some of these estimates also take into account the opportunity cost of investing capital many years before revenues are realized (see Time-value of money). Because of the very long time needed for discovery, development, and approval of pharmaceuticals, these costs can accumulate to nearly half the total expense. A dir...
In 1971, Akira Endo, a Japanese biochemist working for the pharmaceutical company Sankyo, identified mevastatin (ML-236B), a molecule produced by the fungus Penicillium citrinum, as an inhibitor of HMG-CoA reductase, a critical enzyme used by the body to produce cholesterol. Animal trials showed very good inhibitory ef...
Every major company selling the antipsychotics — Bristol-Myers Squibb, Eli Lilly, Pfizer, AstraZeneca and Johnson & Johnson — has either settled recent government cases, under the False Claims Act, for hundreds of millions of dollars or is currently under investigation for possible health care fraud. Following charges ...
In contrast to this viewpoint, an article and associated editorial in the New England Journal of Medicine in May 2015 emphasized the importance of pharmaceutical industry-physician interactions for the development of novel treatments, and argued that moral outrage over industry malfeasance had unjustifiably led many to...
An investigation by ProPublica found that at least 21 doctors have been paid more than $500,000 for speeches and consulting by drugs manufacturers since 2009, with half of the top earners working in psychiatry, and about $2 billion in total paid to doctors for such services. AstraZeneca, Johnson & Johnson and Eli Lilly...
Often, large multinational corporations exhibit vertical integration, participating in a broad range of drug discovery and development, manufacturing and quality control, marketing, sales, and distribution. Smaller organizations, on the other hand, often focus on a specific aspect such as discovering drug candidates or...
In the UK, the Medicines and Healthcare Products Regulatory Agency approves drugs for use, though the evaluation is done by the European Medicines Agency, an agency of the European Union based in London. Normally an approval in the UK and other European countries comes later than one in the USA. Then it is the National...
There are special rules for certain rare diseases ("orphan diseases") in several major drug regulatory territories. For example, diseases involving fewer than 200,000 patients in the United States, or larger populations in certain circumstances are subject to the Orphan Drug Act. Because medical research and developmen...
Ben Goldacre has argued that regulators – such as the Medicines and Healthcare products Regulatory Agency (MHRA) in the UK, or the Food and Drug Administration (FDA) in the United States – advance the interests of the drug companies rather than the interests of the public due to revolving door exchange of employees bet...
In many non-US western countries a 'fourth hurdle' of cost effectiveness analysis has developed before new technologies can be provided. This focuses on the efficiency (in terms of the cost per QALY) of the technologies in question rather than their efficacy. In England and Wales NICE decides whether and in what circum...
The top ten best-selling drugs of 2013 totaled $75.6 billion in sales, with the anti-inflammatory drug Humira being the best-selling drug worldwide at $10.7 billion in sales. The second and third best selling were Enbrel and Remicade, respectively. The top three best-selling drugs in the United States in 2013 were Abil...
Depending on a number of considerations, a company may apply for and be granted a patent for the drug, or the process of producing the drug, granting exclusivity rights typically for about 20 years. However, only after rigorous study and testing, which takes 10 to 15 years on average, will governmental authorities gran...
In the United States, new pharmaceutical products must be approved by the Food and Drug Administration (FDA) as being both safe and effective. This process generally involves submission of an Investigational New Drug filing with sufficient pre-clinical data to support proceeding with human trials. Following IND approva...
Advertising is common in healthcare journals as well as through more mainstream media routes. In some countries, notably the US, they are allowed to advertise directly to the general public. Pharmaceutical companies generally employ sales people (often called 'drug reps' or, an older term, 'detail men') to market direc...
There has been increasing controversy surrounding pharmaceutical marketing and influence. There have been accusations and findings of influence on doctors and other health professionals through drug reps, including the constant provision of marketing 'gifts' and biased information to health professionals; highly preval...
The rivalries between the Arab tribes had caused unrest in the provinces outside Syria, most notably in the Second Muslim Civil War of 680–692 CE and the Berber Revolt of 740–743 CE. During the Second Civil War, leadership of the Umayyad clan shifted from the Sufyanid branch of the family to the Marwanid branch. As the...
Ali was assassinated in 661 by a Kharijite partisan. Six months later in the same year, in the interest of peace, Hasan ibn Ali, highly regarded for his wisdom and as a peacemaker, and the Second Imam for the Shias, and the grandson of Muhammad, made a peace treaty with Muawiyah I. In the Hasan-Muawiya treaty, Hasan ib...
At the time, the Umayyad taxation and administrative practice were perceived as unjust by some Muslims. The Christian and Jewish population had still autonomy; their judicial matters were dealt with in accordance with their own laws and by their own religious heads or their appointees, although they did pay a poll tax ...
The Umayyad Caliphate (Arabic: الخلافة الأموية‎, trans. Al-Khilāfat al-ʾumawiyya) was the second of the four major Islamic caliphates established after the death of Muhammad. This caliphate was centered on the Umayyad dynasty (Arabic: الأمويون‎, al-ʾUmawiyyūn, or بنو أمية, Banū ʾUmayya, "Sons of Umayya"), hailing from ...
Most historians[who?] consider Caliph Muawiyah (661–80) to have been the second ruler of the Umayyad dynasty, even though he was the first to assert the Umayyads' right to rule on a dynastic principle. It was really the caliphate of Uthman Ibn Affan (644–656), a member of Umayyad clan himself, that witnessed the reviva...
Following the death of Husayn, Ibn al-Zubayr, although remaining in Mecca, was associated with two opposition movements, one centered in Medina and the other around Kharijites in Basra and Arabia. Because Medina had been home to Muhammad and his family, including Husayn, word of his death and the imprisonment of his fa...
According to tradition, the Umayyad family (also known as the Banu Abd-Shams) and Muhammad both descended from a common ancestor, Abd Manaf ibn Qusai, and they originally came from the city of Mecca. Muhammad descended from Abd Manāf via his son Hashim, while the Umayyads descended from Abd Manaf via a different son, A...
Following this battle, Ali fought a battle against Muawiyah, known as the Battle of Siffin. The battle was stopped before either side had achieved victory, and the two parties agreed to arbitrate their dispute. After the battle Amr ibn al-As was appointed by Muawiyah as an arbitrator, and Ali appointed Abu Musa Ashaari...
The Quran and Muhammad talked about racial equality and justice as in The Farewell Sermon. Tribal and nationalistic differences were discouraged. But after Muhammad's passing, the old tribal differences between the Arabs started to resurface. Following the Roman–Persian Wars and the Byzantine–Sassanid Wars, deep rooted...
While the Umayyads and the Hashimites may have had bitterness between the two clans before Muhammad, the rivalry turned into a severe case of tribal animosity after the Battle of Badr. The battle saw three top leaders of the Umayyad clan (Utba ibn Rabi'ah, Walid ibn Utbah and Shaybah) killed by Hashimites (Ali, Hamza i...
Umar is honored for his attempt to resolve the fiscal problems attendant upon conversion to Islam. During the Umayyad period, the majority of people living within the caliphate were not Muslim, but Christian, Jewish, Zoroastrian, or members of other small groups. These religious communities were not forced to convert t...
After the assassination of Uthman in 656, Ali, a member of the Quraysh tribe and the cousin and son-in-law of Muhammad, was elected as the caliph. He soon met with resistance from several factions, owing to his relative political inexperience. Ali moved his capital from Medina to Kufa. The resulting conflict, which las...
Early Muslim armies stayed in encampments away from cities because Umar feared that they might get attracted to wealth and luxury. In the process, they might turn away from the worship of God and start accumulating wealth and establishing dynasties. When Uthman ibn al-Affan became very old, Marwan I, a relative of Muaw...
In 680 Ibn al-Zubayr fled Medina for Mecca. Hearing about Husayn's opposition to Yazid I, the people of Kufa sent to Husayn asking him to take over with their support. Al-Husayn sent his cousin Muslim bin Agail to verify if they would rally behind him. When the news reached Yazid I, he sent Ubayd-Allah bin Ziyad, ruler...
In the year 712, Muhammad bin Qasim, an Umayyad general, sailed from the Persian Gulf into Sindh in Pakistan and conquered both the Sindh and the Punjab regions along the Indus river. The conquest of Sindh and Punjab, in modern-day Pakistan, although costly, were major gains for the Umayyad Caliphate. However, further ...
The second major event of the early reign of Abd al-Malik was the construction of the Dome of the Rock in Jerusalem. Although the chronology remains somewhat uncertain, the building seems to have been completed in 692, which means that it was under construction during the conflict with Ibn al-Zubayr. This had led some ...
Muawiyah also encouraged peaceful coexistence with the Christian communities of Syria, granting his reign with "peace and prosperity for Christians and Arabs alike", and one of his closest advisers was Sarjun, the father of John of Damascus. At the same time, he waged unceasing war against the Byzantine Roman Empire. D...
Yazid died while the siege was still in progress, and the Umayyad army returned to Damascus, leaving Ibn al-Zubayr in control of Mecca. Yazid's son Muawiya II (683–84) initially succeeded him but seems to have never been recognized as caliph outside of Syria. Two factions developed within Syria: the Confederation of Qa...
Marwan was succeeded by his son, Abd al-Malik (685–705), who reconsolidated Umayyad control of the caliphate. The early reign of Abd al-Malik was marked by the revolt of Al-Mukhtar, which was based in Kufa. Al-Mukhtar hoped to elevate Muhammad ibn al-Hanafiyyah, another son of Ali, to the caliphate, although Ibn al-Han...
Geographically, the empire was divided into several provinces, the borders of which changed numerous times during the Umayyad reign. Each province had a governor appointed by the khalifah. The governor was in charge of the religious officials, army leaders, police, and civil administrators in his province. Local expens...
Hisham suffered still worse defeats in the east, where his armies attempted to subdue both Tokharistan, with its center at Balkh, and Transoxiana, with its center at Samarkand. Both areas had already been partially conquered, but remained difficult to govern. Once again, a particular difficulty concerned the question o...
The Hashimiyya movement (a sub-sect of the Kaysanites Shia), led by the Abbasid family, overthrew the Umayyad caliphate. The Abbasids were members of the Hashim clan, rivals of the Umayyads, but the word "Hashimiyya" seems to refer specifically to Abu Hashim, a grandson of Ali and son of Muhammad ibn al-Hanafiyya. Acco...
From the caliphate's north-western African bases, a series of raids on coastal areas of the Visigothic Kingdom paved the way to the permanent occupation of most of Iberia by the Umayyads (starting in 711), and on into south-eastern Gaul (last stronghold at Narbonne in 759). Hisham's reign witnessed the end of expansion...
The final son of Abd al-Malik to become caliph was Hisham (724–43), whose long and eventful reign was above all marked by the curtailment of military expansion. Hisham established his court at Resafa in northern Syria, which was closer to the Byzantine border than Damascus, and resumed hostilities against the Byzantine...

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